methylprednisolone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
prednisone and prednisolone derivatives 1768 83-43-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • methylprednisolone
  • medralone
  • metilbetasone
A PREDNISOLONE derivative with similar anti-inflammatory action.
  • Molecular weight: 374.48
  • Formula: C22H30O5
  • CLOGP: 1.74
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 3
  • TPSA: 94.83
  • ALOGS: -3.54
  • ROTB: 2
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
7.50 mg O
20 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.32 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 4.90 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 11.14 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 82 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 1.20 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 6.10 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.23 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2.30 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Oct. 24, 1957 FDA PHARMACIA AND UPJOHN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cytomegalovirus infection 706.83 9.33 526 157947 17436 50429215
Product use in unapproved indication 422.88 9.33 1043 157430 114776 50331875
Completed suicide 355.56 9.33 13 158460 131876 50314775
Infusion related reaction 338.32 9.33 1233 157240 168324 50278327
Off label use 304.37 9.33 2527 155946 471899 49974752
Glossodynia 299.54 9.33 15 158458 115554 50331097
Transplant rejection 251.86 9.33 222 158251 9387 50437264
Pemphigus 251.54 9.33 38 158435 120128 50326523
Death 243.33 9.33 403 158070 324976 50121675
Posterior reversible encephalopathy syndrome 241.66 9.33 265 158208 14663 50431988
Blood pressure fluctuation 227.38 9.33 405 158068 35418 50411233
Aspergillus infection 220.84 9.33 178 158295 6643 50440008
Drug ineffective for unapproved indication 219.65 9.33 301 158172 20980 50425671
Abdominal discomfort 215.19 9.33 245 158228 231396 50215255
Blood pressure diastolic abnormal 194.50 9.33 190 158283 9171 50437480
Urine abnormality 189.79 9.33 157 158316 6081 50440570
Polyomavirus-associated nephropathy 189.33 9.33 94 158379 1458 50445193
Alopecia 189.15 9.33 297 158176 244750 50201901
Haemophagocytic lymphohistiocytosis 180.82 9.33 176 158297 8457 50438194
Bronchopulmonary aspergillosis 180.44 9.33 166 158307 7426 50439225
Multiple organ dysfunction syndrome 174.72 9.33 445 158028 49892 50396759
Oxygen saturation decreased 173.15 9.33 564 157909 72684 50373967
Hand deformity 172.17 9.33 50 158423 100149 50346502
Wound 170.73 9.33 59 158414 105735 50340916
Toxicity to various agents 166.39 9.33 255 158218 212244 50234407
Kidney transplant rejection 161.81 9.33 119 158354 3868 50442783
Contraindicated product administered 160.74 9.33 138 158335 148820 50297831
Systemic lupus erythematosus 159.53 9.33 124 158349 140498 50306153
Blood pressure systolic abnormal 159.33 9.33 156 158317 7550 50439101
Thrombotic microangiopathy 158.05 9.33 165 158308 8626 50438025
BK virus infection 156.86 9.33 103 158370 2778 50443873
Mucormycosis 155.60 9.33 97 158376 2386 50444265
Cytomegalovirus infection reactivation 152.92 9.33 98 158375 2533 50444118
Swelling 152.55 9.33 246 158227 200626 50246025
Lymphocyte count decreased 151.23 9.33 285 158188 26022 50420629
Red blood cells urine positive 148.15 9.33 98 158375 2677 50443974
Nocardiosis 147.67 9.33 82 158391 1616 50445035
Pseudomonas infection 146.76 9.33 164 158309 9266 50437385
Product dose omission issue 146.41 9.33 218 158255 183620 50263031
Pneumocystis jirovecii pneumonia 144.72 9.33 203 158270 14460 50432191
Complications of transplanted kidney 144.08 9.33 88 158385 2085 50444566
Drug intolerance 141.77 9.33 296 158177 218808 50227843
Throat irritation 138.46 9.33 298 158175 29941 50416710
Fall 136.32 9.33 563 157910 334369 50112282
Epstein-Barr virus infection 136.07 9.33 137 158336 6860 50439791
Pericarditis 135.66 9.33 39 158434 78650 50368001
Arthropathy 134.94 9.33 178 158295 157728 50288923
Urine leukocyte esterase positive 132.95 9.33 93 158380 2790 50443861
Enterococcal infection 130.38 9.33 133 158340 6765 50439886
Discomfort 130.13 9.33 90 158383 108290 50338361
White blood cells urine positive 126.48 9.33 109 158364 4469 50442182
Synovitis 126.16 9.33 121 158352 123744 50322907
Cytomegalovirus viraemia 125.82 9.33 110 158363 4599 50442052
Klebsiella infection 123.95 9.33 132 158341 7062 50439589
Varicella zoster virus infection 121.14 9.33 83 158390 2406 50444245
Blood pressure increased 120.95 9.33 772 157701 132360 50314291
Delayed graft function 118.43 9.33 58 158415 872 50445779
Respiratory failure 118.26 9.33 582 157891 90599 50356052
Confusional state 117.88 9.33 254 158219 185674 50260977
Rheumatoid factor positive 116.02 9.33 11 158462 49848 50396803
Irritable bowel syndrome 112.96 9.33 14 158459 51427 50395224
Urinary sediment present 112.85 9.33 73 158400 1918 50444733
Duodenal ulcer perforation 111.83 9.33 8 158465 45603 50401048
Lymphopenia 108.74 9.33 184 158289 15437 50431214
Post transplant lymphoproliferative disorder 105.94 9.33 95 158378 4109 50442542
Anti-cyclic citrullinated peptide antibody positive 104.52 9.33 45 158428 70542 50376109
Injection site pain 104.52 9.33 116 158357 110908 50335743
Erythema 103.63 9.33 799 157674 145615 50301036
Helicobacter infection 103.31 9.33 16 158457 49686 50396965
Steroid diabetes 103.16 9.33 53 158420 887 50445764
Acinetobacter infection 102.92 9.33 61 158412 1366 50445285
Intentional overdose 102.30 9.33 34 158439 62470 50384181
Heart rate decreased 101.02 9.33 297 158176 36200 50410451
Blood pressure diastolic decreased 96.69 9.33 182 158291 16599 50430052
Infective aneurysm 96.45 9.33 39 158434 360 50446291
Progressive multifocal leukoencephalopathy 96.23 9.33 147 158326 11310 50435341
Cushingoid 93.99 9.33 110 158363 6535 50440116
Septic shock 93.58 9.33 391 158082 56784 50389867
Wrong technique in product usage process 92.97 9.33 29 158444 55481 50391170
Adenovirus infection 88.68 9.33 76 158397 3092 50443559
Crystal urine present 88.39 9.33 56 158417 1418 50445233
Muscle injury 86.84 9.33 8 158465 37103 50409548
Drug abuse 85.70 9.33 40 158433 59806 50386845
Reversible cerebral vasoconstriction syndrome 85.44 9.33 63 158410 2056 50444595
Sleep disorder due to general medical condition, insomnia type 85.03 9.33 3 158470 31444 50415207
Electric shock 84.92 9.33 48 158425 980 50445671
Cytomegalovirus test positive 84.67 9.33 68 158405 2524 50444127
Graft versus host disease 83.79 9.33 100 158373 6066 50440585
Acute graft versus host disease in skin 83.66 9.33 72 158401 2946 50443705
Hospitalisation 83.43 9.33 55 158418 67882 50378769
Intervertebral discitis 83.21 9.33 68 158405 2588 50444063
Cardiac failure congestive 82.94 9.33 85 158388 84297 50362354
Pneumomediastinum 82.41 9.33 49 158424 1104 50445547
Blood pressure systolic increased 81.96 9.33 271 158202 35178 50411473
Fatigue 80.96 9.33 1648 156825 705953 49740698
Heart rate increased 80.28 9.33 464 158009 76786 50369865
Disease recurrence 79.73 9.33 187 158286 19894 50426757
Escherichia infection 78.98 9.33 131 158342 10810 50435841
Acute respiratory distress syndrome 78.94 9.33 192 158281 20907 50425744
Folliculitis 78.47 9.33 14 158459 39211 50407440
Graft versus host disease in gastrointestinal tract 78.42 9.33 67 158406 2714 50443937
Acute graft versus host disease in intestine 78.22 9.33 54 158419 1585 50445066
Chorioretinopathy 77.66 9.33 42 158431 784 50445867
Blood urine present 77.46 9.33 142 158331 12691 50433960
Liver transplant rejection 76.64 9.33 49 158424 1261 50445390
Human herpesvirus 6 infection 75.98 9.33 64 158409 2542 50444109
Device expulsion 73.82 9.33 4 158469 28818 50417833
Osteonecrosis 72.90 9.33 194 158279 22323 50424328
Diarrhoea 71.93 9.33 1355 157118 587121 49859530
Thrombocytopenia 71.86 9.33 662 157811 127011 50319640
Ureaplasma infection 71.07 9.33 34 158439 484 50446167
Immunosuppressant drug level increased 70.55 9.33 66 158407 3016 50443635
Viral haemorrhagic cystitis 70.11 9.33 37 158436 656 50445995
Pain 69.81 9.33 1336 157137 577567 49869084
Bacterial test 69.49 9.33 44 158429 1113 50445538
Urine ketone body present 69.48 9.33 58 158415 2275 50444376
Premature delivery 68.79 9.33 196 158277 23467 50423184
Myopathy 68.10 9.33 111 158362 9028 50437623
Product use issue 67.26 9.33 241 158232 149234 50297417
Nausea 66.18 9.33 1694 156779 703704 49742947
Cytomegalovirus chorioretinitis 65.75 9.33 47 158426 1460 50445191
Adverse drug reaction 64.75 9.33 47 158426 55175 50391476
Human herpesvirus 8 infection 64.29 9.33 25 158448 206 50446445
Sepsis 62.52 9.33 664 157809 132261 50314390
Systemic candida 62.43 9.33 59 158414 2731 50443920
Peripheral swelling 62.03 9.33 384 158089 205552 50241099
Vomiting 61.90 9.33 1043 157430 459715 49986936
Adverse event 61.51 9.33 30 158443 43733 50402918
Candida infection 60.91 9.33 187 158286 23336 50423315
Dehydration 60.17 9.33 259 158214 152190 50294461
Drug resistance 59.86 9.33 162 158311 18827 50427824
Knee arthroplasty 59.53 9.33 19 158454 35827 50410824
Stomatitis 58.88 9.33 145 158328 101199 50345452
Red cell distribution width increased 58.49 9.33 100 158373 8459 50438192
Overdose 58.48 9.33 142 158331 99585 50347066
COVID-19 58.44 9.33 295 158178 46367 50400284
Temperature regulation disorder 58.17 9.33 69 158404 4158 50442493
Cytomegalovirus colitis 57.58 9.33 48 158425 1879 50444772
Injection site erythema 57.53 9.33 91 158382 74845 50371806
Mycoplasma infection 57.03 9.33 27 158446 375 50446276
Lupus nephritis 56.95 9.33 52 158421 2303 50444348
Suicide attempt 56.88 9.33 47 158426 51685 50394966
Pneumonia cytomegaloviral 55.22 9.33 47 158426 1894 50444757
Immune thrombocytopenia 54.71 9.33 100 158373 8917 50437734
Pneumatosis intestinalis 53.93 9.33 48 158425 2055 50444596
Loss of personal independence in daily activities 53.84 9.33 85 158388 69965 50376686
Pyrexia 52.85 9.33 1561 156912 378642 50068009
Leukopenia 52.53 9.33 377 158096 67151 50379500
Immunodeficiency 52.37 9.33 132 158341 14696 50431955
Culture urine positive 51.96 9.33 59 158414 3392 50443259
Protein urine present 50.93 9.33 73 158400 5304 50441347
Urine analysis abnormal 50.21 9.33 65 158408 4285 50442366
Drug ineffective 50.18 9.33 3085 155388 816248 49630403
Granulomatosis with polyangiitis 50.01 9.33 43 158430 1757 50444894
Strongyloidiasis 49.93 9.33 32 158441 827 50445824
Neutrophil count increased 49.75 9.33 126 158347 14069 50432582
COVID-19 pneumonia 49.54 9.33 92 158381 8303 50438348
Haemoglobin urine present 49.28 9.33 31 158442 775 50445876
Staphylococcal sepsis 49.13 9.33 83 158390 6953 50439698
Serotonin syndrome 49.04 9.33 9 158464 24704 50421947
Blister 49.00 9.33 123 158350 85295 50361356
Renal transplant failure 48.96 9.33 28 158445 585 50446066
Demyelination 48.76 9.33 76 158397 5950 50440701
Therapeutic product effect decreased 48.42 9.33 240 158233 135810 50310841
Constipation 48.10 9.33 362 158111 185346 50261305
Vasculitis 47.80 9.33 123 158350 13868 50432783
Graft versus host disease in skin 47.79 9.33 49 158424 2507 50444144
Adrenal insufficiency 47.41 9.33 124 158349 14119 50432532
Accidental exposure to product 46.62 9.33 8 158465 23049 50423602
Monocyte count increased 46.42 9.33 71 158402 5468 50441183
Lymphocyte percentage decreased 46.41 9.33 50 158423 2710 50443941
Lower respiratory tract infection 45.86 9.33 149 158324 95052 50351599
Intensive care unit acquired weakness 45.63 9.33 28 158445 669 50445982
Acute graft versus host disease 45.46 9.33 59 158414 3899 50442752
Proteinuria 44.91 9.33 134 158339 16463 50430188
Glomerulonephritis 44.86 9.33 38 158435 1521 50445130
Flushing 44.75 9.33 361 158112 66654 50379997
Pulmonary alveolar haemorrhage 44.65 9.33 59 158414 3968 50442683
Dizziness 44.52 9.33 790 157683 345579 50101072
Mycobacterium abscessus infection 44.42 9.33 25 158448 506 50446145
Herpes simplex 44.18 9.33 80 158393 7082 50439569
Acute graft versus host disease in liver 43.79 9.33 26 158447 584 50446067
Infection reactivation 43.57 9.33 31 158442 956 50445695
Hypogammaglobulinaemia 43.52 9.33 70 158403 5629 50441022
Herpes zoster 43.37 9.33 374 158099 70412 50376239
Disseminated intravascular coagulation 43.23 9.33 135 158338 17000 50429651
Blood pressure diastolic increased 43.22 9.33 81 158392 7362 50439289
Bacterial test positive 43.10 9.33 63 158410 4660 50441991
Status epilepticus 42.88 9.33 115 158358 13291 50433360
Systemic mycosis 42.85 9.33 32 158441 1065 50445586
Listeriosis 42.80 9.33 35 158438 1333 50445318
Rheumatoid arthritis 42.28 9.33 879 157594 201671 50244980
Brain abscess 42.24 9.33 39 158434 1752 50444899
Cystitis haemorrhagic 42.23 9.33 55 158418 3647 50443004
Neutrophil percentage increased 41.70 9.33 47 158426 2680 50443971
Chronic allograft nephropathy 41.62 9.33 26 158447 642 50446009
Sedation 41.49 9.33 22 158451 30588 50416063
Ear pruritus 41.15 9.33 45 158428 2481 50444170
Alveolitis 41.03 9.33 45 158428 2489 50444162
Febrile bone marrow aplasia 40.86 9.33 72 158401 6239 50440412
Central nervous system infection 40.74 9.33 26 158447 667 50445984
Pharyngeal paraesthesia 40.63 9.33 35 158438 1434 50445217
Enterobacter infection 40.49 9.33 39 158434 1849 50444802
Myocardial infarction 40.38 9.33 143 158330 88884 50357767
Depressed level of consciousness 39.96 9.33 63 158410 51890 50394761
Product quality issue 39.22 9.33 24 158449 30834 50415817
Disseminated tuberculosis 39.14 9.33 44 158429 2502 50444149
Symptom masked 39.08 9.33 25 158448 644 50446007
Encephalitis autoimmune 38.97 9.33 32 158441 1226 50445425
Orthostatic hypotension 38.78 9.33 22 158451 29459 50417192
Opportunistic infection 38.54 9.33 36 158437 1642 50445009
International normalised ratio increased 38.52 9.33 47 158426 43105 50403546
JC virus infection 38.00 9.33 37 158436 1778 50444873
Pleocytosis 37.95 9.33 23 158450 537 50446114
Pulmonary mucormycosis 37.75 9.33 17 158456 209 50446442
Nephropathy toxic 37.75 9.33 80 158393 7949 50438702
Inappropriate schedule of product administration 37.75 9.33 108 158365 71723 50374928
Pedal pulse abnormal 37.72 9.33 15 158458 132 50446519
Oedema peripheral 37.15 9.33 316 158157 157645 50289006
Feeding intolerance 36.95 9.33 22 158451 497 50446154
Gastrointestinal disorder 36.92 9.33 161 158312 94295 50352356
Hypoglycaemia 36.63 9.33 70 158403 53511 50393140
Necrotising herpetic retinopathy 36.54 9.33 13 158460 81 50446570
Chronic graft versus host disease 36.52 9.33 45 158428 2822 50443829
Polyomavirus viraemia 36.46 9.33 21 158452 445 50446206
Epstein-Barr virus associated lymphoproliferative disorder 36.43 9.33 35 158438 1654 50444997
Lung abscess 36.37 9.33 34 158439 1552 50445099
Decreased appetite 36.02 9.33 429 158044 200494 50246157
Rebound effect 35.79 9.33 47 158426 3142 50443509
Staphylococcal infection 35.73 9.33 212 158261 35404 50411247
Hyponatraemia 35.70 9.33 167 158306 95972 50350679
Nephrotic syndrome 35.62 9.33 58 158415 4712 50441939
Contusion 35.42 9.33 206 158267 111977 50334674
Transplant failure 35.35 9.33 32 158441 1401 50445250
Cytomegalovirus enterocolitis 35.08 9.33 22 158451 547 50446104
Segmental diverticular colitis 35.03 9.33 14 158459 125 50446526
Stenotrophomonas infection 34.90 9.33 34 158439 1635 50445016
Cerebrovascular accident 34.85 9.33 165 158308 94515 50352136
Bacteraemia 34.85 9.33 112 158361 14321 50432330
Q fever 34.68 9.33 12 158461 68 50446583
Herpes virus infection 34.64 9.33 58 158415 4823 50441828
Pancytopenia 34.59 9.33 409 158064 83621 50363030
Pneumocystis jirovecii infection 34.50 9.33 30 158443 1245 50445406
Encephalitis 34.08 9.33 73 158400 7307 50439344
Injection site bruising 33.94 9.33 39 158434 36729 50409922
Food allergy 33.64 9.33 77 158396 8060 50438591
Therapy non-responder 33.60 9.33 274 158199 50748 50395903
C-reactive protein increased 33.57 9.33 337 158136 66137 50380514
Encephalitis cytomegalovirus 33.52 9.33 21 158452 521 50446130
Feeling hot 33.51 9.33 224 158249 38978 50407673
C-reactive protein abnormal 33.48 9.33 23 158450 27786 50418865
Post-traumatic stress disorder 33.06 9.33 53 158420 4250 50442401
Hip arthroplasty 33.01 9.33 28 158445 30401 50416250
Necrotising retinitis 33.01 9.33 17 158456 286 50446365
Thunderclap headache 32.79 9.33 14 158459 150 50446501
Cerebral aspergillosis 32.67 9.33 18 158455 349 50446302
Gastroenteritis rotavirus 32.44 9.33 13 158460 117 50446534
Rash 32.43 9.33 1084 157389 436387 50010264
Shock haemorrhagic 32.35 9.33 77 158396 8267 50438384
Quadriparesis 32.27 9.33 33 158440 1683 50444968
Hypersensitivity 32.16 9.33 477 157996 214684 50231967
Partial seizures 32.14 9.33 56 158417 4809 50441842
Calcium ionised decreased 31.95 9.33 16 158457 253 50446398
Respiratory rate increased 31.83 9.33 93 158380 11292 50435359
Nitrite urine present 31.73 9.33 25 158448 902 50445749
Diabetes mellitus 31.58 9.33 262 158211 48771 50397880
Hypertension 31.15 9.33 874 157599 210329 50236322
Diffuse large B-cell lymphoma 30.88 9.33 60 158413 5602 50441049
Immunosuppressant drug level decreased 30.82 9.33 24 158449 851 50445800
Central nervous system lymphoma 30.80 9.33 29 158444 1336 50445315
Incorrect dose administered 30.75 9.33 66 158407 48348 50398303
Laryngeal stenosis 30.58 9.33 23 158450 774 50445877
Viraemia 30.52 9.33 26 158447 1049 50445602
Malignant neoplasm progression 30.51 9.33 110 158363 68014 50378637
Parvovirus B19 infection 30.45 9.33 19 158454 468 50446183
Swollen joint count increased 30.42 9.33 5 158468 14868 50431783
Injection site swelling 29.95 9.33 53 158420 41720 50404931
Hyperglycaemia 29.91 9.33 206 158267 36199 50410452
Hypofibrinogenaemia 29.75 9.33 26 158447 1086 50445565
Intestinal perforation 29.68 9.33 86 158387 10393 50436258
Multiple sclerosis 29.59 9.33 135 158338 20358 50426293
Human bocavirus infection 29.57 9.33 17 158456 359 50446292
Injection site reaction 29.50 9.33 71 158402 49961 50396690
Sleep disorder 29.46 9.33 87 158386 57196 50389455
West Nile viral infection 29.44 9.33 17 158456 362 50446289
Intentional product misuse 29.44 9.33 64 158409 46670 50399981
Hyperammonaemia 29.43 9.33 53 158420 4671 50441980
Intentional self-injury 29.34 9.33 18 158455 23094 50423557
Proteus infection 29.33 9.33 23 158450 824 50445827
Pulmonary tuberculosis 29.29 9.33 50 158423 4223 50442428
Mobility decreased 29.02 9.33 140 158333 79808 50366843
Specific gravity urine decreased 29.00 9.33 21 158452 666 50445985
Band sensation 28.92 9.33 21 158452 669 50445982
Intra-abdominal pressure increased 28.91 9.33 14 158459 205 50446446
Epstein-Barr virus infection reactivation 28.91 9.33 19 158454 513 50446138
Malignant catatonia 28.57 9.33 12 158461 123 50446528
Rhodococcus infection 28.57 9.33 11 158462 88 50446563
Gastroenteritis norovirus 28.24 9.33 31 158442 1716 50444935
Escherichia urinary tract infection 28.19 9.33 84 158389 10311 50436340
Accidental overdose 28.04 9.33 13 158460 19520 50427131
Blood calcium decreased 27.89 9.33 15 158458 20691 50425960
Dermatomyositis 27.65 9.33 34 158439 2127 50444524
Blood thyroid stimulating hormone decreased 27.53 9.33 48 158425 4124 50442527
Smear cervix abnormal 27.12 9.33 38 158435 2703 50443948
Mean cell haemoglobin decreased 27.01 9.33 42 158431 3281 50443370
Device malfunction 26.98 9.33 7 158466 15114 50431537
Factor XIII deficiency 26.64 9.33 10 158463 74 50446577
Malaise 26.61 9.33 824 157649 334708 50111943
Substance-induced psychotic disorder 26.44 9.33 29 158444 1604 50445047
Cataract 26.44 9.33 245 158228 47055 50399596
Fibromyalgia 26.39 9.33 64 158409 44914 50401737
Choroiditis 26.26 9.33 11 158462 112 50446539
Leukoencephalopathy 26.05 9.33 45 158428 3838 50442813
Aspergillosis oral 26.01 9.33 9 158464 51 50446600
Cerebral artery stenosis 25.86 9.33 16 158457 388 50446263
B-lymphocyte count decreased 25.82 9.33 22 158451 888 50445763
Chronic graft versus host disease in liver 25.76 9.33 14 158459 264 50446387
Multiple-drug resistance 25.71 9.33 41 158432 3273 50443378
Diffuse alveolar damage 25.65 9.33 21 158452 801 50445850
Neuropsychiatric lupus 25.59 9.33 12 158461 163 50446488
Hepatic enzyme increased 25.51 9.33 291 158182 137089 50309562
Hepatic necrosis 25.50 9.33 53 158420 5195 50441456
Malacoplakia vesicae 25.44 9.33 9 158464 55 50446596
Cytomegalovirus enteritis 25.44 9.33 13 158460 215 50446436
Anti-thyroid antibody positive 25.43 9.33 16 158457 400 50446251
Red blood cell count increased 25.33 9.33 36 158437 2595 50444056
Graft versus host disease in liver 25.30 9.33 17 158456 477 50446174
Quadriplegia 25.17 9.33 29 158444 1694 50444957
Steroid dependence 25.15 9.33 15 158458 340 50446311
Pneumonia klebsiella 25.12 9.33 31 158442 1947 50444704
Renal tubular atrophy 25.10 9.33 18 158455 562 50446089
Cytomegalovirus gastrointestinal infection 25.03 9.33 14 158459 280 50446371
Clostridium difficile colitis 24.96 9.33 116 158357 17626 50429025
Injection site pruritus 24.91 9.33 56 158417 40355 50406296
Malacoplakia gastrointestinal 24.78 9.33 9 158464 60 50446591
Peritonitis 24.62 9.33 105 158368 15381 50431270
Chronic graft versus host disease in skin 24.61 9.33 19 158454 665 50445986
Pyomyositis 24.53 9.33 15 158458 356 50446295
Rubella antibody positive 24.41 9.33 9 158464 63 50446588
Device dislocation 24.40 9.33 19 158454 21527 50425124
Coeliac disease 24.33 9.33 71 158402 8614 50438037
Meningoencephalitis viral 24.25 9.33 14 158459 298 50446353
Multiple sclerosis relapse 24.25 9.33 223 158250 42741 50403910
Pulmonary haemorrhage 24.20 9.33 59 158414 6433 50440218
Lethargy 24.05 9.33 77 158396 49355 50397296
Urinary tract infection bacterial 23.82 9.33 45 158428 4114 50442537
Interleukin-2 receptor increased 23.82 9.33 9 158464 68 50446583
