methylprednisolone Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
prednisone and prednisolone derivatives 1768 83-43-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • methylprednisolone
  • medralone
  • metilbetasone
A PREDNISOLONE derivative with similar anti-inflammatory action.
  • Molecular weight: 374.48
  • Formula: C22H30O5
  • CLOGP: 1.74
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 3
  • TPSA: 94.83
  • ALOGS: -3.54
  • ROTB: 2

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
7.50 mg O
20 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.32 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 4.90 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 11.14 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 82 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 1.20 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 6.10 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.23 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2.30 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Oct. 24, 1957 FDA PHARMACIA AND UPJOHN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Infusion related reaction 644.52 9.38 1111 137517 100097 46447337
Cytomegalovirus infection 635.32 9.38 485 138143 17659 46529775
Product use in unapproved indication 415.38 9.38 863 137765 89410 46458024
Completed suicide 375.34 9.38 13 138615 145907 46401527
Death 291.29 9.38 341 138287 335207 46212227
Transplant rejection 258.29 9.38 220 138408 9376 46538058
Posterior reversible encephalopathy syndrome 202.06 9.38 237 138391 14904 46532530
Aspergillus infection 199.98 9.38 165 138463 6725 46540709
Kidney transplant rejection 191.94 9.38 131 138497 3987 46543447
Polyomavirus-associated nephropathy 179.59 9.38 88 138540 1402 46546032
Toxicity to various agents 179.43 9.38 219 138409 211547 46335887
Urine abnormality 177.23 9.38 141 138487 5453 46541981
Haemophagocytic lymphohistiocytosis 167.07 9.38 162 138466 8180 46539254
Blood pressure fluctuation 163.80 9.38 311 138317 30137 46517297
Blood pressure diastolic abnormal 156.65 9.38 138 138490 6156 46541278
BK virus infection 150.55 9.38 98 138530 2751 46544683
Thrombotic microangiopathy 149.14 9.38 152 138476 8154 46539280
Red blood cells urine positive 148.46 9.38 94 138534 2513 46544921
Product dose omission issue 148.35 9.38 169 138459 168351 46379083
Mucormycosis 144.07 9.38 88 138540 2204 46545230
Multiple organ dysfunction syndrome 143.53 9.38 407 138221 51303 46496131
Oxygen saturation decreased 140.02 9.38 488 138140 68676 46478758
Complications of transplanted kidney 139.98 9.38 86 138542 2177 46545257
Bronchopulmonary aspergillosis 137.92 9.38 139 138489 7357 46540077
Fall 137.67 9.38 508 138120 328589 46218845
Pseudomonas infection 133.97 9.38 155 138473 9603 46537831
Lymphocyte count decreased 133.49 9.38 258 138370 25331 46522103
Nocardiosis 125.07 9.38 71 138557 1546 46545888
Urine leukocyte esterase positive 123.77 9.38 83 138545 2452 46544982
Blood pressure systolic abnormal 123.58 9.38 114 138514 5403 46542031
Pneumocystis jirovecii pneumonia 120.75 9.38 185 138443 15063 46532371
Urinary sediment present 119.86 9.38 72 138556 1748 46545686
Enterococcal infection 116.70 9.38 123 138505 6864 46540570
White blood cells urine positive 116.51 9.38 97 138531 4003 46543431
Delayed graft function 115.66 9.38 57 138571 920 46546514
Epstein-Barr virus infection 114.33 9.38 120 138508 6664 46540770
Intentional overdose 112.86 9.38 27 138601 64917 46482517
Klebsiella infection 112.56 9.38 118 138510 6544 46540890
Varicella zoster virus infection 110.30 9.38 75 138553 2268 46545166
Graft versus host disease 108.30 9.38 115 138513 6473 46540961
Cytomegalovirus infection reactivation 106.82 9.38 62 138566 1410 46546024
Throat irritation 106.45 9.38 253 138375 28648 46518786
Drug abuse 99.66 9.38 32 138596 63376 46484058
Injection site pain 99.17 9.38 103 138525 107049 46440385
Acinetobacter infection 98.20 9.38 58 138570 1364 46546070
Blood pressure increased 97.96 9.38 678 137950 125988 46421446
Crystal urine present 96.63 9.38 55 138573 1204 46546230
Infective aneurysm 94.94 9.38 39 138589 399 46547035
Cardiac failure congestive 93.32 9.38 81 138547 91669 46455765
Wrong technique in product usage process 91.90 9.38 24 138604 54398 46493036
Cytomegalovirus viraemia 91.62 9.38 88 138540 4390 46543044
Heart rate decreased 90.27 9.38 252 138376 31471 46515963
Nausea 87.22 9.38 1478 137150 685976 45861458
Off label use 86.39 9.38 1595 137033 378246 46169188
Encephalitis autoimmune 85.99 9.38 49 138579 1075 46546359
Glossodynia 84.22 9.38 15 138613 44358 46503076
Drug ineffective for unapproved indication 83.79 9.38 164 138464 16249 46531185
Reversible cerebral vasoconstriction syndrome 83.31 9.38 56 138572 1661 46545773
Post transplant lymphoproliferative disorder 83.13 9.38 78 138550 3778 46543656
Blood pressure diastolic decreased 81.21 9.38 149 138479 14062 46533372
Hospitalisation 80.34 9.38 44 138584 63341 46484093
Dehydration 79.22 9.38 228 138400 159312 46388122
Vomiting 79.20 9.38 912 137716 451882 46095552
Liver transplant rejection 79.09 9.38 50 138578 1333 46546101
Diarrhoea 78.94 9.38 1179 137449 558423 45989011
Lymphopenia 77.09 9.38 152 138476 15141 46532293
Septic shock 75.92 9.38 357 138271 57536 46489898
Overdose 75.63 9.38 116 138512 101863 46445571
Erythema 74.16 9.38 698 137930 142122 46405312
Viral haemorrhagic cystitis 73.27 9.38 36 138592 577 46546857
Respiratory failure 72.96 9.38 507 138121 94309 46453125
Acute graft versus host disease in intestine 72.15 9.38 51 138577 1644 46545790
Lupus nephritis 71.98 9.38 57 138571 2189 46545245
Confusional state 71.93 9.38 239 138389 159653 46387781
Alopecia 71.55 9.38 245 138383 162169 46385265
Electric shock 70.62 9.38 40 138588 867 46546567
Cytomegalovirus test positive 70.51 9.38 62 138566 2758 46544676
Cushingoid 70.49 9.38 90 138538 6176 46541258
Cytomegalovirus chorioretinitis 70.37 9.38 48 138580 1459 46545975
Device expulsion 68.89 9.38 3 138625 27539 46519895
Bacterial test 68.74 9.38 44 138584 1199 46546235
Abdominal discomfort 67.97 9.38 226 138402 150939 46396495
Acute graft versus host disease in skin 67.53 9.38 62 138566 2920 46544514
Pneumomediastinum 66.98 9.38 43 138585 1178 46546256
Blood urine present 66.71 9.38 126 138502 12156 46535278
Adenovirus infection 66.36 9.38 60 138568 2770 46544664
Steroid diabetes 66.17 9.38 34 138594 602 46546832
Human herpesvirus 6 infection 65.79 9.38 56 138572 2383 46545051
Suicide attempt 65.78 9.38 41 138587 54995 46492439
Progressive multifocal leukoencephalopathy 64.88 9.38 119 138509 11227 46536207
Immunosuppressant drug level increased 64.34 9.38 63 138565 3219 46544215
Chorioretinopathy 64.04 9.38 35 138593 706 46546728
Escherichia infection 63.82 9.38 115 138513 10702 46536732
Heart rate increased 63.59 9.38 410 138218 74381 46473053
Pyrexia 63.40 9.38 1417 137211 347385 46200049
Myopathy 62.37 9.38 102 138526 8779 46538655
Intervertebral discitis 61.84 9.38 55 138573 2484 46544950
Human herpesvirus 8 infection 61.81 9.38 23 138605 176 46547258
Urine ketone body present 61.54 9.38 51 138577 2091 46545343
Systemic candida 60.40 9.38 56 138572 2671 46544763
Disease recurrence 59.87 9.38 154 138474 18317 46529117
Inappropriate schedule of product administration 58.45 9.38 64 138564 64949 46482485
Blood pressure systolic increased 56.39 9.38 201 138427 28586 46518848
Dizziness 55.45 9.38 696 137932 339718 46207716
Candida infection 54.94 9.38 168 138460 22072 46525362
Drug resistance 54.44 9.38 143 138485 17225 46530209
Granulomatosis with polyangiitis 54.06 9.38 44 138584 1758 46545676
Graft versus host disease in gastrointestinal tract 53.86 9.38 51 138577 2499 46544935
Mycoplasma infection 53.69 9.38 26 138602 403 46547031
Pneumatosis intestinalis 53.62 9.38 46 138582 1979 46545455
Myocardial infarction 53.19 9.38 133 138495 97395 46450039
Injection site erythema 52.96 9.38 87 138541 74340 46473094
Pemphigus 52.37 9.38 35 138593 45239 46502195
Intentional product use issue 52.24 9.38 301 138327 52479 46494955
Red cell distribution width increased 52.11 9.38 87 138541 7617 46539817
Nephrotic syndrome 51.18 9.38 68 138560 4853 46542581
Product quality issue 50.91 9.38 21 138607 35627 46511807
Haemoglobin urine present 50.86 9.38 29 138599 637 46546797
Fatigue 50.17 9.38 1401 137227 607296 45940138
Constipation 49.61 9.38 308 138320 173789 46373645
Acute respiratory distress syndrome 49.02 9.38 160 138468 21762 46525672
Ureaplasma infection 48.99 9.38 25 138603 436 46546998
Osteonecrosis 48.93 9.38 178 138450 25566 46521868
Staphylococcal sepsis 48.22 9.38 83 138545 7449 46539985
Contraindicated product administered 47.62 9.38 104 138524 79843 46467591
Culture urine positive 46.77 9.38 54 138574 3337 46544097
Glomerulonephritis 46.33 9.38 38 138590 1535 46545899
Drug intolerance 46.25 9.38 252 138376 146797 46400637
Lymphocyte percentage decreased 45.94 9.38 48 138580 2651 46544783
Renal transplant failure 45.82 9.38 27 138601 632 46546802
Sepsis 45.56 9.38 610 138018 135404 46412030
Acute graft versus host disease 45.52 9.38 58 138570 3972 46543462
Leukopenia 45.43 9.38 353 138275 67990 46479444
Decreased appetite 45.41 9.38 363 138265 193473 46353961
Adverse drug reaction 45.29 9.38 39 138589 44323 46503111
Monocyte count increased 45.20 9.38 65 138563 4999 46542435
Demyelination 45.08 9.38 69 138559 5611 46541823
Pneumonia cytomegaloviral 44.87 9.38 41 138587 1919 46545515
Thrombocytopenia 44.61 9.38 573 138055 126008 46421426
Protein urine present 44.54 9.38 65 138563 5066 46542368
Mycobacterium abscessus infection 44.45 9.38 26 138602 600 46546834
Serotonin syndrome 44.23 9.38 9 138619 24211 46523223
Cerebrovascular accident 44.07 9.38 153 138475 100886 46446548
Psoriasis 43.79 9.38 106 138522 78498 46468936
Urine analysis abnormal 43.73 9.38 58 138570 4132 46543302
Brain abscess 43.47 9.38 38 138590 1677 46545757
Oedema peripheral 43.22 9.38 287 138341 159419 46388015
Pulmonary alveolar haemorrhage 42.50 9.38 57 138571 4105 46543329
International normalised ratio increased 42.31 9.38 46 138582 46837 46500597
Neutrophil count increased 42.30 9.38 115 138513 14138 46533296
Incorrect dose administered 41.87 9.38 44 138584 45506 46501928
Hyponatraemia 41.84 9.38 157 138471 101175 46446259
Immune thrombocytopenia 41.64 9.38 82 138546 8159 46539275
Adverse event 41.50 9.38 25 138603 34159 46513275
Central nervous system infection 41.25 9.38 25 138603 617 46546817
Blood pressure diastolic increased 41.12 9.38 68 138560 5906 46541528
Neutrophil percentage increased 40.83 9.38 45 138583 2642 46544792
Chronic allograft nephropathy 40.68 9.38 25 138603 633 46546801
Proteinuria 39.92 9.38 124 138504 16429 46531005
Loss of personal independence in daily activities 39.61 9.38 68 138560 57115 46490319
Febrile bone marrow aplasia 39.27 9.38 72 138556 6790 46540644
Hypoglycaemia 39.16 9.38 63 138565 54286 46493148
Cytomegalovirus colitis 39.15 9.38 36 138592 1699 46545735
Herpes simplex 39.10 9.38 74 138554 7149 46540285
Acute graft versus host disease in liver 38.77 9.38 24 138604 616 46546818
Disseminated intravascular coagulation 38.34 9.38 134 138494 18871 46528563
Accidental exposure to product 38.15 9.38 8 138620 21073 46526361
Polyomavirus viraemia 38.00 9.38 20 138608 373 46547061
Enterobacter infection 36.57 9.38 36 138592 1851 46545583
Plasma cell myeloma 36.54 9.38 47 138581 44431 46503003
Herpes virus infection 36.43 9.38 57 138571 4725 46542709
Status epilepticus 35.85 9.38 107 138521 13872 46533562
Symptom masked 35.77 9.38 22 138606 558 46546876
Feeding intolerance 35.74 9.38 21 138607 489 46546945
Bacterial test positive 35.55 9.38 54 138574 4362 46543072
Pleocytosis 35.43 9.38 21 138607 497 46546937
Cystitis haemorrhagic 35.34 9.38 48 138580 3499 46543935
Necrotising herpetic retinopathy 35.16 9.38 12 138616 69 46547365
Ear pruritus 34.83 9.38 37 138591 2083 46545351
Intentional product misuse 34.55 9.38 54 138574 47074 46500360
