levetiracetam ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
amide type nootrope agents, piracetam derivatives 1563 102767-28-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • keppra
  • levetiracetam
  • matever
  • (-)-Levetiracetam
  • levroxa
  • UCB-6474
  • UCB 6474
The precise mechanism(s) by which levetiracetam exerts its antiepileptic effect is unknown. The antiepileptic activity of levetiracetam was assessed in a number of animal models of epileptic seizures. Levetiracetam did not inhibit single seizures induced by maximal stimulation with electrical current or different chemoconvulsants and showed only minimal activity in submaximal stimulation and in threshold tests. Protection was observed, however, against secondarily generalized activity from focal seizures induced by pilocarpine and kainic acid, two chemoconvulsants that induce seizures that mimic some features of human complex partial seizures with secondary generalization. Levetiracetam also displayed inhibitory properties in the kindling model in rats, another model of human complex partial seizures, both during kindling development and in the fully kindled state. In vitro and in vivo recordings of epileptiform activity from the hippocampus have shown that levetiracetam inhibits burst firing without affecting normal neuronal excitability, suggesting that levetiracetam may selectively prevent hypersynchronization of epileptiform burst firing and propagation of seizure activity. Levetiracetam at concentrations of up to 10 uM did not demonstrate binding affinity for a variety of known receptors, such as those associated with benzodiazepines, GABA (gamma-aminobutyric acid), glycine, NMDA (N-methyl-D-aspartate), re-uptake sites, and second messenger systems. Furthermore, in vitro studies have failed to find an effect of levetiracetam on neuronal voltage-gated sodium or T-type calcium currents and levetiracetam does not appear to directly facilitate GABAergic neurotransmission. However, in vitro studies have demonstrated that levetiracetam opposes the activity of negative modulators of GABA- and glycine-gated currents and partially inhibits N-type calcium currents in neuronal cells. A saturable and stereoselective neuronal binding site in rat brain tissue has been described for levetiracetam. Experimental data indicate that this binding site is the synaptic vesicle protein SV2A, thought to be involved in the regulation of vesicle exocytosis. Although the molecular significance of levetiracetam binding to synaptic vesicle protein SV2A is not understood, levetiracetam and related analogs showed a rank order of affinity for SV2A which correlated with the potency of their antiseizure activity in audiogenic seizure-prone mice. These findings suggest that the interaction of levetiracetam with the SV2A protein may contribute to the antiepileptic mechanism of action of the drug.
  • Molecular weight: 170.21
  • Formula: C8H14N2O2
  • CLOGP: -0.34
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 63.40
  • ALOGS: 0.24
  • ROTB: 3

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
1.50 g O
1.50 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 1040 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 66 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 251.79 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 99 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.60 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.90 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.90 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 8.23 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Sept. 29, 2000 EMA
Nov. 30, 1999 FDA UCB INC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Seizure 5285.57 10.73 3159 99157 114715 50388093
Abortion spontaneous 2326.55 10.73 1293 101023 40479 50462329
Status epilepticus 1992.39 10.73 816 101500 12590 50490218
Pregnancy 1487.62 10.73 857 101459 28720 50474088
Generalised tonic-clonic seizure 1314.09 10.73 759 101557 25551 50477257
Epilepsy 1071.05 10.73 620 101696 20947 50481861
Maternal exposure during pregnancy 992.11 10.73 1407 100909 158371 50344437
Multiple-drug resistance 817.28 10.73 292 102024 3022 50499786
Partial seizures 624.57 10.73 267 102049 4598 50498210
Exposure during pregnancy 595.40 10.73 957 101359 120058 50382750
Aggression 551.78 10.73 406 101910 20710 50482098
Product substitution issue 508.01 10.73 330 101986 13727 50489081
Stillbirth 475.66 10.73 235 102081 5717 50497091
Psychogenic seizure 465.11 10.73 159 102157 1426 50501382
Focal dyscognitive seizures 445.82 10.73 178 102138 2554 50500254
Petit mal epilepsy 423.80 10.73 181 102135 3108 50499700
Arthralgia 378.14 10.73 209 102107 438493 50064315
Abortion induced 349.03 10.73 224 102092 9120 50493688
Rheumatoid arthritis 332.93 10.73 19 102297 202531 50300277
Foetal exposure during pregnancy 329.48 10.73 338 101978 27021 50475787
Pain 324.85 10.73 418 101898 578485 49924323
Drug reaction with eosinophilia and systemic symptoms 302.87 10.73 329 101987 28095 50474713
Joint swelling 287.81 10.73 71 102245 245215 50257593
Irritability 282.11 10.73 317 101999 28109 50474699
Paradoxical drug reaction 279.58 10.73 140 102176 3507 50499301
Anticonvulsant drug level decreased 273.01 10.73 99 102217 1072 50501736
Somnolence 266.22 10.73 802 101514 154183 50348625
Abdominal discomfort 256.72 10.73 75 102241 231566 50271242
Contraindicated product administered 247.72 10.73 13 102303 148945 50353863
Arthropathy 244.30 10.73 20 102296 157886 50344922
Psychotic disorder 236.79 10.73 255 102061 21557 50481251
Abnormal behaviour 226.11 10.73 237 102079 19421 50483387
Synovitis 222.34 10.73 6 102310 123859 50378949
Myoclonic epilepsy 221.98 10.73 81 102235 894 50501914
