mephenytoin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
antiepileptics, hydantoin derivatives	1695	50-12-4

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

mephenytoin
DL-Mephenytoin
epiazin
fenantoin
mesantoin
mesdontoin
mesontoin
methoin
methylphenetoin
phenantoin
phenylethylmethylhydantoin

An anticonvulsant effective in tonic-clonic epilepsy (EPILEPSY, TONIC-CLONIC). It may cause blood dyscrasias.

Molecular weight: 218.26
Formula: C12H14N2O2
CLOGP: 2
LIPINSKI: 0
HAC: 4
HDO: 1
TPSA: 49.41
ALOGS: -2.35
ROTB: 2

Status: OFM

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
0.40	g	O

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Bocci G, Oprea TI, Benet LZ
S (Water solubility)	0.97 mg/mL	Bocci G, Oprea TI, Benet LZ

Approvals:

Date	Agency	Company	Orphan
Oct. 23, 1946	FDA	NOVARTIS

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	N03AB04	NERVOUS SYSTEM ANTIEPILEPTICS ANTIEPILEPTICS Hydantoin derivatives
ATC	N03AB54	NERVOUS SYSTEM ANTIEPILEPTICS ANTIEPILEPTICS Hydantoin derivatives
FDA PE	N0000008486	Decreased Central Nervous System Disorganized Electrical Activity
MeSH PA	D000927	Anticonvulsants
MeSH PA	D002491	Central Nervous System Agents
CHEBI has role	CHEBI:35623	anticonvulsants
FDA EPC	N0000175753	Anti-epileptic Agent

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Epilepsy	indication	84757009	DOID:1826
Localization-related epilepsy	indication	230381009	DOID:2234
Motor cortex epilepsy	indication	267592003
Epilepsy characterized by intractable complex partial seizures	indication	442481002

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	8.7	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Sodium channel alpha subunit	Ion channel	P35498 P35499 Q01118 Q14524 Q15858 Q99250 Q9NY46 Q9UI33 Q9UQD0 Q9Y5Y9	SCN1A_HUMAN SCN4A_HUMAN SCN7A_HUMAN SCN5A_HUMAN SCN9A_HUMAN SCN2A_HUMAN SCN3A_HUMAN SCNBA_HUMAN SCN8A_HUMAN SCNAA_HUMAN	BLOCKER				CHEMBL	CHEMBL

External reference:

ID	Source
4018756	VUID
N0000147059	NUI
D00375	KEGG_DRUG
4018756	VANDF
C0025381	UMLSCUI
CHEBI:6757	CHEBI
CHEMBL861	ChEMBL_ID
DB00532	DRUGBANK_ID
D008617	MESH_DESCRIPTOR_UI
4060	PUBCHEM_CID
7223	IUPHAR_LIGAND_ID
1463	INN_ID
R420KW629U	UNII
258358	RXNORM
1926	MMSL
5048	MMSL
d00941	MMSL
001621	NDDF
28344001	SNOMEDCT_US
417526007	SNOMEDCT_US

Pharmaceutical products:

None