All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

loxoprofen 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
anti-inflammatory agents, ibuprofen derivatives	1615	68767-14-6

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: loxoprofen sodium hydrate loxonin loxoprofen loxoprofen sodium sodium loxoprofen	Molecular weight: 246.31 Formula: C15H18O3 CLOGP: 1.97 LIPINSKI: 0 HAC: 3 HDO: 1 TPSA: 54.37 ALOGS: -3.57 ROTB: 4

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Jan. 23, 2006	PMDA	Lead Chemical Co., Ltd.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Platelet count decreased	320.53	19.16	225	11882	115897	63361018
Interstitial lung disease	315.18	19.16	177	11930	61731	63415184
Hepatic function abnormal	224.36	19.16	119	11988	37023	63439892
Malignant neoplasm progression	172.06	19.16	135	11972	81986	63394929
Neutrophil count decreased	161.60	19.16	112	11995	56294	63420621
Osteonecrosis of jaw	132.86	19.16	83	12024	35040	63441875
White blood cell count decreased	128.41	19.16	145	11962	138959	63337956
Anaemia	126.02	19.16	211	11896	293219	63183696
Fatigue	109.72	19.16	19	12088	888009	62588906
Disseminated intravascular coagulation	106.44	19.16	58	12049	18993	63457922
Drug eruption	103.97	19.16	66	12041	28628	63448287
Drug ineffective	96.07	19.16	40	12067	1044725	62432190
Cerebral infarction	89.16	19.16	56	12051	23837	63453078
Decreased appetite	77.83	19.16	157	11950	250895	63226020
Spinal compression fracture	75.69	19.16	42	12065	14241	63462674
Gastrointestinal perforation	69.98	19.16	26	12081	3465	63473450
Erythema multiforme	68.24	19.16	35	12072	10134	63466781
Pyrexia	66.85	19.16	219	11888	470259	63006656
Enterocolitis	64.45	19.16	31	12076	7827	63469088
Altered state of consciousness	62.74	19.16	46	12061	25184	63451731
Upper respiratory tract inflammation	62.60	19.16	22	12085	2501	63474414
Febrile neutropenia	61.41	19.16	93	12014	118356	63358559
Drug-induced liver injury	61.11	19.16	55	12052	40167	63436748
Cardiac failure	61.07	19.16	80	12027	89062	63387853
Renal impairment	55.48	19.16	76	12031	88279	63388636
Haemorrhage subcutaneous	51.78	19.16	20	12087	2963	63473952
Joint swelling	50.52	19.16	3	12104	327663	63149252
Pneumonia bacterial	47.88	19.16	27	12080	9438	63467477
Drug intolerance	47.06	19.16	3	12104	308658	63168257
Iron deficiency anaemia	46.49	19.16	35	12072	19934	63456981
Liver disorder	46.11	19.16	54	12053	53633	63423282
Enteritis infectious	43.24	19.16	16	12091	2108	63474807
Pain	42.89	19.16	47	12060	740581	62736334
Hypoalbuminaemia	42.36	19.16	27	12080	11778	63465137
Femoral neck fracture	42.26	19.16	24	12083	8499	63468416
Ileus	41.55	19.16	29	12078	14696	63462219
Drug hypersensitivity	39.62	19.16	6	12101	310681	63166234
Aspartate aminotransferase increased	37.34	19.16	64	12043	90213	63386702
Fulminant type 1 diabetes mellitus	37.14	19.16	10	12097	465	63476450
Peripheral swelling	36.64	19.16	4	12103	265938	63210977
Swelling	35.85	19.16	5	12102	275373	63201542
Peritonitis	35.41	19.16	28	12079	17126	63459789
Paronychia	34.03	19.16	18	12089	5547	63471368