Drug interaction 218.57 10.73 890 101426 198731 50304077
Swelling 208.39 10.73 73 102243 200799 50302009
Dyspnoea 206.75 10.73 506 101810 547102 49955706
Infusion related reaction 202.86 10.73 47 102269 169510 50333298
Cytokine release syndrome 198.84 10.73 154 102162 8480 50494328
Thrombocytopenia 186.46 10.73 625 101691 127048 50375760
Drug withdrawal convulsions 186.09 10.73 78 102238 1275 50501533
Behaviour disorder 184.31 10.73 92 102224 2288 50500520
Glossodynia 183.35 10.73 13 102303 115556 50387252
Overdose 181.47 10.73 527 101789 99200 50403608
Agitation 178.29 10.73 357 101959 53027 50449781
Premature delivery 174.45 10.73 227 102089 23436 50479372
Peripheral swelling 172.80 10.73 101 102215 205835 50296973
Sudden unexplained death in epilepsy 172.38 10.73 50 102266 243 50502565
Sinusitis 171.76 10.73 65 102251 170493 50332315
Encephalopathy 171.42 10.73 271 102045 33440 50469368
Anticonvulsant drug level increased 167.91 10.73 73 102243 1311 50501497
Drug ineffective for unapproved indication 162.91 10.73 208 102108 21073 50481735
Hyperammonaemic encephalopathy 162.90 10.73 80 102236 1919 50500889
Myoclonus 154.99 10.73 168 102148 14302 50488506
Ataxia 151.07 10.73 162 102154 13624 50489184
Aura 146.75 10.73 60 102256 918 50501890
Alopecia 146.28 10.73 168 102148 244879 50257929
Caesarean section 144.30 10.73 168 102148 15471 50487337
Aphasia 143.40 10.73 228 102088 28266 50474542
Pain in extremity 142.36 10.73 207 102109 272658 50230150
Diarrhoea 139.30 10.73 665 101651 587811 49914997
Infantile spasms 137.35 10.73 39 102277 173 50502635
Drug resistance 136.61 10.73 180 102136 18809 50483999
Discomfort 135.78 10.73 27 102289 108353 50394455
Pericarditis 133.55 10.73 6 102310 78683 50424125
Low birth weight baby 131.31 10.73 103 102213 5778 50497030
Maternal drugs affecting foetus 128.92 10.73 96 102220 4981 50497827
Electroencephalogram abnormal 128.48 10.73 83 102233 3416 50499392
Drug intolerance 125.63 10.73 155 102161 218949 50283859
Therapeutic product effect decreased 125.47 10.73 59 102257 135991 50366817
Stevens-Johnson syndrome 124.85 10.73 185 102131 21567 50481241
Systemic lupus erythematosus 123.63 10.73 65 102251 140557 50362251
Drug hypersensitivity 122.67 10.73 199 102117 250811 50251997
Hyperammonaemia 121.47 10.73 90 102226 4634 50498174
Nasopharyngitis 120.90 10.73 127 102189 192800 50310008
Disturbance in attention 119.35 10.73 221 102095 30965 50471843
Small for dates baby 118.60 10.73 79 102237 3426 50499382
Maternal exposure during breast feeding 116.56 10.73 76 102240 3178 50499630
Breast feeding 113.66 10.73 48 102268 800 50502008
Seizure cluster 113.59 10.73 34 102282 188 50502620
Lower respiratory tract infection 112.58 10.73 27 102289 95174 50407634
Acute generalised exanthematous pustulosis 110.42 10.73 112 102204 8826 50493982
Tonic convulsion 109.30 10.73 51 102265 1088 50501720
Nausea 109.09 10.73 909 101407 704489 49798319
Hypersensitivity 108.49 10.73 167 102149 214994 50287814
Simple partial seizures 108.24 10.73 41 102275 506 50502302
Drug ineffective 107.12 10.73 2281 100035 817052 49685756
Rhabdomyolysis 106.00 10.73 240 102076 38787 50464021
Partial seizures with secondary generalisation 104.69 10.73 35 102281 291 50502517
Off label use 104.58 10.73 1438 100878 472988 50029820
Cognitive disorder 104.28 10.73 257 102059 43866 50458942
Exposure via breast milk 103.82 10.73 55 102261 1553 50501255
Atonic seizures 103.77 10.73 41 102275 571 50502237
Substance-induced psychotic disorder 103.02 10.73 55 102261 1578 50501230
Maternal exposure before pregnancy 101.80 10.73 87 102229 5510 50497298
Wound 97.34 10.73 46 102270 105748 50397060
Impaired healing 97.18 10.73 13 102303 69773 50433035
Injection site pain 96.57 10.73 52 102264 110972 50391836
Musculoskeletal stiffness 95.56 10.73 72 102244 128409 50374399
Drug level increased 92.60 10.73 151 102165 19117 50483691
Aplastic anaemia 90.59 10.73 94 102222 7609 50495199
Anticonvulsant drug level above therapeutic 89.20 10.73 35 102281 478 50502330
Hallucination, visual 88.02 10.73 136 102180 16446 50486362
Fatigue 86.75 10.73 965 101351 706636 49796172
Glioblastoma multiforme 86.52 10.73 38 102278 700 50502108
Osteoarthritis 86.10 10.73 17 102299 68589 50434219
Anger 85.51 10.73 110 102206 11223 50491585
Hallucination, auditory 83.90 10.73 106 102210 10622 50492186
Neurotoxicity 82.63 10.73 124 102192 14616 50488192
Immune effector cell-associated neurotoxicity syndrome 81.88 10.73 42 102274 1108 50501700
Drug level decreased 80.95 10.73 82 102234 6451 50496357
Respiratory disorder neonatal 80.70 10.73 39 102277 902 50501906
Back pain 80.55 10.73 206 102110 219824 50282984
Hemiparesis 80.40 10.73 145 102171 19903 50482905
Persecutory delusion 78.84 10.73 53 102263 2334 50500474
Weight gain poor 78.77 10.73 36 102280 731 50502077
Infection 78.13 10.73 144 102172 172810 50329998
Brain oedema 77.98 10.73 110 102206 12260 50490548
Arthritis 77.81 10.73 39 102277 86682 50416126
Pruritus 77.46 10.73 303 102013 283265 50219543
Anticonvulsant drug level below therapeutic 77.28 10.73 33 102283 566 50502242
No adverse event 76.61 10.73 193 102123 33385 50469423
Malaise 76.29 10.73 384 101932 335148 50167660
Propofol infusion syndrome 75.68 10.73 35 102281 731 50502077
Suicidal ideation 75.37 10.73 265 102051 55120 50447688
Pancytopenia 75.20 10.73 353 101963 83677 50419131
Asthma 74.58 10.73 44 102272 89293 50413515
Change in seizure presentation 74.44 10.73 26 102290 250 50502558
Cough 74.37 10.73 245 102071 241019 50261789
Leukopenia 72.83 10.73 300 102016 67228 50435580
Encephalitis autoimmune 72.76 10.73 40 102276 1218 50501590
Mood altered 72.38 10.73 108 102208 12665 50490143
Central nervous system lesion 71.43 10.73 92 102224 9397 50493411
