malathion 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
insecticides, anthelminthics, pesticides etc., phosphorous derivatives	1626	121-75-5

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

malathion
carbetovur
carbetox
carbofos
carbophos
cimexan
ethiolacar
malathine
malathyne
sadofos

A wide spectrum aliphatic organophosphate insecticide widely used for both domestic and commercial agricultural purposes.

Molecular weight: 330.35
Formula: C10H19O6PS2
CLOGP: 2.48
LIPINSKI: 0
HAC: 6
HDO: 0
TPSA: 71.06
ALOGS: -3.30
ROTB: 11

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Aug. 2, 1982	FDA	TARO PHARMS NORTH

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	P03AX03	ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS ECTOPARASITICIDES, INCL. SCABICIDES, INSECTICIDES AND REPELLENTS ECTOPARASITICIDES, INCL. SCABICIDES Other ectoparasiticides, incl. scabicides
FDA MoA	N0000000177	Cholinesterase Inhibitors
MeSH PA	D018678	Cholinergic Agents
MeSH PA	D002800	Cholinesterase Inhibitors
MeSH PA	D004791	Enzyme Inhibitors
MeSH PA	D007306	Insecticides
MeSH PA	D018377	Neurotransmitter Agents
MeSH PA	D010575	Pesticides
CHEBI has role	CHEBI:33286	agricultural chemicals
CHEBI has role	CHEBI:37733	EC 3.1.1.8 inhibitor
CHEBI has role	CHEBI:38462	acetylcholinesterase inhibitors
CHEBI has role	CHEBI:38706	pediculicides
CHEBI has role	CHEBI:73333	scabicides
CHEBI has role	CHEBI:136644	pro-insecticides
FDA EPC	N0000175723	Cholinesterase Inhibitor

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Pediculosis capitis	indication	81000006	DOID:5501
Skin irritation	contraindication	367466007

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

Formulation strength	Trade name	Applicant	Application number	Approval date	Type	Dose form	Route	Patent number	Patent expiration date	Patent use
0.5% Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	OVIDE	TARO	N018613	Aug. 2, 1982	DISCN	LOTION	TOPICAL	7560445	Feb. 1, 2027	TREATMENT OF PATIENTS INFECTED WITH PEDICULUS HUMANUS CAPITIS (HEAD LICE AND THEIR OVA) OF THE SCALP HAIR

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Melatonin receptor type 1A	GPCR	P48039	MTR1A_HUMAN		Ki	9.54		PDSP
Acetylcholinesterase	Enzyme		A2PZ98_9NEOP	INHIBITOR				CHEMBL	CHEMBL

External reference:

ID	Source
4018435	VUID
N0000146761	NUI
D00534	KEGG_DRUG
4018435	VANDF
C0024547	UMLSCUI
CHEBI:6651	CHEBI
CHEMBL1200468	ChEMBL_ID
DB00772	DRUGBANK_ID
D008294	MESH_DESCRIPTOR_UI
4004	PUBCHEM_CID
U5N7SU872W	UNII
6606	RXNORM
165167	MMSL
8231	MMSL
002995	NDDF
333071000	SNOMEDCT_US
87205003	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Ovide	HUMAN PRESCRIPTION DRUG LABEL	1	51672-5293	LOTION	0.00 g	TOPICAL	ANDA	21 sections
Malathion	HUMAN PRESCRIPTION DRUG LABEL	1	51672-5294	LOTION	0.00 g	TOPICAL	ANDA	21 sections
Malathion	HUMAN PRESCRIPTION DRUG LABEL	1	68022-0001	LOTION	0.01 g	TOPICAL	ANDA	19 sections
Malathion	HUMAN PRESCRIPTION DRUG LABEL	1	68022-0001	LOTION	0.01 g	TOPICAL	ANDA	19 sections