Depressed level of consciousness 34.40 9.38 55 138573 47514 46499920
Pedal pulse abnormal 34.36 9.38 14 138614 140 46547294
Cerebral aspergillosis 34.18 9.38 18 138610 336 46547098
Premature delivery 34.14 9.38 143 138485 21926 46525508
COVID-19 34.10 9.38 127 138501 18448 46528986
Swelling 34.05 9.38 223 138405 124288 46423146
Thunderclap headache 34.01 9.38 14 138614 144 46547290
Pharyngeal paraesthesia 33.91 9.38 28 138600 1142 46546292
Nephropathy toxic 33.90 9.38 71 138557 7383 46540051
Stenotrophomonas infection 33.45 9.38 32 138596 1588 46545846
Disseminated tuberculosis 33.30 9.38 41 138587 2711 46544723
Intentional self-injury 33.29 9.38 15 138613 24151 46523283
Graft versus host disease in skin 33.16 9.38 38 138590 2329 46545105
Immunodeficiency 32.37 9.38 99 138529 13007 46534427
Gastroenteritis norovirus 32.35 9.38 31 138597 1542 46545892
Hypogammaglobulinaemia 32.32 9.38 58 138570 5380 46542054
Atrial fibrillation 32.29 9.38 178 138450 103412 46444022
Adrenal insufficiency 32.28 9.38 99 138529 13025 46534409
Segmental diverticular colitis 31.91 9.38 13 138615 130 46547304
Listeriosis 31.86 9.38 27 138601 1142 46546292
Human bocavirus infection 31.78 9.38 17 138611 328 46547106
Necrotising retinitis 31.46 9.38 16 138612 277 46547157
Temperature regulation disorder 31.27 9.38 44 138584 3316 46544118
Drug ineffective 31.12 9.38 2374 136254 675464 45871970
Injection site bruising 31.02 9.38 36 138592 35600 46511834
Rheumatoid factor positive 30.97 9.38 11 138617 20450 46526984
Calcium ionised decreased 30.66 9.38 15 138613 238 46547196
COVID-19 pneumonia 30.65 9.38 43 138585 3232 46544202
Vasculitis 30.59 9.38 100 138528 13611 46533823
Encephalitis 30.50 9.38 68 138560 7380 46540054
Multiple sclerosis relapse 30.48 9.38 222 138406 41903 46505531
Opportunistic infection 30.30 9.38 31 138597 1670 46545764
Choroiditis 30.11 9.38 13 138615 152 46547282
Strongyloidiasis 29.99 9.38 23 138605 842 46546592
Product prescribing error 29.96 9.38 11 138617 20036 46527398
Laryngeal stenosis 29.92 9.38 21 138607 669 46546765
Malaise 29.88 9.38 752 137876 330480 46216954
Alveolitis 29.71 9.38 37 138591 2476 46544958
Diabetes mellitus 29.70 9.38 252 138376 49813 46497621
West Nile viral infection 29.63 9.38 17 138611 378 46547056
Knee arthroplasty 29.16 9.38 17 138611 23648 46523786
Rhodococcus infection 29.14 9.38 11 138617 88 46547346
JC virus infection 29.08 9.38 30 138598 1632 46545802
Intensive care unit acquired weakness 28.95 9.38 20 138608 621 46546813
Nitrite urine present 28.76 9.38 21 138607 713 46546721
Injection site reaction 28.69 9.38 62 138566 47787 46499647
Herpes zoster 28.62 9.38 318 138310 67554 46479880
Orthostatic hypotension 28.60 9.38 19 138609 24639 46522795
Systemic mycosis 28.54 9.38 23 138605 906 46546528
Accidental overdose 28.36 9.38 12 138616 20054 46527380
Blood thyroid stimulating hormone decreased 28.26 9.38 46 138582 3943 46543491
Transplant failure 28.25 9.38 26 138602 1228 46546206
Partial seizures 27.96 9.38 52 138576 4958 46542476
Specific gravity urine decreased 27.75 9.38 17 138611 428 46547006
Lung abscess 27.58 9.38 27 138601 1379 46546055
Hypokalaemia 27.57 9.38 151 138477 87873 46459561
Diffuse alveolar damage 27.35 9.38 21 138607 770 46546664
Proteus infection 27.27 9.38 22 138606 868 46546566
Weight increased 27.24 9.38 660 137968 163813 46383621
Cytomegalovirus enteritis 27.23 9.38 13 138615 195 46547239
Factor XIII deficiency 27.16 9.38 10 138618 74 46547360
Shock haemorrhagic 27.02 9.38 71 138557 8553 46538881
B-lymphocyte count decreased 26.91 9.38 21 138607 789 46546645
Mean cell haemoglobin decreased 26.91 9.38 38 138590 2874 46544560
Malacoplakia vesicae 26.78 9.38 9 138619 49 46547385
Discomfort 26.73 9.38 62 138566 46608 46500826
Malignant neoplasm progression 26.53 9.38 101 138527 64825 46482609
Post-traumatic stress disorder 26.43 9.38 45 138583 4003 46543431
Unresponsive to stimuli 26.42 9.38 34 138594 32140 46515294
Viraemia 26.39 9.38 23 138605 1011 46546423
Birdshot chorioretinopathy 26.38 9.38 10 138618 81 46547353
Feeling hot 26.37 9.38 198 138430 37730 46509704
C-reactive protein increased 26.32 9.38 278 138350 58312 46489122
Lethargy 26.20 9.38 72 138556 51099 46496335
Hypophagia 26.17 9.38 29 138599 29277 46518157
Injection site swelling 26.10 9.38 50 138578 40277 46507157
Bacteraemia 26.07 9.38 97 138531 14082 46533352
Dermatomyositis 25.91 9.38 31 138597 1990 46545444
Quadriparesis 25.87 9.38 29 138599 1735 46545699
Chronic graft versus host disease 25.83 9.38 36 138592 2689 46544745
IgA nephropathy 25.83 9.38 16 138612 411 46547023
Hallucination 25.78 9.38 70 138558 49881 46497553
Syncope 25.57 9.38 194 138434 104609 46442825
Band sensation 25.56 9.38 19 138609 663 46546771
Red blood cells urine 25.53 9.38 16 138612 420 46547014
Rhabdomyolysis 25.38 9.38 54 138574 41855 46505579
Anti-thyroid antibody positive 25.23 9.38 16 138612 429 46547005
Breast cancer metastatic 25.15 9.38 5 138623 13673 46533761
Malacoplakia gastrointestinal 25.12 9.38 9 138619 61 46547373
Infection reactivation 25.05 9.38 20 138608 777 46546657
Staphylococcal infection 25.01 9.38 187 138441 35584 46511850
Cerebral artery stenosis 24.98 9.38 15 138613 364 46547070
Renal tubular atrophy 24.97 9.38 17 138611 515 46546919
Anaemia 24.89 9.38 574 138054 255205 46292229
Rubella antibody positive 24.87 9.38 9 138619 63 46547371
Q fever 24.87 9.38 9 138619 63 46547371
Meningoencephalitis viral 24.61 9.38 14 138614 306 46547128
Ill-defined disorder 24.61 9.38 150 138478 26677 46520757
Gastroenteritis rotavirus 24.46 9.38 10 138618 101 46547333
Device malfunction 24.36 9.38 5 138623 13369 46534065
Oral herpes 24.26 9.38 118 138510 19272 46528162
Chorioretinitis 24.17 9.38 14 138614 317 46547117
Intestinal perforation 24.08 9.38 79 138549 10772 46536662
Therapeutic product effect incomplete 23.96 9.38 135 138493 78018 46469416
Red blood cell count increased 23.72 9.38 32 138596 2318 46545116
Bronchostenosis 23.56 9.38 14 138614 333 46547101
Sedation 23.55 9.38 20 138608 22890 46524544
Coronary artery disease 23.50 9.38 40 138588 33712 46513722
Injection site pruritus 23.41 9.38 52 138576 39691 46507743
Cytomegalovirus gastrointestinal infection 23.36 9.38 13 138615 272 46547162
Cardio-respiratory arrest 23.27 9.38 95 138533 59774 46487660
CSF protein increased 23.27 9.38 16 138612 493 46546941
Muir-Torre syndrome 23.19 9.38 7 138621 25 46547409
Kaposi's sarcoma 23.16 9.38 11 138617 163 46547271
Tuberculosis gastrointestinal 23.01 9.38 14 138614 348 46547086
Arthropathy 23.00 9.38 152 138476 84548 46462886
Urinary tract infection bacterial 22.96 9.38 43 138585 4122 46543312
Flushing 22.95 9.38 293 138335 64321 46483113
Encephalitis cytomegalovirus 22.90 9.38 16 138612 506 46546928
Epstein-Barr virus associated lymphoproliferative disorder 22.87 9.38 25 138603 1454 46545980
Chronic graft versus host disease in liver 22.86 9.38 11 138617 168 46547266
Wound 22.84 9.38 59 138569 42743 46504691
Hepatic necrosis 22.78 9.38 51 138577 5550 46541884
Pyomyositis 22.76 9.38 14 138614 355 46547079
Hyperammonaemia 22.72 9.38 46 138582 4670 46542764
Blood glucose decreased 22.67 9.38 14 138614 18878 46528556
Blood potassium increased 22.65 9.38 11 138617 16956 46530478
Pain 22.60 9.38 1172 137456 475776 46071658
Chronic graft versus host disease in skin 22.58 9.38 17 138611 605 46546829
Pneumocystis jirovecii infection 22.56 9.38 23 138605 1234 46546200
Hypertension 22.51 9.38 752 137876 195604 46351830
Pyelonephritis fungal 22.50 9.38 10 138618 126 46547308
Gastropleural fistula 22.49 9.38 8 138620 53 46547381
Device dislocation 22.45 9.38 19 138609 21783 46525651
Sense of oppression 22.36 9.38 21 138607 1018 46546416
Immunosuppressant drug level decreased 22.33 9.38 20 138608 912 46546522
Pneumonia klebsiella 22.26 9.38 29 138599 2030 46545404
Therapy non-responder 22.26 9.38 203 138425 40949 46506485
Complication associated with device 22.20 9.38 9 138619 15432 46532002
Smear cervix abnormal 22.02 9.38 32 138596 2484 46544950
Blood brain barrier defect 22 9.38 9 138619 91 46547343
CSF measles antibody positive 21.99 9.38 8 138620 57 46547377
Focal segmental glomerulosclerosis 21.94 9.38 24 138604 1397 46546037
Cytomegalovirus enterocolitis 21.94 9.38 16 138612 542 46546892
Hypofibrinogenaemia 21.84 9.38 21 138607 1049 46546385
Asthenia 21.80 9.38 731 137897 310344 46237090
Peripheral swelling 21.79 9.38 334 138294 157737 46389697
Biloma 21.75 9.38 8 138620 59 46547375
Loss of consciousness 21.65 9.38 211 138417 108027 46439407
Leukoencephalopathy 21.65 9.38 41 138587 3963 46543471
Irritable bowel syndrome 21.60 9.38 11 138617 16504 46530930
Thyroxine free increased 21.59 9.38 18 138610 744 46546690
Hyperglycaemia 21.58 9.38 178 138450 34893 46512541
Disseminated varicella zoster vaccine virus infection 21.52 9.38 8 138620 61 46547373
Hepatitis B 21.45 9.38 39 138589 3654 46543780
Allergy test positive 21.44 9.38 13 138615 321 46547113
Perinephric abscess 21.43 9.38 10 138618 142 46547292
Glomerulosclerosis 21.41 9.38 13 138615 322 46547112
Memory impairment 21.39 9.38 138 138490 77199 46470235
C-reactive protein abnormal 21.34 9.38 19 138609 21251 46526183
Pulmonary nocardiosis 21.33 9.38 9 138619 99 46547335
Central nervous system viral infection 21.33 9.38 9 138619 99 46547335
Tuberculosis 21.24 9.38 73 138555 10192 46537242
Escherichia sepsis 21.21 9.38 42 138586 4196 46543238
Pathogen resistance 21.18 9.38 52 138576 6008 46541426
Autoimmune hepatitis 21.17 9.38 61 138567 7753 46539681
Klebsiella test positive 21.17 9.38 20 138608 977 46546457
Nasopharyngitis 21.16 9.38 603 138025 153395 46394039
Escherichia urinary tract infection 21.00 9.38 73 138555 10250 46537184
Respiratory rate increased 20.84 9.38 78 138550 11355 46536079
Pulmonary haemorrhage 20.84 9.38 54 138574 6451 46540983
Intra-abdominal pressure increased 20.71 9.38 11 138617 209 46547225
Liver abscess 20.68 9.38 32 138596 2627 46544807
Meningoencephalitis bacterial 20.57 9.38 8 138620 70 46547364
Feeling abnormal 20.55 9.38 255 138373 124805 46422629
Joint tuberculosis 20.49 9.38 9 138619 110 46547324
Pulmonary hypertension 20.47 9.38 48 138580 35945 46511489
Gastrooesophageal reflux disease 20.39 9.38 133 138495 74211 46473223
Serratia infection 20.32 9.38 17 138611 706 46546728
Gastrointestinal mucormycosis 20.31 9.38 10 138618 161 46547273
Pulmonary tuberculosis 20.29 9.38 44 138584 4687 46542747
Urinary tract candidiasis 20.27 9.38 15 138613 520 46546914
Myelitis 20.26 9.38 21 138607 1149 46546285
Central nervous system vasculitis 20.17 9.38 19 138609 925 46546509
Rebound effect 20.07 9.38 32 138596 2695 46544739
Unevaluable event 20.07 9.38 70 138558 46105 46501329
Graft versus host disease in liver 20.00 9.38 14 138614 444 46546990
Drug level decreased 19.89 9.38 50 138578 5862 46541572
Mean cell volume decreased 19.87 9.38 30 138598 2410 46545024
Hepatic cyst infection 19.80 9.38 9 138619 120 46547314
Infective pulmonary exacerbation of cystic fibrosis 19.76 9.38 4 138624 10803 46536631
Graft loss 19.69 9.38 13 138615 374 46547060
Blood calcium decreased 19.68 9.38 11 138617 15662 46531772
Candida sepsis 19.61 9.38 22 138606 1317 46546117
Allergy to plants 19.61 9.38 15 138613 547 46546887
Meningitis chemical 19.60 9.38 9 138619 123 46547311
Neuropsychiatric lupus 19.60 9.38 9 138619 123 46547311
Therapeutic response decreased 19.50 9.38 205 138423 42940 46504494
Transient ischaemic attack 19.49 9.38 47 138581 34856 46512578
Secondary immunodeficiency 19.45 9.38 19 138609 968 46546466
Drug interaction 19.40 9.38 457 138171 202637 46344797
Aeromonas infection 19.37 9.38 8 138620 83 46547351
Hairy cell leukaemia 19.35 9.38 6 138622 24 46547410
Pneumonia lipoid 19.28 9.38 9 138619 128 46547306
Haemolytic uraemic syndrome 19.20 9.38 30 138598 2484 46544950
Biliary anastomosis complication 19.16 9.38 6 138622 25 46547409
Product use issue 19.14 9.38 184 138444 94460 46452974
Swollen tongue 19.13 9.38 36 138592 29196 46518238