Lymphocyte count decreased	33.90	19.16	35	12072	30222	63446693
Herpes zoster	32.20	19.16	57	12050	82405	63394510
Ascites	31.74	19.16	39	12068	40689	63436226
Pharyngitis	31.49	19.16	28	12079	20115	63456800
Asteatosis	31.11	19.16	6	12101	59	63476856
Alanine aminotransferase increased	30.99	19.16	64	12043	103706	63373209
Colon cancer	29.15	19.16	20	12087	9858	63467057
Heat illness	29.09	19.16	7	12100	206	63476709
Hypopituitarism	28.44	19.16	10	12097	1138	63475777
Gastroenteritis	28.43	19.16	30	12077	26560	63450355
Pulmonary alveolar haemorrhage	28.26	19.16	15	12092	4653	63472262
Stevens-Johnson syndrome	28.20	19.16	29	12078	24921	63451994
Breast cancer	27.94	19.16	40	12067	48343	63428572
Weight increased	27.19	19.16	8	12099	260784	63216131
Malignant pleural effusion	26.71	19.16	12	12095	2594	63474321
Subarachnoid haemorrhage	26.70	19.16	22	12085	14261	63462654
Purpura	26.60	19.16	20	12087	11365	63465550
Lymphangiosis carcinomatosa	26.20	19.16	10	12097	1435	63475480
Concomitant disease aggravated	25.83	19.16	18	12089	9094	63467821
Haemoglobin decreased	25.45	19.16	73	12034	145412	63331503
Pneumocystis jirovecii pneumonia	25.42	19.16	23	12084	16891	63460024
Eczema	25.29	19.16	31	12076	32260	63444655
Tumour haemorrhage	25.02	19.16	10	12097	1621	63475294
Pleural effusion	24.96	19.16	55	12052	93155	63383760
Blood pressure decreased	24.17	19.16	44	12063	64978	63411937
Duodenal ulcer haemorrhage	24.15	19.16	11	12096	2456	63474459
Hyperuricaemia	23.65	19.16	14	12093	5356	63471559
Atypical femur fracture	23.64	19.16	14	12093	5358	63471557
Blood bilirubin increased	23.37	19.16	32	12075	37108	63439807
Physical deconditioning	23.37	19.16	8	12099	841	63476074
Enterocolitis viral	22.62	19.16	6	12101	263	63476652
Liver abscess	22.62	19.16	11	12096	2843	63474072
Hypersensitivity	22.52	19.16	14	12093	292671	63184244
Alopecia	22.27	19.16	19	12088	337517	63139398
Osteomyelitis	22.04	19.16	26	12081	25994	63450921
Melaena	21.94	19.16	28	12079	30337	63446578
Stomatitis	21.78	19.16	67	12040	138658	63338257
Lymphoproliferative disorder	21.46	19.16	11	12096	3179	63473736
Aortitis	21.44	19.16	8	12099	1079	63475836
Cancer pain	21.41	19.16	11	12096	3194	63473721
Subacute hepatic failure	21.26	19.16	5	12102	133	63476782
Delirium	21.11	19.16	36	12071	50505	63426410
Sinusitis	20.15	19.16	9	12098	226644	63250271
Malaise	19.59	19.16	141	11966	415813	63061102
Gamma-glutamyltransferase increased	19.45	19.16	28	12079	34003	63442912
Pneumonia	19.35	19.16	151	11956	456616	63020299
Asthenia	19.33	19.16	27	12080	383577	63093338
Familial mediterranean fever	19.18	19.16	4	12103	60	63476855

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Interstitial lung disease	455.17	17.50	272	10682	65010	34880967
Malignant neoplasm progression	233.16	17.50	204	10750	87842	34858135
Platelet count decreased	206.43	17.50	219	10735	119498	34826479
Hepatic function abnormal	202.64	17.50	142	10812	44221	34901756
White blood cell count decreased	116.01	17.50	146	10808	95299	34850678
Liver disorder	96.30	17.50	81	10873	32916	34913061