Focal segmental glomerulosclerosis 23.80 9.33 25 158448 1316 50445335
Pyelonephritis fungal 23.77 9.33 10 158463 103 50446548
Pathogen resistance 23.70 9.33 54 158419 5635 50441016
Faecal volume decreased 23.48 9.33 11 158462 149 50446502
Klebsiella test positive 23.38 9.33 21 158452 910 50445741
CSF protein increased 23.37 9.33 16 158457 463 50446188
Red blood cell sedimentation rate abnormal 23.27 9.33 11 158462 16332 50430319
Psoriasis 23.24 9.33 124 158349 68876 50377775
Intentional product use issue 23.21 9.33 354 158119 76564 50370087
Bacterial sepsis 23.11 9.33 41 158432 3571 50443080
Sense of oppression 23.11 9.33 21 158452 924 50445727
Product prescribing error 23.09 9.33 19 158454 20942 50425709
Psoriatic arthropathy 23.06 9.33 73 158400 46959 50399692
Muir-Torre syndrome 23.04 9.33 7 158466 24 50446627
Hepatitis B 23.03 9.33 40 158433 3426 50443225
Gastropleural fistula 23.02 9.33 8 158465 46 50446605
Tuberculosis gastrointestinal 22.98 9.33 14 158459 330 50446321
Kaposi's sarcoma 22.97 9.33 11 158462 157 50446494
Hypophagia 22.90 9.33 32 158441 27696 50418955
Osteomyelitis fungal 22.76 9.33 6 158467 10 50446641
Corynebacterium infection 22.76 9.33 15 158458 407 50446244
Glomerulosclerosis 22.61 9.33 14 158459 340 50446311
Pregnancy 22.61 9.33 36 158437 29541 50417110
Pyelonephritis 22.58 9.33 100 158373 14889 50431762
Rhabdomyolysis 22.53 9.33 56 158417 38971 50407680
Pulmonary nocardiosis 22.48 9.33 11 158462 165 50446486
Pneumatosis 22.47 9.33 15 158458 416 50446235
Disseminated varicella zoster vaccine virus infection 22.46 9.33 8 158465 50 50446601
Gastrointestinal mucormycosis 22.43 9.33 12 158461 219 50446432
Herpes simplex oesophagitis 22.42 9.33 10 158463 120 50446531
Urinary tract candidiasis 22.41 9.33 16 158457 496 50446155
Red blood cells urine 22.38 9.33 16 158457 497 50446154
Bacillus infection 22.24 9.33 16 158457 502 50446149
Complication associated with device 22.24 9.33 9 158464 14646 50432005
Gastrooesophageal reflux disease 22.21 9.33 144 158329 76284 50370367
IgA nephropathy 22.16 9.33 15 158458 426 50446225
Drug-induced liver injury 21.92 9.33 157 158316 27938 50418713
Ultrasound ovary abnormal 21.89 9.33 9 158464 87 50446564
Oral herpes 21.84 9.33 125 158348 20600 50426051
CSF measles antibody positive 21.57 9.33 8 158465 57 50446594
Temperature intolerance 21.48 9.33 62 158411 7477 50439174
Tuberculosis 21.46 9.33 75 158398 10008 50436643
Hairy cell leukaemia 21.44 9.33 6 158467 14 50446637
Haemolytic anaemia 21.44 9.33 71 158402 9221 50437430
Escherichia sepsis 21.40 9.33 44 158429 4280 50442371
Natural killer-cell leukaemia 21.37 9.33 9 158464 93 50446558
Biloma 21.34 9.33 8 158465 59 50446592
Chorioretinitis 21.32 9.33 15 158458 454 50446197
Haemolytic uraemic syndrome 21.26 9.33 31 158442 2288 50444363
Lip pruritus 21.15 9.33 18 158455 725 50445926
Birdshot chorioretinopathy 21.00 9.33 8 158465 62 50446589
Device difficult to use 20.96 9.33 3 158470 9883 50436768
Hepatic cyst infection 20.95 9.33 9 158464 98 50446553
Toxoplasmosis 20.95 9.33 24 158449 1393 50445258
Device issue 20.91 9.33 19 158454 19953 50426698
Unresponsive to stimuli 20.91 9.33 40 158433 30569 50416082
Central nervous system viral infection 20.87 9.33 9 158464 99 50446552
Memory impairment 20.85 9.33 154 158319 79206 50367445
Tachycardia 20.80 9.33 433 158040 99330 50347321
Large intestine perforation 20.74 9.33 61 158412 7433 50439218
Therapeutic product effect incomplete 20.65 9.33 185 158288 91330 50355321
Autoimmune hepatitis 20.62 9.33 61 158412 7458 50439193
Hypertriglyceridaemia 20.57 9.33 50 158423 5441 50441210
Meningoencephalitis bacterial 20.57 9.33 8 158465 66 50446585
Bronchostenosis 20.55 9.33 14 158459 402 50446249
Blood potassium increased 20.50 9.33 13 158460 16385 50430266
Trichodysplasia spinulosa 20.41 9.33 15 158458 487 50446164
Full blood count decreased 20.30 9.33 24 158449 22322 50424329
Aplasia 20.30 9.33 40 158433 3773 50442878
Cryptococcosis 20.29 9.33 19 158454 869 50445782
Acute respiratory failure 20.28 9.33 157 158316 28625 50418026
Rash erythematous 20.23 9.33 182 158291 34670 50411981
Cerebellar stroke 20.21 9.33 11 158462 208 50446443
Chest discomfort 20.17 9.33 405 158068 92317 50354334
Obstructive airways disorder 20.13 9.33 12 158461 15640 50431011
Cerebral venous thrombosis 20.11 9.33 27 158446 1844 50444807
Joint tuberculosis 20.03 9.33 9 158464 110 50446541
Graft loss 20.01 9.33 13 158460 344 50446307
Bone pain 20.01 9.33 78 158395 47151 50399500
Liver abscess 20.01 9.33 32 158441 2561 50444090
Staphylococcal bacteraemia 19.99 9.33 46 158427 4831 50441820
Thyroxine free increased 19.98 9.33 18 158455 783 50445868
Cytokine release syndrome 19.94 9.33 66 158407 8568 50438083
Treatment failure 19.90 9.33 307 158166 137330 50309321
Urticaria 19.88 9.33 539 157934 129022 50317629
Perinephric abscess 19.81 9.33 10 158463 161 50446490
Aeromonas infection 19.77 9.33 8 158465 74 50446577
Steroid withdrawal syndrome 19.76 9.33 15 158458 512 50446139
Pain in extremity 19.73 9.33 678 157795 272187 50174464
Candida sepsis 19.65 9.33 22 158451 1245 50445406
Interleukin level increased 19.62 9.33 12 158461 285 50446366
Syncope 19.58 9.33 217 158256 102785 50343866
Unevaluable event 19.57 9.33 76 158397 45990 50400661
Blood glucose decreased 19.46 9.33 17 158456 18194 50428457
Biliary anastomosis complication 19.44 9.33 6 158467 22 50446629
Hepatitis acute 19.42 9.33 62 158411 7899 50438752
Product storage error 19.39 9.33 7 158466 12217 50434434
Blood creatinine decreased 19.38 9.33 46 158427 4930 50441721
Low birth weight baby 19.37 9.33 51 158422 5830 50440821
Pain in jaw 19.30 9.33 59 158414 38369 50408282
Hallucination 19.17 9.33 78 158395 46579 50400072
Tri-iodothyronine free decreased 19.15 9.33 12 158461 298 50446353
Secondary immunodeficiency 19.07 9.33 21 158452 1167 50445484
Loss of consciousness 18.99 9.33 222 158251 104131 50342520
Growth retardation 18.96 9.33 20 158453 1058 50445593
Pneumonia lipoid 18.88 9.33 9 158464 127 50446524
Anal erythema 18.86 9.33 10 158463 179 50446472
Blood brain barrier defect 18.80 9.33 8 158465 85 50446566
Joint swelling 18.78 9.33 605 157868 244681 50201970
Leukocytosis 18.68 9.33 128 158345 22451 50424200
Lichen sclerosus 18.63 9.33 19 158454 966 50445685
Epstein-Barr viraemia 18.61 9.33 18 158455 858 50445793
Fungaemia 18.59 9.33 27 158446 1985 50444666
Macular degeneration 18.55 9.33 11 158462 14377 50432274
Aphthous ulcer 18.54 9.33 74 158399 10523 50436128
Allergy test positive 18.52 9.33 13 158460 392 50446259
Coronary artery disease 18.48 9.33 41 158432 29685 50416966
Myelitis 18.41 9.33 21 158452 1213 50445438
Mean cell volume decreased 18.34 9.33 31 158442 2598 50444053
Listeria encephalitis 18.30 9.33 11 158462 253 50446398
Sebaceous carcinoma 18.30 9.33 6 158467 28 50446623
Swollen tongue 18.20 9.33 39 158434 28591 50418060
Hepatitis toxic 18.07 9.33 32 158441 2784 50443867
Poor venous access 17.92 9.33 72 158401 10268 50436383
Serratia infection 17.88 9.33 17 158456 793 50445858
Glomerulonephritis chronic 17.88 9.33 9 158464 144 50446507
Gamma-glutamyltransferase increased 17.86 9.33 156 158317 29467 50417184
Serum sickness 17.85 9.33 30 158443 2502 50444149
Renal artery stenosis 17.78 9.33 24 158449 1648 50445003
Tendon rupture 17.76 9.33 56 158417 7088 50439563
Monocyte percentage increased 17.75 9.33 19 158454 1022 50445629
Pulmonary hypertension 17.73 9.33 50 158423 33367 50413284
Eye infection toxoplasmal 17.70 9.33 11 158462 269 50446382
Impaired healing 17.58 9.33 137 158336 69649 50377002
Graft versus host disease in lung 17.57 9.33 12 158461 346 50446305
Allergy to plants 17.57 9.33 15 158458 607 50446044
Globulins decreased 17.44 9.33 10 158463 210 50446441
Hepatocellular injury 17.43 9.33 140 158333 25807 50420844
Band neutrophil percentage increased 17.40 9.33 10 158463 211 50446440
Enterococcus test positive 17.26 9.33 19 158454 1055 50445596
Eosinopenia 17.20 9.33 6 158467 35 50446616
Mycobacterial infection 17.11 9.33 23 158450 1573 50445078
Fusarium infection 17.06 9.33 14 158459 536 50446115
Penicillium infection 17.04 9.33 8 158465 109 50446542
Pneumonia cryptococcal 17.02 9.33 15 158458 634 50446017
Pneumonia bacterial 17.00 9.33 56 158417 7253 50439398
Drug level decreased 16.97 9.33 52 158421 6481 50440170
Bone marrow failure 16.93 9.33 146 158327 27478 50419173
Therapeutic response decreased 16.90 9.33 224 158249 47007 50399644
Toxic neuropathy 16.87 9.33 12 158461 370 50446281
Haemoglobin urine 16.84 9.33 8 158465 112 50446539
Drug tolerance decreased 16.81 9.33 4 158469 9156 50437495
Atrial fibrillation 16.80 9.33 221 158252 101524 50345127
Torsade de pointes 16.80 9.33 8 158465 11827 50434824
Joint effusion 16.77 9.33 83 158390 12938 50433713
Urine oxalate increased 16.75 9.33 10 158463 227 50446424
Poisoning 16.75 9.33 9 158464 12420 50434231
Creatinine urine decreased 16.74 9.33 9 158464 166 50446485
Chromoblastomycosis 16.72 9.33 5 158468 16 50446635
Butterfly rash 16.72 9.33 20 158453 1216 50445435
White blood cell count increased 16.67 9.33 204 158269 42036 50404615
Foetal growth restriction 16.52 9.33 52 158421 6575 50440076
Orbital apex syndrome 16.52 9.33 6 158467 40 50446611
Full blood count abnormal 16.47 9.33 30 158443 23358 50423293
Cytomegalovirus hepatitis 16.45 9.33 11 158462 306 50446345
Transient hypogammaglobulinaemia of infancy 16.39 9.33 6 158467 41 50446610
Nasal septum disorder 16.35 9.33 8 158465 120 50446531
Abscess 16.32 9.33 88 158385 14184 50432467
Haemorrhagic varicella syndrome 16.32 9.33 4 158469 4 50446647
Visceral leishmaniasis 16.31 9.33 13 158460 477 50446174
Central obesity 16.29 9.33 18 158455 1004 50445647
Osteonecrosis of jaw 16.29 9.33 50 158423 32476 50414175
Sputum discoloured 16.23 9.33 11 158462 13384 50433267
Optic neuritis 16.21 9.33 53 158420 6837 50439814
Renal tubular necrosis 16.21 9.33 69 158404 10099 50436552
Thyroid stimulating immunoglobulin increased 16.15 9.33 7 158466 78 50446573
Feeling abnormal 16.14 9.33 286 158187 125206 50321445
Diabetic macroangiopathy 16.12 9.33 8 158465 124 50446527
Hypoproteinaemia 16.10 9.33 24 158449 1807 50444844
Hepatic infarction 16.08 9.33 14 158459 582 50446069
Cough 16.03 9.33 916 157557 240348 50206303
Fungal skin infection 16.02 9.33 36 158437 3723 50442928
Injection site warmth 15.99 9.33 12 158461 13854 50432797
Leukocyturia 15.99 9.33 18 158455 1025 50445626
Renal impairment 15.96 9.33 329 158144 75332 50371319
Meningitis chemical 15.95 9.33 8 158465 127 50446524
Foetal exposure during delivery 15.92 9.33 6 158467 45 50446606
Organic brain syndrome 15.91 9.33 9 158464 184 50446467
Pneumonia acinetobacter 15.86 9.33 5 158468 20 50446631
Hepatic cirrhosis 15.84 9.33 19 158454 17558 50429093
Systemic inflammatory response syndrome 15.83 9.33 43 158430 5006 50441645
Ulcer 15.83 9.33 113 158360 20087 50426564
Transient ischaemic attack 15.79 9.33 50 158423 32160 50414491
Therapy partial responder 15.78 9.33 51 158422 6540 50440111
Premenstrual syndrome 15.76 9.33 14 158459 598 50446053
Autoimmune thyroiditis 15.75 9.33 33 158440 3252 50443399
Neuromyelitis optica spectrum disorder 15.74 9.33 16 158457 810 50445841
Bursitis 15.74 9.33 121 158352 22014 50424637
Osteoporosis 15.71 9.33 212 158261 44667 50401984
Erythrosis 15.69 9.33 6 158467 47 50446604
Meningomyelitis herpes 15.67 9.33 5 158468 21 50446630
Parainfluenzae virus infection 15.66 9.33 24 158449 1851 50444800
Blood immunoglobulin M decreased 15.63 9.33 15 158458 708 50445943
Toxic epidermal necrolysis 15.62 9.33 116 158357 20876 50425775
Dyspnoea 15.60 9.33 1490 156983 546118 49900533
Tubulointerstitial nephritis 15.55 9.33 91 158382 15120 50431531
Monoparesis 15.54 9.33 21 158452 1443 50445208
Band neutrophil count increased 15.44 9.33 11 158462 340 50446311
Excessive skin 15.41 9.33 8 158465 137 50446514
Injection site haemorrhage 15.37 9.33 27 158446 21319 50425332
Parathyroid hyperplasia 15.35 9.33 8 158465 138 50446513
Pyometra 15.34 9.33 7 158466 89 50446562
Thrombosis 15.32 9.33 107 158366 55726 50390925
Moraxella infection 15.30 9.33 11 158462 345 50446306
Capillaritis 15.27 9.33 7 158466 90 50446561
Sinusitis 15.21 9.33 412 158061 170146 50276505
Underdose 15.20 9.33 25 158448 20253 50426398
Type I hypersensitivity 15.17 9.33 27 158446 2358 50444293
Seroconversion test positive 15.13 9.33 5 158468 24 50446627
Infection 15.11 9.33 419 158054 172535 50274116
Hyperpyrexia 15.06 9.33 31 158442 3018 50443633
Myelopathy 15.03 9.33 28 158445 2533 50444118
Delayed engraftment 15.00 9.33 7 158466 94 50446557
Cestode infection 14.99 9.33 10 158463 277 50446374
Incorrect route of product administration 14.96 9.33 22 158451 18644 50428007
Nosocomial infection 14.91 9.33 21 158452 1501 50445150
Pseudomonal sepsis 14.90 9.33 25 158448 2082 50444569
General physical health deterioration 14.89 9.33 336 158137 142098 50304553
Ovarian fibroma 14.87 9.33 7 158466 96 50446555
Enteritis 14.86 9.33 52 158421 6943 50439708
Complications of transplanted liver 14.86 9.33 11 158462 361 50446290
Atypical haemolytic uraemic syndrome 14.86 9.33 13 158460 544 50446107
Scleroderma renal crisis 14.84 9.33 10 158463 282 50446369
Pseudomonal bacteraemia 14.82 9.33 19 158454 1240 50445411
Polyglandular disorder 14.81 9.33 5 158468 26 50446625
Infected varicose vein 14.81 9.33 5 158468 26 50446625
Cutaneous lupus erythematosus 14.80 9.33 27 158446 2404 50444247
Inflammatory marker increased 14.78 9.33 45 158428 5589 50441062
Blood beta-D-glucan increased 14.74 9.33 9 158464 213 50446438
Skin fissures 14.74 9.33 60 158413 8608 50438043
Chronic graft versus host disease in eye 14.74 9.33 7 158466 98 50446553
Mental status changes 14.67 9.33 61 158412 36211 50410440
Ureteral disorder 14.62 9.33 10 158463 289 50446362
Germ cell cancer 14.60 9.33 6 158467 58 50446593
Asthenia 14.55 9.33 834 157639 318208 50128443
Adenoviral haemorrhagic cystitis 14.53 9.33 8 158465 155 50446496
Hepatosplenomegaly 14.48 9.33 26 158447 2286 50444365
Lymphocele 14.48 9.33 15 158458 777 50445874
Coloboma 14.42 9.33 6 158467 60 50446591
Plasma cell myeloma 14.40 9.33 50 158423 31272 50415379
Oral pain 14.38 9.33 36 158437 24997 50421654
Bronchiolitis obliterans syndrome 14.37 9.33 7 158466 104 50446547
Nail bed inflammation 14.35 9.33 11 158462 381 50446270
Pneumonia pseudomonal 14.30 9.33 24 158449 1999 50444652
Diffuse large B-cell lymphoma refractory 14.27 9.33 17 158456 1029 50445622
Papilloma viral infection 14.26 9.33 19 158454 1288 50445363
Product dispensing error 14.26 9.33 5 158468 8886 50437765
Herpes simplex encephalitis 14.24 9.33 10 158463 302 50446349
Type IIb hyperlipidaemia 14.21 9.33 5 158468 30 50446621
Hypokalaemia 14.21 9.33 192 158281 87800 50358851
Malacoplakia 14.19 9.33 7 158466 107 50446544
Monocyte count decreased 14.18 9.33 23 158450 1863 50444788
Menstruation irregular 14.14 9.33 47 158426 6115 50440536
Coagulation factor VIII level increased 14.10 9.33 4 158469 10 50446641
Hepatic artery aneurysm 14.10 9.33 4 158469 10 50446641
Blood loss anaemia 14.08 9.33 4 158469 8135 50438516
Transaminases increased 14.01 9.33 141 158332 27683 50418968
Haemodynamic instability 14.01 9.33 56 158417 7968 50438683
Sleep disorder due to a general medical condition 13.96 9.33 3 158470 7368 50439283
Microsporidia infection 13.96 9.33 9 158464 235 50446416
Chronic graft versus host disease oral 13.96 9.33 7 158466 111 50446540
Spinal cord paralysis 13.94 9.33 5 158468 32 50446619
Refractory anaemia with an excess of blasts 13.94 9.33 11 158462 398 50446253
Central nervous system vasculitis 13.92 9.33 15 158458 813 50445838
Microangiopathic haemolytic anaemia 13.88 9.33 12 158461 494 50446157
Wound infection bacterial 13.88 9.33 12 158461 494 50446157
Occult blood 13.87 9.33 18 158455 1189 50445462
Haemostasis 13.86 9.33 9 158464 238 50446413
Dyskinesia 13.83 9.33 43 158430 27818 50418833
Suicidal ideation 13.83 9.33 109 158364 55276 50391375
Spinal cord infarction 13.79 9.33 9 158464 240 50446411
Coordination abnormal 13.79 9.33 72 158401 11462 50435189
Tardive dyskinesia 13.71 9.33 3 158470 7276 50439375
Body temperature decreased 13.60 9.33 93 158380 16302 50430349
Chest pain 13.59 9.33 436 158037 176446 50270205
Vaginal haemorrhage 13.57 9.33 36 158437 24515 50422136
Laryngeal mass 13.56 9.33 5 158468 35 50446616
Infective pulmonary exacerbation of cystic fibrosis 13.48 9.33 4 158469 7905 50438746
Influenza like illness 13.47 9.33 115 158358 57344 50389307
Candida test positive 13.40 9.33 15 158458 849 50445802
Neurosarcoidosis 13.38 9.33 8 158465 182 50446469
Evans syndrome 13.35 9.33 8 158465 183 50446468
Blood immunoglobulin G decreased 13.31 9.33 23 158450 1962 50444689
Asymptomatic bacteriuria 13.28 9.33 9 158464 256 50446395
Lower limb fracture 13.27 9.33 15 158458 14231 50432420
Breast cancer metastatic 13.25 9.33 8 158465 10356 50436295
Hepatic failure 13.21 9.33 157 158316 32126 50414525
Mucocutaneous leishmaniasis 13.18 9.33 10 158463 341 50446310
Urine leukocyte esterase 13.17 9.33 7 158466 126 50446525
Muscle hypertrophy 13.16 9.33 6 158467 76 50446575
Oropharyngeal plaque 13.16 9.33 9 158464 260 50446391
Bacterial vulvovaginitis 13.14 9.33 13 158460 637 50446014
Microangiopathy 13.13 9.33 15 158458 868 50445783
Product complaint 13.13 9.33 10 158463 11456 50435195
Adjusted calcium decreased 13.12 9.33 7 158466 127 50446524
Hypertrichosis 13.11 9.33 16 158457 993 50445658
Intestinal infarction 13.08 9.33 16 158457 996 50445655
Varicella 13.02 9.33 21 158452 1693 50444958
Urinary casts 12.92 9.33 13 158460 650 50446001
Angiocentric lymphoma 12.91 9.33 12 158461 544 50446107
Dystonia 12.90 9.33 11 158462 11915 50434736
Product substitution issue 12.87 9.33 15 158458 14042 50432609
Hypotension 12.87 9.33 879 157594 234590 50212061
Low cardiac output syndrome 12.86 9.33 9 158464 270 50446381
Monocyte percentage decreased 12.86 9.33 8 158465 196 50446455
Nodal osteoarthritis 12.78 9.33 14 158459 773 50445878
Intestine transplant rejection 12.78 9.33 5 158468 42 50446609
Hepatic haemorrhage 12.74 9.33 11 158462 452 50446199
Paraparesis 12.66 9.33 23 158450 2041 50444610
Product contamination 12.65 9.33 12 158461 558 50446093
Specific gravity urine increased 12.65 9.33 8 158465 202 50446449
Mean cell haemoglobin concentration increased 12.64 9.33 11 158462 457 50446194
Epstein-Barr virus associated lymphoma 12.62 9.33 11 158462 458 50446193
Mucous stools 12.60 9.33 28 158445 2874 50443777
Cryptococcal fungaemia 12.57 9.33 5 158468 44 50446607
Pneumocephalus 12.56 9.33 7 158466 139 50446512
Acarodermatitis 12.53 9.33 15 158458 913 50445738
Myelocyte percentage increased 12.51 9.33 8 158465 206 50446445
Ureteric stenosis 12.49 9.33 12 158461 567 50446084
Nose deformity 12.42 9.33 7 158466 142 50446509
Enterocolitis viral 12.41 9.33 8 158465 209 50446442
Adult T-cell lymphoma/leukaemia 12.41 9.33 8 158465 209 50446442
Vascular rupture 12.34 9.33 18 158455 1329 50445322
Abnormal dreams 12.33 9.33 7 158466 9370 50437281
Blood lactate dehydrogenase increased 12.31 9.33 104 158369 19458 50427193
Haematemesis 12.25 9.33 45 158428 27680 50418971
Drug withdrawal syndrome 12.24 9.33 39 158434 25042 50421609
Erectile dysfunction 12.24 9.33 3 158470 3 50446648
Meningitis listeria 12.20 9.33 11 158462 479 50446172
Renal vein thrombosis 12.20 9.33 9 158464 294 50446357
Skin striae 12.18 9.33 16 158457 1070 50445581
Lower respiratory tract infection bacterial 12.17 9.33 9 158464 295 50446356
Weight increased 12.17 9.33 760 157713 201131 50245520
Abdominal pain upper 12.16 9.33 393 158080 158916 50287735
Carcinoma in situ 12.15 9.33 6 158467 92 50446559
Schizophrenia 12.14 9.33 4 158469 7393 50439258
Bacterial infection 12.14 9.33 90 158383 16191 50430460
Subcutaneous haematoma 12.11 9.33 19 158454 1496 50445155
Injection site mass 12.07 9.33 19 158454 15661 50430990
Aspergilloma 12.04 9.33 7 158466 151 50446500
Escherichia pyelonephritis 12.03 9.33 10 158463 390 50446261
Magnesium deficiency 12.01 9.33 11 158462 489 50446162
Neonatal pneumonia 11.97 9.33 4 158469 20 50446631
Fungal infection 11.95 9.33 145 158328 29820 50416831
Ureteral necrosis 11.93 9.33 5 158468 51 50446600
Acute myeloid leukaemia recurrent 11.91 9.33 18 158455 1372 50445279
Nightmare 11.90 9.33 20 158453 16066 50430585
Blood cholesterol increased 11.85 9.33 113 158360 55102 50391549
Mean cell haemoglobin concentration decreased 11.76 9.33 27 158446 2832 50443819
Dementia 11.73 9.33 20 158453 15977 50430674
Hepatitis C 11.73 9.33 38 158435 4879 50441772
Complications of transplant surgery 11.72 9.33 7 158466 159 50446492
Paralysis 11.72 9.33 56 158417 8608 50438043
Gait disturbance 11.70 9.33 369 158104 149636 50297015
Therapy cessation 11.64 9.33 42 158431 25969 50420682
Paraesthesia ear 11.61 9.33 7 158466 162 50446489
Poikiloderma 11.61 9.33 7 158466 162 50446489
Right ventricular failure 11.54 9.33 20 158453 15873 50430778
Immunosuppression 11.53 9.33 50 158423 7376 50439275
Meningitis cryptococcal 11.52 9.33 16 158457 1129 50445522
Enterobacter pneumonia 11.51 9.33 4 158469 23 50446628
Histoplasmosis disseminated 11.51 9.33 17 158456 1269 50445382
Blindness 11.50 9.33 93 158380 17176 50429475
Metastases to liver 11.48 9.33 29 158444 20075 50426576
Cortisol decreased 11.47 9.33 15 158458 999 50445652
Acid base balance abnormal 11.46 9.33 8 158465 239 50446412
Mycoplasma test positive 11.44 9.33 5 158468 57 50446594
Kidney fibrosis 11.43 9.33 19 158454 1570 50445081
Injection site induration 11.43 9.33 6 158467 8391 50438260
Vasculitis necrotising 11.43 9.33 11 158462 521 50446130
Blood parathyroid hormone decreased 11.41 9.33 4 158469 7110 50439541
Treatment noncompliance 11.41 9.33 52 158421 30098 50416553
Pterygium 11.38 9.33 7 158466 168 50446483
