methyprylon 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	1774	125-64-4

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

methyprylon
dimerin
methyprylone
noctan
noludar
metiprilone

Molecular weight: 183.25
Formula: C10H17NO2
CLOGP: 1.78
LIPINSKI: 0
HAC: 3
HDO: 1
TPSA: 46.17
ALOGS: -1.21
ROTB: 2

Status: OFM

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
0.20	g	O

ADMET properties:

Property	Value	Reference
MRTD (Maximum Recommended Therapeutic Daily Dose)	36.40 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

Date	Agency	Company	Orphan
None	FDA	ROCHE

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	N05CE02	NERVOUS SYSTEM PSYCHOLEPTICS HYPNOTICS AND SEDATIVES Piperidinedione derivatives

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Insomnia	indication	193462001

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	12.01	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
GABA-A receptor alpha-1/beta-3/gamma-2	Ion channel	P14867 P18507 P28472	GBRA1_HUMAN GBRG2_HUMAN GBRB3_HUMAN	POSITIVE ALLOSTERIC MODULATOR				WOMBAT-PK	CHEMBL

External reference:

ID	Source
4017769	VUID
N0000146133	NUI
D01150	KEGG_DRUG
4017769	VANDF
C0025840	UMLSCUI
CHEBI:31837	CHEBI
CHEMBL1200790	ChEMBL_ID
DB01107	DRUGBANK_ID
4162	PUBCHEM_CID
287	INN_ID
C084583	MESH_SUPPLEMENTAL_RECORD_UI
7238	IUPHAR_LIGAND_ID
CUT48I42ON	UNII
204352	RXNORM
001433	NDDF
30964009	SNOMEDCT_US
387169003	SNOMEDCT_US

Pharmaceutical products:

None