Stem definition | Drug id | CAS RN |
---|---|---|
psychoactive | 1816 | 85650-52-8 |
Dose | Unit | Route |
---|---|---|
30 | mg | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.50 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 2 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 2.83 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 50 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 4.20 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 8 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.15 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 15 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
June 14, 1996 | FDA | ORGANON USA INC |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Intentional overdose | 786.99 | 10.00 | 795 | 104990 | 67322 | 56118960 |
Drug abuse | 584.15 | 10.00 | 677 | 105108 | 66933 | 56119349 |
Serotonin syndrome | 582.47 | 10.00 | 446 | 105339 | 26044 | 56160238 |
Suicide attempt | 573.00 | 10.00 | 622 | 105163 | 57214 | 56129068 |
Intentional self-injury | 554.37 | 10.00 | 423 | 105362 | 24569 | 56161713 |
Toxicity to various agents | 535.91 | 10.00 | 1253 | 104532 | 223311 | 55962971 |
Rheumatoid arthritis | 476.44 | 10.00 | 75 | 105710 | 382529 | 55803753 |
Sopor | 454.97 | 10.00 | 350 | 105435 | 20572 | 56165710 |
Completed suicide | 412.89 | 10.00 | 829 | 104956 | 133004 | 56053278 |
Suicidal ideation | 390.09 | 10.00 | 511 | 105274 | 57231 | 56129051 |
Drug interaction | 377.92 | 10.00 | 1053 | 104732 | 208702 | 55977580 |
Electrocardiogram QT prolonged | 371.71 | 10.00 | 485 | 105300 | 54103 | 56132179 |
Hyponatraemia | 329.69 | 10.00 | 645 | 105140 | 101494 | 56084788 |
Overdose | 312.52 | 10.00 | 644 | 105141 | 105186 | 56081096 |
Somnolence | 299.66 | 10.00 | 826 | 104959 | 162587 | 56023695 |
Agitation | 279.38 | 10.00 | 429 | 105356 | 55607 | 56130675 |
Systemic lupus erythematosus | 268.08 | 10.00 | 18 | 105767 | 180060 | 56006222 |
Joint swelling | 259.54 | 10.00 | 110 | 105675 | 289690 | 55896592 |
Pemphigus | 258.96 | 10.00 | 8 | 105777 | 157204 | 56029078 |
Arthropathy | 240.61 | 10.00 | 43 | 105742 | 200232 | 55986050 |
Infusion related reaction | 228.10 | 10.00 | 56 | 105729 | 208875 | 55977407 |
Glossodynia | 219.03 | 10.00 | 18 | 105767 | 152440 | 56033842 |
Treatment failure | 210.34 | 10.00 | 34 | 105751 | 170358 | 56015924 |
Tremor | 207.03 | 10.00 | 597 | 105188 | 120492 | 56065790 |
Depression | 206.40 | 10.00 | 775 | 105010 | 179342 | 56006940 |
Restlessness | 205.94 | 10.00 | 252 | 105533 | 26334 | 56159948 |
Depressed level of consciousness | 201.24 | 10.00 | 372 | 105413 | 56061 | 56130221 |
Rash | 199.57 | 10.00 | 391 | 105394 | 492656 | 55693626 |
Drug ineffective | 197.87 | 10.00 | 974 | 104811 | 918015 | 55268267 |
Alopecia | 196.71 | 10.00 | 158 | 105627 | 293300 | 55892982 |
Contraindicated product administered | 193.69 | 10.00 | 55 | 105730 | 186231 | 56000051 |
Disorientation | 193.36 | 10.00 | 288 | 105497 | 36325 | 56149957 |
Neuroleptic malignant syndrome | 190.35 | 10.00 | 164 | 105621 | 11314 | 56174968 |
Swelling | 187.44 | 10.00 | 109 | 105676 | 239662 | 55946620 |
Synovitis | 186.55 | 10.00 | 38 | 105747 | 161267 | 56025015 |
Tachycardia | 185.81 | 10.00 | 527 | 105258 | 105349 | 56080933 |
Muscle rigidity | 184.17 | 10.00 | 156 | 105629 | 10515 | 56175767 |
Inappropriate antidiuretic hormone secretion | 181.82 | 10.00 | 173 | 105612 | 13583 | 56172699 |
Coma | 172.40 | 10.00 | 360 | 105425 | 59295 | 56126987 |
Fall | 171.59 | 10.00 | 1204 | 104581 | 356306 | 55829976 |
Sinusitis | 170.45 | 10.00 | 79 | 105706 | 197502 | 55988780 |
Abdominal discomfort | 170.41 | 10.00 | 162 | 105623 | 277112 | 55909170 |
Confusional state | 170.14 | 10.00 | 808 | 104977 | 207347 | 55978935 |
Anxiety | 166.80 | 10.00 | 762 | 105023 | 192410 | 55993872 |
Disturbance in attention | 163.35 | 10.00 | 250 | 105535 | 32290 | 56153992 |
Dissociation | 160.31 | 10.00 | 84 | 105701 | 2501 | 56183781 |
Therapeutic product effect decreased | 153.67 | 10.00 | 63 | 105722 | 169389 | 56016893 |
Akathisia | 152.43 | 10.00 | 128 | 105657 | 8524 | 56177758 |
Pain | 151.00 | 10.00 | 688 | 105097 | 662496 | 55523786 |
Depersonalisation/derealisation disorder | 148.47 | 10.00 | 64 | 105721 | 1215 | 56185067 |
Drug intolerance | 146.64 | 10.00 | 169 | 105616 | 264649 | 55921633 |
Pericarditis | 138.34 | 10.00 | 20 | 105765 | 108903 | 56077379 |
Dyskinesia | 138.24 | 10.00 | 218 | 105567 | 28890 | 56157392 |
Nasopharyngitis | 138.17 | 10.00 | 127 | 105658 | 220832 | 55965450 |
Hypersensitivity | 137.30 | 10.00 | 168 | 105617 | 256240 | 55930042 |
Mydriasis | 132.75 | 10.00 | 132 | 105653 | 10939 | 56175343 |
Restless legs syndrome | 130.20 | 10.00 | 160 | 105625 | 16787 | 56169495 |
Depressed mood | 127.48 | 10.00 | 238 | 105547 | 36121 | 56150161 |
Gastric pH decreased | 126.39 | 10.00 | 48 | 105737 | 646 | 56185636 |
Nightmare | 123.09 | 10.00 | 155 | 105630 | 16671 | 56169611 |
Arthralgia | 122.79 | 10.00 | 506 | 105279 | 501163 | 55685119 |
Derealisation | 118.65 | 10.00 | 52 | 105733 | 1029 | 56185253 |
Peripheral swelling | 117.20 | 10.00 | 162 | 105623 | 234564 | 55951718 |
Helicobacter infection | 116.19 | 10.00 | 5 | 105780 | 73263 | 56113019 |
Discomfort | 115.68 | 10.00 | 61 | 105724 | 141700 | 56044582 |
Duodenal ulcer perforation | 114.23 | 10.00 | 3 | 105782 | 68339 | 56117943 |
Urinary retention | 112.78 | 10.00 | 195 | 105590 | 27879 | 56158403 |
Drug withdrawal syndrome | 111.01 | 10.00 | 185 | 105600 | 25672 | 56160610 |
Drug hypersensitivity | 110.41 | 10.00 | 219 | 105566 | 274986 | 55911296 |
Aggression | 110.34 | 10.00 | 169 | 105616 | 21837 | 56164445 |
Hallucination | 110.00 | 10.00 | 268 | 105517 | 48881 | 56137401 |
Feeling of despair | 108.56 | 10.00 | 61 | 105724 | 2092 | 56184190 |
Product use issue | 105.90 | 10.00 | 116 | 105669 | 185925 | 56000357 |
Mania | 105.49 | 10.00 | 119 | 105666 | 11401 | 56174881 |
Dysarthria | 105.39 | 10.00 | 231 | 105554 | 39319 | 56146963 |
Hyperhidrosis | 103.60 | 10.00 | 400 | 105385 | 93688 | 56092594 |
Cogwheel rigidity | 102.37 | 10.00 | 56 | 105729 | 1821 | 56184461 |
Delirium | 101.80 | 10.00 | 238 | 105547 | 42279 | 56144003 |
Psoriatic arthropathy | 95.34 | 10.00 | 13 | 105772 | 73995 | 56112287 |
Seizure | 91.61 | 10.00 | 471 | 105314 | 124648 | 56061634 |
Impaired healing | 91.38 | 10.00 | 25 | 105760 | 86816 | 56099466 |
Folliculitis | 89.75 | 10.00 | 3 | 105782 | 54976 | 56131306 |
Wound | 88.84 | 10.00 | 78 | 105707 | 138726 | 56047556 |
Dystonia | 88.60 | 10.00 | 113 | 105672 | 12308 | 56173974 |
Withdrawal syndrome | 87.28 | 10.00 | 138 | 105647 | 18324 | 56167958 |
Hallucination, visual | 83.17 | 10.00 | 131 | 105654 | 17337 | 56168945 |
Poisoning | 82.75 | 10.00 | 111 | 105674 | 12702 | 56173580 |
Psychotic disorder | 82.31 | 10.00 | 154 | 105631 | 23404 | 56162878 |
Injection site pain | 79.66 | 10.00 | 62 | 105723 | 117056 | 56069226 |
Rheumatoid factor negative | 79.56 | 10.00 | 33 | 105752 | 567 | 56185715 |
Urticaria | 79.26 | 10.00 | 93 | 105692 | 144583 | 56041699 |
Tardive dyskinesia | 77.04 | 10.00 | 85 | 105700 | 7946 | 56178336 |
Parkinsonism | 76.37 | 10.00 | 92 | 105693 | 9454 | 56176828 |
H1N1 influenza | 75.90 | 10.00 | 44 | 105741 | 1603 | 56184679 |
General physical health deterioration | 73.48 | 10.00 | 559 | 105226 | 169451 | 56016831 |
Loss of consciousness | 73.44 | 10.00 | 402 | 105383 | 108947 | 56077335 |
Drooling | 72.76 | 10.00 | 57 | 105728 | 3437 | 56182845 |
Hepatic enzyme increased | 72.50 | 10.00 | 132 | 105653 | 171252 | 56015030 |
Muscle injury | 70.60 | 10.00 | 8 | 105777 | 52492 | 56133790 |
Lower respiratory tract infection | 69.32 | 10.00 | 68 | 105717 | 114726 | 56071556 |
Blister | 68.69 | 10.00 | 62 | 105723 | 108825 | 56077457 |
Myoclonus | 68.25 | 10.00 | 111 | 105674 | 15092 | 56171190 |
Irritable bowel syndrome | 67.85 | 10.00 | 22 | 105763 | 68436 | 56117846 |
Infection | 67.48 | 10.00 | 175 | 105610 | 200031 | 55986251 |
Maternal exposure during pregnancy | 64.40 | 10.00 | 165 | 105620 | 189388 | 55996894 |
Hallucination, auditory | 64.21 | 10.00 | 93 | 105692 | 11431 | 56174851 |
Speech disorder | 64.11 | 10.00 | 185 | 105600 | 37308 | 56148974 |
Pleurothotonus | 62.76 | 10.00 | 36 | 105749 | 1285 | 56184997 |
Mood swings | 61.68 | 10.00 | 112 | 105673 | 16635 | 56169647 |
Intestinal pseudo-obstruction | 61.42 | 10.00 | 30 | 105755 | 767 | 56185515 |
Depressive symptom | 59.53 | 10.00 | 51 | 105734 | 3490 | 56182792 |
Incontinence | 58.89 | 10.00 | 86 | 105699 | 10649 | 56175633 |
Major depression | 58.89 | 10.00 | 72 | 105713 | 7512 | 56178770 |
Knee arthroplasty | 58.88 | 10.00 | 7 | 105778 | 44252 | 56142030 |
Parosmia | 58.02 | 10.00 | 57 | 105728 | 4654 | 56181628 |
Arthritis | 57.06 | 10.00 | 62 | 105723 | 99790 | 56086492 |
Hypertonia | 57.01 | 10.00 | 53 | 105732 | 4039 | 56182243 |
Asphyxia | 56.79 | 10.00 | 62 | 105723 | 5727 | 56180555 |
C-reactive protein abnormal | 56.78 | 10.00 | 3 | 105782 | 36806 | 56149476 |
Sedation | 56.74 | 10.00 | 169 | 105616 | 34685 | 56151597 |
Accidental overdose | 56.20 | 10.00 | 121 | 105664 | 20340 | 56165942 |
Intentional product use issue | 55.81 | 10.00 | 63 | 105722 | 99670 | 56086612 |
Progressive multifocal leukoencephalopathy | 55.69 | 10.00 | 89 | 105696 | 11924 | 56174358 |
Pallor | 55.43 | 10.00 | 133 | 105652 | 24016 | 56162266 |
Injection site erythema | 55.24 | 10.00 | 39 | 105746 | 77409 | 56108873 |
Schizophrenia | 54.56 | 10.00 | 82 | 105703 | 10417 | 56175865 |
Feeling jittery | 54.14 | 10.00 | 88 | 105697 | 11958 | 56174324 |
Gastrointestinal disorder | 53.99 | 10.00 | 80 | 105705 | 112622 | 56073660 |
Hyperkinesia | 53.15 | 10.00 | 35 | 105750 | 1604 | 56184678 |
Pruritus | 52.88 | 10.00 | 363 | 105422 | 316260 | 55870022 |
Altered state of consciousness | 51.99 | 10.00 | 126 | 105659 | 22895 | 56163387 |
Drug dependence | 51.61 | 10.00 | 124 | 105661 | 22409 | 56163873 |
Fatigue | 51.51 | 10.00 | 1111 | 104674 | 787441 | 55398841 |
Gestational diabetes | 50.76 | 10.00 | 69 | 105716 | 7995 | 56178287 |
Neonatal seizure | 50.59 | 10.00 | 22 | 105763 | 427 | 56185855 |
Cardiac arrest | 50.53 | 10.00 | 306 | 105479 | 86008 | 56100274 |
Psoriasis | 50.30 | 10.00 | 60 | 105725 | 92632 | 56093650 |
Injection site pruritus | 50.29 | 10.00 | 9 | 105776 | 41922 | 56144360 |
Extrapyramidal disorder | 49.84 | 10.00 | 86 | 105699 | 12270 | 56174012 |
Abnormal dreams | 49.63 | 10.00 | 75 | 105710 | 9574 | 56176708 |
Headache | 48.92 | 10.00 | 748 | 105037 | 558296 | 55627986 |
Impulsive behaviour | 48.43 | 10.00 | 32 | 105753 | 1475 | 56184807 |
Feeling of body temperature change | 48.28 | 10.00 | 51 | 105734 | 4538 | 56181744 |
Psychomotor retardation | 48.20 | 10.00 | 46 | 105739 | 3623 | 56182659 |
Stomatitis | 47.62 | 10.00 | 97 | 105688 | 120713 | 56065569 |
Polydipsia | 47.21 | 10.00 | 43 | 105742 | 3192 | 56183090 |
Hallucinations, mixed | 46.24 | 10.00 | 49 | 105736 | 4375 | 56181907 |
Rhabdomyolysis | 45.65 | 10.00 | 174 | 105611 | 40484 | 56145798 |
Decreased appetite | 45.61 | 10.00 | 620 | 105165 | 218611 | 55967671 |
Ventricular fibrillation | 45.19 | 10.00 | 77 | 105708 | 10875 | 56175407 |
Delusion | 45.16 | 10.00 | 78 | 105707 | 11137 | 56175145 |
Poisoning deliberate | 45.12 | 10.00 | 73 | 105712 | 9880 | 56176402 |
Circulatory collapse | 45.00 | 10.00 | 112 | 105673 | 20691 | 56165591 |
Hip arthroplasty | 44.81 | 10.00 | 9 | 105776 | 38614 | 56147668 |
Muscle disorder | 44.46 | 10.00 | 49 | 105736 | 4574 | 56181708 |
Cough | 43.89 | 10.00 | 297 | 105488 | 259664 | 55926618 |
Therapeutic product ineffective | 43.38 | 10.00 | 29 | 105756 | 1363 | 56184919 |
Device expulsion | 42.59 | 10.00 | 4 | 105781 | 30445 | 56155837 |
Syncope | 42.44 | 10.00 | 348 | 105437 | 107851 | 56078431 |
Hypophagia | 42.34 | 10.00 | 135 | 105650 | 28741 | 56157541 |
Menstrual disorder | 42.30 | 10.00 | 48 | 105737 | 4627 | 56181655 |
Drug withdrawal syndrome neonatal | 42.22 | 10.00 | 33 | 105752 | 1983 | 56184299 |
Acute motor-sensory axonal neuropathy | 42.09 | 10.00 | 17 | 105768 | 272 | 56186010 |
Pain in extremity | 41.64 | 10.00 | 358 | 105427 | 297073 | 55889209 |
Abnormal behaviour | 41.62 | 10.00 | 107 | 105678 | 20165 | 56166117 |
Hypertonia neonatal | 41.30 | 10.00 | 16 | 105769 | 228 | 56186054 |
Panic attack | 41.03 | 10.00 | 107 | 105678 | 20340 | 56165942 |
Unresponsive to stimuli | 40.89 | 10.00 | 142 | 105643 | 31583 | 56154699 |
Chorea | 40.63 | 10.00 | 28 | 105757 | 1384 | 56184898 |
Psychomotor hyperactivity | 40.47 | 10.00 | 69 | 105716 | 9751 | 56176531 |
Sleep disorder | 40.31 | 10.00 | 241 | 105544 | 67422 | 56118860 |
Product dose omission issue | 39.71 | 10.00 | 224 | 105561 | 204529 | 55981753 |
Dysphagia | 39.69 | 10.00 | 277 | 105508 | 81670 | 56104612 |
Sleep paralysis | 39.58 | 10.00 | 20 | 105765 | 551 | 56185731 |
Product administration error | 39.44 | 10.00 | 107 | 105678 | 20822 | 56165460 |
Nasal congestion | 39.39 | 10.00 | 29 | 105756 | 56341 | 56129941 |
On and off phenomenon | 39.35 | 10.00 | 29 | 105756 | 1595 | 56184687 |
Off label use | 39.35 | 10.00 | 773 | 105012 | 555407 | 55630875 |
Panic reaction | 39.29 | 10.00 | 42 | 105743 | 3788 | 56182494 |
Anger | 39.16 | 10.00 | 75 | 105710 | 11597 | 56174685 |
Intentional product misuse | 39.13 | 10.00 | 196 | 105589 | 51308 | 56134974 |
Blood prolactin increased | 38.83 | 10.00 | 39 | 105746 | 3270 | 56183012 |
Hypoaesthesia oral | 37.79 | 10.00 | 73 | 105712 | 11358 | 56174924 |
Ill-defined disorder | 37.58 | 10.00 | 44 | 105741 | 68499 | 56117783 |
Bradykinesia | 37.56 | 10.00 | 46 | 105739 | 4808 | 56181474 |
Cyanosis | 37.28 | 10.00 | 88 | 105697 | 15722 | 56170560 |
Persecutory delusion | 37.19 | 10.00 | 34 | 105751 | 2536 | 56183746 |
Product prescribing error | 36.39 | 10.00 | 111 | 105674 | 23075 | 56163207 |
Galactorrhoea | 35.26 | 10.00 | 40 | 105745 | 3855 | 56182427 |
Generalised tonic-clonic seizure | 35.19 | 10.00 | 123 | 105662 | 27443 | 56158839 |
Aphasia | 34.83 | 10.00 | 131 | 105654 | 30284 | 56155998 |
Paranoia | 34.77 | 10.00 | 68 | 105717 | 10676 | 56175606 |
Asthma | 34.66 | 10.00 | 103 | 105682 | 112667 | 56073615 |
Hypokalaemia | 34.51 | 10.00 | 299 | 105486 | 94138 | 56092144 |
Irritability | 34.35 | 10.00 | 128 | 105657 | 29460 | 56156822 |
Coma scale abnormal | 34.30 | 10.00 | 44 | 105741 | 4819 | 56181463 |
Tonic clonic movements | 33.79 | 10.00 | 24 | 105761 | 1246 | 56185036 |
Aspiration | 33.73 | 10.00 | 63 | 105722 | 9558 | 56176724 |
Opisthotonus | 33.32 | 10.00 | 15 | 105770 | 317 | 56185965 |
Injection site bruising | 32.25 | 10.00 | 16 | 105769 | 38505 | 56147777 |
Erythema | 32.21 | 10.00 | 167 | 105618 | 155772 | 56030510 |
Abulia | 31.96 | 10.00 | 16 | 105769 | 432 | 56185850 |
Therapeutic product effect incomplete | 31.76 | 10.00 | 98 | 105687 | 105933 | 56080349 |
Neonatal asphyxia | 31.76 | 10.00 | 14 | 105771 | 281 | 56186001 |
Cardio-respiratory arrest | 31.65 | 10.00 | 195 | 105590 | 55126 | 56131156 |
Autonomic nervous system imbalance | 31.24 | 10.00 | 31 | 105754 | 2562 | 56183720 |
Respiratory arrest | 31.10 | 10.00 | 127 | 105658 | 30498 | 56155784 |
Bradypnoea | 30.89 | 10.00 | 34 | 105751 | 3169 | 56183113 |
Fracture | 30.89 | 10.00 | 89 | 105696 | 17929 | 56168353 |
Miosis | 30.77 | 10.00 | 49 | 105736 | 6543 | 56179739 |
Cognitive disorder | 30.55 | 10.00 | 177 | 105608 | 48956 | 56137326 |
Ballismus | 30.54 | 10.00 | 10 | 105775 | 84 | 56186198 |
Histrionic personality disorder | 30.53 | 10.00 | 9 | 105776 | 51 | 56186231 |
Immune reconstitution inflammatory syndrome | 30.46 | 10.00 | 45 | 105740 | 5629 | 56180653 |
Osteoarthritis | 30.35 | 10.00 | 66 | 105719 | 80230 | 56106052 |
Back pain | 30.33 | 10.00 | 292 | 105493 | 236878 | 55949404 |