Aplasia pure red cell 11.37 9.33 34 158439 4181 50442470
Engraftment syndrome 11.37 9.33 9 158464 327 50446324
Passenger lymphocyte syndrome 11.36 9.33 5 158468 58 50446593
Coronavirus infection 11.32 9.33 27 158446 2902 50443749
Ecthyma 11.32 9.33 8 158465 244 50446407
Inflammatory pain 11.29 9.33 13 158460 759 50445892
Cryptococcal cutaneous infection 11.28 9.33 5 158468 59 50446592
Cardio-respiratory arrest 11.27 9.33 111 158362 53781 50392870
Cystitis viral 11.24 9.33 6 158467 109 50446542
Alopecia scarring 11.24 9.33 6 158467 109 50446542
Post procedural bile leak 11.24 9.33 6 158467 109 50446542
Glomerulonephritis membranous 11.24 9.33 11 158462 532 50446119
Calcification of muscle 11.23 9.33 4 158469 25 50446626
Infectious pleural effusion 11.21 9.33 16 158457 1158 50445493
Epilepsy 11.20 9.33 110 158363 21457 50425194
B-lymphocyte count increased 11.19 9.33 6 158467 110 50446541
Throat tightness 11.16 9.33 107 158366 20740 50425911
Exostosis 11.15 9.33 12 158461 11641 50435010
Extremity necrosis 11.14 9.33 18 158455 1453 50445198
Moyamoya disease 11.14 9.33 5 158468 61 50446590
Normal newborn 11.13 9.33 46 158427 6645 50440006
Neurological decompensation 11.12 9.33 23 158450 2247 50444404
Neuralgia 11.11 9.33 111 158362 21752 50424899
Sopor 11.10 9.33 29 158444 19850 50426801
Acute motor axonal neuropathy 11.10 9.33 4 158469 26 50446625
Salmonella test positive 11.10 9.33 4 158469 26 50446625
Parkinsonism 11.08 9.33 7 158466 8840 50437811
Hepatic artery thrombosis 11.07 9.33 5 158468 62 50446589
Osseous cryptococcosis 11.03 9.33 3 158470 6 50446645
Flatulence 11.03 9.33 51 158422 29407 50417244
Impaired work ability 11.01 9.33 16 158457 13624 50433027
Transplant dysfunction 10.99 9.33 36 158437 4648 50442003
Ophthalmoplegia 10.98 9.33 17 158456 1323 50445328
Pneumonia legionella 10.94 9.33 17 158456 1327 50445324
Necrosis ischaemic 10.92 9.33 13 158460 786 50445865
Thyroid stimulating immunoglobulin 10.92 9.33 5 158468 64 50446587
Disseminated cytomegaloviral infection 10.92 9.33 7 158466 181 50446470
Locked-in syndrome 10.91 9.33 9 158464 347 50446304
Waxy flexibility 10.91 9.33 6 158467 116 50446535
Encephalitis brain stem 10.86 9.33 6 158467 117 50446534
T-lymphocyte count decreased 10.80 9.33 8 158465 263 50446388
Pharyngeal disorder 10.79 9.33 19 158454 1645 50445006
Histiocytic sarcoma 10.79 9.33 5 158468 66 50446585
Cryptococcal meningoencephalitis 10.79 9.33 5 158468 66 50446585
Bile duct stenosis 10.77 9.33 15 158458 1061 50445590
Cells in urine 10.75 9.33 7 158466 186 50446465
Encephalitis Japanese B 10.73 9.33 4 158469 29 50446622
Cancer in remission 10.73 9.33 4 158469 29 50446622
Otitis media 10.73 9.33 34 158439 4315 50442336
CSF oligoclonal band present 10.73 9.33 6 158467 120 50446531
Human herpes virus 8 test positive 10.72 9.33 3 158470 7 50446644
Thrombotic thrombocytopenic purpura 10.72 9.33 30 158443 3555 50443096
Eosinophilic myocarditis 10.72 9.33 9 158464 356 50446295
Pneumothorax 10.70 9.33 78 158395 13956 50432695
Bradyphrenia 10.69 9.33 3 158470 6149 50440502
Mycobacterium kansasii infection 10.64 9.33 6 158467 122 50446529
Respiratory arrest 10.63 9.33 53 158420 29956 50416695
Drug effective for unapproved indication 10.60 9.33 21 158452 1988 50444663
Hemivertebra 10.59 9.33 6 158467 123 50446528
Eosinophil percentage increased 10.57 9.33 14 158459 944 50445707
Cytokine storm 10.56 9.33 8 158465 272 50446379
Haematocrit decreased 10.56 9.33 161 158312 34815 50411836
Morganella infection 10.55 9.33 11 158462 574 50446077
Vesicoureteric reflux 10.52 9.33 7 158466 193 50446458
Retinal depigmentation 10.51 9.33 8 158465 274 50446377
Erythema migrans 10.50 9.33 4 158469 31 50446620
Thrombocytosis 10.49 9.33 37 158436 4959 50441692
Atypical mycobacterial infection 10.48 9.33 13 158460 821 50445830
Eosinophil count increased 10.48 9.33 55 158418 8775 50437876
Ocular procedural complication 10.40 9.33 9 158464 371 50446280
Psychiatric decompensation 10.37 9.33 16 158457 1242 50445409
Haemoperitoneum 10.37 9.33 24 158449 2531 50444120
Skin infection 10.36 9.33 70 158403 12221 50434430
Pulmonary arterial hypertension 10.34 9.33 31 158442 20288 50426363
Normochromic anaemia 10.34 9.33 8 158465 281 50446370
Palmar erythema 10.34 9.33 18 158455 1545 50445106
Creatinine urine increased 10.34 9.33 7 158466 199 50446452
Acute disseminated encephalomyelitis 10.34 9.33 7 158466 199 50446452
Persecutory delusion 10.33 9.33 23 158450 2364 50444287
Peripheral sensorimotor neuropathy 10.33 9.33 16 158457 1246 50445405
Hallucination, auditory 10.32 9.33 11 158462 10717 50435934
Hyperferritinaemia 10.30 9.33 6 158467 130 50446521
Heliotrope rash 10.30 9.33 6 158467 130 50446521
Premature baby 10.25 9.33 95 158378 18242 50428409
Blood thyroid stimulating hormone increased 10.22 9.33 42 158431 6050 50440601
Human polyomavirus infection 10.22 9.33 8 158465 286 50446365
Crystalluria 10.22 9.33 9 158464 380 50446271
Laryngitis 10.21 9.33 64 158409 10892 50435759
Graft complication 10.21 9.33 7 158466 203 50446448
Tri-iodothyronine free increased 10.18 9.33 7 158466 204 50446447
Seizure 10.18 9.33 286 158187 117588 50329063
Visual tracking test abnormal 10.18 9.33 3 158470 9 50446642
Myocardiac abscess 10.18 9.33 3 158470 9 50446642
Interstitial lung disease 10.18 9.33 228 158245 52948 50393703
Brain oedema 10.16 9.33 70 158403 12300 50434351
Bone erosion 10.15 9.33 13 158460 11674 50434977
Reticulocytosis 10.14 9.33 6 158467 134 50446517
Influenza 10.13 9.33 359 158114 89179 50357472
Endometrial ablation 10.12 9.33 13 158460 850 50445801
Encephalopathy 10.11 9.33 155 158318 33556 50413095
Beta 2 microglobulin increased 10.10 9.33 6 158467 135 50446516
Lymphocyte count increased 10.09 9.33 26 158447 2933 50443718
Achromobacter infection 10.08 9.33 4 158469 35 50446616
Bilirubin conjugated increased 10.04 9.33 23 158450 2409 50444242
Endocarditis 10.03 9.33 37 158436 5070 50441581
Angina pectoris 10.01 9.33 45 158428 26143 50420508
Oesophageal adenocarcinoma recurrent 9.98 9.33 4 158469 36 50446615
Incision site pain 9.98 9.33 14 158459 997 50445654
Genital herpes 9.97 9.33 18 158455 1589 50445062
Head injury 9.96 9.33 40 158433 23980 50422671
Coma 9.96 9.33 122 158351 56757 50389894
Pneumonia fungal 9.96 9.33 33 158440 4287 50442364
Fear 9.95 9.33 19 158454 14530 50432121
Nitrite urine 9.94 9.33 3 158470 10 50446641
Varicose ulceration 9.91 9.33 10 158463 502 50446149
Blindness cortical 9.89 9.33 9 158464 397 50446254
Plasma cells decreased 9.88 9.33 4 158469 37 50446614
Zinc deficiency 9.88 9.33 4 158469 37 50446614
Fracture 9.83 9.33 24 158449 16809 50429842
Skin irritation 9.83 9.33 6 158467 7721 50438930
Central nervous system lupus 9.82 9.33 8 158465 303 50446348
Immune-mediated arthritis 9.79 9.33 4 158469 38 50446613
Labelled drug-drug interaction medication error 9.79 9.33 11 158462 10466 50436185
Surgery 9.77 9.33 55 158418 30150 50416501
Body temperature increased 9.74 9.33 145 158328 31196 50415455
Sensory loss 9.74 9.33 49 158424 7689 50438962
Hepatic artery stenosis 9.72 9.33 3 158470 11 50446640
Conjunctivitis 9.72 9.33 85 158388 16060 50430591
CSF test abnormal 9.71 9.33 8 158465 308 50446343
Perineal ulceration 9.70 9.33 4 158469 39 50446612
Intestinal obstruction 9.69 9.33 46 158427 26337 50420314
Herpes simplex viraemia 9.68 9.33 6 158467 146 50446505
Lung transplant rejection 9.68 9.33 12 158461 757 50445894
Body temperature fluctuation 9.67 9.33 20 158453 1953 50444698
Procalcitonin increased 9.67 9.33 12 158461 758 50445893
Akathisia 9.65 9.33 7 158466 8222 50438429
Oedema 9.65 9.33 158 158315 70023 50376628
Serum ferritin increased 9.64 9.33 37 158436 5165 50441486
Oral candidiasis 9.64 9.33 88 158385 16827 50429824
CD4 lymphocytes decreased 9.62 9.33 16 158457 1323 50445328
Irritability 9.62 9.33 51 158422 28375 50418276
Paraspinal abscess 9.61 9.33 4 158469 40 50446611
Salivary gland mass 9.61 9.33 5 158468 86 50446565
Tuberous sclerosis complex 9.61 9.33 5 158468 86 50446565
Unmasking of previously unidentified disease 9.57 9.33 12 158461 766 50445885
Endometrial disorder 9.54 9.33 11 158462 643 50446008
Lymphoproliferative disorder 9.53 9.33 25 158448 2852 50443799
Parvimonas micra infection 9.52 9.33 3 158470 12 50446639
Cytomegalovirus duodenitis 9.52 9.33 3 158470 12 50446639
Lung disorder 9.51 9.33 195 158278 44604 50402047
B precursor type acute leukaemia 9.50 9.33 6 158467 151 50446500
Stem cell transplant 9.49 9.33 18 158455 1650 50445001
Impaired gastric emptying 9.48 9.33 8 158465 8710 50437941
Paradoxical drug reaction 9.45 9.33 29 158444 3618 50443033
Arterial rupture 9.43 9.33 8 158465 321 50446330
Urobilinogen urine increased 9.42 9.33 7 158466 231 50446420
Aspergillus test positive 9.39 9.33 8 158465 323 50446328
Pyuria 9.38 9.33 18 158455 1665 50444986
Type 2 diabetes mellitus 9.37 9.33 66 158407 34309 50412342
Diffuse large B-cell lymphoma stage III 9.36 9.33 4 158469 43 50446608
Infestation 9.36 9.33 4 158469 43 50446608
Obliterative bronchiolitis 9.34 9.33 19 158454 1834 50444817

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cytomegalovirus infection 804.68 9.99 660 102973 22555 29448339
Off label use 765.14 9.99 2547 101086 298253 29172641
Product use in unapproved indication 512.95 9.99 1014 102619 85861 29385033
Drug ineffective for unapproved indication 349.89 9.99 333 103300 13881 29457013
Death 311.54 9.99 449 103184 341635 29129259
Pneumocystis jirovecii pneumonia 296.68 9.99 329 103304 16450 29454444
Aspergillus infection 295.48 9.99 266 103367 10315 29460579
Kidney transplant rejection 291.60 9.99 222 103411 6783 29464111
Mucormycosis 284.66 9.99 194 103439 4964 29465930
Transplant rejection 282.04 9.99 244 103389 8968 29461926
Multiple organ dysfunction syndrome 270.63 9.99 648 102985 62468 29408426
Bronchopulmonary aspergillosis 269.79 9.99 271 103362 12073 29458821
Graft versus host disease 258.96 9.99 237 103396 9391 29461503
Posterior reversible encephalopathy syndrome 251.32 9.99 226 103407 8750 29462144
Drug ineffective 246.43 9.99 2136 101497 361034 29109860
Completed suicide 238.70 9.99 21 103612 90225 29380669
Post transplant lymphoproliferative disorder 230.66 9.99 175 103458 5318 29465576
Respiratory failure 207.31 9.99 779 102854 96352 29374542
Strongyloidiasis 206.24 9.99 118 103515 2194 29468700
Drug abuse 199.76 9.99 23 103610 79860 29391034
Epstein-Barr virus infection 199.72 9.99 174 103459 6455 29464439
Fatigue 189.94 9.99 530 103103 316291 29154603
Dizziness 174.02 9.99 247 103386 189437 29281457
Polyomavirus-associated nephropathy 173.91 9.99 122 103511 3274 29467620
Cytomegalovirus viraemia 172.73 9.99 157 103476 6163 29464731
Cytomegalovirus infection reactivation 172.62 9.99 121 103512 3243 29467651
Fall 171.32 9.99 222 103411 176956 29293938
Graft versus host disease in gastrointestinal tract 169.08 9.99 118 103515 3140 29467754
Septic shock 159.35 9.99 532 103101 62028 29408866
Adenovirus infection 157.19 9.99 128 103505 4319 29466575
Complications of transplanted kidney 146.53 9.99 117 103516 3837 29467057
Thrombotic microangiopathy 136.12 9.99 160 103473 8521 29462373
Nausea 134.65 9.99 540 103093 288715 29182179
Product dose omission issue 129.01 9.99 90 103543 96293 29374601
Pneumonia cytomegaloviral 127.31 9.99 92 103541 2590 29468304
Infusion related reaction 126.06 9.99 389 103244 43497 29427397
Candida infection 125.77 9.99 206 103427 15019 29455875
Acute graft versus host disease in skin 118.03 9.99 111 103522 4553 29466341
Cardiac failure congestive 117.19 9.99 61 103572 76520 29394374
BK virus infection 115.26 9.99 110 103523 4597 29466297
Cystitis haemorrhagic 114.50 9.99 111 103522 4731 29466163
Enterococcal infection 114.34 9.99 143 103490 8125 29462769
Nocardiosis 113.47 9.99 93 103540 3167 29467727
Toxicity to various agents 111.70 9.99 280 103353 173381 29297513
Klebsiella infection 111.17 9.99 133 103500 7216 29463678
Asthenia 110.34 9.99 386 103247 214864 29256030
Syncope 107.54 9.99 77 103556 81294 29389600
Haemophagocytic lymphohistiocytosis 106.17 9.99 156 103477 10348 29460546
Parvovirus B19 infection 104.59 9.99 51 103582 673 29470221
Pseudomonas infection 103.71 9.99 157 103476 10695 29460199
Acute graft versus host disease 102.56 9.99 114 103519 5710 29465184
Pneumatosis intestinalis 101.17 9.99 86 103547 3083 29467811
Cytomegalovirus test positive 97.41 9.99 87 103546 3336 29467558
Steroid diabetes 96.28 9.99 65 103568 1636 29469258
Myocardial infarction 95.74 9.99 149 103484 110147 29360747
Graft versus host disease in skin 94.41 9.99 85 103548 3294 29467600
Drug resistance 92.00 9.99 221 103412 21319 29449575
Disseminated mucormycosis 87.29 9.99 36 103597 310 29470584
Cytomegalovirus colitis 87.12 9.99 71 103562 2398 29468496
Constipation 85.67 9.99 169 103464 113991 29356903
Cerebrovascular accident 85.44 9.99 86 103547 76825 29394069
Acute graft versus host disease in liver 85.12 9.99 55 103578 1283 29469611
Delayed graft function 84.46 9.99 63 103570 1864 29469030
Human herpesvirus 6 infection 84.11 9.99 62 103571 1801 29469093
Blood pressure fluctuation 83.77 9.99 203 103430 19691 29451203
Pneumomediastinum 82.81 9.99 60 103573 1696 29469198
Progressive multifocal leukoencephalopathy 81.70 9.99 125 103508 8594 29462300
Dehydration 80.10 9.99 177 103456 114571 29356323
Focal segmental glomerulosclerosis 79.03 9.99 59 103574 1748 29469146
Nephropathy toxic 77.55 9.99 137 103496 10619 29460275
Hospitalisation 77.50 9.99 32 103601 45956 29424938
Renal tubular atrophy 76.79 9.99 47 103586 994 29469900
Chronic allograft nephropathy 76.12 9.99 48 103585 1072 29469822
Vomiting 72.19 9.99 442 103191 211818 29259076
Intentional overdose 71.36 9.99 23 103610 38505 29432389
Chronic graft versus host disease 71.18 9.99 79 103554 3950 29466944
Hypoglycaemia 70.32 9.99 41 103592 48305 29422589
Pneumocystis jirovecii infection 69.48 9.99 50 103583 1398 29469496
Lymphocyte count decreased 68.03 9.99 184 103449 19087 29451807
Lymphopenia 67.92 9.99 148 103485 13385 29457509
Overdose 67.18 9.99 110 103523 79709 29391185
Herpes simplex 66.69 9.99 84 103549 4806 29466088
Liver transplant rejection 65.96 9.99 55 103578 1919 29468975
Fungal infection 65.67 9.99 147 103486 13538 29457356
Pulmonary mucormycosis 62.44 9.99 33 103600 521 29470373
Mycobacterium chelonae infection 62.32 9.99 34 103599 574 29470320
Depression 62.18 9.99 128 103505 85019 29385875
Acute graft versus host disease in intestine 61.71 9.99 57 103576 2284 29468610
Confusional state 61.64 9.99 235 103398 127642 29343252
Enterobacter infection 60.47 9.99 53 103580 1981 29468913
Disseminated intravascular coagulation 59.10 9.99 179 103454 19801 29451093
Bacterial sepsis 58.21 9.99 77 103556 4626 29466268
Kidney fibrosis 58.19 9.99 52 103581 1995 29468899
Acute respiratory distress syndrome 57.39 9.99 194 103439 22741 29448153
Large intestine perforation 56.03 9.99 96 103537 7260 29463634
Infection reactivation 53.22 9.99 38 103595 1049 29469845
Coronary artery disease 53.07 9.99 46 103587 44144 29426750
Leukopenia 52.89 9.99 353 103280 54850 29416044
Immunosuppressant drug level increased 52.89 9.99 74 103559 4691 29466203
Aplasia 52.58 9.99 68 103565 3995 29466899
Cytomegalovirus enteritis 52.08 9.99 27 103606 409 29470485
Feeling abnormal 51.68 9.99 69 103564 54376 29416518
Sepsis 51.59 9.99 743 102890 141939 29328955
Myopathy 51.50 9.99 114 103519 10419 29460475
Phaeohyphomycosis 51.18 9.99 33 103600 767 29470127
Therapy non-responder 50.83 9.99 229 103404 30682 29440212
Rebound effect 50.74 9.99 48 103585 1983 29468911
Pneumonia pseudomonal 50.56 9.99 60 103573 3227 29467667
Cushingoid 50.47 9.99 52 103581 2386 29468508
Necrotising retinitis 49.92 9.99 32 103601 736 29470158
Cytomegalovirus chorioretinitis 49.63 9.99 59 103574 3179 29467715
Injection site pain 49.37 9.99 26 103607 32420 29438474
Decreased appetite 49.16 9.99 303 103330 145039 29325855
Pneumonia fungal 48.83 9.99 79 103554 5698 29465196
Intentional product use issue 47.06 9.99 282 103351 42216 29428678
Transplant failure 47.04 9.99 54 103579 2802 29468092
Transplant dysfunction 46.24 9.99 48 103585 2222 29468672
Central nervous system fungal infection 46.22 9.99 23 103610 318 29470576
Acinetobacter infection 46.11 9.99 34 103599 988 29469906
Symptom masked 46.07 9.99 27 103606 526 29470368
Oxygen saturation decreased 45.88 9.99 292 103341 44645 29426249
JC virus infection 45.81 9.99 44 103589 1853 29469041
Anxiety 45.70 9.99 150 103483 85215 29385679
Rhabdomyolysis 45.59 9.99 90 103543 60718 29410176
Renal transplant failure 45.02 9.99 33 103600 950 29469944
Cryptococcosis 44.75 9.99 44 103589 1908 29468986
Disease recurrence 44.67 9.99 140 103493 15774 29455120
Viraemia 44.60 9.99 34 103599 1040 29469854
Systemic mycosis 44.54 9.99 37 103596 1284 29469610
Cardiac disorder 44.49 9.99 39 103594 37224 29433670
COVID-19 pneumonia 44.25 9.99 101 103532 9421 29461473
Dyspnoea 43.99 9.99 844 102789 325888 29145006
Wrong technique in product usage process 43.82 9.99 28 103605 31400 29439494
Amoebic colitis 43.58 9.99 15 103618 73 29470821
Blood pressure diastolic abnormal 43.32 9.99 49 103584 2502 29468392
Epstein-Barr virus associated lymphoproliferative disorder 43.28 9.99 41 103592 1697 29469197
Skin necrosis 42.99 9.99 69 103564 4943 29465951
Product prescribing error 42.90 9.99 6 103627 17970 29452924
Hyperglycaemia 42.87 9.99 235 103398 34052 29436842
Suicide attempt 42.82 9.99 34 103599 34076 29436818
Proteinuria 42.50 9.99 137 103496 15667 29455227
Muscle spasms 42.47 9.99 104 103529 64978 29405916
Fusarium infection 42.37 9.99 32 103601 965 29469929
COVID-19 41.83 9.99 242 103391 35772 29435122
Pain 41.60 9.99 392 103241 171040 29299854
Epstein-Barr viraemia 40.70 9.99 31 103602 947 29469947
Somnolence 40.65 9.99 180 103453 93775 29377119
Incision site pain 40.52 9.99 40 103593 1743 29469151
Pneumothorax 40.51 9.99 135 103498 15707 29455187
Chorioretinopathy 40.31 9.99 36 103597 1380 29469514
Mycobacterium abscessus infection 40.03 9.99 23 103610 431 29470463
Graft versus host disease in liver 39.95 9.99 32 103601 1054 29469840
Dural arteriovenous fistula 39.88 9.99 12 103621 34 29470860
Escherichia infection 39.82 9.99 79 103554 6685 29464209
Glomerulosclerosis 39.53 9.99 27 103606 693 29470201
Diffuse alveolar damage 39.48 9.99 42 103591 2001 29468893
Renal tubular necrosis 39.32 9.99 125 103508 14190 29456704
Serotonin syndrome 39.18 9.99 7 103626 17505 29453389
Cytomegalovirus oesophagitis 39.17 9.99 22 103611 394 29470500
Hypoalbuminaemia 39.01 9.99 101 103532 10204 29460690
Staphylococcal sepsis 38.99 9.99 92 103541 8770 29462124
Penicillium infection 38.68 9.99 14 103619 81 29470813
Tremor 38.14 9.99 131 103502 73407 29397487
Aggression 38.02 9.99 41 103592 35500 29435394
Malaise 37.84 9.99 367 103266 159235 29311659
Oliguria 37.12 9.99 81 103552 7331 29463563
Pyrexia 36.64 9.99 1290 102343 286332 29184562
Diffuse large B-cell lymphoma 36.59 9.99 73 103560 6203 29464691
Pathogen resistance 36.52 9.99 85 103548 8031 29462863
Pneumonia acinetobacter 36.39 9.99 13 103620 72 29470822
Balance disorder 36.23 9.99 44 103589 36126 29434768
Oedema peripheral 35.97 9.99 214 103419 103343 29367551
Cutaneous mucormycosis 35.84 9.99 14 103619 103 29470791
Blood pressure systolic abnormal 35.83 9.99 41 103592 2120 29468774
Human herpesvirus 8 infection 35.59 9.99 27 103606 820 29470074
Pneumonia cryptococcal 35.42 9.99 26 103607 750 29470144
Varicella zoster virus infection 35.36 9.99 34 103599 1434 29469460
Red blood cells urine positive 35.21 9.99 36 103597 1637 29469257
Glomerulonephritis 34.72 9.99 36 103597 1664 29469230
Back pain 34.67 9.99 213 103420 102071 29368823
Lung abscess 34.44 9.99 42 103591 2324 29468570
Atrial fibrillation 34.27 9.99 223 103410 105423 29365471
Product quality issue 34.19 9.99 7 103626 15888 29455006
Full blood count abnormal 33.59 9.99 6 103627 15007 29455887
Rheumatoid arthritis 33.48 9.99 210 103423 31942 29438952
Lethargy 33.30 9.99 50 103583 37530 29433364
Insomnia 33.22 9.99 179 103454 88582 29382312
Opportunistic infection 33.09 9.99 33 103600 1456 29469438
Pulmonary nocardiosis 32.89 9.99 22 103611 545 29470349
Loss of personal independence in daily activities 32.38 9.99 25 103608 25415 29445479
Blood pressure increased 32.29 9.99 398 103235 73405 29397489
Cytomegalovirus enterocolitis 32.15 9.99 25 103608 788 29470106
Immunosuppressant drug level decreased 32.09 9.99 29 103604 1129 29469765
Osteomyelitis fungal 31.91 9.99 16 103617 225 29470669
Condition aggravated 31.81 9.99 703 102930 145592 29325302
Disseminated cryptococcosis 31.67 9.99 29 103604 1149 29469745
Pneumoperitoneum 31.57 9.99 33 103600 1540 29469354
Protein urine present 31.55 9.99 58 103575 4636 29466258
Bronchopneumopathy 31.41 9.99 19 103614 393 29470501
International normalised ratio increased 31.28 9.99 68 103565 44304 29426590
Gastroenteritis norovirus 31.14 9.99 31 103602 1365 29469529
Pulmonary alveolar haemorrhage 31.13 9.99 69 103564 6311 29464583
Perinephric abscess 31.02 9.99 10 103623 38 29470856
Cytomegalovirus hepatitis 30.95 9.99 17 103616 291 29470603
Fungal skin infection 30.82 9.99 40 103593 2358 29468536
Diarrhoea 30.70 9.99 910 102723 331788 29139106
Bradycardia 30.69 9.99 122 103511 65507 29405387
Low birth weight baby 30.61 9.99 70 103563 6538 29464356
Disseminated strongyloidiasis 30.30 9.99 12 103621 92 29470802
Contraindicated product administered 30.30 9.99 13 103620 18253 29452641
Diabetes mellitus 30.26 9.99 241 103392 39590 29431304
Stress 30.15 9.99 19 103614 21471 29449423
Myalgia 30.11 9.99 145 103488 73874 29397020
Adenoviral hepatitis 30.04 9.99 15 103618 209 29470685
Parvovirus infection 29.91 9.99 19 103614 430 29470464
Granulomatosis with polyangiitis 29.77 9.99 25 103608 881 29470013
