methanthelinium Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1736 5818-17-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • methanthelinium bromide
  • banthine
  • methantheline
  • methanthelin
  • methanthelinium
  • methantheline bromide
an anticholinergic agent used as an adjunctive therapy in peptic ulcer
  • Molecular weight: 340.44
  • Formula: C21H26NO3
  • CLOGP: 0.87
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 0
  • TPSA: 35.53
  • ALOGS: -6.45
  • ROTB: 7

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.15 g O

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
July 3, 1951 FDA SHIRE

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC A03AB07 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
Synthetic anticholinergics, quaternary ammonium compounds
MeSH PA D018678 Cholinergic Agents
MeSH PA D018680 Cholinergic Antagonists
MeSH PA D018727 Muscarinic Antagonists
MeSH PA D018377 Neurotransmitter Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Peptic ulcer indication 13200003 DOID:750
Urinary incontinence indication 165232002
Gastric ulcer indication 397825006 DOID:10808
Irritable bowel syndrome off-label use 10743008 DOID:9778

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Muscarinic acetylcholine receptor GPCR ANTAGONIST KEGG DRUG KEGG DRUG

External reference:

IDSource
D000077771 MESH_DESCRIPTOR_UI
4019823 VUID
N0000147912 NUI
C0025624 UMLSCUI
090519SAPF UNII
1878 INN_ID
53-46-3 SECONDARY_CAS_RN
4019823 VANDF
6821 RXNORM
2796008 SNOMEDCT_US
004692 NDDF
DB00940 DRUGBANK_ID
D00721 KEGG_DRUG
CHEBI:6817 CHEBI
CHEMBL1200988 ChEMBL_ID
CHEMBL1201264 ChEMBL_ID
4097 PUBCHEM_CID

Pharmaceutical products:

None