methylprednisolone Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
prednisone and prednisolone derivatives 1768 83-43-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • methylprednisolone
  • medralone
  • metilbetasone
A PREDNISOLONE derivative with similar anti-inflammatory action.
  • Molecular weight: 374.48
  • Formula: C22H30O5
  • CLOGP: 1.74
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 3
  • TPSA: 94.83
  • ALOGS: -3.54
  • ROTB: 2

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
7.50 mg O
20 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.32 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 4.90 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 11.14 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 82 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 1.20 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 6.10 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.23 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2.30 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Oct. 24, 1957 FDA PHARMACIA AND UPJOHN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cytomegalovirus infection 694.54 9.44 520 152703 19019 53176824
Product use in unapproved indication 434.25 9.44 981 152242 111308 53084535
Infusion related reaction 431.34 9.44 1199 152024 154758 53041085
Completed suicide 339.96 9.44 13 153210 138188 53057655
Transplant rejection 286.82 9.44 236 152987 9915 53185928
Death 264.98 9.44 385 152838 356847 52838996
Off label use 247.35 9.44 2249 150974 469963 52725880
Posterior reversible encephalopathy syndrome 236.30 9.44 261 152962 15899 53179944
Glossodynia 228.96 9.44 15 153208 100276 53095567
Aspergillus infection 213.30 9.44 175 153048 7321 53188522
Blood pressure fluctuation 202.90 9.44 365 152858 35105 53160738
Kidney transplant rejection 201.88 9.44 135 153088 4109 53191734
Blood pressure diastolic abnormal 199.69 9.44 180 153043 8565 53187278
Haemophagocytic lymphohistiocytosis 191.00 9.44 179 153044 8958 53186885
Polyomavirus-associated nephropathy 188.66 9.44 93 153130 1556 53194287
Pemphigus 182.65 9.44 38 153185 103993 53091850
Urine abnormality 182.11 9.44 150 153073 6310 53189533
Drug ineffective for unapproved indication 181.55 9.44 259 152964 20461 53175382
Bronchopulmonary aspergillosis 170.18 9.44 164 153059 8501 53187342
Oxygen saturation decreased 165.60 9.44 541 152682 76184 53119659
Abdominal discomfort 162.92 9.44 239 152984 220823 52975020
Thrombotic microangiopathy 161.67 9.44 165 153058 9172 53186671
BK virus infection 157.14 9.44 103 153120 3029 53192814
Multiple organ dysfunction syndrome 154.51 9.44 429 152794 55248 53140595
Cytomegalovirus infection reactivation 153.46 9.44 94 153129 2450 53193393
Blood pressure systolic abnormal 151.42 9.44 141 153082 6998 53188845
Product dose omission issue 151.37 9.44 197 153026 191423 53004420
Toxicity to various agents 150.76 9.44 249 152974 219349 52976494
Alopecia 149.28 9.44 279 152944 234304 52961539
Red blood cells urine positive 148.76 9.44 97 153126 2827 53193016
Complications of transplanted kidney 148.05 9.44 90 153133 2313 53193530
Pneumocystis jirovecii pneumonia 146.84 9.44 207 153016 16171 53179672
Nocardiosis 144.93 9.44 83 153140 1904 53193939
Lymphocyte count decreased 144.53 9.44 276 152947 27776 53168067
Pseudomonas infection 143.17 9.44 163 153060 10265 53185578
Epstein-Barr virus infection 143.05 9.44 139 153084 7279 53188564
Mucormycosis 139.04 9.44 89 153134 2511 53193332
Fall 137.34 9.44 547 152676 357893 52837950
Enterococcal infection 129.25 9.44 133 153090 7465 53188378
Urine leukocyte esterase positive 129.19 9.44 89 153134 2847 53192996
Throat irritation 128.10 9.44 282 152941 31399 53164444
Varicella zoster virus infection 123.04 9.44 82 153141 2481 53193362
White blood cells urine positive 122.84 9.44 103 153120 4442 53191401
Cytomegalovirus viraemia 122.45 9.44 107 153116 4884 53190959
Contraindicated product administered 120.43 9.44 127 153096 135502 53060341
Klebsiella infection 119.31 9.44 130 153093 7796 53188047
Blood pressure increased 118.84 9.44 750 152473 139729 53056114
Graft versus host disease 118.15 9.44 123 153100 6999 53188844
Urinary sediment present 116.56 9.44 73 153150 1981 53193862
Wound 115.92 9.44 59 153164 91498 53104345
Delayed graft function 115.29 9.44 57 153166 960 53194883
Hand deformity 114.62 9.44 50 153173 84799 53111044
Swelling 110.65 9.44 240 152983 190865 53004978
Confusional state 109.92 9.44 247 152976 193974 53001869
Drug intolerance 104.74 9.44 276 152947 205217 52990626
Post transplant lymphoproliferative disorder 103.82 9.44 92 153131 4279 53191564
Acinetobacter infection 102.24 9.44 60 153163 1443 53194400
Steroid diabetes 101.68 9.44 51 153172 887 53194956
Respiratory failure 101.32 9.44 562 152661 99950 53095893
Intentional overdose 100.06 9.44 34 153189 67171 53128672
Heart rate decreased 99.84 9.44 282 152941 36665 53159178
Lymphopenia 99.73 9.44 176 153047 16667 53179176
Discomfort 97.02 9.44 79 153144 95393 53100450
Injection site pain 96.43 9.44 110 153113 113281 53082562
Infective aneurysm 95.26 9.44 39 153184 410 53195433
Cushingoid 94.78 9.44 110 153113 7072 53188771
Adenovirus infection 94.58 9.44 77 153146 3185 53192658
Erythema 94.42 9.44 772 152451 156197 53039646
Wrong technique in product usage process 93.59 9.44 28 153195 60004 53135839
Septic shock 93.19 9.44 390 152833 61839 53134004
Reversible cerebral vasoconstriction syndrome 91.65 9.44 65 153158 2180 53193663
Crystal urine present 90.76 9.44 55 153168 1405 53194438
Arthropathy 89.22 9.44 169 153054 141284 53054559
Blood pressure diastolic decreased 88.62 9.44 167 153056 16636 53179207
Acute graft versus host disease in skin 87.84 9.44 74 153149 3212 53192631
Pericarditis 86.91 9.44 38 153185 64368 53131475
Cardiac failure congestive 86.72 9.44 83 153140 92674 53103169
Drug abuse 86.32 9.44 40 153183 65486 53130357
Progressive multifocal leukoencephalopathy 85.47 9.44 137 153086 11992 53183851
Liver transplant rejection 83.75 9.44 52 153171 1389 53194454
Encephalitis autoimmune 83.61 9.44 50 153173 1246 53194597
Electric shock 82.90 9.44 46 153177 991 53194852
Rheumatoid factor positive 81.23 9.44 11 153212 41187 53154656
Systemic lupus erythematosus 80.71 9.44 148 153075 125266 53070577
Irritable bowel syndrome 80.67 9.44 14 153209 43618 53152225
Intervertebral discitis 80.63 9.44 66 153157 2751 53193092
Synovitis 80.02 9.44 116 153107 107777 53088066
Blood pressure systolic increased 78.52 9.44 251 152972 34926 53160917
Hospitalisation 78.27 9.44 54 153169 70958 53124885
Cytomegalovirus test positive 78.26 9.44 66 153157 2869 53192974
Chorioretinopathy 77.99 9.44 42 153181 851 53194992
Pneumomediastinum 77.21 9.44 48 153175 1285 53194558
Lupus nephritis 76.72 9.44 61 153162 2438 53193405
Acute graft versus host disease in intestine 76.72 9.44 53 153170 1703 53194140
Nausea 76.10 9.44 1626 151597 754465 52441378
Fatigue 75.56 9.44 1564 151659 728942 52466901
Graft versus host disease in gastrointestinal tract 75.47 9.44 65 153158 2909 53192934
Disease recurrence 75.30 9.44 178 153045 20768 53175075
Heart rate increased 73.65 9.44 446 152777 81869 53113974
Acute respiratory distress syndrome 73.00 9.44 188 153035 23144 53172699
Duodenal ulcer perforation 72.79 9.44 8 153215 35175 53160668
Escherichia infection 72.75 9.44 127 153096 11923 53183920
Device expulsion 72.59 9.44 3 153220 29810 53166033
Blood urine present 72.51 9.44 134 153089 13151 53182692
Diarrhoea 72.33 9.44 1314 151909 624232 52571611
Myopathy 70.39 9.44 111 153112 9581 53186262
Viral haemorrhagic cystitis 70.28 9.44 37 153186 715 53195128
Ureaplasma infection 70.22 9.44 34 153189 546 53195297
Bacterial test 69.57 9.44 44 153179 1215 53194628
Dehydration 69.54 9.44 249 152974 168161 53027682
Vomiting 69.44 9.44 1008 152215 496131 52699712
Thrombocytopenia 68.75 9.44 654 152569 138073 53057770
Immunosuppressant drug level increased 67.10 9.44 65 153158 3390 53192453
Human herpesvirus 6 infection 65.63 9.44 56 153167 2474 53193369
Cytomegalovirus chorioretinitis 65.60 9.44 47 153176 1602 53194241
Helicobacter infection 65.08 9.44 16 153207 39053 53156790
Drug ineffective 64.14 9.44 2912 150311 814333 52381510
Anti-cyclic citrullinated peptide antibody positive 63.64 9.44 43 153180 57129 53138714
Overdose 63.39 9.44 134 153089 107602 53088241
Systemic candida 62.19 9.44 59 153164 2998 53192845
Urine ketone body present 62.12 9.44 53 153170 2341 53193502
COVID-19 60.63 9.44 238 152985 36650 53159193
Drug resistance 60.55 9.44 159 153064 19803 53176040
Nephrotic syndrome 59.34 9.44 75 153148 5270 53190573
Human herpesvirus 8 infection 59.32 9.44 23 153200 207 53195636
Suicide attempt 59.25 9.44 48 153175 58120 53137723
Candida infection 58.85 9.44 183 153040 25090 53170753
Red cell distribution width increased 58.79 9.44 98 153125 8862 53186981
COVID-19 pneumonia 58.67 9.44 87 153136 7116 53188727
Muscle injury 58.56 9.44 8 153215 29758 53166085
Acute graft versus host disease 58.44 9.44 67 153156 4250 53191593
Adverse drug reaction 57.48 9.44 42 153181 53583 53142260
Cytomegalovirus colitis 57.34 9.44 47 153176 1963 53193880
Premature delivery 57.11 9.44 185 153038 25919 53169924
Osteonecrosis 56.94 9.44 187 153036 26388 53169455
Folliculitis 54.77 9.44 12 153211 31697 53164146
Mycoplasma infection 54.29 9.44 26 153197 407 53195436
Pneumonia cytomegaloviral 54.16 9.44 47 153176 2125 53193718
Immune thrombocytopenia 53.79 9.44 97 153126 9341 53186502
Pain 52.92 9.44 1287 151936 587111 52608732
Pyrexia 52.72 9.44 1523 151700 401670 52794173
Granulomatosis with polyangiitis 52.62 9.44 45 153178 1994 53193849
Sepsis 52.43 9.44 647 152576 145782 53050061
Loss of personal independence in daily activities 51.81 9.44 75 153148 69740 53126103
Product use issue 51.43 9.44 216 153007 139368 53056475
Haemoglobin urine present 51.29 9.44 31 153192 788 53195055
Acute graft versus host disease in liver 51.12 9.44 29 153194 653 53195190
Constipation 50.89 9.44 347 152876 198065 52997778
Dizziness 50.77 9.44 758 152465 371501 52824342
Leukopenia 50.60 9.44 373 152850 73090 53122753
Demyelination 50.41 9.44 75 153148 6152 53189691
Inappropriate schedule of product administration 50.29 9.44 86 153137 74792 53121051
Status epilepticus 50.26 9.44 125 153098 15059 53180784
Injection site erythema 49.82 9.44 91 153132 77158 53118685
Adverse event 49.70 9.44 28 153195 41033 53154810
Pneumatosis intestinalis 48.87 9.44 45 153178 2201 53193642
Immunodeficiency 48.27 9.44 122 153101 14845 53180998
Temperature regulation disorder 48.24 9.44 60 153163 4147 53191696
Urine analysis abnormal 48.15 9.44 62 153161 4438 53191405
Product quality issue 48.14 9.44 23 153200 37000 53158843
Staphylococcal sepsis 47.81 9.44 83 153140 7757 53188086
Renal transplant failure 47.69 9.44 28 153195 674 53195169
Serotonin syndrome 47.67 9.44 9 153214 26397 53169446
Culture urine positive 47.58 9.44 55 153168 3520 53192323
Peripheral swelling 47.31 9.44 372 152851 205736 52990107
Lymphocyte percentage decreased 46.69 9.44 49 153174 2814 53193029
Knee arthroplasty 46.57 9.44 19 153204 33550 53162293
Neutrophil count increased 46.49 9.44 122 153101 15188 53180655
Graft versus host disease in skin 46.14 9.44 47 153176 2606 53193237
Intensive care unit acquired weakness 45.84 9.44 28 153195 726 53195117
Strongyloidiasis 45.76 9.44 31 153192 964 53194879
Myocardial infarction 45.73 9.44 140 153083 99214 53096629
Glomerulonephritis 45.43 9.44 38 153185 1633 53194210
Stomatitis 45.40 9.44 138 153085 98020 53097823
Monocyte count increased 45.35 9.44 68 153155 5617 53190226
Brain abscess 44.40 9.44 40 153183 1901 53193942
Protein urine present 44.21 9.44 67 153156 5587 53190256
Listeriosis 44.17 9.44 35 153188 1392 53194451
Mycobacterium abscessus infection 43.44 9.44 26 153197 649 53195194
Vasculitis 43.29 9.44 117 153106 14823 53181020
Cystitis haemorrhagic 43.24 9.44 55 153168 3889 53191954
Blood pressure diastolic increased 42.89 9.44 75 153148 7049 53188794
Accidental exposure to product 42.89 9.44 8 153215 23666 53172177
Decreased appetite 42.65 9.44 403 152820 214571 52981272
Pulmonary alveolar haemorrhage 42.51 9.44 58 153165 4392 53191451
Psoriasis 42.05 9.44 120 153103 86969 53108874
Adrenal insufficiency 41.84 9.44 115 153108 14714 53181129
Central nervous system infection 41.82 9.44 26 153197 696 53195147
Ear pruritus 41.57 9.44 43 153180 2428 53193415
Neutrophil percentage increased 41.39 9.44 46 153177 2820 53193023
Proteinuria 41.30 9.44 130 153093 17938 53177905
Hyponatraemia 41.29 9.44 166 153057 108441 53087402
Herpes simplex 40.98 9.44 77 153146 7652 53188191
Chronic allograft nephropathy 40.66 9.44 25 153198 656 53195187
Infection reactivation 40.31 9.44 29 153194 995 53194848
Chronic graft versus host disease 40.20 9.44 48 153175 3180 53192663