Plasma cell myeloma 29.51 9.99 53 103580 37062 29433832
Chest pain 29.33 9.99 251 103382 111722 29359172
Antineutrophil cytoplasmic antibody positive 29.09 9.99 21 103612 590 29470304
Fungaemia 29.00 9.99 37 103596 2144 29468750
Intensive care unit acquired weakness 28.90 9.99 25 103608 918 29469976
Aplastic anaemia 28.84 9.99 74 103559 7436 29463458
Hallucination 28.73 9.99 72 103561 44640 29426254
Renal graft infection 28.48 9.99 15 103618 235 29470659
Rhinocerebral mucormycosis 28.43 9.99 15 103618 236 29470658
Dysphagia 27.69 9.99 99 103534 54827 29416067
Osteonecrosis 27.57 9.99 107 103526 13412 29457482
Respiratory arrest 27.41 9.99 30 103603 25803 29445091
Headache 27.32 9.99 437 103196 173570 29297324
Vasculitis 27.28 9.99 75 103558 7853 29463041
Suicidal ideation 27.22 9.99 50 103583 34666 29436228
Angiosarcoma 27.14 9.99 15 103618 260 29470634
Dry skin 27.09 9.99 25 103608 23282 29447612
Transient ischaemic attack 27.00 9.99 25 103608 23245 29447649
Enterococcal bacteraemia 26.98 9.99 30 103603 1503 29469391
Cholelithiasis 26.91 9.99 16 103617 18656 29452238
Accidental overdose 26.91 9.99 14 103619 17579 29453315
Intestinal ischaemia 26.80 9.99 67 103566 6625 29464269
Human polyomavirus infection 26.79 9.99 21 103612 670 29470224
Blood pressure systolic increased 26.35 9.99 123 103510 16722 29454172
Scopulariopsis infection 26.35 9.99 11 103622 98 29470796
Unevaluable event 26.17 9.99 40 103593 29811 29441083
Mixed liver injury 26.03 9.99 34 103599 2017 29468877
Inappropriate schedule of product administration 26.02 9.99 75 103558 44397 29426497
Contusion 26.00 9.99 43 103590 31052 29439842
Treatment noncompliance 25.85 9.99 28 103605 24199 29446695
Leukocytosis 25.81 9.99 144 103489 20998 29449896
Gastrointestinal candidiasis 25.61 9.99 12 103621 144 29470750
Arrhythmia 25.54 9.99 44 103589 31269 29439625
Epstein-Barr virus associated lymphoma 25.50 9.99 19 103614 561 29470333
American trypanosomiasis 25.47 9.99 14 103619 240 29470654
Abdominal abscess 25.39 9.99 47 103586 3777 29467117
Ureteric stenosis 25.29 9.99 25 103608 1091 29469803
Obliterative bronchiolitis 25.29 9.99 25 103608 1091 29469803
Depressed mood 25.29 9.99 13 103620 16435 29454459
Dyskinesia 25.17 9.99 20 103613 20041 29450853
Erectile dysfunction 25.16 9.99 16 103617 17993 29452901
Haemolytic uraemic syndrome 25.14 9.99 33 103600 1967 29468927
Staphylococcal infection 25.06 9.99 182 103451 29058 29441836
Extrapyramidal disorder 24.96 9.99 4 103629 10827 29460067
Respiratory tract infection fungal 24.91 9.99 20 103613 661 29470233
Systemic candida 24.85 9.99 39 103594 2741 29468153
Accidental exposure to product 24.71 9.99 4 103629 10749 29460145
Klebsiella sepsis 24.69 9.99 30 103603 1654 29469240
Lymphangitis 24.65 9.99 18 103615 515 29470379
Drug interaction 24.63 9.99 516 103117 196869 29274025
Reticulocytosis 24.53 9.99 14 103619 259 29470635
Cryptococcal meningoencephalitis 24.48 9.99 11 103622 119 29470775
Pneumoretroperitoneum 24.32 9.99 9 103624 56 29470838
Restlessness 24.30 9.99 25 103608 22120 29448774
Osteoporosis 24.26 9.99 88 103545 10681 29460213
Inflammatory marker increased 24.26 9.99 45 103588 3622 29467272
Splenic embolism 24.24 9.99 12 103621 164 29470730
Immune reconstitution inflammatory syndrome 24.11 9.99 71 103562 7731 29463163
Tuberculosis 23.70 9.99 67 103566 7129 29463765
Gait disturbance 23.68 9.99 155 103478 73194 29397700
Hepatic failure 23.57 9.99 190 103443 31322 29439572
Apoptosis 23.54 9.99 13 103620 225 29470669
Hypogammaglobulinaemia 23.51 9.99 59 103574 5848 29465046
Hepatic artery thrombosis 23.34 9.99 13 103620 229 29470665
Corynebacterium infection 23.24 9.99 16 103617 416 29470478
Hyperhidrosis 23.13 9.99 132 103501 64408 29406486
Escherichia sepsis 23.10 9.99 46 103587 3903 29466991
Lupus nephritis 23.09 9.99 13 103620 234 29470660
Peripheral swelling 23.04 9.99 130 103503 63609 29407285
Osmotic demyelination syndrome 22.93 9.99 19 103614 657 29470237
Intentional product misuse 22.91 9.99 55 103578 34606 29436288
Pain in extremity 22.87 9.99 262 103371 110171 29360723
Prostate cancer 22.58 9.99 34 103599 25493 29445401
Treatment failure 22.56 9.99 213 103420 36726 29434168
Intra-abdominal haemorrhage 22.46 9.99 32 103601 2063 29468831
Herpes simplex viraemia 22.39 9.99 9 103624 72 29470822
Skin striae 22.37 9.99 16 103617 443 29470451
Blood beta-D-glucan increased 22.10 9.99 15 103618 381 29470513
Blood creatine phosphokinase increased 22.02 9.99 71 103562 40573 29430321
Monocytopenia 21.97 9.99 9 103624 76 29470818
Herpes zoster meningoencephalitis 21.97 9.99 13 103620 258 29470636
Lymphoproliferative disorder 21.96 9.99 35 103598 2492 29468402
Cavernous sinus thrombosis 21.86 9.99 11 103622 156 29470738
Sideroblastic anaemia 21.82 9.99 12 103621 206 29470688
Laboratory test abnormal 21.74 9.99 19 103614 18166 29452728
Neuroleptic malignant syndrome 21.68 9.99 15 103618 16133 29454761
Listeriosis 21.62 9.99 21 103612 897 29469997
Cystitis escherichia 21.61 9.99 11 103622 160 29470734
Multi-organ disorder 21.58 9.99 23 103610 1098 29469796
Dermatophytosis 21.56 9.99 12 103621 211 29470683
Pyelonephritis acute 21.50 9.99 28 103605 1656 29469238
Drug effective for unapproved indication 21.46 9.99 26 103607 1429 29469465
Diaphragmatic injury 21.35 9.99 10 103623 120 29470774
Immunosuppression 21.25 9.99 53 103580 5233 29465661
Graft complication 21.24 9.99 14 103619 338 29470556
Graft loss 21.11 9.99 20 103613 828 29470066
Device related sepsis 20.92 9.99 34 103599 2461 29468433
Nightmare 20.81 9.99 7 103626 11410 29459484
Pemphigus 20.80 9.99 23 103610 1145 29469749
Unresponsive to stimuli 20.77 9.99 35 103598 25091 29445803
Torulopsis infection 20.77 9.99 6 103627 14 29470880
Red blood cell schistocytes present 20.65 9.99 12 103621 230 29470664
Bursitis infective 20.58 9.99 16 103617 504 29470390
Agitation 20.57 9.99 101 103532 51203 29419691
Gonococcal infection 20.35 9.99 7 103626 34 29470860
Mobility decreased 20.32 9.99 37 103596 25743 29445151
Poisoning 20.29 9.99 5 103628 9988 29460906
Neutrophil percentage increased 20.27 9.99 28 103605 1753 29469141
Atypical mycobacterial pneumonia 20.18 9.99 10 103623 137 29470757
Injection site reaction 20.15 9.99 7 103626 11181 29459713
Bronchopleural fistula 20.13 9.99 15 103618 443 29470451
Hepatitis E 20.09 9.99 27 103606 1647 29469247
Exposure during pregnancy 20.07 9.99 3 103630 8551 29462343
Amoebiasis 20.01 9.99 8 103625 63 29470831
Central nervous system infection 20.00 9.99 16 103617 526 29470368
Therapy cessation 20.00 9.99 13 103620 14449 29456445
Full blood count decreased 19.99 9.99 16 103617 15976 29454918
Lymphocele 19.97 9.99 24 103609 1308 29469586
Urine abnormality 19.84 9.99 27 103606 1667 29469227
Product substitution issue 19.81 9.99 4 103629 9168 29461726
Bacteraemia 19.81 9.99 111 103522 16212 29454682
Urine analysis abnormal 19.80 9.99 28 103605 1792 29469102
Graft infection 19.78 9.99 14 103619 381 29470513
Necrosis 19.76 9.99 50 103583 4980 29465914
Bordetella infection 19.74 9.99 9 103624 101 29470793
Seronegative arthritis 19.66 9.99 20 103613 904 29469990
Cerebral aspergillosis 19.62 9.99 24 103609 1332 29469562
Endocarditis 19.59 9.99 54 103579 5662 29465232
Peritonitis 19.47 9.99 103 103530 14721 29456173
Thrombocytopenia 19.46 9.99 614 103019 134209 29336685
Complications of transplant surgery 19.39 9.99 15 103618 469 29470425
Trichophytosis 19.27 9.99 12 103621 262 29470632
Pneumonia adenoviral 19.26 9.99 10 103623 152 29470742
Listeria sepsis 19.20 9.99 10 103623 153 29470741
Asthma 19.14 9.99 58 103575 33791 29437103
Disseminated trichosporonosis 18.99 9.99 7 103626 43 29470851
Dyspepsia 18.97 9.99 49 103584 30076 29440818
Cutaneous malacoplakia 18.85 9.99 7 103626 44 29470850
Pseudomonal bacteraemia 18.81 9.99 20 103613 952 29469942
Cytomegalovirus nephritis 18.78 9.99 9 103624 114 29470780
Injection site erythema 18.69 9.99 13 103620 13943 29456951
Injection site swelling 18.57 9.99 5 103628 9412 29461482
Gastrointestinal perforation 18.52 9.99 39 103594 3444 29467450
Marrow hyperplasia 18.49 9.99 20 103613 971 29469923
Swollen tongue 18.41 9.99 10 103623 12256 29458638
B-lymphocyte count decreased 18.29 9.99 15 103618 511 29470383
Necrosis ischaemic 18.21 9.99 11 103622 227 29470667
Hepatitis A 18.20 9.99 14 103619 434 29470460
Leishmaniasis 18.16 9.99 12 103621 291 29470603
Hypertension 18.14 9.99 536 103097 116078 29354816
Pruritus 18.13 9.99 294 103339 116555 29354339
Cardiac arrest 18.13 9.99 202 103431 85389 29385505
Cerebral fungal infection 18.12 9.99 11 103622 229 29470665
Gastritis fungal 18.01 9.99 8 103625 84 29470810
Haemolytic anaemia 17.96 9.99 73 103560 9346 29461548
Herpes simplex hepatitis 17.93 9.99 8 103625 85 29470809
Megacolon 17.92 9.99 25 103608 1580 29469314
Respiratory disorder 17.72 9.99 111 103522 16872 29454022
Multiple-drug resistance 17.71 9.99 41 103592 3859 29467035
Cutaneous nocardiosis 17.68 9.99 9 103624 131 29470763
Epstein-Barr virus infection reactivation 17.66 9.99 15 103618 537 29470357
Enterococcus test positive 17.66 9.99 17 103616 718 29470176
Cytomegalovirus gastrointestinal infection 17.61 9.99 10 103623 183 29470711
Disseminated blastomycosis 17.61 9.99 8 103625 89 29470805
Sedation 17.61 9.99 21 103612 17384 29453510
IgA nephropathy 17.42 9.99 20 103613 1038 29469856
Accelerated idioventricular rhythm 17.38 9.99 8 103625 92 29470802
Arterial spasm 17.38 9.99 8 103625 92 29470802
Wheezing 17.36 9.99 59 103574 33181 29437713
Hypersomnia 17.29 9.99 8 103625 10746 29460148
Irritability 17.28 9.99 32 103601 22120 29448774
Adenoviral haemorrhagic cystitis 17.27 9.99 13 103620 390 29470504
Granuloma 17.26 9.99 31 103602 2433 29468461
Quadriplegia 17.26 9.99 24 103609 1512 29469382
Kidney rupture 17.24 9.99 10 103623 191 29470703
Meningitis fungal 17.22 9.99 8 103625 94 29470800
Abdominal discomfort 17.14 9.99 98 103535 47805 29423089
Bacterial infection 17.02 9.99 90 103543 12858 29458036
Encephalitis cytomegalovirus 17.00 9.99 14 103619 480 29470414
Malignant neoplasm progression 16.98 9.99 171 103462 73688 29397206
Smooth muscle cell neoplasm 16.98 9.99 9 103624 143 29470751
Blood sodium decreased 16.97 9.99 16 103617 14751 29456143
Hepatitis cholestatic 16.97 9.99 58 103575 6835 29464059
Herpes simplex colitis 16.93 9.99 5 103628 13 29470881
Post procedural urine leak 16.92 9.99 9 103624 144 29470750
Pancytopenia 16.90 9.99 396 103237 82772 29388122
Porphyria acute 16.87 9.99 10 103623 199 29470695
Polychondritis 16.87 9.99 9 103624 145 29470749
Acne fulminans 16.87 9.99 9 103624 145 29470749
Viral cardiomyopathy 16.83 9.99 6 103627 33 29470861
Disseminated tuberculosis 16.81 9.99 27 103606 1935 29468959
Loss of consciousness 16.80 9.99 172 103461 73884 29397010
Hyperkalaemia 16.79 9.99 136 103497 61256 29409638
Coma 16.79 9.99 76 103557 39374 29431520
Drug intolerance 16.77 9.99 100 103533 48279 29422615
Subcutaneous emphysema 16.75 9.99 19 103614 973 29469921
Uraemic encephalopathy 16.75 9.99 11 103622 264 29470630
Toxic epidermal necrolysis 16.72 9.99 115 103518 18038 29452856
Acute endocarditis 16.66 9.99 5 103628 14 29470880
Chemotherapeutic drug level above therapeutic 16.66 9.99 5 103628 14 29470880
Pleural mass 16.51 9.99 7 103626 65 29470829
Orthostatic hypotension 16.51 9.99 34 103599 22595 29448299
Activated partial thromboplastin time shortened 16.50 9.99 13 103620 418 29470476
Foetal growth restriction 16.46 9.99 39 103594 3727 29467167
Secondary immunodeficiency 16.44 9.99 12 103621 343 29470551
Hypophagia 16.41 9.99 30 103603 20842 29450052
Heart rate decreased 16.40 9.99 146 103487 24766 29446128
Necrotising oesophagitis 16.32 9.99 14 103619 508 29470386
Miosis 16.28 9.99 4 103629 8005 29462889
Herpes zoster 16.27 9.99 169 103464 29883 29441011
Lymphocyte percentage decreased 16.26 9.99 27 103606 1990 29468904
Intestine transplant rejection 16.26 9.99 6 103627 37 29470857
Fungal endocarditis 16.25 9.99 11 103622 278 29470616
Pneumonia escherichia 16.18 9.99 12 103621 352 29470542
Eschar 16.11 9.99 15 103618 607 29470287
Steroid withdrawal syndrome 16.11 9.99 10 103623 217 29470677
Aplasia pure red cell 16.05 9.99 49 103584 5442 29465452
Neuromyelitis optica spectrum disorder 15.99 9.99 8 103625 112 29470782
Herpes zoster cutaneous disseminated 15.98 9.99 9 103624 162 29470732
Dehiscence 15.98 9.99 7 103626 71 29470823
Adverse event 15.95 9.99 18 103615 15273 29455621
Chimerism 15.95 9.99 10 103623 221 29470673
Blood immunoglobulin G decreased 15.95 9.99 20 103613 1139 29469755
Steroid dependence 15.95 9.99 11 103622 287 29470607
Urobilinogen urine increased 15.94 9.99 12 103621 360 29470534
Limbic encephalitis 15.94 9.99 12 103621 360 29470534
Pneumonia bacterial 15.94 9.99 70 103563 9273 29461621
Bifidobacterium infection 15.94 9.99 5 103628 17 29470877
Haematopoietic stem cell mobilisation 15.89 9.99 9 103624 164 29470730
Fluid retention 15.87 9.99 37 103596 23523 29447371
Cerebral venous thrombosis 15.79 9.99 15 103618 623 29470271
Blood pressure decreased 15.76 9.99 94 103539 45383 29425511
Haemodynamic instability 15.74 9.99 63 103570 8010 29462884
Psoriatic arthropathy 15.65 9.99 17 103616 14674 29456220
Liver function test 15.62 9.99 6 103627 42 29470852
Incorrect dose administered 15.61 9.99 61 103572 32923 29437971
Vision blurred 15.59 9.99 80 103553 40096 29430798
Peritoneal candidiasis 15.51 9.99 5 103628 19 29470875
Morganella infection 15.48 9.99 13 103620 458 29470436
Encephalitis brain stem 15.48 9.99 7 103626 77 29470817
Blood immunoglobulin M decreased 15.47 9.99 12 103621 377 29470517
Herpes virus infection 15.43 9.99 30 103603 2501 29468393
Arteriosclerosis coronary artery 15.40 9.99 9 103624 10596 29460298
Ureteric anastomosis complication 15.38 9.99 6 103627 44 29470850
Encephalitis fungal 15.37 9.99 9 103624 175 29470719
Medication error 15.37 9.99 32 103601 21179 29449715
Nephrotic syndrome 15.36 9.99 53 103580 6275 29464619
Subcapsular renal haematoma 15.33 9.99 12 103621 382 29470512
Pneumonia influenzal 15.28 9.99 21 103612 1309 29469585
Splenic necrosis 15.26 9.99 6 103627 45 29470849
Spermatozoa progressive motility decreased 15.04 9.99 8 103625 128 29470766
Disseminated varicella zoster vaccine virus infection 15.04 9.99 6 103627 47 29470847
Dysgeusia 14.96 9.99 36 103597 22638 29448256
Scedosporium infection 14.92 9.99 16 103617 769 29470125
Intentional self-injury 14.92 9.99 13 103620 12448 29458446
Paranoia 14.90 9.99 8 103625 9869 29461025
Encephalitis 14.87 9.99 53 103580 6377 29464517
Acute myocardial infarction 14.81 9.99 104 103529 48334 29422560
Oral herpes 14.73 9.99 42 103591 4490 29466404
Small intestinal perforation 14.73 9.99 23 103610 1609 29469285
Pulmonary haemorrhage 14.73 9.99 68 103565 9202 29461692
Faeces discoloured 14.73 9.99 15 103618 13336 29457558
Glomerulonephropathy 14.72 9.99 9 103624 190 29470704
Arteritis coronary 14.62 9.99 6 103627 51 29470843
Chronic papillomatous dermatitis 14.62 9.99 6 103627 51 29470843
Dyspnoea exertional 14.53 9.99 72 103561 36418 29434476
Peliosis hepatis 14.51 9.99 6 103627 52 29470842
Salivary hypersecretion 14.48 9.99 4 103629 7405 29463489
Cytokine release syndrome 14.48 9.99 87 103546 13032 29457862
Wolff-Parkinson-White syndrome 14.47 9.99 9 103624 196 29470698
Visceral leishmaniasis 14.45 9.99 13 103620 503 29470391
Arthritis fungal 14.45 9.99 7 103626 91 29470803
Akathisia 14.44 9.99 3 103630 6739 29464155
Tularaemia 14.38 9.99 7 103626 92 29470802
Psoriasis 14.37 9.99 61 103572 32166 29438728
Hypoaesthesia 14.37 9.99 119 103514 53348 29417546
Lymphocytosis 14.36 9.99 25 103608 1915 29468979
Optic nerve compression 14.26 9.99 4 103629 8 29470886
Ophthalmoplegia 14.21 9.99 23 103610 1659 29469235
Angina pectoris 14.16 9.99 50 103583 27800 29443094
Acinetobacter bacteraemia 14.12 9.99 7 103626 96 29470798
Neuropathy peripheral 14.11 9.99 170 103463 70857 29400037
Diffuse mesangial sclerosis 14.10 9.99 5 103628 27 29470867
Febrile bone marrow aplasia 14.04 9.99 57 103576 7294 29463600
Viral load abnormal 13.95 9.99 6 103627 58 29470836
Granulomatous liver disease 13.91 9.99 13 103620 529 29470365
Pleuropericarditis 13.89 9.99 9 103624 211 29470683
Angioedema 13.87 9.99 61 103572 31854 29439040
Stenotrophomonas infection 13.86 9.99 23 103610 1694 29469200
Injection site haemorrhage 13.86 9.99 6 103627 8380 29462514
Biopsy lymph gland 13.86 9.99 6 103627 59 29470835
Pericarditis fungal 13.83 9.99 8 103625 152 29470742
Blood pressure diastolic increased 13.82 9.99 36 103597 3650 29467244
Thyroiditis subacute 13.80 9.99 5 103628 29 29470865
Pneumonia necrotising 13.74 9.99 13 103620 537 29470357
West Nile viral infection 13.70 9.99 14 103619 636 29470258
Kaposi's sarcoma 13.70 9.99 16 103617 846 29470048
Glycosylated haemoglobin increased 13.69 9.99 8 103625 9418 29461476
Therapeutic product effect decreased 13.60 9.99 55 103578 29396 29441498
Infective tenosynovitis 13.60 9.99 6 103627 62 29470832
Arterial rupture 13.59 9.99 12 103621 453 29470441
Systemic inflammatory response syndrome 13.58 9.99 49 103584 5932 29464962
Bacillus infection 13.56 9.99 9 103624 220 29470674
Disseminated varicella zoster virus infection 13.55 9.99 8 103625 158 29470736
Central nervous system vasculitis 13.46 9.99 11 103622 373 29470521
Pseudomonal sepsis 13.44 9.99 31 103602 2911 29467983
Electrocardiogram QT prolonged 13.43 9.99 73 103560 36064 29434830
Herpes simplex meningoencephalitis 13.38 9.99 4 103629 11 29470883
Lower gastrointestinal haemorrhage 13.38 9.99 6 103627 8207 29462687
Pneumonia klebsiella 13.36 9.99 29 103604 2615 29468279
Urinary fistula 13.33 9.99 7 103626 109 29470785
Gastrointestinal ulcer 13.29 9.99 22 103611 1617 29469277
Diarrhoea haemorrhagic 13.23 9.99 48 103585 5826 29465068
Epididymitis 13.20 9.99 26 103607 2189 29468705
Skin discolouration 13.17 9.99 21 103612 15388 29455506
Drug withdrawal syndrome 13.14 9.99 27 103606 17957 29452937
Abdominal infection 13.10 9.99 20 103613 1372 29469522
Abnormal dreams 13.04 9.99 4 103629 6916 29463978
Adverse drug reaction 12.98 9.99 42 103591 23978 29446916
Fungal peritonitis 12.97 9.99 14 103619 678 29470216
Heart transplant rejection 12.96 9.99 18 103615 1133 29469761
Meningitis cryptococcal 12.94 9.99 25 103608 2075 29468819
Sleep disorder 12.93 9.99 43 103590 24343 29446551
Inadequate aseptic technique in use of product 12.89 9.99 4 103629 13 29470881
Alveolar proteinosis 12.84 9.99 10 103623 316 29470578
Fungal sepsis 12.83 9.99 15 103618 794 29470100
Premature baby 12.81 9.99 104 103529 17176 29453718
Enterobacter bacteraemia 12.78 9.99 10 103623 318 29470576
Epstein-Barr virus test positive 12.72 9.99 12 103621 494 29470400
Pancreas transplant rejection 12.71 9.99 8 103625 178 29470716
Pollakiuria 12.70 9.99 25 103608 16891 29454003
Lymphocytic infiltration 12.70 9.99 13 103620 592 29470302
Lipoma 12.68 9.99 20 103613 1411 29469483
Renal impairment 12.68 9.99 374 103259 80959 29389935
Immune thrombocytopenia 12.68 9.99 58 103575 7819 29463075
Meconium peritonitis 12.66 9.99 4 103629 14 29470880
Palatal ulcer 12.66 9.99 5 103628 38 29470856
Vitamin B1 decreased 12.65 9.99 9 103624 247 29470647
Stupor 12.63 9.99 29 103604 2715 29468179
Pseudopolyposis 12.55 9.99 5 103628 39 29470855
Amoebic dysentery 12.55 9.99 5 103628 39 29470855
Dry mouth 12.55 9.99 37 103596 21747 29449147
Transaminases increased 12.53 9.99 128 103505 22534 29448360
Haemoperitoneum 12.51 9.99 21 103612 1561 29469333
White blood cell count decreased 12.51 9.99 211 103422 83151 29387743
Chronic obstructive pulmonary disease 12.49 9.99 88 103545 40867 29430027
Myoclonus 12.49 9.99 17 103616 13292 29457602
Pelvic venous thrombosis 12.46 9.99 12 103621 507 29470387
Lung transplant rejection 12.45 9.99 14 103619 710 29470184
Acute disseminated encephalomyelitis 12.45 9.99 6 103627 77 29470817
Myocarditis infectious 12.45 9.99 4 103629 15 29470879
Radiotherapy to brain 12.44 9.99 5 103628 40 29470854
Urinary tract infection bacterial 12.41 9.99 20 103613 1438 29469456
Ageusia 12.40 9.99 8 103625 8930 29461964
Angiocentric lymphoma 12.40 9.99 9 103624 255 29470639
Crystal urine present 12.40 9.99 11 103622 418 29470476
Blindness cortical 12.34 9.99 10 103623 335 29470559
Muscle rigidity 12.29 9.99 9 103624 9402 29461492
Osteitis 12.29 9.99 20 103613 1449 29469445
Gastroenteritis rotavirus 12.29 9.99 8 103625 189 29470705
Carotid artery insufficiency 12.25 9.99 4 103629 16 29470878
Hypertensive encephalopathy 12.24 9.99 10 103623 339 29470555
Pulmonary fibrosis 12.22 9.99 95 103538 15487 29455407
Congenital cardiovascular anomaly 12.22 9.99 8 103625 191 29470703
Exophthalmos 12.21 9.99 12 103621 520 29470374
Panic attack 12.19 9.99 7 103626 8319 29462575
ADAMTS13 activity decreased 12.18 9.99 6 103627 81 29470813
Sputum purulent 12.18 9.99 11 103622 428 29470466
Ureaplasma infection 12.14 9.99 8 103625 193 29470701
Semen volume decreased 12.14 9.99 10 103623 343 29470551
Phaeohyphomycotic brain abscess 12.13 9.99 5 103628 43 29470851
Aortic pseudoaneurysm 12.13 9.99 5 103628 43 29470851
Lip haemorrhage 12.12 9.99 14 103619 731 29470163
Hyperplasia 12.12 9.99 12 103621 525 29470369
Cardio-respiratory arrest 12.11 9.99 116 103517 50485 29420409
Serum sickness 12.10 9.99 22 103611 1743 29469151
Trichosporon infection 12.09 9.99 13 103620 627 29470267
Hypocalcaemia 11.97 9.99 35 103598 20630 29450264
Splenic infection fungal 11.93 9.99 6 103627 85 29470809
Papillary muscle rupture 11.90 9.99 3 103630 3 29470891
Neonatal multi-organ failure 11.90 9.99 3 103630 3 29470891
Dystonia 11.88 9.99 10 103623 9739 29461155
Hemianopia 11.87 9.99 13 103620 640 29470254
Post procedural bile leak 11.87 9.99 9 103624 273 29470621
Autoimmune haemolytic anaemia 11.87 9.99 35 103598 3813 29467081
Colorectal adenocarcinoma 11.86 9.99 8 103625 201 29470693