Self-injurious ideation | 30.00 | 10.00 | 29 | 105756 | 2321 | 56183961 |
Psychotic symptom | 29.96 | 10.00 | 23 | 105762 | 1346 | 56184936 |
Haematemesis | 29.79 | 10.00 | 120 | 105665 | 28638 | 56157644 |
Rhonchi | 29.44 | 10.00 | 29 | 105756 | 2375 | 56183907 |
Bradyphrenia | 29.26 | 10.00 | 48 | 105737 | 6572 | 56179710 |
Merycism | 29.05 | 10.00 | 12 | 105773 | 204 | 56186078 |
Paralysis | 29.03 | 10.00 | 57 | 105728 | 8975 | 56177307 |
Chemical burn of oral cavity | 28.79 | 10.00 | 9 | 105776 | 64 | 56186218 |
Injection site swelling | 28.45 | 10.00 | 24 | 105761 | 43554 | 56142728 |
Sensory loss | 28.25 | 10.00 | 56 | 105729 | 8879 | 56177403 |
Affective disorder | 28.04 | 10.00 | 43 | 105742 | 5560 | 56180722 |
Phagophobia | 27.81 | 10.00 | 8 | 105777 | 41 | 56186241 |
Urinary hesitation | 27.59 | 10.00 | 26 | 105759 | 2016 | 56184266 |
Crush syndrome | 27.44 | 10.00 | 10 | 105775 | 119 | 56186163 |
Product monitoring error | 27.12 | 10.00 | 33 | 105752 | 3426 | 56182856 |
Euphoric mood | 26.99 | 10.00 | 37 | 105748 | 4321 | 56181961 |
Osteoporosis | 26.86 | 10.00 | 35 | 105750 | 52017 | 56134265 |
Anticholinergic syndrome | 26.85 | 10.00 | 25 | 105760 | 1909 | 56184373 |
Language disorder | 26.77 | 10.00 | 25 | 105760 | 1916 | 56184366 |
Epilepsy | 26.71 | 10.00 | 106 | 105679 | 25125 | 56161157 |
Acute psychosis | 26.67 | 10.00 | 27 | 105758 | 2285 | 56183997 |
Mental disorder | 26.48 | 10.00 | 101 | 105684 | 23503 | 56162779 |
Herpes zoster | 25.79 | 10.00 | 66 | 105719 | 75823 | 56110459 |
Hypotonia | 25.79 | 10.00 | 53 | 105732 | 8624 | 56177658 |
Swollen tongue | 25.63 | 10.00 | 119 | 105666 | 30205 | 56156077 |
Agranulocytosis | 25.46 | 10.00 | 97 | 105688 | 22562 | 56163720 |
Red blood cell sedimentation rate increased | 25.38 | 10.00 | 19 | 105766 | 36604 | 56149678 |
Social avoidant behaviour | 25.33 | 10.00 | 29 | 105756 | 2823 | 56183459 |
Helplessness | 25.30 | 10.00 | 12 | 105773 | 287 | 56185995 |
Foetal exposure during pregnancy | 25.19 | 10.00 | 128 | 105657 | 33695 | 56152587 |
Norepinephrine increased | 25.11 | 10.00 | 8 | 105777 | 61 | 56186221 |
Tongue movement disturbance | 25.07 | 10.00 | 12 | 105773 | 293 | 56185989 |
Newborn persistent pulmonary hypertension | 24.99 | 10.00 | 11 | 105774 | 220 | 56186062 |
Visceral congestion | 24.81 | 10.00 | 12 | 105773 | 300 | 56185982 |
Antipsychotic drug level decreased | 24.74 | 10.00 | 12 | 105773 | 302 | 56185980 |
Agitation neonatal | 24.68 | 10.00 | 14 | 105771 | 489 | 56185793 |
Blood bilirubin decreased | 24.52 | 10.00 | 16 | 105769 | 722 | 56185560 |
Neonatal hypoxia | 24.35 | 10.00 | 14 | 105771 | 502 | 56185780 |
Injection site reaction | 24.33 | 10.00 | 39 | 105746 | 53208 | 56133074 |
Emotional disorder | 24.32 | 10.00 | 64 | 105721 | 12231 | 56174051 |
Inflammation | 24.30 | 10.00 | 59 | 105726 | 69012 | 56117270 |
Thirst | 24.30 | 10.00 | 60 | 105725 | 11030 | 56175252 |
Systemic infection | 23.72 | 10.00 | 30 | 105755 | 3239 | 56183043 |
Therapy non-responder | 23.54 | 10.00 | 50 | 105735 | 61305 | 56124977 |
Sinus tachycardia | 23.52 | 10.00 | 94 | 105691 | 22350 | 56163932 |
Neonatal respiratory failure | 23.43 | 10.00 | 11 | 105774 | 257 | 56186025 |
Facial nerve disorder | 23.40 | 10.00 | 14 | 105771 | 541 | 56185741 |
Sensorimotor disorder | 23.37 | 10.00 | 13 | 105772 | 437 | 56185845 |
Hypotension | 23.29 | 10.00 | 626 | 105159 | 249882 | 55936400 |
Salivary hypersecretion | 23.28 | 10.00 | 45 | 105740 | 7005 | 56179277 |
CYP3A4 polymorphism | 23.20 | 10.00 | 8 | 105777 | 80 | 56186202 |
Respiratory disorder neonatal | 23.20 | 10.00 | 17 | 105768 | 927 | 56185355 |
Sudden death | 23.16 | 10.00 | 54 | 105731 | 9571 | 56176711 |
Incoherent | 23.13 | 10.00 | 34 | 105751 | 4235 | 56182047 |
Tachycardia paroxysmal | 23.12 | 10.00 | 11 | 105774 | 265 | 56186017 |
Orgasm abnormal | 23.11 | 10.00 | 8 | 105777 | 81 | 56186201 |
Substance abuse | 23.03 | 10.00 | 35 | 105750 | 4490 | 56181792 |
Fungal infection | 23.01 | 10.00 | 17 | 105768 | 32976 | 56153306 |
Tremor neonatal | 22.99 | 10.00 | 9 | 105776 | 132 | 56186150 |
Pneumonia aspiration | 22.98 | 10.00 | 121 | 105664 | 32290 | 56153992 |
Liver injury | 22.79 | 10.00 | 27 | 105758 | 41821 | 56144461 |
Alkalosis hypochloraemic | 22.69 | 10.00 | 9 | 105776 | 137 | 56186145 |
Pyelonephritis | 22.66 | 10.00 | 74 | 105711 | 15950 | 56170332 |
Postmortem blood drug level increased | 22.57 | 10.00 | 14 | 105771 | 578 | 56185704 |
Activation syndrome | 22.45 | 10.00 | 10 | 105775 | 206 | 56186076 |
Cerebral ventricle dilatation | 22.43 | 10.00 | 17 | 105768 | 976 | 56185306 |
Bursitis | 22.28 | 10.00 | 12 | 105773 | 27570 | 56158712 |
Gamma-glutamyltransferase increased | 22.16 | 10.00 | 116 | 105669 | 30889 | 56155393 |
Radial nerve palsy | 22.12 | 10.00 | 13 | 105772 | 486 | 56185796 |
Joint range of motion decreased | 22.06 | 10.00 | 10 | 105775 | 25355 | 56160927 |
Suicidal behaviour | 22.05 | 10.00 | 25 | 105760 | 2408 | 56183874 |
Upper respiratory tract infection | 21.98 | 10.00 | 65 | 105720 | 71223 | 56115059 |
Bipolar I disorder | 21.85 | 10.00 | 21 | 105764 | 1669 | 56184613 |
Abnormal weight gain | 21.84 | 10.00 | 20 | 105765 | 1495 | 56184787 |
Apathy | 21.80 | 10.00 | 47 | 105738 | 7907 | 56178375 |
Non-cardiogenic pulmonary oedema | 21.77 | 10.00 | 14 | 105771 | 616 | 56185666 |
Anaemia macrocytic | 21.77 | 10.00 | 28 | 105757 | 3075 | 56183207 |
Hepatocellular injury | 21.64 | 10.00 | 103 | 105682 | 26411 | 56159871 |
Sialoadenitis | 21.58 | 10.00 | 20 | 105765 | 1518 | 56184764 |
Blood sodium decreased | 21.41 | 10.00 | 91 | 105694 | 22243 | 56164039 |
Breast discomfort | 20.93 | 10.00 | 12 | 105773 | 428 | 56185854 |
Vagus nerve disorder | 20.91 | 10.00 | 8 | 105777 | 110 | 56186172 |
Orthostatic hypotension | 20.90 | 10.00 | 120 | 105665 | 33079 | 56153203 |
Cerebellar syndrome | 20.82 | 10.00 | 29 | 105756 | 3438 | 56182844 |
Mutism | 20.82 | 10.00 | 19 | 105766 | 1414 | 56184868 |
Retinal detachment | 20.81 | 10.00 | 37 | 105748 | 5404 | 56180878 |
Reduced facial expression | 20.77 | 10.00 | 21 | 105764 | 1775 | 56184507 |
Infantile vomiting | 20.71 | 10.00 | 8 | 105777 | 113 | 56186169 |
Giant cell arteritis | 20.59 | 10.00 | 22 | 105763 | 1983 | 56184299 |
Dementia | 20.57 | 10.00 | 75 | 105710 | 17083 | 56169199 |
Injection site haemorrhage | 20.51 | 10.00 | 8 | 105777 | 22193 | 56164089 |
Blood cholesterol increased | 20.40 | 10.00 | 69 | 105716 | 72510 | 56113772 |
Natural killer cell count decreased | 20.35 | 10.00 | 6 | 105779 | 34 | 56186248 |
Cerebral mass effect | 20.27 | 10.00 | 15 | 105770 | 830 | 56185452 |
Blood pressure increased | 20.16 | 10.00 | 175 | 105610 | 145001 | 56041281 |
Bradycardia neonatal | 20.08 | 10.00 | 15 | 105770 | 842 | 56185440 |
Vertigo | 20.04 | 10.00 | 173 | 105612 | 54399 | 56131883 |
Insomnia | 20.04 | 10.00 | 487 | 105298 | 191373 | 55994909 |
Thinking abnormal | 19.92 | 10.00 | 52 | 105733 | 9889 | 56176393 |
Rhinorrhoea | 19.85 | 10.00 | 49 | 105736 | 56988 | 56129294 |
Platelet count decreased | 19.74 | 10.00 | 118 | 105667 | 106265 | 56080017 |
Akinesia | 19.69 | 10.00 | 19 | 105766 | 1517 | 56184765 |
Neuropathy peripheral | 19.69 | 10.00 | 113 | 105672 | 102780 | 56083502 |
Labelled drug-drug interaction medication error | 19.64 | 10.00 | 57 | 105728 | 11529 | 56174753 |
Thymus disorder | 19.48 | 10.00 | 10 | 105775 | 285 | 56185997 |
Cataract | 19.47 | 10.00 | 42 | 105743 | 51205 | 56135077 |
Purple glove syndrome | 19.42 | 10.00 | 9 | 105776 | 204 | 56186078 |
Hyperthermia | 19.41 | 10.00 | 46 | 105739 | 8239 | 56178043 |
Stoma site discharge | 19.23 | 10.00 | 18 | 105767 | 1384 | 56184898 |
Tinnitus | 19.18 | 10.00 | 109 | 105676 | 29933 | 56156349 |
Mental impairment | 19.12 | 10.00 | 60 | 105725 | 12662 | 56173620 |
Vitamin B12 decreased | 18.88 | 10.00 | 26 | 105759 | 3049 | 56183233 |
Skin exfoliation | 18.85 | 10.00 | 25 | 105760 | 36875 | 56149407 |
Status epilepticus | 18.84 | 10.00 | 67 | 105718 | 15074 | 56171208 |
COVID-19 | 18.70 | 10.00 | 75 | 105710 | 74983 | 56111299 |
Bulimia nervosa | 18.67 | 10.00 | 11 | 105774 | 413 | 56185869 |
Tachyphrenia | 18.60 | 10.00 | 17 | 105768 | 1267 | 56185015 |
Freezing phenomenon | 18.60 | 10.00 | 16 | 105769 | 1101 | 56185181 |
Drop attacks | 18.59 | 10.00 | 13 | 105772 | 658 | 56185624 |
Hypotonia neonatal | 18.51 | 10.00 | 16 | 105769 | 1108 | 56185174 |
Neglect of personal appearance | 18.44 | 10.00 | 7 | 105778 | 94 | 56186188 |
Acute abdomen | 18.44 | 10.00 | 18 | 105767 | 1458 | 56184824 |
Musculoskeletal stiffness | 18.30 | 10.00 | 196 | 105589 | 155811 | 56030471 |
False positive investigation result | 18.22 | 10.00 | 12 | 105773 | 550 | 56185732 |
Suspected suicide | 18.18 | 10.00 | 35 | 105750 | 5431 | 56180851 |
Illusion | 18.12 | 10.00 | 15 | 105770 | 979 | 56185303 |
Drug reaction with eosinophilia and systemic symptoms | 18.08 | 10.00 | 108 | 105677 | 30196 | 56156086 |
Anaphylactic reaction | 18.04 | 10.00 | 54 | 105731 | 58941 | 56127341 |
Serum serotonin increased | 17.99 | 10.00 | 8 | 105777 | 164 | 56186118 |
Skin ulcer | 17.90 | 10.00 | 28 | 105757 | 38580 | 56147702 |
Bundle branch block right | 17.80 | 10.00 | 32 | 105753 | 4715 | 56181567 |
Hallucination, synaesthetic | 17.77 | 10.00 | 6 | 105779 | 56 | 56186226 |
Cytomegalovirus infection | 17.75 | 10.00 | 7 | 105778 | 19289 | 56166993 |
Bipolar disorder | 17.66 | 10.00 | 42 | 105743 | 7538 | 56178744 |
Compulsive shopping | 17.66 | 10.00 | 13 | 105772 | 714 | 56185568 |
Agonal rhythm | 17.65 | 10.00 | 5 | 105780 | 24 | 56186258 |
Tearfulness | 17.58 | 10.00 | 28 | 105757 | 3740 | 56182542 |
Febrile neutropenia | 17.57 | 10.00 | 121 | 105664 | 105424 | 56080858 |
Upper gastrointestinal haemorrhage | 17.53 | 10.00 | 71 | 105714 | 16983 | 56169299 |
Pyroglutamic acidosis | 17.50 | 10.00 | 11 | 105774 | 465 | 56185817 |
Brief psychotic disorder with marked stressors | 17.49 | 10.00 | 6 | 105779 | 59 | 56186223 |
Negative thoughts | 17.48 | 10.00 | 14 | 105771 | 872 | 56185410 |
Adverse event | 17.43 | 10.00 | 50 | 105735 | 55326 | 56130956 |
Nephrolithiasis | 17.39 | 10.00 | 27 | 105758 | 37308 | 56148974 |
Cellulitis orbital | 17.35 | 10.00 | 11 | 105774 | 472 | 56185810 |
Snoring | 17.24 | 10.00 | 27 | 105758 | 3554 | 56182728 |
Macular degeneration | 17.16 | 10.00 | 7 | 105778 | 18901 | 56167381 |
Therapeutic response decreased | 17.08 | 10.00 | 47 | 105738 | 52711 | 56133571 |
Medication error | 17.03 | 10.00 | 137 | 105648 | 42198 | 56144084 |
Drug dose titration not performed | 16.96 | 10.00 | 11 | 105774 | 491 | 56185791 |
Balance disorder | 16.95 | 10.00 | 219 | 105566 | 76301 | 56109981 |
Lower limb fracture | 16.92 | 10.00 | 6 | 105779 | 17649 | 56168633 |
Premature labour | 16.91 | 10.00 | 55 | 105730 | 11827 | 56174455 |
Hyperreflexia | 16.71 | 10.00 | 33 | 105752 | 5217 | 56181065 |
Pulmonary renal syndrome | 16.47 | 10.00 | 10 | 105775 | 397 | 56185885 |
Spina bifida | 16.43 | 10.00 | 13 | 105772 | 795 | 56185487 |
Premature delivery | 16.36 | 10.00 | 16 | 105769 | 27044 | 56159238 |
Respiratory depression | 16.32 | 10.00 | 56 | 105729 | 12379 | 56173903 |
Aptyalism | 16.31 | 10.00 | 11 | 105774 | 525 | 56185757 |
Post-traumatic stress disorder | 16.27 | 10.00 | 30 | 105755 | 4508 | 56181774 |
Wheezing | 16.25 | 10.00 | 79 | 105706 | 74947 | 56111335 |
Homicidal ideation | 16.25 | 10.00 | 18 | 105767 | 1690 | 56184592 |
Hypothermia | 16.22 | 10.00 | 56 | 105729 | 12414 | 56173868 |
Blood pressure diastolic decreased | 16.21 | 10.00 | 8 | 105777 | 19315 | 56166967 |
Stoma site inflammation | 16.20 | 10.00 | 10 | 105775 | 409 | 56185873 |
Binge eating | 16.16 | 10.00 | 10 | 105775 | 411 | 56185871 |
Hyperacusis | 16.11 | 10.00 | 19 | 105766 | 1909 | 56184373 |
Faecaloma | 16.03 | 10.00 | 40 | 105745 | 7401 | 56178881 |
Empty sella syndrome | 15.94 | 10.00 | 5 | 105780 | 36 | 56186246 |
Cardiac hypertrophy | 15.86 | 10.00 | 14 | 105771 | 997 | 56185285 |
Injection site rash | 15.85 | 10.00 | 6 | 105779 | 16952 | 56169330 |
Fibromyalgia | 15.85 | 10.00 | 58 | 105727 | 59545 | 56126737 |
Essential tremor | 15.72 | 10.00 | 14 | 105771 | 1009 | 56185273 |
Medulloblastoma | 15.71 | 10.00 | 5 | 105780 | 38 | 56186244 |
Gastrooesophageal reflux disease | 15.63 | 10.00 | 92 | 105693 | 83165 | 56103117 |
Alcoholism | 15.60 | 10.00 | 20 | 105765 | 2189 | 56184093 |
Aspartate aminotransferase decreased | 15.56 | 10.00 | 12 | 105773 | 707 | 56185575 |
Pulse absent | 15.55 | 10.00 | 31 | 105754 | 4936 | 56181346 |
Decubitus ulcer | 15.53 | 10.00 | 47 | 105738 | 9728 | 56176554 |
Parkinsonian gait | 15.49 | 10.00 | 10 | 105775 | 443 | 56185839 |
Torsade de pointes | 15.44 | 10.00 | 55 | 105730 | 12385 | 56173897 |
Drowning | 15.43 | 10.00 | 10 | 105775 | 446 | 56185836 |
Loss of libido | 15.30 | 10.00 | 15 | 105770 | 1221 | 56185061 |
Aspergillus test positive | 15.30 | 10.00 | 9 | 105776 | 337 | 56185945 |
Catatonia | 15.22 | 10.00 | 27 | 105758 | 3937 | 56182345 |
Death | 15.04 | 10.00 | 785 | 105000 | 340641 | 55845641 |
Vasodilatation | 14.82 | 10.00 | 20 | 105765 | 2301 | 56183981 |
Refusal of treatment by patient | 14.82 | 10.00 | 31 | 105754 | 5107 | 56181175 |
Resuscitation | 14.82 | 10.00 | 14 | 105771 | 1089 | 56185193 |
Enterococcus test positive | 14.78 | 10.00 | 14 | 105771 | 1092 | 56185190 |
Skull fracture | 14.76 | 10.00 | 13 | 105772 | 923 | 56185359 |
Granulocytopenia neonatal | 14.71 | 10.00 | 4 | 105781 | 16 | 56186266 |
Dyspraxia | 14.68 | 10.00 | 8 | 105777 | 258 | 56186024 |
Transferrin saturation decreased | 14.63 | 10.00 | 11 | 105774 | 624 | 56185658 |
Logorrhoea | 14.61 | 10.00 | 20 | 105765 | 2332 | 56183950 |
Developmental hip dysplasia | 14.56 | 10.00 | 15 | 105770 | 1296 | 56184986 |
Eyelid myoclonus | 14.52 | 10.00 | 6 | 105779 | 102 | 56186180 |
Palmar-plantar erythrodysaesthesia syndrome | 14.50 | 10.00 | 11 | 105774 | 21054 | 56165228 |
Antidepressant drug level increased | 14.49 | 10.00 | 8 | 105777 | 265 | 56186017 |
Exostosis | 14.46 | 10.00 | 5 | 105780 | 14938 | 56171344 |
Neck pain | 14.41 | 10.00 | 63 | 105722 | 61492 | 56124790 |
Pneumonia | 14.39 | 10.00 | 622 | 105163 | 406476 | 55779806 |
Pulmonary vein occlusion | 14.36 | 10.00 | 6 | 105779 | 105 | 56186177 |
Thyroxine free decreased | 14.34 | 10.00 | 11 | 105774 | 643 | 56185639 |
Basophil count decreased | 14.31 | 10.00 | 6 | 105779 | 106 | 56186176 |
Psychiatric decompensation | 14.31 | 10.00 | 15 | 105770 | 1323 | 56184959 |
Gait disturbance | 14.27 | 10.00 | 405 | 105380 | 162916 | 56023366 |
Tenosynovitis | 14.25 | 10.00 | 3 | 105782 | 12458 | 56173824 |
Parkinson's disease | 14.25 | 10.00 | 15 | 105770 | 1329 | 56184953 |
Myocardial infarction | 14.24 | 10.00 | 109 | 105676 | 92761 | 56093521 |
Interstitial lung disease | 14.22 | 10.00 | 57 | 105728 | 57006 | 56129276 |
Ear infection | 14.22 | 10.00 | 23 | 105762 | 31272 | 56155010 |
Intrusive thoughts | 14.22 | 10.00 | 7 | 105778 | 182 | 56186100 |
Skin necrosis | 14.09 | 10.00 | 3 | 105782 | 12358 | 56173924 |
Extensor plantar response | 14.02 | 10.00 | 14 | 105771 | 1166 | 56185116 |
Liver disorder | 14.01 | 10.00 | 40 | 105745 | 44330 | 56141952 |
Sinus congestion | 13.99 | 10.00 | 6 | 105779 | 15718 | 56170564 |
Therapeutic drug monitoring analysis not performed | 13.97 | 10.00 | 13 | 105772 | 992 | 56185290 |
Indifference | 13.96 | 10.00 | 6 | 105779 | 113 | 56186169 |
B-lymphocyte count increased | 13.96 | 10.00 | 6 | 105779 | 113 | 56186169 |
Dystrophic calcification | 13.91 | 10.00 | 6 | 105779 | 114 | 56186168 |
Creatinine renal clearance decreased | 13.86 | 10.00 | 5 | 105780 | 14554 | 56171728 |
Maternal drugs affecting foetus | 13.85 | 10.00 | 30 | 105755 | 5063 | 56181219 |
Shared psychotic disorder | 13.82 | 10.00 | 4 | 105781 | 21 | 56186261 |
