lidoflazine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	1580	3416-26-0

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

lidoflazine
corflazine
lidoflazin
lidoflazinum
ordiflazine

Coronary vasodilator with some antiarrhythmic action.

Molecular weight: 491.63
Formula: C30H35F2N3O
CLOGP: 4.79
LIPINSKI: 0
HAC: 4
HDO: 1
TPSA: 35.58
ALOGS: -5.74
ROTB: 9

Drug dosage:

Dose	Unit	Route
0.18	g	O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	C08EX01	CARDIOVASCULAR SYSTEM CALCIUM CHANNEL BLOCKERS NON-SELECTIVE CALCIUM CHANNEL BLOCKERS Other non-selective calcium channel blockers
MeSH PA	D002121	Calcium Channel Blockers
MeSH PA	D000077264	Calcium-Regulating Hormones and Agents
MeSH PA	D002317	Cardiovascular Agents
MeSH PA	D049990	Membrane Transport Modulators
MeSH PA	D014665	Vasodilator Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	13.4	acidic
pKa2	7.42	Basic
pKa3	3.42	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Potassium voltage-gated channel subfamily H member 2	Ion channel	Q12809	KCNH2_HUMAN		IC50	7.80		CHEMBL
Equilibrative nucleoside transporter 1	Transporter	Q99808	S29A1_HUMAN		Ki	6.55		CHEMBL
Sodium channel alpha subunits; brain (Types I, II, III)	Ion channel		SCN1A_RAT SCN2A_RAT SCN3A_RAT		Ki	7.11		CHEMBL

External reference:

ID	Source
N0000167118	NUI
D04733	KEGG_DRUG
C0023665	UMLSCUI
CHEBI:93095	CHEBI
CHEMBL92870	ChEMBL_ID
D008013	MESH_DESCRIPTOR_UI
DB13766	DRUGBANK_ID
1925	INN_ID
J4ZHN3HBTE	UNII
3926	PUBCHEM_CID
6390	RXNORM
319206000	SNOMEDCT_US
418865004	SNOMEDCT_US

Pharmaceutical products:

None