Neutrophil count decreased	94.04	17.50	97	10857	51007	34894970
Decreased appetite	84.89	17.50	171	10783	166221	34779756
Osteonecrosis of jaw	65.11	17.50	50	10904	17839	34928138
Drug ineffective	62.27	17.50	33	10921	456718	34489259
Stomatitis	61.28	17.50	71	10883	42443	34903534
Fatigue	56.30	17.50	23	10931	370630	34575347
Disseminated intravascular coagulation	54.43	17.50	49	10905	21767	34924210
Drug eruption	52.24	17.50	46	10908	19852	34926125
Renal impairment	49.10	17.50	98	10856	94415	34851562
Toxicity to various agents	47.93	17.50	4	10950	200358	34745619
Pyrexia	45.34	17.50	215	10739	332798	34613179
Radiation pneumonitis	44.55	17.50	20	10934	2620	34943357
Asthenia	42.76	17.50	12	10942	245239	34700738
Cholangitis	42.36	17.50	29	10925	8660	34937317
Anaemia	41.98	17.50	164	10790	233171	34712806
Drug-induced liver injury	41.27	17.50	48	10906	28784	34917193
Gastric ulcer haemorrhage	38.47	17.50	23	10931	5443	34940534
Delirium	37.78	17.50	57	10897	43934	34902043
Malaise	37.02	17.50	135	10819	185690	34760287
Aspartate aminotransferase increased	34.83	17.50	70	10884	67713	34878264
Gastrointestinal perforation	34.54	17.50	19	10935	3844	34942133
Altered state of consciousness	34.25	17.50	39	10915	22854	34923123
Confusional state	34.12	17.50	3	10951	144157	34801820
Erythema multiforme	33.28	17.50	25	10929	8624	34937353
Gastric ulcer	32.96	17.50	32	10922	15618	34930359
Upper respiratory tract inflammation	31.96	17.50	14	10940	1730	34944247
Hypothyroidism	30.24	17.50	35	10919	20867	34925110
Cerebral infarction	30.12	17.50	40	10914	27415	34918562
Lymphangiosis carcinomatosa	29.21	17.50	11	10943	921	34945056
Adrenocorticotropic hormone deficiency	29.04	17.50	11	10943	936	34945041
Non-small cell lung cancer	28.83	17.50	17	10937	3923	34942054
Pneumonia aspiration	28.72	17.50	49	10905	41854	34904123
Duodenal ulcer	27.34	17.50	24	10930	10308	34935669
Adrenal insufficiency	26.40	17.50	27	10927	14020	34931957
Pneumonia bacterial	26.37	17.50	25	10929	11847	34934130
Enterocolitis	26.10	17.50	21	10933	8005	34937972
Hyperuricaemia	26.06	17.50	21	10933	8022	34937955
Death	25.75	17.50	54	10900	397995	34547982
C-reactive protein increased	25.58	17.50	54	10900	54044	34891933
Blood bilirubin increased	25.21	17.50	44	10910	38252	34907725
Product dose omission issue	24.61	17.50	4	10950	119707	34826270
Alanine aminotransferase increased	23.59	17.50	67	10887	80748	34865229
Immune-mediated enterocolitis	22.93	17.50	13	10941	2786	34943191
Rash	22.73	17.50	133	10821	222619	34723358
Palmar-plantar erythrodysaesthesia syndrome	22.43	17.50	27	10927	16768	34929209
Hypoalbuminaemia	22.15	17.50	23	10931	12151	34933826
Prescribed underdose	22.14	17.50	20	10934	8913	34937064
Pharyngitis	22.12	17.50	19	10935	7925	34938052
Thrombophlebitis migrans	21.52	17.50	6	10948	191	34945786
Anxiety	21.17	17.50	3	10951	99425	34846552
Hepatocellular carcinoma	20.99	17.50	18	10936	7491	34938486
Cancer pain	20.79	17.50	12	10942	2660	34943317
Hypotension	20.05	17.50	24	10930	221625	34724352
Blood lactate dehydrogenase increased	20.02	17.50	30	10924	22960	34923017