International normalised ratio increased 39.86 9.44 47 153176 47714 53148129
Herpes zoster 39.17 9.44 354 152869 73665 53122178
Epstein-Barr virus associated lymphoproliferative disorder 39.00 9.44 35 153188 1655 53194188
Therapy non-responder 38.87 9.44 258 152965 48862 53146981
Oedema peripheral 38.83 9.44 309 152914 170478 53025365
Bacterial test positive 38.62 9.44 59 153164 4954 53190889
Febrile bone marrow aplasia 38.59 9.44 72 153151 7117 53188726
Cerebrovascular accident 38.58 9.44 163 153060 105011 53090832
Opportunistic infection 38.30 9.44 36 153187 1808 53194035
Pleocytosis 38.15 9.44 23 153200 582 53195261
Hypogammaglobulinaemia 38.14 9.44 65 153158 5985 53189858
Alveolitis 38.10 9.44 43 153180 2681 53193162
Disseminated intravascular coagulation 38.06 9.44 134 153089 19585 53176258
Depressed level of consciousness 37.95 9.44 61 153162 54367 53141476
Feeding intolerance 37.86 9.44 22 153201 519 53195324
Polyomavirus viraemia 37.86 9.44 21 153202 452 53195391
Nephropathy toxic 37.74 9.44 79 153144 8493 53187350
Necrotising herpetic retinopathy 37.64 9.44 13 153210 81 53195762
Hypoglycaemia 37.62 9.44 70 153153 58943 53136900
Pedal pulse abnormal 37.39 9.44 15 153208 149 53195694
Intentional product use issue 36.99 9.44 344 152879 72150 53123693
Dermatomyositis 36.97 9.44 40 153183 2379 53193464
Lung abscess 36.92 9.44 34 153189 1663 53194180
Disseminated tuberculosis 36.53 9.44 43 153180 2806 53193037
Herpes virus infection 36.28 9.44 58 153165 5065 53190778
Transplant failure 36.08 9.44 32 153191 1490 53194353
Encephalitis 35.89 9.44 74 153149 7870 53187973
Incorrect dose administered 35.78 9.44 57 153166 50988 53144855
Symptom masked 35.68 9.44 23 153200 657 53195186
Enterobacter infection 35.58 9.44 36 153187 1980 53193863
Q fever 35.26 9.44 12 153211 71 53195772
Staphylococcal infection 35.18 9.44 210 153013 38338 53157505
Multiple sclerosis relapse 35.13 9.44 235 152988 44618 53151225
C-reactive protein increased 35.07 9.44 323 152900 67563 53128280
Orthostatic hypotension 34.99 9.44 21 153202 29732 53166111
Plasma cell myeloma 34.96 9.44 52 153171 47822 53148021
Segmental diverticular colitis 34.90 9.44 14 153209 139 53195704
Sedation 34.83 9.44 21 153202 29654 53166189
Pharyngeal paraesthesia 34.41 9.44 30 153193 1365 53194478
Stenotrophomonas infection 34.36 9.44 33 153190 1703 53194140
Encephalitis cytomegalovirus 34.09 9.44 21 153202 553 53195290
Flushing 34.03 9.44 331 152892 70269 53125574
Necrotising retinitis 34.03 9.44 17 153206 293 53195550
Cytomegalovirus enterocolitis 33.92 9.44 22 153201 635 53195208
JC virus infection 32.78 9.44 33 153190 1804 53194039
Calcium ionised decreased 32.71 9.44 16 153207 263 53195580
Gastroenteritis rotavirus 32.68 9.44 13 153210 126 53195717
Pneumocystis jirovecii infection 32.37 9.44 29 153194 1368 53194475
Laryngeal stenosis 32.13 9.44 23 153200 783 53195060
Cerebral aspergillosis 32.02 9.44 18 153205 398 53195445
Thunderclap headache 31.76 9.44 14 153209 179 53195664
Blister 31.44 9.44 118 153105 78635 53117208
Quadriparesis 31.40 9.44 33 153190 1898 53193945
Bacteraemia 31.17 9.44 107 153116 15442 53180401
Viraemia 31.15 9.44 26 153197 1114 53194729
Intentional self-injury 30.94 9.44 17 153206 25267 53170576
Shock haemorrhagic 30.82 9.44 76 153147 9107 53186736
Central nervous system lymphoma 30.64 9.44 29 153194 1469 53194374
Hypofibrinogenaemia 30.46 9.44 26 153197 1149 53194694
Choroiditis 30.30 9.44 13 153210 155 53195688
Partial seizures 30.29 9.44 55 153168 5325 53190518
Systemic mycosis 30.03 9.44 25 153198 1067 53194776
Post-traumatic stress disorder 29.84 9.44 51 153172 4707 53191136
Lower respiratory tract infection 29.79 9.44 147 153076 90834 53105009
West Nile viral infection 29.68 9.44 17 153206 390 53195453
Diabetes mellitus 29.66 9.44 260 152963 53639 53142204
Nitrite urine present 29.59 9.44 23 153200 889 53194954
Human bocavirus infection 29.59 9.44 16 153207 327 53195516
Hyperammonaemia 29.45 9.44 53 153170 5096 53190747
Intentional product misuse 29.40 9.44 61 153162 49331 53146512
Gastroenteritis norovirus 29.40 9.44 30 153193 1667 53194176
Injection site bruising 29.37 9.44 39 153184 37607 53158236
Rhodococcus infection 29.18 9.44 11 153212 91 53195752
Respiratory rate increased 29.14 9.44 90 153133 12293 53183550
Malaise 28.64 9.44 795 152428 356822 52839021
Feeling hot 28.63 9.44 211 153012 41333 53154510
Accidental overdose 28.45 9.44 13 153210 21466 53174377
Rebound effect 28.19 9.44 40 153183 3143 53192700
Intestinal perforation 27.98 9.44 84 153139 11296 53184547
Anti-thyroid antibody positive 27.72 9.44 17 153206 444 53195399
Chronic graft versus host disease in skin 27.65 9.44 20 153203 692 53195151
Factor XIII deficiency 27.49 9.44 10 153213 74 53195769
Proteus infection 27.46 9.44 22 153201 889 53194954
Leukoencephalopathy 27.45 9.44 46 153177 4178 53191665
Malignant neoplasm progression 27.40 9.44 109 153114 71432 53124411
Immunosuppressant drug level decreased 27.39 9.44 23 153200 994 53194849
Neuromyelitis optica spectrum disorder 27.39 9.44 23 153200 994 53194849
Injection site reaction 27.35 9.44 67 153156 51099 53144744
Hyperglycaemia 27.29 9.44 203 153020 39881 53155962
Blood thyroid stimulating hormone decreased 27.17 9.44 47 153176 4380 53191463
Diffuse alveolar damage 27.10 9.44 22 153201 906 53194937
Pancytopenia 26.81 9.44 388 152835 90540 53105303
Birdshot chorioretinopathy 26.81 9.44 10 153213 80 53195763
Epstein-Barr virus infection reactivation 26.73 9.44 17 153206 474 53195369
Malacoplakia vesicae 26.63 9.44 9 153214 52 53195791
Cataract 26.60 9.44 238 152985 49382 53146461
Food allergy 26.51 9.44 67 153156 8151 53187692
Pulmonary tuberculosis 26.34 9.44 49 153174 4832 53191011
Hypertension 26.27 9.44 840 152383 224591 52971252
Multiple-drug resistance 26.24 9.44 39 153184 3196 53192647
Mean cell haemoglobin decreased 26.20 9.44 40 153183 3357 53192486
Product prescribing error 26.06 9.44 17 153206 23014 53172829
Therapeutic product effect decreased 26.00 9.44 233 152990 125422 53070421
Lethargy 26.00 9.44 74 153149 53686 53142157
Graft versus host disease in liver 25.84 9.44 17 153206 503 53195340
Cytomegalovirus gastrointestinal infection 25.81 9.44 14 153209 288 53195555
Device malfunction 25.56 9.44 7 153216 15901 53179942
C-reactive protein abnormal 25.53 9.44 22 153201 25848 53169995
Red blood cell count increased 25.53 9.44 35 153188 2662 53193181
Rhabdomyolysis 25.51 9.44 55 153168 43868 53151975
Cytomegalovirus enteritis 25.47 9.44 13 153210 235 53195608
Cerebral artery stenosis 25.45 9.44 16 153207 437 53195406
Malacoplakia gastrointestinal 25.41 9.44 9 153214 61 53195782
Hepatic necrosis 25.32 9.44 53 153170 5697 53190146
Gastrointestinal disorder 25.29 9.44 153 153070 89851 53105992
Pyomyositis 25.26 9.44 15 153208 369 53195474
B-lymphocyte count decreased 25.23 9.44 21 153202 896 53194947
Specific gravity urine decreased 25.21 9.44 18 153205 610 53195233
Escherichia urinary tract infection 25.18 9.44 80 153143 11093 53184750
Quadriplegia 25.18 9.44 29 153194 1849 53193994
Rubella antibody positive 25.17 9.44 9 153214 63 53195780
Oral herpes 25.16 9.44 124 153099 21055 53174788
Band sensation 25.14 9.44 19 153204 704 53195139
Injection site swelling 25.07 9.44 53 153170 42575 53153268
Contusion 24.85 9.44 201 153022 110531 53085312
Red blood cells urine 24.73 9.44 16 153207 460 53195383
Focal segmental glomerulosclerosis 24.69 9.44 26 153197 1499 53194344
Blood calcium decreased 24.68 9.44 13 153210 19781 53176062
Smear cervix abnormal 24.65 9.44 35 153188 2751 53193092
Device dislocation 24.62 9.44 19 153204 23578 53172265
Chronic graft versus host disease in liver 24.61 9.44 13 153210 253 53195590
Hypophagia 24.41 9.44 32 153191 31030 53164813
Renal tubular atrophy 24.34 9.44 17 153206 556 53195287
IgA nephropathy 24.15 9.44 16 153207 479 53195364
Hallucination 23.96 9.44 77 153146 53761 53142082
Interleukin-2 receptor increased 23.92 9.44 9 153214 74 53195769
Intra-abdominal pressure increased 23.86 9.44 12 153211 210 53195633
Urinary tract infection bacterial 23.83 9.44 45 153178 4489 53191354
Blood glucose decreased 23.72 9.44 14 153209 20002 53175841
Hip arthroplasty 23.70 9.44 27 153196 27835 53168008
Sleep disorder 23.63 9.44 88 153135 58782 53137061
Atrial fibrillation 23.55 9.44 206 153017 111446 53084397
Kaposi's sarcoma 23.51 9.44 11 153212 163 53195680
Hepatitis B 23.47 9.44 41 153182 3851 53191992
Muir-Torre syndrome 23.42 9.44 7 153216 25 53195818
CSF protein increased 23.41 9.44 16 153207 505 53195338
Pneumonia klebsiella 23.39 9.44 30 153193 2139 53193704
Steroid dependence 23.31 9.44 13 153210 283 53195560
Tuberculosis gastrointestinal 23.19 9.44 14 153209 355 53195488
Gastrointestinal mucormycosis 23.12 9.44 12 153211 225 53195618
Klebsiella test positive 23.07 9.44 21 153202 1012 53194831
Gastrooesophageal reflux disease 22.98 9.44 141 153082 82522 53113321
Pulmonary haemorrhage 22.87 9.44 57 153166 6876 53188967
Myelitis 22.84 9.44 23 153200 1258 53194585
Optic neuritis 22.83 9.44 59 153164 7276 53188567
Meningoencephalitis viral 22.75 9.44 14 153209 368 53195475
Gastropleural fistula 22.75 9.44 8 153215 53 53195790
Complication associated with device 22.67 9.44 9 153214 16156 53179687
Injection site pruritus 22.59 9.44 54 153169 41535 53154308
Pulmonary nocardiosis 22.48 9.44 11 153212 181 53195662
Chorioretinitis 22.41 9.44 14 153209 378 53195465
Pyelonephritis fungal 22.40 9.44 10 153213 132 53195711
Breast cancer metastatic 22.39 9.44 8 153215 15320 53180523
Memory impairment 22.31 9.44 147 153076 84610 53111233
CSF measles antibody positive 22.25 9.44 8 153215 57 53195786
Urinary tract candidiasis 22.14 9.44 16 153207 553 53195290
Pregnancy 22.14 9.44 35 153188 31406 53164437
Biloma 22.01 9.44 8 153215 59 53195784
Autoimmune hepatitis 21.99 9.44 63 153160 8255 53187588
Sense of oppression 21.84 9.44 21 153202 1085 53194758
Blood potassium increased 21.83 9.44 12 153211 17829 53178014
Blood brain barrier defect 21.78 9.44 9 153214 97 53195746
Syncope 21.73 9.44 211 153012 111782 53084061
Faecal volume decreased 21.69 9.44 11 153212 196 53195647
Disseminated varicella zoster vaccine virus infection 21.67 9.44 8 153215 62 53195781
Bacterial sepsis 21.67 9.44 40 153183 3922 53191921
Central nervous system viral infection 21.46 9.44 9 153214 101 53195742
Diffuse large B-cell lymphoma 21.36 9.44 54 153169 6571 53189272
Urticaria 21.32 9.44 526 152697 135359 53060484
Rash 21.29 9.44 1056 152167 445135 52750708
Tuberculosis 21.16 9.44 75 153148 10996 53184847
Glomerulosclerosis 21.11 9.44 13 153210 342 53195501
Escherichia sepsis 21.08 9.44 43 153180 4538 53191305
Unresponsive to stimuli 20.99 9.44 40 153183 33386 53162457
Obstructive airways disorder 20.92 9.44 12 153211 17417 53178426
Corynebacterium infection 20.91 9.44 14 153209 427 53195416
Clostridium difficile colitis 20.89 9.44 112 153111 19653 53176190
Bronchostenosis 20.85 9.44 14 153209 429 53195414
Joint tuberculosis 20.78 9.44 9 153214 110 53195733
Psoriatic arthropathy 20.70 9.44 70 153153 48120 53147723
Central nervous system vasculitis 20.69 9.44 19 153204 926 53194917
Device issue 20.68 9.44 19 153204 21639 53174204
Pathogen resistance 20.66 9.44 53 153170 6507 53189336
Meningoencephalitis bacterial 20.54 9.44 8 153215 73 53195770
Natural killer-cell leukaemia 20.49 9.44 9 153214 114 53195729
Staphylococcal bacteraemia 20.49 9.44 46 153177 5187 53190656
Mobility decreased 20.22 9.44 132 153091 76139 53119704
Haemolytic anaemia 20.20 9.44 71 153152 10368 53185475
Loss of consciousness 20.18 9.44 220 153003 113992 53081851
Thyroxine free increased 20.15 9.44 18 153205 846 53194997
Coronary artery disease 20.15 9.44 41 153182 33396 53162447
Aplasia 20.07 9.44 40 153183 4152 53191691
Swollen joint count increased 20.06 9.44 4 153219 11286 53184557
Cryptococcosis 19.90 9.44 19 153204 973 53194870
Temperature intolerance 19.88 9.44 60 153163 8093 53187750
Device difficult to use 19.87 9.44 3 153220 10356 53185487
Allergy test positive 19.84 9.44 13 153210 382 53195461
Pulmonary mucormycosis 19.82 9.44 9 153214 124 53195719
Bacillus infection 19.75 9.44 15 153208 560 53195283
Infective pulmonary exacerbation of cystic fibrosis 19.72 9.44 4 153219 11152 53184691
Hepatic cyst infection 19.69 9.44 9 153214 126 53195717
Full blood count decreased 19.67 9.44 24 153199 24005 53171838
Fibromyalgia 19.64 9.44 63 153160 44012 53151831
Liver abscess 19.61 9.44 32 153191 2843 53193000
Graft loss 19.60 9.44 13 153210 390 53195453
Hairy cell leukaemia 19.55 9.44 6 153217 24 53195819
Haemolytic uraemic syndrome 19.53 9.44 30 153193 2531 53193312
Joint effusion 19.44 9.44 83 153140 13269 53182574
Allergy to plants 19.43 9.44 15 153208 574 53195269
Growth retardation 19.41 9.44 20 153203 1124 53194719
Mean cell volume decreased 19.40 9.44 31 153192 2706 53193137
Aeromonas infection 19.38 9.44 8 153215 86 53195757
