acetylmethadol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| analgesics | 1729 | 509-74-0 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A narcotic analgesic with a long onset and duration of action.
|
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 47 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Bocci G, Oprea TI, Benet LZ |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D000700 | Analgesics |
| MeSH PA | D000701 | Analgesics, Opioid |
| MeSH PA | D002491 | Central Nervous System Agents |
| MeSH PA | D002492 | Central Nervous System Depressants |
| MeSH PA | D009294 | Narcotics |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
| MeSH PA | D018689 | Sensory System Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Opioid dependence | indication | 75544000 | DOID:2559 |
| Suicidal thoughts | contraindication | 6471006 | |
| Alcoholism | contraindication | 7200002 | |
| Chronic disease of respiratory system | contraindication | 17097001 | |
| Mood swings | contraindication | 18963009 | |
| Disorder of gallbladder | contraindication | 39621005 | DOID:0060262 |
| Hypothyroidism | contraindication | 40930008 | DOID:1459 |
| Conduction disorder of the heart | contraindication | 44808001 | |
| General anesthesia | contraindication | 50697003 | |
| Drug AND/OR toxin-induced diarrhea | contraindication | 65979008 | |
| Benign intracranial hypertension | contraindication | 68267002 | DOID:11459 |
| Cholecystitis | contraindication | 76581006 | DOID:1949 |
| Urethral stricture | contraindication | 76618002 | |
| Decreased respiratory function | contraindication | 80954004 | |
| Injury of head | contraindication | 82271004 | |
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Procedure on urinary system | contraindication | 118677009 | |
| Disorder of gastrointestinal tract | contraindication | 119292006 | |
| Disease of liver | contraindication | 235856003 | DOID:409 |
| Benign prostatic hyperplasia | contraindication | 266569009 | |
| Lesion of brain | contraindication | 301766008 | |
| Operation on gastrointestinal tract | contraindication | 386621005 | |
| Pseudomembranous enterocolitis | contraindication | 397683000 | |
| Acute exacerbation of asthma | contraindication | 708038006 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 8.83 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Mu-type opioid receptor | GPCR | AGONIST | SCIENTIFIC LITERATURE | KEGG DRUG | |||||
| Potassium voltage-gated channel subfamily H member 2 | Ion channel | IC50 | 5.66 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| N0000006653 | NUI |
| D04973 | KEGG_DRUG |
| CHEBI:135491 | CHEBI |
| CHEMBL170179 | ChEMBL_ID |
| DB01433 | DRUGBANK_ID |
| 6814 | RXNORM |
| C0025607 | UMLSCUI |
| D008692 | MESH_DESCRIPTOR_UI |
| 10517 | PUBCHEM_CID |
| 654 | INN_ID |
| L59OC40KWJ | UNII |
Pharmaceutical products:
None