Brain neoplasm 71.39 10.73 60 102256 3713 50499095
Agranulocytosis 68.79 10.73 141 102175 21280 50481528
Irritable bowel syndrome 68.34 10.73 11 102305 51430 50451378
Selective eating disorder 66.14 10.73 43 102273 1789 50501019
Foetal growth restriction 65.88 10.73 74 102242 6553 50496255
Premature baby 65.26 10.73 126 102190 18211 50484597
Paranoia 65.20 10.73 92 102224 10256 50492552
Psychomotor hyperactivity 65.09 10.73 87 102229 9214 50493594
Psoriatic arthropathy 64.91 10.73 9 102307 47023 50455785
Hypotonia 64.61 10.73 81 102235 8053 50494755
Toxicity to various agents 64.02 10.73 684 101632 211815 50290993
Abdominal pain upper 63.96 10.73 142 102174 159167 50343641
Congenital cyst 63.21 10.73 14 102302 14 50502794
Speech disorder 62.79 10.73 186 102130 35362 50467446
Injection site erythema 62.41 10.73 37 102279 74899 50427909
Affective disorder 62.32 10.73 64 102252 5117 50497691
Diplopia 62.11 10.73 127 102189 19133 50483675
Nystagmus 62.07 10.73 66 102250 5495 50497313
Hypertension 61.33 10.73 220 102096 210983 50291825
Toxic epidermal necrolysis 60.26 10.73 132 102184 20860 50481948
Coma 60 10.73 251 102065 56628 50446180
Altered state of consciousness 59.77 10.73 135 102181 21775 50481033
Cardiac failure congestive 59.31 10.73 50 102266 84332 50418476
Chest pain 59.16 10.73 173 102143 176709 50326099
Blood pressure increased 59.09 10.73 112 102204 133020 50369788
Psoriasis 58.99 10.73 33 102283 68967 50433841
Bronchitis 58.25 10.73 75 102241 104084 50398724
Posterior reversible encephalopathy syndrome 57.37 10.73 106 102210 14822 50487986
Oedema peripheral 56.92 10.73 149 102167 157812 50344996
Knee arthroplasty 56.91 10.73 4 102312 35842 50466966
Delusion 56.54 10.73 87 102229 10482 50492326
Hepatocellular injury 55.94 10.73 146 102170 25801 50477007
Gastrointestinal disorder 54.93 10.73 66 102250 94390 50408418
Epileptic aura 54.88 10.73 15 102301 56 50502752
Suicidal behaviour 54.54 10.73 42 102274 2292 50500516
Pre-eclampsia 54.40 10.73 74 102242 7970 50494838
Mitochondrial DNA mutation 54.07 10.73 20 102296 230 50502578
Suppressed lactation 53.10 10.73 23 102293 409 50502399
Intra-abdominal pressure increased 52.87 10.73 19 102297 200 50502608
Disorientation 52.84 10.73 175 102141 35309 50467499
Deja vu 52.60 10.73 14 102302 46 50502762
Hepatic enzyme increased 52.27 10.73 126 102190 137254 50365554
Product administration error 52.21 10.73 120 102196 19579 50483229
Cerebral haemorrhage 52.08 10.73 146 102170 26906 50475902
Acute psychosis 51.99 10.73 40 102276 2180 50500628
Glioblastoma 51.93 10.73 27 102289 733 50502075
Learning disorder 51.16 10.73 25 102291 593 50502215
Sopor 50.39 10.73 119 102197 19760 50483048
Abdominal pain 49.91 10.73 277 102039 235951 50266857
Pneumatosis 49.90 10.73 22 102294 409 50502399
Blood cholesterol increased 49.26 10.73 25 102291 55190 50447618
Fibromyalgia 48.94 10.73 15 102301 44963 50457845
Mental status changes 48.86 10.73 173 102143 36099 50466709
Myocardial infarction 48.86 10.73 65 102251 88962 50413846
Hyponatraemia 48.59 10.73 347 101969 95792 50407016
Chest discomfort 48.58 10.73 70 102246 92652 50410156
Dysarthria 48.34 10.73 176 102140 37227 50465581
Cerebellar ataxia 48.27 10.73 27 102289 851 50501957
Herpes zoster 47.27 10.73 44 102272 70742 50432066
Osteoporosis 47 10.73 16 102300 44863 50457945
Porphyria acute 46.90 10.73 22 102294 475 50502333
Musculoskeletal pain 46.87 10.73 46 102270 72131 50430677
Idiopathic generalised epilepsy 46.85 10.73 9 102307 0 50502808
Affect lability 46.64 10.73 73 102243 8925 50493883
Hip arthroplasty 46.61 10.73 4 102312 30425 50472383
Bradycardia neonatal 46.47 10.73 26 102290 820 50501988
Cataract 45.96 10.73 19 102297 47281 50455527
Confusional state 45.49 10.73 575 101741 185353 50317455
Bradyphrenia 45.30 10.73 59 102257 6093 50496715
Teratogenicity 45.26 10.73 14 102302 88 50502720
Cholestasis 44.95 10.73 133 102183 25268 50477540
Injection site pruritus 44.83 10.73 13 102303 40398 50462410
Mutism 44.03 10.73 30 102286 1351 50501457
Hallucination 43.93 10.73 199 102117 46458 50456350
Excessive eye blinking 43.77 10.73 26 102290 920 50501888
Accidental poisoning 42.90 10.73 22 102294 580 50502228
Injection site reaction 42.66 10.73 24 102292 50008 50452800
Red blood cell sedimentation rate increased 42.11 10.73 5 102311 29411 50473397
Hypothermia 42.06 10.73 82 102234 11934 50490874
Haemophagocytic lymphohistiocytosis 41.94 10.73 68 102248 8565 50494243
Malignant catatonia 41.40 10.73 14 102302 121 50502687
Depressed mood 41.38 10.73 157 102159 33866 50468942
Therapeutic response unexpected 41.13 10.73 96 102220 15819 50486989
Flushing 40.93 10.73 45 102271 66970 50435838
Wheezing 40.92 10.73 39 102277 62008 50440800
Bradycardia 40.73 10.73 246 102070 64180 50438628
Dysmorphism 40.05 10.73 34 102282 2133 50500675
Intellectual disability 39.84 10.73 23 102293 771 50502037
Memory impairment 39.84 10.73 286 102030 79074 50423734
Granuloma annulare 39.71 10.73 20 102296 507 50502301
Mobility decreased 39.33 10.73 63 102253 79885 50422923
Stomatitis 39.30 10.73 92 102224 101252 50401556
Hepatitis 38.97 10.73 146 102170 31307 50471501
Hypomagnesaemia 38.85 10.73 119 102197 23037 50479771
Injection site swelling 38.65 10.73 18 102298 41755 50461053
Inflammation 38.44 10.73 35 102281 56877 50445931
Suicide attempt 38.27 10.73 206 102110 51526 50451282
Developmental glaucoma 38.17 10.73 11 102305 52 50502756
Thinking abnormal 38.11 10.73 69 102247 9498 50493310
Rash 37.40 10.73 641 101675 436830 50065978
JC polyomavirus test 37.31 10.73 10 102306 34 50502774
Osteonecrosis of jaw 36.94 10.73 10 102306 32516 50470292
Brain operation 36.94 10.73 19 102297 504 50502304
Organic brain syndrome 36.51 10.73 14 102302 179 50502629