Pyelonephritis 19.36 9.44 96 153127 16341 53179502
Perinephric abscess 19.34 9.44 10 153213 186 53195657
Therapeutic response decreased 19.13 9.44 215 153008 47354 53148489
Anal erythema 19.10 9.44 10 153213 191 53195652
Pulmonary hypertension 18.99 9.44 50 153173 37220 53158623
Biliary anastomosis complication 18.98 9.44 6 153217 27 53195816
Bone pain 18.97 9.44 78 153145 50644 53145199
Product storage error 18.93 9.44 7 153216 13123 53182720
Listeria encephalitis 18.91 9.44 11 153212 260 53195583
Meningitis chemical 18.90 9.44 9 153214 139 53195704
Acute respiratory failure 18.89 9.44 154 153069 31104 53164739
Interleukin level increased 18.86 9.44 12 153211 335 53195508
Neuropsychiatric lupus 18.84 9.44 9 153214 140 53195703
Evans syndrome 18.82 9.44 10 153213 197 53195646
Swollen tongue 18.82 9.44 38 153185 31042 53164801
Pneumonia lipoid 18.79 9.44 9 153214 141 53195702
Fungaemia 18.75 9.44 27 153196 2150 53193693
Sebaceous carcinoma 18.64 9.44 6 153217 29 53195814
Therapeutic product effect incomplete 18.63 9.44 171 153052 91613 53104230
Unevaluable event 18.58 9.44 76 153147 49422 53146421
Drug level decreased 18.58 9.44 52 153171 6722 53189121
Red blood cell sedimentation rate abnormal 18.55 9.44 11 153212 15678 53180165
Hypersensitivity 18.49 9.44 462 152761 210203 52985640
Substance-induced psychotic disorder 18.47 9.44 24 153199 1733 53194110
Epstein-Barr viraemia 18.47 9.44 17 153206 831 53195012
Candida sepsis 18.47 9.44 22 153201 1454 53194389
Monocyte percentage increased 18.44 9.44 19 153204 1068 53194775
Hepatitis acute 18.44 9.44 62 153161 8854 53186989
Asthenia 18.41 9.44 803 152420 342787 52853056
Pulmonary arterial hypertension 18.34 9.44 31 153192 27091 53168752
Pneumatosis 18.30 9.44 13 153210 437 53195406
Coeliac disease 18.29 9.44 61 153162 8674 53187169
Cerebellar stroke 18.25 9.44 10 153213 210 53195633
Aphthous ulcer 18.24 9.44 71 153152 10887 53184956
Tachycardia 18.22 9.44 423 152800 107789 53088054
Urine oxalate increased 18.21 9.44 10 153213 211 53195632
Graft versus host disease in lung 18.04 9.44 12 153211 362 53195481
Secondary immunodeficiency 18.03 9.44 19 153204 1096 53194747
Interstitial lung disease 18.02 9.44 252 152971 58370 53137473
Band neutrophil percentage increased 18.00 9.44 10 153213 216 53195627
Hypertriglyceridaemia 17.89 9.44 49 153174 6255 53189588
Lichen sclerosus 17.88 9.44 18 153205 984 53194859
Oral pain 17.85 9.44 31 153192 26806 53169037
Eosinopenia 17.85 9.44 6 153217 34 53195809
Large intestine perforation 17.71 9.44 57 153166 7957 53187886
Penicillium infection 17.70 9.44 8 153215 109 53195734
Drug-induced liver injury 17.66 9.44 144 153079 29089 53166754
Therapy partial responder 17.59 9.44 48 153175 6115 53189728
Dyskinesia 17.56 9.44 41 153182 31792 53164051
Serum sickness 17.54 9.44 29 153194 2604 53193239
Hepatitis toxic 17.54 9.44 32 153191 3109 53192734
Schizophrenia 17.53 9.44 4 153219 10275 53185568
Feeling abnormal 17.53 9.44 278 152945 135023 53060820
Pain in jaw 17.52 9.44 59 153164 40610 53155233
Haemoglobin urine 17.50 9.44 8 153215 112 53195731
Enterococcus test positive 17.48 9.44 19 153204 1136 53194707
Pneumonia cryptococcal 17.48 9.44 15 153208 668 53195175
Globulins decreased 17.48 9.44 10 153213 229 53195614
Pain in extremity 17.44 9.44 656 152567 284394 52911449
Poisoning 17.41 9.44 9 153214 13841 53182002
Eye infection toxoplasmal 17.35 9.44 11 153212 305 53195538
Osteonecrosis of jaw 17.30 9.44 50 153173 36096 53159747
Engraftment syndrome 17.28 9.44 12 153211 389 53195454
Renal artery stenosis 17.24 9.44 24 153199 1852 53193991
Visceral leishmaniasis 17.24 9.44 13 153210 480 53195363
Cerebral venous thrombosis 17.24 9.44 27 153196 2317 53193526
Toxic neuropathy 17.22 9.44 12 153211 391 53195452
Serratia infection 17.17 9.44 17 153206 911 53194932
Chromoblastomycosis 17.15 9.44 5 153218 16 53195827
Lip pruritus 17.12 9.44 15 153208 687 53195156
Glomerulonephritis chronic 17.04 9.44 9 153214 175 53195668
Sputum discoloured 17.03 9.44 10 153213 14329 53181514
Torsade de pointes 17.03 9.44 8 153215 12997 53182846
Orbital apex syndrome 17.03 9.44 6 153217 40 53195803
Transient hypogammaglobulinaemia of infancy 16.90 9.44 6 153217 41 53195802
Nasal septum disorder 16.89 9.44 8 153215 122 53195721
Haematemesis 16.81 9.44 40 153183 30817 53165026
Fungal skin infection 16.78 9.44 36 153187 3936 53191907
Myelopathy 16.77 9.44 29 153194 2702 53193141
Low birth weight baby 16.75 9.44 48 153175 6289 53189554
Ulcer 16.73 9.44 109 153114 20510 53175333
Leukocytosis 16.69 9.44 125 153098 24609 53171234
Transient ischaemic attack 16.67 9.44 50 153173 35675 53160168
Fusarium infection 16.67 9.44 14 153209 605 53195238
Haemorrhagic varicella syndrome 16.66 9.44 4 153219 4 53195839
Ultrasound ovary abnormal 16.58 9.44 7 153216 80 53195763
Blood creatinine decreased 16.48 9.44 42 153181 5136 53190707
Cytomegalovirus hepatitis 16.44 9.44 11 153212 335 53195508
Foetal exposure during delivery 16.42 9.44 6 153217 45 53195798
Bone marrow failure 16.42 9.44 145 153078 29970 53165873
Leukocyturia 16.39 9.44 18 153205 1089 53194754
Creatinine urine decreased 16.38 9.44 9 153214 190 53195653
Dyspnoea 16.31 9.44 1456 151767 584776 52611067
Pneumonia acinetobacter 16.29 9.44 5 153218 20 53195823
Capillaritis 16.28 9.44 7 153216 84 53195759
Pneumonia bacterial 16.23 9.44 55 153168 7885 53187958
Tri-iodothyronine free decreased 16.14 9.44 10 153213 266 53195577
Meningomyelitis herpes 16.10 9.44 5 153218 21 53195822
Poor venous access 16.09 9.44 64 153159 9911 53185932
Osteoporosis 16.05 9.44 204 153019 46256 53149587
Intestine transplant rejection 15.98 9.44 6 153217 49 53195794
Ureteral disorder 15.94 9.44 10 153213 272 53195571
Chest pain 15.91 9.44 420 152803 189765 53006078
Tendon rupture 15.89 9.44 55 153168 7969 53187874
Band neutrophil count increased 15.88 9.44 11 153212 355 53195488
Foetal growth restriction 15.83 9.44 51 153172 7123 53188720
Cestode infection 15.78 9.44 10 153213 277 53195566
Blood immunoglobulin M decreased 15.73 9.44 15 153208 767 53195076
Weight increased 15.66 9.44 728 152495 203839 52992004
Mycobacterial infection 15.65 9.44 22 153201 1713 53194130
Monoparesis 15.57 9.44 21 153202 1573 53194270
Parainfluenzae virus infection 15.56 9.44 24 153199 2032 53193811
Rash erythematous 15.56 9.44 171 153052 37452 53158391
Seroconversion test positive 15.56 9.44 5 153218 24 53195819
Steroid withdrawal syndrome 15.55 9.44 13 153210 558 53195285
Product dispensing error 15.55 9.44 5 153218 10235 53185608
Inflammatory marker increased 15.51 9.44 46 153177 6144 53189699
Hypokalaemia 15.46 9.44 190 153033 96327 53099516
Pneumocephalus 15.46 9.44 8 153215 149 53195694
Ovarian fibroma 15.44 9.44 7 153216 96 53195747
Premenstrual syndrome 15.32 9.44 14 153209 678 53195165
Toxic epidermal necrolysis 15.32 9.44 118 153105 23432 53172411
Malacoplakia 15.31 9.44 7 153216 98 53195745
Central obesity 15.31 9.44 17 153206 1041 53194802
Organic brain syndrome 15.24 9.44 9 153214 219 53195624
Polyglandular disorder 15.23 9.44 5 153218 26 53195817
Infected varicose vein 15.23 9.44 5 153218 26 53195817
Thrombosis 15.22 9.44 107 153116 60686 53135157
Monocyte percentage decreased 15.18 9.44 8 153215 155 53195688
Autoimmune thyroiditis 15.14 9.44 31 153192 3280 53192563
Renal tubular necrosis 15.12 9.44 69 153154 11350 53184493
White blood cell count increased 15.11 9.44 201 153022 46044 53149799
Underdose 15.11 9.44 24 153199 21498 53174345
Tubulointerstitial nephritis 15.11 9.44 90 153133 16414 53179429
Bronchiolitis obliterans syndrome 15.06 9.44 7 153216 102 53195741
Germ cell cancer 15.01 9.44 6 153217 59 53195784
Nail bed inflammation 14.95 9.44 11 153212 391 53195452
Cardio-respiratory arrest 14.92 9.44 103 153120 58655 53137188
Suicidal ideation 14.91 9.44 107 153116 60404 53135439
Blood count abnormal 14.89 9.44 22 153201 20293 53175550
Blood immunoglobulin G decreased 14.89 9.44 23 153200 1950 53193893
Treatment noncompliance 14.87 9.44 47 153176 32988 53162855
Scleroderma renal crisis 14.85 9.44 10 153213 308 53195535
Skin fissures 14.83 9.44 57 153166 8688 53187155
Microangiopathic haemolytic anaemia 14.81 9.44 12 153211 493 53195350
Hypoproteinaemia 14.78 9.44 23 153200 1963 53193880
Immune effector cell-associated neurotoxicity syndrome 14.77 9.44 17 153206 1083 53194760
Abscess 14.76 9.44 84 153139 15072 53180771
Hepatic cirrhosis 14.75 9.44 18 153205 18004 53177839
Type I hypersensitivity 14.75 9.44 27 153196 2630 53193213
Myelocyte percentage increased 14.73 9.44 8 153215 165 53195678
Mental status changes 14.70 9.44 61 153162 39510 53156333
Type IIb hyperlipidaemia 14.64 9.44 5 153218 30 53195813
Parathyroid hyperplasia 14.60 9.44 8 153215 168 53195675
Endocrine ophthalmopathy 14.59 9.44 10 153213 317 53195526
Delayed engraftment 14.59 9.44 7 153216 110 53195733
Erythrosis 14.58 9.44 6 153217 64 53195779
Trichodysplasia spinulosa 14.56 9.44 12 153211 505 53195338
Pseudomonal sepsis 14.52 9.44 24 153199 2155 53193688
Blood beta-D-glucan increased 14.51 9.44 9 153214 240 53195603
Complications of transplanted liver 14.50 9.44 11 153212 410 53195433
Haemostasis 14.48 9.44 9 153214 241 53195602
Adenoviral haemorrhagic cystitis 14.47 9.44 8 153215 171 53195672
Vaginal haemorrhage 14.46 9.44 35 153188 26806 53169037
Hepatic artery aneurysm 14.44 9.44 4 153219 10 53195833
Pseudomonal bacteraemia 14.37 9.44 19 153204 1396 53194447
Cutaneous lupus erythematosus 14.28 9.44 27 153196 2696 53193147
Thyroid stimulating immunoglobulin increased 14.26 9.44 7 153216 116 53195727
Nosocomial infection 14.23 9.44 21 153202 1710 53194133
Microsporidia infection 14.21 9.44 9 153214 249 53195594
Injection site haemorrhage 14.19 9.44 26 153197 22025 53173818
Polychondritis 14.18 9.44 11 153212 424 53195419
Pneumonia pseudomonal 14.13 9.44 24 153199 2204 53193639
Urinary casts 14.11 9.44 13 153210 636 53195207
Gamma-glutamyltransferase increased 14.10 9.44 153 153070 33402 53162441
Atypical haemolytic uraemic syndrome 14.09 9.44 12 153211 529 53195314
Tardive dyskinesia 14.05 9.44 3 153220 8067 53187776
Refractory anaemia with an excess of blasts 14 9.44 11 153212 432 53195411
Laryngeal mass 13.98 9.44 5 153218 35 53195808
Drug withdrawal syndrome 13.97 9.44 38 153185 27984 53167859
Injection site warmth 13.96 9.44 12 153211 14116 53181727
Blood loss anaemia 13.96 9.44 4 153219 8819 53187024
Incorrect route of product administration 13.95 9.44 21 153202 19223 53176620
Multiple sclerosis 13.92 9.44 129 153094 27024 53168819
Chest discomfort 13.91 9.44 380 152843 99315 53096528
Product substitution issue 13.90 9.44 15 153208 15851 53179992
Mucocutaneous leishmaniasis 13.90 9.44 10 153213 343 53195500
Hepatic infarction 13.88 9.44 13 153210 650 53195193
Influenza like illness 13.86 9.44 110 153113 60749 53135094
Enteritis 13.85 9.44 50 153173 7396 53188447
Cytokine release syndrome 13.80 9.44 53 153170 8076 53187767
Haemodynamic instability 13.75 9.44 55 153168 8539 53187304
Moraxella infection 13.55 9.44 10 153213 357 53195486
Nodal osteoarthritis 13.53 9.44 14 153209 791 53195052
Muscle hypertrophy 13.52 9.44 6 153217 78 53195765
Coordination abnormal 13.51 9.44 69 153154 11882 53183961
Mucous stools 13.45 9.44 28 153195 2998 53192845
Coagulation factor VIII level increased 13.45 9.44 4 153219 14 53195829
Occult blood 13.42 9.44 17 153206 1197 53194646
Monocyte count decreased 13.40 9.44 22 153201 1964 53193879
Diffuse large B-cell lymphoma refractory 13.40 9.44 16 153207 1060 53194783
Urine leukocyte esterase 13.35 9.44 7 153216 134 53195709
Angiocentric lymphoma 13.33 9.44 12 153211 570 53195273
Specific gravity urine increased 13.32 9.44 8 153215 201 53195642
Diabetic macroangiopathy 13.31 9.44 7 153216 135 53195708
Excessive skin 13.31 9.44 7 153216 135 53195708
Spinal cord paralysis 13.20 9.44 5 153218 42 53195801
Acarodermatitis 13.19 9.44 15 153208 943 53194900
Systemic inflammatory response syndrome 13.19 9.44 41 153182 5619 53190224
Abnormal dreams 13.16 9.44 7 153216 10594 53185249
Coloboma 13.06 9.44 6 153217 85 53195758
Oropharyngeal plaque 13.06 9.44 9 153214 288 53195555
Butterfly rash 13.03 9.44 16 153207 1091 53194752
Gait disturbance 12.96 9.44 352 152871 158490 53037353
Paraparesis 12.96 9.44 23 153200 2187 53193656
Anaemia 12.95 9.44 656 152567 276062 52919781
Dystonia 12.94 9.44 11 153212 13010 53182833
Meningitis listeria 12.89 9.44 11 153212 486 53195357
Spinal cord infarction 12.84 9.44 9 153214 296 53195547
Asymptomatic bacteriuria 12.84 9.44 9 153214 296 53195547
Hepatic haemorrhage 12.83 9.44 11 153212 489 53195354
Herpes simplex oesophagitis 12.82 9.44 7 153216 146 53195697
Ophthalmoplegia 12.81 9.44 16 153207 1111 53194732
Paradoxical drug reaction 12.76 9.44 29 153194 3296 53192547
Moyamoya disease 12.70 9.44 5 153218 47 53195796
Cryptococcal fungaemia 12.70 9.44 5 153218 47 53195796