Infective spondylitis	19.90	17.50	6	10948	253	34945724
Peritonitis	19.75	17.50	25	10929	16340	34929637
Haemorrhage subcutaneous	19.60	17.50	11	10943	2313	34943664
Duodenal perforation	19.42	17.50	9	10945	1269	34944708
Rhinitis allergic	19.32	17.50	12	10942	3038	34942939
Pneumonia	19.04	17.50	185	10769	362442	34583535
Eosinophil count increased	18.94	17.50	18	10936	8554	34937423
Colon cancer	18.85	17.50	18	10936	8603	34937374
Dyspnoea	18.30	17.50	59	10895	376723	34569254
Constipation	18.19	17.50	88	10866	136894	34809083
Paralysis recurrent laryngeal nerve	18.11	17.50	4	10950	47	34945930
Spinal compression fracture	17.77	17.50	16	10938	7100	34938877

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Interstitial lung disease	734.23	16.04	441	23196	112159	79608592
Platelet count decreased	512.64	16.04	439	23198	194225	79526526
Malignant neoplasm progression	408.04	16.04	331	23306	135659	79585092
Hepatic function abnormal	401.45	16.04	257	23380	72850	79647901
White blood cell count decreased	244.87	16.04	290	23347	187998	79532753
Neutrophil count decreased	236.75	16.04	207	23430	93752	79626999
Osteonecrosis of jaw	179.70	16.04	128	23509	43098	79677653
Fatigue	159.56	16.04	40	23597	929687	78791064
Disseminated intravascular coagulation	153.28	16.04	108	23529	35734	79685017
Decreased appetite	152.29	16.04	322	23315	342096	79378655
Anaemia	147.88	16.04	373	23264	444642	79276109
Drug ineffective	146.80	16.04	69	23568	1080844	78639907
Drug eruption	137.94	16.04	110	23527	43825	79676926
Liver disorder	129.49	16.04	132	23505	72285	79648466
Pyrexia	100.47	16.04	432	23205	678277	79042474
Gastrointestinal perforation	98.04	16.04	44	23593	6093	79714658
Cerebral infarction	97.96	16.04	92	23545	45584	79675167
Renal impairment	96.49	16.04	170	23467	157613	79563138
Erythema multiforme	91.67	16.04	60	23577	17591	79703160
Upper respiratory tract inflammation	87.79	16.04	36	23601	3999	79716752
Drug-induced liver injury	86.00	16.04	102	23535	66015	79654736
Enterocolitis	81.95	16.04	52	23585	14460	79706291
Spinal compression fracture	81.67	16.04	55	23582	16903	79703848
Altered state of consciousness	80.34	16.04	81	23556	43741	79677010
Confusional state	77.79	16.04	4	23633	317993	79402758
Toxicity to various agents	76.32	16.04	16	23621	421524	79299227
Stomatitis	67.34	16.04	140	23497	146617	79574134
Asthenia	67.12	16.04	34	23603	511655	79209096
Pneumonia bacterial	66.27	16.04	51	23586	19280	79701471
Haemorrhage subcutaneous	62.84	16.04	30	23607	4779	79715972
Aspartate aminotransferase increased	62.14	16.04	131	23506	138510	79582241
Joint swelling	61.17	16.04	7	23630	288639	79432112
Hypoalbuminaemia	59.83	16.04	50	23587	21247	79699504
Febrile neutropenia	57.93	16.04	175	23462	230824	79489927
Completed suicide	57.34	16.04	4	23633	245763	79474988
Drug intolerance	56.99	16.04	6	23631	264113	79456638
Drug hypersensitivity	56.92	16.04	10	23627	298906	79421845
Cardiac failure	55.64	16.04	134	23503	154708	79566043
Product dose omission issue	55.04	16.04	5	23632	247532	79473219
