mephenytoin Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antiepileptics, hydantoin derivatives 1695 50-12-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • mephenytoin
  • DL-Mephenytoin
  • epiazin
  • fenantoin
  • mesantoin
  • mesdontoin
  • mesontoin
  • methoin
  • methylphenetoin
  • phenantoin
  • phenylethylmethylhydantoin
An anticonvulsant effective in tonic-clonic epilepsy (EPILEPSY, TONIC-CLONIC). It may cause blood dyscrasias.
  • Molecular weight: 218.26
  • Formula: C12H14N2O2
  • CLOGP: 2
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 49.41
  • ALOGS: -2.35
  • ROTB: 2

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.40 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Hosey CM, Chan R, Benet LZ

Approvals:

DateAgencyCompanyOrphan
Oct. 23, 1946 FDA NOVARTIS

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC N03AB04 NERVOUS SYSTEM
ANTIEPILEPTICS
ANTIEPILEPTICS
Hydantoin derivatives
ATC N03AB54 NERVOUS SYSTEM
ANTIEPILEPTICS
ANTIEPILEPTICS
Hydantoin derivatives
FDA PE N0000008486 Decreased Central Nervous System Disorganized Electrical Activity
FDA EPC N0000175753 Anti-epileptic Agent
MeSH PA D000927 Anticonvulsants
MeSH PA D002491 Central Nervous System Agents
CHEBI has role CHEBI:35623 antiepileptic

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Epilepsy indication 84757009 DOID:1826
Localization-related epilepsy indication 230381009 DOID:2234
Motor cortex epilepsy indication 267592003
Epilepsy characterized by intractable complex partial seizures indication 442481002

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.7 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sodium channel alpha subunit Ion channel BLOCKER CHEMBL CHEMBL

External reference:

IDSource
4018756 VUID
N0000147059 NUI
D00375 KEGG_DRUG
4018756 VANDF
C0031507 UMLSCUI
CHEBI:6757 CHEBI
CHEMBL861 ChEMBL_ID
D008617 MESH_DESCRIPTOR_UI
DB00532 DRUGBANK_ID
4060 PUBCHEM_CID
7223 IUPHAR_LIGAND_ID
1463 INN_ID
R420KW629U UNII
258358 RXNORM
1926 MMSL
5048 MMSL
d00941 MMSL
001621 NDDF
28344001 SNOMEDCT_US
417526007 SNOMEDCT_US

Pharmaceutical products:

None