Nasal congestion 36.27 10.73 30 102286 51090 50451718
Intentional self-injury 36.22 10.73 116 102200 22996 50479812
Exomphalos 35.94 10.73 19 102297 534 50502274
Eosinophilic cystitis 35.77 10.73 9 102307 22 50502786
Pleocytosis 35.72 10.73 19 102297 541 50502267
Staring 35.49 10.73 27 102289 1447 50501361
Ill-defined disorder 35.29 10.73 35 102281 54619 50448189
Personality change 35.28 10.73 50 102266 5595 50497213
Acute myocardial infarction 35.19 10.73 8 102308 29265 50473543
Retrograde amnesia 35.14 10.73 17 102299 394 50502414
Neuropsychiatric symptoms 35.12 10.73 19 102297 560 50502248
Treatment failure 35.05 10.73 151 102165 137486 50365322
Angiofibroma 34.96 10.73 12 102304 109 50502699
Apathy 34.71 10.73 58 102258 7490 50495318
Toxic encephalopathy 34.69 10.73 49 102267 5466 50497342
Obsessive-compulsive disorder 34.41 10.73 38 102278 3302 50499506
Necrotising colitis 34.34 10.73 18 102298 497 50502311
Dyspnoea exertional 34.02 10.73 32 102284 51201 50451607
Delirium 33.82 10.73 160 102156 38032 50464776
Tongue biting 33.43 10.73 25 102291 1305 50501503
Night sweats 33.41 10.73 13 102303 33561 50469247
Fluid retention 33.21 10.73 32 102284 50617 50452191
Skin ulcer 33.02 10.73 15 102301 35303 50467505
Metabolic encephalopathy 32.96 10.73 46 102270 5075 50497733
Febrile convulsion 32.95 10.73 16 102300 374 50502434
Mania 32.88 10.73 70 102246 10846 50491962
Mood swings 32.59 10.73 88 102228 15866 50486942
Toxic skin eruption 32.57 10.73 71 102245 11180 50491628
Myalgia 32.51 10.73 135 102181 124184 50378624
Anaemia 32.43 10.73 340 101976 252116 50250692
Muscle twitching 32.41 10.73 86 102230 15345 50487463
Eosinophilia 32.37 10.73 97 102219 18555 50484253
Coronary artery disease 32.18 10.73 10 102306 29716 50473092
Pemphigoid 32.12 10.73 49 102267 5858 50496950
Acidosis hyperchloraemic 32.02 10.73 15 102301 323 50502485
Necrosis ischaemic 31.94 10.73 20 102296 779 50502029
Ammonia increased 31.74 10.73 41 102275 4200 50498608
Meningioma 31.72 10.73 37 102279 3412 50499396
Autism spectrum disorder 31.69 10.73 19 102297 684 50502124
Postictal psychosis 31.67 10.73 8 102308 20 50502788
Respiratory acidosis 31.37 10.73 49 102267 5979 50496829
Gastrointestinal haemorrhage 31.37 10.73 63 102253 73258 50429550
Intentional product use issue 31.30 10.73 68 102248 76850 50425958
Grey matter heterotopia 31.24 10.73 6 102310 0 50502808
Postictal state 31.15 10.73 21 102295 929 50501879
Screaming 30.88 10.73 34 102282 2944 50499864
Blood creatine phosphokinase increased 30.70 10.73 120 102196 26247 50476561
Cross sensitivity reaction 30.60 10.73 28 102288 1941 50500867
Acute hepatic failure 30.56 10.73 85 102231 15592 50487216
Palpitations 30.44 10.73 94 102222 94412 50408396
Twin pregnancy 30.41 10.73 22 102294 1091 50501717
Necrobiosis lipoidica diabeticorum 30.36 10.73 8 102308 25 50502783
Depressed level of consciousness 30.10 10.73 194 102122 51759 50451049
Drug clearance increased 30.03 10.73 10 102306 82 50502726
Poverty of thought content 29.85 10.73 7 102309 11 50502797
Intracranial tumour haemorrhage 29.78 10.73 11 102305 126 50502682
Dyspepsia 29.75 10.73 66 102250 74031 50428777
Treatment noncompliance 29.44 10.73 130 102186 30020 50472788
Oropharyngeal oedema 29.42 10.73 13 102303 243 50502565
Dyskinesia 29.41 10.73 123 102193 27738 50475070
Meningitis aseptic 29.30 10.73 39 102277 4113 50498695
Cellulitis 29.30 10.73 62 102254 70736 50432072
Retinogram abnormal 29.17 10.73 11 102305 134 50502674
Brief psychotic disorder, with postpartum onset 29.04 10.73 8 102308 31 50502777
Ankyloglossia congenital 28.86 10.73 12 102304 192 50502616
Blood pressure systolic increased 28.82 10.73 18 102298 35431 50467377
Pulmonary fibrosis 28.74 10.73 7 102309 24430 50478378
Hydrops foetalis 28.69 10.73 14 102302 331 50502477
Electrocardiogram QRS complex prolonged 28.60 10.73 44 102272 5300 50497508
Pulmonary hypertension 28.53 10.73 16 102300 33401 50469407
Osteochondrosis 28.48 10.73 21 102295 1073 50501735
Productive cough 28.37 10.73 39 102277 52655 50450153
Diverticulitis 28.17 10.73 16 102300 33166 50469642
Joint stiffness 28.13 10.73 13 102303 30295 50472513
Macroglossia 28.13 10.73 17 102299 621 50502187
Product packaging confusion 28.12 10.73 11 102305 149 50502659
Restlessness 28.04 10.73 113 102203 25060 50477748
Dry eye 27.93 10.73 15 102301 32080 50470728
Hypotonia neonatal 27.91 10.73 20 102296 977 50501831
Feeling hot 27.82 10.73 23 102293 39179 50463629
Gene mutation 27.81 10.73 22 102294 1249 50501559
Tremor 27.49 10.73 354 101962 114549 50388259
Limbic encephalitis 27.32 10.73 12 102304 221 50502587
Loss of personal independence in daily activities 26.82 10.73 64 102252 69986 50432822
White matter lesion 26.80 10.73 24 102292 1618 50501190
Hippocampal sclerosis 26.80 10.73 9 102307 76 50502732
Cytomegalovirus hepatitis 26.77 10.73 13 102303 304 50502504
Spina bifida 26.74 10.73 17 102299 680 50502128
Intentional overdose 26.74 10.73 217 102099 62287 50440521
Blood pressure fluctuation 26.71 10.73 20 102296 35803 50467005
Crystal nephropathy 26.69 10.73 18 102298 797 50502011
Weight increased 26.28 10.73 271 102045 201620 50301188
Gingival hypertrophy 26.14 10.73 22 102294 1364 50501444
Apraxia 26.04 10.73 23 102293 1522 50501286
Amniotic band syndrome 26.03 10.73 5 102311 0 50502808
Metastases to central nervous system 25.89 10.73 65 102251 11217 50491591
Depression 25.83 10.73 474 101842 164949 50337859
Ultrasound ovary abnormal 25.72 10.73 9 102307 87 50502721
Eosinophilic pneumonia 25.62 10.73 25 102291 1879 50500929
Blood gases abnormal 25.56 10.73 16 102300 623 50502185
Constipation 25.53 10.73 246 102070 185462 50317346
Muscle spasms 25.52 10.73 149 102167 125404 50377404
Sciatica 25.39 10.73 6 102310 21376 50481432