Pain	54.24	16.04	78	23559	703724	79017027
Cholangitis	53.44	16.04	38	23599	12738	79708013
Lymphangiosis carcinomatosa	53.01	16.04	21	23616	2133	79718618
Radiation pneumonitis	52.82	16.04	25	23612	3908	79716843
Delirium	52.74	16.04	92	23545	84535	79636216
Pharyngitis	51.70	16.04	47	23590	22328	79698423
Peripheral swelling	51.37	16.04	9	23628	269608	79451143
Peritonitis	49.88	16.04	51	23586	27985	79692766
Hyperuricaemia	49.14	16.04	35	23602	11764	79708987
Colon cancer	46.92	16.04	37	23600	14486	79706265
Gastric ulcer	46.89	16.04	54	23583	33851	79686900
Non-small cell lung cancer	46.77	16.04	27	23610	6333	79714418
Blood bilirubin increased	46.57	16.04	76	23561	66156	79654595
Fulminant type 1 diabetes mellitus	45.58	16.04	17	23620	1466	79719285
Alanine aminotransferase increased	44.39	16.04	127	23510	162443	79558308
Enteritis infectious	44.16	16.04	21	23616	3317	79717434
Adrenocorticotropic hormone deficiency	43.02	16.04	16	23621	1369	79719382
Femoral neck fracture	42.46	16.04	30	23607	9954	79710797
Hypotension	42.21	16.04	41	23596	440276	79280475
Ileus	41.84	16.04	45	23592	26166	79694585
Swelling	41.79	16.04	7	23630	216704	79504047
Malaise	41.15	16.04	267	23370	489602	79231149
Hypopituitarism	40.78	16.04	20	23617	3379	79717372
Dyspnoea	40.74	16.04	125	23512	856900	78863851
Pneumonia	40.65	16.04	334	23303	659912	79060839
Cancer pain	40.53	16.04	23	23614	5222	79715529
Gastric ulcer haemorrhage	40.43	16.04	28	23609	8999	79711752
Tumour haemorrhage	39.85	16.04	21	23616	4123	79716628
Herpes zoster	38.30	16.04	85	23552	92998	79627753
Arthropathy	38.25	16.04	4	23633	177107	79543644
Pleural effusion	38.23	16.04	112	23525	145150	79575601
Pneumonia aspiration	38.13	16.04	70	23567	66897	79653854
Iron deficiency anaemia	37.38	16.04	42	23595	25630	79695121
Therapeutic product effect decreased	37.26	16.04	3	23634	163860	79556891
Adrenal insufficiency	37.10	16.04	44	23593	28443	79692308
Drug abuse	36.94	16.04	3	23634	162688	79558063
Asteatosis	36.06	16.04	8	23629	102	79720649
Weight increased	35.47	16.04	19	23618	277367	79443384
Malignant pleural effusion	35.00	16.04	18	23619	3362	79717389
Hypersensitivity	34.97	16.04	17	23620	262222	79458529
Renal disorder	34.72	16.04	52	23585	42053	79678698
Pulmonary alveolar haemorrhage	34.48	16.04	28	23609	11429	79709322
Constipation	34.11	16.04	170	23467	282880	79437871
Pneumocystis jirovecii pneumonia	34.02	16.04	45	23592	32463	79688288
Gastroenteritis	33.86	16.04	46	23591	34036	79686715
Pain in extremity	33.71	16.04	35	23602	364503	79356248
Stevens-Johnson syndrome	33.20	16.04	49	23588	39117	79681634
Haemoglobin decreased	32.34	16.04	141	23496	221978	79498773
Duodenal ulcer	31.36	16.04	31	23606	16338	79704413
Gamma-glutamyltransferase increased	30.92	16.04	57	23580	54623	79666128
Eczema	30.28	16.04	48	23589	40770	79679981
Lymphocyte count decreased	30.22	16.04	52	23585	47237	79673514
Paronychia	29.87	16.04	22	23615	7786	79712965
Duodenal perforation	29.76	16.04	14	23623	2158	79718593
Immune-mediated enterocolitis	29.01	16.04	18	23619	4812	79715939
