aminoacridine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| acridine derivatives | 160 | 90-45-9 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A highly fluorescent anti-infective dye used clinically as a topical antiseptic and experimentally as a mutagen, due to its interaction with DNA. It is also used as an intracellular pH indicator.
|
Drug dosage:
None
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | D08AA02 | DERMATOLOGICALS ANTISEPTICS AND DISINFECTANTS ANTISEPTICS AND DISINFECTANTS Acridine derivatives |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000891 | Anti-Infective Agents, Local |
| MeSH PA | D004396 | Coloring Agents |
| MeSH PA | D005456 | Fluorescent Dyes |
| MeSH PA | D007202 | Indicators and Reagents |
| MeSH PA | D049408 | Luminescent Agents |
| MeSH PA | D009153 | Mutagens |
| MeSH PA | D009676 | Noxae |
| CHEBI has role | CHEBI:25435 | mutagens |
| CHEBI has role | CHEBI:35441 | antiinfective agents |
| CHEBI has role | CHEBI:48218 | antiseptics |
| CHEBI has role | CHEBI:50407 | acid-base indicator |
| CHEBI has role | CHEBI:51121 | fluorescent dyes |
| CHEBI has role | CHEBI:64345 | matrix-assisted laser desorption/ionization matrix materials |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Anemia due to enzyme deficiency | contraindication | 111577008 | |
| Deficiency of glucose-6-phosphate dehydrogenase | contraindication | 124134002 | DOID:2862 |
| Disease of blood AND/OR blood-forming organ | contraindication | 191124002 | DOID:74 |
| Disease of liver | contraindication | 235856003 | DOID:409 |
| Porphyria | contraindication | 418470004 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 9.54 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Ribosyldihydronicotinamide dehydrogenase [quinone] | Enzyme | IC50 | 6.36 | CHEMBL | |||||
| Amine oxidase [flavin-containing] A | Enzyme | IC50 | 4.58 | CHEMBL | |||||
| Trypanothione reductase | Enzyme | Ki | 4.42 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4018614 | VUID |
| N0000179393 | NUI |
| D02905 | KEGG_DRUG |
| 134-50-9 | SECONDARY_CAS_RN |
| 645 | RXNORM |
| C0002503 | UMLSCUI |
| CHEBI:51803 | CHEBI |
| AA | PDB_CHEM_ID |
| CHEMBL43184 | ChEMBL_ID |
| 7019 | PUBCHEM_CID |
| DB11561 | DRUGBANK_ID |
| CHEMBL1330022 | ChEMBL_ID |
| NOCODE | MMSL |
| 391756001 | SNOMEDCT_US |
| 6602005 | SNOMEDCT_US |
| 714291009 | SNOMEDCT_US |
| D000585 | MESH_DESCRIPTOR_UI |
| 1476 | INN_ID |
| 4018614 | VANDF |
| 4019604 | VANDF |
| OR5RM3Q5QL | UNII |
| 002960 | NDDF |
| 004875 | NDDF |
Pharmaceutical products:
None