Optic neuritis 18.97 9.38 54 138574 6817 46540617
Corynebacterium infection 18.95 9.38 13 138615 399 46547035
Pyelonephritis 18.89 9.38 93 138535 15264 46532170
Pulmonary mucormycosis 18.88 9.38 8 138620 89 46547345
Anal erythema 18.88 9.38 10 138618 189 46547245
Immune effector cell-associated neurotoxicity syndrome 18.85 9.38 16 138612 678 46546756
Poisoning 18.79 9.38 9 138619 13985 46533449
Evans syndrome 18.74 9.38 10 138618 192 46547242
Full blood count decreased 18.73 9.38 23 138605 22188 46525246
Device issue 18.70 9.38 19 138609 19961 46527473
Dyskinesia 18.60 9.38 36 138592 28889 46518545
Urticaria 18.59 9.38 470 138158 117422 46430012
Interleukin level increased 18.57 9.38 11 138617 260 46547174
Cerebral venous thrombosis 18.54 9.38 27 138601 2100 46545334
Lip pruritus 18.51 9.38 14 138614 502 46546932
Bone pain 18.47 9.38 74 138554 46816 46500618
Pancytopenia 18.46 9.38 355 138273 84703 46462731
Pneumatosis 18.45 9.38 13 138615 417 46547017
Sebaceous carcinoma 18.44 9.38 6 138622 29 46547405
Substance-induced psychotic disorder 18.37 9.38 23 138605 1547 46545887
Pain in jaw 18.17 9.38 56 138572 38316 46509118
Globulins decreased 18.15 9.38 10 138618 205 46547229
Serum sickness 18.13 9.38 29 138599 2449 46544985
Staphylococcal bacteraemia 18.13 9.38 43 138585 4861 46542573
Quadriplegia 18.06 9.38 24 138604 1713 46545721
Synovitis 17.92 9.38 107 138521 60968 46486466
Cryptococcosis 17.92 9.38 17 138611 835 46546599
Penicillium infection 17.84 9.38 8 138620 103 46547331
Hepatitis toxic 17.83 9.38 32 138596 2968 46544466
Pulmonary arterial hypertension 17.80 9.38 31 138597 25897 46521537
Visceral leishmaniasis 17.76 9.38 13 138615 443 46546991
Thrombosis 17.65 9.38 96 138532 55973 46491461
Oral pain 17.62 9.38 29 138599 24768 46522666
Chest pain 17.61 9.38 394 138234 175930 46371504
Eye infection toxoplasmal 17.61 9.38 11 138617 287 46547147
Creatinine urine decreased 17.58 9.38 9 138619 158 46547276
Renal artery stenosis 17.52 9.38 24 138604 1764 46545670
Organic brain syndrome 17.48 9.38 9 138619 160 46547274
Multiple-drug resistance 17.39 9.38 29 138599 2536 46544898
Glomerulonephritis chronic 17.38 9.38 9 138619 162 46547272
Pain in extremity 17.38 9.38 611 138017 258069 46289365
Toxic neuropathy 17.33 9.38 12 138616 374 46547060
Tri-iodothyronine free decreased 17.32 9.38 10 138618 225 46547209
Pregnancy 17.25 9.38 34 138594 27103 46520331
Nasal septum disorder 17.25 9.38 8 138620 112 46547322
Haemoglobin urine 17.25 9.38 8 138620 112 46547322
Blood creatinine decreased 17.12 9.38 41 138587 4663 46542771
Fusarium infection 17.10 9.38 14 138614 564 46546870
Mental status changes 17.05 9.38 57 138571 38031 46509403
Haemolytic anaemia 17.00 9.38 66 138562 9776 46537658
Fungaemia 16.96 9.38 25 138603 1966 46545468
Orbital apex syndrome 16.96 9.38 6 138622 39 46547395
Seizure 16.96 9.38 260 138368 122794 46424640
Product substitution issue 16.87 9.38 12 138616 15019 46532415
Urinary casts 16.81 9.38 13 138615 482 46546952
Monocyte percentage increased 16.78 9.38 18 138610 1025 46546409
Asymptomatic bacteriuria 16.75 9.38 7 138621 75 46547359
Pneumonia acinetobacter 16.75 9.38 5 138623 17 46547417
Product storage error 16.75 9.38 7 138621 11785 46535649
Haematemesis 16.71 9.38 38 138590 28768 46518666
Transient hypogammaglobulinaemia of infancy 16.71 9.38 6 138622 41 46547393
Hand deformity 16.70 9.38 50 138578 34524 46512910
Large intestine perforation 16.65 9.38 55 138573 7525 46539909
Cerebellar stroke 16.63 9.38 9 138619 178 46547256
Cataract 16.58 9.38 207 138421 45208 46502226
Lichen sclerosus 16.55 9.38 17 138611 920 46546514
Haemorrhagic varicella syndrome 16.53 9.38 4 138624 4 46547430
Blood immunoglobulin M decreased 16.52 9.38 15 138613 696 46546738
Foetal exposure during delivery 16.46 9.38 6 138622 43 46547391
Graft versus host disease in lung 16.46 9.38 11 138617 323 46547111
Osteonecrosis of jaw 16.44 9.38 50 138578 34352 46513082
Suicidal ideation 16.42 9.38 99 138529 56283 46491151
Listeria encephalitis 16.40 9.38 9 138619 183 46547251
Leukocyturia 16.39 9.38 17 138611 931 46546503
Ultrasound ovary abnormal 16.35 9.38 7 138621 80 46547354
Ureteral disorder 16.28 9.38 10 138618 253 46547181
Epstein-Barr virus infection reactivation 16.18 9.38 10 138618 256 46547178
Monocyte percentage decreased 16.13 9.38 8 138620 131 46547303
Electrocardiogram QT prolonged 16.09 9.38 88 138540 51237 46496197
Malacoplakia 16.05 9.38 7 138621 84 46547350
Capillaritis 16.05 9.38 7 138621 84 46547350
Torsade de pointes 16.04 9.38 8 138620 12146 46535288
Obstructive airways disorder 16.01 9.38 10 138618 13402 46534032
Scleroderma renal crisis 16.00 9.38 10 138618 261 46547173
Sputum discoloured 16.00 9.38 9 138619 12769 46534665
Urine oxalate increased 15.98 9.38 9 138619 193 46547241
Meningomyelitis herpes 15.93 9.38 5 138623 21 46547413
Clostridium difficile colitis 15.93 9.38 102 138526 18451 46528983
Bronchiolitis obliterans syndrome 15.91 9.38 7 138621 86 46547348
Injection site haemorrhage 15.88 9.38 23 138605 20686 46526748
Intestine transplant rejection 15.79 9.38 6 138622 49 46547385
Hepatitis acute 15.78 9.38 57 138571 8157 46539277
Central nervous system lymphoma 15.69 9.38 19 138609 1235 46546199
Endocrine ophthalmopathy 15.67 9.38 10 138618 271 46547163
Aphthous ulcer 15.66 9.38 63 138565 9485 46537949
Temperature intolerance 15.66 9.38 54 138574 7553 46539881
Band neutrophil percentage increased 15.65 9.38 9 138619 201 46547233
Leukocytosis 15.62 9.38 121 138507 23277 46524157
Vaginal haemorrhage 15.49 9.38 33 138595 25571 46521863
Cestode infection 15.48 9.38 10 138618 277 46547157
Pneumocephalus 15.45 9.38 8 138620 144 46547290
Pseudomonal sepsis 15.44 9.38 24 138604 1978 46545456
Ovarian fibroma 15.42 9.38 7 138621 93 46547341
Seroconversion test positive 15.39 9.38 5 138623 24 46547410
Low birth weight baby 15.29 9.38 43 138585 5391 46542043
Blood immunoglobulin G decreased 15.26 9.38 23 138605 1845 46545589
Premenstrual syndrome 15.25 9.38 14 138614 659 46546775
Type I hypersensitivity 15.21 9.38 26 138602 2320 46545114
Drug-induced liver injury 15.20 9.38 128 138500 25240 46522194
Red blood cell sedimentation rate abnormal 15.19 9.38 11 138617 13638 46533796
Drug withdrawal syndrome 15.19 9.38 37 138591 27347 46520087
Infected varicose vein 15.07 9.38 5 138623 26 46547408
Polyglandular disorder 15.07 9.38 5 138623 26 46547408
Stomatitis 15.01 9.38 130 138498 68167 46479267
Joint effusion 15.01 9.38 73 138555 11922 46535512
Food allergy 14.96 9.38 50 138578 6883 46540551
Dyspnoea 14.95 9.38 1323 137305 514225 46033209
Abscess 14.92 9.38 81 138547 13808 46533626
Fungal skin infection 14.88 9.38 33 138595 3569 46543865
Bone marrow failure 14.87 9.38 144 138484 29525 46517909
Metastases to bone 14.84 9.38 18 138610 17458 46529976
Germ cell cancer 14.81 9.38 6 138622 59 46547375
Influenza like illness 14.79 9.38 105 138523 57465 46489969
Meningitis listeria 14.77 9.38 11 138617 385 46547049
Nail bed inflammation 14.77 9.38 11 138617 385 46547049
Abnormal dreams 14.76 9.38 6 138622 10273 46537161
Mycobacterial infection 14.63 9.38 21 138607 1612 46545822
Nosocomial infection 14.61 9.38 21 138607 1614 46545820
Psoriatic arthropathy 14.59 9.38 57 138571 36322 46511112
Ulcer 14.55 9.38 95 138533 17297 46530137
Adjusted calcium decreased 14.54 9.38 7 138621 107 46547327
Myelocyte percentage increased 14.52 9.38 8 138620 164 46547270
Type IIb hyperlipidaemia 14.47 9.38 5 138623 30 46547404
Microsporidia infection 14.43 9.38 9 138619 234 46547200
Erythrosis 14.38 9.38 6 138622 64 46547370
Osteoporosis 14.36 9.38 184 138444 40424 46507010
Coronavirus infection 14.36 9.38 28 138600 2766 46544668
Hepatic artery aneurysm 14.31 9.38 4 138624 10 46547424
Complications of transplanted liver 14.29 9.38 11 138617 405 46547029
Thyroid stimulating immunoglobulin increased 14.26 9.38 7 138621 112 46547322
Blood beta-D-glucan increased 14.23 9.38 9 138619 240 46547194
Respiratory arrest 14.20 9.38 52 138576 33764 46513670
Injection site warmth 14.18 9.38 12 138616 13760 46533674
Abortion spontaneous 14.14 9.38 74 138554 43572 46503862
Body temperature increased 14.14 9.38 124 138504 24737 46522697
Gait disturbance 14.10 9.38 326 138302 144937 46402497
Hypoproteinaemia 14.08 9.38 22 138606 1821 46545613
Acute kidney injury 14.08 9.38 565 138063 235290 46312144
Fibromyalgia 14.08 9.38 58 138570 36405 46511029
Schizophrenia 14.04 9.38 4 138624 8564 46538870
Mucocutaneous leishmaniasis 14.02 9.38 10 138618 327 46547107
Blood loss anaemia 14.02 9.38 4 138624 8553 46538881
Aplasia 13.92 9.38 32 138596 3544 46543890
Product dispensing error 13.91 9.38 5 138623 9228 46538206
Band neutrophil count increased 13.89 9.38 10 138618 332 46547102
Cardiac disorder 13.86 9.38 75 138553 43783 46503651
Refractory anaemia with an excess of blasts 13.85 9.38 11 138617 424 46547010
Cutaneous lupus erythematosus 13.80 9.38 26 138602 2503 46544931
Underdose 13.78 9.38 23 138605 19535 46527899
Mean cell haemoglobin concentration decreased 13.72 9.38 26 138602 2514 46544920
Product contamination 13.66 9.38 12 138616 533 46546901
Myelopathy 13.63 9.38 26 138602 2526 46544908
Monocyte count decreased 13.46 9.38 21 138607 1736 46545698
Pneumonia bacterial 13.44 9.38 48 138580 6831 46540603
Enterococcus test positive 13.40 9.38 16 138612 1025 46546409
Tardive dyskinesia 13.37 9.38 3 138625 7540 46539894
Moraxella infection 13.35 9.38 10 138618 353 46547081
Sensory loss 13.35 9.38 48 138580 6854 46540580
Anxiety 13.33 9.38 425 138203 181532 46365902
Coagulation factor VIII level increased 13.32 9.38 4 138624 14 46547420
Occult blood 13.28 9.38 15 138613 905 46546529
Microangiopathic haemolytic anaemia 13.27 9.38 11 138617 451 46546983
Paraparesis 13.25 9.38 22 138606 1917 46545517
Oropharyngeal plaque 13.24 9.38 9 138619 272 46547162
Inflammatory marker increased 13.19 9.38 41 138587 5434 46542000
Hepatic haemorrhage 13.17 9.38 11 138617 456 46546978
Product complaint 13.14 9.38 10 138618 12091 46535343
Urine leukocyte esterase 13.14 9.38 7 138621 134 46547300
Engraftment syndrome 13.12 9.38 9 138619 276 46547158
Diabetic macroangiopathy 13.09 9.38 7 138621 135 46547299
Enteritis 13.08 9.38 47 138581 6708 46540726
Specific gravity urine increased 13.07 9.38 8 138620 201 46547233
Spinal cord paralysis 13.03 9.38 5 138623 42 46547392
Arthralgia 13.01 9.38 1254 137374 363349 46184085
Candida test positive 12.98 9.38 15 138613 928 46546506
Treatment noncompliance 12.97 9.38 45 138583 29686 46517748
Body temperature decreased 12.95 9.38 76 138552 13333 46534101
Coloboma 12.94 9.38 6 138622 84 46547350
Endometrial ablation 12.91 9.38 13 138615 687 46546747
Bacterial sepsis 12.89 9.38 31 138597 3536 46543898
Monoparesis 12.87 9.38 19 138609 1496 46545938
Hallucination, auditory 12.87 9.38 8 138620 10748 46536686
Low cardiac output syndrome 12.84 9.38 9 138619 286 46547148
Moyamoya disease 12.83 9.38 5 138623 44 46547390
Lip swelling 12.80 9.38 36 138592 25359 46522075
Skin striae 12.77 9.38 16 138612 1077 46546357
Incorrect route of product administration 12.76 9.38 18 138610 16365 46531069
Carcinoma in situ 12.75 9.38 6 138622 87 46547347
Atypical haemolytic uraemic syndrome 12.75 9.38 11 138617 477 46546957
Steroid withdrawal syndrome 12.69 9.38 11 138617 480 46546954
Faecal volume decreased 12.69 9.38 7 138621 144 46547290
Bile duct stenosis 12.68 9.38 16 138612 1085 46546349
Escherichia pyelonephritis 12.67 9.38 10 138618 382 46547052
Dystonia 12.62 9.38 9 138619 11248 46536186
Acarodermatitis 12.61 9.38 13 138615 707 46546727
Hepatic infarction 12.60 9.38 12 138616 592 46546842
Neoplasm progression 12.59 9.38 39 138589 26644 46520790
Herpes simplex encephalitis 12.57 9.38 9 138619 296 46547138
Cryptococcal fungaemia 12.54 9.38 5 138623 47 46547387
Varicella 12.53 9.38 20 138608 1686 46545748
Therapy cessation 12.51 9.38 39 138589 26590 46520844
Diverticulum 12.51 9.38 9 138619 11197 46536237
Ecthyma 12.50 9.38 8 138620 218 46547216