Anxiety	28.98	16.04	19	23618	248493	79472258
Hypothyroidism	28.86	16.04	54	23583	52338	79668413
C-reactive protein increased	28.84	16.04	94	23543	128933	79591818
Weight decreased	28.66	16.04	38	23599	355160	79365591
Hypocalcaemia	28.18	16.04	52	23585	49872	79670879
Cerebrovascular accident	27.84	16.04	6	23631	155286	79565465
Injection site dermatitis	27.78	16.04	5	23632	19	79720732
Liver abscess	27.64	16.04	19	23618	6035	79714716
Blood lactate dehydrogenase increased	27.60	16.04	45	23592	39125	79681626
Haemolytic anaemia	27.40	16.04	30	23607	17790	79702961
Hepatocellular carcinoma	27.05	16.04	22	23615	8999	79711752
Rhinitis allergic	26.84	16.04	25	23612	12244	79708507
Pneumothorax	26.29	16.04	37	23600	28286	79692465
Palmar-plantar erythrodysaesthesia syndrome	26.01	16.04	40	23597	33094	79687657
Paraesthesia	25.76	16.04	10	23627	176313	79544438
Prescribed underdose	25.12	16.04	37	23600	29477	79691274
Thrombophlebitis migrans	24.94	16.04	8	23629	439	79720312
Small intestine ulcer	24.90	16.04	9	23628	710	79720041
Syncope	24.89	16.04	11	23626	179438	79541313
Dyslalia	24.81	16.04	10	23627	1062	79719689
Arthralgia	24.62	16.04	87	23550	571716	79149035
Headache	24.61	16.04	105	23532	653667	79067084
Off label use	24.55	16.04	163	23474	907052	78813699
Breast cancer	24.06	16.04	39	23598	33742	79687009
Infective spondylitis	23.84	16.04	8	23629	506	79720245
KL-6 increased	23.05	16.04	6	23631	155	79720596
Heart rate increased	23.04	16.04	4	23633	120720	79600031
Heat illness	22.94	16.04	8	23629	569	79720182
Blood urea increased	22.88	16.04	47	23590	48743	79672008
Skin erosion	22.81	16.04	15	23622	4430	79716321
Eczema asteatotic	22.55	16.04	8	23629	598	79720153
Ascites	22.55	16.04	61	23576	75501	79645250
Blood creatine phosphokinase increased	22.44	16.04	56	23581	66034	79654717
Melaena	22.17	16.04	53	23584	60837	79659914
Tumour necrosis	22.14	16.04	11	23626	1911	79718840
Product use in unapproved indication	22.06	16.04	25	23612	250334	79470417
Sudden hearing loss	21.89	16.04	11	23626	1958	79718793
Wound	21.85	16.04	4	23633	116175	79604576
Enterocolitis viral	21.79	16.04	7	23630	386	79720365
Diverticulum intestinal haemorrhagic	21.72	16.04	14	23623	3997	79716754
Concomitant disease aggravated	21.71	16.04	23	23614	13144	79707607
Small intestinal perforation	21.62	16.04	13	23624	3284	79717467
Rash	21.60	16.04	264	23373	578094	79142657
Chronic gastritis	21.54	16.04	14	23623	4054	79716697
Large intestine perforation	21.49	16.04	24	23613	14543	79706208
Cholangitis acute	21.38	16.04	10	23627	1522	79719229
Pyelonephritis	20.99	16.04	28	23609	20360	79700391
Chest pain	20.98	16.04	32	23605	282272	79438479
Atypical femur fracture	20.71	16.04	15	23622	5174	79715577
Death	20.69	16.04	92	23545	566422	79154329
Duodenal ulcer haemorrhage	20.49	16.04	17	23620	7146	79713605
Rheumatoid arthritis	20.42	16.04	19	23618	208451	79512300
Pulmonary toxicity	20.31	16.04	22	23615	12892	79707859
Periodontitis	20.26	16.04	14	23623	4482	79716269
Blood pressure decreased	20.05	16.04	70	23567	99396	79621355
Shock haemorrhagic	19.81	16.04	27	23610	20033	79700718