Heart transplant rejection 12.70 9.44 11 153212 496 53195347
Skin striae 12.69 9.44 16 153207 1121 53194722
Product contamination 12.66 9.44 12 153211 609 53195234
Beta 2 microglobulin increased 12.65 9.44 7 153216 150 53195693
Carcinoma in situ 12.64 9.44 6 153217 92 53195751
Herpes simplex encephalitis 12.63 9.44 9 153214 304 53195539
Product complaint 12.62 9.44 10 153213 12247 53183596
Candida test positive 12.62 9.44 15 153208 989 53194854
Lymphocele 12.59 9.44 14 153209 859 53194984
Adjusted calcium decreased 12.57 9.44 7 153216 152 53195691
Low cardiac output syndrome 12.56 9.44 9 153214 307 53195536
Magnesium deficiency 12.55 9.44 11 153212 504 53195339
Therapy cessation 12.53 9.44 40 153183 27985 53167858
Nose deformity 12.52 9.44 7 153216 153 53195690
Mean cell haemoglobin concentration decreased 12.48 9.44 27 153196 2970 53192873
Seizure 12.47 9.44 280 152943 129229 53066614
Hypertrichosis 12.43 9.44 15 153208 1005 53194838
Anxiety 12.40 9.44 451 152772 196253 52999590
Hyperpyrexia 12.37 9.44 29 153194 3365 53192478
Cryptococcal meningoencephalitis 12.35 9.44 5 153218 51 53195792
Nightmare 12.27 9.44 20 153203 17731 53178112
Hepatocellular injury 12.27 9.44 136 153087 29850 53165993
Cough 12.26 9.44 876 152347 256017 52939826
Paraesthesia ear 12.17 9.44 7 153216 162 53195681
Ureteric stenosis 12.16 9.44 12 153211 640 53195203
Peritonitis 12.13 9.44 105 153118 21582 53174261
Bursitis 12.11 9.44 108 153115 22384 53173459
Hepatic enzyme increased 12.10 9.44 273 152950 125922 53069921
Chronic graft versus host disease oral 12.08 9.44 6 153217 102 53195741
Subcutaneous haematoma 12.06 9.44 19 153204 1639 53194204
Aspergillosis oral 12.04 9.44 3 153220 4 53195839
Enterocolitis viral 12.03 9.44 8 153215 241 53195602
Renal impairment 12.03 9.44 319 152904 82999 53112844
Transaminases increased 12.03 9.44 136 153087 29996 53165847
Varicella 11.99 9.44 20 153203 1809 53194034
Anti-neutrophil cytoplasmic antibody positive vasculitis 11.94 9.44 23 153200 2328 53193515
Kidney fibrosis 11.91 9.44 19 153204 1656 53194187
Pterygium 11.90 9.44 7 153216 169 53195674
Alopecia scarring 11.88 9.44 6 153217 106 53195737
Mycoplasma test positive 11.85 9.44 5 153218 57 53195786
Enterobacter pneumonia 11.85 9.44 4 153219 23 53195820
Lower limb fracture 11.83 9.44 14 153209 14191 53181652
Vascular rupture 11.79 9.44 17 153206 1355 53194488
Epstein-Barr virus associated lymphoma 11.79 9.44 10 153213 438 53195405
Ureteral necrosis 11.78 9.44 5 153218 58 53195785
Fungal infection 11.74 9.44 143 153080 32103 53163740
Transplant dysfunction 11.72 9.44 36 153187 4902 53190941
Laryngitis 11.68 9.44 61 153162 10594 53185249
Respiratory arrest 11.67 9.44 53 153170 33487 53162356
General physical health deterioration 11.64 9.44 327 152896 146615 53049228
CSF oligoclonal band present 11.63 9.44 6 153217 111 53195732
Coronavirus infection 11.63 9.44 27 153196 3113 53192730
Cryptococcal cutaneous infection 11.63 9.44 5 153218 60 53195783
Macular degeneration 11.62 9.44 11 153212 12350 53183493
Vasculitis necrotising 11.61 9.44 11 153212 558 53195285
Metastases to liver 11.60 9.44 28 153195 21468 53174375
Pyometra 11.58 9.44 6 153217 112 53195731
Erythema migrans 11.57 9.44 4 153219 25 53195818
Bacterial vulvovaginitis 11.55 9.44 12 153211 681 53195162
Cystitis viral 11.53 9.44 6 153217 113 53195730
Bacterial infection 11.45 9.44 88 153135 17459 53178384
Flatulence 11.45 9.44 49 153174 31468 53164375
Neonatal pneumonia 11.44 9.44 4 153219 26 53195817
Acute motor axonal neuropathy 11.44 9.44 4 153219 26 53195817
Salmonella test positive 11.44 9.44 4 153219 26 53195817
Ecthyma 11.42 9.44 8 153215 263 53195580
Disseminated cytomegaloviral infection 11.41 9.44 7 153216 183 53195660
Metastases to bone 11.39 9.44 24 153199 19304 53176539
Normochromic anaemia 11.37 9.44 8 153215 265 53195578
Lung disorder 11.34 9.44 197 153026 47682 53148161
Thyroid stimulating immunoglobulin 11.34 9.44 5 153218 64 53195779
Irritability 11.32 9.44 48 153175 30905 53164938
Osseous cryptococcosis 11.29 9.44 3 153220 6 53195837
Complications of transplant surgery 11.27 9.44 7 153216 187 53195656
Fear 11.27 9.44 19 153204 16622 53179221
Passenger lymphocyte syndrome 11.27 9.44 5 153218 65 53195778
Escherichia pyelonephritis 11.21 9.44 10 153213 469 53195374
Waxy flexibility 11.21 9.44 6 153217 120 53195723
Cells in urine 11.21 9.44 7 153216 189 53195654
Toxoplasmosis 11.20 9.44 17 153206 1419 53194424
Paralysis 11.19 9.44 55 153168 9329 53186514
Immune-mediated arthritis 11.19 9.44 4 153219 28 53195815
Mycobacterium kansasii infection 11.17 9.44 6 153217 121 53195722
Aspergilloma 11.14 9.44 7 153216 191 53195652
Menstruation irregular 11.13 9.44 45 153178 7021 53188822
Encephalitis brain stem 11.12 9.44 6 153217 122 53195721
Pneumonia legionella 11.10 9.44 17 153206 1431 53194412
Mean cell haemoglobin concentration increased 11.09 9.44 10 153213 476 53195367
Retinal depigmentation 11.08 9.44 8 153215 276 53195567
Reticulocytosis 11.08 9.44 6 153217 123 53195720
Encephalitis Japanese B 11.07 9.44 4 153219 29 53195814
Cancer in remission 11.07 9.44 4 153219 29 53195814
Hemivertebra 10.99 9.44 6 153217 125 53195718
Thrombocytopenic purpura 10.99 9.44 16 153207 1287 53194556
Human herpes virus 8 test positive 10.98 9.44 3 153220 7 53195836
Erectile dysfunction 10.98 9.44 3 153220 7 53195836
Palmar erythema 10.97 9.44 18 153205 1606 53194237
Neurosarcoidosis 10.92 9.44 7 153216 198 53195645
Meningitis cryptococcal 10.91 9.44 16 153207 1295 53194548
Breast cancer 10.88 9.44 90 153133 49268 53146575
B-lymphocyte count increased 10.87 9.44 6 153217 128 53195715
Angina pectoris 10.85 9.44 44 153179 28681 53167162
Inflammatory pain 10.84 9.44 12 153211 732 53195111
Immunosuppression 10.84 9.44 48 153175 7796 53188047
Conjunctivitis 10.83 9.44 85 153138 16972 53178871
Post procedural bile leak 10.82 9.44 6 153217 129 53195714
Bile duct stenosis 10.81 9.44 15 153208 1154 53194689
Aplastic anaemia 10.81 9.44 50 153173 8271 53187572
Bradyphrenia 10.79 9.44 3 153220 6747 53189096
Head injury 10.77 9.44 38 153185 25795 53170048
Creatinine urine increased 10.76 9.44 7 153216 203 53195640
Hepatic artery thrombosis 10.75 9.44 5 153218 73 53195770
Right ventricular failure 10.71 9.44 20 153203 16823 53179020
Chronic graft versus host disease in eye 10.69 9.44 5 153218 74 53195769
T-lymphocyte count decreased 10.69 9.44 8 153215 292 53195551
Tri-iodothyronine free increased 10.67 9.44 7 153216 206 53195637
Glomerulonephritis membranous 10.66 9.44 11 153212 619 53195224
Sensory loss 10.64 9.44 48 153175 7857 53187986
Body temperature decreased 10.64 9.44 83 153140 16544 53179299
Endometrial ablation 10.62 9.44 13 153210 884 53194959
Impaired work ability 10.58 9.44 15 153208 14075 53181768
Dementia 10.56 9.44 20 153203 16730 53179113
Acute kidney injury 10.54 9.44 609 152614 253259 52942584
Injection site mass 10.54 9.44 19 153204 16195 53179648
Eosinophilic myocarditis 10.52 9.44 9 153214 399 53195444
Calcification of muscle 10.52 9.44 4 153219 34 53195809
Vesicoureteric reflux 10.50 9.44 7 153216 212 53195631
Drug tolerance decreased 10.48 9.44 4 153219 7354 53188489
Hallucination, auditory 10.46 9.44 11 153212 11762 53184081
Cytokine storm 10.46 9.44 8 153215 302 53195541
Papilloma viral infection 10.45 9.44 16 153207 1346 53194497
Psychiatric decompensation 10.45 9.44 16 153207 1346 53194497
Drug interaction 10.44 9.44 519 152704 218810 52977033
Pneumonia mycoplasmal 10.44 9.44 13 153210 900 53194943
Myocardiac abscess 10.43 9.44 3 153220 9 53195834
Visual tracking test abnormal 10.43 9.44 3 153220 9 53195834
Blood lactate dehydrogenase increased 10.43 9.44 102 153121 21679 53174164
Achromobacter infection 10.41 9.44 4 153219 35 53195808
Acute disseminated encephalomyelitis 10.38 9.44 7 153216 216 53195627
Endocarditis 10.35 9.44 37 153186 5447 53190396
Injection site induration 10.34 9.44 6 153217 8652 53187191
Peripheral sensorimotor neuropathy 10.34 9.44 16 153207 1359 53194484
Oesophageal adenocarcinoma recurrent 10.32 9.44 4 153219 36 53195807
Genital herpes 10.30 9.44 18 153205 1691 53194152
Wound infection bacterial 10.28 9.44 9 153214 412 53195431
Intestinal infarction 10.26 9.44 14 153209 1060 53194783
Plasma cells decreased 10.22 9.44 4 153219 37 53195806
Sopor 10.21 9.44 29 153194 21055 53174788
Nitrite urine 10.20 9.44 3 153220 10 53195833
Pneumonia fungal 10.18 9.44 33 153190 4623 53191220
Acute myocardial infarction 10.14 9.44 55 153168 33180 53162663
Coma 10.13 9.44 121 153102 61662 53134181
Infestation 10.13 9.44 4 153219 38 53195805
Histiocytic sarcoma 10.12 9.44 5 153218 84 53195759
Fracture 10.10 9.44 23 153200 17996 53177847
Microangiopathy 10.09 9.44 13 153210 931 53194912
Arrhythmia 10.08 9.44 63 153160 36716 53159127
Autoimmune haemolytic anaemia 10.06 9.44 32 153191 4439 53191404
Blindness 10.05 9.44 90 153133 18673 53177170
Serum ferritin increased 10.05 9.44 37 153186 5527 53190316
Encephalopathy 10.04 9.44 155 153068 36653 53159190
Tuberous sclerosis complex 10.02 9.44 5 153218 86 53195757
Lung transplant rejection 10.00 9.44 12 153211 799 53195044
Normal newborn 9.97 9.44 44 153179 7135 53188708
Paraspinal abscess 9.95 9.44 4 153219 40 53195803
Salivary gland mass 9.92 9.44 5 153218 88 53195755
Labelled drug-drug interaction medication error 9.89 9.44 10 153213 10889 53184954
Central venous pressure increased 9.86 9.44 5 153218 89 53195754
Graft complication 9.86 9.44 7 153216 235 53195608
Neurological decompensation 9.86 9.44 22 153201 2470 53193373
Crystalluria 9.83 9.44 9 153214 437 53195406
Persecutory delusion 9.81 9.44 23 153200 2669 53193174
Crying 9.79 9.44 32 153191 22230 53173613
Endometrial disorder 9.78 9.44 11 153212 683 53195160
Parvimonas micra infection 9.77 9.44 3 153220 12 53195831
Skin irritation 9.74 9.44 6 153217 8378 53187465
Atypical mycobacterial infection 9.74 9.44 13 153210 964 53194879
Parkinsonism 9.73 9.44 7 153216 9006 53186837
Haematocrit decreased 9.73 9.44 156 153067 37175 53158668
Unmasking of previously unidentified disease 9.72 9.44 12 153211 823 53195020
Pneumothorax 9.70 9.44 77 153146 15430 53180413
Perineal ulceration 9.69 9.44 4 153219 43 53195800
Central nervous system lesion 9.68 9.44 56 153167 10106 53185737
Body temperature increased 9.68 9.44 140 153083 32659 53163184
Intestinal obstruction 9.65 9.44 46 153177 28695 53167148
Abdominal pain upper 9.65 9.44 385 152838 165906 53029937
CSF test abnormal 9.64 9.44 8 153215 340 53195503
Graft ischaemia 9.61 9.44 4 153219 44 53195799
Treatment failure 9.60 9.44 288 152935 128115 53067728
Hereditary angioedema 9.59 9.44 3 153220 6250 53189593
Eosinophil percentage increased 9.58 9.44 13 153210 979 53194864
Lupus pancreatitis 9.58 9.44 3 153220 13 53195830
Pyonephrosis 9.58 9.44 3 153220 13 53195830
Morganella infection 9.53 9.44 10 153213 574 53195269
Wheezing 9.53 9.44 131 153092 65144 53130699
Small intestinal obstruction 9.52 9.44 22 153201 17125 53178718
Immature granulocyte count increased 9.50 9.44 8 153215 347 53195496
Lymphocyte count increased 9.48 9.44 25 153198 3121 53192722
Bilirubin conjugated increased 9.48 9.44 23 153200 2728 53193115
Herpes simplex viraemia 9.48 9.44 6 153217 166 53195677

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cytomegalovirus infection 807.96 10.12 652 99656 24812 32388406
Off label use 678.49 10.12 2276 98032 304044 32109174
Product use in unapproved indication 516.10 10.12 947 99361 86257 32326961
Transplant rejection 342.52 10.12 268 100040 9731 32403487
Death 318.82 10.12 430 99878 382087 32031131
Kidney transplant rejection 316.93 10.12 231 100077 7524 32405694
Graft versus host disease 309.69 10.12 261 100047 10545 32402673
Drug ineffective for unapproved indication 301.56 10.12 287 100021 13625 32399593
Pneumocystis jirovecii pneumonia 295.91 10.12 327 99981 18543 32394675
Aspergillus infection 292.14 10.12 260 100048 11314 32401904
Mucormycosis 274.18 10.12 187 100121 5467 32407751
Posterior reversible encephalopathy syndrome 263.58 10.12 226 100082 9350 32403868
Multiple organ dysfunction syndrome 253.62 10.12 622 99686 69232 32343986
Drug ineffective 247.83 10.12 2021 98287 381456 32031762
Bronchopulmonary aspergillosis 244.20 10.12 254 100054 13433 32399785
Post transplant lymphoproliferative disorder 234.36 10.12 172 100136 5662 32407556
Completed suicide 209.98 10.12 21 100287 92496 32320722
Respiratory failure 202.39 10.12 758 99550 106424 32306794
Epstein-Barr virus infection 200.57 10.12 170 100138 6920 32406298
Strongyloidiasis 192.92 10.12 112 100196 2449 32410769
Fatigue 192.30 10.12 507 99801 350194 32063024
Polyomavirus-associated nephropathy 179.85 10.12 121 100187 3456 32409762
Graft versus host disease in gastrointestinal tract 176.86 10.12 118 100190 3323 32409895
Drug abuse 170.16 10.12 23 100285 80220 32332998
Fall 169.56 10.12 214 100094 195987 32217231