Irritability 12.50 9.38 44 138584 28902 46518532
Beta 2 microglobulin increased 12.43 9.38 7 138621 150 46547284
Renal tubular necrosis 12.42 9.38 64 138564 10695 46536739
Pyonephrosis 12.40 9.38 3 138625 3 46547431
Fear 12.36 9.38 18 138610 16154 46531280
Palmar erythema 12.34 9.38 18 138610 1402 46546032
Chronic kidney disease 12.31 9.38 71 138557 40800 46506634
Fungal infection 12.29 9.38 138 138490 29382 46518052
Kidney fibrosis 12.29 9.38 18 138610 1407 46546027
Thyroid stimulating immunoglobulin 12.27 9.38 5 138623 50 46547384
Ureteric stenosis 12.26 9.38 12 138616 613 46546821
Breast cancer 12.19 9.38 82 138546 45436 46501998
Sleep disorder 12.19 9.38 85 138543 46710 46500724
Hyperpyrexia 12.18 9.38 26 138602 2740 46544694
Pseudomonal bacteraemia 12.16 9.38 17 138611 1274 46546160
Enterocolitis viral 12.09 9.38 8 138620 231 46547203
Bacterial infection 12.04 9.38 86 138542 16130 46531304
Cytomegalovirus hepatitis 12.04 9.38 9 138619 317 46547117
Ophthalmoplegia 12.04 9.38 14 138614 872 46546562
Polychondritis 12.02 9.38 10 138618 412 46547022
Cryptococcal cutaneous infection 12.01 9.38 5 138623 53 46547381
Anti-neutrophil cytoplasmic antibody positive vasculitis 11.96 9.38 21 138607 1914 46545520
Osteoarthritis 11.94 9.38 122 138506 61903 46485531
Erectile dysfunction 11.94 9.38 3 138625 4 46547430
Mycoplasma test positive 11.93 9.38 5 138623 54 46547380
Tubulointerstitial nephritis 11.91 9.38 80 138548 14708 46532726
Trichodysplasia spinulosa 11.88 9.38 10 138618 419 46547015
Haemostasis 11.88 9.38 8 138620 238 46547196
Tendon rupture 11.78 9.38 50 138578 7709 46539725
Gamma-glutamyltransferase increased 11.72 9.38 145 138483 31595 46515839
Chest discomfort 11.71 9.38 351 138277 89918 46457516
Blood count abnormal 11.71 9.38 22 138606 17856 46529578
Alopecia scarring 11.69 9.38 6 138622 106 46547328
Aspergilloma 11.69 9.38 7 138621 169 46547265
Pterygium 11.69 9.38 7 138621 169 46547265
Contusion 11.66 9.38 186 138442 87301 46460133
Normochromic anaemia 11.65 9.38 8 138620 246 46547188
Meningitis cryptococcal 11.65 9.38 16 138612 1179 46546255
Waxy flexibility 11.64 9.38 6 138622 107 46547327
Peritonitis 11.62 9.38 103 138525 20611 46526823
Ureteral necrosis 11.62 9.38 5 138623 58 46547376
Passenger lymphocyte syndrome 11.62 9.38 5 138623 58 46547376
Nodal osteoarthritis 11.55 9.38 13 138615 781 46546653
Coma 11.55 9.38 114 138514 58235 46489199
Mucous stools 11.55 9.38 24 138604 2481 46544953
Hepatic cirrhosis 11.55 9.38 18 138610 15714 46531720
Reticulocytosis 11.54 9.38 6 138622 109 46547325
Immature granulocyte count increased 11.51 9.38 8 138620 251 46547183
Erythema migrans 11.44 9.38 4 138624 25 46547409
Vasculitis necrotising 11.43 9.38 11 138617 550 46546884
Magnesium deficiency 11.43 9.38 10 138618 442 46546992
Mean cell haemoglobin concentration increased 11.41 9.38 10 138618 443 46546991
Product administration error 11.39 9.38 26 138602 19655 46527779
Hypertrichosis 11.37 9.38 14 138614 926 46546508
Neurological decompensation 11.35 9.38 20 138608 1828 46545606
Complications of transplant surgery 11.33 9.38 7 138621 179 46547255
Hypertriglyceridaemia 11.31 9.38 40 138588 5664 46541770
Salmonella test positive 11.31 9.38 4 138624 26 46547408
Skin fissures 11.29 9.38 49 138579 7631 46539803
Renal impairment 11.27 9.38 295 138333 74077 46473357
Nightmare 11.25 9.38 20 138608 16578 46530856
Interleukin-2 receptor increased 11.25 9.38 5 138623 63 46547371
Intestinal infarction 11.24 9.38 14 138614 937 46546497
Hepatic enzyme abnormal 11.24 9.38 33 138595 4239 46543195
Paradoxical drug reaction 11.24 9.38 23 138605 2353 46545081
Cytokine storm 11.23 9.38 8 138620 261 46547173
Metastases to liver 11.23 9.38 26 138602 19559 46527875
Transplant dysfunction 11.22 9.38 35 138593 4647 46542787
Pyometra 11.21 9.38 6 138622 116 46547318
Coordination abnormal 11.19 9.38 63 138565 10886 46536548
Growth retardation 11.19 9.38 14 138614 941 46546493
Hepatic artery thrombosis 11.18 9.38 5 138623 64 46547370
Helicobacter infection 11.17 9.38 11 138617 11725 46535709
White blood cell count increased 11.16 9.38 189 138439 44030 46503404
Acute respiratory failure 11.15 9.38 134 138494 29004 46518430
Immunosuppression 11.13 9.38 48 138580 7452 46539982
Neuromyelitis optica spectrum disorder 11.11 9.38 13 138615 815 46546619
Flatulence 11.11 9.38 46 138582 28832 46518602
Morganella infection 11.09 9.38 10 138618 460 46546974
Tremor 11.08 9.38 260 138368 115379 46432055
T-lymphocyte count decreased 11.07 9.38 8 138620 267 46547167
Hemivertebra 11.07 9.38 6 138622 119 46547315
Nose deformity 11.02 9.38 6 138622 120 46547314
Blood lactate dehydrogenase increased 11.02 9.38 101 138527 20399 46527035
Autoimmune thyroiditis 11.02 9.38 26 138602 2929 46544505
Tri-iodothyronine free increased 10.99 9.38 7 138621 189 46547245
Lymphocele 10.98 9.38 13 138615 825 46546609
Mycobacterium kansasii infection 10.98 9.38 6 138622 121 46547313
Cytokine release syndrome 10.97 9.38 42 138586 6181 46541253
Systemic inflammatory response syndrome 10.94 9.38 38 138590 5333 46542101
Head injury 10.94 9.38 37 138591 24599 46522835
Cancer in remission 10.94 9.38 4 138624 29 46547405
Encephalitis Japanese B 10.94 9.38 4 138624 29 46547405
Creatinine urine increased 10.93 9.38 7 138621 191 46547243
Thrombocytopenic purpura 10.91 9.38 16 138612 1252 46546182
Genital herpes 10.90 9.38 18 138610 1561 46545873
Retinal depigmentation 10.89 9.38 8 138620 274 46547160
Prescribed overdose 10.89 9.38 9 138619 10440 46536994
Human herpes virus 8 test positive 10.88 9.38 3 138625 7 46547427
Neurosarcoidosis 10.86 9.38 7 138621 193 46547241
Paralysis 10.86 9.38 53 138575 8668 46538766
Vascular rupture 10.86 9.38 16 138612 1258 46546176
Abdominal distension 10.79 9.38 153 138475 73198 46474236
Skin infection 10.78 9.38 64 138564 11275 46536159
Porphyria acute 10.78 9.38 9 138619 373 46547061
Microscopic polyangiitis 10.76 9.38 6 138622 126 46547308
Impaired work ability 10.74 9.38 13 138615 12623 46534811
Angina pectoris 10.71 9.38 42 138586 26733 46520701
Pneumonia pseudomonal 10.69 9.38 21 138607 2085 46545349
Eosinophil percentage increased 10.67 9.38 13 138615 850 46546584
Vesicoureteric reflux 10.64 9.38 7 138621 200 46547234
Epstein-Barr viraemia 10.61 9.38 12 138616 725 46546709
B-lymphocyte count increased 10.60 9.38 6 138622 130 46547304
Acute disseminated encephalomyelitis 10.55 9.38 7 138621 203 46547231
Oedema 10.55 9.38 138 138490 66933 46480501
Mobility decreased 10.54 9.38 122 138506 60472 46486962
Hepatocellular injury 10.53 9.38 134 138494 29388 46518046
Muscle hypertrophy 10.53 9.38 5 138623 74 46547360
Post procedural bile leak 10.51 9.38 6 138622 132 46547302
Tachycardia 10.51 9.38 378 138250 99244 46448190
Foetal growth restriction 10.51 9.38 43 138585 6524 46540910
Acute myocardial infarction 10.41 9.38 54 138574 31870 46515564
Wound infection bacterial 10.40 9.38 9 138619 392 46547042
Calcification of muscle 10.39 9.38 4 138624 34 46547400
Right ventricular failure 10.37 9.38 20 138608 16073 46531361
Visual tracking test abnormal 10.34 9.38 3 138625 9 46547425
Myocardiac abscess 10.34 9.38 3 138625 9 46547425
Herpes simplex oesophagitis 10.32 9.38 6 138622 137 46547297
Therapy partial responder 10.31 9.38 34 138594 4648 46542786
Injection site mass 10.31 9.38 18 138610 15022 46532412
Incorrect product administration duration 10.29 9.38 8 138620 9569 46537865
Dyschromatopsia 10.29 9.38 8 138620 299 46547135
Lower limb fracture 10.28 9.38 13 138615 12385 46535049
Arrhythmia 10.24 9.38 61 138567 34780 46512654
Somnolence 10.20 9.38 371 138257 156150 46391284
Lung transplant rejection 10.19 9.38 12 138616 757 46546677
Amnesia 10.18 9.38 77 138551 41554 46505880
Encephalopathy 10.16 9.38 148 138480 33441 46513993
Atypical mycobacterial infection 10.12 9.38 13 138615 897 46546537
Nitrite urine 10.10 9.38 3 138625 10 46547424
Mean arterial pressure increased 10.10 9.38 3 138625 10 46547424
Plasma cells decreased 10.09 9.38 4 138624 37 46547397
Salivary gland mass 10.07 9.38 5 138623 82 46547352
Inflammatory pain 10.06 9.38 11 138617 640 46546794
Pneumothorax spontaneous 10.05 9.38 10 138618 521 46546913
Bradyphrenia 10.04 9.38 3 138625 6227 46541207
Crystalluria 10.04 9.38 9 138619 411 46547023
Pneumonia legionella 10.01 9.38 16 138612 1351 46546083
Coeliac disease 10.00 9.38 45 138583 7116 46540318
Interstitial lung disease 10 9.38 220 138408 53729 46493705
Poor venous access 10.00 9.38 50 138578 8258 46539176
Peripheral sensorimotor neuropathy 9.96 9.38 15 138613 1203 46546231
Paraspinal abscess 9.91 9.38 4 138624 39 46547395
Crying 9.91 9.38 31 138597 21110 46526324
Central venous pressure increased 9.86 9.38 5 138623 86 46547348
Bacteroides infection 9.86 9.38 5 138623 86 46547348
Aspergillus test positive 9.84 9.38 8 138620 319 46547115
Atrioventricular septal defect 9.84 9.38 7 138621 228 46547206
Menstruation irregular 9.82 9.38 42 138586 6497 46540937
Endocarditis 9.82 9.38 35 138593 4977 46542457
Laryngitis 9.79 9.38 54 138574 9262 46538172
Toxoplasmosis 9.77 9.38 16 138612 1378 46546056
Femur fracture 9.73 9.38 67 138561 36930 46510504
Natural killer-cell leukaemia 9.73 9.38 4 138624 41 46547393
Inflammation 9.71 9.38 201 138427 48580 46498854
Pyuria 9.69 9.38 18 138610 1715 46545719
Injection site induration 9.68 9.38 6 138622 8073 46539361
Parvimonas micra infection 9.67 9.38 3 138625 12 46547422
Cells in urine 9.66 9.38 6 138622 155 46547279
Haemodynamic instability 9.66 9.38 47 138581 7678 46539756
Bacillus infection 9.63 9.38 8 138620 329 46547105
Central nervous system lesion 9.61 9.38 55 138573 9560 46537874
Micrococcal sepsis 9.56 9.38 4 138624 43 46547391
Burning sensation 9.55 9.38 85 138543 44326 46503108
Thyroid cyst 9.50 9.38 10 138618 557 46546877
Graft ischaemia 9.48 9.38 4 138624 44 46547390
CSF test abnormal 9.47 9.38 8 138620 337 46547097
Arterial rupture 9.47 9.38 8 138620 337 46547097
Stem cell transplant 9.44 9.38 18 138610 1748 46545686
Glomerulonephritis membranous 9.44 9.38 10 138618 561 46546873
Butterfly rash 9.43 9.38 13 138615 961 46546473
Hypomagnesaemia 9.43 9.38 34 138594 22176 46525258
Microcytosis 9.42 9.38 6 138622 162 46547272
Subcutaneous haematoma 9.42 9.38 17 138611 1584 46545850
CSF oligoclonal band present 9.42 9.38 5 138623 95 46547339
Herpes simplex viraemia 9.39 9.38 6 138622 163 46547271
Parkinsonism 9.39 9.38 6 138622 7942 46539492

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cytomegalovirus infection 762.83 9.94 602 88317 23072 29840487
Product use in unapproved indication 526.02 9.94 851 88068 72842 29790717
Transplant rejection 335.42 9.94 252 88667 8954 29854605
Kidney transplant rejection 320.01 9.94 226 88693 7283 29856276
Off label use 314.61 9.94 1516 87403 247774 29615785
Graft versus host disease 309.37 9.94 250 88669 9900 29853659
Death 293.23 9.94 380 88539 356903 29506656
Mucormycosis 261.00 9.94 174 88745 5094 29858465
Posterior reversible encephalopathy syndrome 255.96 9.94 210 88709 8497 29855062
Pneumocystis jirovecii pneumonia 248.92 9.94 280 88639 16840 29846719
Aspergillus infection 246.51 9.94 220 88699 9994 29853565
Post transplant lymphoproliferative disorder 231.44 9.94 162 88757 5144 29858415
Multiple organ dysfunction syndrome 225.03 9.94 547 88372 62940 29800619
Completed suicide 224.66 9.94 19 88900 99473 29764086
Bronchopulmonary aspergillosis 192.53 9.94 209 88710 12075 29851484
Drug abuse 184.37 9.94 16 88903 82056 29781503
Epstein-Barr virus infection 174.96 9.94 151 88768 6555 29857004
Fatigue 173.88 9.94 440 88479 320233 29543326
Strongyloidiasis 173.45 9.94 100 88819 2246 29861313
Respiratory failure 170.64 9.94 670 88249 99972 29763587
Drug ineffective for unapproved indication 161.65 9.94 180 88739 10700 29852859
Adenovirus infection 155.81 9.94 117 88802 4151 29859408
Complications of transplanted kidney 153.23 9.94 114 88805 3987 29859572
Dizziness 149.54 9.94 217 88702 194692 29668867
Polyomavirus-associated nephropathy 145.36 9.94 100 88819 3085 29860474
