methoxyflurane 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
halogenated compounds used as general inhalation anaesthetics	1754	76-38-0

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: methoxyflurane methoflurane methoxane methoxyfluran metofane metoxfluran metoxifluran penthrane	An inhalation anesthetic. Currently, methoxyflurane is rarely used for surgical, obstetric, or dental anesthesia. If so employed, it should be administered with NITROUS OXIDE to achieve a relatively light level of anesthesia, and a neuromuscular blocking agent given concurrently to obtain the desired degree of muscular relaxation. (From AMA Drug Evaluations Annual, 1994, p180) Molecular weight: 164.96 Formula: C3H4Cl2F2O CLOGP: 2.49 LIPINSKI: 0 HAC: 1 HDO: 0 TPSA: 9.23 ALOGS: -1.41 ROTB: 2

Molecule

Description

Molfile Inchi Smiles

Synonyms:

methoxyflurane
methoflurane
methoxane
methoxyfluran
metofane
metoxfluran
metoxifluran
penthrane

An inhalation anesthetic. Currently, methoxyflurane is rarely used for surgical, obstetric, or dental anesthesia. If so employed, it should be administered with NITROUS OXIDE to achieve a relatively light level of anesthesia, and a neuromuscular blocking agent given concurrently to obtain the desired degree of muscular relaxation. (From AMA Drug Evaluations Annual, 1994, p180)

Molecular weight: 164.96
Formula: C3H4Cl2F2O
CLOGP: 2.49
LIPINSKI: 0
HAC: 1
HDO: 0
TPSA: 9.23
ALOGS: -1.41
ROTB: 2

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA	ABBOTT

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	N02BG09	NERVOUS SYSTEM ANALGESICS OTHER ANALGESICS AND ANTIPYRETICS Other analgesics and antipyretics
MeSH PA	D000777	Anesthetics
MeSH PA	D018685	Anesthetics, Inhalation
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D002492	Central Nervous System Depressants
CHEBI has role	CHEBI:38870	inhalation anesthetics
CHEBI has role	CHEBI:50908	agente hepatotoxico
CHEBI has role	CHEBI:50909	agente nefrotoxico

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Glycine receptor subunit alpha-1	Ion channel	P23415	GLRA1_HUMAN	AGONIST				DRUGBANK	CHEMBL
GABA-A receptor; anion channel	Ion channel	O00591 O14764 P14867 P18505 P18507 P28472 P31644 P34903 P47869 P47870 P48169 P78334 Q16445 Q8N1C3 Q99928 Q9UN88	GBRP_HUMAN GBRD_HUMAN GBRA1_HUMAN GBRB1_HUMAN GBRG2_HUMAN GBRB3_HUMAN GBRA5_HUMAN GBRA3_HUMAN GBRA2_HUMAN GBRB2_HUMAN GBRA4_HUMAN GBRE_HUMAN GBRA6_HUMAN GBRG1_HUMAN GBRG3_HUMAN GBRT_HUMAN	POSITIVE MODULATOR				CHEMBL	CHEMBL

External reference:

ID	Source
4018733	VUID
N0000147038	NUI
D00544	KEGG_DRUG
4018733	VANDF
C0025688	UMLSCUI
CHEBI:6843	CHEBI
CHEMBL1341	ChEMBL_ID
DB01028	DRUGBANK_ID
D008733	MESH_DESCRIPTOR_UI
4116	PUBCHEM_CID
1048	INN_ID
7234	IUPHAR_LIGAND_ID
30905R8O7B	UNII
224935	RXNORM
2221	MMSL
5081	MMSL
d00291	MMSL
001401	NDDF
11136004	SNOMEDCT_US
1285070009	SNOMEDCT_US

Pharmaceutical products:

None