Dizziness 168.63 10.12 241 100067 209377 32203841
Cytomegalovirus infection reactivation 166.78 10.12 113 100195 3266 32409952
Cytomegalovirus viraemia 163.58 10.12 148 100160 6579 32406639
Adenovirus infection 163.06 10.12 127 100181 4577 32408641
Complications of transplanted kidney 149.09 10.12 116 100192 4174 32409044
Acute graft versus host disease 144.88 10.12 135 100173 6235 32406983
Infusion related reaction 138.57 10.12 380 99928 45219 32367999
Thrombotic microangiopathy 131.12 10.12 154 100154 9328 32403890
Septic shock 130.98 10.12 489 99819 68500 32344718
Nausea 129.84 10.12 530 99778 320319 32092899
Product dose omission issue 126.72 10.12 80 100228 102495 32310723
Pneumonia cytomegaloviral 124.76 10.12 90 100218 2882 32410336
BK virus infection 121.86 10.12 109 100199 4772 32408446
Cystitis haemorrhagic 117.49 10.12 109 100199 5005 32408213
Candida infection 116.62 10.12 196 100112 16607 32396611
Cardiac failure congestive 112.13 10.12 61 100247 84791 32328427
Acute graft versus host disease in skin 110.70 10.12 104 100204 4853 32408365
Haemophagocytic lymphohistiocytosis 109.34 10.12 154 100154 11181 32402037
Nocardiosis 108.69 10.12 91 100217 3640 32409578
Klebsiella infection 107.27 10.12 128 100180 7884 32405334
Enterococcal infection 106.16 10.12 136 100172 9011 32404207
Asthenia 104.82 10.12 375 99933 235569 32177649
Graft versus host disease in skin 103.13 10.12 87 100221 3517 32409701
Syncope 102.38 10.12 77 100231 90047 32323171
Myocardial infarction 97.48 10.12 148 100160 125528 32287690
Pneumatosis intestinalis 96.72 10.12 82 100226 3338 32409880
Cytomegalovirus test positive 93.96 10.12 85 100223 3777 32409441
Delayed graft function 91.10 10.12 62 100246 1805 32411413
Focal segmental glomerulosclerosis 90.75 10.12 64 100244 1976 32411242
Pseudomonas infection 88.18 10.12 144 100164 11912 32401306
Steroid diabetes 86.79 10.12 60 100248 1793 32411425
Constipation 86.75 10.12 161 100147 126212 32287006
Cerebrovascular accident 86.71 10.12 83 100225 86237 32326981
Human herpesvirus 6 infection 86.41 10.12 62 100246 1968 32411250
Acute graft versus host disease in intestine 86.01 10.12 68 100240 2505 32410713
Toxicity to various agents 85.80 10.12 273 100035 177768 32235450
Drug resistance 84.81 10.12 206 100102 22759 32390459
Cytomegalovirus colitis 80.21 10.12 66 100242 2576 32410642
Disseminated mucormycosis 79.80 10.12 30 100278 227 32412991
Progressive multifocal leukoencephalopathy 78.21 10.12 120 100188 9411 32403807
Dehydration 77.74 10.12 177 100131 128781 32284437
Blood pressure fluctuation 76.91 10.12 183 100125 19952 32393266
Pneumomediastinum 76.68 10.12 57 100251 1913 32411305
Chronic allograft nephropathy 76.40 10.12 47 100261 1146 32412072
Nephropathy toxic 75.88 10.12 134 100174 11812 32401406
Renal tubular atrophy 74.55 10.12 46 100262 1128 32412090
Chronic graft versus host disease 73.14 10.12 79 100229 4361 32408857
Acute graft versus host disease in liver 72.80 10.12 48 100260 1324 32411894
Hospitalisation 72.66 10.12 30 100278 48941 32364277
Lymphocyte count decreased 72.25 10.12 184 100124 20935 32392283
Vomiting 70.47 10.12 432 99876 235125 32178093
Lymphopenia 69.43 10.12 144 100164 14312 32398906
Hypoglycaemia 69.08 10.12 41 100267 54341 32358877
Liver transplant rejection 68.55 10.12 56 100252 2163 32411055
COVID-19 pneumonia 67.66 10.12 107 100201 8613 32404605
Depression 67.16 10.12 123 100185 96937 32316281
Confusional state 66.44 10.12 223 100085 142892 32270326
Intentional overdose 65.86 10.12 23 100285 41578 32371640
Overdose 65.14 10.12 105 100203 86972 32326246
Pneumocystis jirovecii infection 64.06 10.12 46 100262 1462 32411756
Pulmonary mucormycosis 62.92 10.12 32 100276 532 32412686
Mycobacterium chelonae infection 61.77 10.12 33 100275 610 32412608
Enterobacter infection 61.22 10.12 53 100255 2220 32410998
Fungal infection 59.73 10.12 140 100168 15115 32398103
Kidney fibrosis 58.75 10.12 51 100257 2144 32411074
Intentional product use issue 58.66 10.12 272 100036 41939 32371279
Acute respiratory distress syndrome 58.25 10.12 191 100117 25062 32388156
COVID-19 57.45 10.12 223 100085 31792 32381426
Bacterial sepsis 57.05 10.12 76 100232 5232 32407986
Large intestine perforation 56.62 10.12 95 100213 8035 32405183
Disseminated intravascular coagulation 55.91 10.12 178 100130 22998 32390220
Herpes simplex 55.48 10.12 74 100234 5100 32408118
Infection reactivation 55.45 10.12 38 100270 1119 32412099
Cytomegalovirus enteritis 53.90 10.12 27 100281 434 32412784
Coronary artery disease 53.24 10.12 45 100263 49661 32363557
Aplasia 53.05 10.12 67 100241 4375 32408843
Phaeohyphomycosis 52.81 10.12 33 100275 828 32412390
Immunosuppressant drug level increased 52.76 10.12 72 100236 5073 32408145
Therapy non-responder 52.65 10.12 220 100088 32434 32380784
Sepsis 52.09 10.12 732 99576 158102 32255116
Leukopenia 51.64 10.12 340 99968 59782 32353436
Parvovirus B19 infection 51.20 10.12 29 100279 604 32412614
Necrotising retinitis 50.34 10.12 32 100276 828 32412390
Transplant dysfunction 50.04 10.12 49 100259 2408 32410810
Feeling abnormal 49.91 10.12 68 100240 60355 32352863
JC virus infection 49.21 10.12 44 100264 1925 32411293
Cushingoid 48.35 10.12 50 100258 2624 32410594
Oxygen saturation decreased 48.19 10.12 283 100025 47816 32365402
Rebound effect 47.57 10.12 44 100264 2012 32411206
Cardiac disorder 47.21 10.12 36 100272 41830 32371388
Cytomegalovirus chorioretinitis 47.19 10.12 57 100251 3555 32409663
Anxiety 47.02 10.12 146 100162 95859 32317359
Transplant failure 46.91 10.12 50 100258 2718 32410500
Disease recurrence 46.91 10.12 132 100176 15932 32397286
Product prescribing error 45.96 10.12 4 100304 19713 32393505
Decreased appetite 45.91 10.12 299 100009 160514 32252704
Pneumonia fungal 45.91 10.12 75 100233 6205 32407013
Dyspnoea 45.87 10.12 814 99494 361231 32051987
Plasma cell myeloma 45.44 10.12 67 100241 57547 32355671
Central nervous system fungal infection 45.34 10.12 22 100286 329 32412889
Wrong technique in product usage process 45.13 10.12 26 100282 35033 32378185
Renal transplant failure 45.09 10.12 33 100275 1081 32412137
Skin necrosis 44.42 10.12 68 100240 5321 32407897
Acinetobacter infection 44.41 10.12 33 100275 1107 32412111
Serotonin syndrome 44.23 10.12 4 100304 19113 32394105
Rhabdomyolysis 44.10 10.12 88 100220 67177 32346041
Pain 43.85 10.12 369 99939 187187 32226031
Systemic mycosis 43.81 10.12 36 100272 1402 32411816
Viraemia 43.56 10.12 34 100274 1229 32411989
Injection site pain 43.30 10.12 24 100284 33034 32380184
Pneumonia pseudomonal 42.80 10.12 55 100253 3654 32409564
Graft versus host disease in liver 42.66 10.12 32 100276 1089 32412129
Proteinuria 42.50 10.12 134 100174 17221 32395997
Myopathy 42.15 10.12 102 100206 11239 32401979
Chorioretinopathy 41.93 10.12 36 100272 1491 32411727
Suicide attempt 41.72 10.12 34 100274 38210 32375008
Cytomegalovirus oesophagitis 41.36 10.12 22 100286 403 32412815
Escherichia infection 41.26 10.12 77 100231 7083 32406135
Hyperglycaemia 41.15 10.12 230 100078 38161 32375057
Epstein-Barr virus associated lymphoproliferative disorder 41.13 10.12 39 100269 1841 32411377
Fusarium infection 41.12 10.12 31 100277 1063 32412155
Aggression 40.56 10.12 37 100271 39352 32373866
Dural arteriovenous fistula 40.40 10.12 12 100296 38 32413180
Epstein-Barr viraemia 40.33 10.12 30 100278 1008 32412210
Incision site pain 40.32 10.12 40 100268 1997 32411221
Symptom masked 40.14 10.12 24 100284 555 32412663
Blood pressure diastolic abnormal 39.94 10.12 42 100266 2248 32410970
Pneumothorax 39.72 10.12 132 100176 17438 32395780
Renal tubular necrosis 39.71 10.12 124 100184 15854 32397364
Product quality issue 39.60 10.12 6 100302 19227 32393991
Somnolence 39.59 10.12 175 100133 103622 32309596
Malaise 39.40 10.12 353 99955 176785 32236433
Muscle spasms 38.96 10.12 101 100207 70317 32342901
Staphylococcal sepsis 38.83 10.12 91 100217 9822 32403396
Human herpesvirus 8 infection 38.79 10.12 27 100281 816 32412402
Glomerulosclerosis 38.69 10.12 26 100282 741 32412477
Varicella zoster virus infection 37.27 10.12 34 100274 1527 32411691
Glomerulonephritis 37.17 10.12 37 100271 1855 32411363
Blood pressure systolic abnormal 37.12 10.12 39 100269 2085 32411133
Red blood cells urine positive 37.09 10.12 36 100272 1750 32411468
Tremor 36.75 10.12 128 100180 81149 32332069
Pneumonia acinetobacter 36.46 10.12 13 100295 83 32413135
Hypoalbuminaemia 36.35 10.12 99 100209 11723 32401495
Oliguria 36.05 10.12 79 100229 8155 32405063
Pyrexia 36.02 10.12 1264 99044 318704 32094514
Mycobacterium abscessus infection 35.78 10.12 23 100285 607 32412611
Granulomatosis with polyangiitis 34.54 10.12 27 100281 978 32412240
Insomnia 33.72 10.12 177 100131 100171 32313047
Diffuse alveolar damage 33.68 10.12 37 100271 2082 32411136
Oedema peripheral 33.62 10.12 210 100098 113881 32299337
Blood pressure increased 33.32 10.12 383 99925 78971 32334247
Pemphigus 33.18 10.12 30 100278 1332 32411886
Pulmonary alveolar haemorrhage 33.05 10.12 70 100238 7059 32406159
Balance disorder 32.99 10.12 44 100264 39415 32373803
Atrial fibrillation 32.77 10.12 218 100090 116486 32296732
Amoebic colitis 32.77 10.12 11 100297 57 32413161
Aplastic anaemia 32.58 10.12 71 100237 7302 32405916
Lung abscess 32.53 10.12 41 100267 2671 32410547
Cryptococcosis 32.51 10.12 36 100272 2044 32411174
Cytomegalovirus hepatitis 32.47 10.12 17 100291 301 32412917
Gastroenteritis norovirus 32.38 10.12 31 100277 1481 32411737
Penicillium infection 32.36 10.12 12 100296 87 32413131
Protein urine present 32.14 10.12 57 100251 5040 32408178
Immunosuppressant drug level decreased 32.14 10.12 29 100279 1284 32411934
Condition aggravated 31.87 10.12 665 99643 154996 32258222
Hallucination 31.84 10.12 72 100236 52547 32360671
Opportunistic infection 31.81 10.12 32 100276 1625 32411593
Inappropriate schedule of product administration 31.73 10.12 58 100250 45767 32367451
Loss of personal independence in daily activities 31.65 10.12 22 100286 26811 32386407
Intensive care unit acquired weakness 31.45 10.12 25 100283 928 32412290
Diffuse large B-cell lymphoma 31.33 10.12 76 100232 8386 32404832
Pulmonary nocardiosis 31.20 10.12 21 100287 600 32412618
Cytomegalovirus enterocolitis 31.09 10.12 24 100284 853 32412365
Bradycardia 30.83 10.12 115 100193 71447 32341771
Fungal skin infection 30.74 10.12 39 100269 2558 32410660
Pathogen resistance 30.61 10.12 81 100227 9429 32403789
Nephrotic syndrome 30.60 10.12 69 100239 7260 32405958
Lethargy 30.54 10.12 50 100258 41178 32372040
Parvovirus infection 30.54 10.12 19 100289 473 32412745
Headache 30.52 10.12 424 99884 195773 32217445
Back pain 30.40 10.12 209 100099 110844 32302374
Cutaneous mucormycosis 30.31 10.12 12 100296 106 32413112
Pneumoperitoneum 30.24 10.12 33 100275 1843 32411375
Adenoviral hepatitis 30.12 10.12 15 100293 238 32412980
Stress 30.09 10.12 18 100290 23764 32389454
Chest pain 29.53 10.12 243 100065 123894 32289324
Contraindicated product administered 29.42 10.12 11 100297 19065 32394153
Low birth weight baby 29.38 10.12 66 100242 6928 32406290
Disseminated strongyloidiasis 29.17 10.12 11 100297 84 32413134
Antineutrophil cytoplasmic antibody positive 29.09 10.12 20 100288 592 32412626
Dysphagia 29.03 10.12 95 100213 61381 32351837
Human polyomavirus infection 29.01 10.12 21 100287 676 32412542
Vasculitis 28.96 10.12 75 100233 8618 32404600
International normalised ratio increased 28.94 10.12 68 100240 48967 32364251
Renal graft infection 28.89 10.12 15 100293 261 32412957
Treatment noncompliance 28.66 10.12 25 100283 27177 32386041
Intestinal ischaemia 28.63 10.12 67 100241 7224 32405994
Fungaemia 28.28 10.12 37 100271 2502 32410716
American trypanosomiasis 28.12 10.12 14 100294 222 32412996
Drug interaction 28.03 10.12 489 99819 217696 32195522
Cholelithiasis 27.65 10.12 15 100293 20897 32392321
Respiratory arrest 27.62 10.12 29 100279 28879 32384339
Dry skin 27.50 10.12 22 100286 24956 32388262
Myalgia 27.44 10.12 143 100165 81087 32332131
Enterococcal bacteraemia 27.26 10.12 30 100278 1691 32411527
Dyskinesia 26.99 10.12 20 100288 23583 32389635
Angiosarcoma 26.93 10.12 15 100293 302 32412916
Leukocytosis 26.76 10.12 143 100165 23324 32389894
Unevaluable event 26.53 10.12 39 100269 33547 32379671
Psoriasis 26.40 10.12 65 100243 46058 32367160
Gastrointestinal candidiasis 26.29 10.12 12 100296 155 32413063
Klebsiella sepsis 25.95 10.12 30 100278 1786 32411432
Pneumonia cryptococcal 25.91 10.12 21 100287 802 32412416
Epstein-Barr virus associated lymphoma 25.86 10.12 19 100289 626 32412592
Scopulariopsis infection 25.67 10.12 11 100297 121 32413097
Diarrhoea 25.66 10.12 895 99413 363907 32049311
Transient ischaemic attack 25.65 10.12 25 100283 25769 32387449
Ureteric stenosis 25.45 10.12 25 100283 1233 32411985
Accidental overdose 25.38 10.12 14 100294 19325 32393893