Congenital hand malformation | 13.81 | 10.00 | 8 | 105777 | 291 | 56185991 |
Product quality issue | 13.80 | 10.00 | 24 | 105761 | 31712 | 56154570 |
Stoma site hypergranulation | 13.79 | 10.00 | 8 | 105777 | 292 | 56185990 |
Dysdiadochokinesis | 13.77 | 10.00 | 6 | 105779 | 117 | 56186165 |
Intestinal mucosal atrophy | 13.76 | 10.00 | 3 | 105782 | 3 | 56186279 |
Spontaneous haemorrhage | 13.76 | 10.00 | 8 | 105777 | 293 | 56185989 |
Compulsive sexual behaviour | 13.76 | 10.00 | 5 | 105780 | 59 | 56186223 |
Respiratory distress | 13.72 | 10.00 | 24 | 105761 | 31643 | 56154639 |
Migraine | 13.72 | 10.00 | 101 | 105684 | 86696 | 56099586 |
Stupor | 13.70 | 10.00 | 26 | 105759 | 3992 | 56182290 |
Optic nerve disorder | 13.65 | 10.00 | 11 | 105774 | 691 | 56185591 |
Polydipsia psychogenic | 13.61 | 10.00 | 5 | 105780 | 61 | 56186221 |
Anal infection | 13.61 | 10.00 | 5 | 105780 | 61 | 56186221 |
Personality disorder | 13.53 | 10.00 | 30 | 105755 | 5143 | 56181139 |
Fluid retention | 13.49 | 10.00 | 54 | 105731 | 54024 | 56132258 |
Mobility decreased | 13.44 | 10.00 | 120 | 105665 | 98871 | 56087411 |
Dyspnoea at rest | 13.41 | 10.00 | 25 | 105760 | 3788 | 56182494 |
Somatic delusion | 13.38 | 10.00 | 10 | 105775 | 562 | 56185720 |
Chest pain | 13.28 | 10.00 | 264 | 105521 | 189533 | 55996749 |
Bradycardia | 13.23 | 10.00 | 189 | 105596 | 67315 | 56118967 |
Rabbit syndrome | 13.21 | 10.00 | 8 | 105777 | 316 | 56185966 |
C-reactive protein increased | 13.20 | 10.00 | 90 | 105695 | 78594 | 56107688 |
Long QT syndrome | 13.19 | 10.00 | 22 | 105763 | 3054 | 56183228 |
Viral infection | 13.14 | 10.00 | 25 | 105760 | 31921 | 56154361 |
Retrograde amnesia | 13.11 | 10.00 | 9 | 105776 | 442 | 56185840 |
Abdominal pain upper | 13.10 | 10.00 | 246 | 105539 | 178067 | 56008215 |
Orthostatic intolerance | 13.08 | 10.00 | 13 | 105772 | 1076 | 56185206 |
Selective eating disorder | 13.07 | 10.00 | 17 | 105768 | 1887 | 56184395 |
Tendonitis | 13.05 | 10.00 | 9 | 105776 | 18088 | 56168194 |
Increased appetite | 12.95 | 10.00 | 41 | 105744 | 8694 | 56177588 |
Blood pressure diastolic abnormal | 12.85 | 10.00 | 3 | 105782 | 11595 | 56174687 |
Kussmaul respiration | 12.81 | 10.00 | 7 | 105778 | 227 | 56186055 |
Generalised anxiety disorder | 12.79 | 10.00 | 17 | 105768 | 1927 | 56184355 |
Paranasal sinus inflammation | 12.78 | 10.00 | 9 | 105776 | 461 | 56185821 |
Pyrexia | 12.77 | 10.00 | 650 | 105135 | 418123 | 55768159 |
Arrhythmia | 12.77 | 10.00 | 111 | 105674 | 34972 | 56151310 |
Glassy eyes | 12.73 | 10.00 | 5 | 105780 | 74 | 56186208 |
Dreamy state | 12.73 | 10.00 | 4 | 105781 | 29 | 56186253 |
Somnambulism | 12.73 | 10.00 | 29 | 105756 | 5063 | 56181219 |
Influenza | 12.70 | 10.00 | 116 | 105669 | 95145 | 56091137 |
Mixed anxiety and depressive disorder | 12.70 | 10.00 | 7 | 105778 | 231 | 56186051 |
Clonus | 12.68 | 10.00 | 26 | 105759 | 4223 | 56182059 |
Breast cancer | 12.67 | 10.00 | 48 | 105737 | 48785 | 56137497 |
Obsessive-compulsive disorder | 12.66 | 10.00 | 24 | 105761 | 3682 | 56182600 |
Nail avulsion | 12.63 | 10.00 | 6 | 105779 | 144 | 56186138 |
Lipohypertrophy | 12.61 | 10.00 | 10 | 105775 | 614 | 56185668 |
Visual acuity reduced transiently | 12.59 | 10.00 | 6 | 105779 | 145 | 56186137 |
Gambling | 12.57 | 10.00 | 7 | 105778 | 236 | 56186046 |
Fibula agenesis | 12.55 | 10.00 | 3 | 105782 | 6 | 56186276 |
Agoraphobia | 12.48 | 10.00 | 8 | 105777 | 350 | 56185932 |
Bronchitis | 12.41 | 10.00 | 143 | 105642 | 112168 | 56074114 |
Acute kidney injury | 12.36 | 10.00 | 562 | 105223 | 240201 | 55946081 |
Heart rate decreased | 12.36 | 10.00 | 37 | 105748 | 40390 | 56145892 |
Abdominal rigidity | 12.35 | 10.00 | 16 | 105769 | 1769 | 56184513 |
Paraesthesia | 12.35 | 10.00 | 327 | 105458 | 130187 | 56056095 |
Regressive behaviour | 12.33 | 10.00 | 6 | 105779 | 152 | 56186130 |
Phaeochromocytoma | 12.29 | 10.00 | 9 | 105776 | 490 | 56185792 |
Transfusion | 12.28 | 10.00 | 5 | 105780 | 13515 | 56172767 |
Dry mouth | 12.28 | 10.00 | 179 | 105606 | 64026 | 56122256 |
Poor feeding infant | 12.23 | 10.00 | 7 | 105778 | 249 | 56186033 |
Hyperphagia | 12.15 | 10.00 | 15 | 105770 | 1581 | 56184701 |
Cerebellar haematoma | 12.14 | 10.00 | 8 | 105777 | 367 | 56185915 |
Product complaint | 12.12 | 10.00 | 49 | 105736 | 11711 | 56174571 |
Chemical burns of eye | 12.10 | 10.00 | 5 | 105780 | 85 | 56186197 |
No adverse event | 12.07 | 10.00 | 32 | 105753 | 36342 | 56149940 |
Cardiac failure congestive | 12.06 | 10.00 | 106 | 105679 | 87614 | 56098668 |
Antiphospholipid antibodies | 12.05 | 10.00 | 6 | 105779 | 160 | 56186122 |
Obsessive-compulsive symptom | 12.05 | 10.00 | 5 | 105780 | 86 | 56186196 |
Ear pain | 11.99 | 10.00 | 25 | 105760 | 30865 | 56155417 |
Basal cell carcinoma | 11.97 | 10.00 | 18 | 105767 | 25203 | 56161079 |
Snake bite | 11.95 | 10.00 | 3 | 105782 | 8 | 56186274 |
Communication disorder | 11.93 | 10.00 | 18 | 105767 | 2295 | 56183987 |
Flushing | 11.85 | 10.00 | 80 | 105705 | 70020 | 56116262 |
Inappropriate affect | 11.83 | 10.00 | 11 | 105774 | 838 | 56185444 |
Mucosal inflammation | 11.82 | 10.00 | 41 | 105744 | 42769 | 56143513 |
Somatic symptom disorder | 11.81 | 10.00 | 17 | 105768 | 2078 | 56184204 |
Injection site warmth | 11.80 | 10.00 | 6 | 105779 | 14237 | 56172045 |
Failure to thrive | 11.79 | 10.00 | 33 | 105752 | 6537 | 56179745 |
Ataxia | 11.79 | 10.00 | 56 | 105729 | 14347 | 56171935 |
Cerebral atrophy | 11.77 | 10.00 | 27 | 105758 | 4733 | 56181549 |
Productive cough | 11.72 | 10.00 | 60 | 105725 | 56172 | 56130110 |
Sinus disorder | 11.70 | 10.00 | 13 | 105772 | 20721 | 56165561 |
Product confusion | 11.69 | 10.00 | 3 | 105782 | 9 | 56186273 |
Peripheral paralysis | 11.69 | 10.00 | 5 | 105780 | 93 | 56186189 |
Haemoptysis | 11.63 | 10.00 | 20 | 105765 | 26540 | 56159742 |
Polyneuropathy | 11.61 | 10.00 | 52 | 105733 | 12998 | 56173284 |
Joint injury | 11.52 | 10.00 | 19 | 105766 | 25635 | 56160647 |
Formication | 11.50 | 10.00 | 24 | 105761 | 3946 | 56182336 |
Tic | 11.42 | 10.00 | 13 | 105772 | 1258 | 56185024 |
Dizziness | 11.39 | 10.00 | 837 | 104948 | 375303 | 55810979 |
Infantile apnoea | 11.38 | 10.00 | 11 | 105774 | 880 | 56185402 |
Antipsychotic drug level below therapeutic | 11.35 | 10.00 | 7 | 105778 | 286 | 56185996 |
Blood pressure systolic increased | 11.35 | 10.00 | 39 | 105746 | 40797 | 56145485 |
Labelled drug-disease interaction issue | 11.26 | 10.00 | 4 | 105781 | 44 | 56186238 |
Oedema | 11.25 | 10.00 | 99 | 105686 | 81821 | 56104461 |
Injection site urticaria | 11.18 | 10.00 | 5 | 105780 | 12778 | 56173504 |
Secretion discharge | 11.16 | 10.00 | 3 | 105782 | 10543 | 56175739 |
Food craving | 11.12 | 10.00 | 14 | 105771 | 1505 | 56184777 |
Ocular hyperaemia | 11.11 | 10.00 | 15 | 105770 | 21964 | 56164318 |
Central nervous system inflammation | 11.11 | 10.00 | 6 | 105779 | 190 | 56186092 |
Potentiating drug interaction | 11.11 | 10.00 | 24 | 105761 | 4042 | 56182240 |
Contusion | 11.11 | 10.00 | 172 | 105613 | 128258 | 56058024 |
Staphylococcal infection | 11.09 | 10.00 | 35 | 105750 | 37583 | 56148699 |
Electrocardiogram abnormal | 10.97 | 10.00 | 37 | 105748 | 8107 | 56178175 |
Post viral fatigue syndrome | 10.97 | 10.00 | 7 | 105778 | 304 | 56185978 |
Sleep terror | 10.94 | 10.00 | 10 | 105775 | 746 | 56185536 |
Adrenal cyst | 10.92 | 10.00 | 5 | 105780 | 110 | 56186172 |
Arachnoid cyst | 10.91 | 10.00 | 6 | 105779 | 197 | 56186085 |
Anaphylactic shock | 10.83 | 10.00 | 15 | 105770 | 21725 | 56164557 |
Pulmonary haematoma | 10.80 | 10.00 | 4 | 105781 | 50 | 56186232 |
Decreased interest | 10.75 | 10.00 | 20 | 105765 | 3026 | 56183256 |
Skin lesion | 10.73 | 10.00 | 23 | 105762 | 28112 | 56158170 |
Crying | 10.68 | 10.00 | 73 | 105712 | 21367 | 56164915 |
Hypernatraemia | 10.68 | 10.00 | 32 | 105753 | 6588 | 56179694 |
Eye irritation | 10.66 | 10.00 | 12 | 105773 | 19016 | 56167266 |
Hemianopia homonymous | 10.63 | 10.00 | 9 | 105776 | 606 | 56185676 |
Electrocardiogram T wave inversion | 10.63 | 10.00 | 21 | 105764 | 3322 | 56182960 |
Blood alkaline phosphatase increased | 10.62 | 10.00 | 116 | 105669 | 38829 | 56147453 |
Compulsions | 10.62 | 10.00 | 6 | 105779 | 208 | 56186074 |
Therapy interrupted | 10.59 | 10.00 | 20 | 105765 | 25605 | 56160677 |
Grip strength decreased | 10.55 | 10.00 | 9 | 105776 | 16247 | 56170035 |
Poverty of thought content | 10.49 | 10.00 | 3 | 105782 | 15 | 56186267 |
Rash pruritic | 10.47 | 10.00 | 57 | 105728 | 52537 | 56133745 |
Pharyngeal erythema | 10.44 | 10.00 | 14 | 105771 | 1601 | 56184681 |
Immunodeficiency | 10.42 | 10.00 | 9 | 105776 | 16148 | 56170134 |
Acquired epidermolysis bullosa | 10.39 | 10.00 | 4 | 105781 | 56 | 56186226 |
Large for dates baby | 10.38 | 10.00 | 8 | 105777 | 471 | 56185811 |
Foot deformity | 10.37 | 10.00 | 18 | 105767 | 23807 | 56162475 |
Bifascicular block | 10.34 | 10.00 | 5 | 105780 | 125 | 56186157 |
Hyporesponsive to stimuli | 10.34 | 10.00 | 11 | 105774 | 987 | 56185295 |
Disseminated intravascular coagulation | 10.33 | 10.00 | 11 | 105774 | 17874 | 56168408 |
Acute myeloid leukaemia | 10.30 | 10.00 | 10 | 105775 | 16962 | 56169320 |
Granulocyte percentage | 10.26 | 10.00 | 4 | 105781 | 58 | 56186224 |
Drug withdrawal headache | 10.26 | 10.00 | 4 | 105781 | 58 | 56186224 |
Personality change | 10.23 | 10.00 | 29 | 105756 | 5788 | 56180494 |
Neuropsychiatric symptoms | 10.18 | 10.00 | 9 | 105776 | 642 | 56185640 |
Postural tremor | 10.14 | 10.00 | 6 | 105779 | 227 | 56186055 |
Glomerular filtration rate decreased | 10.14 | 10.00 | 48 | 105737 | 12281 | 56174001 |
Metamyelocyte count increased | 10.12 | 10.00 | 6 | 105779 | 228 | 56186054 |
Gamma-glutamyltransferase abnormal | 10.12 | 10.00 | 6 | 105779 | 228 | 56186054 |
Acne | 10.12 | 10.00 | 15 | 105770 | 21121 | 56165161 |
Ocular discomfort | 10.07 | 10.00 | 22 | 105763 | 3733 | 56182549 |
Osteomyelitis | 10.06 | 10.00 | 19 | 105766 | 24327 | 56161955 |
Rash erythematous | 10.04 | 10.00 | 36 | 105749 | 37185 | 56149097 |
HIV-associated neurocognitive disorder | 10.02 | 10.00 | 5 | 105780 | 134 | 56186148 |
Pulmonary fibrosis | 10.01 | 10.00 | 26 | 105759 | 29732 | 56156550 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Toxicity to various agents | 496.56 | 10.50 | 1208 | 71773 | 180279 | 31444084 |
Intentional overdose | 440.28 | 10.50 | 509 | 72472 | 40880 | 31583483 |
Intentional self-injury | 377.09 | 10.50 | 283 | 72698 | 13032 | 31611331 |
Suicide attempt | 354.69 | 10.50 | 433 | 72548 | 36815 | 31587548 |
Completed suicide | 347.97 | 10.50 | 696 | 72285 | 90818 | 31533545 |
Serotonin syndrome | 283.03 | 10.50 | 278 | 72703 | 18495 | 31605868 |
Suicidal ideation | 278.78 | 10.50 | 380 | 72601 | 36026 | 31588337 |
Agitation | 272.44 | 10.50 | 465 | 72516 | 53704 | 31570659 |
Confusional state | 217.59 | 10.50 | 738 | 72243 | 132596 | 31491767 |
Somnolence | 216.71 | 10.50 | 609 | 72372 | 98836 | 31525527 |
Drug abuse | 211.75 | 10.50 | 558 | 72423 | 87200 | 31537163 |
Overdose | 205.97 | 10.50 | 540 | 72441 | 84124 | 31540239 |
Sopor | 170.23 | 10.50 | 169 | 72812 | 11383 | 31612980 |
Anxiety | 162.75 | 10.50 | 520 | 72461 | 90513 | 31533850 |
Coma | 153.72 | 10.50 | 311 | 72670 | 40839 | 31583524 |
Depression | 153.55 | 10.50 | 509 | 72472 | 90306 | 31534057 |
Restlessness | 142.46 | 10.50 | 219 | 72762 | 23142 | 31601221 |
Extrapyramidal disorder | 142.43 | 10.50 | 155 | 72826 | 11623 | 31612740 |
Sedation | 125.91 | 10.50 | 185 | 72796 | 18780 | 31605583 |
Aggression | 120.87 | 10.50 | 266 | 72715 | 37025 | 31587338 |
Drug interaction | 106.93 | 10.50 | 833 | 72148 | 207710 | 31416653 |
Hallucination, visual | 103.30 | 10.50 | 153 | 72828 | 15641 | 31608722 |
Fall | 103.07 | 10.50 | 757 | 72224 | 185332 | 31439031 |
Intrusive thoughts | 100.19 | 10.50 | 34 | 72947 | 257 | 31624106 |
Delirium | 99.35 | 10.50 | 263 | 72718 | 41158 | 31583205 |
Restless legs syndrome | 98.92 | 10.50 | 105 | 72876 | 7651 | 31616712 |
Drug withdrawal syndrome | 98.16 | 10.50 | 164 | 72817 | 18586 | 31605777 |
Neuroleptic malignant syndrome | 95.69 | 10.50 | 153 | 72828 | 16716 | 31607647 |
Withdrawal syndrome | 92.18 | 10.50 | 124 | 72857 | 11593 | 31612770 |
Depressed mood | 91.04 | 10.50 | 153 | 72828 | 17422 | 31606941 |
Nightmare | 90.27 | 10.50 | 125 | 72856 | 12012 | 31612351 |
Febrile neutropenia | 89.62 | 10.50 | 89 | 72892 | 121760 | 31502603 |
Accidental overdose | 88.81 | 10.50 | 155 | 72826 | 18195 | 31606168 |
Insomnia | 85.58 | 10.50 | 438 | 72543 | 94398 | 31529965 |
Tremor | 84.23 | 10.50 | 374 | 72607 | 76046 | 31548317 |
Electrocardiogram QT prolonged | 83.89 | 10.50 | 234 | 72747 | 37753 | 31586610 |
Hallucination, auditory | 83.58 | 10.50 | 111 | 72870 | 10249 | 31614114 |
Psychotic disorder | 81.44 | 10.50 | 167 | 72814 | 22126 | 31602237 |
Mania | 79.75 | 10.50 | 102 | 72879 | 9075 | 31615288 |
Akathisia | 76.66 | 10.50 | 89 | 72892 | 7164 | 31617199 |
Parkinsonism | 74.59 | 10.50 | 90 | 72891 | 7546 | 31616817 |
Bradyphrenia | 73.48 | 10.50 | 69 | 72912 | 4335 | 31620028 |
Depressed level of consciousness | 72.07 | 10.50 | 224 | 72757 | 38377 | 31585986 |
Disorientation | 70.47 | 10.50 | 192 | 72789 | 30552 | 31593811 |
Dyskinesia | 67.55 | 10.50 | 149 | 72832 | 20761 | 31603602 |
Logorrhoea | 67.20 | 10.50 | 50 | 72931 | 2269 | 31622094 |
Wrong patient received product | 67.15 | 10.50 | 52 | 72929 | 2507 | 31621856 |
Pneumonia aspiration | 64.39 | 10.50 | 216 | 72765 | 38510 | 31585853 |
Progressive multifocal leukoencephalopathy | 64.23 | 10.50 | 92 | 72889 | 9121 | 31615242 |
Abnormal behaviour | 64.06 | 10.50 | 158 | 72823 | 23670 | 31600693 |
Paranoia | 62.99 | 10.50 | 98 | 72883 | 10457 | 31613906 |
Tachyphrenia | 61.29 | 10.50 | 37 | 72944 | 1180 | 31623183 |
Antidepressant drug level above therapeutic | 60.80 | 10.50 | 22 | 72959 | 205 | 31624158 |
Homicidal ideation | 60.16 | 10.50 | 49 | 72932 | 2542 | 31621821 |
Myoclonus | 59.83 | 10.50 | 112 | 72869 | 13878 | 31610485 |
Muscle twitching | 58.58 | 10.50 | 83 | 72898 | 8147 | 31616216 |
Interstitial lung disease | 57.59 | 10.50 | 35 | 72946 | 61368 | 31562995 |
Hallucination | 57.17 | 10.50 | 235 | 72746 | 46175 | 31578188 |
Disturbance in attention | 56.31 | 10.50 | 145 | 72836 | 22305 | 31602058 |
Rheumatoid arthritis | 56.02 | 10.50 | 20 | 72961 | 47789 | 31576574 |
Psychomotor hyperactivity | 53.02 | 10.50 | 82 | 72899 | 8705 | 31615658 |
Inappropriate antidiuretic hormone secretion | 52.27 | 10.50 | 94 | 72887 | 11293 | 31613070 |
Panic attack | 52.21 | 10.50 | 81 | 72900 | 8622 | 31615741 |
Poisoning | 51.88 | 10.50 | 89 | 72892 | 10302 | 31614061 |
Pruritus | 51.74 | 10.50 | 134 | 72847 | 125033 | 31499330 |
Apathy | 51.59 | 10.50 | 69 | 72912 | 6413 | 31617950 |
Sleep disorder | 51.13 | 10.50 | 155 | 72826 | 26193 | 31598170 |
Delusion | 50.00 | 10.50 | 95 | 72886 | 11902 | 31612461 |
Muscle rigidity | 48.40 | 10.50 | 84 | 72897 | 9813 | 31614550 |
Tachycardia | 47.89 | 10.50 | 320 | 72661 | 75887 | 31548476 |
Poisoning deliberate | 47.80 | 10.50 | 71 | 72910 | 7273 | 31617090 |
Hypomania | 47.18 | 10.50 | 40 | 72941 | 2195 | 31622168 |
On and off phenomenon | 47.10 | 10.50 | 39 | 72942 | 2071 | 31622292 |
Bradykinesia | 46.46 | 10.50 | 49 | 72932 | 3543 | 31620820 |
Loss of consciousness | 46.34 | 10.50 | 321 | 72660 | 77034 | 31547329 |
Mood swings | 45.80 | 10.50 | 70 | 72911 | 7354 | 31617009 |
Analgesic drug level above therapeutic | 44.79 | 10.50 | 19 | 72962 | 279 | 31624084 |
Systemic infection | 44.52 | 10.50 | 47 | 72934 | 3402 | 31620961 |
Nasopharyngitis | 43.31 | 10.50 | 49 | 72932 | 63196 | 31561167 |
Illusion | 43.18 | 10.50 | 25 | 72956 | 737 | 31623626 |
Off label use | 43.09 | 10.50 | 553 | 72428 | 346721 | 31277642 |
Priapism | 42.76 | 10.50 | 53 | 72928 | 4567 | 31619796 |
Myocardial infarction | 42.76 | 10.50 | 127 | 72854 | 113327 | 31511036 |
