methanthelinium 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| quaternary ammonium compounds | 1736 | 5818-17-7 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
an anticholinergic agent used as an adjunctive therapy in peptic ulcer
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.15 | g | O |
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| July 3, 1951 | FDA | SHIRE |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | A03AB07 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS Synthetic anticholinergics, quaternary ammonium compounds |
| MeSH PA | D018678 | Cholinergic Agents |
| MeSH PA | D018680 | Cholinergic Antagonists |
| MeSH PA | D018727 | Muscarinic Antagonists |
| MeSH PA | D018377 | Neurotransmitter Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Peptic ulcer | indication | 13200003 | DOID:750 |
| Urinary incontinence | indication | 165232002 | |
| Gastric ulcer | indication | 397825006 | DOID:10808 |
| Irritable bowel syndrome | off-label use | 10743008 | DOID:9778 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Muscarinic acetylcholine receptor | GPCR | ANTAGONIST | KEGG DRUG | KEGG DRUG |
External reference:
| ID | Source |
|---|---|
| 4019823 | VUID |
| N0000147912 | NUI |
| 4018127 | VANDF |
| 4019823 | VANDF |
| C0025624 | UMLSCUI |
| CHEBI:6817 | CHEBI |
| CHEMBL1201264 | ChEMBL_ID |
| D00721 | KEGG_DRUG |
| CHEMBL1200988 | ChEMBL_ID |
| DB00940 | DRUGBANK_ID |
| 53-46-3 | SECONDARY_CAS_RN |
| 4097 | PUBCHEM_CID |
| 6821 | RXNORM |
| 001731 | NDDF |
| 004692 | NDDF |
| 21175009 | SNOMEDCT_US |
| 2796008 | SNOMEDCT_US |
| D000077771 | MESH_DESCRIPTOR_UI |
| 1878 | INN_ID |
| 36EI79TX7I | UNII |
Pharmaceutical products:
None