Contusion 25.34 10.12 40 100268 33428 32379790
Pneumoretroperitoneum 25.30 10.12 9 100299 57 32413161
Apoptosis 25.25 10.12 13 100295 222 32412996
Polychondritis 25.24 10.12 12 100296 171 32413047
Erectile dysfunction 25.12 10.12 15 100293 19824 32393394
Abdominal abscess 25.08 10.12 46 100262 4175 32409043
Arrhythmia 25.06 10.12 44 100264 35259 32377959
Blood pressure systolic increased 24.82 10.12 113 100195 17283 32395935
Suicidal ideation 24.80 10.12 50 100258 38033 32375185
Systemic candida 24.73 10.12 38 100270 2983 32410235
Hypogammaglobulinaemia 24.52 10.12 57 100251 6119 32407099
Blood count abnormal 24.50 10.12 5 100303 12921 32400297
Haemolytic uraemic syndrome 24.44 10.12 31 100277 2033 32411185
Depressed mood 24.38 10.12 13 100295 18287 32394931
Accidental exposure to product 24.23 10.12 3 100305 11199 32402019
Hyperhidrosis 24.19 10.12 125 100183 71043 32342175
Splenic embolism 24.17 10.12 12 100296 189 32413029
Reticulocytosis 24.12 10.12 14 100294 306 32412912
Graft loss 24.11 10.12 21 100287 887 32412331
Extrapyramidal disorder 23.84 10.12 4 100304 11891 32401327
Restlessness 23.73 10.12 25 100283 24856 32388362
Treatment failure 23.71 10.12 204 100104 38959 32374259
Intra-abdominal haemorrhage 23.70 10.12 32 100276 2231 32410987
Device related sepsis 23.50 10.12 34 100274 2529 32410689
Pyelonephritis acute 23.45 10.12 28 100280 1725 32411493
Osmotic demyelination syndrome 23.37 10.12 19 100289 729 32412489
Hepatic artery thrombosis 23.29 10.12 13 100295 263 32412955
Listeriosis 23.23 10.12 21 100287 932 32412286
Lymphoproliferative disorder 23.18 10.12 34 100274 2561 32410657
Gait disturbance 23.16 10.12 149 100159 80259 32332959
Blood creatine phosphokinase increased 23.08 10.12 68 100240 45408 32367810
Herpes zoster meningoencephalitis 22.77 10.12 13 100295 275 32412943
Agitation 22.72 10.12 95 100213 57141 32356077
Diabetes mellitus 22.66 10.12 226 100082 44947 32368271
Skin striae 22.63 10.12 16 100292 496 32412722
Inflammatory marker increased 22.61 10.12 41 100267 3688 32409530
Lupus nephritis 22.36 10.12 13 100295 285 32412933
Immunosuppression 22.35 10.12 52 100256 5585 32407633
Obliterative bronchiolitis 22.35 10.12 23 100285 1200 32412018
Asthma 22.28 10.12 66 100242 43999 32369219
Peripheral swelling 22.14 10.12 122 100186 68223 32344995
Bronchopneumopathy 22.12 10.12 15 100293 434 32412784
Graft complication 22.06 10.12 14 100294 361 32412857
Corynebacterium infection 21.94 10.12 15 100293 440 32412778
Sideroblastic anaemia 21.89 10.12 12 100296 234 32412984
Immune reconstitution inflammatory syndrome 21.77 10.12 72 100236 9487 32403731
Diaphragmatic injury 21.72 10.12 10 100298 132 32413086
Perinephric abscess 21.57 10.12 7 100301 32 32413186
Atypical mycobacterial pneumonia 21.45 10.12 10 100298 136 32413082
Monocytopenia 21.33 10.12 9 100299 95 32413123
Nightmare 21.32 10.12 7 100301 13159 32400059
Cystitis escherichia 21.25 10.12 11 100297 190 32413028
Neuromyelitis optica spectrum disorder 21.19 10.12 10 100298 140 32413078
Blood beta-D-glucan increased 21.19 10.12 15 100293 466 32412752
Respiratory tract infection fungal 21.12 10.12 18 100290 738 32412480
Thrombocytopenia 21.11 10.12 603 99705 147696 32265522
Dermatophytosis 21.10 10.12 12 100296 252 32412966
Cerebral aspergillosis 21.09 10.12 24 100284 1404 32411814
Tuberculosis 21.01 10.12 67 100241 8662 32404556
Neutrophil percentage increased 20.98 10.12 28 100280 1931 32411287
Encephalitis autoimmune 20.94 10.12 16 100292 560 32412658
Autoimmune colitis 20.74 10.12 20 100288 964 32412254
Bronchopleural fistula 20.66 10.12 15 100293 485 32412733
Hepatic failure 20.64 10.12 184 100124 35496 32377722
Gonococcal infection 20.58 10.12 7 100301 38 32413180
Cardiac arrest 20.55 10.12 195 100113 96581 32316637
Mobility decreased 20.53 10.12 35 100273 28374 32384844
Seronegative arthritis 20.52 10.12 20 100288 977 32412241
Prostate cancer 20.52 10.12 33 100275 27373 32385845
Rheumatoid arthritis 20.51 10.12 219 100089 44325 32368893
Toxic epidermal necrolysis 20.50 10.12 121 100187 20472 32392746
Urine abnormality 20.50 10.12 27 100281 1838 32411380
Mixed liver injury 20.49 10.12 32 100276 2548 32410670
Bacteraemia 20.48 10.12 108 100200 17525 32395693
Amoebiasis 20.47 10.12 8 100300 68 32413150
Torulopsis infection 20.44 10.12 6 100302 18 32413200
Therapy cessation 20.43 10.12 12 100296 16001 32397217
Urine analysis abnormal 20.42 10.12 28 100280 1981 32411237
Cavernous sinus thrombosis 20.35 10.12 10 100298 154 32413064
Pain in extremity 20.28 10.12 252 100056 118649 32294569
Complications of transplant surgery 20.24 10.12 15 100293 501 32412717
Unresponsive to stimuli 19.97 10.12 34 100274 27575 32385643
Cutaneous malacoplakia 19.86 10.12 7 100301 43 32413175
Product substitution issue 19.86 10.12 4 100304 10432 32402786
Hepatitis E 19.85 10.12 26 100282 1760 32411458
Poisoning 19.78 10.12 5 100303 11153 32402065
Neuroleptic malignant syndrome 19.78 10.12 15 100293 17480 32395738
Multi-organ disorder 19.72 10.12 22 100286 1259 32411959
Intentional product misuse 19.70 10.12 52 100256 35999 32377219
Osteoporosis 19.57 10.12 82 100226 12100 32401118
Laboratory test abnormal 19.56 10.12 18 100290 19069 32394149
Bordetella infection 19.53 10.12 9 100299 119 32413099
Listeria sepsis 19.52 10.12 10 100298 169 32413049
Necrosis ischaemic 19.42 10.12 11 100297 229 32412989
Escherichia sepsis 19.36 10.12 42 100266 4306 32408912
Bursitis infective 19.34 10.12 15 100293 537 32412681
Pruritus 19.33 10.12 280 100028 128422 32284796
Pneumonia adenoviral 19.31 10.12 10 100298 173 32413045
Marrow hyperplasia 19.30 10.12 20 100288 1052 32412166
Red blood cell schistocytes present 19.17 10.12 12 100296 302 32412916
Ophthalmoplegia 19.12 10.12 23 100285 1428 32411790
Irritability 19.11 10.12 29 100279 24625 32388593
Cytomegalovirus nephritis 19.01 10.12 9 100299 127 32413091
Herpes simplex hepatitis 18.91 10.12 8 100300 85 32413133
Cytomegalovirus gastrointestinal infection 18.86 10.12 10 100298 182 32413036
IgA nephropathy 18.83 10.12 20 100288 1083 32412135
Trichophytosis 18.82 10.12 12 100296 312 32412906
Haemolytic anaemia 18.82 10.12 74 100234 10610 32402608
Exposure during pregnancy 18.73 10.12 3 100305 9226 32403992
Staphylococcal infection 18.61 10.12 167 100141 32272 32380946
Lymphocele 18.53 10.12 23 100285 1475 32411743
Hepatitis A 18.40 10.12 14 100294 487 32412731
Central nervous system infection 18.39 10.12 15 100293 578 32412640
Pancytopenia 18.39 10.12 389 99919 90846 32322372
Loss of consciousness 18.27 10.12 165 100143 82542 32330676
Hypersomnia 18.27 10.12 7 100301 11954 32401264
Megacolon 18.19 10.12 25 100283 1773 32411445
Disseminated trichosporonosis 18.18 10.12 7 100301 57 32413161
Psoriatic arthropathy 18.12 10.12 17 100291 17843 32395375
Limbic encephalitis 18.04 10.12 12 100296 336 32412882
Immune-mediated enterocolitis 18.03 10.12 24 100284 1651 32411567
Haemodynamic instability 17.99 10.12 64 100244 8747 32404471
Graft infection 17.97 10.12 13 100295 418 32412800
Medication error 17.96 10.12 26 100282 22509 32390709
Smooth muscle cell neoplasm 17.89 10.12 9 100299 146 32413072
Cutaneous nocardiosis 17.89 10.12 9 100299 146 32413072
Quadriplegia 17.78 10.12 24 100284 1673 32411545
Granuloma 17.78 10.12 31 100277 2704 32410514
Hyperkalaemia 17.75 10.12 134 100174 69616 32343602
Swollen tongue 17.71 10.12 10 100298 13629 32399589
Viral cardiomyopathy 17.58 10.12 6 100302 33 32413185
Abdominal discomfort 17.56 10.12 93 100215 52531 32360687
Herpes simplex colitis 17.56 10.12 5 100303 13 32413205
B-lymphocyte count decreased 17.54 10.12 14 100294 523 32412695
Full blood count decreased 17.48 10.12 16 100292 16994 32396224
Central nervous system vasculitis 17.42 10.12 13 100295 439 32412779
Wheezing 17.39 10.12 57 100251 36817 32376401
Pleural mass 17.38 10.12 7 100301 65 32413153
Adenoviral haemorrhagic cystitis 17.37 10.12 13 100295 441 32412777
Lymphangitis 17.33 10.12 14 100294 532 32412686
Injection site reaction 17.29 10.12 7 100301 11562 32401656
Acute endocarditis 17.29 10.12 5 100303 14 32413204
Orthostatic hypotension 17.28 10.12 33 100275 25617 32387601
Heart rate decreased 17.26 10.12 135 100173 25065 32388153
Steroid withdrawal syndrome 17.25 10.12 10 100298 218 32413000
Sedation 17.24 10.12 19 100289 18507 32394711
Gastritis fungal 17.21 10.12 8 100300 108 32413110
Lymphocyte percentage decreased 17.19 10.12 27 100281 2160 32411058
Dehiscence 17.19 10.12 7 100301 67 32413151
Cerebral venous thrombosis 17.17 10.12 15 100293 636 32412582
Hypophagia 17.17 10.12 29 100279 23594 32389624
Acne fulminans 17.16 10.12 9 100299 160 32413058
Pneumonia escherichia 17.11 10.12 12 100296 367 32412851
Dyspepsia 17.08 10.12 49 100259 33006 32380212
Eschar 16.97 10.12 15 100293 646 32412572
Disseminated tuberculosis 16.94 10.12 27 100281 2187 32411031
Post procedural urine leak 16.86 10.12 9 100299 166 32413052
Urobilinogen urine increased 16.80 10.12 12 100296 378 32412840
Necrosis 16.75 10.12 46 100262 5473 32407745
Intestine transplant rejection 16.74 10.12 6 100302 39 32413179
Uraemic encephalopathy 16.73 10.12 11 100297 302 32412916
Enterococcus test positive 16.68 10.12 17 100291 877 32412341
Haematopoietic stem cell mobilisation 16.67 10.12 9 100299 170 32413048
Bifidobacterium infection 16.57 10.12 5 100303 17 32413201
Necrotising oesophagitis 16.55 10.12 14 100294 568 32412650
Arteriosclerosis coronary artery 16.48 10.12 8 100300 11873 32401345
Cytokine release syndrome 16.48 10.12 84 100224 13451 32399767
Arterial spasm 16.46 10.12 8 100300 120 32413098
Peritonitis bacterial 16.46 10.12 9 100299 12487 32400731
Endocarditis 16.36 10.12 51 100257 6513 32406705
Blood pressure diastolic increased 16.35 10.12 35 100273 3555 32409663
Chemotherapeutic drug level above therapeutic 16.35 10.12 5 100303 18 32413200
Blood sodium decreased 16.34 10.12 16 100292 16458 32396760
Cerebral fungal infection 16.32 10.12 10 100298 242 32412976
Chimerism 16.29 10.12 10 100298 243 32412975
Kidney rupture 16.29 10.12 10 100298 243 32412975
Herpes zoster cutaneous disseminated 16.26 10.12 9 100299 179 32413039
Fungal endocarditis 16.25 10.12 10 100298 244 32412974
Respiratory disorder 16.16 10.12 109 100199 19308 32393910
Disseminated varicella zoster virus infection 16.15 10.12 18 100290 1029 32412189
Activated partial thromboplastin time shortened 16.14 10.12 13 100295 492 32412726
Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids 16.14 10.12 5 100303 19 32413199
Peritoneal candidiasis 16.14 10.12 5 100303 19 32413199
Colitis 16.14 10.12 168 100140 33783 32379435
Autoimmune hepatitis 16.13 10.12 37 100271 3938 32409280
Injection site erythema 16.04 10.12 13 100295 14655 32398563
Heart transplant rejection 16.01 10.12 20 100288 1291 32411927
Ureteric anastomosis complication 16.00 10.12 6 100302 45 32413173
Engraftment syndrome 16.00 10.12 17 100291 921 32412297
Angina pectoris 15.93 10.12 47 100261 31379 32381839
Foetal growth restriction 15.90 10.12 37 100271 3975 32409243
Leishmaniasis 15.84 10.12 11 100297 331 32412887
Encephalitis fungal 15.78 10.12 9 100299 190 32413028
Disseminated varicella zoster vaccine virus infection 15.78 10.12 6 100302 47 32413171
Splenic necrosis 15.78 10.12 6 100302 47 32413171
Accelerated idioventricular rhythm 15.72 10.12 7 100301 85 32413133
Injection site swelling 15.69 10.12 5 100303 9579 32403639
Meningitis fungal 15.68 10.12 8 100300 134 32413084
Pneumonia influenzal 15.62 10.12 21 100287 1458 32411760
Subcapsular renal haematoma 15.61 10.12 12 100296 424 32412794
Blood immunoglobulin G decreased 15.59 10.12 19 100289 1196 32412022
Spermatozoa progressive motility decreased 15.57 10.12 8 100300 136 32413082
Blood pressure decreased 15.56 10.12 93 100215 50987 32362231
Gastrointestinal perforation 15.55 10.12 36 100272 3854 32409364
Fluid retention 15.52 10.12 37 100271 26513 32386705
Oral herpes 15.51 10.12 42 100266 4955 32408263
Subcutaneous emphysema 15.48 10.12 18 100290 1078 32412140
Paranoia 15.40 10.12 7 100301 10792 32402426
Dysgeusia 15.39 10.12 35 100273 25496 32387722
Encephalitis brain stem 15.37 10.12 7 100301 90 32413128
Herpes zoster 15.35 10.12 160 100148 32181 32381037
Pancreas transplant rejection 15.33 10.12 9 100299 201 32413017
Hepatitis cholestatic 15.33 10.12 58 100250 8167 32405051
Arteritis coronary 15.25 10.12 6 100302 52 32413166
Peliosis hepatis 15.25 10.12 6 100302 52 32413166
Small intestinal perforation 15.25 10.12 23 100285 1776 32411442
Miosis 15.24 10.12 4 100304 8700 32404518
West Nile viral infection 15.23 10.12 14 100294 635 32412583
Tularaemia 15.23 10.12 7 100301 92 32413126
Glomerulonephritis minimal lesion 15.15 10.12 12 100296 443 32412775
Wolff-Parkinson-White syndrome 15.10 10.12 9 100299 207 32413011
Lymphocytosis 15.09 10.12 25 100283 2092 32411126
Systemic lupus erythematosus 15.06 10.12 30 100278 2896 32410322