Rash maculo-papular 25.35 10.73 114 102202 26527 50476281
Gastrooesophageal reflux disease 25.34 10.73 75 102241 76353 50426455
Abortion 25.12 10.73 26 102290 2098 50500710
Basal cell carcinoma 25.03 10.73 8 102308 23348 50479460
CSF measles antibody positive 25.00 10.73 8 102308 57 50502751
Product name confusion 24.76 10.73 8 102308 59 50502749
Angiomyolipoma 24.69 10.73 11 102305 210 50502598
Urticaria 24.64 10.73 157 102159 129404 50373404
Condition aggravated 24.62 10.73 780 101536 296278 50206530
Oropharyngeal pain 24.62 10.73 78 102238 77723 50425085
Hypertonia 24.55 10.73 35 102281 3938 50498870
Hot flush 24.48 10.73 32 102284 44137 50458671
Device expulsion 24.32 10.73 14 102302 28808 50474000
Cleft lip 24.29 10.73 9 102307 104 50502704
Lymphangioleiomyomatosis 24.28 10.73 10 102306 156 50502652
Haemoglobin decreased 24.27 10.73 154 102162 127062 50375746
Rubella antibody positive 24.20 10.73 8 102308 64 50502744
Encephalitis 24.19 10.73 49 102267 7331 50495477
Influenza 24.17 10.73 96 102220 89442 50413366
Lymphopenia 24.11 10.73 78 102238 15543 50487265
Pneumonia aspiration 23.98 10.73 125 102191 30879 50471929
Paternal exposure before pregnancy 23.97 10.73 7 102309 35 50502773
Device dislocation 23.77 10.73 7 102309 21539 50481269
MELAS syndrome 23.69 10.73 9 102307 112 50502696
Poor personal hygiene 23.52 10.73 12 102304 313 50502495
Multiple organ dysfunction syndrome 23.31 10.73 178 102138 50159 50452649
Developmental delay 23.30 10.73 20 102296 1274 50501534
Magnetic resonance imaging head abnormal 23.30 10.73 23 102293 1754 50501054
Infantile apnoea 23.27 10.73 17 102299 856 50501952
Opsoclonus myoclonus 23.13 10.73 9 102307 120 50502688
Axillary lymphadenectomy 23.10 10.73 5 102311 4 50502804
Congenital knee dislocation 23.10 10.73 5 102311 4 50502804
Acquired immunodeficiency syndrome 22.81 10.73 8 102308 78 50502730
Transaminases increased 22.79 10.73 114 102202 27710 50475098
Unintended pregnancy 22.73 10.73 38 102278 4908 50497900
Cerebral venous sinus thrombosis 22.63 10.73 22 102294 1646 50501162
Eye movement disorder 22.35 10.73 36 102280 4509 50498299
Lennox-Gastaut syndrome 22.31 10.73 11 102305 266 50502542
Catastrophic reaction 22.25 10.73 6 102310 21 50502787
Blood brain barrier defect 22.19 10.73 8 102308 85 50502723
Product residue present 22.18 10.73 32 102284 3640 50499168
Blister 22.17 10.73 93 102223 85325 50417483
Quadriparesis 22.11 10.73 22 102294 1694 50501114
Heart rate irregular 21.90 10.73 6 102310 19354 50483454
Educational problem 21.78 10.73 12 102304 367 50502441
Ventricular tachycardia 21.77 10.73 76 102240 15745 50487063
CSF protein increased 21.73 10.73 13 102303 466 50502342
Pulmonary arterial hypertension 21.70 10.73 7 102309 20312 50482496
Erythema multiforme 21.67 10.73 53 102263 8997 50493811
Upper respiratory tract infection 21.61 10.73 65 102251 65833 50436975
Mental disorder 21.60 10.73 95 102221 21896 50480912
Cardiac arrest neonatal 21.55 10.73 8 102308 93 50502715
Coma blister 21.53 10.73 9 102307 146 50502662
Developmental regression 21.43 10.73 6 102310 25 50502783
Motor dysfunction 21.36 10.73 49 102267 7982 50494826
Bile acid malabsorption 21.26 10.73 9 102307 151 50502657
Type 2 diabetes mellitus 21.08 10.73 23 102293 34352 50468456
Thunderclap headache 21.04 10.73 9 102307 155 50502653
Bladder sphincter atony 20.99 10.73 9 102307 156 50502652
Necrotising enterocolitis neonatal 20.94 10.73 9 102307 157 50502651
COVID-19 20.91 10.73 39 102277 46623 50456185
Clonic convulsion 20.83 10.73 14 102302 616 50502192
Gaze palsy 20.80 10.73 19 102297 1314 50501494
Heart rate increased 20.74 10.73 83 102233 77167 50425641
Rhinorrhoea 20.66 10.73 46 102270 51537 50451271
Drowning 20.55 10.73 12 102304 411 50502397
Pregnancy on contraceptive 20.46 10.73 17 102299 1035 50501773
Psychomotor skills impaired 20.43 10.73 23 102293 2041 50500767
Intrauterine infection 20.41 10.73 8 102308 109 50502699
Unmasking of previously unidentified disease 20.40 10.73 15 102301 763 50502045
Brain herniation 20.24 10.73 28 102288 3064 50499744
Atrioventricular block complete 20.12 10.73 45 102271 7210 50495598
Head injury 20.09 10.73 99 102217 23921 50478887
Hypogammaglobulinaemia 20.08 10.73 39 102277 5660 50497148
Astrocytoma 19.98 10.73 7 102309 68 50502740
Ocular hyperaemia 19.95 10.73 8 102308 20284 50482524
Irregular sleep phase 19.93 10.73 5 102311 12 50502796
Gamma-glutamyltransferase increased 19.93 10.73 115 102201 29508 50473300
Inappropriate affect 19.91 10.73 15 102301 792 50502016
Encephalomalacia 19.89 10.73 12 102304 437 50502371
Hyperhidrosis 19.88 10.73 103 102213 89323 50413485
Ulcer 19.81 10.73 8 102308 20192 50482616
Febrile neutropenia 19.79 10.73 116 102200 97551 50405257
Bursitis 19.77 10.73 10 102306 22125 50480683
Dystonia 19.74 10.73 61 102255 11865 50490943
Pregnancy on oral contraceptive 19.72 10.73 16 102300 942 50501866
Hydrocephalus 19.67 10.73 35 102281 4753 50498055
Cyanosis neonatal 19.49 10.73 10 102306 264 50502544
Major depression 19.43 10.73 43 102273 6841 50495967
Epileptic encephalopathy 19.42 10.73 10 102306 266 50502542
Impulsive behaviour 19.35 10.73 19 102297 1439 50501369
Metastases to meninges 19.29 10.73 22 102294 1980 50500828
Ear malformation 19.24 10.73 9 102307 193 50502615
Hypoventilation 19.20 10.73 31 102285 3890 50498918
Hemianopia homonymous 19.19 10.73 13 102303 580 50502228
Vasogenic cerebral oedema 18.99 10.73 12 102304 475 50502333
Lipids 18.89 10.73 5 102311 16 50502792
Contusion 18.82 10.73 141 102175 112042 50390766
Chronic obstructive pulmonary disease 18.77 10.73 51 102265 53384 50449424
Amnesia 18.77 10.73 148 102168 42112 50460696
Creutzfeldt-Jakob disease 18.75 10.73 8 102308 137 50502671
Wrong patient 18.73 10.73 7 102309 83 50502725
