medrysone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
corticosteroids, except prednisolone derivatives 1662 2668-66-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • medrysone
  • hydroxymesterone
  • medrifar
  • medrocort
  • Molecular weight: 344.50
  • Formula: C22H32O3
  • CLOGP: 3.36
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 1
  • TPSA: 54.37
  • ALOGS: -4.01
  • ROTB: 1
  • Status: OFM
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Nov. 28, 1969 FDA ALLERGAN

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC S01BA08 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS
Corticosteroids, plain
FDA MoA N0000175450 Corticosteroid Hormone Receptor Agonists
FDA EPC N0000175576 Corticosteroid
MeSH PA D005938 Glucocorticoids
MeSH PA D006728 Hormones

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Cyclitis indication 17657000
Iritis indication 65074000 DOID:1406
Iridocyclitis indication 77971008
Corneal abrasion indication 85848002
Corneal ulcer indication 91514001 DOID:8463
Uveitis indication 128473001 DOID:13141
Punctate keratopathy indication 246936005
Herpes zoster keratitis indication 397573005
Rosacea indication 398909004 DOID:8881
Allergic conjunctivitis indication 473460002 DOID:11204
Post-Op Ocular Inflammation indication
Otitis externa off-label use 3135009
Allergic otitis externa off-label use 405821001
Otitis Externa Seborrhea off-label use
Otitis Externa Eczema off-label use




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST CHEMBL CHEMBL

External reference:

IDSource
4018206 VUID
N0000146540 NUI
D02289 KEGG_DRUG
4018206 VANDF
C0065865 UMLSCUI
CHEBI:34829 CHEBI
CHEMBL1201173 ChEMBL_ID
DB00253 DRUGBANK_ID
C100283 MESH_SUPPLEMENTAL_RECORD_UI
247839 PUBCHEM_CID
7086 IUPHAR_LIGAND_ID
2039 INN_ID
D2UFC189XF UNII
29439 RXNORM
5033 MMSL
002196 NDDF
387403005 SNOMEDCT_US
47140009 SNOMEDCT_US

Pharmaceutical products:

None