Secondary immunodeficiency 15.01 10.12 11 100297 361 32412857
Acute myocardial infarction 14.97 10.12 104 100204 55045 32358173
Organising pneumonia 14.96 10.12 45 100263 5636 32407582
Coma 14.96 10.12 74 100234 42538 32370680
Herpes virus infection 14.92 10.12 29 100279 2749 32410469
Abnormal dreams 14.87 10.12 4 100304 8560 32404658
Osteonecrosis 14.86 10.12 95 100213 16527 32396691
Scedosporium infection 14.84 10.12 16 100292 881 32412337
Autoimmune haemolytic anaemia 14.84 10.12 38 100270 4336 32408882
Vision blurred 14.79 10.12 78 100230 44108 32369110
Optic nerve compression 14.77 10.12 4 100304 8 32413210
Myoclonus 14.75 10.12 14 100294 14615 32398603
Pupils unequal 14.70 10.12 20 100288 1405 32411813
Visceral leishmaniasis 14.67 10.12 13 100295 562 32412656
Arthritis fungal 14.65 10.12 7 100301 101 32413117
Acanthamoeba keratitis 14.65 10.12 7 100301 101 32413117
Biopsy lymph gland 14.50 10.12 6 100302 60 32413158
Hypotension 14.50 10.12 533 99775 215577 32197641
Thyroiditis subacute 14.43 10.12 5 100303 29 32413189
Skin discolouration 14.42 10.12 18 100290 16595 32396623
Intentional self-injury 14.37 10.12 13 100295 13887 32399331
Sleep disorder 14.31 10.12 39 100269 26713 32386505
Diffuse mesangial sclerosis 14.28 10.12 5 100303 30 32413188
Immune thrombocytopenia 14.28 10.12 58 100250 8439 32404779
Encephalitis 14.24 10.12 51 100257 6993 32406225
Steroid dependence 14.24 10.12 8 100300 164 32413054
Diarrhoea haemorrhagic 14.23 10.12 47 100261 6188 32407030
Arterial rupture 14.22 10.12 12 100296 485 32412733
Pneumonia klebsiella 14.16 10.12 29 100279 2856 32410362
Adverse event 14.14 10.12 18 100290 16454 32396764
Pneumonia bacterial 14.11 10.12 68 100240 10648 32402570
Pulmonary haemorrhage 14.04 10.12 64 100244 9793 32403425
Tubulointerstitial nephritis 14.03 10.12 106 100202 19471 32393747
Gastrointestinal ulcer 14.00 10.12 22 100286 1761 32411457
Acinetobacter bacteraemia 13.95 10.12 7 100301 113 32413105
Chronic papillomatous dermatitis 13.92 10.12 6 100302 67 32413151
Crystal urine present 13.82 10.12 11 100297 409 32412809
Systemic inflammatory response syndrome 13.80 10.12 49 100259 6691 32406527
Dry mouth 13.79 10.12 34 100274 24085 32389133
Semen volume decreased 13.76 10.12 10 100298 324 32412894
Granulomatous liver disease 13.76 10.12 13 100295 611 32412607
Blood immunoglobulin M decreased 13.73 10.12 11 100297 413 32412805
Stenotrophomonas infection 13.66 10.12 22 100286 1798 32411420
Salivary hypersecretion 13.63 10.12 4 100304 8084 32405134
Pneumonia necrotising 13.53 10.12 13 100295 624 32412594
Pericarditis fungal 13.46 10.12 8 100300 183 32413035
Muscle rigidity 13.42 10.12 9 100299 11177 32402041
Incorrect dose administered 13.37 10.12 59 100249 34969 32378249
Alveolar proteinosis 13.36 10.12 10 100298 339 32412879
Pneumonitis 13.34 10.12 147 100161 29987 32383231
Epstein-Barr virus test positive 13.32 10.12 12 100296 530 32412688
Epididymitis 13.28 10.12 26 100282 2478 32410740
Palatal ulcer 13.28 10.12 5 100303 38 32413180
Vitamin B1 decreased 13.22 10.12 9 100299 262 32412956
Herpes simplex meningoencephalitis 13.16 10.12 4 100304 14 32413204
Congenital cardiovascular anomaly 13.15 10.12 8 100300 191 32413027
Kaposi's sarcoma 13.14 10.12 16 100292 1006 32412212
Bacterial infection 13.12 10.12 81 100227 13925 32399293
Urinary fistula 13.07 10.12 7 100301 130 32413088
Urinary tract infection bacterial 13.06 10.12 20 100288 1565 32411653
Thrombosis 13.06 10.12 85 100223 45669 32367549
Radiotherapy to brain 13.06 10.12 5 100303 40 32413178
Faeces discoloured 13.04 10.12 16 100292 14861 32398357
Meningitis cryptococcal 13.03 10.12 24 100284 2185 32411033
Drug intolerance 13.02 10.12 96 100212 50139 32363079
Febrile bone marrow aplasia 13.02 10.12 56 100252 8359 32404859
Encephalitis cytomegalovirus 13.00 10.12 12 100296 547 32412671
Splenic infection fungal 12.98 10.12 6 100302 80 32413138
Glycosylated haemoglobin increased 12.95 10.12 8 100300 10381 32402837
Meconium peritonitis 12.95 10.12 4 100304 15 32413203
Blindness cortical 12.94 10.12 10 100298 356 32412862
Hypertension 12.94 10.12 513 99795 131237 32281981
Serum sickness 12.94 10.12 22 100286 1881 32411337
Mucosal ulceration 12.93 10.12 15 100293 896 32412322
Transaminases increased 12.93 10.12 126 100182 24902 32388316
Multiple sclerosis relapse 12.89 10.12 71 100237 11710 32401508
Neuropathy peripheral 12.80 10.12 164 100144 76818 32336400
Drug withdrawal syndrome 12.80 10.12 27 100281 20204 32393014
Neurological symptom 12.77 10.12 32 100276 3603 32409615
Venoocclusive disease 12.77 10.12 27 100281 2719 32410499
Malignant neoplasm progression 12.76 10.12 168 100140 78328 32334890
Carotid artery insufficiency 12.75 10.12 4 100304 16 32413202
Phaeohyphomycotic brain abscess 12.75 10.12 5 100303 43 32413175
Abdominal infection 12.74 10.12 20 100288 1599 32411619
Akathisia 12.74 10.12 3 100305 7022 32406196
Bacillus infection 12.73 10.12 9 100299 279 32412939
Gastroenteritis rotavirus 12.72 10.12 8 100300 203 32413015
Hypertensive encephalopathy 12.70 10.12 10 100298 366 32412852
Epstein Barr virus positive mucocutaneous ulcer 12.64 10.12 9 100299 282 32412936
Coombs direct test positive 12.59 10.12 9 100299 284 32412934
Pleuropericarditis 12.58 10.12 8 100300 207 32413011
Lung transplant rejection 12.57 10.12 14 100294 800 32412418
Neutrophil count increased 12.55 10.12 89 100219 16025 32397193
Amoebic dysentery 12.55 10.12 5 100303 45 32413173
Pelvic venous thrombosis 12.54 10.12 12 100296 573 32412645
White blood cell count decreased 12.45 10.12 202 100106 90996 32322222
Morganella infection 12.44 10.12 11 100297 474 32412744
Hemianopia 12.43 10.12 13 100295 691 32412527
Fear 12.42 10.12 10 100298 11309 32401909
Dyspnoea exertional 12.37 10.12 70 100238 38891 32374327
Autoimmune thyroiditis 12.36 10.12 16 100292 1071 32412147
Papillary muscle rupture 12.28 10.12 3 100305 3 32413215
Neonatal multi-organ failure 12.28 10.12 3 100305 3 32413215
Hypoaesthesia 12.20 10.12 118 100190 58235 32354983
Lipoma 12.20 10.12 19 100289 1509 32411709
Inhibin B 12.20 10.12 4 100304 19 32413199
Colorectal adenocarcinoma 12.19 10.12 8 100300 219 32412999
Lymphocytic infiltration 12.18 10.12 13 100295 708 32412510
Fungal abscess central nervous system 12.17 10.12 6 100302 93 32413125
Fungal sepsis 12.17 10.12 15 100293 955 32412263
Brain oedema 12.17 10.12 75 100233 12885 32400333
Electrocardiogram QT prolonged 12.17 10.12 72 100236 39569 32373649
Henoch-Schonlein purpura 12.15 10.12 20 100288 1665 32411553
Lower gastrointestinal haemorrhage 12.14 10.12 6 100302 8811 32404407
Exophthalmos 12.13 10.12 12 100296 597 32412621
Acute kidney injury 12.11 10.12 762 99546 292706 32120512
Premature baby 12.02 10.12 98 100210 18420 32394798
Viral load abnormal 12.00 10.12 6 100302 96 32413122
Multiple-drug resistance 11.99 10.12 32 100276 3743 32409475
Therapeutic product effect decreased 11.99 10.12 52 100256 30965 32382253
Cardiac failure 11.88 10.12 205 100103 91468 32321750
Myocarditis infectious 11.87 10.12 4 100304 21 32413197
Chronic hepatitis 11.87 10.12 12 100296 613 32412605
Pollakiuria 11.87 10.12 25 100283 18719 32394499
Papilloedema 11.85 10.12 25 100283 2513 32410705
Microsporidia infection 11.84 10.12 12 100296 615 32412603
Necrotising soft tissue infection 11.83 10.12 5 100303 53 32413165
Intestinal ulcer 11.82 10.12 14 100294 855 32412363
Drug eruption 11.77 10.12 26 100282 19140 32394078
Rash papulosquamous 11.75 10.12 5 100303 54 32413164
Panic attack 11.73 10.12 7 100301 9254 32403964
Tumefactive multiple sclerosis 11.72 10.12 4 100304 22 32413196
Post procedural bile leak 11.71 10.12 9 100299 318 32412900
Cytomegalovirus gastritis 11.69 10.12 8 100300 235 32412983
Memory impairment 11.65 10.12 75 100233 40404 32372814
Drug effective for unapproved indication 11.64 10.12 18 100290 1421 32411797
Central nervous system lesion 11.60 10.12 42 100266 5790 32407428
Viral sepsis 11.59 10.12 5 100303 56 32413162
Abscess sterile 11.57 10.12 4 100304 23 32413195
Injection site haemorrhage 11.44 10.12 6 100302 8522 32404696
Bronchitis bacterial 11.43 10.12 13 100295 760 32412458
Idiopathic pneumonia syndrome 11.43 10.12 8 100300 244 32412974
Periventricular haemorrhage neonatal 11.43 10.12 4 100304 24 32413194
Eye abscess 11.40 10.12 7 100301 170 32413048
Urinary retention 11.40 10.12 64 100244 35633 32377585
Adenomatous polyposis coli 11.40 10.12 7 100301 170 32413048
Blood glucose decreased 11.40 10.12 15 100293 13519 32399699
Ageusia 11.38 10.12 8 100300 9694 32403524
Pseudomonal bacteraemia 11.38 10.12 15 100293 1022 32412196
Rash 11.34 10.12 529 99779 208804 32204414
Respiratory distress 11.33 10.12 162 100146 35084 32378134
ADAMTS13 activity decreased 11.32 10.12 6 100302 109 32413109
Hypocalcaemia 11.31 10.12 35 100273 23019 32390199
Renal cancer recurrent 11.29 10.12 4 100304 25 32413193
Emphysematous cystitis 11.28 10.12 5 100303 60 32413158
Eosinophil percentage decreased 11.27 10.12 6 100302 110 32413108
Encephalopathy 11.24 10.12 158 100150 34099 32379119
Mycobacterium kansasii infection 11.23 10.12 8 100300 251 32412967
Donor specific antibody present 11.23 10.12 6 100302 111 32413107
Erythema infectiosum 11.22 10.12 7 100301 175 32413043
Body height below normal 11.20 10.12 8 100300 252 32412966
Polyomavirus viraemia 11.19 10.12 12 100296 657 32412561
Trichosporon infection 11.13 10.12 13 100295 782 32412436
Glomerulonephritis rapidly progressive 11.12 10.12 11 100297 547 32412671
Hypercapnia 11.12 10.12 33 100275 4102 32409116
Pulmonary fibrosis 11.11 10.12 90 100218 16884 32396334
Chorioretinal folds 11.08 10.12 3 100305 6 32413212
Perinephric collection 11.02 10.12 7 100301 181 32413037
Enterobacter bacteraemia 11.01 10.12 9 100299 348 32412870
Disturbance in attention 11.00 10.12 37 100271 23716 32389502
Viral haemorrhagic cystitis 11.00 10.12 14 100294 921 32412297
Hepatic cirrhosis 11.00 10.12 22 100286 16787 32396431
Sarcopenia 10.99 10.12 9 100299 349 32412869
Thyrotoxic periodic paralysis 10.93 10.12 5 100303 65 32413153
Amnesia 10.93 10.12 40 100268 24996 32388222
Enterococcal sepsis 10.92 10.12 19 100289 1654 32411564
Venous haemorrhage 10.91 10.12 4 100304 28 32413190
Paraneoplastic neurological syndrome 10.91 10.12 4 100304 28 32413190
Gait inability 10.89 10.12 29 100279 20018 32393200
Poikiloderma 10.88 10.12 7 100301 185 32413033
Thyroid gland abscess 10.86 10.12 5 100303 66 32413152
Adverse drug reaction 10.84 10.12 42 100266 25819 32387399
Hilar lymphadenopathy 10.82 10.12 14 100294 936 32412282
New onset diabetes after transplantation 10.79 10.12 4 100304 29 32413189
Restless legs syndrome 10.78 10.12 5 100303 7619 32405599
Haematuria traumatic 10.78 10.12 7 100301 188 32413030
Acinetobacter test positive 10.76 10.12 6 100302 121 32413097
Immune-mediated myocarditis 10.75 10.12 8 100300 269 32412949
Candida sepsis 10.73 10.12 16 100292 1223 32411995
Ureaplasma infection 10.72 10.12 7 100301 190 32413028
Gastrooesophageal reflux disease 10.71 10.12 63 100245 34675 32378543
Glucose tolerance impaired 10.68 10.12 27 100281 3056 32410162
Bacterial pyelonephritis 10.65 10.12 8 100300 273 32412945
Hypoacusis 10.64 10.12 20 100288 15621 32397597
Unmasking of previously unidentified disease 10.61 10.12 12 100296 697 32412521
Dental caries 10.59 10.12 35 100273 4609 32408609
Pulmonary granuloma 10.59 10.12 17 100291 1386 32411832
Cardio-respiratory arrest 10.56 10.12 116 100192 55873 32357345
Optic atrophy 10.53 10.12 13 100295 829 32412389
Gastrointestinal wall thickening 10.53 10.12 15 100293 1100 32412118
Eye luxation 10.48 10.12 3 100305 8 32413210
Right ventricular diastolic collapse 10.47 10.12 5 100303 72 32413146
Ventricular extrasystoles 10.47 10.12 13 100295 12013 32401205
Diabetic ketoacidosis 10.47 10.12 25 100283 17907 32395311
Polychromasia 10.46 10.12 6 100302 128 32413090
Tricuspid valve incompetence 10.45 10.12 8 100300 9279 32403939
Dysstasia 10.45 10.12 12 100296 11474 32401744
Gastric perforation 10.44 10.12 22 100286 2211 32411007
Gastrointestinal haemorrhage 10.40 10.12 197 100111 86685 32326533
Haptoglobin decreased 10.39 10.12 11 100297 593 32412625
Acanthamoeba infection 10.37 10.12 10 100298 482 32412736
Executive dysfunction 10.37 10.12 7 100301 201 32413017
Neuromyotonia 10.34 10.12 4 100304 33 32413185
Urine bilirubin decreased 10.34 10.12 4 100304 33 32413185
Refractory cancer 10.34 10.12 6 100302 131 32413087
Road traffic accident 10.33 10.12 24 100284 17357 32395861
Eczema 10.33 10.12 19 100289 14961 32398257
Large granular lymphocytosis 10.28 10.12 7 100301 204 32413014
Seizure 10.24 10.12 243 100065 103611 32309607
Blood 1,25-dihydroxycholecalciferol increased 10.22 10.12 3 100305 9 32413209
Rhinocerebral mucormycosis 10.22 10.12 6 100302 134 32413084
Epstein-Barr virus infection reactivation 10.20 10.12 10 100298 492 32412726