Hemianopia 18.73 10.73 15 102301 867 50501941
Gastric pH increased 18.72 10.73 6 102310 43 50502765
Joint range of motion decreased 18.70 10.73 7 102309 18505 50484303
Oedema 18.47 10.73 76 102240 70105 50432703
Rhesus incompatibility 18.44 10.73 7 102309 87 50502721
Ear pain 18.39 10.73 18 102298 28265 50474543
Premature labour 18.35 10.73 58 102258 11418 50491390
Tubulointerstitial nephritis 18.33 10.73 70 102246 15141 50487667
Hiccups 18.29 10.73 20 102296 1719 50501089
Bone pain 18.20 10.73 43 102273 47186 50455622
Gestational diabetes 18.18 10.73 44 102272 7421 50495387
Accidental overdose 18.15 10.73 83 102233 19450 50483358
Tachycardia 18.14 10.73 293 102023 99470 50403338
Fall 18.08 10.73 839 101477 334093 50168715
Congenital spinal fusion 18.06 10.73 4 102312 4 50502804
Neuropathy peripheral 18.01 10.73 118 102198 96639 50406169
Petechiae 17.99 10.73 61 102255 12451 50490357
Apnoea 17.98 10.73 42 102274 6924 50495884
Burning sensation 17.81 10.73 41 102275 45405 50457403
Malabsorption 17.74 10.73 29 102287 3677 50499131
Loss of consciousness 17.70 10.73 303 102013 104050 50398758
Lymphangioma 17.64 10.73 5 102311 22 50502786
Neurosurgery 17.64 10.73 5 102311 22 50502786
Right aortic arch 17.63 10.73 9 102307 235 50502573
Unresponsive to stimuli 17.54 10.73 114 102202 30495 50472313
Osteonecrosis 17.53 10.73 12 102304 22505 50480303
Drug eruption 17.45 10.73 94 102222 23512 50479296
Tendonitis 17.41 10.73 6 102310 16699 50486109
Pyloric stenosis 17.38 10.73 10 102306 333 50502475
Radiation necrosis 17.38 10.73 10 102306 333 50502475
Oral pain 17.38 10.73 15 102301 25018 50477790
Breast cancer 17.38 10.73 38 102278 42852 50459956
Central nervous system infection 17.36 10.73 13 102303 680 50502128
Cerebral cyst 17.32 10.73 9 102307 244 50502564
Acquired macroglossia 17.26 10.73 8 102308 168 50502640
Cephalhaematoma 17.17 10.73 4 102312 6 50502802
Injection site haemorrhage 17.13 10.73 11 102305 21335 50481473
Amniorrhexis 17.12 10.73 5 102311 25 50502783
Diabetes mellitus 17.07 10.73 47 102269 48986 50453822
Femur fracture 17.06 10.73 31 102285 37433 50465375
Intrusive thoughts 17.00 10.73 8 102308 174 50502634
Sinus bradycardia 17 10.73 62 102254 13121 50489687
Wrong product administered 16.87 10.73 35 102281 5325 50497483
Localised infection 16.82 10.73 16 102300 25469 50477339
Brain neoplasm malignant 16.70 10.73 14 102302 863 50501945
Lethargy 16.69 10.73 163 102153 49269 50453539
Hypocalcaemia 16.69 10.73 102 102214 26714 50476094
Cardiac disorder 16.66 10.73 39 102277 42940 50459868
Lipids abnormal 16.65 10.73 9 102307 265 50502543
Spinal osteoarthritis 16.64 10.73 4 102312 14088 50488720
Haemorrhage intracranial 16.64 10.73 59 102257 12315 50490493
Angina pectoris 16.64 10.73 17 102299 26171 50476637
Dry mouth 16.62 10.73 58 102258 56120 50446688
Eye irritation 16.46 10.73 7 102309 17133 50485675
Headache 16.44 10.73 847 101469 505688 49997120
Staphylococcal scalded skin syndrome 16.34 10.73 7 102309 121 50502687
Euthyroid sick syndrome 16.30 10.73 6 102310 68 50502740
Crying 16.26 10.73 83 102233 20333 50482475
Injection site warmth 16.25 10.73 4 102312 13862 50488946
Tooth disorder 16.24 10.73 15 102301 24213 50478595
Theft 16.22 10.73 6 102310 69 50502739
Drug level below therapeutic 16.22 10.73 28 102288 3712 50499096
Craniotomy 16.21 10.73 8 102308 194 50502614
Musculoskeletal discomfort 16.15 10.73 5 102311 14893 50487915
Plasma cell myeloma 16.05 10.73 24 102292 31298 50471510
Placental disorder 16.01 10.73 17 102299 1413 50501395
Subdural haematoma 15.95 10.73 60 102256 12887 50489921
Blood glucose increased 15.93 10.73 82 102234 71242 50431566
Sudden infant death syndrome 15.84 10.73 8 102308 204 50502604
Haemoptysis 15.80 10.73 17 102299 25556 50477252
Oscillopsia 15.79 10.73 7 102309 132 50502676
Food interaction 15.76 10.73 12 102304 644 50502164
Laryngeal stenosis 15.75 10.73 13 102303 784 50502024
Precocious puberty 15.70 10.73 8 102308 208 50502600
Hypoaesthesia 15.66 10.73 173 102143 127084 50375724
Intestinal atresia 15.62 10.73 3 102313 0 50502808
Neurological decompensation 15.53 10.73 21 102295 2249 50500559
Chills 15.53 10.73 123 102193 96564 50406244
Injection site urticaria 15.38 10.73 3 102313 12214 50490594
Injection site bruising 15.38 10.73 32 102284 36736 50466072
Abulia 15.36 10.73 10 102306 417 50502391
Hyperkalaemia 15.36 10.73 48 102268 48041 50454767
Anaphylactic shock 15.35 10.73 11 102305 20144 50482664
Macular degeneration 15.29 10.73 5 102311 14383 50488425
Hyperthermia 15.27 10.73 42 102274 7654 50495154
Respiratory syncytial virus bronchiolitis 15.24 10.73 9 102307 315 50502493
Product prescribing error 15.18 10.73 83 102233 20878 50481930
Pulmonary valve stenosis congenital 15.14 10.73 7 102309 146 50502662
Nosocomial infection 15.13 10.73 17 102299 1505 50501303
Nervous system disorder 15.12 10.73 69 102247 16154 50486654
Hypernatraemia 15.12 10.73 37 102279 6284 50496524
Mitochondrial cytopathy 15.06 10.73 8 102308 227 50502581
Juvenile myoclonic epilepsy 15.06 10.73 4 102312 13 50502795
Diabetes mellitus inadequate control 15.01 10.73 4 102312 13141 50489667
Lactation disorder 14.98 10.73 9 102307 325 50502483
Injection site rash 14.92 10.73 7 102309 16170 50486638
Anticonvulsant drug level abnormal 14.91 10.73 5 102311 42 50502766
Congenital arterial malformation 14.91 10.73 9 102307 328 50502480
Feeling abnormal 14.89 10.73 172 102144 125320 50377488
Neck pain 14.89 10.73 62 102254 57005 50445803
Asterixis 14.85 10.73 15 102301 1176 50501632
Device malfunction 14.81 10.73 6 102310 15115 50487693
Multiple sclerosis 14.74 10.73 81 102235 20412 50482396
Product use issue 14.74 10.73 213 102103 149262 50353546
Nodule 14.72 10.73 8 102308 16995 50485813