Rash papulosquamous 11.84 9.99 5 103628 46 29470848
Memory impairment 11.80 9.99 77 103556 36393 29434501
Palmar-plantar erythrodysaesthesia syndrome 11.80 9.99 21 103612 14738 29456156
Bronchitis bacterial 11.79 9.99 13 103620 645 29470249
Colitis 11.76 9.99 164 103469 31084 29439810
Blood glucose decreased 11.75 9.99 15 103618 12054 29458840
Encephalopathy 11.72 9.99 163 103470 30880 29440014
Neurological symptom 11.71 9.99 32 103601 3338 29467556
Chronic hepatitis 11.71 9.99 12 103621 547 29470347
Gastrointestinal haemorrhage 11.71 9.99 202 103431 79331 29391563
Mucosal ulceration 11.71 9.99 15 103618 873 29470021
Inhibin B 11.70 9.99 4 103629 19 29470875
Optic atrophy 11.69 9.99 14 103619 760 29470134
Microsporidia infection 11.64 9.99 12 103621 551 29470343
Autoimmune colitis 11.64 9.99 15 103618 878 29470016
Neutrophil count increased 11.63 9.99 90 103543 14652 29456242
Shock haemorrhagic 11.62 9.99 65 103568 9486 29461408
Hypercapnia 11.60 9.99 34 103599 3692 29467202
Epstein Barr virus positive mucocutaneous ulcer 11.59 9.99 9 103624 283 29470611
Cytomegalovirus gastritis 11.55 9.99 8 103625 210 29470684
Ventricular extrasystoles 11.55 9.99 12 103621 10570 29460324
Restless legs syndrome 11.53 9.99 5 103628 6979 29463915
Infective aortitis 11.53 9.99 4 103629 20 29470874
Venous haemorrhage 11.53 9.99 4 103629 20 29470874
Eye abscess 11.48 9.99 7 103626 147 29470747
Complication of device removal 11.47 9.99 5 103628 50 29470844
Donor specific antibody present 11.39 9.99 6 103627 94 29470800
Intestinal ulcer 11.39 9.99 14 103619 781 29470113
Autoimmune thyroiditis 11.36 9.99 16 103617 1020 29469874
Eosinophil percentage decreased 11.34 9.99 6 103627 95 29470799
Amnesia 11.28 9.99 41 103592 22602 29448292
Fungal abscess central nervous system 11.28 9.99 6 103627 96 29470798
Fear 11.28 9.99 10 103623 9494 29461400
Adenomatous polyposis coli 11.27 9.99 7 103626 152 29470742
Nephrolithiasis 11.27 9.99 48 103585 25286 29445608
Coombs direct test positive 11.25 9.99 9 103624 296 29470598
Neck pain 11.25 9.99 38 103595 21409 29449485
Rash 11.24 9.99 547 103086 189272 29281622
Tumefactive multiple sclerosis 11.22 9.99 4 103629 22 29470872
Papilloedema 11.22 9.99 25 103608 2295 29468599
Disturbance in attention 11.21 9.99 38 103595 21386 29449508
Mycoplasma infection 11.17 9.99 9 103624 299 29470595
Organising pneumonia 11.16 9.99 41 103592 5007 29465887
Rectal haemorrhage 11.15 9.99 73 103560 34476 29436418
Erythema infectiosum 11.11 9.99 7 103626 156 29470738
Respiratory distress 11.09 9.99 166 103467 31940 29438954
Head injury 11.04 9.99 25 103608 16056 29454838
Viral haemorrhagic cystitis 11.03 9.99 15 103618 925 29469969
Thrombosis 11.03 9.99 97 103536 42948 29427946
Mouth ulceration 11.00 9.99 68 103565 10287 29460607
Tricuspid valve incompetence 11 9.99 8 103625 8386 29462508
Gastrooesophageal reflux disease 10.96 9.99 65 103568 31431 29439463
Capillaritis 10.96 9.99 6 103627 102 29470792
Central nervous system lesion 10.95 9.99 44 103589 5604 29465290
Electrocardiogram abnormal 10.94 9.99 6 103627 7316 29463578
Periventricular haemorrhage neonatal 10.93 9.99 4 103629 24 29470870
Abscess sterile 10.93 9.99 4 103629 24 29470870
Body height below normal 10.92 9.99 8 103625 230 29470664
Tubulointerstitial nephritis 10.90 9.99 102 103531 17541 29453353
Necrotising soft tissue infection 10.90 9.99 5 103628 57 29470837
Glomerulonephritis minimal lesion 10.86 9.99 10 103623 399 29470495
Seizure 10.84 9.99 246 103387 92877 29378017
Road traffic accident 10.84 9.99 24 103609 15537 29455357
Poikiloderma 10.81 9.99 7 103626 164 29470730
Hepatitis B 10.80 9.99 43 103590 5454 29465440
Unmasking of previously unidentified disease 10.79 9.99 13 103620 710 29470184
Renal cancer recurrent 10.79 9.99 4 103629 25 29470869
Hypocomplementaemia 10.79 9.99 4 103629 25 29470869
Perinephric collection 10.77 9.99 7 103626 165 29470729
Glomerulonephritis rapidly progressive 10.76 9.99 11 103622 500 29470394
Emphysematous cystitis 10.75 9.99 5 103628 59 29470835
Eye infection fungal 10.74 9.99 9 103624 316 29470578
Engraftment syndrome 10.74 9.99 14 103619 829 29470065
Drug eruption 10.72 9.99 27 103606 16714 29454180
Chorioretinal folds 10.70 9.99 3 103630 6 29470888
Idiopathic pneumonia syndrome 10.69 9.99 8 103625 238 29470656
Mycobacterium kansasii infection 10.69 9.99 8 103625 238 29470656
Acanthamoeba infection 10.67 9.99 10 103623 408 29470486
Capnocytophaga infection 10.67 9.99 5 103628 60 29470834
Tongue fungal infection 10.66 9.99 4 103629 26 29470868
Enterococcal sepsis 10.65 9.99 19 103614 1483 29469411
Neuromyotonia 10.53 9.99 4 103629 27 29470867
Bacterial pyelonephritis 10.51 9.99 8 103625 244 29470650
Bladder cancer 10.48 9.99 12 103621 10115 29460779
Brain oedema 10.43 9.99 76 103557 12144 29458750
Hilar lymphadenopathy 10.43 9.99 14 103619 853 29470041
Substance-induced psychotic disorder 10.42 9.99 18 103615 1370 29469524
Subperiosteal abscess 10.41 9.99 4 103629 28 29470866
Adrenal atrophy 10.39 9.99 3 103630 7 29470887
Candida sepsis 10.38 9.99 16 103617 1107 29469787
Tongue ulceration 10.34 9.99 16 103617 1111 29469783
Haptoglobin decreased 10.32 9.99 11 103622 525 29470369
Retinal detachment 10.31 9.99 38 103595 4648 29466246
Hepatic cirrhosis 10.29 9.99 22 103611 14422 29456472
Viral sepsis 10.25 9.99 5 103628 66 29470828
Polyomavirus viraemia 10.23 9.99 12 103621 637 29470257
Nephrogenic diabetes insipidus 10.21 9.99 16 103617 1123 29469771
Citrobacter infection 10.20 9.99 10 103623 432 29470462
Glucose tolerance impaired 10.18 9.99 27 103606 2767 29468127
Haematuria traumatic 10.17 9.99 7 103626 182 29470712
Haematemesis 10.15 9.99 48 103585 24578 29446316
Respiratory depression 10.14 9.99 20 103613 13503 29457391
Dental caries 10.14 9.99 35 103598 4145 29466749
Mycobacterial infection 10.12 9.99 21 103612 1835 29469059
Thyroid gland abscess 10.12 9.99 5 103628 68 29470826
Product storage error 10.12 9.99 5 103628 6465 29464429
Pancreatitis 10.12 9.99 75 103558 34439 29436455
Blood creatinine increased 10.10 9.99 379 103254 84723 29386171
Eye luxation 10.10 9.99 3 103630 8 29470886
Acinetobacter test positive 10.10 9.99 6 103627 120 29470774
SARS-CoV-2 RNA 10.06 9.99 4 103629 31 29470863
Abdominal wall disorder 10.06 9.99 4 103629 31 29470863
New onset diabetes after transplantation 10.06 9.99 4 103629 31 29470863
Neurological examination abnormal 10.05 9.99 8 103625 261 29470633
Neuromyopathy 10.03 9.99 14 103619 885 29470009
Brain abscess 10.03 9.99 26 103607 2629 29468265
Product administration error 10.02 9.99 22 103611 14288 29456606
Gait inability 10.02 9.99 32 103601 18343 29452551
Polychromasia 10.01 9.99 6 103627 122 29470772
Urinary retention 9.99 9.99 68 103565 31830 29439064

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cytomegalovirus infection 1331.78 9.45 1101 236603 36098 64224930
Off label use 1034.92 9.45 4834 232870 627972 63633056
Product use in unapproved indication 968.41 9.45 2060 235644 174558 64086470
Completed suicide 685.87 9.45 34 237670 224380 64036648
Drug ineffective for unapproved indication 537.88 9.45 618 237086 30515 64230513
Aspergillus infection 498.66 9.45 442 237262 15937 64245091
Infusion related reaction 482.57 9.45 1517 236187 162950 64098078
Transplant rejection 471.81 9.45 440 237264 16961 64244067
Bronchopulmonary aspergillosis 470.76 9.45 458 237246 18627 64242401
Mucormycosis 446.58 9.45 299 237405 7042 64253986
Posterior reversible encephalopathy syndrome 436.56 9.45 479 237225 22467 64238561
Drug ineffective 398.24 9.45 4781 232923 835466 63425562
Pneumocystis jirovecii pneumonia 394.59 9.45 498 237206 27136 64233892
Death 392.17 9.45 740 236964 481965 63779063
Kidney transplant rejection 381.44 9.45 301 237403 9210 64251818
Multiple organ dysfunction syndrome 380.70 9.45 1022 236682 100391 64160637
Toxicity to various agents 329.00 9.45 520 237184 362993 63898035
Fall 322.77 9.45 657 237047 416169 63844859
Polyomavirus-associated nephropathy 321.39 9.45 209 237495 4679 64256349
Cytomegalovirus viraemia 301.65 9.45 278 237426 10550 64250478
Drug abuse 300.41 9.45 61 237643 132313 64128715
Respiratory failure 296.90 9.45 1279 236425 159904 64101124
Cytomegalovirus infection reactivation 292.71 9.45 210 237494 5546 64255482
Epstein-Barr virus infection 277.15 9.45 283 237421 12205 64248823
Blood pressure fluctuation 276.65 9.45 599 237105 51272 64209756
Post transplant lymphoproliferative disorder 275.56 9.45 250 237454 9294 64251734
Thrombotic microangiopathy 260.06 9.45 314 237390 16341 64244687
Haemophagocytic lymphohistiocytosis 258.80 9.45 322 237382 17287 64243741
BK virus infection 258.04 9.45 216 237488 7196 64253832
Graft versus host disease 248.36 9.45 280 237424 13533 64247495
Complications of transplanted kidney 246.36 9.45 185 237519 5250 64255778
Graft versus host disease in gastrointestinal tract 238.90 9.45 184 237520 5428 64255600
Strongyloidiasis 237.88 9.45 146 237558 2944 64258084
Product dose omission issue 234.57 9.45 223 237481 194524 64066504
Pseudomonas infection 229.85 9.45 306 237398 17577 64243451
Enterococcal infection 227.32 9.45 268 237436 13598 64247430
Klebsiella infection 226.58 9.45 262 237442 13019 64248009
Nocardiosis 224.43 9.45 166 237538 4601 64256427
Adenovirus infection 211.34 9.45 191 237513 7064 64253964
Septic shock 209.88 9.45 857 236847 104580 64156448
Blood pressure diastolic abnormal 206.51 9.45 237 237467 11680 64249348
Urine abnormality 193.49 9.45 183 237521 7179 64253849
Lymphocyte count decreased 189.11 9.45 445 237259 40254 64220774
Cardiac failure congestive 188.00 9.45 125 237579 130455 64130573
Steroid diabetes 185.17 9.45 118 237586 2548 64258480
Glossodynia 182.05 9.45 15 237689 64681 64196347
Candida infection 180.43 9.45 374 237330 31045 64229983
Delayed graft function 178.30 9.45 121 237583 2915 64258113
Nausea 177.47 9.45 1948 235756 783852 63477176
Dizziness 175.08 9.45 903 236801 429260 63831768
Intentional overdose 174.29 9.45 57 237647 89887 64171141
Oxygen saturation decreased 172.15 9.45 817 236887 106359 64154669
Blood pressure systolic abnormal 169.38 9.45 196 237508 9746 64251282
Confusional state 169.36 9.45 452 237252 260692 64000336
Fatigue 165.08 9.45 1866 235838 746864 63514164
Progressive multifocal leukoencephalopathy 164.53 9.45 264 237440 17968 64243060
Pneumonia cytomegaloviral 162.64 9.45 132 237572 4207 64256821
Pneumomediastinum 159.50 9.45 111 237593 2789 64258239
Red blood cells urine positive 156.92 9.45 131 237573 4347 64256681
Lymphopenia 153.93 9.45 311 237393 25346 64235682
Injection site pain 153.27 9.45 112 237592 111296 64149732
Cytomegalovirus test positive 150.97 9.45 136 237568 5008 64256020
Graft versus host disease in skin 148.39 9.45 137 237567 5210 64255818
Overdose 146.22 9.45 226 237478 159340 64101688
Human herpesvirus 6 infection 144.44 9.45 127 237577 4527 64256501
Vomiting 144.19 9.45 1318 236386 549799 63711229
Cystitis haemorrhagic 142.56 9.45 161 237543 7795 64253233
Blood pressure increased 141.93 9.45 1105 236599 171447 64089581
Dehydration 141.40 9.45 374 237330 216389 64044639
Pneumatosis intestinalis 141.29 9.45 132 237572 5097 64255931
Varicella zoster virus infection 134.71 9.45 113 237591 3775 64257253
Cytomegalovirus colitis 133.70 9.45 113 237591 3815 64257213
Synovitis 131.97 9.45 103 237601 98987 64162041
Liver transplant rejection 131.32 9.45 100 237604 2899 64258129
Contraindicated product administered 130.31 9.45 123 237581 107706 64153322
Myocardial infarction 130.04 9.45 259 237445 165562 64095466
Acinetobacter infection 129.00 9.45 91 237613 2338 64258690
Abdominal discomfort 127.11 9.45 304 237400 182018 64079010
Acute graft versus host disease in skin 125.01 9.45 140 237564 6715 64254313
Mycobacterium chelonae infection 122.72 9.45 84 237620 2053 64258975
Cytomegalovirus chorioretinitis 121.33 9.45 118 237586 4794 64256234
White blood cells urine positive 121.00 9.45 123 237581 5275 64255753
Constipation 120.29 9.45 437 237267 228900 64032128
Parvovirus B19 infection 120.23 9.45 68 237636 1171 64259857
Immunosuppressant drug level increased 118.48 9.45 140 237564 7119 64253909
Wrong technique in product usage process 117.65 9.45 46 237658 64928 64196100
Throat irritation 116.96 9.45 324 237380 32387 64228641
Urine leukocyte esterase positive 116.04 9.45 98 237606 3305 64257723
Drug resistance 115.12 9.45 337 237367 34765 64226263
Myopathy 112.91 9.45 220 237484 17460 64243568
Hypoglycaemia 112.82 9.45 99 237605 89793 64171235
Drug intolerance 112.50 9.45 338 237366 187654 64073374
Anti-cyclic citrullinated peptide antibody positive 110 9.45 24 237680 49538 64211490
Escherichia infection 109.62 9.45 199 237505 14969 64246059
Hospitalisation 109.56 9.45 71 237633 75136 64185892
Hand deformity 109.50 9.45 47 237657 62724 64198304
Cerebrovascular accident 109.49 9.45 213 237491 137370 64123658
Syncope 108.94 9.45 264 237440 157371 64103657
Nephropathy toxic 105.90 9.45 213 237491 17301 64243727
Acute respiratory distress syndrome 105.66 9.45 350 237354 38585 64222443
Chorioretinopathy 104.54 9.45 77 237627 2120 64258908
Disease recurrence 102.83 9.45 302 237402 31208 64229820
Pericarditis 102.56 9.45 51 237653 62465 64198563
Swelling 102.51 9.45 279 237425 159939 64101089
Wound 102.45 9.45 79 237625 76398 64184630
Chronic allograft nephropathy 102.36 9.45 66 237638 1455 64259573
Diarrhoea 102.18 9.45 1964 235740 720740 63540288
Urinary sediment present 101.16 9.45 76 237628 2158 64258870
Cushingoid 100.63 9.45 132 237572 7471 64253557
Heart rate decreased 98.19 9.45 433 237271 54634 64206394
Suicide attempt 98.15 9.45 71 237633 70936 64190092
COVID-19 97.67 9.45 487 237217 64653 64196375
Alopecia 97.62 9.45 300 237404 165390 64095638
Duodenal ulcer perforation 97.48 9.45 8 237696 34617 64226411
Acute graft versus host disease 96.68 9.45 142 237562 8942 64252086
Secondary immunodeficiency 96.09 9.45 80 237624 2644 64258384
Disseminated intravascular coagulation 95.22 9.45 299 237405 32049 64228979
Asthenia 94.66 9.45 1065 236639 426979 63834049
Pulmonary mucormycosis 93.79 9.45 50 237654 762 64260266
Serotonin syndrome 93.56 9.45 16 237688 39266 64221762
Pemphigus 93.02 9.45 54 237650 60647 64200381
Renal tubular atrophy 92.33 9.45 62 237642 1467 64259561
Leukopenia 91.44 9.45 663 237041 100579 64160449
Renal transplant failure 90.73 9.45 63 237641 1577 64259451
Crystal urine present 90.42 9.45 67 237637 1862 64259166
Herpes simplex 90.23 9.45 149 237555 10387 64250641
Irritable bowel syndrome 89.49 9.45 15 237689 37354 64223674
Pneumocystis jirovecii infection 88.86 9.45 72 237632 2289 64258739
Focal segmental glomerulosclerosis 88.70 9.45 79 237625 2865 64258163
Enterobacter infection 87.96 9.45 87 237617 3609 64257419
Sepsis 87.66 9.45 1262 236442 229079 64031949
Blood pressure systolic increased 86.01 9.45 386 237318 49067 64211961
Rheumatoid factor positive 85.98 9.45 13 237691 34925 64226103
Rheumatoid arthritis 85.92 9.45 955 236749 163339 64097689
Blood pressure diastolic decreased 85.85 9.45 227 237477 22074 64238954
Discomfort 85.70 9.45 103 237601 80775 64180253
Opportunistic infection 85.34 9.45 74 237630 2588 64258440
Therapy non-responder 84.61 9.45 472 237232 65427 64195601
Injection site erythema 84.08 9.45 82 237622 70718 64190310
Arthropathy 84.03 9.45 202 237502 120765 64140263
Systemic mycosis 83.56 9.45 69 237635 2254 64258774
Decreased appetite 82.63 9.45 652 237052 280637 63980391
Infective aneurysm 82.01 9.45 47 237657 831 64260197
Staphylococcal sepsis 81.75 9.45 160 237544 12739 64248289
COVID-19 pneumonia 81.65 9.45 185 237519 16319 64244709
Proteinuria 81.37 9.45 256 237448 27467 64233561
Acute graft versus host disease in intestine 80.46 9.45 82 237622 3527 64257501
Osteonecrosis 80.41 9.45 258 237446 27971 64233057
Sleep disorder due to general medical condition, insomnia type 80.09 9.45 4 237700 26266 64234762
Rebound effect 78.88 9.45 94 237610 4823 64256205
Necrotising retinitis 78.71 9.45 49 237655 1014 64260014
Diffuse alveolar damage 78.57 9.45 77 237627 3158 64257870
Mycobacterium abscessus infection 78.28 9.45 48 237656 966 64260062
Systemic candida 77.58 9.45 97 237607 5232 64255796
Reversible cerebral vasoconstriction syndrome 76.90 9.45 66 237638 2276 64258752
Rhabdomyolysis 76.49 9.45 138 237566 91588 64169440
Oedema peripheral 75.82 9.45 459 237245 209858 64051170
Protein urine present 75.81 9.45 126 237578 8830 64252198
Ureaplasma infection 75.68 9.45 42 237662 696 64260332
Cytomegalovirus enteritis 75.65 9.45 41 237663 647 64260381
International normalised ratio increased 75.51 9.45 109 237595 79058 64181970
Bacterial test 75.43 9.45 50 237654 1157 64259871
Dyspnoea 75.21 9.45 2046 235658 716628 63544400
Infection reactivation 74.49 9.45 61 237643 1969 64259059
Electric shock 73.55 9.45 48 237656 1081 64259947
Peripheral swelling 73.04 9.45 461 237243 208692 64052336
JC virus infection 72.57 9.45 75 237629 3280 64257748
Disseminated mucormycosis 72.31 9.45 36 237668 472 64260556
Muscle injury 72.02 9.45 7 237697 26430 64234598
Pain 71.83 9.45 1525 236179 551986 63709042
Transplant failure 71.79 9.45 79 237625 3715 64257313
Aplasia 71.57 9.45 107 237597 6846 64254182
Loss of personal independence in daily activities 70.85 9.45 98 237606 72356 64188672
Viraemia 70.70 9.45 63 237641 2286 64258742
Vasculitis 70.48 9.45 185 237519 17910 64243118
Large intestine perforation 69.98 9.45 148 237556 12456 64248572
Intentional product use issue 69.84 9.45 595 237109 94769 64166259
Helicobacter infection 69.71 9.45 27 237677 38335 64222693
Thrombocytopenia 69.47 9.45 1185 236519 222616 64038412
Acute graft versus host disease in liver 68.95 9.45 54 237650 1633 64259395
Product prescribing error 68.93 9.45 22 237682 35247 64225781
Bacterial sepsis 68.68 9.45 109 237595 7348 64253680
Human herpesvirus 8 infection 68.39 9.45 45 237659 1028 64260000
Malaise 68.37 9.45 1038 236666 395209 63865819
Intentional product misuse 67.52 9.45 101 237603 72194 64188834
Hyperglycaemia 67.49 9.45 420 237284 60548 64200480
Pseudomonal sepsis 67.22 9.45 89 237615 5083 64255945
Lung abscess 67.04 9.45 74 237630 3492 64257536
Urine ketone body present 66.32 9.45 71 237633 3236 64257792
Diabetes mellitus 66.28 9.45 446 237258 66028 64195000
Sedation 66.25 9.45 35 237669 41427 64219601
Fungal infection 66.19 9.45 276 237428 33975 64227053
Granulomatosis with polyangiitis 66.09 9.45 58 237646 2062 64258966
Intensive care unit acquired weakness 65.70 9.45 53 237651 1674 64259354
Lupus nephritis 65.13 9.45 61 237643 2363 64258665
Coronary artery disease 65.05 9.45 76 237628 60357 64200671
Epstein-Barr virus associated lymphoproliferative disorder 64.38 9.45 68 237636 3051 64257977
Glomerulonephritis 64.32 9.45 66 237638 2862 64258166
Hyponatraemia 63.82 9.45 305 237399 148034 64112994
Diffuse large B-cell lymphoma 62.63 9.45 126 237578 10235 64250793
Premature delivery 62.42 9.45 180 237524 18409 64242619
Accidental exposure to product 62.21 9.45 11 237693 26353 64234675
Adverse event 62.12 9.45 34 237670 39455 64221573
Device expulsion 62.03 9.45 4 237700 21132 64239896
Immunosuppressant drug level decreased 61.33 9.45 52 237652 1763 64259265
Urine analysis abnormal 61.29 9.45 90 237614 5666 64255362
Mycoplasma infection 60.27 9.45 35 237669 635 64260393
Pyrexia 60.00 9.45 2573 235131 556071 63704957
Kidney fibrosis 59.42 9.45 65 237639 3036 64257992
Orthostatic hypotension 59.21 9.45 51 237653 46687 64214341
Pathogen resistance 59.18 9.45 138 237566 12405 64248623
Symptom masked 59.10 9.45 43 237661 1161 64259867
Intervertebral discitis 59.03 9.45 72 237632 3785 64257243
Cytomegalovirus enterocolitis 58.93 9.45 45 237659 1310 64259718
Accidental overdose 58.72 9.45 25 237679 33532 64227496
Listeriosis 57.64 9.45 52 237652 1918 64259110
Viral haemorrhagic cystitis 57.64 9.45 48 237656 1587 64259441
Pulmonary alveolar haemorrhage 57.17 9.45 117 237587 9621 64251407
Temperature regulation disorder 57.11 9.45 74 237630 4137 64256891
Neutrophil percentage increased 57.02 9.45 76 237628 4369 64256659
Cryptococcosis 56.75 9.45 60 237644 2695 64258333
Heart rate increased 56.39 9.45 584 237120 98091 64162937
Bacterial infection 56.24 9.45 211 237493 24739 64236289
Injection site bruising 56.23 9.45 32 237672 36341 64224687
Atrial fibrillation 55.73 9.45 385 237319 170704 64090324
Pneumonia pseudomonal 55.62 9.45 79 237625 4824 64256204
Glomerulosclerosis 55.58 9.45 38 237666 927 64260101
C-reactive protein abnormal 55.22 9.45 19 237685 29028 64232000
Central nervous system infection 54.91 9.45 41 237663 1153 64259875
Drug effective for unapproved indication 54.79 9.45 68 237636 3640 64257388
Immune thrombocytopenia 54.62 9.45 150 237554 14916 64246112
Systemic lupus erythematosus 54.36 9.45 129 237575 77483 64183545
Lymphocyte percentage decreased 54.36 9.45 76 237628 4573 64256455
Product quality issue 54.10 9.45 21 237683 29778 64231250
Chronic graft versus host disease 54.07 9.45 89 237615 6187 64254841
Contusion 54.03 9.45 226 237478 113739 64147289
Graft versus host disease in liver 53.83 9.45 45 237659 1496 64259532
Pneumonia cryptococcal 53.56 9.45 41 237663 1198 64259830
Blood urine present 53.49 9.45 169 237535 18171 64242857
Culture urine positive 53.29 9.45 71 237633 4080 64256948
Depressed level of consciousness 52.66 9.45 141 237563 81295 64179733
Haemoglobin urine present 52.12 9.45 35 237669 828 64260200
Herpes zoster 51.76 9.45 482 237222 78705 64182323
Inappropriate schedule of product administration 51.59 9.45 171 237533 92115 64168913
Stomatitis 51.56 9.45 218 237486 109387 64151641
Lethargy 51.37 9.45 120 237584 72474 64188554
Pulmonary nocardiosis 51.24 9.45 33 237671 726 64260302
Staphylococcal infection 51.10 9.45 341 237363 50337 64210691
