lonidamine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 1598 | 50264-69-2 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
None
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | L01XX07 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS OTHER ANTINEOPLASTIC AGENTS Other antineoplastic agents |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000970 | Antineoplastic Agents |
| MeSH PA | D000977 | Antiparasitic Agents |
| MeSH PA | D000981 | Antiprotozoal Agents |
| MeSH PA | D000988 | Antispermatogenic Agents |
| MeSH PA | D003270 | Contraceptive Agents |
| MeSH PA | D003272 | Contraceptive Agents, Male |
| MeSH PA | D009676 | Noxae |
| MeSH PA | D011838 | Radiation-Sensitizing Agents |
| MeSH PA | D012102 | Reproductive Control Agents |
| MeSH PA | D014344 | Trypanocidal Agents |
| CHEBI has role | CHEBI:35610 | antineoplastic agents |
| CHEBI has role | CHEBI:78366 | hexokinase type IV glucokinase inhibitor |
| CHEBI has role | CHEBI:145047 | antispermatogenic agents |
| CHEBI has role | CHEBI:176497 | geroprotectors |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Malignant tumor of lung | indication | 363358000 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 3.85 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Mitochondrial pyruvate carrier 2 | Transporter | INHIBITOR | IC50 | 5.34 | IUPHAR |
External reference:
| ID | Source |
|---|---|
| D07257 | KEGG_DRUG |
| C0065175 | UMLSCUI |
| CHEBI:50138 | CHEBI |
| CHEMBL1257030 | ChEMBL_ID |
| DB06266 | DRUGBANK_ID |
| C016371 | MESH_SUPPLEMENTAL_RECORD_UI |
| 39562 | PUBCHEM_CID |
| 12601 | IUPHAR_LIGAND_ID |
| 4324 | INN_ID |
| U78804BIDR | UNII |
Pharmaceutical products:
None