levomethadyl acetate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 1571 | 1477-40-3 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 11.32 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| Vd (Volume of distribution) | 8.30 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 5.40 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.20 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 18 hours | Lombardo F, Berellini G, Obach RS |
| S (Water solubility) | 15 mg/mL | Bocci G, Oprea TI, Benet LZ |
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Bocci G, Oprea TI, Benet LZ |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Jan. 7, 1997 | EMA | ||
| July 9, 1993 | FDA | ROXANE |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | N07BC03 | NERVOUS SYSTEM OTHER NERVOUS SYSTEM DRUGS DRUGS USED IN ADDICTIVE DISORDERS Drugs used in opioid dependence |
| MeSH PA | D000700 | Analgesics |
| MeSH PA | D000701 | Analgesics, Opioid |
| MeSH PA | D002491 | Central Nervous System Agents |
| MeSH PA | D002492 | Central Nervous System Depressants |
| MeSH PA | D009294 | Narcotics |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
| MeSH PA | D018689 | Sensory System Agents |
| CHEBI has role | CHEBI:35482 | narcotic analgesic |
| CHEBI has role | CHEBI:50137 | mu-opioid receptor antagonists |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Opioid dependence | indication | 75544000 | DOID:2559 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 8.83 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Mu-type opioid receptor | GPCR | AGONIST | WOMBAT-PK | CHEMBL | |||||
| Potassium voltage-gated channel subfamily H member 2 | Ion channel | IC50 | 5.66 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4020836 | VUID |
| N0000179426 | NUI |
| D00840 | KEGG_DRUG |
| 43033-72-3 | SECONDARY_CAS_RN |
| 14019-10-4 | SECONDARY_CAS_RN |
| 4020836 | VANDF |
| 4020848 | VANDF |
| CHEBI:6441 | CHEBI |
| CHEMBL1514 | ChEMBL_ID |
| CHEMBL1200817 | ChEMBL_ID |
| 7212 | IUPHAR_LIGAND_ID |
| 3175 | INN_ID |
| DB01227 | DRUGBANK_ID |
| R3B637Y991 | UNII |
| 218943 | RXNORM |
| 3114 | MMSL |
| 4973 | MMSL |
| d03187 | MMSL |
| 004753 | NDDF |
| 004754 | NDDF |
| 007409 | NDDF |
| 108375002 | SNOMEDCT_US |
| 108378000 | SNOMEDCT_US |
| 409482006 | SNOMEDCT_US |
| C3536876 | UMLSCUI |
| D008692 | MESH_DESCRIPTOR_UI |
| 15130 | PUBCHEM_CID |
Pharmaceutical products:
None