Demyelination 51.09 9.45 91 237613 6743 64254285
Penicillium infection 50.67 9.45 22 237682 206 64260822
Neutrophil count increased 50.33 9.45 205 237499 24969 64236059
Adverse drug reaction 50.21 9.45 56 237648 45408 64215620
Injection site swelling 50.14 9.45 47 237657 41306 64219722
Dural arteriovenous fistula 50.04 9.45 15 237689 39 64260989
Injection site reaction 49.88 9.45 59 237645 46605 64214423
Poisoning 49.77 9.45 10 237694 21869 64239159
Erythema 49.76 9.45 967 236737 186103 64074925
Phaeohyphomycosis 49.66 9.45 37 237667 1037 64259991
Respiratory arrest 49.50 9.45 74 237630 52911 64208117
Disseminated tuberculosis 49.35 9.45 64 237640 3581 64257447
Fusarium infection 49.06 9.45 43 237661 1526 64259502
Tuberculosis 48.45 9.45 131 237573 12907 64248121
Blood pressure diastolic increased 48.24 9.45 116 237588 10636 64250392
Neuroleptic malignant syndrome 48.12 9.45 16 237688 24980 64236048
Herpes virus infection 47.78 9.45 84 237620 6160 64254868
Hypertension 47.65 9.45 1272 236432 257989 64003039
Renal tubular necrosis 47.38 9.45 184 237520 21926 64239102
Device malfunction 47.17 9.45 5 237699 17628 64243400
Folliculitis 47.16 9.45 26 237678 30051 64230977
Red cell distribution width increased 47.08 9.45 125 237579 12184 64248844
Feeling abnormal 46.86 9.45 294 237410 133308 64127720
Pneumonia acinetobacter 46.83 9.45 18 237686 119 64260909
Osteomyelitis fungal 46.72 9.45 22 237682 253 64260775
Pneumonia fungal 46.71 9.45 102 237602 8775 64252253
Stenotrophomonas infection 46.34 9.45 57 237647 3023 64258005
Hypogammaglobulinaemia 46.08 9.45 111 237593 10188 64250840
Chest pain 46.01 9.45 603 237101 235377 64025651
Bacteraemia 46.00 9.45 209 237495 26702 64234326
Epstein-Barr viraemia 45.95 9.45 44 237660 1753 64259275
Unresponsive to stimuli 45.52 9.45 72 237632 50321 64210707
Encephalitis cytomegalovirus 45.08 9.45 34 237670 971 64260057
Perinephric abscess 44.92 9.45 20 237684 200 64260828
Febrile bone marrow aplasia 44.79 9.45 116 237588 11139 64249889
Gastroenteritis norovirus 44.43 9.45 53 237651 2722 64258306
Loss of consciousness 44.39 9.45 342 237362 148023 64113005
Cerebral aspergillosis 44.33 9.45 42 237662 1651 64259377
Pneumothorax 44.01 9.45 192 237512 24106 64236922
Mobility decreased 44.00 9.45 165 237539 85675 64175353
Transient ischaemic attack 43.96 9.45 59 237645 44123 64216905
Immunodeficiency 43.79 9.45 145 237559 15979 64245049
Steroid dependence 43.39 9.45 24 237680 395 64260633
Pain in extremity 43.11 9.45 822 236882 302263 63958765
Incision site pain 43.01 9.45 51 237653 2603 64258425
Ear pruritus 42.91 9.45 51 237653 2609 64258419
Cytomegalovirus oesophagitis 42.37 9.45 27 237677 583 64260445
Ureteric stenosis 42.23 9.45 36 237668 1230 64259798
Acute kidney injury 41.78 9.45 1299 236405 447941 63813087
Pharyngeal paraesthesia 41.73 9.45 43 237661 1874 64259154
Nephrotic syndrome 41.62 9.45 102 237602 9465 64251563
Encephalitis 41.50 9.45 121 237583 12450 64248578
Knee arthroplasty 41.38 9.45 24 237680 26975 64234053
Peritonitis 41.04 9.45 192 237512 24831 64236197
Swollen tongue 40.90 9.45 41 237663 34913 64226115
B-lymphocyte count decreased 40.75 9.45 34 237670 1127 64259901
Epstein-Barr virus infection reactivation 40.63 9.45 34 237670 1132 64259896
Hallucination 40.59 9.45 135 237569 72653 64188375
Abdominal infection 40.40 9.45 52 237652 2888 64258140
Hypophagia 40.27 9.45 52 237652 39535 64221493
Haemolytic uraemic syndrome 40.14 9.45 61 237643 3960 64257068
Fungaemia 40.04 9.45 59 237645 3726 64257302
Brain abscess 39.73 9.45 62 237642 4119 64256909
Corynebacterium infection 39.45 9.45 31 237673 942 64260086
Intentional self-injury 38.89 9.45 30 237674 29014 64232014
Cytomegalovirus gastrointestinal infection 38.86 9.45 23 237681 433 64260595
Gastroenteritis rotavirus 38.84 9.45 22 237682 380 64260648
Malignant neoplasm progression 38.74 9.45 250 237454 112621 64148407
Drug interaction 38.70 9.45 1027 236677 361056 63899972
Amoebic colitis 38.58 9.45 14 237690 77 64260951
Graft loss 38.51 9.45 31 237673 976 64260052
Epstein-Barr virus associated lymphoma 38.43 9.45 30 237674 903 64260125
Pulmonary haemorrhage 38.42 9.45 121 237583 12988 64248040
Full blood count abnormal 38.27 9.45 32 237672 29725 64231303
Cardio-respiratory arrest 37.96 9.45 210 237494 98183 64162845
Coma 37.75 9.45 180 237524 87435 64173593
Therapeutic product effect decreased 37.34 9.45 260 237444 115091 64145937
Kaposi's sarcoma 37.33 9.45 27 237677 722 64260306
Escherichia sepsis 37.33 9.45 82 237622 7083 64253945
Aggression 37.25 9.45 71 237633 46161 64214867
Injection site pruritus 37.14 9.45 51 237653 37775 64223253
Multiple-drug resistance 36.85 9.45 77 237627 6425 64254603
Fungal skin infection 36.73 9.45 67 237637 5058 64255970
West Nile viral infection 36.72 9.45 29 237675 888 64260140
Adrenal insufficiency 36.48 9.45 172 237532 22315 64238713
Leukocytosis 36.29 9.45 251 237453 37489 64223539
Human polyomavirus infection 36.10 9.45 30 237674 989 64260039
Pleocytosis 35.95 9.45 31 237673 1076 64259952
Dyskinesia 35.84 9.45 56 237648 39332 64221696
Pancytopenia 35.49 9.45 733 236971 142576 64118452
Bacterial test positive 35.35 9.45 77 237627 6613 64254415
Cytomegalovirus hepatitis 35.19 9.45 24 237680 583 64260445
Miosis 34.88 9.45 4 237700 13262 64247766
IgA nephropathy 34.58 9.45 34 237670 1400 64259628
Disseminated varicella zoster vaccine virus infection 34.48 9.45 14 237690 109 64260919
Pedal pulse abnormal 34.22 9.45 15 237689 144 64260884
Oral herpes 34.17 9.45 167 237537 21985 64239043
Cardiac arrest 34.07 9.45 383 237321 153681 64107347
Haemolytic anaemia 33.91 9.45 133 237571 15920 64245108
Disseminated cryptococcosis 33.84 9.45 35 237669 1532 64259496
Cutaneous mucormycosis 33.73 9.45 14 237690 116 64260912
Clostridium difficile colitis 33.62 9.45 193 237511 27030 64233998
Cardiac disorder 33.60 9.45 100 237604 55716 64205312
Psoriatic arthropathy 33.55 9.45 68 237636 43213 64217815
Plasma cell myeloma 33.54 9.45 75 237629 46000 64215028
Blister 33.35 9.45 169 237535 80798 64180230
Obliterative bronchiolitis 33.32 9.45 45 237659 2620 64258408
Cryptococcal meningoencephalitis 33.09 9.45 16 237688 196 64260832
Incorrect dose administered 33.00 9.45 114 237590 60651 64200377
Segmental diverticular colitis 32.82 9.45 14 237690 125 64260903
Polyomavirus viraemia 32.68 9.45 30 237674 1132 64259896
Tremor 32.58 9.45 369 237335 147861 64113167
Bone pain 32.57 9.45 80 237624 47492 64213536
Disseminated strongyloidiasis 32.49 9.45 13 237691 97 64260931
Aplastic anaemia 32.44 9.45 119 237585 13801 64247227
Rhinocerebral mucormycosis 32.37 9.45 21 237683 468 64260560
Treatment noncompliance 32.29 9.45 70 237634 43412 64217616
Shock haemorrhagic 32.20 9.45 135 237569 16656 64244372
Quadriplegia 31.92 9.45 47 237657 2966 64258062
Torsade de pointes 31.91 9.45 12 237692 17351 64243677
Monocyte count increased 31.87 9.45 83 237621 7996 64253032
Specific gravity urine decreased 31.87 9.45 25 237679 758 64260270
Encephalitis autoimmune 31.85 9.45 37 237667 1847 64259181
Anxiety 31.82 9.45 540 237164 202109 64058919
Sleep disorder 31.76 9.45 113 237591 59596 64201432
Cerebral venous thrombosis 31.72 9.45 42 237662 2399 64258629
Steroid withdrawal syndrome 31.42 9.45 23 237681 627 64260401
Multiple sclerosis relapse 31.34 9.45 259 237445 40876 64220152
Pneumoperitoneum 31.22 9.45 44 237660 2667 64258361
Laryngeal stenosis 31.20 9.45 25 237679 782 64260246
Parvovirus infection 30.96 9.45 22 237682 572 64260456
Blood potassium increased 30.94 9.45 30 237674 25950 64235078
Necrotising herpetic retinopathy 30.88 9.45 13 237691 112 64260916
Blood glucose decreased 30.81 9.45 24 237680 23099 64237929
Intra-abdominal pressure increased 30.78 9.45 16 237688 231 64260797
C-reactive protein increased 30.66 9.45 506 237198 94403 64166625
Urinary tract infection bacterial 30.62 9.45 62 237642 5059 64255969
Osteoporosis 30.50 9.45 262 237442 41818 64219210
Hepatic artery thrombosis 30.41 9.45 17 237687 286 64260742
Central nervous system fungal infection 30.11 9.45 19 237685 403 64260625
Alveolitis 30.00 9.45 51 237653 3641 64257387
Serum sickness 29.90 9.45 47 237657 3142 64257886
Therapy cessation 29.74 9.45 46 237658 32443 64228585
Blood thyroid stimulating hormone decreased 29.72 9.45 62 237642 5168 64255860
Transplant dysfunction 29.69 9.45 72 237632 6636 64254392
Reticulocytosis 29.53 9.45 20 237684 480 64260548
Enterococcus test positive 29.53 9.45 34 237670 1681 64259347
Apoptosis 29.44 9.45 17 237687 305 64260723
Human bocavirus infection 29.42 9.45 21 237683 550 64260478
Therapeutic response decreased 29.39 9.45 308 237396 51880 64209148
Full blood count decreased 29.39 9.45 24 237680 22558 64238470
Unevaluable event 29.29 9.45 92 237612 50397 64210631
Food allergy 29.29 9.45 79 237625 7772 64253256
Intestinal perforation 29.27 9.45 123 237581 15190 64245838
Oesophageal candidiasis 29.24 9.45 80 237624 7937 64253091
Substance-induced psychotic disorder 29.22 9.45 43 237661 2712 64258316
Pneumonia klebsiella 29.21 9.45 53 237651 3984 64257044
Thunderclap headache 29.20 9.45 15 237689 211 64260817
Extrapyramidal disorder 29.10 9.45 18 237686 19534 64241494
Nightmare 28.99 9.45 21 237683 20972 64240056
Injection site haemorrhage 28.95 9.45 28 237676 24250 64236778
Post-traumatic stress disorder 28.91 9.45 54 237650 4151 64256877
Nitrite urine present 28.84 9.45 27 237677 1045 64259983
Red blood cell sedimentation rate abnormal 28.77 9.45 12 237692 16294 64244734
Somnolence 28.71 9.45 553 237151 203092 64057936
Muscle spasms 28.71 9.45 357 237347 140666 64120362
Band sensation 28.62 9.45 22 237682 647 64260381
Gastrooesophageal reflux disease 28.61 9.45 184 237520 82959 64178069
Blood beta-D-glucan increased 28.55 9.45 20 237684 508 64260520
Intestine transplant rejection 28.46 9.45 11 237693 74 64260954
Psoriasis 28.22 9.45 152 237552 71551 64189477
Abscess bacterial 28.20 9.45 23 237681 738 64260290
Scopulariopsis infection 28.15 9.45 12 237692 107 64260921
Myalgia 28.14 9.45 413 237291 158204 64102824
Gastrointestinal mucormycosis 28.04 9.45 17 237687 335 64260693
Hepatitis B 27.96 9.45 77 237627 7668 64253360
Monocytopenia 27.96 9.45 13 237691 145 64260883
Suicidal ideation 27.91 9.45 138 237566 66404 64194624
Pseudomonal bacteraemia 27.89 9.45 38 237666 2231 64258797
Lower respiratory tract infection 27.87 9.45 219 237485 94395 64166633
Infective pulmonary exacerbation of cystic fibrosis 27.66 9.45 5 237699 11791 64249237
Pulmonary hypertension 27.65 9.45 75 237629 43064 64217964
Aplasia pure red cell 27.61 9.45 72 237632 6942 64254086
Gait disturbance 27.59 9.45 457 237247 171698 64089330
Sedation complication 27.53 9.45 3 237701 10351 64250677
Skin striae 27.45 9.45 30 237674 1400 64259628
Respiratory rate increased 27.43 9.45 137 237567 18194 64242834
Hip arthroplasty 27.40 9.45 23 237681 21328 64239700
Herpes simplex viraemia 27.38 9.45 15 237689 242 64260786
Lymphocele 27.36 9.45 32 237672 1609 64259419
Proteus infection 27.33 9.45 32 237672 1611 64259417
Dystonia 27.21 9.45 18 237686 18847 64242181
Product substitution issue 27.20 9.45 16 237688 17845 64243183
Device issue 27.15 9.45 26 237678 22622 64238406
Arrhythmia 26.98 9.45 102 237602 52842 64208186
Injection site mass 26.97 9.45 15 237689 17255 64243773
Angina pectoris 26.97 9.45 81 237623 45000 64216028
Device dislocation 26.95 9.45 23 237681 21155 64239873
Stress 26.88 9.45 123 237581 60411 64200617
Immunosuppression 26.86 9.45 94 237610 10652 64250376
Graft complication 26.82 9.45 21 237683 635 64260393
Acute myocardial infarction 26.78 9.45 149 237555 69569 64191459
Rectal haemorrhage 26.63 9.45 127 237577 61690 64199338
Smear cervix abnormal 26.56 9.45 38 237666 2336 64258692
Multiple sclerosis 26.55 9.45 139 237565 18802 64242226
Malacoplakia gastrointestinal 26.48 9.45 13 237691 165 64260863
General physical health deterioration 26.46 9.45 563 237141 203862 64057166
Wheezing 26.38 9.45 181 237523 80398 64180630
Haemodynamic instability 26.37 9.45 117 237587 14795 64246233
American trypanosomiasis 26.27 9.45 16 237688 318 64260710
Obstructive airways disorder 26.21 9.45 28 237676 23157 64237871
Drug withdrawal syndrome 26.14 9.45 47 237657 31244 64229784
Pulmonary tuberculosis 26.13 9.45 72 237632 7172 64253856
Lymphoproliferative disorder 26.13 9.45 58 237646 5045 64255983
Renal impairment 26.09 9.45 667 237037 134350 64126678
Meningoencephalitis viral 26.08 9.45 17 237687 382 64260646
Thymus hypoplasia 26.08 9.45 19 237685 514 64260514
Systemic inflammatory response syndrome 25.99 9.45 90 237614 10145 64250883
Pneumonia bacterial 25.87 9.45 117 237587 14918 64246110
Hepatic failure 25.80 9.45 315 237389 55079 64205949
Partial seizures 25.74 9.45 72 237632 7235 64253793
Renal graft infection 25.55 9.45 17 237687 396 64260632
Cardiac failure 25.50 9.45 339 237365 132034 64128994
Candida sepsis 25.42 9.45 36 237668 2192 64258836
Visceral leishmaniasis 25.34 9.45 24 237680 943 64260085
Quadriparesis 25.27 9.45 41 237663 2816 64258212
Trichodysplasia spinulosa 25.20 9.45 21 237683 695 64260333
Abnormal dreams 25.15 9.45 4 237700 10352 64250676
Coeliac disease 25.10 9.45 72 237632 7340 64253688
Status epilepticus 25.08 9.45 151 237553 21512 64239516
Necrosis ischaemic 25.00 9.45 24 237680 959 64260069
Hypoalbuminaemia 24.98 9.45 130 237574 17544 64243484
Pyelonephritis fungal 24.97 9.45 11 237693 107 64260921
Klebsiella sepsis 24.97 9.45 39 237665 2593 64258435
Haematemesis 24.96 9.45 89 237615 46910 64214118
Flushing 24.92 9.45 418 237286 78230 64182798
Feeding intolerance 24.88 9.45 19 237685 553 64260475
Escherichia urinary tract infection 24.84 9.45 99 237605 11938 64249090
Product storage error 24.82 9.45 9 237695 13309 64247719
Tuberculosis gastrointestinal 24.74 9.45 18 237686 486 64260542
Central nervous system lymphoma 24.69 9.45 33 237671 1902 64259126
Neuropsychiatric lupus 24.68 9.45 12 237692 149 64260879
Complications of transplant surgery 24.62 9.45 21 237683 718 64260310
Aspergillosis oral 24.58 9.45 9 237695 51 64260977
Blood calcium decreased 24.54 9.45 35 237669 25519 64235509
Hyperkalaemia 24.54 9.45 246 237458 100883 64160145
Product dispensing error 24.50 9.45 6 237698 11444 64249584
Immune reconstitution inflammatory syndrome 24.49 9.45 101 237603 12369 64248659
Dermatomyositis 24.45 9.45 40 237664 2766 64258262
Bacillus infection 24.45 9.45 21 237683 725 64260303
Factor XIII deficiency 24.39 9.45 10 237694 80 64260948
Palmar-plantar erythrodysaesthesia syndrome 24.34 9.45 43 237661 28776 64232252
Hepatic cirrhosis 24.30 9.45 37 237667 26261 64234767
Toxoplasmosis 24.29 9.45 37 237667 2407 64258621
Endocarditis 24.28 9.45 83 237621 9295 64251733
Mycobacterial infection 23.91 9.45 41 237663 2947 64258081
Autoimmune thyroiditis 23.87 9.45 45 237659 3483 64257545
Inflammatory marker increased 23.85 9.45 77 237627 8374 64252654
Electrocardiogram QRS complex prolonged 23.78 9.45 3 237701 9241 64251787
Pyelonephritis 23.72 9.45 126 237578 17140 64243888
Calcium ionised decreased 23.69 9.45 18 237686 520 64260508
Rash 23.67 9.45 1416 236288 457133 63803895
Adenoviral hepatitis 23.62 9.45 17 237687 451 64260577
Product use issue 23.57 9.45 405 237299 151310 64109718
Memory impairment 23.56 9.45 202 237502 85480 64175548
Microsporidia infection 23.52 9.45 21 237683 764 64260264
Rubella antibody positive 23.35 9.45 9 237695 60 64260968
Autoimmune hepatitis 23.32 9.45 86 237618 9998 64251030
Blood brain barrier defect 23.32 9.45 11 237693 127 64260901
Klebsiella test positive 23.32 9.45 27 237677 1343 64259685
Blood loss anaemia 23.29 9.45 11 237693 13881 64247147
Urobilinogen urine increased 23.21 9.45 19 237685 613 64260415
Hypersensitivity 23.16 9.45 549 237155 195903 64065125
Gastrointestinal disorder 23.13 9.45 215 237489 89494 64171534
Blood immunoglobulin M decreased 23.11 9.45 23 237681 961 64260067
Abdominal abscess 23.08 9.45 63 237641 6241 64254787
Intestinal ischaemia 23.05 9.45 94 237610 11455 64249573
Angiocentric lymphoma 23.02 9.45 21 237683 786 64260242
Sideroblastic anaemia 22.98 9.45 13 237691 224 64260804
Leukoencephalopathy 22.94 9.45 67 237637 6900 64254128
Splenic embolism 22.92 9.45 12 237692 176 64260852
Lymphoid tissue hypoplasia 22.89 9.45 17 237687 474 64260554
Angiosarcoma 22.82 9.45 16 237688 407 64260621
Morganella infection 22.69 9.45 23 237681 983 64260045
Toxic epidermal necrolysis 22.68 9.45 223 237481 36943 64224085
Atypical mycobacterial pneumonia 22.66 9.45 11 237693 136 64260892
Capillaritis 22.63 9.45 13 237691 231 64260797
Respiratory depression 22.62 9.45 32 237672 23411 64237617
Oliguria 22.57 9.45 110 237594 14466 64246562
Malacoplakia vesicae 22.51 9.45 9 237695 67 64260961
Multi-organ disorder 22.46 9.45 34 237670 2199 64258829
Labelled drug-drug interaction medication error 22.42 9.45 29 237675 22033 64238995
Bradycardia 22.31 9.45 304 237400 117915 64143113
Lung transplant rejection 22.25 9.45 26 237678 1306 64259722
Osmotic demyelination syndrome 22.20 9.45 25 237679 1206 64259822
Eosinopenia 22.20 9.45 8 237696 43 64260985
Bronchopneumopathy 22.14 9.45 18 237686 575 64260453
Restlessness 22.03 9.45 74 237630 39711 64221317
Abscess 21.99 9.45 134 237570 19170 64241858
Sputum discoloured 21.99 9.45 20 237684 17836 64243192
Neuromyelitis optica spectrum disorder 21.94 9.45 21 237683 836 64260192
Q fever 21.88 9.45 12 237692 194 64260834
Polychondritis 21.86 9.45 16 237688 436 64260592
Pain in jaw 21.76 9.45 77 237627 40678 64220350
Herpes simplex colitis 21.70 9.45 7 237697 25 64261003
Kidney rupture 21.62 9.45 12 237692 199 64260829
Cytokine release syndrome 21.51 9.45 141 237563 20688 64240340
Pyomyositis 21.46 9.45 17 237687 523 64260505
Marrow hyperplasia 21.45 9.45 26 237678 1358 64259670
Lip pruritus 21.40 9.45 19 237685 686 64260342
Heart transplant rejection 21.30 9.45 25 237679 1262 64259766
Device difficult to use 21.23 9.45 5 237699 9793 64251235
Cataract 21.12 9.45 285 237419 50977 64210051
Parainfluenzae virus infection 21.09 9.45 51 237653 4692 64256336
Right ventricular failure 21.03 9.45 29 237675 21442 64239586
Coronavirus infection 20.99 9.45 56 237648 5474 64255554
Atypical mycobacterial infection 20.97 9.45 25 237679 1283 64259745
Anti-thyroid antibody positive 20.95 9.45 16 237688 466 64260562
Histoplasmosis disseminated 20.93 9.45 31 237673 1967 64259061
Blindness 20.91 9.45 146 237558 21873 64239155
Diaphragmatic injury 20.86 9.45 10 237694 120 64260908
Antineutrophil cytoplasmic antibody positive 20.77 9.45 22 237682 990 64260038
Acute respiratory failure 20.73 9.45 278 237426 49656 64211372
Leishmaniasis 20.71 9.45 14 237690 335 64260693
Peliosis hepatis 20.66 9.45 9 237695 85 64260943
Blood creatinine decreased 20.59 9.45 65 237639 6985 64254043
Pneumoretroperitoneum 20.57 9.45 9 237695 86 64260942
Red blood cells urine 20.53 9.45 18 237686 639 64260389
Device leakage 20.51 9.45 3 237701 8263 64252765
Cerebral artery stenosis 20.48 9.45 18 237686 641 64260387
Ultrasound ovary abnormal 20.48 9.45 9 237695 87 64260941
Urinary tract candidiasis 20.44 9.45 18 237686 643 64260385
Aphthous ulcer 20.41 9.45 98 237606 12808 64248220
Sleep disorder due to a general medical condition 20.41 9.45 3 237701 8231 64252797
Pulmonary arterial hypertension 20.40 9.45 39 237665 25328 64235700
Head injury 20.38 9.45 58 237646 32784 64228244
Device related sepsis 20.38 9.45 53 237651 5102 64255926
Meningitis fungal 20.33 9.45 11 237693 173 64260855
CSF measles antibody positive 20.31 9.45 8 237696 57 64260971
Disseminated aspergillosis 20.27 9.45 18 237686 650 64260378
Central nervous system lesion 20.23 9.45 92 237612 11757 64249271
Electrocardiogram QT prolonged 20.22 9.45 191 237513 79257 64181771
Mental status changes 20.21 9.45 137 237567 61025 64200003
Agitation 20.19 9.45 218 237486 88149 64172879
Medication error 20.17 9.45 105 237599 49861 64211167
Adenoviral haemorrhagic cystitis 20.12 9.45 16 237688 495 64260533
Central nervous system vasculitis 20.08 9.45 23 237681 1131 64259897
Gastropleural fistula 19.96 9.45 8 237696 60 64260968
Pneumocephalus 19.95 9.45 12 237692 233 64260795
Pancreas transplant rejection 19.91 9.45 13 237691 293 64260735
Herpes simplex hepatitis 19.84 9.45 15 237689 430 64260598
Post procedural bile leak 19.83 9.45 14 237690 360 64260668
Listeria encephalitis 19.79 9.45 13 237691 296 64260732
Natural killer-cell leukaemia 19.79 9.45 9 237695 95 64260933
Herpes zoster meningoencephalitis 19.77 9.45 18 237686 672 64260356
Underdose 19.66 9.45 41 237663 25788 64235240
Bronchopleural fistula 19.64 9.45 17 237687 593 64260435
Birdshot chorioretinopathy 19.62 9.45 8 237696 63 64260965
Serratia infection 19.61 9.45 26 237678 1487 64259541
Arteriosclerosis coronary artery 19.60 9.45 17 237687 15512 64245516
Monocyte percentage increased 19.48 9.45 30 237674 1970 64259058
Akathisia 19.47 9.45 9 237695 11501 64249527
Post procedural urine leak 19.44 9.45 10 237694 141 64260887
Respiratory tract infection fungal 19.40 9.45 22 237682 1070 64259958
Central nervous system viral infection 19.39 9.45 9 237695 100 64260928
Listeria sepsis 19.38 9.45 17 237687 604 64260424
Enteritis 19.32 9.45 92 237612 11985 64249043
Mixed liver injury 19.30 9.45 54 237650 5427 64255601
Leukocyturia 19.27 9.45 26 237678 1512 64259516
Cytomegalovirus nephritis 19.26 9.45 10 237694 144 64260884
Transaminases increased 19.23 9.45 250 237454 44344 64216684
Injection site warmth 19.21 9.45 13 237691 13449 64247579
Herpes simplex oesophagitis 19.21 9.45 12 237692 250 64260778
CSF protein increased 19.18 9.45 22 237682 1083 64259945
Blood immunoglobulin G decreased 19.13 9.45 35 237669 2648 64258380
Tubulointerstitial nephritis 19.12 9.45 186 237518 30723 64230305
Porphyria acute 19.12 9.45 18 237686 702 64260326
