mephentermine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| anorexics | 1694 | 100-92-5 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A sympathomimetic agent with specificity for alpha-1 adrenergic receptors. It is used to maintain BLOOD PRESSURE in hypotensive states such as following SPINAL ANESTHESIA.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 30 | mg | P |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| fu (Fraction unbound in plasma) | 0.87 % | Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Dec. 29, 1951 | FDA | BAXTER HLTHCARE CORP |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | C01CA11 | CARDIOVASCULAR SYSTEM CARDIAC THERAPY CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES Adrenergic and dopaminergic agents |
| MeSH PA | D018663 | Adrenergic Agents |
| MeSH PA | D000322 | Adrenergic Agonists |
| MeSH PA | D058646 | Adrenergic alpha-1 Receptor Agonists |
| MeSH PA | D000316 | Adrenergic alpha-Agonists |
| MeSH PA | D002317 | Cardiovascular Agents |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
| MeSH PA | D013566 | Sympathomimetics |
| MeSH PA | D014662 | Vasoconstrictor Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Low blood pressure | indication | 45007003 | |
| Prevention of Hypotension During Spinal Anesthesia | indication | ||
| Hypotension Secondary to Spinal Anesthesia | indication |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 9.85 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Alpha-1A adrenergic receptor | GPCR | AGONIST | DRUGBANK | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4019814 | VUID |
| N0000147903 | NUI |
| D08180 | KEGG_DRUG |
| 4018029 | VANDF |
| 4019814 | VANDF |
| C0025380 | UMLSCUI |
| CHEBI:6755 | CHEBI |
| CHEMBL1201234 | ChEMBL_ID |
| DB01365 | DRUGBANK_ID |
| CHEMBL3184799 | ChEMBL_ID |
| D008616 | MESH_DESCRIPTOR_UI |
| 3677 | PUBCHEM_CID |
| 495 | INN_ID |
| 7222 | IUPHAR_LIGAND_ID |
| 1212-72-2 | SECONDARY_CAS_RN |
| TEZ91L71V4 | UNII |
| 6756 | RXNORM |
| 5047 | MMSL |
| d00701 | MMSL |
| 001830 | NDDF |
| 004736 | NDDF |
| 1173092000 | SNOMEDCT_US |
| 31799007 | SNOMEDCT_US |
| 38648002 | SNOMEDCT_US |
| CHEMBL1200996 | ChEMBL_ID |
Pharmaceutical products:
None