Drug exposure before pregnancy 14.64 10.73 12 102304 717 50502091
Blood creatinine increased 14.62 10.73 92 102224 76068 50426740
Drug dose titration not performed 14.60 10.73 10 102306 454 50502354
Hostility 14.56 10.73 18 102298 1764 50501044
Carpal tunnel syndrome 14.55 10.73 8 102308 16885 50485923
Sialoadenitis 14.55 10.73 16 102300 1384 50501424
Polychromasia 14.54 10.73 6 102310 94 50502714
Cardiac failure 14.52 10.73 92 102224 75948 50426860
Tooth abscess 14.52 10.73 4 102312 12856 50489952
Mucocutaneous rash 14.42 10.73 4 102312 16 50502792
Illness 14.41 10.73 17 102299 24523 50478285
Cell death 14.41 10.73 20 102296 2195 50500613
Pleural effusion 14.33 10.73 101 102215 81353 50421455
Amylase increased 14.30 10.73 33 102283 5397 50497411
Pregnancy with implant contraceptive 14.27 10.73 19 102297 2004 50500804
Medication error 14.19 10.73 123 102193 35981 50466827
Psychiatric decompensation 14.16 10.73 15 102301 1243 50501565
Glycosuria 14.05 10.73 14 102302 1080 50501728
Rebound effect 13.99 10.73 24 102292 3165 50499643
Eye pruritus 13.96 10.73 4 102312 12530 50490278
Neonatal seizure 13.87 10.73 9 102307 373 50502435
Gastric disorder 13.86 10.73 24 102292 29524 50473284
Inappropriate antidiuretic hormone secretion 13.85 10.73 58 102258 13085 50489723
Threatened labour 13.84 10.73 12 102304 775 50502033
Urine amphetamine positive 13.80 10.73 5 102311 54 50502754
Throat irritation 13.79 10.73 25 102291 30214 50472594
Asthenia 13.73 10.73 517 101799 318525 50184283
Illusion 13.68 10.73 13 102303 946 50501862
Coma acidotic 13.64 10.73 6 102310 111 50502697
Automatism 13.64 10.73 5 102311 56 50502752
Cleft palate 13.63 10.73 13 102303 950 50501858
Refusal of treatment by patient 13.63 10.73 31 102285 5022 50497786
Placental infarction 13.62 10.73 8 102308 277 50502531
Perforation 13.62 10.73 13 102303 951 50501857
Infantile haemangioma 13.56 10.73 5 102311 57 50502751
Cerebrosclerosis 13.54 10.73 3 102313 3 50502805
Drop attacks 13.51 10.73 11 102305 651 50502157
Laryngomalacia 13.48 10.73 5 102311 58 50502750
Microcephaly 13.46 10.73 12 102304 804 50502004
QRS axis abnormal 13.46 10.73 13 102303 965 50501843
Dementia 13.42 10.73 66 102250 15931 50486877
Cerebral artery stenosis 13.41 10.73 9 102307 395 50502413
Cyst 13.37 10.73 4 102312 12183 50490625
Illogical thinking 13.33 10.73 5 102311 60 50502748
Disorganised speech 13.31 10.73 13 102303 978 50501830
Postmature baby 13.30 10.73 6 102310 118 50502690
Shunt malfunction 13.25 10.73 5 102311 61 50502747
Primary mediastinal large B-cell lymphoma 13.23 10.73 4 102312 23 50502785
Abortion threatened 13.19 10.73 10 102306 533 50502275
Tooth infection 13.18 10.73 6 102310 14106 50488702
Acute disseminated encephalomyelitis 13.17 10.73 7 102309 199 50502609
Product administered to patient of inappropriate age 13.16 10.73 21 102295 2609 50500199
Metabolic acidosis 13.10 10.73 128 102188 38697 50464111
Hypertransaminasaemia 13.07 10.73 25 102291 3586 50499222
Dysgeusia 13.03 10.73 38 102278 38878 50463930
Hepatitis viral 13.02 10.73 9 102307 415 50502393
Intensive care unit acquired weakness 13.01 10.73 11 102305 686 50502122
Polydactyly 12.98 10.73 8 102308 303 50502505
Herpes simplex encephalitis 12.95 10.73 8 102308 304 50502504
Sinus disorder 12.89 10.73 11 102305 18447 50484361
Neonatal disorder 12.89 10.73 10 102306 552 50502256
Radiation skin injury 12.88 10.73 12 102304 851 50501957
Surgery 12.87 10.73 26 102290 30179 50472629
Normal newborn 12.77 10.73 36 102280 6655 50496153
Teratoma 12.73 10.73 6 102310 131 50502677
Hiatus hernia 12.72 10.73 11 102305 18333 50484475
Hypersomnia 12.72 10.73 63 102253 15251 50487557
Mitral valve incompetence 12.71 10.73 10 102306 17461 50485347
Device issue 12.65 10.73 13 102303 19959 50482849
Motor developmental delay 12.57 10.73 6 102310 135 50502673
High-pitched crying 12.56 10.73 4 102312 28 50502780
Diverticulum 12.56 10.73 3 102313 10611 50492197
Pain in jaw 12.53 10.73 38 102278 38390 50464418
Papilloedema 12.52 10.73 24 102292 3449 50499359
Catatonia 12.48 10.73 25 102291 3711 50499097
Hemiplegia 12.44 10.73 38 102278 7343 50495465
Product dose omission issue 12.42 10.73 280 102036 183558 50319250
Growth retardation 12.40 10.73 13 102303 1065 50501743
Cerebral haemorrhage neonatal 12.37 10.73 6 102310 140 50502668
Glycogen storage disorder 12.33 10.73 3 102313 6 50502802
Attention-seeking behaviour 12.32 10.73 5 102311 75 50502733
Emotional disorder 12.29 10.73 52 102264 11784 50491024
Rotator cuff syndrome 12.29 10.73 4 102312 11540 50491268
Tongue injury 12.28 10.73 8 102308 334 50502474
Premature rupture of membranes 12.24 10.73 28 102288 4552 50498256
Platelet count decreased 12.20 10.73 278 102038 100448 50402360
Cerebral atrophy 12.16 10.73 28 102288 4573 50498235
Developmental hip dysplasia 12.13 10.73 14 102302 1277 50501531
Gliosis 12.09 10.73 7 102309 236 50502572
Coma hepatic 12.08 10.73 10 102306 606 50502202
Accessory auricle 12.02 10.73 3 102313 7 50502801
Faeces discoloured 12.02 10.73 9 102307 16115 50486693
Atrial septal defect 11.98 10.73 34 102282 6307 50496501
Congenital anomaly 11.85 10.73 15 102301 1506 50501302
Carnitine deficiency 11.85 10.73 6 102310 154 50502654
Anotia 11.74 10.73 3 102313 8 50502800
Temporal lobe epilepsy 11.71 10.73 8 102308 362 50502446
Patient uncooperative 11.71 10.73 6 102310 158 50502650
Eye pain 11.69 10.73 25 102291 28424 50474384
Pulmonary oedema 11.66 10.73 55 102261 48883 50453925
Throat tightness 11.66 10.73 15 102301 20832 50481976
Nail dystrophy 11.58 10.73 11 102305 800 50502008
Grip strength decreased 11.56 10.73 5 102311 12116 50490692
Intracranial hypotension 11.55 10.73 7 102309 257 50502551
Weight decreased 11.50 10.73 350 101966 220895 50281913
Sinus congestion 11.48 10.73 7 102309 13964 50488844