Anger | 42.45 | 10.50 | 85 | 72896 | 11068 | 31613295 |
Pulmonary congestion | 40.22 | 10.50 | 91 | 72890 | 12892 | 31611471 |
Cough | 40.02 | 10.50 | 167 | 72814 | 134647 | 31489716 |
Platelet count decreased | 39.92 | 10.50 | 126 | 72855 | 110309 | 31514054 |
Major depression | 39.70 | 10.50 | 49 | 72932 | 4204 | 31620159 |
Illness anxiety disorder | 39.66 | 10.50 | 15 | 72966 | 160 | 31624203 |
Altered state of consciousness | 39.13 | 10.50 | 122 | 72859 | 20929 | 31603434 |
Pyrexia | 39.10 | 10.50 | 480 | 72501 | 303360 | 31321003 |
Atrial fibrillation | 38.93 | 10.50 | 133 | 72848 | 113650 | 31510713 |
Miosis | 38.39 | 10.50 | 70 | 72911 | 8500 | 31615863 |
Antipsychotic drug level above therapeutic | 37.78 | 10.50 | 27 | 72954 | 1150 | 31623213 |
Asthma | 37.62 | 10.50 | 26 | 72955 | 42585 | 31581778 |
Pneumonia | 37.60 | 10.50 | 545 | 72436 | 334767 | 31289596 |
Loss of libido | 37.06 | 10.50 | 36 | 72945 | 2359 | 31622004 |
Dystonia | 36.63 | 10.50 | 76 | 72905 | 10149 | 31614214 |
Infusion related reaction | 36.57 | 10.50 | 34 | 72947 | 48021 | 31576342 |
Vestibular disorder | 35.50 | 10.50 | 25 | 72956 | 1040 | 31623323 |
Rash | 35.10 | 10.50 | 296 | 72685 | 201190 | 31423173 |
Arthralgia | 34.92 | 10.50 | 205 | 72776 | 151219 | 31473144 |
General physical health deterioration | 34.88 | 10.50 | 407 | 72574 | 113028 | 31511335 |
Product prescribing error | 34.82 | 10.50 | 112 | 72869 | 19530 | 31604833 |
Renal failure | 34.63 | 10.50 | 156 | 72825 | 123174 | 31501189 |
Hyponatraemic coma | 34.05 | 10.50 | 9 | 72972 | 24 | 31624339 |
Irritability | 33.98 | 10.50 | 123 | 72858 | 22766 | 31601597 |
Hyponatraemia | 33.98 | 10.50 | 288 | 72693 | 73511 | 31550852 |
Drug hypersensitivity | 33.74 | 10.50 | 73 | 72908 | 72526 | 31551837 |
Tardive dyskinesia | 33.71 | 10.50 | 52 | 72929 | 5507 | 31618856 |
Cardiac failure congestive | 33.54 | 10.50 | 84 | 72897 | 79303 | 31545060 |
Disease progression | 33.54 | 10.50 | 102 | 72879 | 90362 | 31534001 |
Mental disorder | 33.30 | 10.50 | 88 | 72893 | 13746 | 31610617 |
Pleurothotonus | 32.84 | 10.50 | 24 | 72957 | 1059 | 31623304 |
Respiratory depression | 32.62 | 10.50 | 90 | 72891 | 14420 | 31609943 |
Drug ineffective | 32.15 | 10.50 | 681 | 72300 | 394892 | 31229471 |
Accidental death | 31.85 | 10.50 | 32 | 72949 | 2185 | 31622178 |
Aptyalism | 31.82 | 10.50 | 15 | 72966 | 286 | 31624077 |
Respiratory arrest | 31.57 | 10.50 | 132 | 72849 | 26125 | 31598238 |
Substance abuse | 31.47 | 10.50 | 58 | 72923 | 7100 | 31617263 |
Rhabdomyolysis | 31.34 | 10.50 | 252 | 72729 | 63329 | 31561034 |
Urinary retention | 31.23 | 10.50 | 157 | 72824 | 33568 | 31590795 |
Blood creatine phosphokinase increased | 31.18 | 10.50 | 184 | 72797 | 41790 | 31582573 |
Decreased gait velocity | 30.92 | 10.50 | 12 | 72969 | 138 | 31624225 |
Injection site pain | 30.75 | 10.50 | 21 | 72960 | 34613 | 31589750 |
Pleural effusion | 30.33 | 10.50 | 81 | 72900 | 74839 | 31549524 |
Persecutory delusion | 30.27 | 10.50 | 32 | 72949 | 2320 | 31622043 |
Drug dependence | 29.93 | 10.50 | 117 | 72864 | 22462 | 31601901 |
Urogenital haemorrhage | 29.90 | 10.50 | 18 | 72963 | 571 | 31623792 |
Feelings of worthlessness | 29.83 | 10.50 | 14 | 72967 | 264 | 31624099 |
Neuropathy peripheral | 29.71 | 10.50 | 83 | 72898 | 75566 | 31548797 |
Cytomegalovirus infection | 29.52 | 10.50 | 10 | 72971 | 24697 | 31599666 |
Nasal discomfort | 29.35 | 10.50 | 26 | 72955 | 1514 | 31622849 |
Prostate cancer | 29.32 | 10.50 | 26 | 72955 | 37575 | 31586788 |
Catatonia | 29.14 | 10.50 | 45 | 72936 | 4769 | 31619594 |
Electrocardiogram abnormal | 29.10 | 10.50 | 60 | 72921 | 7976 | 31616387 |
Thrombocytopenia | 28.94 | 10.50 | 201 | 72780 | 142546 | 31481817 |
Herpes zoster | 28.94 | 10.50 | 19 | 72962 | 31974 | 31592389 |
Dysarthria | 28.91 | 10.50 | 148 | 72833 | 31869 | 31592494 |
Selective eating disorder | 28.79 | 10.50 | 27 | 72954 | 1693 | 31622670 |
Stomatitis | 28.73 | 10.50 | 29 | 72952 | 39409 | 31584954 |
Sudden cardiac death | 27.89 | 10.50 | 37 | 72944 | 3412 | 31620951 |
Platypnoea | 27.81 | 10.50 | 8 | 72973 | 32 | 31624331 |
Sepsis | 27.43 | 10.50 | 221 | 72760 | 151708 | 31472655 |
Alcohol use | 27.20 | 10.50 | 35 | 72946 | 3132 | 31621231 |
Asphyxia | 27.07 | 10.50 | 48 | 72933 | 5703 | 31618660 |
Cardiac failure | 27.05 | 10.50 | 104 | 72877 | 85849 | 31538514 |
Sarcopenia | 25.90 | 10.50 | 14 | 72967 | 360 | 31624003 |
Macrophages increased | 25.78 | 10.50 | 11 | 72970 | 164 | 31624199 |
Patient elopement | 25.63 | 10.50 | 7 | 72974 | 22 | 31624341 |
Pressure of speech | 25.52 | 10.50 | 15 | 72966 | 455 | 31623908 |
Erythema | 25.49 | 10.50 | 97 | 72884 | 80308 | 31544055 |
Hyperhidrosis | 25.43 | 10.50 | 252 | 72729 | 67141 | 31557222 |
Hallucinations, mixed | 25.37 | 10.50 | 30 | 72951 | 2462 | 31621901 |
Feeling jittery | 25.28 | 10.50 | 37 | 72944 | 3740 | 31620623 |
Arthritis | 25.13 | 10.50 | 16 | 72965 | 27369 | 31596994 |
Prescription drug used without a prescription | 25.03 | 10.50 | 23 | 72958 | 1405 | 31622958 |
Oesophageal obstruction | 25.03 | 10.50 | 15 | 72966 | 472 | 31623891 |
Urticaria | 24.96 | 10.50 | 60 | 72921 | 57457 | 31566906 |
Depersonalisation/derealisation disorder | 24.92 | 10.50 | 16 | 72965 | 570 | 31623793 |
Hyperreflexia | 24.40 | 10.50 | 32 | 72949 | 2917 | 31621446 |
Benign gastrointestinal neoplasm | 24.33 | 10.50 | 10 | 72971 | 135 | 31624228 |
Mood altered | 24.20 | 10.50 | 57 | 72924 | 8289 | 31616074 |
Wrong product administered | 24.07 | 10.50 | 42 | 72939 | 4926 | 31619437 |
Myelosuppression | 24.05 | 10.50 | 3 | 72978 | 14917 | 31609446 |
Diarrhoea | 24.04 | 10.50 | 623 | 72358 | 351786 | 31272577 |
Congenital cerebrovascular anomaly | 23.89 | 10.50 | 6 | 72975 | 12 | 31624351 |
Postictal state | 23.73 | 10.50 | 17 | 72964 | 727 | 31623636 |
Dysphoria | 23.53 | 10.50 | 27 | 72954 | 2145 | 31622218 |
Product monitoring error | 23.14 | 10.50 | 33 | 72948 | 3257 | 31621106 |
Septic shock | 22.83 | 10.50 | 77 | 72904 | 66081 | 31558282 |
Bipolar disorder | 22.81 | 10.50 | 35 | 72946 | 3689 | 31620674 |
Urinary hesitation | 22.77 | 10.50 | 28 | 72953 | 2393 | 31621970 |
Seizure | 22.73 | 10.50 | 339 | 72642 | 99429 | 31524934 |
Depressive symptom | 22.44 | 10.50 | 26 | 72955 | 2088 | 31622275 |
Dementia with Lewy bodies | 22.42 | 10.50 | 16 | 72965 | 680 | 31623683 |
COVID-19 | 22.38 | 10.50 | 59 | 72922 | 54762 | 31569601 |
Joint swelling | 22.20 | 10.50 | 57 | 72924 | 53374 | 31570989 |
IVth nerve disorder | 22.18 | 10.50 | 6 | 72975 | 18 | 31624345 |
JC virus infection | 21.96 | 10.50 | 25 | 72956 | 1969 | 31622394 |
Thinking abnormal | 21.84 | 10.50 | 43 | 72938 | 5530 | 31618833 |
Intentional product use issue | 21.79 | 10.50 | 51 | 72930 | 49296 | 31575067 |
Suspected suicide | 21.59 | 10.50 | 36 | 72945 | 4071 | 31620292 |
Cold sweat | 21.58 | 10.50 | 58 | 72923 | 9151 | 31615212 |
Sinusitis | 21.44 | 10.50 | 32 | 72949 | 36664 | 31587699 |
Acute kidney injury | 21.09 | 10.50 | 487 | 72494 | 279227 | 31345136 |
Myelodysplastic syndrome | 20.98 | 10.50 | 9 | 72972 | 19242 | 31605121 |
Cogwheel rigidity | 20.98 | 10.50 | 20 | 72961 | 1280 | 31623083 |
Psoriasis | 20.86 | 10.50 | 48 | 72933 | 46671 | 31577692 |
Activation syndrome | 20.69 | 10.50 | 8 | 72973 | 91 | 31624272 |
Nervousness | 20.66 | 10.50 | 67 | 72914 | 11733 | 31612630 |
Dry skin | 20.62 | 10.50 | 17 | 72964 | 25464 | 31598899 |
Inappropriate schedule of product administration | 20.52 | 10.50 | 55 | 72926 | 50768 | 31573595 |
Circulatory collapse | 20.50 | 10.50 | 95 | 72886 | 19649 | 31604714 |
Slow speech | 20.50 | 10.50 | 18 | 72963 | 1036 | 31623327 |
Antipsychotic drug level increased | 20.48 | 10.50 | 32 | 72949 | 3426 | 31620937 |
Homicide | 20.33 | 10.50 | 17 | 72964 | 915 | 31623448 |
Postoperative respiratory failure | 20.31 | 10.50 | 8 | 72973 | 96 | 31624267 |
Congenital hyperinsulinaemic hypoglycaemia | 20.30 | 10.50 | 4 | 72977 | 0 | 31624363 |
Dysgraphia | 20.13 | 10.50 | 25 | 72956 | 2158 | 31622205 |
Upper respiratory tract infection | 19.91 | 10.50 | 23 | 72958 | 29399 | 31594964 |
Hypertonia | 19.82 | 10.50 | 34 | 72947 | 3934 | 31620429 |
Acute myocardial infarction | 19.77 | 10.50 | 56 | 72925 | 50767 | 31573596 |
Perforated ulcer | 19.71 | 10.50 | 9 | 72972 | 159 | 31624204 |
Parkinsonian gait | 19.67 | 10.50 | 13 | 72968 | 487 | 31623876 |
Tubulointerstitial nephritis | 19.61 | 10.50 | 9 | 72972 | 18487 | 31605876 |
Peripheral swelling | 19.54 | 10.50 | 85 | 72896 | 67780 | 31556583 |
Alcoholism | 19.50 | 10.50 | 31 | 72950 | 3368 | 31620995 |
Feeling guilty | 19.44 | 10.50 | 11 | 72970 | 310 | 31624053 |
Mental impairment | 19.36 | 10.50 | 57 | 72924 | 9475 | 31614888 |
White blood cell count decreased | 19.24 | 10.50 | 120 | 72861 | 87278 | 31537085 |
Malignant neoplasm progression | 19.24 | 10.50 | 105 | 72876 | 78893 | 31545470 |
Helplessness | 19.09 | 10.50 | 7 | 72974 | 68 | 31624295 |
Acute psychosis | 19.06 | 10.50 | 22 | 72959 | 1759 | 31622604 |
Verbal abuse | 19.02 | 10.50 | 9 | 72972 | 173 | 31624190 |
Tumour lysis syndrome | 18.78 | 10.50 | 6 | 72975 | 15379 | 31608984 |
Intentional device misuse | 18.75 | 10.50 | 9 | 72972 | 179 | 31624184 |
Hanging | 18.71 | 10.50 | 8 | 72973 | 120 | 31624243 |
Bezoar | 18.65 | 10.50 | 16 | 72965 | 892 | 31623471 |
Neutropenia | 18.65 | 10.50 | 220 | 72761 | 140144 | 31484219 |
Respiratory disorder neonatal | 18.64 | 10.50 | 20 | 72961 | 1475 | 31622888 |
Haemoglobin decreased | 18.49 | 10.50 | 168 | 72813 | 112507 | 31511856 |
Hyperkinesia | 18.47 | 10.50 | 21 | 72960 | 1652 | 31622711 |
Hypersomnia | 18.45 | 10.50 | 62 | 72919 | 11057 | 31613306 |
Acute myeloid leukaemia | 18.41 | 10.50 | 10 | 72971 | 18662 | 31605701 |
Multiple organ dysfunction syndrome | 18.10 | 10.50 | 88 | 72893 | 68115 | 31556248 |
Obsessive-compulsive disorder | 18.04 | 10.50 | 37 | 72944 | 4900 | 31619463 |
Back pain | 18.01 | 10.50 | 163 | 72818 | 109250 | 31515113 |
Arachnoid cyst | 17.92 | 10.50 | 9 | 72972 | 198 | 31624165 |
Tracheal pain | 17.84 | 10.50 | 6 | 72975 | 44 | 31624319 |
Nephrolithiasis | 17.83 | 10.50 | 22 | 72959 | 27317 | 31597046 |
Derealisation | 17.82 | 10.50 | 13 | 72968 | 572 | 31623791 |
Hypervigilance | 17.80 | 10.50 | 8 | 72973 | 136 | 31624227 |
Eosinophilic myocarditis | 17.79 | 10.50 | 12 | 72969 | 465 | 31623898 |
Product prescribing issue | 17.61 | 10.50 | 20 | 72961 | 1571 | 31622792 |
Delusion of grandeur | 17.58 | 10.50 | 14 | 72967 | 703 | 31623660 |
Drug withdrawal syndrome neonatal | 17.55 | 10.50 | 30 | 72951 | 3462 | 31620901 |
Fear of weight gain | 17.54 | 10.50 | 4 | 72977 | 4 | 31624359 |
Gout | 17.54 | 10.50 | 10 | 72971 | 18164 | 31606199 |
Hangover | 17.53 | 10.50 | 16 | 72965 | 969 | 31623394 |
Ejaculation disorder | 17.46 | 10.50 | 16 | 72965 | 974 | 31623389 |
Epilepsy | 17.44 | 10.50 | 95 | 72886 | 20946 | 31603417 |
Implant site extravasation | 17.41 | 10.50 | 11 | 72970 | 381 | 31623982 |
Blood creatinine increased | 17.27 | 10.50 | 127 | 72854 | 88951 | 31535412 |
Stoma site infection | 17.23 | 10.50 | 14 | 72967 | 724 | 31623639 |
Arthropathy | 17.16 | 10.50 | 18 | 72963 | 24033 | 31600330 |
Dementia | 17.15 | 10.50 | 65 | 72916 | 12295 | 31612068 |
Temperature regulation disorder | 17.11 | 10.50 | 13 | 72968 | 609 | 31623754 |
Osteonecrosis of jaw | 17.04 | 10.50 | 9 | 72972 | 17062 | 31607301 |
Electrocardiogram QRS complex prolonged | 17.02 | 10.50 | 33 | 72948 | 4196 | 31620167 |
Incoherent | 16.94 | 10.50 | 33 | 72948 | 4211 | 31620152 |
Intentional product misuse | 16.87 | 10.50 | 147 | 72834 | 37804 | 31586559 |
Amnestic disorder | 16.81 | 10.50 | 9 | 72972 | 227 | 31624136 |
Alcohol interaction | 16.78 | 10.50 | 26 | 72955 | 2763 | 31621600 |
Ejaculation failure | 16.69 | 10.50 | 14 | 72967 | 757 | 31623606 |
Mastication disorder | 16.64 | 10.50 | 17 | 72964 | 1184 | 31623179 |
Loose associations | 16.57 | 10.50 | 6 | 72975 | 56 | 31624307 |
Eosinophilic pleural effusion | 16.53 | 10.50 | 9 | 72972 | 235 | 31624128 |
Ataxia | 16.51 | 10.50 | 66 | 72915 | 12797 | 31611566 |
Sexual dysfunction | 16.49 | 10.50 | 40 | 72941 | 5928 | 31618435 |
Respiratory tract infection | 16.47 | 10.50 | 10 | 72971 | 17551 | 31606812 |
Posture abnormal | 16.47 | 10.50 | 22 | 72959 | 2042 | 31622321 |
Oesophageal haemorrhage | 16.38 | 10.50 | 17 | 72964 | 1206 | 31623157 |
Urine sodium decreased | 16.23 | 10.50 | 8 | 72973 | 169 | 31624194 |
Metabolic syndrome | 16.21 | 10.50 | 19 | 72962 | 1544 | 31622819 |
Hyperbilirubinaemia | 16.18 | 10.50 | 8 | 72973 | 15742 | 31608621 |
Plasma cell myeloma | 16.15 | 10.50 | 71 | 72910 | 56460 | 31567903 |
Ascites | 16.09 | 10.50 | 45 | 72936 | 40968 | 31583395 |
Speech disorder | 16.02 | 10.50 | 103 | 72878 | 24098 | 31600265 |
Gait disturbance | 15.99 | 10.50 | 259 | 72722 | 77236 | 31547127 |
Psychomotor skills impaired | 15.89 | 10.50 | 27 | 72954 | 3100 | 31621263 |
Rapid eye movements sleep abnormal | 15.89 | 10.50 | 8 | 72973 | 177 | 31624186 |
Bladder cancer | 15.87 | 10.50 | 7 | 72974 | 14718 | 31609645 |
Abdominal discomfort | 15.83 | 10.50 | 63 | 72918 | 51504 | 31572859 |
Amnesia | 15.73 | 10.50 | 100 | 72881 | 23302 | 31601061 |
Abnormal weight gain | 15.72 | 10.50 | 15 | 72966 | 961 | 31623402 |
Tricuspid valve sclerosis | 15.72 | 10.50 | 5 | 72976 | 30 | 31624333 |
Palmar-plantar erythrodysaesthesia syndrome | 15.70 | 10.50 | 8 | 72973 | 15475 | 31608888 |
Mucosal inflammation | 15.67 | 10.50 | 35 | 72946 | 34392 | 31589971 |
JC virus CSF test positive | 15.63 | 10.50 | 7 | 72974 | 118 | 31624245 |
Sinus bradycardia | 15.50 | 10.50 | 62 | 72919 | 12025 | 31612338 |
Infant irritability | 15.45 | 10.50 | 5 | 72976 | 32 | 31624331 |
Hyporesponsive to stimuli | 15.44 | 10.50 | 15 | 72966 | 983 | 31623380 |
Stupor | 15.44 | 10.50 | 25 | 72956 | 2759 | 31621604 |
Drug dispensed to wrong patient | 15.40 | 10.50 | 11 | 72970 | 468 | 31623895 |
Dissociation | 15.39 | 10.50 | 17 | 72964 | 1295 | 31623068 |
Sleep deficit | 15.38 | 10.50 | 11 | 72970 | 469 | 31623894 |
Loss of proprioception | 15.36 | 10.50 | 10 | 72971 | 365 | 31623998 |
Potentiating drug interaction | 15.33 | 10.50 | 33 | 72948 | 4520 | 31619843 |
Small for dates baby | 15.30 | 10.50 | 29 | 72952 | 3626 | 31620737 |
Neonatal respiratory distress syndrome | 15.25 | 10.50 | 30 | 72951 | 3855 | 31620508 |
Skin lesion inflammation | 15.23 | 10.50 | 3 | 72978 | 0 | 31624363 |
Blood ethanol increased | 15.16 | 10.50 | 11 | 72970 | 480 | 31623883 |
Neonatal hyponatraemia | 15.16 | 10.50 | 6 | 72975 | 73 | 31624290 |
Balance disorder | 15.13 | 10.50 | 142 | 72839 | 37280 | 31587083 |
Neutrophil count increased | 15.10 | 10.50 | 74 | 72907 | 15657 | 31608706 |
Oedema peripheral | 15.03 | 10.50 | 171 | 72810 | 109668 | 31514695 |
Brain oedema | 15.02 | 10.50 | 64 | 72917 | 12768 | 31611595 |
Chest pain | 14.88 | 10.50 | 185 | 72796 | 116772 | 31507591 |
Basal cell carcinoma | 14.87 | 10.50 | 12 | 72969 | 18167 | 31606196 |
Appendicitis | 14.85 | 10.50 | 4 | 72977 | 11461 | 31612902 |
Self esteem decreased | 14.65 | 10.50 | 11 | 72970 | 506 | 31623857 |
Respiratory rate decreased | 14.64 | 10.50 | 21 | 72960 | 2084 | 31622279 |
Mumps | 14.60 | 10.50 | 6 | 72975 | 81 | 31624282 |
Rapid eye movement sleep behaviour disorder | 14.59 | 10.50 | 7 | 72974 | 139 | 31624224 |
Paradoxical drug reaction | 14.58 | 10.50 | 26 | 72955 | 3103 | 31621260 |
Pancytopenia | 14.40 | 10.50 | 130 | 72851 | 87186 | 31537177 |
Suspiciousness | 14.34 | 10.50 | 9 | 72972 | 308 | 31624055 |
Fear | 14.30 | 10.50 | 53 | 72928 | 9921 | 31614442 |
Feeling abnormal | 14.29 | 10.50 | 197 | 72784 | 56805 | 31567558 |
Sensory disturbance | 14.28 | 10.50 | 37 | 72944 | 5710 | 31618653 |
Abulia | 14.26 | 10.50 | 11 | 72970 | 527 | 31623836 |