Hyponatraemia 10.19 10.12 165 100143 74348 32338870
Capillaritis 10.18 10.12 6 100302 135 32413083
Hepatic encephalopathy 10.18 10.12 19 100289 14876 32398342
Neuromyopathy 10.17 10.12 14 100294 994 32412224
Blood potassium increased 10.15 10.12 23 100285 16781 32396437
Disseminated cryptococcosis 10.13 10.12 15 100293 1139 32412079
Rhinovirus infection 10.12 10.12 28 100280 3345 32409873

Pharmacologic Action:

SourceCodeDescription
ATC D07AA01 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, PLAIN
Corticosteroids, weak (group I)
ATC D10AA02 DERMATOLOGICALS
ANTI-ACNE PREPARATIONS
ANTI-ACNE PREPARATIONS FOR TOPICAL USE
Corticosteroids, combinations for treatment of acne
ATC H02AB04 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
CORTICOSTEROIDS FOR SYSTEMIC USE
CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
Glucocorticoids
ATC D07CA02 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, COMBINATIONS WITH ANTIBIOTICS
Corticosteroids, weak, combinations with antibiotics
ATC H02BX01 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
CORTICOSTEROIDS FOR SYSTEMIC USE
CORTICOSTEROIDS FOR SYSTEMIC USE, COMBINATIONS
Corticosteroids for systemic use, combinations
ATC S01CA08 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids and antiinfectives in combination
FDA MoA N0000175450 Corticosteroid Hormone Receptor Agonists
FDA EPC N0000175576 Corticosteroid
MeSH PA D006728 Hormones
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000932 Antiemetics
MeSH PA D002491 Central Nervous System Agents
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D005938 Glucocorticoids
MeSH PA D018696 Neuroprotective Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D020011 Protective Agents
CHEBI has role CHEBI:35472 anti-inflammatory drugs
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:37962 adrenergic neuron agents
CHEBI has role CHEBI:50919 antiemetico
CHEBI has role CHEBI:63726 neuroprotective agents
CHEBI has role CHEBI:78298 environmental contaminants

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Disorder of musculoskeletal system indication 928000 DOID:17
Cerebral edema indication 2032001
Berylliosis indication 8247009 DOID:10322
Psoriasis indication 9014002 DOID:8893
Ankylosing spondylitis indication 9631008 DOID:7147
Rheumatic heart disease indication 23685000
Atopic dermatitis indication 24079001 DOID:3310
Inflammatory bowel disease indication 24526004 DOID:0050589
Multiple sclerosis indication 24700007 DOID:2377
Severe adrenal insufficiency indication 24867002
Sarcoidosis indication 31541009 DOID:11335
Idiopathic thrombocytopenic purpura indication 32273002 DOID:8924
Psoriasis with arthropathy indication 33339001
Crohn's disease indication 34000006
Tendinitis indication 34840004 DOID:971
Erythema multiforme indication 36715001
Contact dermatitis indication 40275004 DOID:2773
Angioedema indication 41291007 DOID:1558
Miliary tuberculosis indication 47604008 DOID:9861
Humoral hypercalcemia of malignancy indication 47709007
Articular gout indication 48440001 DOID:13189
Seborrheic dermatitis indication 50563003 DOID:8741
Edema of larynx indication 51599000
Nephrotic syndrome indication 52254009 DOID:1184
Lichen simplex chronicus indication 53891004
Systemic lupus erythematosus indication 55464009 DOID:9074
Allergic rhinitis indication 61582004
Löffler's syndrome indication 64936001 DOID:9503
Pemphigus indication 65172003 DOID:9182
Granuloma annulare indication 65508009 DOID:3777
Tenosynovitis indication 67801009 DOID:970
Rheumatoid arthritis indication 69896004 DOID:7148
Transfusion reaction due to serum protein reaction indication 72284000
Epicondylitis indication 73583000 DOID:14087
Acquired thrombocytopenia indication 74576004 DOID:11126
Thyroiditis indication 82119001 DOID:7166
Bursitis indication 84017003 DOID:2965
Autoimmune disease indication 85828009
Infection by larvae of Trichinella spiralis indication 88264003
Congenital hypoplastic anemia indication 88854002 DOID:1339
Pruritus ani indication 90446007
Acute lymphoid leukemia indication 91857003 DOID:9952
Disorder of skin indication 95320005 DOID:37
Dermatitis herpetiformis indication 111196000 DOID:8505
Hodgkin's disease indication 118599009
Non-Hodgkin's lymphoma indication 118601006
Mycosis fungoides indication 118618005
Aspiration pneumonitis indication 155597006
Asthma indication 195967001 DOID:2841
Discoid lupus erythematosus indication 200938002
Plaque psoriasis indication 200965009
Transplanted organ rejection indication 213148006
Congenital adrenal hyperplasia indication 237751000
Scalp psoriasis indication 238608008
Adrenogenital disorder indication 267395000 DOID:0050811
Pruritus of genital organs indication 267802000
Eruption of skin indication 271807003 DOID:0050486
Exacerbation of asthma indication 281239006
Follicular non-Hodgkin's lymphoma indication 308121000
Disorder of eye indication 371405004 DOID:5614
Primary adrenocortical insufficiency indication 373662000
Adrenal cortical hypofunction indication 386584007 DOID:10493
Erythroderma indication 399992009
Primary cutaneous T-cell lymphoma indication 400122007
Juvenile rheumatoid arthritis indication 410795001
Autoimmune hemolytic anemia indication 413603009 DOID:718
Synovitis indication 416209007 DOID:2703
Post traumatic osteoarthritis indication 699262001
Systemic Dermatomyositis indication
Diagnostic Test for Cushing's Syndrome indication
Synovitis due to Osteoarthritis indication
Transfusion Reaction Urticaria indication
Progressive Diffuse Large B-Cell Lymphoma indication
Erythroblastic Anemia indication
Pericarditis off-label use 3238004 DOID:1787
Chronic obstructive lung disease off-label use 13645005 DOID:3083
Pulmonary edema off-label use 19242006 DOID:11396
Shock off-label use 27942005
West syndrome off-label use 28055006
Vasculitis off-label use 31996006 DOID:865
Bronchitis off-label use 32398004 DOID:6132
Anaphylaxis off-label use 39579001
Eczema off-label use 43116000
Respiratory distress syndrome in the newborn off-label use 46775006
Nasal polyp off-label use 52756005
Rheumatic fever off-label use 58718002 DOID:1586
Pseudogout off-label use 60782007
Polymyalgia rheumatica off-label use 65323003 DOID:853
Chronic hepatitis off-label use 76783007 DOID:2237
Pemphigoid off-label use 86142006
Hepatic necrosis off-label use 87248009
Multiple myeloma off-label use 109989006 DOID:9538
Polyarteritis nodosa off-label use 155441006 DOID:9810
Coronavirus infection off-label use 186747009
Celiac disease off-label use 396331005 DOID:10608
Carditis off-label use 399617002
Giant cell arteritis off-label use 414341000 DOID:13375
Neonatal Bronchopulmonary Dysplasia off-label use
Prevention of Post-Extubation Laryngeal Edema off-label use
Metastatic Prostate Carcinoma off-label use
Hypercalcemia associated with Sarcoidosis off-label use
Neuroendocrine Prostate Carcinoma off-label use
Prevention of Lung Transplant Rejection off-label use
Prevention of Cardiac Transplant Rejection off-label use
Infection by Strongyloides contraindication 1214006 DOID:10955
Mycosis contraindication 3218000 DOID:1564
Gastritis contraindication 4556007 DOID:4029
Inactive tuberculosis contraindication 11999007
Peptic ulcer contraindication 13200003 DOID:750
Hypercholesterolemia contraindication 13644009
Measles contraindication 14189004 DOID:8622
Cirrhosis of liver contraindication 19943007 DOID:5082
Arginase deficiency contraindication 23501004 DOID:9278
Immunosuppression contraindication 38013005
Hypertensive disorder contraindication 38341003 DOID:10763
Infectious disease contraindication 40733004
Hypothyroidism contraindication 40930008 DOID:1459
Hypokalemia contraindication 43339004
Chronic heart failure contraindication 48447003
Cerebral malaria contraindication 53622003 DOID:14069
Tuberculosis contraindication 56717001
Congenital hyperammonemia, type I contraindication 62522004
Osteoporosis contraindication 64859006 DOID:11476
Psychotic disorder contraindication 69322001
Diabetes mellitus contraindication 73211009 DOID:9351
Hypopituitarism contraindication 74728003 DOID:9406
Hyperglycemia contraindication 80394007 DOID:4195
Open-angle glaucoma contraindication 84494001 DOID:1067
Muscle atrophy contraindication 88092000 DOID:767
Herpes simplex contraindication 88594005 DOID:8566
Bilateral cataracts contraindication 95722004
Seizure disorder contraindication 128613002
Disorder of muscle contraindication 129565002 DOID:423
Ophthalmic herpes simplex contraindication 186542001
Skin striae contraindication 201066002
Anastomosis of intestine contraindication 235407009
Telangiectasia disorder contraindication 247479008
Edema contraindication 267038008
Pathological fracture contraindication 268029009
Diverticulitis of gastrointestinal tract contraindication 271366000
Cerebral trauma contraindication 275382005
Pregnancy, function contraindication 289908002
Varicella-zoster virus infection contraindication 309465005
Osteopenia contraindication 312894000
Avascular necrosis of bone contraindication 397758007 DOID:10159
Citrullinemia contraindication 398680004 DOID:9273
Atrophoderma contraindication 399979006
Traumatic rupture of tendon contraindication 415749005
Exposure to varicella contraindication 444453009
Ornithine Carbamyltransferase Deficiency contraindication
Arginosuccinate Lyase Deficiency contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.18 acidic
pKa2 12.89 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST EC50 8.50 WOMBAT-PK CHEMBL
Annexin A1 Cytosolic other WOMBAT-PK
Short transient receptor potential channel 5 Ion channel ACTIVATOR EC50 4.92 IUPHAR
Androgen receptor Transcription factor Ki 4.75 DRUG MATRIX

External reference:

IDSource
4018068 VUID
N0000146409 NUI
D00407 KEGG_DRUG
4018068 VANDF
C0025815 UMLSCUI
CHEBI:6888 CHEBI
CHEMBL1201081 ChEMBL_ID
CHEMBL650 ChEMBL_ID
DB00959 DRUGBANK_ID
D008775 MESH_DESCRIPTOR_UI
6741 PUBCHEM_CID
7088 IUPHAR_LIGAND_ID
732 INN_ID
X4W7ZR7023 UNII
6902 RXNORM
1041 MMSL
5093 MMSL
7130 MMSL
d00293 MMSL
002160 NDDF
116593003 SNOMEDCT_US
27242001 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Medrol HUMAN PRESCRIPTION DRUG LABEL 1 0009-0020 TABLET 2 mg ORAL NDA 16 sections
Medrol HUMAN PRESCRIPTION DRUG LABEL 1 0009-0022 TABLET 8 mg ORAL NDA 16 sections
Medrol HUMAN PRESCRIPTION DRUG LABEL 1 0009-0049 TABLET 2 mg ORAL NDA 16 sections
Medrol HUMAN PRESCRIPTION DRUG LABEL 1 0009-0056 TABLET 4 mg ORAL NDA 16 sections
Medrol HUMAN PRESCRIPTION DRUG LABEL 1 0009-0073 TABLET 16 mg ORAL NDA 16 sections
Medrol HUMAN PRESCRIPTION DRUG LABEL 1 0009-0176 TABLET 32 mg ORAL NDA 16 sections
MethylPREDNISolone HUMAN PRESCRIPTION DRUG LABEL 1 0603-4593 TABLET 4 mg ORAL ANDA 13 sections
Methylprednisolone HUMAN PRESCRIPTION DRUG LABEL 1 0781-5022 TABLET 4 mg ORAL ANDA 15 sections
methylprednisolone HUMAN PRESCRIPTION DRUG LABEL 1 0904-6914 TABLET 4 mg ORAL ANDA 13 sections
METHYLPREDNISOLONE HUMAN PRESCRIPTION DRUG LABEL 1 16590-149 TABLET 4 mg ORAL ANDA 11 sections
Medrol HUMAN PRESCRIPTION DRUG LABEL 1 16590-879 TABLET 4 mg ORAL NDA 11 sections
Methylprednisolone HUMAN PRESCRIPTION DRUG LABEL 1 21695-080 TABLET 4 mg ORAL ANDA 12 sections
Methylprednisolone HUMAN PRESCRIPTION DRUG LABEL 1 33261-335 TABLET 4 mg ORAL ANDA 12 sections
METHYLPREDNISOLONE HUMAN PRESCRIPTION DRUG LABEL 1 42549-522 TABLET 4 mg ORAL ANDA 12 sections
METHYLPREDNISOLONE HUMAN PRESCRIPTION DRUG LABEL 1 42806-400 TABLET 4 mg ORAL ANDA 15 sections
Methylprednisolone HUMAN PRESCRIPTION DRUG LABEL 1 45865-104 TABLET 4 mg ORAL ANDA 15 sections
Methylprednisolone HUMAN PRESCRIPTION DRUG LABEL 1 45865-417 TABLET 4 mg ORAL ANDA 12 sections
Methylprednisolone HUMAN PRESCRIPTION DRUG LABEL 1 49999-153 TABLET 4 mg ORAL NDA 14 sections
Medrol HUMAN PRESCRIPTION DRUG LABEL 1 50090-0092 TABLET 4 mg ORAL NDA 15 sections
Methylprednisolone HUMAN PRESCRIPTION DRUG LABEL 1 50090-3094 TABLET 4 mg ORAL ANDA 12 sections
methylprednisolone HUMAN PRESCRIPTION DRUG LABEL 1 50090-3811 TABLET 4 mg ORAL ANDA 12 sections
Methylprednisolone HUMAN PRESCRIPTION DRUG LABEL 1 50436-0001 TABLET 4 mg ORAL ANDA 12 sections
Methylprednisolone HUMAN PRESCRIPTION DRUG LABEL 1 50436-4037 TABLET 4 mg ORAL ANDA 12 sections
Methylprednisolone HUMAN PRESCRIPTION DRUG LABEL 1 53002-3120 TABLET 4 mg ORAL ANDA 12 sections
Methylprednisolone HUMAN PRESCRIPTION DRUG LABEL 1 54868-2913 TABLET 4 mg ORAL ANDA 11 sections
METHYLPREDNISOLONE HUMAN PRESCRIPTION DRUG LABEL 1 54868-6624 TABLET 4 mg ORAL ANDA 12 sections
MethylPREDNISolone HUMAN PRESCRIPTION DRUG LABEL 1 55045-1259 TABLET 4 mg ORAL ANDA 17 sections
MethylPREDNISolone HUMAN PRESCRIPTION DRUG LABEL 1 55289-649 TABLET 4 mg ORAL ANDA 13 sections
METHYLPREDNISOLONE HUMAN PRESCRIPTION DRUG LABEL 1 57582-101 TABLET 4 mg ORAL ANDA 16 sections
Methylprednisolone HUMAN PRESCRIPTION DRUG LABEL 1 59746-001 TABLET 4 mg ORAL ANDA 12 sections