Blindness cortical 19.09 9.45 19 237685 794 64260234
Biloma 19.08 9.45 10 237694 147 64260881
Mean cell haemoglobin decreased 19.06 9.45 45 237659 4077 64256951
Fear 19.00 9.45 28 237676 20143 64240885
Bordetella infection 19 9.45 9 237695 105 64260923
Condition aggravated 18.93 9.45 1606 236098 370820 63890208
Herpes simplex encephalitis 18.91 9.45 17 237687 624 64260404
Poikiloderma 18.84 9.45 13 237691 322 64260706
Thrombosis 18.77 9.45 168 237536 70474 64190554
Cerebral fungal infection 18.70 9.45 13 237691 326 64260702
Bifidobacterium infection 18.70 9.45 6 237698 21 64261007
Gonococcal infection 18.65 9.45 7 237697 43 64260985
Oedema 18.60 9.45 233 237471 91702 64169326
Hepatic necrosis 18.55 9.45 71 237633 8402 64252626
Scedosporium infection 18.53 9.45 23 237681 1231 64259797
Feeling hot 18.46 9.45 253 237451 45410 64215618
Complication associated with device 18.44 9.45 17 237687 15063 64245965
Haemoperitoneum 18.39 9.45 43 237661 3872 64257156
Arterial rupture 18.33 9.45 18 237686 740 64260288
Creatinine urine increased 18.26 9.45 14 237690 410 64260618
Osteonecrosis of jaw 18.23 9.45 80 237624 39745 64221283
Interleukin level increased 18.20 9.45 14 237690 412 64260616
Prostate cancer 18.14 9.45 28 237676 19767 64241261
Bradyphrenia 18.14 9.45 6 237698 9400 64251628
Staphylococcal bacteraemia 18.13 9.45 81 237623 10274 64250754
Myocarditis infectious 18.12 9.45 7 237697 47 64260981
Urine oxalate increased 18.04 9.45 11 237693 219 64260809
Pericarditis fungal 17.95 9.45 10 237694 167 64260861
Irritability 17.95 9.45 72 237632 36674 64224354
Neurological decompensation 17.94 9.45 46 237658 4390 64256638
Muir-Torre syndrome 17.87 9.45 7 237697 49 64260979
Therapeutic product effect incomplete 17.81 9.45 271 237433 103211 64157817
Serum ferritin increased 17.76 9.45 70 237634 8398 64252630
Hemianopia 17.76 9.45 25 237679 1514 64259514
Red blood cell count increased 17.75 9.45 40 237664 3515 64257513
Subcapsular renal haematoma 17.74 9.45 17 237687 678 64260350
Acute disseminated encephalomyelitis 17.72 9.45 12 237692 288 64260740
Haemoglobin urine 17.68 9.45 9 237695 124 64260904
Uraemic encephalopathy 17.66 9.45 15 237689 510 64260518
Specific gravity urine increased 17.63 9.45 14 237690 432 64260596
Toxic neuropathy 17.59 9.45 18 237686 778 64260250
Cutaneous nocardiosis 17.54 9.45 10 237694 175 64260853
Lichen sclerosus 17.53 9.45 19 237685 878 64260150
Bone marrow failure 17.51 9.45 261 237443 47691 64213337
Dizziness postural 17.49 9.45 7 237697 9745 64251283
Meningitis cryptococcal 17.48 9.45 36 237668 2973 64258055
Engraftment syndrome 17.40 9.45 21 237683 1092 64259936
Metastases to liver 17.40 9.45 39 237665 23902 64237126
Insomnia 17.39 9.45 576 237128 197260 64063768
Urinary retention 17.38 9.45 108 237596 49093 64211935
Brain oedema 17.36 9.45 140 237564 21935 64239093
Hepatic infarction 17.25 9.45 18 237686 796 64260232
Rhodococcus infection 17.24 9.45 11 237693 238 64260790
Injury 17.24 9.45 128 237576 55864 64205164
Graft infection 17.18 9.45 16 237688 615 64260413
Enthesopathy 17.15 9.45 7 237697 9631 64251397
Paranoia 17.13 9.45 21 237683 16331 64244697
Eschar 17.13 9.45 21 237683 1110 64259918
Delayed engraftment 17.12 9.45 11 237693 241 64260787
Pneumonia necrotising 17.09 9.45 19 237685 904 64260124
Red blood cell schistocytes present 17.05 9.45 15 237689 535 64260493
Microangiopathic haemolytic anaemia 17.03 9.45 23 237681 1339 64259689
Product administration error 17.02 9.45 49 237655 27594 64233434
Hepatitis C 16.96 9.45 83 237621 10932 64250096
Menstruation irregular 16.92 9.45 45 237659 4390 64256638
Hepatitis cholestatic 16.90 9.45 89 237615 12066 64248962
Lower limb fracture 16.89 9.45 15 237689 13530 64247498
Hypokalaemia 16.87 9.45 332 237372 121571 64139457
Fibromyalgia 16.83 9.45 71 237633 35660 64225368
B-lymphocyte count increased 16.83 9.45 9 237695 138 64260890
Hypoproteinaemia 16.83 9.45 38 237666 3344 64257684
Dyspnoea exertional 16.80 9.45 182 237522 73548 64187480
Retinal detachment 16.78 9.45 66 237638 7910 64253118
Coma scale abnormal 16.78 9.45 4 237700 7770 64253258
Fracture 16.74 9.45 27 237677 18728 64242300
Nosocomial infection 16.72 9.45 32 237672 2505 64258523
Erythema infectiosum 16.72 9.45 10 237694 192 64260836
Injection site induration 16.71 9.45 6 237698 8926 64252102
Myoclonus 16.60 9.45 43 237661 25075 64235953
Dermatophytosis 16.60 9.45 13 237691 393 64260635
Chronic graft versus host disease in liver 16.57 9.45 15 237689 556 64260472
Herpes simplex meningoencephalitis 16.56 9.45 7 237697 61 64260967
Perineal ulceration 16.56 9.45 7 237697 61 64260967
Eye infection toxoplasmal 16.55 9.45 14 237690 473 64260555
Joint tuberculosis 16.55 9.45 9 237695 143 64260885
Pyelonephritis acute 16.55 9.45 49 237655 5085 64255943
Splenic necrosis 16.55 9.45 8 237696 98 64260930
Respiratory distress 16.53 9.45 278 237426 52053 64208975
Impaired work ability 16.52 9.45 19 237685 15200 64245828
Microangiopathy 16.51 9.45 24 237680 1497 64259531
Swollen joint count increased 16.51 9.45 4 237700 7685 64253343
Ophthalmoplegia 16.50 9.45 33 237671 2669 64258359
Joint swelling 16.45 9.45 638 237066 214744 64046284
Hepatitis E 16.44 9.45 31 237673 2400 64258628
Chorioretinitis 16.43 9.45 16 237688 651 64260377
Trichophytosis 16.40 9.45 12 237692 327 64260701
Blastomycosis 16.38 9.45 14 237690 480 64260548
Muscle twitching 16.36 9.45 28 237676 18970 64242058
Vesicoureteric reflux 16.33 9.45 8 237696 101 64260927
Chemotherapeutic drug level above therapeutic 16.27 9.45 7 237697 64 64260964
Encephalitis brain stem 16.23 9.45 10 237694 203 64260825
Chimerism 16.21 9.45 11 237693 265 64260763
Amoebiasis 16.20 9.45 8 237696 103 64260925
Hypocalcaemia 16.16 9.45 89 237615 41664 64219364
Optic neuritis 16.15 9.45 66 237638 8050 64252978
Blood pressure decreased 16.14 9.45 222 237482 85977 64175051
Fungal endocarditis 16.14 9.45 14 237690 490 64260538
Disseminated varicella zoster virus infection 16.14 9.45 11 237693 267 64260761
Hypersomnia 16.13 9.45 30 237674 19687 64241341
Acne fulminans 16.12 9.45 9 237695 151 64260877
Flatulence 16.11 9.45 72 237632 35594 64225434
Haematopoietic stem cell mobilisation 16.10 9.45 10 237694 206 64260822
Delirium 16.09 9.45 170 237534 69024 64192004
Orbital apex syndrome 16.08 9.45 7 237697 66 64260962
Exophthalmos 16.05 9.45 24 237680 1536 64259492
Neoplasm progression 16.03 9.45 87 237617 40877 64220151
Arterial spasm 16.01 9.45 9 237695 153 64260875
Oral pain 16.01 9.45 50 237654 27443 64233585
Activated partial thromboplastin time shortened 16.00 9.45 17 237687 768 64260260
Varicella 15.99 9.45 32 237672 2589 64258439
Polyglandular disorder 15.96 9.45 6 237698 37 64260991
Intestinal obstruction 15.95 9.45 74 237630 36212 64224816
Skin irritation 15.85 9.45 7 237697 9187 64251841
Allergy to plants 15.84 9.45 15 237689 589 64260439
Granulomatous liver disease 15.84 9.45 21 237683 1201 64259827
Headache 15.83 9.45 1709 235995 527758 63733270
Torulopsis infection 15.83 9.45 6 237698 38 64260990
Disseminated blastomycosis 15.80 9.45 8 237696 109 64260919
Allergy test positive 15.79 9.45 13 237691 423 64260605
Viral infection 15.75 9.45 203 237501 35937 64225091
Mycobacterium kansasii infection 15.75 9.45 11 237693 278 64260750
Tri-iodothyronine free decreased 15.72 9.45 12 237692 349 64260679
Liver abscess 15.71 9.45 49 237655 5231 64255797
Acute endocarditis 15.69 9.45 5 237699 17 64261011
Blood creatine phosphokinase increased 15.67 9.45 139 237565 58419 64202609
Haemorrhagic varicella syndrome 15.67 9.45 4 237700 4 64261024
Meningitis exserohilum 15.67 9.45 4 237700 4 64261024
Complications of transplanted liver 15.67 9.45 12 237692 351 64260677
Premenstrual syndrome 15.67 9.45 14 237690 510 64260518
Cryptococcal cutaneous infection 15.66 9.45 9 237695 160 64260868
Pleural mass 15.64 9.45 7 237697 71 64260957
Therapy partial responder 15.62 9.45 77 237627 10171 64250857
Parathyroid hyperplasia 15.61 9.45 9 237695 161 64260867
Pneumonia lipoid 15.61 9.45 9 237695 161 64260867
Viral cardiomyopathy 15.57 9.45 6 237698 40 64260988
Amnesia 15.51 9.45 109 237595 48160 64212868
Renal artery stenosis 15.49 9.45 34 237670 2935 64258093
Blood parathyroid hormone decreased 15.49 9.45 4 237700 7362 64253666
Intra-abdominal haemorrhage 15.48 9.45 41 237663 3990 64257038
Cutaneous malacoplakia 15.47 9.45 7 237697 73 64260955
Radiotherapy to brain 15.44 9.45 6 237698 41 64260987
Transient hypogammaglobulinaemia of infancy 15.44 9.45 6 237698 41 64260987
Anaemia 15.40 9.45 1194 236510 377486 63883542
Pyometra 15.38 9.45 7 237697 74 64260954
Blood lactate dehydrogenase increased 15.36 9.45 188 237516 32890 64228138
Cerebellar stroke 15.35 9.45 13 237691 440 64260588
Hepatitis acute 15.29 9.45 93 237611 13296 64247732
Malignant catatonia 15.26 9.45 12 237692 365 64260663
Peritoneal candidiasis 15.26 9.45 5 237699 19 64261009
Thyroid gland abscess 15.22 9.45 7 237697 76 64260952
Sopor 15.20 9.45 57 237647 29604 64231424
Necrosis 15.13 9.45 65 237639 8106 64252922
Burning sensation 15.07 9.45 114 237590 49550 64211478
Unmasking of previously unidentified disease 15.06 9.45 24 237680 1623 64259405
Arthritis fungal 15.06 9.45 8 237696 121 64260907
Cavernous sinus thrombosis 14.99 9.45 11 237693 301 64260727
Respiratory disorder 14.97 9.45 201 237503 35910 64225118
Seroconversion test positive 14.97 9.45 6 237698 45 64260983
Lymphocytosis 14.96 9.45 38 237666 3606 64257422
Dementia 14.95 9.45 34 237670 20732 64240296
Seizure 14.88 9.45 485 237219 166407 64094621
Butterfly rash 14.84 9.45 20 237684 1162 64259866
Acid base balance abnormal 14.84 9.45 11 237693 306 64260722
Granuloma 14.83 9.45 56 237648 6585 64254443
Cytomegalovirus duodenitis 14.83 9.45 7 237697 81 64260947
Ovarian fibroma 14.83 9.45 7 237697 81 64260947
Gastrointestinal candidiasis 14.80 9.45 11 237693 307 64260721
Meningitis bacterial 14.77 9.45 29 237675 2314 64258714
Neutrophil count decreased 14.75 9.45 198 237506 76998 64184030
Meningoencephalitis bacterial 14.73 9.45 9 237695 180 64260848
Lip swelling 14.66 9.45 64 237640 31843 64229185
Rhinovirus infection 14.66 9.45 53 237651 6103 64254925
Urinary casts 14.65 9.45 19 237685 1063 64259965
Drug-induced liver injury 14.65 9.45 252 237452 47391 64213637
Growth retardation 14.63 9.45 23 237681 1538 64259490
Disseminated trichosporonosis 14.60 9.45 7 237697 84 64260944
Reticulocytopenia 14.60 9.45 9 237695 183 64260845
Encephalopathy 14.59 9.45 301 237403 58518 64202510
Enterococcal bacteraemia 14.59 9.45 30 237674 2475 64258553
Band neutrophil percentage increased 14.58 9.45 12 237692 390 64260638
Abdominal pain upper 14.58 9.45 513 237191 174517 64086511
Atrial flutter 14.55 9.45 31 237673 19349 64241679
Interleukin-2 receptor increased 14.55 9.45 9 237695 184 64260844
Lupus myocarditis 14.53 9.45 7 237697 85 64260943
Ureteral necrosis 14.53 9.45 7 237697 85 64260943
Sense of oppression 14.51 9.45 22 237682 1425 64259603
Atrioventricular block first degree 14.48 9.45 11 237693 10723 64250305
Aspergilloma 14.42 9.45 13 237691 479 64260549
Salivary hypersecretion 14.41 9.45 14 237690 12099 64248929
Passenger lymphocyte syndrome 14.39 9.45 7 237697 87 64260941
Crying 14.38 9.45 33 237671 20057 64240971
Pregnancy 14.35 9.45 35 237669 20830 64240198
Wound infection bacterial 14.34 9.45 16 237688 764 64260264
Thyroid stimulating immunoglobulin increased 14.32 9.45 7 237697 88 64260940
Diffuse large B-cell lymphoma stage III 14.32 9.45 7 237697 88 64260940
Papilloma viral infection 14.32 9.45 22 237682 1442 64259586
Swelling face 14.32 9.45 144 237560 59022 64202006
Alternaria infection 14.29 9.45 14 237690 574 64260454
Dysgeusia 14.27 9.45 108 237596 46939 64214089
Bronchostenosis 14.27 9.45 14 237690 575 64260453
Neurosarcoidosis 14.26 9.45 11 237693 325 64260703
Epstein-Barr virus test positive 14.26 9.45 18 237686 980 64260048
Mean cell haemoglobin concentration increased 14.23 9.45 16 237688 771 64260257
Acarodermatitis 14.20 9.45 20 237684 1212 64259816
Foetal growth restriction 14.19 9.45 24 237680 1706 64259322
Hepatitis toxic 14.19 9.45 42 237662 4358 64256670
Amoebic dysentery 14.17 9.45 5 237699 25 64261003
Necrotising oesophagitis 14.16 9.45 15 237689 675 64260353
Aeromonas infection 14.12 9.45 11 237693 330 64260698
Hypertensive encephalopathy 14.10 9.45 17 237687 883 64260145
Diabetic macroangiopathy 14.08 9.45 8 237696 139 64260889
Hyperoxaluria 14.04 9.45 10 237694 261 64260767
Arteritis coronary 14.03 9.45 6 237698 54 64260974
Meningitis chemical 14.01 9.45 9 237695 197 64260831
Tularaemia 13.98 9.45 7 237697 93 64260935
Surgery 13.96 9.45 55 237649 28158 64232870
Extremity necrosis 13.92 9.45 31 237673 2703 64258325
Bundle branch block left 13.90 9.45 10 237694 10024 64251004
Dry skin 13.89 9.45 121 237583 51040 64209988
Viral vasculitis 13.88 9.45 8 237696 143 64260885
Dengue fever 13.88 9.45 16 237688 792 64260236
Exostosis 13.86 9.45 13 237691 11425 64249603
Infected varicose vein 13.85 9.45 5 237699 27 64261001
Myocardiac abscess 13.85 9.45 5 237699 27 64261001
Reticuloendothelial dysfunction 13.82 9.45 3 237701 0 64261028
Cestode infection 13.81 9.45 10 237694 268 64260760
Accelerated idioventricular rhythm 13.78 9.45 8 237696 145 64260883
Pelvic venous thrombosis 13.76 9.45 24 237680 1749 64259279
Pneumatosis 13.75 9.45 16 237688 800 64260228
Blood urea increased 13.74 9.45 234 237470 43919 64217109
Autoimmune colitis 13.74 9.45 21 237683 1370 64259658
Inadequate aseptic technique in use of product 13.72 9.45 7 237697 97 64260931
Vaginal haemorrhage 13.66 9.45 32 237672 19312 64241716
Viral load abnormal 13.65 9.45 6 237698 58 64260970
Small intestinal obstruction 13.64 9.45 43 237661 23530 64237498
Blood sodium decreased 13.63 9.45 59 237645 29423 64231605
Hepatitis A 13.63 9.45 16 237688 808 64260220
Glomerulonephritis membranoproliferative 13.62 9.45 13 237691 516 64260512
Skin necrosis 13.60 9.45 95 237609 14234 64246794
Hepatosplenomegaly 13.58 9.45 47 237657 5296 64255732
Ureteric anastomosis complication 13.56 9.45 5 237699 29 64260999
Cholelithiasis 13.55 9.45 105 237599 45401 64215627
Acinetobacter bacteraemia 13.51 9.45 9 237695 210 64260818
Parkinsonism 13.49 9.45 20 237684 14353 64246675
Hairy cell leukaemia 13.48 9.45 6 237698 60 64260968
Type IIb hyperlipidaemia 13.42 9.45 5 237699 30 64260998
Electrocardiogram abnormal 13.41 9.45 18 237686 13463 64247565
Poor venous access 13.40 9.45 85 237619 12332 64248696
Osteoarthritis 13.39 9.45 159 237545 63177 64197851
Granuloma skin 13.36 9.45 3 237701 6071 64254957
Cystitis viral 13.33 9.45 14 237690 624 64260404
Pneumonia influenzal 13.29 9.45 29 237675 2493 64258535
Temperature intolerance 13.29 9.45 63 237641 8192 64252836
Candida test positive 13.27 9.45 18 237686 1052 64259976
Hepatic cyst infection 13.27 9.45 8 237696 156 64260872
Creatinine urine decreased 13.25 9.45 9 237695 217 64260811
Vasculitis necrotising 13.25 9.45 18 237686 1054 64259974
Lymphangitis 13.24 9.45 20 237684 1291 64259737
Pneumonia aspiration 13.23 9.45 147 237557 59124 64201904
Urine leukocyte esterase 13.22 9.45 8 237696 157 64260871
Tendonitis 13.19 9.45 35 237669 20247 64240781
Glomerulonephropathy 13.13 9.45 10 237694 290 64260738
Myelitis 13.13 9.45 26 237678 2088 64258940
Abdominal distension 13.11 9.45 262 237442 95732 64165296
Dehiscence 13.05 9.45 7 237697 108 64260920
Band neutrophil count increased 13.02 9.45 14 237690 641 64260387
Diffuse mesangial sclerosis 13.02 9.45 5 237699 33 64260995
Monocyte count decreased 13.01 9.45 31 237673 2826 64258202
Dysstasia 12.98 9.45 43 237661 23172 64237856
Moyamoya disease 12.98 9.45 6 237698 66 64260962
Gait inability 12.97 9.45 97 237607 42271 64218757
Drug eruption 12.93 9.45 79 237625 36057 64224971
Nephritis 12.92 9.45 36 237668 3610 64257418
Glomerulonephritis membranous 12.91 9.45 20 237684 1320 64259708
Hepatic artery aneurysm 12.89 9.45 5 237699 34 64260994
Encephalitis fungal 12.87 9.45 8 237696 165 64260863
Injection site rash 12.83 9.45 24 237680 15718 64245310
Thyroxine free increased 12.80 9.45 18 237686 1089 64259939
Nephropathy 12.78 9.45 63 237641 8323 64252705
Subcutaneous emphysema 12.77 9.45 22 237682 1587 64259441
Limbic encephalitis 12.74 9.45 14 237690 657 64260371
Sexual dysfunction 12.71 9.45 4 237700 6467 64254561
Cytokine storm 12.68 9.45 16 237688 871 64260157
Retching 12.67 9.45 23 237681 15233 64245795
Epididymitis 12.66 9.45 23 237681 1731 64259297
Creatinine renal clearance decreased 12.65 9.45 21 237683 14400 64246628
Pyuria 12.62 9.45 25 237679 2008 64259020
Anastomotic haemorrhage 12.56 9.45 9 237695 237 64260791
Multisystem inflammatory syndrome in children 12.53 9.45 5 237699 37 64260991
Transfusion 12.52 9.45 30 237674 17964 64243064
Lower gastrointestinal haemorrhage 12.51 9.45 20 237684 13919 64247109
Metabolic encephalopathy 12.49 9.45 7 237697 8018 64253010
Perinephric collection 12.47 9.45 10 237694 313 64260715
Nephrolithiasis 12.45 9.45 102 237602 43581 64217447
Chronic papillomatous dermatitis 12.45 9.45 6 237698 73 64260955
Erectile dysfunction 12.42 9.45 17 237687 12610 64248418
Myelocyte percentage increased 12.40 9.45 9 237695 242 64260786
Atypical haemolytic uraemic syndrome 12.39 9.45 14 237690 678 64260350
Asthma 12.38 9.45 262 237442 94963 64166065
Pneumonia adenoviral 12.38 9.45 8 237696 177 64260851
Haemorrhoids 12.38 9.45 46 237658 23955 64237073
Disability 12.37 9.45 16 237688 12156 64248872
Chromoblastomycosis 12.30 9.45 6 237698 75 64260953
Optic nerve compression 12.25 9.45 4 237700 15 64261013
Dermatitis acneiform 12.25 9.45 8 237696 8435 64252593
Monocyte percentage decreased 12.24 9.45 9 237695 247 64260781
Occult blood 12.24 9.45 20 237684 1382 64259646
Neuralgia 12.23 9.45 149 237555 26035 64234993
Laryngitis 12.21 9.45 76 237628 10955 64250073
Hypocomplementaemia 12.19 9.45 8 237696 182 64260846
Haematuria traumatic 12.19 9.45 8 237696 182 64260846
Haemolysis 12.18 9.45 76 237628 10963 64250065
Excessive skin 12.15 9.45 7 237697 125 64260903
Coronary arterial stent insertion 12.14 9.45 3 237701 5689 64255339
Accident 12.14 9.45 5 237699 6841 64254187
Aspergillus test positive 12.13 9.45 14 237690 694 64260334
Injection site urticaria 12.10 9.45 14 237690 11167 64249861
Back pain 12.09 9.45 777 236927 249394 64011634
Gastritis fungal 12.07 9.45 8 237696 185 64260843
Carotid artery insufficiency 12.05 9.45 4 237700 16 64261012
Bone erosion 12.03 9.45 15 237689 11580 64249448
Hilar lymphadenopathy 12.02 9.45 21 237683 1532 64259496
Femur fracture 12.02 9.45 75 237629 34060 64226968
Illness 12.01 9.45 41 237663 21897 64239131
Wolff-Parkinson-White syndrome 12.00 9.45 9 237695 255 64260773
Drug level decreased 11.95 9.45 78 237626 11425 64249603
Infertility 11.89 9.45 12 237692 510 64260518
Cervicitis 11.89 9.45 8 237696 190 64260838
Aortic pseudoaneurysm 11.89 9.45 5 237699 43 64260985
Needle issue 11.88 9.45 10 237694 9262 64251766
Influenza like illness 11.88 9.45 158 237546 61544 64199484
Eosinophil percentage decreased 11.82 9.45 9 237695 261 64260767
Encephalomyelitis 11.81 9.45 8 237696 192 64260836
Lung neoplasm malignant 11.80 9.45 40 237664 21408 64239620
Incorrect route of product administration 11.79 9.45 45 237659 23253 64237775
Peripheral vascular disorder 11.79 9.45 6 237698 7255 64253773
Rash erythematous 11.78 9.45 248 237456 48385 64212643
Moraxella infection 11.78 9.45 12 237692 516 64260512
Immunoglobulins decreased 11.77 9.45 19 237685 1299 64259729
Sensitivity to weather change 11.75 9.45 5 237699 6709 64254319
Cerebral venous sinus thrombosis 11.74 9.45 23 237681 1832 64259196
Mucocutaneous leishmaniasis 11.72 9.45 11 237693 427 64260601
Cytomegalovirus mucocutaneous ulcer 11.70 9.45 6 237698 84 64260944
Central obesity 11.69 9.45 20 237684 1435 64259593
Blood 1,25-dihydroxycholecalciferol increased 11.68 9.45 4 237700 18 64261010
Stomatitis necrotising 11.67 9.45 8 237696 196 64260832
Mucosal ulceration 11.65 9.45 22 237682 1705 64259323
Mouth ulceration 11.62 9.45 176 237528 32268 64228760
Haemostasis 11.58 9.45 9 237695 269 64260759
Jaundice cholestatic 11.55 9.45 9 237695 8661 64252367
X-ray limb abnormal 11.50 9.45 4 237700 19 64261009
Renal hypertrophy 11.50 9.45 5 237699 47 64260981
Urine bilirubin decreased 11.50 9.45 7 237697 139 64260889
Chronic hepatitis C 11.50 9.45 12 237692 531 64260497
Pruritus 11.48 9.45 993 236711 311407 63949621
Drug hypersensitivity 11.43 9.45 739 236965 237076 64023952
Thrombotic thrombocytopenic purpura 11.39 9.45 48 237656 5936 64255092
Bacterial pyelonephritis 11.39 9.45 12 237692 537 64260491
Personality change 11.35 9.45 9 237695 8584 64252444
Arthritis bacterial 11.32 9.45 58 237646 7781 64253247
Body temperature increased 11.29 9.45 194 237510 36472 64224556
Coccidioidomycosis 11.26 9.45 17 237687 1097 64259931
Respiratory gas exchange disorder 11.26 9.45 14 237690 751 64260277
Oral candidiasis 11.24 9.45 133 237571 23079 64237949
Expired product administered 11.24 9.45 4 237700 5983 64255045
Central pain syndrome 11.22 9.45 9 237695 282 64260746
Hypofibrinogenaemia 11.20 9.45 22 237682 1756 64259272
Globulins decreased 11.20 9.45 10 237694 364 64260664
Glomerulonephritis proliferative 11.17 9.45 10 237694 365 64260663
Cerebellar ataxia 11.16 9.45 22 237682 1761 64259267
Bile duct stenosis 11.15 9.45 22 237682 1762 64259266
Magnesium deficiency 11.14 9.45 12 237692 551 64260477
Depressed mood 11.13 9.45 97 237607 40915 64220113
Neutropenic sepsis 11.11 9.45 46 237658 23226 64237802
Road traffic accident 11.11 9.45 67 237637 30678 64230350
Intracardiac mass 11.11 9.45 6 237698 94 64260934
Musculoskeletal pain 11.06 9.45 222 237482 81072 64179956
Bacterial vulvovaginitis 11.05 9.45 11 237693 460 64260568
Drug tolerance decreased 11.04 9.45 6 237698 6992 64254036