Autoscopy | 14.23 | 10.50 | 7 | 72974 | 147 | 31624216 |
Sinus tachycardia | 14.12 | 10.50 | 73 | 72908 | 15776 | 31608587 |
Splenomegaly | 14.10 | 10.50 | 7 | 72974 | 13742 | 31610621 |
Product use issue | 14.06 | 10.50 | 75 | 72906 | 56684 | 31567679 |
Housebound | 14.00 | 10.50 | 8 | 72973 | 230 | 31624133 |
Abnormal dreams | 13.95 | 10.50 | 42 | 72939 | 7066 | 31617297 |
Rash erythematous | 13.94 | 10.50 | 19 | 72962 | 22608 | 31601755 |
Xanthoma | 13.91 | 10.50 | 6 | 72975 | 92 | 31624271 |
Bronchopulmonary aspergillosis | 13.89 | 10.50 | 7 | 72974 | 13627 | 31610736 |
Anaemia | 13.84 | 10.50 | 380 | 72601 | 213142 | 31411221 |
Lung disorder | 13.78 | 10.50 | 34 | 72947 | 32278 | 31592085 |
Failure to thrive | 13.75 | 10.50 | 45 | 72936 | 7917 | 31616446 |
Nasal congestion | 13.72 | 10.50 | 16 | 72965 | 20365 | 31603998 |
COVID-19 pneumonia | 13.66 | 10.50 | 6 | 72975 | 12649 | 31611714 |
Spinal cord injury thoracic | 13.62 | 10.50 | 6 | 72975 | 97 | 31624266 |
Limited symptom panic attack | 13.60 | 10.50 | 5 | 72976 | 49 | 31624314 |
Non-alcoholic steatohepatitis | 13.52 | 10.50 | 13 | 72968 | 841 | 31623522 |
Renal disorder | 13.44 | 10.50 | 21 | 72960 | 23624 | 31600739 |
Drug reaction with eosinophilia and systemic symptoms | 13.27 | 10.50 | 31 | 72950 | 29987 | 31594376 |
Accidental poisoning | 13.26 | 10.50 | 12 | 72969 | 719 | 31623644 |
Locked-in syndrome | 13.23 | 10.50 | 8 | 72973 | 256 | 31624107 |
Sepsis neonatal | 13.09 | 10.50 | 8 | 72973 | 261 | 31624102 |
Alcohol poisoning | 13.08 | 10.50 | 25 | 72956 | 3146 | 31621217 |
Behaviour disorder | 12.94 | 10.50 | 30 | 72951 | 4317 | 31620046 |
Mitral valve sclerosis | 12.94 | 10.50 | 6 | 72975 | 110 | 31624253 |
Blood pressure increased | 12.94 | 10.50 | 119 | 72862 | 79514 | 31544849 |
Bacteraemia | 12.80 | 10.50 | 13 | 72968 | 17621 | 31606742 |
Insulin resistance | 12.80 | 10.50 | 11 | 72970 | 615 | 31623748 |
Fungal infection | 12.68 | 10.50 | 9 | 72972 | 14542 | 31609821 |
Pneumocystis jirovecii pneumonia | 12.64 | 10.50 | 14 | 72967 | 18237 | 31606126 |
Gastrointestinal disorder | 12.51 | 10.50 | 33 | 72948 | 30627 | 31593736 |
Pelvic fracture | 12.48 | 10.50 | 21 | 72960 | 2392 | 31621971 |
Cytokine release syndrome | 12.39 | 10.50 | 12 | 72969 | 16630 | 31607733 |
Renal impairment | 12.38 | 10.50 | 133 | 72848 | 86216 | 31538147 |
Consciousness fluctuating | 12.36 | 10.50 | 14 | 72967 | 1097 | 31623266 |
Fluid retention | 12.31 | 10.50 | 24 | 72957 | 24778 | 31599585 |
Polypectomy | 12.29 | 10.50 | 10 | 72971 | 518 | 31623845 |
Stoma site discharge | 12.28 | 10.50 | 13 | 72968 | 944 | 31623419 |
Acute pulmonary oedema | 12.22 | 10.50 | 40 | 72941 | 7036 | 31617327 |
Light chain disease | 12.16 | 10.50 | 6 | 72975 | 127 | 31624236 |
Initial insomnia | 12.08 | 10.50 | 23 | 72958 | 2886 | 31621477 |
Bronchitis | 12.07 | 10.50 | 47 | 72934 | 38670 | 31585693 |
Inferior vena caval occlusion | 12.05 | 10.50 | 4 | 72977 | 28 | 31624335 |
Angina pectoris | 12.02 | 10.50 | 32 | 72949 | 29609 | 31594754 |
Hepatic failure | 12.02 | 10.50 | 37 | 72944 | 32665 | 31591698 |
Respiratory tract haemorrhage | 11.95 | 10.50 | 14 | 72967 | 1137 | 31623226 |
Hepatic steatosis | 11.93 | 10.50 | 71 | 72910 | 16168 | 31608195 |
Electric shock | 11.87 | 10.50 | 6 | 72975 | 134 | 31624229 |
Rash maculo-papular | 11.82 | 10.50 | 26 | 72955 | 25693 | 31598670 |
Infection | 11.82 | 10.50 | 126 | 72855 | 81805 | 31542558 |
Hyperthermia | 11.79 | 10.50 | 50 | 72931 | 9954 | 31614409 |
Dyspnoea | 11.78 | 10.50 | 659 | 72322 | 342820 | 31281543 |
Cerebellar ataxia | 11.76 | 10.50 | 13 | 72968 | 991 | 31623372 |
Pneumonitis | 11.75 | 10.50 | 34 | 72947 | 30618 | 31593745 |
Body temperature abnormal | 11.74 | 10.50 | 10 | 72971 | 552 | 31623811 |
Staphylococcal infection | 11.73 | 10.50 | 34 | 72947 | 30598 | 31593765 |
Dysaesthesia | 11.71 | 10.50 | 19 | 72962 | 2100 | 31622263 |
Bladder dilatation | 11.67 | 10.50 | 15 | 72966 | 1341 | 31623022 |
Erectile dysfunction | 11.60 | 10.50 | 80 | 72901 | 19155 | 31605208 |
Radial nerve injury | 11.48 | 10.50 | 4 | 72977 | 33 | 31624330 |
Coma scale abnormal | 11.42 | 10.50 | 26 | 72955 | 3697 | 31620666 |
Psychotic symptom | 11.40 | 10.50 | 16 | 72965 | 1556 | 31622807 |
Pseudomonas infection | 11.40 | 10.50 | 6 | 72975 | 11395 | 31612968 |
Hypertension | 11.39 | 10.50 | 217 | 72764 | 127883 | 31496480 |
Agitated depression | 11.38 | 10.50 | 7 | 72974 | 231 | 31624132 |
Nephropathy toxic | 11.31 | 10.50 | 6 | 72975 | 11347 | 31613016 |
Blood pressure fluctuation | 11.28 | 10.50 | 22 | 72959 | 22714 | 31601649 |
Formication | 11.28 | 10.50 | 16 | 72965 | 1571 | 31622792 |
Panic disorder | 11.28 | 10.50 | 14 | 72967 | 1208 | 31623155 |
Shock | 11.16 | 10.50 | 22 | 72959 | 22623 | 31601740 |
Hypotonia | 11.16 | 10.50 | 39 | 72942 | 7094 | 31617269 |
Tension | 11.14 | 10.50 | 18 | 72963 | 1983 | 31622380 |
Gallbladder enlargement | 11.10 | 10.50 | 13 | 72968 | 1056 | 31623307 |
Hypersensitivity | 11.03 | 10.50 | 79 | 72902 | 55664 | 31568699 |
Pneumonia bacterial | 10.93 | 10.50 | 5 | 72976 | 10291 | 31614072 |
Serum serotonin increased | 10.92 | 10.50 | 5 | 72976 | 89 | 31624274 |
Respiratory failure | 10.92 | 10.50 | 166 | 72815 | 101283 | 31523080 |
Skin cancer | 10.86 | 10.50 | 4 | 72977 | 9381 | 31614982 |
Kidney congestion | 10.84 | 10.50 | 7 | 72974 | 252 | 31624111 |
Mutism | 10.80 | 10.50 | 11 | 72970 | 763 | 31623600 |
Influenza | 10.74 | 10.50 | 59 | 72922 | 44266 | 31580097 |
Stoma site induration | 10.72 | 10.50 | 4 | 72977 | 41 | 31624322 |
JC polyomavirus test positive | 10.72 | 10.50 | 10 | 72971 | 623 | 31623740 |
Drug abuser | 10.71 | 10.50 | 26 | 72955 | 3854 | 31620509 |
Feeling of despair | 10.70 | 10.50 | 12 | 72969 | 930 | 31623433 |
Frequent bowel movements | 10.68 | 10.50 | 5 | 72976 | 10154 | 31614209 |
Hypertrophic scar | 10.63 | 10.50 | 3 | 72978 | 11 | 31624352 |
Jealous delusion | 10.62 | 10.50 | 7 | 72974 | 261 | 31624102 |
Neoplasm progression | 10.60 | 10.50 | 19 | 72962 | 20253 | 31604110 |
Thrombotic stroke | 10.60 | 10.50 | 7 | 72974 | 262 | 31624101 |
Rebound effect | 10.59 | 10.50 | 20 | 72961 | 2493 | 31621870 |
Respiratory acidosis | 10.56 | 10.50 | 29 | 72952 | 4633 | 31619730 |
Cellulitis | 10.52 | 10.50 | 66 | 72915 | 47952 | 31576411 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Toxicity to various agents | 968.32 | 9.89 | 2370 | 150305 | 379802 | 70395967 |
Intentional overdose | 833.51 | 9.89 | 1043 | 151632 | 97392 | 70678377 |
Serotonin syndrome | 778.01 | 9.89 | 678 | 151997 | 41436 | 70734333 |
Suicide attempt | 756.81 | 9.89 | 894 | 151781 | 78616 | 70697153 |
Drug abuse | 678.63 | 9.89 | 1171 | 151504 | 146085 | 70629684 |
Completed suicide | 676.09 | 9.89 | 1502 | 151173 | 225633 | 70550136 |
Intentional self-injury | 655.07 | 9.89 | 544 | 152131 | 31106 | 70744663 |
Suicidal ideation | 588.16 | 9.89 | 737 | 151938 | 68859 | 70706910 |
Sopor | 548.65 | 9.89 | 489 | 152186 | 30778 | 70744991 |
Overdose | 467.37 | 9.89 | 1089 | 151586 | 168656 | 70607113 |
Somnolence | 451.65 | 9.89 | 1247 | 151428 | 214359 | 70561410 |
Agitation | 451.53 | 9.89 | 759 | 151916 | 92616 | 70683153 |
Rheumatoid arthritis | 399.01 | 9.89 | 73 | 152602 | 291732 | 70484037 |
Drug interaction | 396.74 | 9.89 | 1748 | 150927 | 379693 | 70396076 |
Electrocardiogram QT prolonged | 376.29 | 9.89 | 658 | 152017 | 82859 | 70692910 |
Confusional state | 346.05 | 9.89 | 1368 | 151307 | 283030 | 70492739 |
Hyponatraemia | 290.59 | 9.89 | 880 | 151795 | 159207 | 70616562 |
Coma | 288.08 | 9.89 | 621 | 152054 | 91223 | 70684546 |
Depression | 285.02 | 9.89 | 1009 | 151666 | 197965 | 70577804 |
Restlessness | 281.67 | 9.89 | 398 | 152277 | 41730 | 70734039 |
Anxiety | 254.31 | 9.89 | 1043 | 151632 | 219287 | 70556482 |
Fall | 245.23 | 9.89 | 1715 | 150960 | 442381 | 70333388 |
Neuroleptic malignant syndrome | 244.82 | 9.89 | 291 | 152384 | 25716 | 70750053 |
Disorientation | 243.66 | 9.89 | 443 | 152232 | 57480 | 70718289 |
Tremor | 240.92 | 9.89 | 810 | 151865 | 154814 | 70620955 |
Restless legs syndrome | 231.83 | 9.89 | 240 | 152435 | 18188 | 70757581 |
Infusion related reaction | 223.97 | 9.89 | 73 | 152602 | 197461 | 70578308 |
Synovitis | 216.70 | 9.89 | 16 | 152659 | 129212 | 70646557 |
Joint swelling | 209.90 | 9.89 | 144 | 152531 | 253067 | 70522702 |
Inappropriate antidiuretic hormone secretion | 206.93 | 9.89 | 253 | 152422 | 23023 | 70752746 |
Depressed level of consciousness | 206.30 | 9.89 | 529 | 152146 | 86902 | 70688867 |
Aggression | 201.82 | 9.89 | 369 | 152306 | 48077 | 70727692 |
Akathisia | 201.31 | 9.89 | 185 | 152490 | 12108 | 70763661 |
Delirium | 201.00 | 9.89 | 475 | 152200 | 74139 | 70701630 |
Disturbance in attention | 197.05 | 9.89 | 341 | 152334 | 42553 | 70733216 |
Nightmare | 194.01 | 9.89 | 239 | 152436 | 21917 | 70753852 |
Muscle rigidity | 191.11 | 9.89 | 218 | 152457 | 18432 | 70757337 |
Depressed mood | 187.91 | 9.89 | 338 | 152337 | 43482 | 70732287 |
Drug withdrawal syndrome | 184.01 | 9.89 | 285 | 152390 | 32430 | 70743339 |
Arthropathy | 183.74 | 9.89 | 48 | 152627 | 150009 | 70625760 |
Extrapyramidal disorder | 177.14 | 9.89 | 221 | 152454 | 20529 | 70755240 |
Rash | 174.18 | 9.89 | 543 | 152132 | 510019 | 70265750 |
Nasopharyngitis | 170.40 | 9.89 | 137 | 152538 | 222069 | 70553700 |
Hallucination, visual | 165.59 | 9.89 | 256 | 152419 | 29081 | 70746688 |
Tachycardia | 164.55 | 9.89 | 727 | 151948 | 157819 | 70617950 |
Systemic lupus erythematosus | 161.59 | 9.89 | 16 | 152659 | 101886 | 70673883 |
Dyskinesia | 158.77 | 9.89 | 303 | 152372 | 40771 | 70734998 |
Mania | 156.44 | 9.89 | 189 | 152486 | 16985 | 70758784 |
Sinusitis | 155.77 | 9.89 | 85 | 152590 | 169110 | 70606659 |
Withdrawal syndrome | 152.89 | 9.89 | 226 | 152449 | 24678 | 70751091 |
Arthralgia | 152.84 | 9.89 | 563 | 152112 | 502827 | 70272942 |
Psychotic disorder | 150.54 | 9.89 | 282 | 152393 | 37419 | 70738350 |
Depersonalisation/derealisation disorder | 147.25 | 9.89 | 73 | 152602 | 1675 | 70774094 |
Pemphigus | 145.98 | 9.89 | 8 | 152667 | 83028 | 70692741 |
Accidental overdose | 145.62 | 9.89 | 267 | 152408 | 34854 | 70740915 |
Dissociation | 143.77 | 9.89 | 90 | 152585 | 3286 | 70772483 |
Swelling | 137.46 | 9.89 | 122 | 152553 | 188417 | 70587352 |
Drug hypersensitivity | 135.04 | 9.89 | 223 | 152452 | 262236 | 70513533 |
Parkinsonism | 133.67 | 9.89 | 165 | 152510 | 15160 | 70760609 |
Glossodynia | 131.00 | 9.89 | 16 | 152659 | 86471 | 70689298 |
Sedation | 127.45 | 9.89 | 299 | 152376 | 46432 | 70729337 |
Urinary retention | 126.15 | 9.89 | 320 | 152355 | 52200 | 70723569 |
Hallucination | 126.00 | 9.89 | 406 | 152269 | 75854 | 70699915 |
Peripheral swelling | 125.45 | 9.89 | 197 | 152478 | 236366 | 70539403 |
Hallucination, auditory | 125.21 | 9.89 | 175 | 152500 | 18153 | 70757616 |
Alopecia | 124.74 | 9.89 | 146 | 152529 | 198344 | 70577425 |
Drug ineffective | 121.16 | 9.89 | 1368 | 151307 | 938384 | 69837385 |
Therapeutic product effect decreased | 120.21 | 9.89 | 80 | 152595 | 142938 | 70632831 |
Poisoning | 120.17 | 9.89 | 192 | 152483 | 22430 | 70753339 |
Derealisation | 120.14 | 9.89 | 61 | 152614 | 1475 | 70774294 |
Cogwheel rigidity | 118.60 | 9.89 | 76 | 152599 | 2892 | 70772877 |
Abdominal discomfort | 118.40 | 9.89 | 174 | 152501 | 214484 | 70561285 |
Treatment failure | 118.00 | 9.89 | 83 | 152592 | 144059 | 70631710 |
General physical health deterioration | 116.93 | 9.89 | 889 | 151786 | 235142 | 70540627 |
Myoclonus | 115.17 | 9.89 | 205 | 152470 | 26150 | 70749619 |
Dystonia | 112.66 | 9.89 | 173 | 152502 | 19533 | 70756236 |
Loss of consciousness | 112.04 | 9.89 | 644 | 152031 | 155072 | 70620697 |
Pain | 110.81 | 9.89 | 846 | 151829 | 627970 | 70147799 |
Hyperhidrosis | 110.73 | 9.89 | 568 | 152107 | 131018 | 70644751 |
Dysarthria | 109.59 | 9.89 | 339 | 152336 | 61974 | 70713795 |
Contraindicated product administered | 109.54 | 9.89 | 78 | 152597 | 134534 | 70641235 |
Intrusive thoughts | 108.99 | 9.89 | 39 | 152636 | 378 | 70775391 |
Mydriasis | 108.51 | 9.89 | 153 | 152522 | 16000 | 70759769 |
Drug intolerance | 106.80 | 9.89 | 202 | 152473 | 225485 | 70550284 |
Progressive multifocal leukoencephalopathy | 104.71 | 9.89 | 165 | 152510 | 19049 | 70756720 |
Gastric pH decreased | 104.23 | 9.89 | 45 | 152630 | 743 | 70775026 |
Hypersensitivity | 104.16 | 9.89 | 211 | 152464 | 229601 | 70546168 |
Helicobacter infection | 102.25 | 9.89 | 4 | 152671 | 55652 | 70720117 |
Feeling of despair | 101.29 | 9.89 | 66 | 152609 | 2585 | 70773184 |
Mood swings | 96.86 | 9.89 | 155 | 152520 | 18131 | 70757638 |
Pericarditis | 96.48 | 9.89 | 31 | 152644 | 84674 | 70691095 |
Psychomotor hyperactivity | 96.09 | 9.89 | 141 | 152534 | 15292 | 70760477 |
Urticaria | 96.06 | 9.89 | 126 | 152549 | 162923 | 70612846 |
Injection site pain | 94.59 | 9.89 | 69 | 152606 | 117550 | 70658219 |
Major depression | 94.30 | 9.89 | 104 | 152571 | 8470 | 70767299 |
Seizure | 93.02 | 9.89 | 679 | 151996 | 177283 | 70598486 |
Cough | 92.73 | 9.89 | 373 | 152302 | 325004 | 70450765 |
Pleurothotonus | 88.19 | 9.89 | 58 | 152617 | 2308 | 70773461 |
Abnormal behaviour | 88.09 | 9.89 | 216 | 152459 | 34493 | 70741276 |
Febrile neutropenia | 87.22 | 9.89 | 194 | 152481 | 204124 | 70571645 |
Poisoning deliberate | 86.81 | 9.89 | 142 | 152533 | 16918 | 70758851 |
Tardive dyskinesia | 85.14 | 9.89 | 106 | 152569 | 9823 | 70765946 |
Paranoia | 84.08 | 9.89 | 141 | 152534 | 17147 | 70758622 |
Altered state of consciousness | 84.05 | 9.89 | 232 | 152443 | 39790 | 70735979 |
Pneumonia aspiration | 84.01 | 9.89 | 310 | 152365 | 61979 | 70713790 |
Arthritis | 80.72 | 9.89 | 56 | 152619 | 97924 | 70677845 |
Hypertonia | 80.59 | 9.89 | 84 | 152591 | 6414 | 70769355 |
Pruritus | 80.16 | 9.89 | 427 | 152248 | 345133 | 70430636 |
Drug dependence | 80.03 | 9.89 | 218 | 152457 | 37103 | 70738666 |
Feeling jittery | 80.02 | 9.89 | 111 | 152564 | 11432 | 70764337 |
Delusion | 79.82 | 9.89 | 146 | 152529 | 19019 | 70756750 |
Product use issue | 79.15 | 9.89 | 168 | 152507 | 179769 | 70596000 |
Sleep disorder | 79.03 | 9.89 | 329 | 152346 | 69543 | 70706226 |
Bradyphrenia | 78.67 | 9.89 | 102 | 152573 | 9844 | 70765925 |
Folliculitis | 78.40 | 9.89 | 3 | 152672 | 42567 | 70733202 |
Impaired healing | 78.25 | 9.89 | 31 | 152644 | 74343 | 70701426 |
Anger | 77.69 | 9.89 | 131 | 152544 | 16001 | 70759768 |
Logorrhoea | 77.45 | 9.89 | 67 | 152608 | 4047 | 70771722 |
Psoriatic arthropathy | 76.84 | 9.89 | 22 | 152653 | 64749 | 70711020 |
Product prescribing error | 76.13 | 9.89 | 220 | 152455 | 38732 | 70737037 |
Depressive symptom | 75.32 | 9.89 | 73 | 152602 | 5108 | 70770661 |
On and off phenomenon | 75.12 | 9.89 | 56 | 152619 | 2730 | 70773039 |
Off label use | 74.45 | 9.89 | 1139 | 151536 | 741921 | 70033848 |
Duodenal ulcer perforation | 73.72 | 9.89 | 11 | 152664 | 51101 | 70724668 |
Rhabdomyolysis | 72.77 | 9.89 | 402 | 152273 | 95358 | 70680411 |
Asphyxia | 72.51 | 9.89 | 100 | 152575 | 10242 | 70765527 |
Insomnia | 71.94 | 9.89 | 751 | 151924 | 217055 | 70558714 |
Hallucinations, mixed | 71.41 | 9.89 | 78 | 152597 | 6284 | 70769485 |
Homicidal ideation | 70.55 | 9.89 | 58 | 152617 | 3265 | 70772504 |
Irritability | 70.04 | 9.89 | 211 | 152464 | 38014 | 70737755 |
Respiratory arrest | 69.06 | 9.89 | 264 | 152411 | 53669 | 70722100 |
Discomfort | 68.99 | 9.89 | 75 | 152600 | 105361 | 70670408 |
Speech disorder | 68.43 | 9.89 | 252 | 152423 | 50328 | 70725441 |
Panic attack | 67.50 | 9.89 | 148 | 152527 | 21971 | 70753798 |
Bradykinesia | 67.41 | 9.89 | 82 | 152593 | 7420 | 70768349 |
Systemic infection | 66.82 | 9.89 | 77 | 152598 | 6580 | 70769189 |
Asthma | 66.47 | 9.89 | 98 | 152577 | 120695 | 70655074 |
Irritable bowel syndrome | 64.67 | 9.89 | 15 | 152660 | 50835 | 70724934 |
