lomerizine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
diphenylmethyl piperazine derivatives 1595 101477-55-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • lomerizine dihydrochloride
  • lomerizine
  • lomerizine hydrochloride
  • lomerizine HCl
used to treat migraines
  • Molecular weight: 468.55
  • Formula: C27H30F2N2O3
  • CLOGP: 5.21
  • LIPINSKI: 1
  • HAC: 5
  • HDO: 0
  • TPSA: 34.17
  • ALOGS: -4.84
  • ROTB: 8

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D002121 Calcium Channel Blockers
MeSH PA D000077264 Calcium-Regulating Hormones and Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D049990 Membrane Transport Modulators

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.03 Basic
pKa2 3.03 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Voltage-dependent N-type calcium channel subunit alpha-1B Ion channel IC50 5.61 CHEMBL

External reference:

IDSource
D02633 KEGG_DRUG
C0630704 UMLSCUI
CHEBI:94682 CHEBI
CHEMBL29188 ChEMBL_ID
DB14065 DRUGBANK_ID
C052424 MESH_SUPPLEMENTAL_RECORD_UI
7004 INN_ID
101477-54-7 SECONDARY_CAS_RN
DEE37CY4VO UNII
3949 PUBCHEM_CID

Pharmaceutical products:

None