Germ cell cancer 11.03 9.45 7 237697 150 64260878
Acinetobacter test positive 11.03 9.45 8 237696 215 64260813
Chronic graft versus host disease in skin 11.02 9.45 19 237685 1372 64259656
Nocturia 11.01 9.45 15 237689 11150 64249878
Fear of injection 11.01 9.45 4 237700 5908 64255120
Lower respiratory tract infection bacterial 11 9.45 13 237691 661 64260367
Biopsy lymph gland 11.00 9.45 6 237698 96 64260932
Pancreatitis 10.98 9.45 154 237550 59453 64201575
Phaeohyphomycotic brain abscess 10.98 9.45 5 237699 53 64260975
Weight increased 10.97 9.45 921 236783 212427 64048601
Gastrointestinal haemorrhage 10.97 9.45 388 237316 131924 64129104
Muscle abscess 10.97 9.45 15 237689 884 64260144
Familial periodic paralysis 10.95 9.45 7 237697 152 64260876
Nephrogenic systemic fibrosis 10.95 9.45 4 237700 5888 64255140
Herpes zoster cutaneous disseminated 10.95 9.45 10 237694 375 64260653
Angioedema 10.94 9.45 161 237543 61660 64199368
Erythrosis 10.89 9.45 6 237698 98 64260930
Hepatic cancer 10.89 9.45 7 237697 7441 64253587
Perforation 10.88 9.45 17 237687 1131 64259897
Arteriovenous fistula 10.88 9.45 15 237689 891 64260137
Product complaint 10.87 9.45 17 237687 11937 64249091
Mean cell volume decreased 10.86 9.45 33 237671 3473 64257555
Oropharyngeal plaque 10.86 9.45 10 237694 379 64260649
Erosive duodenitis 10.86 9.45 21 237683 1657 64259371
Cystitis escherichia 10.85 9.45 11 237693 470 64260558
Ventricular extrasystoles 10.84 9.45 31 237673 17498 64243530
Colitis microscopic 10.84 9.45 7 237697 7425 64253603
Neuropathy peripheral 10.84 9.45 340 237364 117185 64143843
Alopecia scarring 10.83 9.45 6 237698 99 64260929
Eye abscess 10.82 9.45 9 237695 297 64260731
Paradoxical drug reaction 10.81 9.45 48 237656 6072 64254956
Pterygium 10.80 9.45 9 237695 298 64260730
Biliary anastomosis complication 10.79 9.45 7 237697 156 64260872
Nose deformity 10.79 9.45 7 237697 156 64260872
Abnormal loss of weight 10.75 9.45 7 237697 7393 64253635
Adjusted calcium decreased 10.75 9.45 7 237697 157 64260871
Coombs direct test positive 10.75 9.45 10 237694 384 64260644
Castleman's disease 10.73 9.45 4 237700 24 64261004
White blood cell count increased 10.73 9.45 319 237385 65695 64195333
Depression 10.71 9.45 559 237145 182732 64078296
Retinal scar 10.71 9.45 10 237694 386 64260642
Eosinophil percentage increased 10.69 9.45 19 237685 1405 64259623
Hyperpyrexia 10.67 9.45 42 237662 5035 64255993
Cryptococcal fungaemia 10.64 9.45 7 237697 160 64260868
Double stranded DNA antibody positive 10.62 9.45 10 237694 390 64260638
Body temperature decreased 10.62 9.45 144 237560 25784 64235244
Tenosynovitis 10.60 9.45 17 237687 11816 64249212
Community acquired infection 10.60 9.45 4 237700 25 64261003
Adrenal atrophy 10.58 9.45 5 237699 58 64260970
Scleroderma renal crisis 10.58 9.45 10 237694 392 64260636
Sinus node dysfunction 10.56 9.45 6 237698 6822 64254206
Joint injury 10.56 9.45 46 237658 22901 64238127
Osseous cryptococcosis 10.55 9.45 3 237701 6 64261022
Haptoglobin abnormal 10.55 9.45 3 237701 6 64261022
Splenic infection fungal 10.52 9.45 6 237698 105 64260923
Lactic acidosis 10.50 9.45 161 237543 61249 64199779
Jejunal perforation 10.49 9.45 9 237695 310 64260718
Prescribed overdose 10.47 9.45 39 237665 20292 64240736
Biliary ischaemia 10.46 9.45 4 237700 26 64261002
Stupor 10.41 9.45 47 237657 5988 64255040
Porokeratosis 10.39 9.45 8 237696 236 64260792
Bilirubin conjugated increased 10.36 9.45 41 237663 4927 64256101
Meningomyelitis herpes 10.36 9.45 5 237699 61 64260967
Vitamin B1 decreased 10.35 9.45 9 237695 316 64260712
Glomerulonephritis rapidly progressive 10.34 9.45 18 237686 1310 64259718
Blood potassium decreased 10.33 9.45 97 237607 40302 64220726
Mycobacterium avium complex infection 10.31 9.45 35 237669 3905 64257123
Bursitis infective 10.31 9.45 17 237687 1183 64259845
Tracheobronchitis 10.31 9.45 21 237683 1721 64259307
Wrong product administered 10.30 9.45 8 237696 7712 64253316
Endometrial disorder 10.30 9.45 11 237693 500 64260528
Salivary gland mass 10.29 9.45 5 237699 62 64260966
Withdrawal syndrome 10.27 9.45 48 237656 23444 64237584
Panic attack 10.27 9.45 41 237663 20912 64240116
Genital herpes 10.23 9.45 22 237682 1873 64259155
Drug level below therapeutic 10.22 9.45 54 237650 7330 64253698
Thrombosis in device 10.20 9.45 3 237701 5068 64255960
Cytomegalovirus gastritis 10.19 9.45 10 237694 411 64260617
Viral sepsis 10.18 9.45 6 237698 112 64260916
Middle insomnia 10.18 9.45 20 237684 12857 64248171
Internal haemorrhage 10.16 9.45 8 237696 7659 64253369
Glycosylated haemoglobin increased 10.15 9.45 28 237676 15991 64245037
Refractory anaemia with an excess of blasts 10.15 9.45 14 237690 832 64260196
Breast cancer metastatic 10.12 9.45 7 237697 7162 64253866
Paraesthesia ear 10.12 9.45 7 237697 174 64260854
Ischaemic stroke 10.11 9.45 64 237640 28971 64232057
Bone marrow disorder 10.11 9.45 28 237676 2797 64258231
Disseminated cytomegaloviral infection 10.11 9.45 10 237694 415 64260613
Red cell distribution width decreased 10.10 9.45 16 237688 1077 64259951
Skin lesion inflammation 10.09 9.45 4 237700 29 64260999
Pseudopolyposis 10.08 9.45 5 237699 65 64260963
Fungal peritonitis 10.08 9.45 15 237689 956 64260072
Abscess fungal 10.07 9.45 8 237696 247 64260781
Cardiac pacemaker insertion 10.05 9.45 3 237701 5020 64256008
Hospice care 10.05 9.45 8 237696 7617 64253411
Cytomegalovirus gastroenteritis 10.03 9.45 10 237694 419 64260609
Muscle rigidity 10.02 9.45 32 237672 17441 64243587
Infective thrombosis 10.01 9.45 5 237699 66 64260962
Sebaceous carcinoma 10.00 9.45 6 237698 116 64260912
Chorioretinal folds 9.98 9.45 4 237700 30 64260998
Cancer in remission 9.98 9.45 4 237700 30 64260998
Hyperplasia 9.98 9.45 16 237688 1088 64259940
Secretion discharge 9.97 9.45 18 237686 11946 64249082
Presyncope 9.97 9.45 82 237622 35007 64226021
Post transplant distal limb syndrome 9.97 9.45 11 237693 519 64260509
Palatal ulcer 9.91 9.45 6 237698 118 64260910
Dental caries 9.90 9.45 71 237633 10729 64250299
Type 2 diabetes mellitus 9.89 9.45 79 237625 33941 64227087
Second primary malignancy 9.89 9.45 19 237685 12318 64248710
Breast abscess 9.88 9.45 16 237688 1097 64259931
Thyroid stimulating immunoglobulin 9.88 9.45 5 237699 68 64260960
SARS-CoV-2 RNA 9.87 9.45 4 237700 31 64260997
Tricuspid valve incompetence 9.85 9.45 31 237673 16972 64244056
Fungal sepsis 9.83 9.45 20 237684 1638 64259390
Pericarditis infective 9.82 9.45 6 237698 120 64260908
Histiocytic sarcoma 9.82 9.45 5 237699 69 64260959
Viral myocarditis 9.81 9.45 10 237694 430 64260598
Abnormal behaviour 9.81 9.45 78 237626 33544 64227484
Waxy flexibility 9.80 9.45 8 237696 257 64260771
Nail bed inflammation 9.78 9.45 11 237693 530 64260498
Normochromic anaemia 9.78 9.45 10 237694 432 64260596
Renal atrophy 9.78 9.45 20 237684 1644 64259384
Ventricular tachycardia 9.77 9.45 80 237624 34185 64226843
Renal haemorrhage 9.76 9.45 22 237682 1933 64259095
Eosinophilic granulomatosis with polyangiitis 9.76 9.45 28 237676 2854 64258174
Tongue fungal infection 9.76 9.45 4 237700 32 64260996
Chorioretinal scar 9.75 9.45 5 237699 70 64260958
Dysarthria 9.74 9.45 157 237547 59249 64201779
Hallucination, auditory 9.73 9.45 31 237673 16908 64244120
Respiratory tract congestion 9.70 9.45 29 237675 16136 64244892
Subdural haematoma 9.69 9.45 62 237642 27992 64233036
Oral discomfort 9.67 9.45 10 237694 8396 64252632
Disorientation 9.67 9.45 146 237558 55682 64205346
Small intestinal perforation 9.66 9.45 26 237678 2554 64258474
Oral fungal infection 9.66 9.45 29 237675 3032 64257996
Idiopathic pneumonia syndrome 9.65 9.45 11 237693 538 64260490
Arterial thrombosis 9.62 9.45 25 237679 2405 64258623
Glomerulonephritis chronic 9.62 9.45 8 237696 264 64260764
Eye infection fungal 9.61 9.45 10 237694 441 64260587
Hyperammonaemia 9.60 9.45 66 237638 9838 64251190
Catheterisation cardiac 9.59 9.45 3 237701 4870 64256158
Adenomatous polyposis coli 9.59 9.45 7 237697 190 64260838
Type I hypersensitivity 9.58 9.45 32 237672 3542 64257486
Laryngeal mass 9.57 9.45 5 237699 73 64260955
Liver function test 9.56 9.45 6 237698 126 64260902
Ulcer 9.54 9.45 128 237576 22862 64238166
Hypoacusis 9.54 9.45 56 237648 25811 64235217
Alcohol abuse 9.53 9.45 3 237701 4849 64256179
Cells in urine 9.53 9.45 7 237697 192 64260836
Pneumonia legionella 9.52 9.45 25 237679 2421 64258607
Renal vein thrombosis 9.50 9.45 10 237694 447 64260581
Organic brain syndrome 9.48 9.45 10 237694 448 64260580
Pyogenic granuloma 9.46 9.45 10 237694 449 64260579
Hypomagnesaemia 9.45 9.45 90 237614 37286 64223742

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D07AA01 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, PLAIN
Corticosteroids, weak (group I)
ATC D07CA02 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, COMBINATIONS WITH ANTIBIOTICS
Corticosteroids, weak, combinations with antibiotics
ATC D10AA02 DERMATOLOGICALS
ANTI-ACNE PREPARATIONS
ANTI-ACNE PREPARATIONS FOR TOPICAL USE
Corticosteroids, combinations for treatment of acne
ATC H02AB04 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
CORTICOSTEROIDS FOR SYSTEMIC USE
CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
Glucocorticoids
ATC H02BX01 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
CORTICOSTEROIDS FOR SYSTEMIC USE
CORTICOSTEROIDS FOR SYSTEMIC USE, COMBINATIONS
Corticosteroids for systemic use, combinations
ATC S01CA08 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids and antiinfectives in combination
FDA MoA N0000175450 Corticosteroid Hormone Receptor Agonists
FDA EPC N0000175576 Corticosteroid
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000932 Antiemetics
MeSH PA D002491 Central Nervous System Agents
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D005938 Glucocorticoids
MeSH PA D006728 Hormones
MeSH PA D018696 Neuroprotective Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D020011 Protective Agents
CHEBI has role CHEBI:35472 anti-inflammatory drugs
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:37962 adrenergic agents
CHEBI has role CHEBI:50919 antiemetico
CHEBI has role CHEBI:63726 neuroprotective agents
CHEBI has role CHEBI:78298 environmental contaminants

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Disorder of musculoskeletal system indication 928000 DOID:17
Cerebral edema indication 2032001
Berylliosis indication 8247009 DOID:10322
Psoriasis indication 9014002 DOID:8893
Ankylosing spondylitis indication 9631008 DOID:7147
Rheumatic heart disease indication 23685000
Atopic dermatitis indication 24079001 DOID:3310
Inflammatory bowel disease indication 24526004 DOID:0050589
Multiple sclerosis indication 24700007 DOID:2377
Severe adrenal insufficiency indication 24867002
Sarcoidosis indication 31541009 DOID:11335
Idiopathic thrombocytopenic purpura indication 32273002 DOID:8924
Psoriasis with arthropathy indication 33339001
Crohn's disease indication 34000006
Tendinitis indication 34840004 DOID:971
Erythema multiforme indication 36715001
Contact dermatitis indication 40275004 DOID:2773
Angioedema indication 41291007 DOID:1558
Miliary tuberculosis indication 47604008 DOID:9861
Humoral hypercalcemia of malignancy indication 47709007
Articular gout indication 48440001 DOID:13189
Seborrheic dermatitis indication 50563003 DOID:8741
Edema of larynx indication 51599000
Nephrotic syndrome indication 52254009 DOID:1184
Lichen simplex chronicus indication 53891004
Systemic lupus erythematosus indication 55464009 DOID:9074
Allergic rhinitis indication 61582004
Löffler's syndrome indication 64936001 DOID:9503
Pemphigus indication 65172003 DOID:9182
Granuloma annulare indication 65508009 DOID:3777
Tenosynovitis indication 67801009 DOID:970
Rheumatoid arthritis indication 69896004 DOID:7148
Transfusion reaction due to serum protein reaction indication 72284000
Epicondylitis indication 73583000 DOID:14087
Acquired thrombocytopenia indication 74576004 DOID:11126
Thyroiditis indication 82119001 DOID:7166
Bursitis indication 84017003 DOID:2965
Autoimmune disease indication 85828009
Infection by larvae of Trichinella spiralis indication 88264003
Congenital hypoplastic anemia indication 88854002 DOID:1339
Pruritus ani indication 90446007
Acute lymphoid leukemia indication 91857003 DOID:9952
Disorder of skin indication 95320005 DOID:37
Dermatitis herpetiformis indication 111196000 DOID:8505
Hodgkin's disease indication 118599009
Non-Hodgkin's lymphoma indication 118601006
Mycosis fungoides indication 118618005
Aspiration pneumonitis indication 155597006
Asthma indication 195967001 DOID:2841
Discoid lupus erythematosus indication 200938002
Plaque psoriasis indication 200965009
Transplanted organ rejection indication 213148006
Congenital adrenal hyperplasia indication 237751000
Scalp psoriasis indication 238608008
Adrenogenital disorder indication 267395000 DOID:0050811
Pruritus of genital organs indication 267802000
Eruption of skin indication 271807003 DOID:0050486
Exacerbation of asthma indication 281239006
Follicular non-Hodgkin's lymphoma indication 308121000
Disorder of eye indication 371405004 DOID:5614
Primary adrenocortical insufficiency indication 373662000
Adrenal cortical hypofunction indication 386584007 DOID:10493
Erythroderma indication 399992009
Primary cutaneous T-cell lymphoma indication 400122007
Juvenile rheumatoid arthritis indication 410795001
Autoimmune hemolytic anemia indication 413603009 DOID:718
Synovitis indication 416209007 DOID:2703
Post traumatic osteoarthritis indication 699262001
Systemic Dermatomyositis indication
Diagnostic Test for Cushing's Syndrome indication
Synovitis due to Osteoarthritis indication
Transfusion Reaction Urticaria indication
Progressive Diffuse Large B-Cell Lymphoma indication
Erythroblastic Anemia indication
Pericarditis off-label use 3238004 DOID:1787
Chronic obstructive lung disease off-label use 13645005 DOID:3083
Pulmonary edema off-label use 19242006 DOID:11396
Shock off-label use 27942005
West syndrome off-label use 28055006
Vasculitis off-label use 31996006 DOID:865
Bronchitis off-label use 32398004 DOID:6132
Anaphylaxis off-label use 39579001
Eczema off-label use 43116000
Respiratory distress syndrome in the newborn off-label use 46775006
Nasal polyp off-label use 52756005
Rheumatic fever off-label use 58718002 DOID:1586
Pseudogout off-label use 60782007
Polymyalgia rheumatica off-label use 65323003 DOID:853
Chronic hepatitis off-label use 76783007 DOID:2237
Pemphigoid off-label use 86142006
Hepatic necrosis off-label use 87248009
Multiple myeloma off-label use 109989006 DOID:9538
Polyarteritis nodosa off-label use 155441006 DOID:9810
Coronavirus infection off-label use 186747009
Celiac disease off-label use 396331005 DOID:10608
Carditis off-label use 399617002
Giant cell arteritis off-label use 414341000 DOID:13375
Neonatal Bronchopulmonary Dysplasia off-label use
Prevention of Post-Extubation Laryngeal Edema off-label use
Metastatic Prostate Carcinoma off-label use
Hypercalcemia associated with Sarcoidosis off-label use
Neuroendocrine Prostate Carcinoma off-label use
Prevention of Lung Transplant Rejection off-label use
Prevention of Cardiac Transplant Rejection off-label use
Infection by Strongyloides contraindication 1214006 DOID:10955
Mycosis contraindication 3218000 DOID:1564
Gastritis contraindication 4556007 DOID:4029
Inactive tuberculosis contraindication 11999007
Peptic ulcer contraindication 13200003 DOID:750
Hypercholesterolemia contraindication 13644009
Measles contraindication 14189004 DOID:8622
Cirrhosis of liver contraindication 19943007 DOID:5082
Arginase deficiency contraindication 23501004 DOID:9278
Immunosuppression contraindication 38013005
Hypertensive disorder contraindication 38341003 DOID:10763
Infectious disease contraindication 40733004
Hypothyroidism contraindication 40930008 DOID:1459
Hypokalemia contraindication 43339004
Chronic heart failure contraindication 48447003
Cerebral malaria contraindication 53622003 DOID:14069
Tuberculosis contraindication 56717001
Congenital hyperammonemia, type I contraindication 62522004
Osteoporosis contraindication 64859006 DOID:11476
Psychotic disorder contraindication 69322001
Diabetes mellitus contraindication 73211009 DOID:9351
Hypopituitarism contraindication 74728003 DOID:9406
Hyperglycemia contraindication 80394007 DOID:4195
Open-angle glaucoma contraindication 84494001 DOID:1067
Muscle atrophy contraindication 88092000 DOID:767
Herpes simplex contraindication 88594005 DOID:8566
Bilateral cataracts contraindication 95722004
Seizure disorder contraindication 128613002
Disorder of muscle contraindication 129565002 DOID:423
Ophthalmic herpes simplex contraindication 186542001
Skin striae contraindication 201066002
Anastomosis of intestine contraindication 235407009
Telangiectasia disorder contraindication 247479008
Edema contraindication 267038008
Pathological fracture contraindication 268029009
Diverticulitis of gastrointestinal tract contraindication 271366000
Cerebral trauma contraindication 275382005
Pregnancy, function contraindication 289908002
Varicella-zoster virus infection contraindication 309465005
Osteopenia contraindication 312894000
Avascular necrosis of bone contraindication 397758007 DOID:10159
Citrullinemia contraindication 398680004 DOID:9273
Atrophoderma contraindication 399979006
Traumatic rupture of tendon contraindication 415749005
Exposure to varicella contraindication 444453009
Ornithine Carbamyltransferase Deficiency contraindication
Arginosuccinate Lyase Deficiency contraindication




🐶 Veterinary Drug Use

SpeciesUseRelation
Cats Inflammation and related disorders Indication
Cats Allergic and dermatologic disorders Indication
Cats Supportive therapy to antibacterial treatment of severe infections Indication
Dogs Inflammation and related disorders Indication
Dogs Allergic and dermatologic disorders Indication
Dogs Supportive therapy to antibacterial treatment of severe infections Indication
Horses Inflammation and related disorders Indication

🐶 Veterinary products

ProductApplicantIngredients
Medrol Tablets Zoetis Inc. 1
Cortaba Tablets Zoetis Inc. 2
Methylprednisolene Tablets Cronus Pharma Specialities India Private Limited 1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.18 acidic
pKa2 12.89 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST EC50 8.50 WOMBAT-PK CHEMBL
Annexin A1 Cytosolic other WOMBAT-PK
Short transient receptor potential channel 5 Ion channel ACTIVATOR EC50 4.92 IUPHAR
Androgen receptor Transcription factor Ki 4.75 DRUG MATRIX

External reference:

IDSource
4018068 VUID
N0000146409 NUI
D00407 KEGG_DRUG
4018068 VANDF
C0025815 UMLSCUI
CHEBI:6888 CHEBI
CHEMBL1201081 ChEMBL_ID
CHEMBL650 ChEMBL_ID
DB00959 DRUGBANK_ID
D008775 MESH_DESCRIPTOR_UI
6741 PUBCHEM_CID
7088 IUPHAR_LIGAND_ID
732 INN_ID
X4W7ZR7023 UNII
6902 RXNORM
1041 MMSL
5093 MMSL
7130 MMSL
d00293 MMSL
002160 NDDF
116593003 SNOMEDCT_US
27242001 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Medrol HUMAN PRESCRIPTION DRUG LABEL 1 0009-0020 TABLET 2 mg ORAL NDA 16 sections
Medrol HUMAN PRESCRIPTION DRUG LABEL 1 0009-0022 TABLET 8 mg ORAL NDA 16 sections
Medrol HUMAN PRESCRIPTION DRUG LABEL 1 0009-0049 TABLET 2 mg ORAL NDA 16 sections
Medrol HUMAN PRESCRIPTION DRUG LABEL 1 0009-0056 TABLET 4 mg ORAL NDA 16 sections
Medrol HUMAN PRESCRIPTION DRUG LABEL 1 0009-0073 TABLET 16 mg ORAL NDA 16 sections
Medrol HUMAN PRESCRIPTION DRUG LABEL 1 0009-0176 TABLET 32 mg ORAL NDA 16 sections
MethylPREDNISolone HUMAN PRESCRIPTION DRUG LABEL 1 0603-4593 TABLET 4 mg ORAL ANDA 13 sections
Methylprednisolone HUMAN PRESCRIPTION DRUG LABEL 1 0781-5022 TABLET 4 mg ORAL ANDA 15 sections
methylprednisolone HUMAN PRESCRIPTION DRUG LABEL 1 0904-6914 TABLET 4 mg ORAL ANDA 13 sections
METHYLPREDNISOLONE HUMAN PRESCRIPTION DRUG LABEL 1 16590-149 TABLET 4 mg ORAL ANDA 11 sections
Medrol HUMAN PRESCRIPTION DRUG LABEL 1 16590-879 TABLET 4 mg ORAL NDA 11 sections
Methylprednisolone HUMAN PRESCRIPTION DRUG LABEL 1 21695-080 TABLET 4 mg ORAL ANDA 12 sections
Methylprednisolone HUMAN PRESCRIPTION DRUG LABEL 1 33261-335 TABLET 4 mg ORAL ANDA 12 sections
METHYLPREDNISOLONE HUMAN PRESCRIPTION DRUG LABEL 1 42549-522 TABLET 4 mg ORAL ANDA 12 sections
METHYLPREDNISOLONE HUMAN PRESCRIPTION DRUG LABEL 1 42806-400 TABLET 4 mg ORAL ANDA 15 sections
Methylprednisolone HUMAN PRESCRIPTION DRUG LABEL 1 45865-104 TABLET 4 mg ORAL ANDA 15 sections
Methylprednisolone HUMAN PRESCRIPTION DRUG LABEL 1 45865-417 TABLET 4 mg ORAL ANDA 12 sections
Methylprednisolone HUMAN PRESCRIPTION DRUG LABEL 1 49999-153 TABLET 4 mg ORAL NDA 14 sections
Medrol HUMAN PRESCRIPTION DRUG LABEL 1 50090-0092 TABLET 4 mg ORAL NDA 15 sections
Methylprednisolone HUMAN PRESCRIPTION DRUG LABEL 1 50090-3094 TABLET 4 mg ORAL ANDA 12 sections
methylprednisolone HUMAN PRESCRIPTION DRUG LABEL 1 50090-3811 TABLET 4 mg ORAL ANDA 12 sections
Methylprednisolone HUMAN PRESCRIPTION DRUG LABEL 1 50436-0001 TABLET 4 mg ORAL ANDA 12 sections
Methylprednisolone HUMAN PRESCRIPTION DRUG LABEL 1 50436-4037 TABLET 4 mg ORAL ANDA 12 sections
Methylprednisolone HUMAN PRESCRIPTION DRUG LABEL 1 53002-3120 TABLET 4 mg ORAL ANDA 12 sections
Methylprednisolone HUMAN PRESCRIPTION DRUG LABEL 1 54868-2913 TABLET 4 mg ORAL ANDA 11 sections
METHYLPREDNISOLONE HUMAN PRESCRIPTION DRUG LABEL 1 54868-6624 TABLET 4 mg ORAL ANDA 12 sections
MethylPREDNISolone HUMAN PRESCRIPTION DRUG LABEL 1 55045-1259 TABLET 4 mg ORAL ANDA 17 sections
MethylPREDNISolone HUMAN PRESCRIPTION DRUG LABEL 1 55289-649 TABLET 4 mg ORAL ANDA 13 sections
METHYLPREDNISOLONE HUMAN PRESCRIPTION DRUG LABEL 1 57582-101 TABLET 4 mg ORAL ANDA 16 sections
METHYLPREDNISOLONE HUMAN PRESCRIPTION DRUG LABEL 1 57582-101 TABLET 4 mg ORAL ANDA 16 sections