Intentional product use issue | 64.63 | 9.89 | 99 | 152576 | 120043 | 70655726 |
Incontinence | 64.35 | 9.89 | 107 | 152568 | 12921 | 70762848 |
Miosis | 63.30 | 9.89 | 111 | 152564 | 13990 | 70761779 |
Wrong patient received product | 63.03 | 9.89 | 62 | 152613 | 4418 | 70771351 |
Hepatic enzyme increased | 62.23 | 9.89 | 155 | 152520 | 156835 | 70618934 |
Abnormal dreams | 61.90 | 9.89 | 94 | 152581 | 10509 | 70765260 |
Stomatitis | 61.65 | 9.89 | 114 | 152561 | 128397 | 70647372 |
Myocardial infarction | 61.60 | 9.89 | 178 | 152497 | 171467 | 70604302 |
Substance abuse | 61.42 | 9.89 | 90 | 152585 | 9747 | 70766022 |
Antidepressant drug level above therapeutic | 61.31 | 9.89 | 29 | 152646 | 598 | 70775171 |
Tachyphrenia | 61.23 | 9.89 | 43 | 152632 | 1908 | 70773861 |
Respiratory depression | 60.34 | 9.89 | 152 | 152523 | 24679 | 70751090 |
Loss of libido | 60.30 | 9.89 | 47 | 152628 | 2450 | 70773319 |
Infection | 59.13 | 9.89 | 243 | 152432 | 210542 | 70565227 |
Interstitial lung disease | 58.51 | 9.89 | 84 | 152591 | 104601 | 70671168 |
Drooling | 58.17 | 9.89 | 65 | 152610 | 5371 | 70770398 |
Illusion | 57.81 | 9.89 | 39 | 152636 | 1620 | 70774149 |
Injection site pruritus | 57.57 | 9.89 | 8 | 152667 | 39202 | 70736567 |
Injection site erythema | 57.05 | 9.89 | 44 | 152631 | 72880 | 70702889 |
Blister | 56.84 | 9.89 | 80 | 152595 | 100446 | 70675323 |
Nasal congestion | 56.16 | 9.89 | 36 | 152639 | 65636 | 70710133 |
Feeling of body temperature change | 55.81 | 9.89 | 61 | 152614 | 4918 | 70770851 |
H1N1 influenza | 55.59 | 9.89 | 44 | 152631 | 2346 | 70773423 |
Apathy | 55.10 | 9.89 | 95 | 152580 | 11813 | 70763956 |
Erythema | 54.77 | 9.89 | 232 | 152443 | 199331 | 70576438 |
Product administration error | 54.12 | 9.89 | 163 | 152512 | 29360 | 70746409 |
Gastrointestinal disorder | 53.76 | 9.89 | 90 | 152585 | 105337 | 70670432 |
Urinary hesitation | 53.55 | 9.89 | 52 | 152623 | 3647 | 70772122 |
Psoriasis | 53.05 | 9.89 | 81 | 152594 | 98352 | 70677417 |
Knee arthroplasty | 52.79 | 9.89 | 6 | 152669 | 34295 | 70741474 |
Pain in extremity | 51.83 | 9.89 | 454 | 152221 | 327628 | 70448141 |
Persecutory delusion | 51.78 | 9.89 | 56 | 152619 | 4461 | 70771308 |
Muscle injury | 51.73 | 9.89 | 10 | 152665 | 38484 | 70737285 |
Psychomotor retardation | 51.62 | 9.89 | 62 | 152613 | 5536 | 70770233 |
Parosmia | 51.12 | 9.89 | 58 | 152617 | 4873 | 70770896 |
Cardiac arrest | 49.88 | 9.89 | 545 | 152130 | 159289 | 70616480 |
Intentional product misuse | 49.45 | 9.89 | 317 | 152358 | 79278 | 70696491 |
Mental disorder | 49.04 | 9.89 | 153 | 152522 | 28087 | 70747682 |
Circulatory collapse | 49.04 | 9.89 | 178 | 152497 | 35296 | 70740473 |
Pneumonia | 48.61 | 9.89 | 948 | 151727 | 595284 | 70180485 |
Intestinal pseudo-obstruction | 48.07 | 9.89 | 40 | 152635 | 2290 | 70773479 |
Back pain | 47.95 | 9.89 | 364 | 152311 | 270788 | 70504981 |
Schizophrenia | 47.58 | 9.89 | 109 | 152566 | 16659 | 70759110 |
Lower respiratory tract infection | 47.12 | 9.89 | 107 | 152568 | 111806 | 70663963 |
Osteoarthritis | 47.12 | 9.89 | 54 | 152621 | 74093 | 70701676 |
Myelosuppression | 47.08 | 9.89 | 5 | 152670 | 30140 | 70745629 |
Herpes zoster | 47.04 | 9.89 | 69 | 152606 | 85166 | 70690603 |
Product monitoring error | 46.73 | 9.89 | 65 | 152610 | 6711 | 70769058 |
Platelet count decreased | 46.59 | 9.89 | 211 | 152464 | 178011 | 70597758 |
Acute psychosis | 45.68 | 9.89 | 49 | 152626 | 3867 | 70771902 |
Maternal exposure during pregnancy | 45.61 | 9.89 | 114 | 152561 | 115231 | 70660538 |
Helplessness | 45.42 | 9.89 | 20 | 152655 | 347 | 70775422 |
Aptyalism | 45.37 | 9.89 | 25 | 152650 | 717 | 70775052 |
Cytomegalovirus infection | 44.48 | 9.89 | 15 | 152660 | 39743 | 70736026 |
Pyrexia | 44.18 | 9.89 | 983 | 151692 | 605969 | 70169800 |
Cardiac failure congestive | 43.97 | 9.89 | 147 | 152528 | 135310 | 70640459 |
Epilepsy | 43.36 | 9.89 | 182 | 152493 | 38602 | 70737167 |
Injection site bruising | 43.16 | 9.89 | 14 | 152661 | 38018 | 70737751 |
Abulia | 42.54 | 9.89 | 26 | 152649 | 909 | 70774860 |
Galactorrhoea | 42.49 | 9.89 | 44 | 152631 | 3334 | 70772435 |
Menstrual disorder | 42.06 | 9.89 | 45 | 152630 | 3541 | 70772228 |
Priapism | 42.03 | 9.89 | 48 | 152627 | 4062 | 70771707 |
Hyperkinesia | 42.02 | 9.89 | 39 | 152636 | 2584 | 70773185 |
Fatigue | 41.88 | 9.89 | 1405 | 151270 | 822914 | 69952855 |
Incoherent | 41.56 | 9.89 | 64 | 152611 | 7242 | 70768527 |
Unresponsive to stimuli | 41.46 | 9.89 | 221 | 152454 | 51710 | 70724059 |
Antipsychotic drug level above therapeutic | 40.89 | 9.89 | 34 | 152641 | 1945 | 70773824 |
Injection site swelling | 40.69 | 9.89 | 21 | 152654 | 43136 | 70732633 |
Analgesic drug level above therapeutic | 40.53 | 9.89 | 20 | 152655 | 454 | 70775315 |
Bronchitis | 39.60 | 9.89 | 125 | 152550 | 117118 | 70658651 |
Polydipsia | 39.16 | 9.89 | 56 | 152619 | 5932 | 70769837 |
Wound | 38.71 | 9.89 | 98 | 152577 | 98634 | 70677135 |
Syncope | 38.68 | 9.89 | 535 | 152140 | 165174 | 70610595 |
Blood prolactin increased | 38.65 | 9.89 | 44 | 152631 | 3710 | 70772059 |
Impulsive behaviour | 38.53 | 9.89 | 38 | 152637 | 2716 | 70773053 |
Abnormal weight gain | 38.33 | 9.89 | 35 | 152640 | 2271 | 70773498 |
Coma scale abnormal | 37.88 | 9.89 | 65 | 152610 | 8051 | 70767718 |
Thrombocytopenia | 37.68 | 9.89 | 331 | 152344 | 238779 | 70536990 |
Neuropathy peripheral | 37.66 | 9.89 | 143 | 152532 | 126753 | 70649016 |
Therapeutic product ineffective | 37.46 | 9.89 | 30 | 152645 | 1627 | 70774142 |
Fungal infection | 37.20 | 9.89 | 17 | 152658 | 37450 | 70738319 |
Activation syndrome | 37.18 | 9.89 | 16 | 152659 | 262 | 70775507 |
Device expulsion | 36.58 | 9.89 | 3 | 152672 | 22243 | 70753526 |
Upper respiratory tract infection | 36.54 | 9.89 | 72 | 152603 | 79202 | 70696567 |
Accidental death | 35.57 | 9.89 | 43 | 152632 | 3865 | 70771904 |
COVID-19 | 35.54 | 9.89 | 113 | 152562 | 105644 | 70670125 |
Suspected suicide | 35.15 | 9.89 | 66 | 152609 | 8768 | 70767001 |
Septic shock | 34.96 | 9.89 | 124 | 152551 | 112134 | 70663635 |
Ill-defined disorder | 34.64 | 9.89 | 40 | 152635 | 54701 | 70721068 |
Muscle disorder | 34.37 | 9.89 | 49 | 152626 | 5176 | 70770593 |
Hip arthroplasty | 34.24 | 9.89 | 9 | 152666 | 28031 | 70747738 |
Social avoidant behaviour | 34.12 | 9.89 | 46 | 152629 | 4610 | 70771159 |
Osteoporosis | 34.01 | 9.89 | 33 | 152642 | 48874 | 70726895 |
Hyperreflexia | 33.95 | 9.89 | 59 | 152616 | 7383 | 70768386 |
Catatonia | 33.92 | 9.89 | 62 | 152613 | 8071 | 70767698 |
Acute motor-sensory axonal neuropathy | 33.86 | 9.89 | 17 | 152658 | 401 | 70775368 |
Feelings of worthlessness | 33.75 | 9.89 | 18 | 152657 | 483 | 70775286 |
Fracture | 33.66 | 9.89 | 107 | 152568 | 19837 | 70755932 |
Hypotonia | 33.52 | 9.89 | 77 | 152598 | 11788 | 70763981 |
Anaphylactic shock | 33.43 | 9.89 | 14 | 152661 | 32476 | 70743293 |
Blood pressure increased | 33.34 | 9.89 | 253 | 152422 | 188264 | 70587505 |
Inflammation | 33.28 | 9.89 | 75 | 152600 | 78590 | 70697179 |
Pallor | 33.13 | 9.89 | 175 | 152500 | 40799 | 70734970 |
Muscle twitching | 33.13 | 9.89 | 106 | 152569 | 19721 | 70756048 |
Diarrhoea | 32.86 | 9.89 | 1366 | 151309 | 781975 | 69993794 |
Merycism | 32.60 | 9.89 | 14 | 152661 | 228 | 70775541 |
Dysphagia | 32.59 | 9.89 | 379 | 152296 | 112455 | 70663314 |
Illness anxiety disorder | 32.27 | 9.89 | 14 | 152661 | 234 | 70775535 |
Cognitive disorder | 32.04 | 9.89 | 233 | 152442 | 60723 | 70715046 |
Gestational diabetes | 31.96 | 9.89 | 51 | 152624 | 5950 | 70769819 |
Headache | 31.86 | 9.89 | 979 | 151696 | 579426 | 70196343 |
Bursitis | 31.74 | 9.89 | 9 | 152666 | 26664 | 70749105 |
Cataract | 31.73 | 9.89 | 44 | 152631 | 55601 | 70720168 |
Bipolar disorder | 31.73 | 9.89 | 58 | 152617 | 7550 | 70768219 |
Rhinorrhoea | 31.71 | 9.89 | 59 | 152616 | 66312 | 70709457 |
Generalised tonic-clonic seizure | 31.70 | 9.89 | 175 | 152500 | 41486 | 70734283 |
Product dose omission issue | 31.26 | 9.89 | 308 | 152367 | 217160 | 70558609 |
Hyponatraemic coma | 30.95 | 9.89 | 9 | 152666 | 41 | 70775728 |
Electrocardiogram abnormal | 30.78 | 9.89 | 85 | 152590 | 14579 | 70761190 |
Acute myeloid leukaemia | 30.77 | 9.89 | 14 | 152661 | 30926 | 70744843 |
Hypoaesthesia oral | 30.63 | 9.89 | 76 | 152599 | 12224 | 70763545 |
Pressure of speech | 30.61 | 9.89 | 22 | 152653 | 1013 | 70774756 |
Decreased gait velocity | 30.60 | 9.89 | 12 | 152663 | 153 | 70775616 |
Thinking abnormal | 30.58 | 9.89 | 75 | 152600 | 11976 | 70763793 |
Mental impairment | 30.44 | 9.89 | 94 | 152581 | 17161 | 70758608 |
Sleep paralysis | 30.41 | 9.89 | 18 | 152657 | 593 | 70775176 |
Hypomania | 30.16 | 9.89 | 50 | 152625 | 6022 | 70769747 |
Bradypnoea | 29.91 | 9.89 | 47 | 152628 | 5412 | 70770357 |
Panic reaction | 29.50 | 9.89 | 41 | 152634 | 4230 | 70771539 |
Feeling guilty | 29.43 | 9.89 | 20 | 152655 | 841 | 70774928 |
Parkinsonian gait | 29.37 | 9.89 | 20 | 152655 | 844 | 70774925 |
Blood creatine phosphokinase increased | 29.29 | 9.89 | 229 | 152446 | 61034 | 70714735 |
JC virus infection | 29.00 | 9.89 | 37 | 152638 | 3514 | 70772255 |
Hyperthermia | 28.65 | 9.89 | 90 | 152585 | 16581 | 70759188 |
Multiple organ dysfunction syndrome | 28.63 | 9.89 | 128 | 152547 | 108387 | 70667382 |
Platypnoea | 28.34 | 9.89 | 8 | 152667 | 32 | 70775737 |
Sepsis | 28.20 | 9.89 | 364 | 152311 | 244181 | 70531588 |
Sarcopenia | 27.94 | 9.89 | 15 | 152660 | 408 | 70775361 |
Thrombotic microangiopathy | 27.77 | 9.89 | 3 | 152672 | 17845 | 70757924 |
Language disorder | 27.64 | 9.89 | 33 | 152642 | 2928 | 70772841 |
Serum serotonin increased | 27.53 | 9.89 | 13 | 152662 | 267 | 70775502 |
Sinus tachycardia | 27.53 | 9.89 | 145 | 152530 | 33768 | 70742001 |
Nephrolithiasis | 27.41 | 9.89 | 37 | 152638 | 47286 | 70728483 |
Mutism | 27.41 | 9.89 | 28 | 152647 | 2088 | 70773681 |
Antipsychotic drug level increased | 27.29 | 9.89 | 45 | 152630 | 5395 | 70770374 |
Ejaculation failure | 27.22 | 9.89 | 14 | 152661 | 348 | 70775421 |
Posture abnormal | 27.08 | 9.89 | 36 | 152639 | 3560 | 70772209 |
Blood pressure diastolic decreased | 26.70 | 9.89 | 11 | 152664 | 25769 | 70750000 |
Palmar-plantar erythrodysaesthesia syndrome | 26.66 | 9.89 | 16 | 152659 | 30231 | 70745538 |
Phagophobia | 26.58 | 9.89 | 8 | 152667 | 42 | 70775727 |
Tonic clonic movements | 26.58 | 9.89 | 27 | 152648 | 2000 | 70773769 |
Chest pain | 26.45 | 9.89 | 381 | 152294 | 250879 | 70524890 |
Fluid retention | 26.35 | 9.89 | 61 | 152614 | 63324 | 70712445 |
Medication error | 26.25 | 9.89 | 211 | 152464 | 56701 | 70719068 |
Balance disorder | 26.14 | 9.89 | 303 | 152372 | 89825 | 70685944 |
Pleural effusion | 26.07 | 9.89 | 173 | 152502 | 132691 | 70643078 |
Ataxia | 25.99 | 9.89 | 109 | 152566 | 23108 | 70752661 |
Crush syndrome | 25.62 | 9.89 | 11 | 152664 | 179 | 70775590 |
Wrong product administered | 25.62 | 9.89 | 56 | 152619 | 8295 | 70767474 |
Rash erythematous | 25.58 | 9.89 | 45 | 152630 | 51673 | 70724096 |
Basal cell carcinoma | 25.51 | 9.89 | 21 | 152654 | 33677 | 70742092 |
Disease progression | 25.51 | 9.89 | 215 | 152460 | 156457 | 70619312 |
Sudden death | 25.24 | 9.89 | 101 | 152574 | 20963 | 70754806 |
Macrophages increased | 24.82 | 9.89 | 11 | 152664 | 194 | 70775575 |
Mood altered | 24.78 | 9.89 | 85 | 152590 | 16390 | 70759379 |
Benign gastrointestinal neoplasm | 24.72 | 9.89 | 10 | 152665 | 139 | 70775630 |
Blood pressure systolic increased | 24.70 | 9.89 | 54 | 152621 | 57205 | 70718564 |
Akinesia | 24.59 | 9.89 | 32 | 152643 | 3099 | 70772670 |
Euphoric mood | 24.40 | 9.89 | 49 | 152626 | 6840 | 70768929 |
Somnambulism | 24.38 | 9.89 | 42 | 152633 | 5218 | 70770551 |
Agranulocytosis | 24.11 | 9.89 | 159 | 152516 | 40139 | 70735630 |
False positive investigation result | 24.10 | 9.89 | 18 | 152657 | 880 | 70774889 |
Atrial fibrillation | 24.08 | 9.89 | 267 | 152408 | 184081 | 70591688 |
Productive cough | 24.07 | 9.89 | 87 | 152588 | 78250 | 70697519 |
Erectile dysfunction | 24.03 | 9.89 | 74 | 152601 | 13488 | 70762281 |
Formication | 24.01 | 9.89 | 39 | 152636 | 4618 | 70771151 |
Tumour lysis syndrome | 23.99 | 9.89 | 8 | 152667 | 21352 | 70754417 |
Heart rate decreased | 23.96 | 9.89 | 62 | 152613 | 61953 | 70713816 |
Stoma site discharge | 23.88 | 9.89 | 24 | 152651 | 1755 | 70774014 |
Transplant rejection | 23.83 | 9.89 | 5 | 152670 | 18166 | 70757603 |
Premature labour | 23.81 | 9.89 | 53 | 152622 | 7947 | 70767822 |
Urogenital haemorrhage | 23.76 | 9.89 | 17 | 152658 | 777 | 70774992 |
Increased appetite | 23.76 | 9.89 | 63 | 152612 | 10550 | 70765219 |
Inappropriate schedule of product administration | 23.73 | 9.89 | 135 | 152540 | 107420 | 70668349 |
Chemical burn of oral cavity | 23.71 | 9.89 | 8 | 152667 | 64 | 70775705 |
Suicidal behaviour | 23.64 | 9.89 | 31 | 152644 | 3025 | 70772744 |
Rhonchi | 23.63 | 9.89 | 34 | 152641 | 3621 | 70772148 |
Pulmonary congestion | 23.56 | 9.89 | 112 | 152563 | 25042 | 70750727 |
Cardio-respiratory arrest | 23.46 | 9.89 | 325 | 152350 | 100352 | 70675417 |
Pyroglutamic acidosis | 22.96 | 9.89 | 17 | 152658 | 820 | 70774949 |
Hyporesponsive to stimuli | 22.93 | 9.89 | 24 | 152651 | 1841 | 70773928 |
Norepinephrine increased | 22.88 | 9.89 | 8 | 152667 | 72 | 70775697 |
Alcohol use | 22.85 | 9.89 | 38 | 152637 | 4589 | 70771180 |
Affective disorder | 22.77 | 9.89 | 50 | 152625 | 7429 | 70768340 |
Stupor | 22.70 | 9.89 | 46 | 152629 | 6463 | 70769306 |
Anticholinergic syndrome | 22.70 | 9.89 | 30 | 152645 | 2950 | 70772819 |
IVth nerve disorder | 22.58 | 9.89 | 6 | 152669 | 18 | 70775751 |
Therapeutic product effect incomplete | 22.57 | 9.89 | 158 | 152517 | 119724 | 70656045 |
Dyspnoea | 22.57 | 9.89 | 1393 | 151282 | 768667 | 70007102 |
Chorea | 22.50 | 9.89 | 25 | 152650 | 2053 | 70773716 |
Hypophagia | 22.48 | 9.89 | 160 | 152515 | 41410 | 70734359 |
Histrionic personality disorder | 22.47 | 9.89 | 7 | 152668 | 42 | 70775727 |
Ejaculation disorder | 22.39 | 9.89 | 14 | 152661 | 510 | 70775259 |
Gastrooesophageal reflux disease | 22.28 | 9.89 | 110 | 152565 | 90729 | 70685040 |
Malignant neoplasm progression | 22.17 | 9.89 | 162 | 152513 | 121577 | 70654192 |
Bulimia nervosa | 22.16 | 9.89 | 11 | 152664 | 253 | 70775516 |
Gait disturbance | 22.07 | 9.89 | 538 | 152137 | 184568 | 70591201 |
Myelodysplastic syndrome | 22.01 | 9.89 | 19 | 152656 | 29766 | 70746003 |
Potentiating drug interaction | 21.99 | 9.89 | 52 | 152623 | 8112 | 70767657 |
Anaphylactic reaction | 21.91 | 9.89 | 85 | 152590 | 74889 | 70700880 |
Oesophageal obstruction | 21.83 | 9.89 | 17 | 152658 | 885 | 70774884 |
Injection site haemorrhage | 21.81 | 9.89 | 14 | 152661 | 25513 | 70750256 |
Mucosal inflammation | 21.76 | 9.89 | 74 | 152601 | 67776 | 70707993 |
Delusion of grandeur | 21.74 | 9.89 | 17 | 152658 | 890 | 70774879 |
Electrocardiogram QRS complex prolonged | 21.74 | 9.89 | 58 | 152617 | 9748 | 70766021 |
Stoma site infection | 21.72 | 9.89 | 20 | 152655 | 1312 | 70774457 |
Glassy eyes | 21.57 | 9.89 | 9 | 152666 | 136 | 70775633 |
Thirst | 21.52 | 9.89 | 75 | 152600 | 14574 | 70761195 |
Opisthotonus | 21.33 | 9.89 | 15 | 152660 | 667 | 70775102 |
Food craving | 21.30 | 9.89 | 21 | 152654 | 1500 | 70774269 |
Alcoholism | 21.27 | 9.89 | 36 | 152639 | 4409 | 70771360 |
Joint range of motion decreased | 21.26 | 9.89 | 15 | 152660 | 26011 | 70749758 |
Psychiatric decompensation | 21.12 | 9.89 | 29 | 152646 | 2958 | 70772811 |
Neglect of personal appearance | 21.10 | 9.89 | 9 | 152666 | 144 | 70775625 |
Acute myocardial infarction | 21.06 | 9.89 | 83 | 152592 | 72804 | 70702965 |
Haematemesis | 20.95 | 9.89 | 178 | 152497 | 48619 | 70727150 |
Sensory loss | 20.88 | 9.89 | 63 | 152612 | 11356 | 70764413 |
Psychotic symptom | 20.86 | 9.89 | 26 | 152649 | 2412 | 70773357 |