Lymphoproliferative disorder	19.65	16.04	15	23622	5600	79715151
Blood alkaline phosphatase increased	19.60	16.04	52	23585	63612	79657139
Musculoskeletal stiffness	19.57	16.04	14	23623	174994	79545757
Osteomyelitis	19.52	16.04	35	23602	32830	79687921
Metastases to liver	19.23	16.04	32	23605	28282	79692469
Sinusitis	18.94	16.04	18	23619	195483	79525268
Memory impairment	18.68	16.04	5	23632	111729	79609022
Oculomucocutaneous syndrome	18.64	16.04	6	23631	333	79720418
Discomfort	18.55	16.04	7	23630	125610	79595141
Physical deconditioning	18.53	16.04	10	23627	2060	79718691
Aortitis	18.48	16.04	9	23628	1498	79719253
Alopecia	18.39	16.04	25	23612	231330	79489421
Meningitis	18.08	16.04	18	23619	9564	79711187
Immune-mediated hepatic disorder	18.00	16.04	9	23628	1585	79719166
Mobility decreased	17.73	16.04	7	23630	122168	79598583
Familial mediterranean fever	17.57	16.04	5	23632	182	79720569
Lupus nephritis	17.53	16.04	11	23626	2997	79717754
Nephrotic syndrome	17.51	16.04	19	23618	11155	79709596
Dermatitis acneiform	17.45	16.04	18	23619	9975	79710776
Product use issue	17.37	16.04	22	23615	209800	79510951
Malignant ascites	17.31	16.04	8	23629	1184	79719567
Hyperhidrosis	17.09	16.04	12	23625	151480	79569271
Subarachnoid haemorrhage	17.09	16.04	28	23609	24437	79696314
General physical health deterioration	17.01	16.04	35	23602	275203	79445548
Pleurisy	16.74	16.04	18	23619	10457	79710294
Wheezing	16.42	16.04	7	23630	116657	79604094
Loss of personal independence in daily activities	16.39	16.04	5	23632	102575	79618176
Colony stimulating factor therapy	16.08	16.04	6	23631	518	79720233

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	M02AA31	MUSCULO-SKELETAL SYSTEM TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN Antiinflammatory preparations, non-steroids for topical use
MeSH PA	D000700	Analgesics
MeSH PA	D018712	Analgesics, Non-Narcotic
MeSH PA	D000893	Anti-Inflammatory Agents
MeSH PA	D000894	Anti-Inflammatory Agents, Non-Steroidal
MeSH PA	D018501	Antirheumatic Agents
MeSH PA	D018373	Peripheral Nervous System Agents
MeSH PA	D018689	Sensory System Agents
CHEBI has role	CHEBI:35475	non-steroidal anti-inflammatory agent
CHEBI has role	CHEBI:35493	anti-pyretic
CHEBI has role	CHEBI:35544	cyclooxygenase inhibitors
CHEBI has role	CHEBI:50266	Prodrugs

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Rheumatoid arthritis	indication	69896004	DOID:7148

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	4.37	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Prostaglandin G/H synthase 2	Enzyme	P35354	PGH2_HUMAN	INHIBITOR	IC50	5		CHEMBL	KEGG DRUG
Prostaglandin G/H synthase 1	Enzyme	P23219	PGH1_HUMAN	INHIBITOR	IC50	5.19		CHEMBL	KEGG DRUG

External reference:

ID	Source
D08149	KEGG_DRUG
C0065199	UMLSCUI
CHEBI:31786	CHEBI
CHEMBL19299	ChEMBL_ID
DB09212	DRUGBANK_ID
C040656	MESH_SUPPLEMENTAL_RECORD_UI
3965	PUBCHEM_CID
5410	INN_ID
80382-23-6	SECONDARY_CAS_RN
3583H0GZAP	UNII
28908	RXNORM
008162	NDDF
18991000122102	SNOMEDCT_US
CHEMBL66552	ChEMBL_ID

Pharmaceutical products:

None