Graft versus host disease in gastrointestinal tract 143.95 9.94 98 88821 2971 29860588
Fall 141.95 9.94 200 88719 181672 29681887
Cytomegalovirus infection reactivation 137.27 9.94 77 88842 1638 29861921
Drug ineffective 134.97 9.94 1572 87347 338815 29524744
Infusion related reaction 133.60 9.94 340 88579 40224 29823335
Thrombotic microangiopathy 132.32 9.94 145 88774 8465 29855094
Acute graft versus host disease 129.13 9.94 120 88799 5744 29857815
Cystitis haemorrhagic 121.26 9.94 106 88813 4681 29858878
Cytomegalovirus viraemia 118.05 9.94 113 88806 5616 29857943
Pneumonia cytomegaloviral 114.15 9.94 82 88837 2714 29860845
Toxicity to various agents 105.40 9.94 231 88688 176952 29686607
Myocardial infarction 105.22 9.94 131 88788 125494 29738065
Cardiac failure congestive 103.59 9.94 61 88858 84346 29779213
Haemophagocytic lymphohistiocytosis 102.99 9.94 136 88783 9655 29853904
Nausea 102.90 9.94 493 88426 296464 29567095
Septic shock 101.70 9.94 416 88503 63191 29800368
BK virus infection 101.34 9.94 92 88827 4272 29859287
Product dose omission issue 100.61 9.94 75 88844 91556 29772003
Cytomegalovirus test positive 99.00 9.94 84 88835 3561 29859998
Candida infection 96.75 9.94 168 88751 15194 29848365
Acute graft versus host disease in skin 91.02 9.94 88 88831 4428 29859131
Syncope 90.02 9.94 72 88847 84831 29778728
Asthenia 89.65 9.94 346 88573 220944 29642615
Graft versus host disease in skin 89.38 9.94 76 88843 3231 29860328
Enterococcal infection 86.14 9.94 114 88805 8110 29855449
Nocardiosis 84.50 9.94 75 88844 3380 29860179
Klebsiella infection 82.42 9.94 102 88817 6785 29856774
Cerebrovascular accident 82.15 9.94 76 88843 83401 29780158
Human herpesvirus 6 infection 81.25 9.94 58 88861 1900 29861659
Delayed graft function 80.02 9.94 55 88864 1694 29861865
Pseudomonas infection 79.99 9.94 125 88794 10357 29853202
Acute graft versus host disease in intestine 79.17 9.94 62 88857 2343 29861216
Steroid diabetes 77.52 9.94 48 88871 1233 29862326
Nephropathy toxic 75.86 9.94 123 88796 10516 29853043
Drug resistance 73.93 9.94 176 88743 19957 29843602
Lymphocyte count decreased 73.70 9.94 170 88749 18885 29844674
Cytomegalovirus colitis 73.32 9.94 59 88860 2320 29861239
Chronic graft versus host disease 73.28 9.94 75 88844 4044 29859515
Renal tubular atrophy 72.52 9.94 43 88876 1019 29862540
Constipation 72.30 9.94 141 88778 112765 29750794
Dehydration 71.80 9.94 163 88756 123376 29740183
Chronic allograft nephropathy 71.34 9.94 44 88875 1122 29862437
Liver transplant rejection 70.92 9.94 56 88863 2142 29861417
Progressive multifocal leukoencephalopathy 70.89 9.94 109 88810 8904 29854655
Pulmonary mucormycosis 68.55 9.94 31 88888 408 29863151
Blood pressure fluctuation 67.52 9.94 156 88763 17347 29846212
Pneumomediastinum 67.39 9.94 50 88869 1741 29861818
Hospitalisation 66.80 9.94 24 88895 44295 29819264
Mycobacterium chelonae infection 64.86 9.94 33 88886 572 29862987
Lymphopenia 64.19 9.94 129 88790 13034 29850525
Hypoglycaemia 62.30 9.94 37 88882 50944 29812615
COVID-19 pneumonia 62.14 9.94 72 88847 4468 29859091
Focal segmental glomerulosclerosis 62.09 9.94 48 88871 1779 29861780
Intentional overdose 61.61 9.94 23 88896 41458 29822101
Bacterial sepsis 60.63 9.94 74 88845 4852 29858707
Overdose 60.58 9.94 98 88821 84239 29779320
Depression 60.47 9.94 110 88809 90327 29773232
Disseminated mucormycosis 58.67 9.94 21 88898 142 29863417
Enterobacter infection 56.90 9.94 48 88871 2018 29861541
Vomiting 56.66 9.94 401 88518 219417 29644142
Kidney fibrosis 56.52 9.94 48 88871 2037 29861522
Phaeohyphomycosis 55.54 9.94 33 88886 785 29862774
Aplasia 55.22 9.94 64 88855 3973 29859586
Confusional state 55.02 9.94 210 88709 134624 29728935
Skin necrosis 54.95 9.94 69 88850 4658 29858901
Fungal infection 54.43 9.94 123 88796 13477 29850082
Pneumocystis jirovecii infection 53.88 9.94 39 88880 1306 29862253
Disseminated intravascular coagulation 53.44 9.94 166 88753 22005 29841554
Infection reactivation 53.40 9.94 34 88885 918 29862641
Cytomegalovirus enteritis 52.13 9.94 25 88894 379 29863180
Coronary artery disease 51.61 9.94 43 88876 49669 29813890
Necrotising retinitis 51.20 9.94 30 88889 695 29862864
Herpes simplex 50.05 9.94 64 88855 4400 29859159
Intentional product use issue 49.50 9.94 227 88692 36213 29827346
Pneumonia fungal 49.38 9.94 71 88848 5462 29858097
Oxygen saturation decreased 49.27 9.94 257 88662 43183 29820376
Immunosuppressant drug level increased 48.96 9.94 65 88854 4637 29858922
Acute respiratory distress syndrome 48.70 9.94 167 88752 23305 29840254
Systemic mycosis 48.12 9.94 35 88884 1181 29862378
Sepsis 47.74 9.94 653 88266 145742 29717817
Cushingoid 47.39 9.94 47 88872 2440 29861119
Transplant failure 47.12 9.94 47 88872 2457 29861102
Viraemia 46.81 9.94 34 88885 1145 29862414
Acinetobacter infection 46.77 9.94 32 88887 978 29862581
Cytomegalovirus chorioretinitis 46.71 9.94 53 88866 3215 29860344
Proteinuria 46.69 9.94 129 88790 16016 29847543
Feeling abnormal 46.60 9.94 60 88859 56696 29806863
Renal tubular necrosis 45.24 9.94 123 88796 15128 29848431
Pneumonia pseudomonal 45.18 9.94 54 88865 3464 29860095
Acute graft versus host disease in liver 44.93 9.94 34 88885 1220 29862339
Disease recurrence 44.83 9.94 117 88802 14044 29849515
Cardiac disorder 44.60 9.94 32 88887 39861 29823698
Pneumatosis intestinalis 44.30 9.94 47 88872 2643 29860916
JC virus infection 44.06 9.94 39 88880 1751 29861808
Pyrexia 43.93 9.94 1164 87755 293325 29570234
Fusarium infection 42.96 9.94 31 88888 1033 29862526
Suicide attempt 42.94 9.94 28 88891 36669 29826890
Chorioretinopathy 42.62 9.94 35 88884 1417 29862142
Incision site pain 42.18 9.94 40 88879 1964 29861595
Transplant dysfunction 42.16 9.94 43 88876 2309 29861250
Rhabdomyolysis 41.89 9.94 78 88841 63502 29800057
Staphylococcal sepsis 41.56 9.94 89 88830 9402 29854157
Pneumonia acinetobacter 41.35 9.94 13 88906 55 29863504
Red blood cells urine positive 41.34 9.94 36 88883 1581 29861978
Anxiety 41.31 9.94 133 88786 89738 29773821
Large intestine perforation 40.96 9.94 78 88841 7573 29855986
Somnolence 40.56 9.94 149 88770 96614 29766945
Myopathy 40.44 9.94 94 88825 10492 29853067
Escherichia infection 40.26 9.94 70 88849 6335 29857224
Injection site pain 39.93 9.94 20 88899 30290 29833269
Hyperglycaemia 39.05 9.94 207 88712 34993 29828566
Serotonin syndrome 38.78 9.94 4 88915 17887 29845672
Renal transplant failure 38.78 9.94 29 88890 1022 29862537
Parvovirus B19 infection 38.71 9.94 23 88896 547 29863012
Product quality issue 38.69 9.94 5 88914 18769 29844790
Varicella zoster virus infection 38.13 9.94 31 88888 1237 29862322
Epstein-Barr virus associated lymphoproliferative disorder 37.34 9.94 35 88884 1693 29861866
Decreased appetite 37.34 9.94 276 88643 149634 29713925
Human herpesvirus 8 infection 37.15 9.94 24 88895 665 29862894
Leukopenia 36.79 9.94 289 88630 55870 29807689
Plasma cell myeloma 36.64 9.94 64 88855 53398 29810161
Wrong technique in product usage process 36.14 9.94 24 88895 31131 29832428
Aggression 35.81 9.94 34 88885 36873 29826686
Malaise 35.81 9.94 320 88599 166642 29696917
Granulomatosis with polyangiitis 35.81 9.94 26 88893 875 29862684
Central nervous system fungal infection 35.79 9.94 17 88902 252 29863307
Pain 35.68 9.94 334 88585 172307 29691252
Blood pressure increased 35.60 9.94 348 88571 71580 29791979
Mycobacterium abscessus infection 35.50 9.94 22 88897 566 29862993
Hypoalbuminaemia 34.45 9.94 91 88828 11001 29852558
Fungal skin infection 34.01 9.94 39 88880 2393 29861166
Diffuse alveolar damage 33.68 9.94 35 88884 1921 29861638
Cytomegalovirus hepatitis 33.45 9.94 17 88902 294 29863265
Dyspnoea 33.38 9.94 745 88174 332550 29531009
Muscle spasms 33.37 9.94 91 88828 64747 29798812
Epstein-Barr viraemia 33.19 9.94 25 88894 891 29862668
Atrial fibrillation 33.05 9.94 187 88732 107937 29755622
Intestinal ischaemia 32.92 9.94 67 88852 6830 29856729
Gastroenteritis norovirus 32.88 9.94 30 88889 1402 29862157
Oliguria 32.85 9.94 70 88849 7369 29856190
Penicillium infection 32.81 9.94 12 88907 87 29863472
Pemphigus 32.09 9.94 28 88891 1233 29862326
Therapy non-responder 31.85 9.94 172 88747 29281 29834278
Blood pressure diastolic abnormal 31.59 9.94 28 88891 1259 29862300
Inappropriate schedule of product administration 31.59 9.94 43 88876 39685 29823874
Diffuse large B-cell lymphoma 31.47 9.94 71 88848 7770 29855789
Graft versus host disease in liver 31.20 9.94 25 88894 977 29862582
Bradycardia 30.78 9.94 96 88823 65430 29798129
Rebound effect 30.67 9.94 30 88889 1531 29862028
Cytomegalovirus enterocolitis 30.60 9.94 23 88896 817 29862742
Glomerulonephritis 30.43 9.94 32 88887 1781 29861778
Immunosuppressant drug level decreased 30.13 9.94 27 88892 1232 29862327
Condition aggravated 29.92 9.94 575 88344 137291 29726268
Fungaemia 29.90 9.94 35 88884 2196 29861363
Dysphagia 29.61 9.94 79 88840 56619 29806940
Vasculitis 29.49 9.94 70 88849 7920 29855639
Parvovirus infection 29.36 9.94 18 88901 454 29863105
Enterococcal bacteraemia 29.30 9.94 28 88891 1388 29862171
Epstein-Barr virus associated lymphoma 29.26 9.94 19 88900 531 29863028
Dural arteriovenous fistula 29.23 9.94 9 88910 35 29863524
Oedema peripheral 29.22 9.94 189 88730 105643 29757916
Drug interaction 29.18 9.94 417 88502 199151 29664408
Cryptococcosis 28.82 9.94 31 88888 1771 29861788
Human polyomavirus infection 28.70 9.94 20 88899 630 29862929
Tremor 28.42 9.94 121 88798 75242 29788317
Pneumothorax 28.33 9.94 109 88810 16084 29847475
Klebsiella sepsis 28.28 9.94 30 88889 1687 29861872
Pulmonary alveolar haemorrhage 28.00 9.94 61 88858 6520 29857039
Dry skin 27.84 9.94 16 88903 22438 29841121
Low birth weight baby 27.79 9.94 58 88861 6018 29857541
Gastrointestinal candidiasis 27.67 9.94 12 88907 142 29863417
Balance disorder 27.52 9.94 41 88878 36452 29827107
Disseminated strongyloidiasis 27.41 9.94 9 88910 45 29863514
Renal graft infection 27.29 9.94 14 88905 247 29863312
Chest pain 27.19 9.94 221 88698 117406 29746153
Respiratory arrest 27.18 9.94 28 88891 29230 29834329
Symptom masked 27.13 9.94 17 88902 446 29863113
American trypanosomiasis 27.05 9.94 13 88906 198 29863361
Antineutrophil cytoplasmic antibody positive 26.93 9.94 17 88902 452 29863107
Ureteric stenosis 26.73 9.94 25 88894 1206 29862353
Lung abscess 26.59 9.94 35 88884 2476 29861083
Contraindicated product administered 26.53 9.94 9 88910 17222 29846337
Lethargy 26.45 9.94 48 88871 39471 29824088
Leukocytosis 26.32 9.94 130 88789 21372 29842187
Blood pressure systolic abnormal 26.01 9.94 27 88892 1480 29862079
Treatment noncompliance 26.01 9.94 22 88897 25231 29838328
Protein urine present 25.96 9.94 49 88870 4726 29858833
Headache 25.92 9.94 383 88536 181923 29681636
Cholelithiasis 25.67 9.94 14 88905 20211 29843348
Pneumoretroperitoneum 25.64 9.94 9 88910 57 29863502
Insomnia 25.60 9.94 167 88752 93169 29770390
Diabetes mellitus 25.54 9.94 212 88707 41653 29821906
Lymphoproliferative disorder 25.48 9.94 33 88886 2297 29861262
Osmotic demyelination syndrome 25.47 9.94 19 88900 667 29862892
International normalised ratio increased 25.32 9.94 66 88853 47673 29815886
Toxic epidermal necrolysis 25.28 9.94 113 88806 17827 29845732
Intentional product misuse 25.14 9.94 40 88879 34627 29828932
Pathogen resistance 25.11 9.94 68 88851 8342 29855217
Cytomegalovirus oesophagitis 25.01 9.94 13 88906 236 29863323
Reticulocytosis 24.91 9.94 14 88905 299 29863260
Autoimmune colitis 24.75 9.94 20 88899 791 29862768
Haemolytic uraemic syndrome 24.52 9.94 30 88889 1972 29861587
Hepatic artery thrombosis 24.39 9.94 13 88906 249 29863310
Hallucination 24.39 9.94 70 88849 48989 29814570
Myalgia 24.29 9.94 131 88788 76536 29787023
Herpes zoster meningoencephalitis 24.21 9.94 13 88906 253 29863306
Pneumoperitoneum 24.12 9.94 27 88892 1613 29861946
Angiosarcoma 24.07 9.94 13 88906 256 29863303
Suicidal ideation 24.05 9.94 44 88875 36070 29827489
COVID-19 23.99 9.94 111 88808 17767 29845792