Injection site reaction | 20.70 | 9.89 | 48 | 152627 | 49804 | 70725965 |
Cytokine release syndrome | 20.66 | 9.89 | 16 | 152659 | 26451 | 70749318 |
Prostate cancer | 20.56 | 9.89 | 22 | 152653 | 31141 | 70744628 |
Dementia | 20.53 | 9.89 | 99 | 152576 | 22266 | 70753503 |
Tendonitis | 20.50 | 9.89 | 11 | 152664 | 22111 | 70753658 |
Osteomyelitis | 20.46 | 9.89 | 21 | 152654 | 30297 | 70745472 |
Influenza | 20.37 | 9.89 | 152 | 152523 | 113548 | 70662221 |
Skin necrosis | 20.33 | 9.89 | 5 | 152670 | 16286 | 70759483 |
Hanging | 20.33 | 9.89 | 8 | 152667 | 103 | 70775666 |
Vestibular disorder | 20.26 | 9.89 | 25 | 152650 | 2295 | 70773474 |
Congenital cerebrovascular anomaly | 20.25 | 9.89 | 5 | 152670 | 10 | 70775759 |
Bladder cancer | 20.18 | 9.89 | 6 | 152669 | 17236 | 70758533 |
Sudden cardiac death | 20.07 | 9.89 | 37 | 152638 | 4848 | 70770921 |
Obsessive-compulsive disorder | 19.99 | 9.89 | 39 | 152636 | 5331 | 70770438 |
Conjunctivitis | 19.91 | 9.89 | 12 | 152663 | 22624 | 70753145 |
Hallucination, synaesthetic | 19.83 | 9.89 | 7 | 152668 | 65 | 70775704 |
Postictal state | 19.79 | 9.89 | 21 | 152654 | 1637 | 70774132 |
Pulmonary arterial hypertension | 19.73 | 9.89 | 25 | 152650 | 32830 | 70742939 |
Faecaloma | 19.43 | 9.89 | 58 | 152617 | 10393 | 70765376 |
Rapid eye movements sleep abnormal | 19.43 | 9.89 | 10 | 152665 | 249 | 70775520 |
CYP3A4 polymorphism | 19.37 | 9.89 | 7 | 152668 | 70 | 70775699 |
Sleep terror | 19.34 | 9.89 | 18 | 152657 | 1197 | 70774572 |
Amnesia | 19.19 | 9.89 | 184 | 152491 | 51971 | 70723798 |
Fibromyalgia | 19.16 | 9.89 | 47 | 152628 | 47827 | 70727942 |
Cold sweat | 19.13 | 9.89 | 80 | 152595 | 16936 | 70758833 |
Hypersomnia | 19.12 | 9.89 | 92 | 152583 | 20672 | 70755097 |
Failure to thrive | 19.11 | 9.89 | 59 | 152616 | 10770 | 70764999 |
Obsessive-compulsive personality disorder | 19.10 | 9.89 | 8 | 152667 | 122 | 70775647 |
Oropharyngeal pain | 19.09 | 9.89 | 125 | 152550 | 96185 | 70679584 |
Aspiration | 19.02 | 9.89 | 82 | 152593 | 17593 | 70758176 |
Treatment noncompliance | 19.00 | 9.89 | 168 | 152507 | 46406 | 70729363 |
White blood cell count decreased | 18.96 | 9.89 | 255 | 152420 | 169886 | 70605883 |
Breast discomfort | 18.87 | 9.89 | 11 | 152664 | 352 | 70775417 |
Blood bilirubin decreased | 18.86 | 9.89 | 16 | 152659 | 941 | 70774828 |
Emotional disorder | 18.82 | 9.89 | 67 | 152608 | 13159 | 70762610 |
Alcohol interaction | 18.81 | 9.89 | 35 | 152640 | 4618 | 70771151 |
Labelled drug-drug interaction medication error | 18.79 | 9.89 | 102 | 152573 | 24025 | 70751744 |
Bezoar | 18.79 | 9.89 | 24 | 152651 | 2282 | 70773487 |
Paralysis | 18.78 | 9.89 | 63 | 152612 | 12009 | 70763760 |
Hypervigilance | 18.72 | 9.89 | 12 | 152663 | 457 | 70775312 |
Cyanosis | 18.68 | 9.89 | 99 | 152576 | 23107 | 70752662 |
Self-injurious ideation | 18.65 | 9.89 | 29 | 152646 | 3309 | 70772460 |
Sexual dysfunction | 18.48 | 9.89 | 43 | 152632 | 6638 | 70769131 |
Coronary artery disease | 18.41 | 9.89 | 71 | 152604 | 62665 | 70713104 |
Binge eating | 18.30 | 9.89 | 12 | 152663 | 475 | 70775294 |
Pseudomonas infection | 18.27 | 9.89 | 9 | 152666 | 18985 | 70756784 |
Osteonecrosis of jaw | 18.24 | 9.89 | 38 | 152637 | 40964 | 70734805 |
Thymus disorder | 18.23 | 9.89 | 10 | 152665 | 284 | 70775485 |
Tracheal pain | 18.23 | 9.89 | 6 | 152669 | 44 | 70775725 |
Amnestic disorder | 18.21 | 9.89 | 13 | 152662 | 592 | 70775177 |
Respiratory rate decreased | 18.13 | 9.89 | 35 | 152640 | 4747 | 70771022 |
Sputum discoloured | 18.03 | 9.89 | 9 | 152666 | 18842 | 70756927 |
Stoma site inflammation | 18.02 | 9.89 | 13 | 152662 | 602 | 70775167 |
Autonomic nervous system imbalance | 18.00 | 9.89 | 33 | 152642 | 4306 | 70771463 |
Decreased interest | 17.99 | 9.89 | 29 | 152646 | 3412 | 70772357 |
Salivary hypersecretion | 17.98 | 9.89 | 65 | 152610 | 12860 | 70762909 |
Decreased appetite | 17.95 | 9.89 | 815 | 151860 | 303965 | 70471804 |
Sensory disturbance | 17.94 | 9.89 | 68 | 152607 | 13764 | 70762005 |
Natural killer cell count decreased | 17.89 | 9.89 | 6 | 152669 | 47 | 70775722 |
Patient elopement | 17.89 | 9.89 | 6 | 152669 | 47 | 70775722 |
Red blood cell sedimentation rate increased | 17.89 | 9.89 | 35 | 152640 | 38607 | 70737162 |
Negative thoughts | 17.73 | 9.89 | 18 | 152657 | 1332 | 70774437 |
Eosinophilic pleural effusion | 17.71 | 9.89 | 10 | 152665 | 301 | 70775468 |
Drug dose titration not performed | 17.71 | 9.89 | 14 | 152661 | 745 | 70775024 |
Dementia with Lewy bodies | 17.68 | 9.89 | 14 | 152661 | 747 | 70775022 |
Skin lesion | 17.66 | 9.89 | 35 | 152640 | 38425 | 70737344 |
Ear infection | 17.61 | 9.89 | 21 | 152654 | 28315 | 70747454 |
Mitral valve incompetence | 17.49 | 9.89 | 19 | 152656 | 26709 | 70749060 |
Postoperative respiratory failure | 17.41 | 9.89 | 8 | 152667 | 154 | 70775615 |
Oedema | 17.37 | 9.89 | 141 | 152534 | 103440 | 70672329 |
Postmortem blood drug level increased | 17.32 | 9.89 | 14 | 152661 | 769 | 70775000 |
Disinhibition | 17.27 | 9.89 | 23 | 152652 | 2278 | 70773491 |
Haemoptysis | 17.26 | 9.89 | 55 | 152620 | 51397 | 70724372 |
JC virus CSF test positive | 17.23 | 9.89 | 8 | 152667 | 158 | 70775611 |
Communication disorder | 17.20 | 9.89 | 30 | 152645 | 3764 | 70772005 |
Drowning | 17.18 | 9.89 | 14 | 152661 | 778 | 70774991 |
Blood sodium decreased | 17.17 | 9.89 | 120 | 152555 | 30878 | 70744891 |
Psychomotor skills impaired | 17.04 | 9.89 | 32 | 152643 | 4252 | 70771517 |
Clonus | 16.97 | 9.89 | 40 | 152635 | 6228 | 70769541 |
Immune reconstitution inflammatory syndrome | 16.96 | 9.89 | 64 | 152611 | 12926 | 70762843 |
Antidepressant drug level decreased | 16.92 | 9.89 | 4 | 152671 | 6 | 70775763 |
Reduced facial expression | 16.88 | 9.89 | 23 | 152652 | 2329 | 70773440 |
Nasal discomfort | 16.83 | 9.89 | 34 | 152641 | 4767 | 70771002 |
Sensorimotor disorder | 16.82 | 9.89 | 14 | 152661 | 802 | 70774967 |
Wheezing | 16.81 | 9.89 | 126 | 152549 | 94044 | 70681725 |
Blood osmolarity decreased | 16.79 | 9.89 | 17 | 152658 | 1254 | 70774515 |
Loose associations | 16.69 | 9.89 | 6 | 152669 | 59 | 70775710 |
Staphylococcal infection | 16.61 | 9.89 | 59 | 152616 | 53345 | 70722424 |
Drug screen positive | 16.61 | 9.89 | 38 | 152637 | 5802 | 70769967 |
Somatic delusion | 16.52 | 9.89 | 13 | 152662 | 687 | 70775082 |
Skin ulcer | 16.48 | 9.89 | 51 | 152624 | 48094 | 70727675 |
Premature delivery | 16.47 | 9.89 | 13 | 152662 | 21291 | 70754478 |
Drug dispensed to wrong patient | 16.44 | 9.89 | 12 | 152663 | 566 | 70775203 |
Cellulitis | 16.44 | 9.89 | 135 | 152540 | 98793 | 70676976 |
Haemophagocytic lymphohistiocytosis | 16.43 | 9.89 | 11 | 152664 | 19601 | 70756168 |
Facial nerve disorder | 16.36 | 9.89 | 13 | 152662 | 697 | 70775072 |
Somatic symptom disorder | 16.34 | 9.89 | 21 | 152654 | 2009 | 70773760 |
Respiratory acidosis | 16.30 | 9.89 | 54 | 152621 | 10227 | 70765542 |
Skin exfoliation | 16.30 | 9.89 | 52 | 152623 | 48574 | 70727195 |
Product prescribing issue | 16.26 | 9.89 | 26 | 152649 | 3038 | 70772731 |
Purple glove syndrome | 16.24 | 9.89 | 9 | 152666 | 261 | 70775508 |
Rash pruritic | 16.19 | 9.89 | 75 | 152600 | 62916 | 70712853 |
Therapy non-responder | 16.19 | 9.89 | 98 | 152577 | 76817 | 70698952 |
Homicide | 16.10 | 9.89 | 16 | 152659 | 1154 | 70774615 |
Acne | 16.09 | 9.89 | 18 | 152657 | 24971 | 70750798 |
Tricuspid valve sclerosis | 16.05 | 9.89 | 5 | 152670 | 30 | 70775739 |
Status epilepticus | 16.05 | 9.89 | 99 | 152576 | 24427 | 70751342 |
Blood pressure systolic abnormal | 16.04 | 9.89 | 4 | 152671 | 12905 | 70762864 |
Tachypnoea | 15.94 | 9.89 | 111 | 152564 | 28527 | 70747242 |
Swollen tongue | 15.83 | 9.89 | 135 | 152540 | 36911 | 70738858 |
Drop attacks | 15.82 | 9.89 | 15 | 152660 | 1021 | 70774748 |
Hypertension | 15.79 | 9.89 | 501 | 152174 | 295532 | 70480237 |
Dyspraxia | 15.76 | 9.89 | 9 | 152666 | 277 | 70775492 |
Suspiciousness | 15.73 | 9.89 | 12 | 152663 | 606 | 70775163 |
Dissociative disorder | 15.69 | 9.89 | 11 | 152664 | 487 | 70775282 |
Neck pain | 15.62 | 9.89 | 82 | 152593 | 66575 | 70709194 |
Neutrophil count increased | 15.59 | 9.89 | 105 | 152570 | 26690 | 70749079 |
Sinus congestion | 15.58 | 9.89 | 9 | 152666 | 17364 | 70758405 |
Stoma site erythema | 15.55 | 9.89 | 17 | 152658 | 1371 | 70774398 |
Renal failure | 15.52 | 9.89 | 300 | 152375 | 188770 | 70586999 |
Resuscitation | 15.49 | 9.89 | 22 | 152653 | 2315 | 70773454 |
Renal disorder | 15.46 | 9.89 | 37 | 152638 | 37972 | 70737797 |
Gout | 15.45 | 9.89 | 16 | 152659 | 22990 | 70752779 |
Blood pressure diastolic abnormal | 15.44 | 9.89 | 7 | 152668 | 15497 | 70760272 |
Tachycardia paroxysmal | 15.43 | 9.89 | 10 | 152665 | 388 | 70775381 |
Cerebral mass effect | 15.43 | 9.89 | 19 | 152656 | 1741 | 70774028 |
Vertigo | 15.32 | 9.89 | 204 | 152471 | 62439 | 70713330 |
Antidepressant drug level increased | 15.32 | 9.89 | 10 | 152665 | 393 | 70775376 |
Anorgasmia | 15.23 | 9.89 | 15 | 152660 | 1070 | 70774699 |
Haemoglobin decreased | 15.22 | 9.89 | 331 | 152344 | 204828 | 70570941 |
Self esteem decreased | 15.19 | 9.89 | 14 | 152661 | 919 | 70774850 |
Bacterial infection | 15.05 | 9.89 | 21 | 152654 | 26471 | 70749298 |
Aspergillus infection | 14.99 | 9.89 | 10 | 152665 | 17858 | 70757911 |
Circadian rhythm sleep disorder | 14.98 | 9.89 | 12 | 152663 | 651 | 70775118 |
Rash maculo-papular | 14.96 | 9.89 | 57 | 152618 | 50488 | 70725281 |
Behaviour disorder | 14.93 | 9.89 | 35 | 152640 | 5429 | 70770340 |
Lung disorder | 14.90 | 9.89 | 88 | 152587 | 69396 | 70706373 |
Prostatism | 14.79 | 9.89 | 6 | 152669 | 84 | 70775685 |
Epstein-Barr virus infection | 14.72 | 9.89 | 5 | 152670 | 13193 | 70762576 |
Neoplasm progression | 14.72 | 9.89 | 49 | 152626 | 45179 | 70730590 |
Hypothermia | 14.67 | 9.89 | 85 | 152590 | 20509 | 70755260 |
Flushing | 14.64 | 9.89 | 110 | 152565 | 82062 | 70693707 |
Lower limb fracture | 14.60 | 9.89 | 9 | 152666 | 16763 | 70759006 |
Giant cell arteritis | 14.46 | 9.89 | 22 | 152653 | 2463 | 70773306 |
Diverticulitis | 14.43 | 9.89 | 44 | 152631 | 41690 | 70734079 |
Liver injury | 14.38 | 9.89 | 43 | 152632 | 40992 | 70734777 |
Pulmonary oedema | 14.36 | 9.89 | 253 | 152422 | 82025 | 70693744 |
Drug abuser | 14.35 | 9.89 | 36 | 152639 | 5828 | 70769941 |
Hepatic steatosis | 14.33 | 9.89 | 123 | 152552 | 33690 | 70742079 |
Liver disorder | 14.28 | 9.89 | 76 | 152599 | 61492 | 70714277 |
Pulmonary fibrosis | 14.28 | 9.89 | 33 | 152642 | 34277 | 70741492 |
Fear | 14.25 | 9.89 | 85 | 152590 | 20726 | 70755043 |
Disseminated intravascular coagulation | 14.23 | 9.89 | 32 | 152643 | 33566 | 70742203 |
Violence-related symptom | 14.23 | 9.89 | 12 | 152663 | 700 | 70775069 |
Wrong technique in product usage process | 14.21 | 9.89 | 88 | 152587 | 68610 | 70707159 |
Blood osmolarity increased | 14.15 | 9.89 | 11 | 152664 | 571 | 70775198 |
Sinus disorder | 14.12 | 9.89 | 12 | 152663 | 18947 | 70756822 |
Cachexia | 13.96 | 9.89 | 50 | 152625 | 9850 | 70765919 |
Cardiac failure | 13.94 | 9.89 | 221 | 152454 | 143320 | 70632449 |
Creatinine renal clearance decreased | 13.94 | 9.89 | 10 | 152665 | 17190 | 70758579 |
Impaired self-care | 13.93 | 9.89 | 21 | 152654 | 2333 | 70773436 |
Limited symptom panic attack | 13.92 | 9.89 | 5 | 152670 | 49 | 70775720 |
Oral herpes | 13.91 | 9.89 | 19 | 152656 | 24167 | 70751602 |
Loss of proprioception | 13.90 | 9.89 | 12 | 152663 | 723 | 70775046 |
Ascites | 13.73 | 9.89 | 87 | 152588 | 67460 | 70708309 |
Orgasm abnormal | 13.72 | 9.89 | 7 | 152668 | 171 | 70775598 |
Hypervolaemia | 13.63 | 9.89 | 42 | 152633 | 39664 | 70736105 |
Dysphoria | 13.61 | 9.89 | 30 | 152645 | 4468 | 70771301 |
Hypernatraemia | 13.58 | 9.89 | 59 | 152616 | 12702 | 70763067 |
Emotional poverty | 13.55 | 9.89 | 12 | 152663 | 748 | 70775021 |
Ocular hyperaemia | 13.54 | 9.89 | 20 | 152655 | 24619 | 70751150 |
Eyelid myoclonus | 13.53 | 9.89 | 6 | 152669 | 106 | 70775663 |
Indifference | 13.50 | 9.89 | 8 | 152667 | 264 | 70775505 |
Dyspnoea exertional | 13.50 | 9.89 | 106 | 152569 | 78324 | 70697445 |
Generalised anxiety disorder | 13.48 | 9.89 | 19 | 152656 | 1986 | 70773783 |
Vasodilatation | 13.46 | 9.89 | 24 | 152651 | 3064 | 70772705 |
Panic disorder | 13.45 | 9.89 | 23 | 152652 | 2841 | 70772928 |
Mass | 13.41 | 9.89 | 9 | 152666 | 16017 | 70759752 |
Arrhythmia | 13.38 | 9.89 | 182 | 152493 | 55961 | 70719808 |
Neoplasm malignant | 13.37 | 9.89 | 26 | 152649 | 28748 | 70747021 |
Respiratory tract congestion | 13.37 | 9.89 | 11 | 152664 | 17642 | 70758127 |
Kidney congestion | 13.21 | 9.89 | 8 | 152667 | 275 | 70775494 |
Compulsive shopping | 13.18 | 9.89 | 12 | 152663 | 776 | 70774993 |
Poverty of thought content | 13.17 | 9.89 | 5 | 152670 | 58 | 70775711 |
Foot deformity | 13.17 | 9.89 | 15 | 152660 | 20640 | 70755129 |
Oesophageal haemorrhage | 13.13 | 9.89 | 17 | 152658 | 1638 | 70774131 |
Paresis | 13.08 | 9.89 | 27 | 152648 | 3843 | 70771926 |
Dysgraphia | 13.06 | 9.89 | 26 | 152649 | 3606 | 70772163 |
Anaemia | 12.98 | 9.89 | 723 | 151952 | 402700 | 70373069 |
Blood ethanol increased | 12.97 | 9.89 | 11 | 152664 | 647 | 70775122 |
Thrombosis | 12.94 | 9.89 | 102 | 152573 | 75303 | 70700466 |
COVID-19 pneumonia | 12.90 | 9.89 | 17 | 152658 | 21952 | 70753817 |
Post-traumatic stress disorder | 12.89 | 9.89 | 29 | 152646 | 4378 | 70771391 |
Dependence | 12.88 | 9.89 | 20 | 152655 | 2280 | 70773489 |
Kussmaul respiration | 12.86 | 9.89 | 9 | 152666 | 397 | 70775372 |
Second primary malignancy | 12.83 | 9.89 | 6 | 152669 | 13045 | 70762724 |
Neutropenia | 12.81 | 9.89 | 439 | 152236 | 256717 | 70519052 |
Frequent bowel movements | 12.80 | 9.89 | 16 | 152659 | 21137 | 70754632 |
Antiphospholipid antibodies | 12.76 | 9.89 | 6 | 152669 | 122 | 70775647 |
Spinal cord injury thoracic | 12.76 | 9.89 | 6 | 152669 | 122 | 70775647 |
Ballismus | 12.76 | 9.89 | 7 | 152668 | 199 | 70775570 |
Injection site rash | 12.71 | 9.89 | 10 | 152665 | 16400 | 70759369 |
Blood creatinine increased | 12.64 | 9.89 | 224 | 152451 | 142777 | 70632992 |
Electroencephalogram abnormal | 12.58 | 9.89 | 32 | 152643 | 5226 | 70770543 |
Mean cell haemoglobin decreased | 12.54 | 9.89 | 32 | 152643 | 5236 | 70770533 |
Hangover | 12.53 | 9.89 | 18 | 152657 | 1915 | 70773854 |
Polydipsia psychogenic | 12.48 | 9.89 | 7 | 152668 | 208 | 70775561 |
Contusion | 12.48 | 9.89 | 197 | 152478 | 127839 | 70647930 |
Visceral congestion | 12.47 | 9.89 | 12 | 152663 | 832 | 70774937 |
Pneumocystis jirovecii pneumonia | 12.46 | 9.89 | 29 | 152646 | 30053 | 70745716 |
Regressive behaviour | 12.46 | 9.89 | 6 | 152669 | 129 | 70775640 |
Dystrophic calcification | 12.41 | 9.89 | 6 | 152669 | 130 | 70775639 |
Pulmonary vein occlusion | 12.37 | 9.89 | 6 | 152669 | 131 | 70775638 |
Hyperthyroidism | 12.37 | 9.89 | 15 | 152660 | 20076 | 70755693 |
Surgery | 12.35 | 9.89 | 29 | 152646 | 29960 | 70745809 |
Death | 12.35 | 9.89 | 1266 | 151409 | 508795 | 70266974 |
Enthesopathy | 12.33 | 9.89 | 4 | 152671 | 10865 | 70764904 |
Drug tolerance decreased | 12.31 | 9.89 | 3 | 152672 | 9830 | 70765939 |
Sneezing | 12.30 | 9.89 | 11 | 152664 | 16940 | 70758829 |
Light chain disease | 12.27 | 9.89 | 7 | 152668 | 215 | 70775554 |
Arachnoid cyst | 12.22 | 9.89 | 8 | 152667 | 316 | 70775453 |
Plasma cell myeloma | 12.11 | 9.89 | 100 | 152575 | 73101 | 70702668 |
Oxygen saturation decreased | 12.08 | 9.89 | 177 | 152498 | 116252 | 70659517 |
Agonal rhythm | 12.08 | 9.89 | 5 | 152670 | 74 | 70775695 |
Cytomegalovirus viraemia | 12.08 | 9.89 | 5 | 152670 | 11680 | 70764089 |
Sialoadenitis | 12.07 | 9.89 | 17 | 152658 | 1775 | 70773994 |
Drug eruption | 12.04 | 9.89 | 44 | 152631 | 39452 | 70736317 |
Therapeutic response decreased | 12.03 | 9.89 | 75 | 152600 | 58378 | 70717391 |
Immunodeficiency | 12.03 | 9.89 | 12 | 152663 | 17543 | 70758226 |
