aminohippuric acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 165 | 61-78-9 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
The glycine amide of 4-aminobenzoic acid. Its sodium salt is used as a diagnostic aid to measure effective renal plasma flow (ERPF) and excretory capacity.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Dec. 30, 1944 | FDA | MERCK |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | V04CH30 | VARIOUS DIAGNOSTIC AGENTS OTHER DIAGNOSTIC AGENTS Tests for renal function and ureteral injuries |
| MeSH PA | D007202 | Indicators and Reagents |
| CHEBI has role | CHEBI:33295 | diagnostic aid |
| CHEBI has role | CHEBI:83056 | Daphnia magna metabolites |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Decreased cardiac function | contraindication | 43650005 | |
| Decompensated cardiac failure | contraindication | 195111005 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 3.84 | acidic |
| pKa2 | 12.82 | acidic |
| pKa3 | 2.76 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Solute carrier family 22 member 6 | Transporter | Ki | 5.22 | CHEMBL | |||||
| Solute carrier family 22 member 6 | Transporter | Ki | 5.03 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| N0000011185 | NUI |
| D06890 | KEGG_DRUG |
| 94-16-6 | SECONDARY_CAS_RN |
| 203194 | RXNORM |
| C0030123 | UMLSCUI |
| CHEBI:104011 | CHEBI |
| CHEMBL463 | ChEMBL_ID |
| DB00345 | DRUGBANK_ID |
| 2148 | PUBCHEM_CID |
| 4810 | IUPHAR_LIGAND_ID |
| Y79XT83BJ9 | UNII |
| 4171 | MMSL |
| 6418 | MMSL |
| d04085 | MMSL |
| 43462003 | SNOMEDCT_US |
| 48618003 | SNOMEDCT_US |
| 786262001 | SNOMEDCT_US |
| D010130 | MESH_DESCRIPTOR_UI |
| CHEMBL1200365 | ChEMBL_ID |
| 4017967 | VANDF |
| 4019605 | VANDF |
| 002340 | NDDF |
| 004885 | NDDF |
Pharmaceutical products:
None