Lupus nephritis 23.80 9.94 13 88906 262 29863297
Apoptosis 23.79 9.94 12 88907 204 29863355
Erectile dysfunction 23.76 9.94 12 88907 18090 29845469
Contusion 23.73 9.94 35 88884 31245 29832314
Immune reconstitution inflammatory syndrome 23.67 9.94 70 88849 9031 29854528
Bronchopneumopathy 23.59 9.94 15 88904 404 29863155
Graft loss 23.52 9.94 20 88899 850 29862709
Intensive care unit acquired weakness 23.48 9.94 20 88899 852 29862707
Agitation 23.48 9.94 82 88837 53991 29809568
Glomerulosclerosis 23.36 9.94 18 88901 664 29862895
Intra-abdominal haemorrhage 23.35 9.94 30 88889 2072 29861487
Atypical mycobacterial pneumonia 23.31 9.94 10 88909 115 29863444
Cavernous sinus thrombosis 23.16 9.94 10 88909 117 29863442
Loss of personal independence in daily activities 23.13 9.94 18 88901 21517 29842042
Scopulariopsis infection 23.08 9.94 10 88909 118 29863441
Pyelonephritis acute 23.05 9.94 26 88893 1567 29861992
Listeriosis 23.01 9.94 20 88899 876 29862683
Nephrotic syndrome 22.94 9.94 58 88861 6827 29856732
Dermatophytosis 22.84 9.94 12 88907 223 29863336
Unevaluable event 22.74 9.94 37 88882 31748 29831811
Hypogammaglobulinaemia 22.71 9.94 49 88870 5203 29858356
Systemic candida 22.54 9.94 34 88885 2730 29860829
Transient ischaemic attack 22.42 9.94 25 88894 25175 29838384
Cytomegalovirus gastrointestinal infection 22.36 9.94 10 88909 128 29863431
Psoriasis 22.36 9.94 59 88860 42447 29821112
Loss of consciousness 22.28 9.94 141 88778 79234 29784325
Chimerism 22.27 9.94 9 88910 88 29863471
Hyperhidrosis 22.17 9.94 113 88806 66977 29796582
Blood pressure systolic increased 21.92 9.94 96 88823 15014 29848545
Opportunistic infection 21.86 9.94 23 88896 1281 29862278
Blood beta-D-glucan increased 21.82 9.94 15 88904 462 29863097
Monocytopenia 21.66 9.94 9 88910 95 29863464
Cystitis escherichia 21.65 9.94 11 88908 190 29863369
Neuromyelitis optica spectrum disorder 21.63 9.94 10 88909 139 29863420
Stress 21.62 9.94 17 88902 20218 29843341
Arrhythmia 21.56 9.94 41 88878 33128 29830431
Device related sepsis 21.52 9.94 30 88889 2242 29861317
Back pain 21.37 9.94 198 88721 102398 29761161
Neutrophil percentage increased 21.33 9.94 27 88892 1837 29861722
Dyskinesia 21.31 9.94 20 88899 21814 29841745
Accidental overdose 21.30 9.94 14 88905 18261 29845298
Urine analysis abnormal 21.29 9.94 27 88892 1841 29861718
Rheumatoid arthritis 21.20 9.94 201 88718 40996 29822563
Amoebic colitis 21.16 9.94 7 88912 36 29863523
Limbic encephalitis 21.11 9.94 12 88907 262 29863297
Aplastic anaemia 20.85 9.94 49 88870 5507 29858052
Pneumonia adenoviral 20.77 9.94 10 88909 153 29863406
Complications of transplant surgery 20.71 9.94 15 88904 503 29863056
Torulopsis infection 20.67 9.94 6 88913 18 29863541
Polychondritis 20.65 9.94 10 88909 155 29863404
Skin striae 20.63 9.94 14 88905 422 29863137
Osteoporosis 20.50 9.94 74 88845 10589 29852970
Graft complication 20.48 9.94 13 88906 349 29863210
Treatment failure 20.30 9.94 174 88745 34505 29829054
Cardiac arrest 20.29 9.94 177 88742 92673 29770886
Pancytopenia 20.26 9.94 360 88559 84692 29778867
Listeria sepsis 20.26 9.94 10 88909 162 29863397
Cutaneous malacoplakia 20.12 9.94 7 88912 43 29863516
Accidental exposure to product 20.12 9.94 3 88916 10112 29853447
Fungal endocarditis 20.09 9.94 10 88909 165 29863394
Depressed mood 19.91 9.94 13 88906 17016 29846543
Necrosis ischaemic 19.91 9.94 11 88908 227 29863332
Trichophytosis 19.88 9.94 12 88907 294 29863265
IgA nephropathy 19.86 9.94 19 88900 943 29862616
Hypophagia 19.85 9.94 22 88897 22214 29841345
Obliterative bronchiolitis 19.85 9.94 21 88898 1177 29862382
Thrombocytopenia 19.84 9.94 540 88379 136504 29727055
Immunosuppression 19.82 9.94 46 88873 5129 29858430
Lymphocele 19.72 9.94 23 88896 1437 29862122
Unresponsive to stimuli 19.61 9.94 30 88889 26389 29837170
Hepatitis A 19.55 9.94 14 88905 461 29863098
Restlessness 19.48 9.94 23 88896 22576 29840983
Extrapyramidal disorder 19.46 9.94 4 88915 10689 29852870
Autoimmune hepatitis 19.44 9.94 37 88882 3590 29859969
Red blood cell schistocytes present 19.39 9.94 12 88907 308 29863251
Blood creatine phosphokinase increased 19.37 9.94 66 88853 43782 29819777
Cerebral aspergillosis 19.37 9.94 22 88897 1336 29862223
Acute myocardial infarction 19.34 9.94 86 88833 52853 29810706
Haemodynamic instability 19.30 9.94 60 88859 7955 29855604
Irritability 19.29 9.94 24 88895 23026 29840533
Hepatitis E 19.25 9.94 24 88895 1608 29861951
Poisoning 19.24 9.94 5 88914 11377 29852182
Bacteraemia 18.99 9.94 94 88825 15466 29848093
Eschar 18.90 9.94 15 88904 578 29862981
Corynebacterium infection 18.89 9.94 13 88906 401 29863158
Herpes simplex hepatitis 18.88 9.94 8 88911 89 29863470
Urine abnormality 18.74 9.94 23 88896 1516 29862043
Oral herpes 18.62 9.94 41 88878 4414 29859145
Seronegative arthritis 18.60 9.94 17 88902 796 29862763
Cerebral venous thrombosis 18.59 9.94 15 88904 592 29862967
Disseminated trichosporonosis 18.54 9.94 7 88912 56 29863503
Blood pressure diastolic increased 18.46 9.94 31 88888 2727 29860832
Pneumonia escherichia 18.24 9.94 12 88907 343 29863216
Pneumonia influenzal 18.24 9.94 21 88898 1294 29862265
Lymphangitis 18.22 9.94 14 88905 514 29863045
Uraemic encephalopathy 18.21 9.94 11 88908 270 29863289
Adenoviral haemorrhagic cystitis 18.18 9.94 13 88906 427 29863132
Blood count abnormal 18.09 9.94 6 88913 11646 29851913
Gastritis fungal 18.06 9.94 8 88911 100 29863459
Abdominal abscess 18.05 9.94 38 88881 3966 29859593
Herpes zoster 17.92 9.94 151 88768 29792 29833767
Enterococcus test positive 17.92 9.94 17 88902 835 29862724
Exposure during pregnancy 17.85 9.94 3 88916 9258 29854301
Steroid withdrawal syndrome 17.81 9.94 10 88909 213 29863346
Product substitution issue 17.76 9.94 4 88915 10031 29853528
Herpes simplex colitis 17.75 9.94 5 88914 13 29863546
Pleural mass 17.73 9.94 7 88912 64 29863495
Necrosis 17.64 9.94 44 88875 5135 29858424
Lymphocyte percentage decreased 17.50 9.94 26 88893 2060 29861499
Acute endocarditis 17.48 9.94 5 88914 14 29863545
Nightmare 17.42 9.94 7 88912 12069 29851490
Diarrhoea haemorrhagic 17.39 9.94 47 88872 5758 29857801
Diarrhoea 17.37 9.94 813 88106 333290 29530269
Viral cardiomyopathy 17.37 9.94 6 88913 36 29863523
Encephalitis brain stem 17.36 9.94 7 88912 68 29863491
Subcapsular renal haematoma 17.36 9.94 12 88907 373 29863186
Acne fulminans 17.24 9.94 9 88910 165 29863394
Encephalitis 17.21 9.94 50 88869 6386 29857173
Quadriplegia 17.20 9.94 22 88897 1513 29862046
Endocarditis 17.19 9.94 48 88871 5995 29857564
Therapy cessation 17.10 9.94 12 88907 15125 29848434
Gait disturbance 17.03 9.94 141 88778 74636 29788923
Haematopoietic stem cell mobilisation 17.00 9.94 9 88910 170 29863389
Pupils unequal 16.99 9.94 20 88899 1262 29862297
Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids 16.99 9.94 5 88914 16 29863543
Central nervous system vasculitis 16.97 9.94 12 88907 387 29863172
Pulmonary nocardiosis 16.97 9.94 12 88907 387 29863172
Cutaneous mucormycosis 16.96 9.94 6 88913 39 29863520
Intestine transplant rejection 16.96 9.94 6 88913 39 29863520
Small intestinal perforation 16.94 9.94 23 88896 1676 29861883
Cytomegalovirus nephritis 16.94 9.94 8 88911 117 29863442
Swollen tongue 16.93 9.94 9 88910 13183 29850376
B-lymphocyte count decreased 16.93 9.94 13 88906 477 29863082
Arteriosclerosis coronary artery 16.92 9.94 6 88913 11170 29852389
Abdominal discomfort 16.79 9.94 81 88838 48710 29814849
Visceral leishmaniasis 16.79 9.94 13 88906 483 29863076
Arterial spasm 16.76 9.94 8 88911 120 29863439
Bifidobacterium infection 16.76 9.94 5 88914 17 29863542
Activated partial thromboplastin time shortened 16.68 9.94 12 88907 398 29863161
Bursitis infective 16.65 9.94 13 88906 489 29863070
Transaminases increased 16.63 9.94 123 88796 23334 29840225
Osteonecrosis 16.62 9.94 93 88826 16042 29847517
Bordetella infection 16.58 9.94 6 88913 42 29863517
Heart rate decreased 16.58 9.94 113 88806 20881 29842678
Glomerulonephritis minimal lesion 16.57 9.94 12 88907 402 29863157
Pruritus 16.54 9.94 249 88670 117955 29745604
Chemotherapeutic drug level above therapeutic 16.54 9.94 5 88914 18 29863541
Subperiosteal abscess 16.53 9.94 4 88915 4 29863555
Arthritis fungal 16.51 9.94 7 88912 78 29863481
Meningitis fungal 16.47 9.94 8 88911 125 29863434
Encephalitis fungal 16.41 9.94 9 88910 183 29863376
Peritoneal candidiasis 16.33 9.94 5 88914 19 29863540
Pneumonia cryptococcal 16.26 9.94 15 88904 711 29862848
Ureteric anastomosis complication 16.23 9.94 6 88913 45 29863514
Granuloma 16.16 9.94 27 88892 2365 29861194
Spermatozoa progressive motility decreased 16.13 9.94 8 88911 131 29863428
Disseminated varicella zoster vaccine virus infection 16.00 9.94 6 88913 47 29863512
Splenic necrosis 16.00 9.94 6 88913 47 29863512
Central nervous system lesion 16.00 9.94 41 88878 4865 29858694
Cardio-respiratory arrest 15.97 9.94 102 88817 57204 29806355
Injection site reaction 15.91 9.94 6 88913 10754 29852805
Psoriatic arthropathy 15.90 9.94 14 88905 15747 29847812
Laboratory test abnormal 15.85 9.94 17 88902 17425 29846134
Escherichia sepsis 15.84 9.94 36 88883 3958 29859601
Neuroleptic malignant syndrome 15.82 9.94 15 88904 16280 29847279
Encephalitis autoimmune 15.78 9.94 12 88907 434 29863125
Thyroiditis subacute 15.75 9.94 5 88914 22 29863537
Lymphocytosis 15.74 9.94 24 88895 1946 29861613
Heart transplant rejection 15.71 9.94 19 88900 1234 29862325
Respiratory distress 15.56 9.94 158 88761 32814 29830745
Respiratory disorder 15.55 9.94 97 88822 17397 29846162
Crystal urine present 15.54 9.94 10 88909 275 29863284
Tularaemia 15.49 9.94 7 88912 92 29863467
Respiratory tract infection fungal 15.44 9.94 14 88905 649 29862910
Mobility decreased 15.32 9.94 34 88885 25965 29837594
Dyspepsia 15.27 9.94 43 88876 30286 29833273
Inflammatory marker increased 15.25 9.94 31 88888 3157 29860402
Peliosis hepatis 15.18 9.94 6 88913 55 29863504
Colitis 15.18 9.94 149 88770 30671 29832888
Incorrect dose administered 15.17 9.94 46 88873 31640 29831919
Pain in extremity 15.14 9.94 233 88686 109988 29753571
Neuropathy peripheral 15.11 9.94 135 88784 70340 29793219
Ophthalmoplegia 15.10 9.94 19 88900 1285 29862274
Hypertension 15.04 9.94 469 88450 120885 29742674
Accelerated idioventricular rhythm 15.00 9.94 6 88913 57 29863502
Multiple sclerosis relapse 14.99 9.94 68 88851 10794 29852765
Acanthamoeba keratitis 14.91 9.94 7 88912 101 29863458
Systemic inflammatory response syndrome 14.84 9.94 48 88871 6498 29857061
Henoch-Schonlein purpura 14.74 9.94 20 88899 1457 29862102
Blood immunoglobulin G decreased 14.73 9.94 16 88903 924 29862635
Biopsy lymph gland 14.73 9.94 6 88913 60 29863499
Stenotrophomonas infection 14.72 9.94 21 88898 1603 29861956
Acute kidney injury 14.69 9.94 664 88255 273178 29590381
Pulmonary haemorrhage 14.65 9.94 61 88858 9331 29854228
Hepatic failure 14.59 9.94 160 88759 33883 29829676
Injection site swelling 14.57 9.94 4 88915 8776 29854783
Dehiscence 14.55 9.94 6 88913 62 29863497
Faeces discoloured 14.55 9.94 12 88907 13934 29849625
Acinetobacter bacteraemia 14.54 9.94 7 88912 107 29863452
Paranoia 14.54 9.94 6 88913 10182 29853377
Scedosporium infection 14.53 9.94 14 88905 701 29862858
Engraftment syndrome 14.51 9.94 15 88904 818 29862741
Graft infection 14.48 9.94 11 88908 397 29863162
Peripheral swelling 14.44 9.94 114 88805 60960 29802599
Post procedural urine leak 14.44 9.94 8 88911 166 29863393
Orthostatic hypotension 14.42 9.94 31 88888 23948 29839611
Kidney rupture 14.40 9.94 9 88910 235 29863324
Splenic embolism 14.37 9.94 7 88912 110 29863449
Phaeohyphomycotic brain abscess 14.34 9.94 5 88914 31 29863528
Semen volume decreased 14.32 9.94 10 88909 316 29863243
Asthma 14.30 9.94 57 88862 36117 29827442
Leishmaniasis 14.29 9.94 10 88909 317 29863242
Neutrophil count increased 14.27 9.94 86 88833 15237 29848322
Peritonitis bacterial 14.26 9.94 8 88911 11370 29852189
Palatal ulcer 14.20 9.94 5 88914 32 29863527
Herpes zoster cutaneous disseminated 14.18 9.94 8 88911 172 29863387