Increased tendency to bruise | 12.01 | 9.89 | 3 | 152672 | 9672 | 70766097 |
Injection site urticaria | 12.00 | 9.89 | 5 | 152670 | 11633 | 70764136 |
Abdominal pain upper | 11.98 | 9.89 | 321 | 152354 | 193281 | 70582488 |
Pulmonary renal syndrome | 11.97 | 9.89 | 10 | 152665 | 576 | 70775193 |
Basophil count decreased | 11.95 | 9.89 | 7 | 152668 | 226 | 70775543 |
Accidental poisoning | 11.94 | 9.89 | 16 | 152659 | 1594 | 70774175 |
Repetitive speech | 11.91 | 9.89 | 8 | 152667 | 330 | 70775439 |
Tenderness | 11.86 | 9.89 | 17 | 152658 | 21193 | 70754576 |
Hypokalaemia | 11.86 | 9.89 | 368 | 152307 | 130820 | 70644949 |
Eosinophilic myocarditis | 11.86 | 9.89 | 12 | 152663 | 885 | 70774884 |
Haemolysis | 11.85 | 9.89 | 5 | 152670 | 11546 | 70764223 |
Libido decreased | 11.85 | 9.89 | 30 | 152645 | 4886 | 70770883 |
Cellulitis orbital | 11.84 | 9.89 | 11 | 152664 | 730 | 70775039 |
B-lymphocyte count increased | 11.82 | 9.89 | 6 | 152669 | 145 | 70775624 |
Inferior vena caval occlusion | 11.75 | 9.89 | 4 | 152671 | 33 | 70775736 |
Pathogen resistance | 11.74 | 9.89 | 7 | 152668 | 13272 | 70762497 |
Implant site extravasation | 11.72 | 9.89 | 11 | 152664 | 739 | 70775030 |
Bone density decreased | 11.71 | 9.89 | 5 | 152670 | 11469 | 70764300 |
Alkalosis hypochloraemic | 11.70 | 9.89 | 9 | 152666 | 460 | 70775309 |
Essential tremor | 11.69 | 9.89 | 15 | 152660 | 1432 | 70774337 |
Abdominal rigidity | 11.67 | 9.89 | 21 | 152654 | 2700 | 70773069 |
Accidental exposure to product | 11.65 | 9.89 | 27 | 152648 | 28024 | 70747745 |
Antipsychotic drug level decreased | 11.64 | 9.89 | 13 | 152662 | 1073 | 70774696 |
Grip strength decreased | 11.60 | 9.89 | 10 | 152665 | 15675 | 70760094 |
Pharyngitis streptococcal | 11.60 | 9.89 | 3 | 152672 | 9445 | 70766324 |
Convulsive threshold lowered | 11.56 | 9.89 | 12 | 152663 | 912 | 70774857 |
Memory impairment | 11.56 | 9.89 | 271 | 152404 | 92370 | 70683399 |
Bacteraemia | 11.55 | 9.89 | 29 | 152646 | 29280 | 70746489 |
Rabbit syndrome | 11.55 | 9.89 | 8 | 152667 | 347 | 70775422 |
Hepatotoxicity | 11.53 | 9.89 | 52 | 152623 | 43934 | 70731835 |
Blood pressure fluctuation | 11.49 | 9.89 | 77 | 152598 | 58935 | 70716834 |
C-reactive protein increased | 11.47 | 9.89 | 168 | 152507 | 110349 | 70665420 |
Extensor plantar response | 11.41 | 9.89 | 16 | 152659 | 1664 | 70774105 |
Perforated ulcer | 11.32 | 9.89 | 10 | 152665 | 621 | 70775148 |
Drug withdrawal headache | 11.29 | 9.89 | 5 | 152670 | 88 | 70775681 |
Blood cholesterol increased | 11.27 | 9.89 | 87 | 152588 | 64517 | 70711252 |
Injection site warmth | 11.25 | 9.89 | 8 | 152667 | 13817 | 70761952 |
Bipolar I disorder | 11.20 | 9.89 | 17 | 152658 | 1900 | 70773869 |
Bronchial aspiration procedure | 11.20 | 9.89 | 7 | 152668 | 255 | 70775514 |
Verbal abuse | 11.15 | 9.89 | 7 | 152668 | 257 | 70775512 |
Alcohol abuse | 11.11 | 9.89 | 30 | 152645 | 5077 | 70770692 |
Toxicologic test abnormal | 11.11 | 9.89 | 14 | 152661 | 1313 | 70774456 |
Radial nerve injury | 11.07 | 9.89 | 4 | 152671 | 40 | 70775729 |
Skin infection | 11.05 | 9.89 | 11 | 152664 | 16101 | 70759668 |
Personality change | 11.01 | 9.89 | 43 | 152632 | 8827 | 70766942 |
Gamma-glutamyltransferase abnormal | 10.99 | 9.89 | 9 | 152666 | 504 | 70775265 |
Obstructive airways disorder | 10.96 | 9.89 | 25 | 152650 | 26088 | 70749681 |
Tongue movement disturbance | 10.93 | 9.89 | 8 | 152667 | 379 | 70775390 |
Spontaneous haemorrhage | 10.90 | 9.89 | 9 | 152666 | 510 | 70775259 |
Brain oedema | 10.89 | 9.89 | 87 | 152588 | 23331 | 70752438 |
Lymphadenopathy | 10.89 | 9.89 | 61 | 152614 | 48730 | 70727039 |
Dry skin | 10.88 | 9.89 | 73 | 152602 | 55858 | 70719911 |
Hyperuricaemia | 10.85 | 9.89 | 5 | 152670 | 10961 | 70764808 |
Carbon monoxide poisoning | 10.84 | 9.89 | 7 | 152668 | 270 | 70775499 |
Coagulopathy | 10.84 | 9.89 | 36 | 152639 | 33213 | 70742556 |
Shared psychotic disorder | 10.81 | 9.89 | 4 | 152671 | 43 | 70775726 |
Sciatica | 10.81 | 9.89 | 23 | 152652 | 24604 | 70751165 |
Labelled drug-disease interaction issue | 10.73 | 9.89 | 4 | 152671 | 44 | 70775725 |
Mood disorder due to a general medical condition | 10.73 | 9.89 | 4 | 152671 | 44 | 70775725 |
Gastric cancer | 10.70 | 9.89 | 3 | 152672 | 8952 | 70766817 |
Foot fracture | 10.68 | 9.89 | 16 | 152659 | 19584 | 70756185 |
Hypertriglyceridaemia | 10.64 | 9.89 | 52 | 152623 | 11759 | 70764010 |
Bronchopulmonary aspergillosis | 10.63 | 9.89 | 18 | 152657 | 20984 | 70754785 |
Jealous delusion | 10.61 | 9.89 | 7 | 152668 | 280 | 70775489 |
Coordination abnormal | 10.60 | 9.89 | 65 | 152610 | 16001 | 70759768 |
Disorganised speech | 10.56 | 9.89 | 16 | 152659 | 1785 | 70773984 |
Cerebral atrophy | 10.54 | 9.89 | 38 | 152637 | 7509 | 70768260 |
Ulcer | 10.53 | 9.89 | 25 | 152650 | 25729 | 70750040 |
Personality disorder | 10.52 | 9.89 | 31 | 152644 | 5517 | 70770252 |
Unemployment | 10.42 | 9.89 | 4 | 152671 | 48 | 70775721 |
Injury | 10.40 | 9.89 | 90 | 152585 | 65155 | 70710614 |
Gambling | 10.37 | 9.89 | 7 | 152668 | 291 | 70775478 |
Eye disorder | 10.35 | 9.89 | 18 | 152657 | 20767 | 70755002 |
No adverse event | 10.35 | 9.89 | 35 | 152640 | 32118 | 70743651 |
Peripheral T-cell lymphoma unspecified recurrent | 10.34 | 9.89 | 4 | 152671 | 49 | 70775720 |
Upper-airway cough syndrome | 10.32 | 9.89 | 4 | 152671 | 9727 | 70766042 |
Resting tremor | 10.32 | 9.89 | 14 | 152661 | 1412 | 70774357 |
Insulin resistance | 10.30 | 9.89 | 13 | 152662 | 1221 | 70774548 |
Nephrotic syndrome | 10.30 | 9.89 | 5 | 152670 | 10635 | 70765134 |
Chronic kidney disease | 10.29 | 9.89 | 83 | 152592 | 60974 | 70714795 |
Aphasia | 10.23 | 9.89 | 140 | 152535 | 43109 | 70732660 |
Autoimmune disorder | 10.23 | 9.89 | 3 | 152672 | 8693 | 70767076 |
Peritonitis | 10.22 | 9.89 | 26 | 152649 | 26133 | 70749636 |
Abscess | 10.19 | 9.89 | 18 | 152657 | 20636 | 70755133 |
Full blood count abnormal | 10.16 | 9.89 | 38 | 152637 | 33840 | 70741929 |
Joint effusion | 10.13 | 9.89 | 11 | 152664 | 15466 | 70760303 |
Spinal stenosis | 10.06 | 9.89 | 10 | 152665 | 14643 | 70761126 |
Breast cancer female | 10.04 | 9.89 | 5 | 152670 | 10481 | 70765288 |
Aspergillus test positive | 10.03 | 9.89 | 10 | 152665 | 724 | 70775045 |
Hypercalcaemia | 10.03 | 9.89 | 39 | 152636 | 34346 | 70741423 |
Hepatocellular injury | 10.02 | 9.89 | 147 | 152528 | 45944 | 70729825 |
Partner stress | 9.96 | 9.89 | 7 | 152668 | 311 | 70775458 |
Chemical burns of eye | 9.96 | 9.89 | 5 | 152670 | 118 | 70775651 |
Post viral fatigue syndrome | 9.94 | 9.89 | 7 | 152668 | 312 | 70775457 |
Loss of personal independence in daily activities | 9.92 | 9.89 | 126 | 152549 | 84784 | 70690985 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Neonatal seizure | 36.23 | 30.88 | 28 | 595 | 437 | 88732 |
Source | Code | Description |
---|---|---|
ATC | N06AX11 | NERVOUS SYSTEM PSYCHOANALEPTICS ANTIDEPRESSANTS Other antidepressants |
MeSH PA | D018663 | Adrenergic Agents |
MeSH PA | D058669 | Adrenergic alpha-2 Receptor Antagonists |
MeSH PA | D000317 | Adrenergic alpha-Antagonists |
MeSH PA | D018674 | Adrenergic Antagonists |
MeSH PA | D014151 | Anti-Anxiety Agents |
MeSH PA | D000928 | Antidepressive Agents |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D002492 | Central Nervous System Depressants |
MeSH PA | D018494 | Histamine Agents |
MeSH PA | D006633 | Histamine Antagonists |
MeSH PA | D006634 | Histamine H1 Antagonists |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D011619 | Psychotropic Drugs |
MeSH PA | D058830 | Serotonin 5-HT2 Receptor Antagonists |
MeSH PA | D058831 | Serotonin 5-HT3 Receptor Antagonists |
MeSH PA | D018490 | Serotonin Agents |
MeSH PA | D012702 | Serotonin Antagonists |
MeSH PA | D014149 | Tranquilizing Agents |
CHEBI has role | CHEBI:35474 | anti-anxiety agents |
CHEBI has role | CHEBI:37890 | alpha-adrenergic receptor blockaders |
CHEBI has role | CHEBI:37955 | H1 receptor antagonists |
CHEBI has role | CHEBI:37956 | antihistamines |
CHEBI has role | CHEBI:48279 | serotonin antagonists |
CHEBI has role | CHEBI:146270 | oneirogens |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Major depressive disorder | indication | 370143000 | |
Excessive vomiting in pregnancy | off-label use | 14094001 | |
Posttraumatic stress disorder | off-label use | 47505003 | DOID:2055 |
Suicidal thoughts | contraindication | 6471006 | |
Weight gain finding | contraindication | 8943002 | |
Hypercholesterolemia | contraindication | 13644009 | |
Myocardial infarction | contraindication | 22298006 | DOID:5844 |
Hypovolemia | contraindication | 28560003 | |
Orthostatic hypotension | contraindication | 28651003 | |
Dehydration | contraindication | 34095006 | |
Low blood pressure | contraindication | 45007003 | |
Cerebrovascular disease | contraindication | 62914000 | DOID:6713 |
Hyponatremia | contraindication | 89627008 | |
Seizure disorder | contraindication | 128613002 | |
Liver function tests abnormal | contraindication | 166603001 | |
Bipolar affective disorder, current episode manic | contraindication | 191618007 | |
Angina pectoris | contraindication | 194828000 | |
Impaired renal function disorder | contraindication | 197663003 | |
Cerebrovascular accident | contraindication | 230690007 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Akathisia | contraindication | 285145004 | |
Hypertriglyceridemia | contraindication | 302870006 | |
Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
Serotonin syndrome | contraindication | 371089000 | |
Obesity | contraindication | 414916001 | DOID:9970 |
Acute Thromboembolic Stroke | contraindication |
Species | Use | Relation |
---|---|---|
Cats | Management of weight loss in cats | Indication |
Product | Applicant | Ingredients |
---|---|---|
Mirataz | Dechra, Ltd. | 1 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 8.67 | Basic |
pKa2 | 2.91 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
5-hydroxytryptamine receptor 2C | GPCR | ANTAGONIST | Ki | 7.41 | CHEMBL | CHEMBL | |||
5-hydroxytryptamine receptor 2A | GPCR | ANTAGONIST | Ki | 7.16 | CHEMBL | CHEMBL | |||
Alpha-2A adrenergic receptor | GPCR | ANTAGONIST | Ki | 7.70 | CHEMBL | ||||
Sodium-dependent noradrenaline transporter | Transporter | Ki | 5.34 | PDSP | |||||
5-hydroxytryptamine receptor 1A | GPCR | Kd | 5.30 | CHEMBL | |||||
5-hydroxytryptamine receptor 7 | GPCR | Ki | 6.58 | CHEMBL | |||||
Alpha-1A adrenergic receptor | GPCR | IC50 | 5.50 | CHEMBL | |||||
Alpha-2B adrenergic receptor | GPCR | ANTAGONIST | IC50 | 6.65 | CHEMBL | ||||
D(3) dopamine receptor | GPCR | Ki | 5.24 | CHEMBL | |||||
Histamine H1 receptor | GPCR | Ki | 8.80 | WOMBAT-PK | |||||
Muscarinic acetylcholine receptor M1 | GPCR | WOMBAT-PK | |||||||
Muscarinic acetylcholine receptor M2 | GPCR | WOMBAT-PK | |||||||
Alpha-2C adrenergic receptor | GPCR | ANTAGONIST | Ki | 7.74 | CHEMBL | ||||
5-hydroxytryptamine receptor 3A | Ion channel | Ki | 5.54 | CHEMBL | |||||
D(1A) dopamine receptor | GPCR | Ki | 5.38 | PDSP | |||||
D(2) dopamine receptor | GPCR | Ki | 5.26 | PDSP | |||||
D(2) dopamine receptor | GPCR | Ki | 5.84 | CHEMBL | |||||
5-hydroxytryptamine receptor 2A | GPCR | Ki | 8.70 | CHEMBL | |||||
Transporter | Transporter | Ki | 5.79 | CHEMBL | |||||
D(1A) dopamine receptor | GPCR | Ki | 5.38 | CHEMBL | |||||
5-hydroxytryptamine receptor 2C | GPCR | Ki | 8.26 | CHEMBL | |||||
Adrenergic receptor alpha-1 | GPCR | Ki | 6.22 | CHEMBL |
ID | Source |
---|---|
4020978 | VUID |
N0000148449 | NUI |
D00563 | KEGG_DRUG |
4020978 | VANDF |
C0049506 | UMLSCUI |
CHEBI:6950 | CHEBI |
CHEMBL654 | ChEMBL_ID |
DB00370 | DRUGBANK_ID |
D000078785 | MESH_DESCRIPTOR_UI |
4205 | PUBCHEM_CID |
7241 | IUPHAR_LIGAND_ID |
6481 | INN_ID |
A051Q2099Q | UNII |
15996 | RXNORM |
46110 | MMSL |
5120 | MMSL |
d04025 | MMSL |
006054 | NDDF |
108430001 | SNOMEDCT_US |
386847004 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
REMERON | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0052-0105 | TABLET, FILM COATED | 15 mg | ORAL | NDA | 31 sections |
REMERONSOLTAB | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0052-0106 | TABLET, ORALLY DISINTEGRATING | 15 mg | ORAL | NDA | 31 sections |
REMERON | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0052-0107 | TABLET, FILM COATED | 30 mg | ORAL | NDA | 31 sections |
REMERONSOLTAB | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0052-0108 | TABLET, ORALLY DISINTEGRATING | 30 mg | ORAL | NDA | 31 sections |
REMERON | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0052-0109 | TABLET, FILM COATED | 45 mg | ORAL | NDA | 31 sections |
REMERONSOLTAB | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0052-0110 | TABLET, ORALLY DISINTEGRATING | 45 mg | ORAL | NDA | 31 sections |
REMERON | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0052-4364 | TABLET, FILM COATED | 15 mg | ORAL | NDA | 31 sections |
REMERON | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0052-4365 | TABLET, FILM COATED | 30 mg | ORAL | NDA | 31 sections |
Mirtazapine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-3515 | TABLET, FILM COATED | 15 mg | ORAL | ANDA | 29 sections |
Mirtazapine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-3515 | TABLET, FILM COATED | 15 mg | ORAL | ANDA | 29 sections |
Mirtazapine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-3530 | TABLET, FILM COATED | 30 mg | ORAL | ANDA | 29 sections |
Mirtazapine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-3530 | TABLET, FILM COATED | 30 mg | ORAL | ANDA | 29 sections |
Mirtazapine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-3545 | TABLET, FILM COATED | 45 mg | ORAL | ANDA | 29 sections |
Mirtazapine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-3545 | TABLET, FILM COATED | 45 mg | ORAL | ANDA | 29 sections |
Mirtazapine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8078 | TABLET | 7.50 mg | ORAL | ANDA | 25 sections |
Mirtazapine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8268 | TABLET, FILM COATED | 15 mg | ORAL | ANDA | 25 sections |
Mirtazapine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8269 | TABLET, FILM COATED | 30 mg | ORAL | ANDA | 25 sections |
Mirtazapine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6519 | TABLET, FILM COATED | 15 mg | ORAL | ANDA | 25 sections |
Mirtazapine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6519 | TABLET, FILM COATED | 15 mg | ORAL | ANDA | 25 sections |
Mirtazapine | Human Prescription Drug Label | 1 | 13107-001 | TABLET, FILM COATED | 7.50 mg | ORAL | ANDA | 28 sections |
Mirtazapine | Human Prescription Drug Label | 1 | 13107-001 | TABLET, FILM COATED | 7.50 mg | ORAL | ANDA | 28 sections |
Mirtazapine | Human Prescription Drug Label | 1 | 13107-003 | TABLET, FILM COATED | 30 mg | ORAL | ANDA | 28 sections |
Mirtazapine | Human Prescription Drug Label | 1 | 13107-003 | TABLET, FILM COATED | 30 mg | ORAL | ANDA | 28 sections |
Mirtazapine | Human Prescription Drug Label | 1 | 13107-031 | TABLET, FILM COATED | 15 mg | ORAL | ANDA | 28 sections |
Mirtazapine | Human Prescription Drug Label | 1 | 13107-031 | TABLET, FILM COATED | 15 mg | ORAL | ANDA | 28 sections |
Mirtazapine | Human Prescription Drug Label | 1 | 13107-032 | TABLET, FILM COATED | 45 mg | ORAL | ANDA | 28 sections |
Mirtazapine | Human Prescription Drug Label | 1 | 13107-032 | TABLET, FILM COATED | 45 mg | ORAL | ANDA | 28 sections |
MIRTAZAPINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-153 | TABLET, FILM COATED | 15 mg | ORAL | ANDA | 26 sections |
MIRTAZAPINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-154 | TABLET, FILM COATED | 30 mg | ORAL | ANDA | 26 sections |
MIRTAZAPINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-155 | TABLET, FILM COATED | 45 mg | ORAL | ANDA | 26 sections |