Gastroenteritis rotavirus 14.18 9.94 8 88911 172 29863387
Epstein Barr virus positive mucocutaneous ulcer 14.17 9.94 9 88910 242 29863317
Chronic papillomatous dermatitis 14.14 9.94 6 88913 67 29863492
Hypersomnia 14.12 9.94 8 88911 11308 29852251
Hypotension 14.10 9.94 471 88448 200094 29663465
Pericarditis fungal 14.02 9.94 8 88911 176 29863383
Coma 14.00 9.94 67 88852 40382 29823177
Pelvic venous thrombosis 13.95 9.94 12 88907 518 29863041
Foetal growth restriction 13.87 9.94 32 88887 3553 29860006
Colorectal adenocarcinoma 13.86 9.94 8 88911 180 29863379
Mucosal ulceration 13.86 9.94 15 88904 863 29862696
Papilloedema 13.84 9.94 25 88894 2331 29861228
Blood sodium decreased 13.81 9.94 16 88903 15840 29847719
Secondary immunodeficiency 13.79 9.94 10 88909 336 29863223
Epstein-Barr virus test positive 13.78 9.94 12 88907 527 29863032
Herpes virus infection 13.70 9.94 26 88893 2518 29861041
Trichosporon infection 13.68 9.94 13 88906 640 29862919
Autoimmune thyroiditis 13.66 9.94 16 88903 1004 29862555
Lung transplant rejection 13.63 9.94 14 88905 758 29862801
Congenital cardiovascular anomaly 13.59 9.94 8 88911 187 29863372
Viral sepsis 13.58 9.94 5 88914 37 29863522
Prostate cancer 13.57 9.94 32 88887 23925 29839634
Medication error 13.56 9.94 26 88893 20946 29842613
Kaposi's sarcoma 13.56 9.94 16 88903 1012 29862547
Paraneoplastic neurological syndrome 13.54 9.94 4 88915 13 29863546
Full blood count decreased 13.54 9.94 16 88903 15701 29847858
Sideroblastic anaemia 13.52 9.94 7 88912 126 29863433
Hyperkalaemia 13.47 9.94 128 88791 65882 29797677
Pulmonary fibrosis 13.43 9.94 87 88832 15803 29847756
Executive dysfunction 13.42 9.94 7 88912 128 29863431
Urinary fistula 13.37 9.94 7 88912 129 29863430
Venoocclusive disease 13.37 9.94 26 88893 2564 29860995
Pneumonia klebsiella 13.37 9.94 26 88893 2564 29860995
Dysgeusia 13.37 9.94 34 88885 24767 29838792
Urobilinogen urine increased 13.36 9.94 10 88909 353 29863206
Diaphragmatic injury 13.36 9.94 5 88914 39 29863520
Drug withdrawal syndrome 13.30 9.94 24 88895 19785 29843774
Radiotherapy to brain 13.25 9.94 5 88914 40 29863519
Myoclonus 13.22 9.94 12 88907 13300 29850259
Cerebral fungal infection 13.22 9.94 8 88911 197 29863362
Splenic infection fungal 13.20 9.94 6 88913 80 29863479
Serum sickness 13.17 9.94 21 88898 1769 29861790
Hypertensive encephalopathy 13.16 9.94 10 88909 361 29863198
Pleuropericarditis 13.15 9.94 8 88911 199 29863360
Amoebiasis 13.14 9.94 5 88914 41 29863518
Immune-mediated enterocolitis 13.13 9.94 16 88903 1047 29862512
Brain oedema 13.13 9.94 72 88847 12326 29851233
Injection site erythema 13.12 9.94 13 88906 13821 29849738
Meconium peritonitis 13.10 9.94 4 88915 15 29863544
Intestinal ulcer 13.08 9.94 14 88905 795 29862764
Hilar lymphadenopathy 13.00 9.94 14 88905 801 29862758
Megacolon 12.97 9.94 20 88899 1637 29861922
Abnormal dreams 12.91 9.94 4 88915 8111 29855448
New onset diabetes after transplantation 12.90 9.94 4 88915 16 29863543
Carotid artery insufficiency 12.90 9.94 4 88915 16 29863543
Glycosylated haemoglobin increased 12.90 9.94 6 88913 9485 29854074
Epididymitis 12.86 9.94 24 88895 2295 29861264
Lymphocytic infiltration 12.81 9.94 12 88907 580 29862979
Mixed liver injury 12.81 9.94 22 88897 1971 29861588
Coombs direct test positive 12.79 9.94 9 88910 288 29863271
Central nervous system infection 12.75 9.94 11 88908 477 29863082
Alveolar proteinosis 12.74 9.94 9 88910 290 29863269
Sedation 12.73 9.94 18 88901 16355 29847204
Marrow hyperplasia 12.70 9.94 15 88904 950 29862609
Microsporidia infection 12.61 9.94 12 88907 592 29862967
Bacillus infection 12.60 9.94 8 88911 215 29863344
Meningitis cryptococcal 12.56 9.94 22 88897 2002 29861557
Passenger lymphocyte syndrome 12.53 9.94 4 88915 18 29863541
Intentional self-injury 12.51 9.94 13 88906 13519 29850040
Neurological symptom 12.50 9.94 30 88889 3417 29860142
Blindness cortical 12.42 9.94 9 88910 302 29863257
Pasteurella infection 12.40 9.94 3 88916 3 29863556
Neonatal multi-organ failure 12.40 9.94 3 88916 3 29863556
Inhibin B 12.35 9.94 4 88915 19 29863540
Subcutaneous emphysema 12.31 9.94 15 88904 982 29862577
Mycobacterium kansasii infection 12.25 9.94 8 88911 226 29863333
Tuberculosis 12.24 9.94 52 88867 8025 29855534
Myocarditis infectious 12.18 9.94 4 88915 20 29863539
ADAMTS13 activity decreased 12.17 9.94 6 88913 97 29863462
Disseminated cryptococcosis 12.16 9.94 15 88904 994 29862565
Gastric perforation 12.12 9.94 22 88897 2059 29861500
Idiopathic pneumonia syndrome 12.12 9.94 8 88911 230 29863329
Donor specific antibody present 12.11 9.94 6 88913 98 29863461
Bronchitis bacterial 12.11 9.94 13 88906 741 29862818
Miosis 12.08 9.94 4 88915 7772 29855787
Memory impairment 12.05 9.94 63 88856 37111 29826448
Pneumonia necrotising 12.02 9.94 11 88908 516 29863043
Necrotising soft tissue infection 12.02 9.94 5 88914 53 29863506
Angina pectoris 11.99 9.94 46 88873 29472 29834087
Post procedural bile leak 11.94 9.94 9 88910 321 29863238
Rash papulosquamous 11.93 9.94 5 88914 54 29863505
Hypothalamo-pituitary disorder 11.92 9.94 12 88907 634 29862925
Abdominal infection 11.90 9.94 18 88901 1449 29862110
Multi-organ disorder 11.87 9.94 16 88903 1158 29862401
Abscess sterile 11.87 9.94 4 88915 22 29863537
Ventricular extrasystoles 11.81 9.94 10 88909 11464 29852095
C-reactive protein increased 11.80 9.94 188 88731 43285 29820274
Dry mouth 11.80 9.94 32 88887 22818 29840741
Adverse event 11.80 9.94 17 88902 15324 29848235
Glucose tolerance impaired 11.78 9.94 26 88893 2804 29860755
Pneumonitis 11.75 9.94 129 88790 27325 29836234
Eosinophil percentage decreased 11.69 9.94 6 88913 106 29863453
Nephrogenic diabetes insipidus 11.67 9.94 16 88903 1177 29862382
Adenomatous polyposis coli 11.65 9.94 7 88912 170 29863389
Hemianopia 11.62 9.94 12 88907 654 29862905
Pneumonia bacterial 11.61 9.94 57 88862 9346 29854213
Immune thrombocytopenia 11.60 9.94 49 88870 7542 29856017
Gastrointestinal wall thickening 11.60 9.94 14 88905 907 29862652
Urinary tract infection bacterial 11.60 9.94 18 88901 1482 29862077
Gastrointestinal haemorrhage 11.59 9.94 176 88743 83270 29780289
Periventricular haemorrhage neonatal 11.58 9.94 4 88915 24 29863535
Salivary hypersecretion 11.56 9.94 4 88915 7562 29855997
Body height below normal 11.54 9.94 8 88911 250 29863309
Erythema infectiosum 11.47 9.94 7 88912 175 29863384
Perinephric collection 11.47 9.94 7 88912 175 29863384
Fluid retention 11.47 9.94 37 88882 24961 29838598
Thyrotoxic periodic paralysis 11.47 9.94 5 88914 60 29863499
Blindness 11.41 9.94 69 88850 12240 29851319
Febrile bone marrow aplasia 11.41 9.94 51 88868 8046 29855513
Hepatitis cholestatic 11.40 9.94 50 88869 7822 29855737
Pancreas transplant rejection 11.40 9.94 7 88912 177 29863382
Poikiloderma 11.37 9.94 7 88912 178 29863381
Vision blurred 11.36 9.94 75 88844 41741 29821818
Nervous system disorder 11.32 9.94 72 88847 12997 29850562
Haptoglobin decreased 11.22 9.94 11 88908 563 29862996
Diffuse mesangial sclerosis 11.19 9.94 3 88916 6 29863553
Haemolytic anaemia 11.19 9.94 59 88860 9951 29853608
Candida sepsis 11.15 9.94 15 88904 1084 29862475
Bacterial pyelonephritis 11.13 9.94 8 88911 265 29863294
Sarcopenia 11.10 9.94 8 88911 266 29863293
Drug eruption 11.10 9.94 22 88897 17504 29846055
Hepatic cirrhosis 11.09 9.94 19 88900 15980 29847579
Blood pressure decreased 11.06 9.94 88 88831 46987 29816572
Venous haemorrhage 11.06 9.94 4 88915 28 29863531
Enterobacter bacteraemia 11.05 9.94 8 88911 268 29863291
Thyroid gland abscess 11.04 9.94 5 88914 66 29863493
Panic attack 11.03 9.94 6 88913 8675 29854884
Enterococcal sepsis 11 9.94 18 88901 1550 29862009
Neuromyopathy 11.00 9.94 14 88905 958 29862601
Gastrointestinal ulcer 10.98 9.94 19 88900 1713 29861846
Malocclusion 10.98 9.94 5 88914 67 29863492
Ureaplasma infection 10.96 9.94 7 88912 190 29863369
Lung consolidation 10.95 9.94 36 88883 4916 29858643
Gonococcal infection 10.94 9.94 4 88915 29 29863530
Haemorrhagic cholecystitis 10.94 9.94 4 88915 29 29863530
Cerebellar ataxia 10.86 9.94 14 88905 970 29862589
Disseminated varicella zoster virus infection 10.86 9.94 14 88905 970 29862589
Right ventricular diastolic collapse 10.85 9.94 5 88914 69 29863490
Unmasking of previously unidentified disease 10.84 9.94 11 88908 587 29862972
Gait inability 10.81 9.94 25 88894 18816 29844743
Acanthamoeba infection 10.79 9.94 10 88909 477 29863082
Pulmonary vasculitis 10.78 9.94 5 88914 70 29863489
Poor quality sleep 10.77 9.94 4 88915 7237 29856322
Microscopic polyangiitis 10.76 9.94 6 88913 126 29863433
Wolff-Parkinson-White syndrome 10.74 9.94 7 88912 197 29863362
Embolia cutis medicamentosa 10.74 9.94 7 88912 197 29863362
Lower gastrointestinal haemorrhage 10.74 9.94 5 88914 7899 29855660
Skin discolouration 10.73 9.94 19 88900 15775 29847784
Disseminated tuberculosis 10.73 9.94 21 88898 2081 29861478
Refractory cancer 10.72 9.94 6 88913 127 29863432
Swelling face 10.72 9.94 30 88889 21174 29842385
Hypoaesthesia 10.71 9.94 106 88813 54124 29809435
Drug level below therapeutic 10.71 9.94 28 88891 3364 29860195
Viral haemorrhagic cystitis 10.70 9.94 13 88906 848 29862711
Polychromasia 10.68 9.94 6 88913 128 29863431
Jejunal perforation 10.68 9.94 7 88912 199 29863360
Blastomycosis 10.60 9.94 8 88911 286 29863273
Eye luxation 10.59 9.94 3 88916 8 29863551
Oesophageal candidiasis 10.59 9.94 32 88887 4178 29859381
Hypoacusis 10.55 9.94 16 88903 14123 29849436
Dental caries 10.51 9.94 33 88886 4398 29859161
Mitral valve prolapse 10.49 9.94 11 88908 610 29862949
Muscle rigidity 10.49 9.94 9 88910 10252 29853307
Hypocomplementaemia 10.49 9.94 4 88915 33 29863526
Neuromyotonia 10.49 9.94 4 88915 33 29863526
Bone marrow disorder 10.48 9.94 17 88902 1453 29862106
Fear 10.47 9.94 10 88909 10815 29852744
Neutrophilic dermatosis 10.46 9.94 7 88912 206 29863353
Viral myocarditis 10.40 9.94 6 88913 135 29863424
White blood cell count decreased 10.35 9.94 181 88738 83766 29779793
Autoimmune haemolytic anaemia 10.35 9.94 31 88888 4028 29859531
Blood 1,25-dihydroxycholecalciferol increased 10.34 9.94 3 88916 9 29863550
Large granular lymphocytosis 10.32 9.94 6 88913 137 29863422
Rhinovirus infection 10.29 9.94 25 88894 2870 29860689
Biliary cyst 10.29 9.94 4 88915 35 29863524
Citrobacter infection 10.24 9.94 10 88909 509 29863050
Cardiac failure 10.24 9.94 180 88739 83238 29780321
Enteritis 10.24 9.94 43 88876 6602 29856957
Ischaemic cardiomyopathy 10.21 9.94 3 88916 6294 29857265
Blood urea increased 10.20 9.94 140 88779 31241 29832318
Ocular lymphoma 10.19 9.94 4 88915 36 29863523
Keratosis follicular 10.19 9.94 4 88915 36 29863523
Therapeutic product effect decreased 10.16 9.94 48 88871 29028 29834531
Madarosis 10.14 9.94 7 88912 217 29863342
Optic atrophy 10.11 9.94 12 88907 764 29862795
Eczema 10.10 9.94 15 88904 13354 29850205
Systemic lupus erythematosus 10.10 9.94 23 88896 2533 29861026
Blood loss anaemia 10.09 9.94 5 88914 7622 29855937
Blood immunoglobulin M decreased 10.07 9.94 9 88910 409 29863150
Intestinal anastomosis 10.06 9.94 7 88912 220 29863339
Trichodysplasia spinulosa 10.06 9.94 7 88912 220 29863339
Drug intolerance 10.04 9.94 86 88833 45205 29818354
Tongue fungal infection 10.00 9.94 4 88915 38 29863521
Blood creatinine increased 9.99 9.94 348 88571 91027 29772532
Disturbance in attention 9.98 9.94 33 88886 22096 29841463
Pyuria 9.98 9.94 11 88908 646 29862913
Oligospermia 9.97 9.94 5 88914 84 29863475
Viral load abnormal 9.97 9.94 5 88914 84 29863475
Substance-induced psychotic disorder 9.97 9.94 16 88903 1356 29862203

Pharmacologic Action:

SourceCodeDescription
ATC D07AA01 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, PLAIN
Corticosteroids, weak (group I)
ATC D10AA02 DERMATOLOGICALS
ANTI-ACNE PREPARATIONS
ANTI-ACNE PREPARATIONS FOR TOPICAL USE
Corticosteroids, combinations for treatment of acne
ATC H02AB04 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
CORTICOSTEROIDS FOR SYSTEMIC USE
CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
Glucocorticoids
ATC D07CA02 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, COMBINATIONS WITH ANTIBIOTICS
Corticosteroids, weak, combinations with antibiotics
ATC H02BX01 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
CORTICOSTEROIDS FOR SYSTEMIC USE
CORTICOSTEROIDS FOR SYSTEMIC USE, COMBINATIONS
Corticosteroids for systemic use, combinations
ATC S01CA08 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids and antiinfectives in combination
FDA MoA N0000175450 Corticosteroid Hormone Receptor Agonists
FDA EPC N0000175576 Corticosteroid
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000932 Antiemetics
MeSH PA D002491 Central Nervous System Agents
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D005938 Glucocorticoids
MeSH PA D006728 Hormones
MeSH PA D018696 Neuroprotective Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D020011 Protective Agents
CHEBI has role CHEBI:35472 anti-inflammatory drugs
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:37962 adrenergic neuron agents
CHEBI has role CHEBI:50919 antiemetico
CHEBI has role CHEBI:63726 neuroprotective agents
CHEBI has role CHEBI:78298 environmental contaminants

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Disorder of musculoskeletal system indication 928000 DOID:17
Cerebral edema indication 2032001
Berylliosis indication 8247009 DOID:10322
Psoriasis indication 9014002 DOID:8893
Ankylosing spondylitis indication 9631008 DOID:7147
Rheumatic heart disease indication 23685000
Atopic dermatitis indication 24079001 DOID:3310
Inflammatory bowel disease indication 24526004 DOID:0050589
Multiple sclerosis indication 24700007 DOID:2377
Severe adrenal insufficiency indication 24867002
Sarcoidosis indication 31541009 DOID:11335
Idiopathic thrombocytopenic purpura indication 32273002 DOID:8924
Psoriasis with arthropathy indication 33339001
Crohn's disease indication 34000006
Tendinitis indication 34840004 DOID:971
Erythema multiforme indication 36715001
Contact dermatitis indication 40275004 DOID:2773
Angioedema indication 41291007 DOID:1558
Miliary tuberculosis indication 47604008 DOID:9861
Humoral hypercalcemia of malignancy indication 47709007
Articular gout indication 48440001 DOID:13189
Seborrheic dermatitis indication 50563003 DOID:8741
Edema of larynx indication 51599000
Nephrotic syndrome indication 52254009 DOID:1184
Lichen simplex chronicus indication 53891004
Systemic lupus erythematosus indication 55464009 DOID:9074
Allergic rhinitis indication 61582004
Löffler's syndrome indication 64936001 DOID:9503
Pemphigus indication 65172003 DOID:9182
Granuloma annulare indication 65508009 DOID:3777
Tenosynovitis indication 67801009 DOID:970
Rheumatoid arthritis indication 69896004 DOID:7148
Transfusion reaction due to serum protein reaction indication 72284000
Epicondylitis indication 73583000 DOID:14087
Acquired thrombocytopenia indication 74576004 DOID:11126
Thyroiditis indication 82119001 DOID:7166
Bursitis indication 84017003 DOID:2965
Autoimmune disease indication 85828009
Infection by larvae of Trichinella spiralis indication 88264003
Congenital hypoplastic anemia indication 88854002 DOID:1339
Pruritus ani indication 90446007
Acute lymphoid leukemia indication 91857003 DOID:9952
Disorder of skin indication 95320005 DOID:37
Dermatitis herpetiformis indication 111196000 DOID:8505
Hodgkin's disease indication 118599009
Non-Hodgkin's lymphoma indication 118601006
Mycosis fungoides indication 118618005
Aspiration pneumonitis indication 155597006
Asthma indication 195967001 DOID:2841
Discoid lupus erythematosus indication 200938002
Plaque psoriasis indication 200965009
Transplanted organ rejection indication 213148006
Congenital adrenal hyperplasia indication 237751000
Scalp psoriasis indication 238608008
Adrenogenital disorder indication 267395000 DOID:0050811
Pruritus of genital organs indication 267802000
Eruption of skin indication 271807003 DOID:0050486
Exacerbation of asthma indication 281239006
Follicular non-Hodgkin's lymphoma indication 308121000
Disorder of eye indication 371405004 DOID:5614
Primary adrenocortical insufficiency indication 373662000
Adrenal cortical hypofunction indication 386584007 DOID:10493
Erythroderma indication 399992009
Primary cutaneous T-cell lymphoma indication 400122007
Juvenile rheumatoid arthritis indication 410795001
Autoimmune hemolytic anemia indication 413603009 DOID:718
Synovitis indication 416209007 DOID:2703
Post traumatic osteoarthritis indication 699262001
Systemic Dermatomyositis indication
Diagnostic Test for Cushing's Syndrome indication
Synovitis due to Osteoarthritis indication
Transfusion Reaction Urticaria indication
Progressive Diffuse Large B-Cell Lymphoma indication
Erythroblastic Anemia indication
Pericarditis off-label use 3238004 DOID:1787
Chronic obstructive lung disease off-label use 13645005 DOID:3083
Pulmonary edema off-label use 19242006 DOID:11396
Shock off-label use 27942005
West syndrome off-label use 28055006
Vasculitis off-label use 31996006 DOID:865
Bronchitis off-label use 32398004 DOID:6132
Anaphylaxis off-label use 39579001
Eczema off-label use 43116000
Respiratory distress syndrome in the newborn off-label use 46775006
Nasal polyp off-label use 52756005
Rheumatic fever off-label use 58718002 DOID:1586
Pseudogout off-label use 60782007
Polymyalgia rheumatica off-label use 65323003 DOID:853
Chronic hepatitis off-label use 76783007 DOID:2237
Pemphigoid off-label use 86142006
Hepatic necrosis off-label use 87248009
Multiple myeloma off-label use 109989006 DOID:9538
Polyarteritis nodosa off-label use 155441006 DOID:9810
Coronavirus infection off-label use 186747009
Celiac disease off-label use 396331005 DOID:10608
Carditis off-label use 399617002
Giant cell arteritis off-label use 414341000 DOID:13375
Neonatal Bronchopulmonary Dysplasia off-label use
Prevention of Post-Extubation Laryngeal Edema off-label use
Metastatic Prostate Carcinoma off-label use
Hypercalcemia associated with Sarcoidosis off-label use
Neuroendocrine Prostate Carcinoma off-label use
Prevention of Lung Transplant Rejection off-label use
Prevention of Cardiac Transplant Rejection off-label use
Infection by Strongyloides contraindication 1214006 DOID:10955
Mycosis contraindication 3218000 DOID:1564
Gastritis contraindication 4556007 DOID:4029
Inactive tuberculosis contraindication 11999007
Peptic ulcer contraindication 13200003 DOID:750
Hypercholesterolemia contraindication 13644009
Measles contraindication 14189004 DOID:8622
Cirrhosis of liver contraindication 19943007 DOID:5082
Arginase deficiency contraindication 23501004 DOID:9278
Immunosuppression contraindication 38013005
Hypertensive disorder contraindication 38341003 DOID:10763
Infectious disease contraindication 40733004
Hypothyroidism contraindication 40930008 DOID:1459
Hypokalemia contraindication 43339004
Chronic heart failure contraindication 48447003
Cerebral malaria contraindication 53622003 DOID:14069
Tuberculosis contraindication 56717001
Congenital hyperammonemia, type I contraindication 62522004
Osteoporosis contraindication 64859006 DOID:11476
Psychotic disorder contraindication 69322001
Diabetes mellitus contraindication 73211009 DOID:9351
Hypopituitarism contraindication 74728003 DOID:9406
Hyperglycemia contraindication 80394007 DOID:4195
Open-angle glaucoma contraindication 84494001 DOID:1067
Muscle atrophy contraindication 88092000 DOID:767
Herpes simplex contraindication 88594005 DOID:8566
Bilateral cataracts contraindication 95722004
Seizure disorder contraindication 128613002
Disorder of muscle contraindication 129565002 DOID:423
Ophthalmic herpes simplex contraindication 186542001
Skin striae contraindication 201066002
Anastomosis of intestine contraindication 235407009
Telangiectasia disorder contraindication 247479008
Edema contraindication 267038008
Pathological fracture contraindication 268029009
Diverticulitis of gastrointestinal tract contraindication 271366000
Cerebral trauma contraindication 275382005
Pregnancy, function contraindication 289908002
Varicella-zoster virus infection contraindication 309465005
Osteopenia contraindication 312894000
Avascular necrosis of bone contraindication 397758007 DOID:10159
Citrullinemia contraindication 398680004 DOID:9273
Atrophoderma contraindication 399979006
Traumatic rupture of tendon contraindication 415749005
Exposure to varicella contraindication 444453009
Ornithine Carbamyltransferase Deficiency contraindication
Arginosuccinate Lyase Deficiency contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.18 acidic
pKa2 12.89 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST EC50 8.50 WOMBAT-PK CHEMBL
Annexin A1 Cytosolic other WOMBAT-PK
Androgen receptor Transcription factor Ki 4.75 DRUG MATRIX

External reference:

IDSource
4018068 VUID
N0000146409 NUI
D00407 KEGG_DRUG
4018068 VANDF
C0721647 UMLSCUI
CHEBI:6888 CHEBI
CHEMBL650 ChEMBL_ID
CHEMBL1201081 ChEMBL_ID
D008775 MESH_DESCRIPTOR_UI
DB00959 DRUGBANK_ID
7088 IUPHAR_LIGAND_ID
732 INN_ID
X4W7ZR7023 UNII
6741 PUBCHEM_CID
6902 RXNORM
1041 MMSL
5093 MMSL
7130 MMSL
d00293 MMSL
002160 NDDF
116593003 SNOMEDCT_US
27242001 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Medrol HUMAN PRESCRIPTION DRUG LABEL 1 0009-0020 TABLET 2 mg ORAL NDA 16 sections
Medrol HUMAN PRESCRIPTION DRUG LABEL 1 0009-0022 TABLET 8 mg ORAL NDA 16 sections
Medrol HUMAN PRESCRIPTION DRUG LABEL 1 0009-0049 TABLET 2 mg ORAL NDA 16 sections
Medrol HUMAN PRESCRIPTION DRUG LABEL 1 0009-0056 TABLET 4 mg ORAL NDA 16 sections
Medrol HUMAN PRESCRIPTION DRUG LABEL 1 0009-0073 TABLET 16 mg ORAL NDA 16 sections
Medrol HUMAN PRESCRIPTION DRUG LABEL 1 0009-0176 TABLET 32 mg ORAL NDA 16 sections
Methylprednisolone HUMAN PRESCRIPTION DRUG LABEL 1 0591-0790 TABLET 4 mg ORAL ANDA 12 sections
MethylPREDNISolone HUMAN PRESCRIPTION DRUG LABEL 1 0603-4593 TABLET 4 mg ORAL ANDA 13 sections
Methylprednisolone HUMAN PRESCRIPTION DRUG LABEL 1 0781-5022 TABLET 4 mg ORAL ANDA 15 sections
methylprednisolone HUMAN PRESCRIPTION DRUG LABEL 1 0904-6914 TABLET 4 mg ORAL ANDA 13 sections
METHYLPREDNISOLONE HUMAN PRESCRIPTION DRUG LABEL 1 16590-149 TABLET 4 mg ORAL ANDA 11 sections
Medrol HUMAN PRESCRIPTION DRUG LABEL 1 16590-879 TABLET 4 mg ORAL NDA 11 sections
Methylprednisolone HUMAN PRESCRIPTION DRUG LABEL 1 21695-080 TABLET 4 mg ORAL ANDA 12 sections
Methylprednisolone HUMAN PRESCRIPTION DRUG LABEL 1 33261-335 TABLET 4 mg ORAL ANDA 12 sections
METHYLPREDNISOLONE HUMAN PRESCRIPTION DRUG LABEL 1 42549-522 TABLET 4 mg ORAL ANDA 12 sections
METHYLPREDNISOLONE HUMAN PRESCRIPTION DRUG LABEL 1 42806-400 TABLET 4 mg ORAL ANDA 15 sections
Methylprednisolone HUMAN PRESCRIPTION DRUG LABEL 1 45865-104 TABLET 4 mg ORAL ANDA 15 sections
Methylprednisolone HUMAN PRESCRIPTION DRUG LABEL 1 45865-417 TABLET 4 mg ORAL ANDA 12 sections
Methylprednisolone HUMAN PRESCRIPTION DRUG LABEL 1 49999-153 TABLET 4 mg ORAL NDA 14 sections
Medrol HUMAN PRESCRIPTION DRUG LABEL 1 50090-0092 TABLET 4 mg ORAL NDA 15 sections
Methylprednisolone HUMAN PRESCRIPTION DRUG LABEL 1 50090-3094 TABLET 4 mg ORAL ANDA 12 sections
methylprednisolone HUMAN PRESCRIPTION DRUG LABEL 1 50090-3811 TABLET 4 mg ORAL ANDA 12 sections
Methylprednisolone HUMAN PRESCRIPTION DRUG LABEL 1 50436-4037 TABLET 4 mg ORAL ANDA 12 sections
METHYLPREDNISOLONE HUMAN PRESCRIPTION DRUG LABEL 1 50742-189 TABLET 4 mg ORAL ANDA 11 sections
Methylprednisolone HUMAN PRESCRIPTION DRUG LABEL 1 53002-3120 TABLET 4 mg ORAL ANDA 12 sections
Methylprednisolone HUMAN PRESCRIPTION DRUG LABEL 1 54868-2913 TABLET 4 mg ORAL ANDA 11 sections
METHYLPREDNISOLONE HUMAN PRESCRIPTION DRUG LABEL 1 54868-6624 TABLET 4 mg ORAL ANDA 12 sections
MethylPREDNISolone HUMAN PRESCRIPTION DRUG LABEL 1 55045-1259 TABLET 4 mg ORAL ANDA 17 sections
MethylPREDNISolone HUMAN PRESCRIPTION DRUG LABEL 1 55289-649 TABLET 4 mg ORAL ANDA 13 sections
METHYLPREDNISOLONE HUMAN PRESCRIPTION DRUG LABEL 1 57582-101 TABLET 4 mg ORAL ANDA 16 sections