Aspiration 11.47 10.73 43 102273 9221 50493587
Ventricular fibrillation 11.44 10.73 47 102269 10512 50492296
Mixed liver injury 11.41 10.73 23 102293 3428 50499380
Blepharospasm 11.41 10.73 21 102295 2927 50499881
Intracranial pressure increased 11.37 10.73 26 102290 4226 50498582
Renal impairment 11.35 10.73 98 102218 75563 50427245
Postictal paralysis 11.34 10.73 5 102311 93 50502715
Anti-GAD antibody positive 11.31 10.73 4 102312 40 50502768
Tension headache 11.26 10.73 20 102296 2711 50500097
Intensive care unit delirium 11.23 10.73 4 102312 41 50502767
Irregular sleep wake rhythm disorder 11.21 10.73 6 102310 173 50502635
Basilar migraine 11.14 10.73 4 102312 42 50502766
Amniocentesis abnormal 11.05 10.73 5 102311 99 50502709
Multiple congenital abnormalities 11.03 10.73 9 102307 534 50502274
Self-medication 11.02 10.73 18 102298 2281 50500527
Foetal death 11.00 10.73 39 102277 8141 50494667
Haematoma 10.99 10.73 102 102214 30408 50472400
Optic nerve disorder 10.98 10.73 10 102306 689 50502119
Tonsillar hypertrophy 10.97 10.73 11 102305 855 50501953
Potentiating drug interaction 10.95 10.73 24 102292 3792 50499016
Lactic acidosis 10.86 10.73 33 102283 33322 50469486
Hypertelorism 10.84 10.73 8 102308 409 50502399
Skin disorder 10.84 10.73 20 102296 24010 50478798
Dropped head syndrome 10.83 10.73 5 102311 104 50502704
Biopsy brain 10.81 10.73 3 102313 12 50502796
Eyelid injury 10.81 10.73 3 102313 12 50502796
Toe walking 10.81 10.73 3 102313 12 50502796
Exostosis 10.81 10.73 5 102311 11648 50491160
Cold sweat 10.79 10.73 4 102312 10640 50492168
Periodic limb movement disorder 10.79 10.73 6 102310 187 50502621
Glioma 10.77 10.73 7 102309 291 50502517
Arteriovenous malformation 10.75 10.73 13 102303 1245 50501563

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Seizure 3819.66 10.88 2705 83524 90418 29397880
Status epilepticus 1549.15 10.88 714 85515 10080 29478218
Generalised tonic-clonic seizure 865.96 10.88 593 85636 18546 29469752
Epilepsy 733.48 10.88 528 85701 17904 29470394
Partial seizures 531.03 10.88 249 85980 3654 29484644
Multiple-drug resistance 458.27 10.88 225 86004 3675 29484623
Aggression 429.91 10.88 524 85705 35017 29453281
Foetal exposure during pregnancy 394.55 10.88 490 85739 33377 29454921
Product substitution issue 386.01 10.88 272 85957 8900 29479398
Drug ineffective 323.77 10.88 1981 84248 361189 29127109
Somnolence 295.98 10.88 765 85464 93190 29395108
Dyspnoea 285.89 10.88 320 85909 326412 29161886
Drug reaction with eosinophilia and systemic symptoms 268.33 10.88 368 85861 27624 29460674
Psychogenic seizure 246.67 10.88 75 86154 283 29488015
Maternal exposure during pregnancy 213.36 10.88 139 86090 3984 29484314
Cytokine release syndrome 212.14 10.88 225 86004 12894 29475404
Cognitive disorder 201.57 10.88 293 85936 23206 29465092
Focal dyscognitive seizures 186.64 10.88 85 86144 1161 29487137
Drug withdrawal convulsions 182.78 10.88 82 86147 1079 29487219
Myocardial infarction 180.83 10.88 49 86180 110247 29378051
Aura 165.44 10.88 54 86175 270 29488028
Encephalopathy 162.43 10.88 310 85919 30733 29457565
Hyperammonaemia 156.91 10.88 131 86098 5532 29482766
Petit mal epilepsy 156.31 10.88 98 86131 2624 29485674
Irritability 151.79 10.88 249 85980 21903 29466395
Behaviour disorder 146.94 10.88 105 86124 3511 29484787
Rhabdomyolysis 145.94 10.88 449 85780 60359 29427939
Aphasia 145.56 10.88 226 86003 18972 29469326
Agitation 144.38 10.88 401 85828 50903 29437395
Sudden unexplained death in epilepsy 143.67 10.88 53 86176 403 29487895
Myoclonic epilepsy 138.17 10.88 64 86165 911 29487387
Arthralgia 136.14 10.88 124 86105 139493 29348805
Diarrhoea 132.74 10.88 511 85718 332187 29156111
Ataxia 131.11 10.88 169 86060 11934 29476364
Abnormal behaviour 128.50 10.88 237 85992 22890 29465408
Myoclonus 123.01 10.88 172 86057 13137 29475161
Maternal drugs affecting foetus 120.36 10.88 96 86133 3797 29484501
Postictal psychosis 117.75 10.88 36 86193 139 29488159
Cardiac failure congestive 116.43 10.88 39 86190 76542 29411756
Hepatocellular injury 112.16 10.88 213 86016 21030 29467268
Glioblastoma 104.86 10.88 53 86176 923 29487375
Pain 97.30 10.88 223 86006 171209 29317089
Anticonvulsant drug level decreased 96.97 10.88 51 86178 968 29487330
Electroencephalogram abnormal 95.33 10.88 68 86161 2267 29486031
Anticonvulsant drug level increased 94.94 10.88 57 86172 1409 29486889
Exposure via breast milk 91.73 10.88 59 86170 1653 29486645
Confusional state 91.39 10.88 662 85567 127215 29361083
Brain malformation 89.82 10.88 27 86202 97 29488201
Chest pain 87.63 10.88 119 86110 111854 29376444
Back pain 87.02 10.88 102 86127 102182 29386116
Developmental delay 86.30 10.88 66 86163 2452 29485846
Immune effector cell-associated neurotoxicity syndrome 82.84 10.88 53 86176 1471 29486827
Pain in extremity 82.80 10.88 121 86108 110312 29377986
Hemiparesis 82.41 10.88 150 86079 14336 29473962
Seizure cluster 81.27 10.88 25 86204 99 29488199
No adverse event 79.90 10.88 165 86064 17313 29470985
Premature baby 78.84 10.88 163 86066 17117 29471181
Infantile spasms 78.63 10.88 27 86202 162 29488136
Coronary artery disease 77.48 10.88 17 86212 44173 29444125
Rheumatoid arthritis 77.17 10.88 4 86225 32148 29456150
Psychotic disorder 74.76 10.88 176 86053 20178 29468120
Pneumonia aspiration 73.42 10.88 255 85974 36482 29451816
Anticonvulsant drug level above therapeutic 73.09 10.88 35 86194 539 29487759
Anticonvulsant drug level below therapeutic 73.07 10.88 36 86193 592 29487706
Brain oedema 72.66 10.88 129 86100 12091 29476207
Anger 71.34 10.88 120 86109 10770 29477528
Stupor 70.93 10.88 61 86168 2683 29485615
Atrial fibrillation 69.59 10.88 126 86103 105520 29382778
Drug resistance 69.28 10.88 177 86052 21363 29466935
Joint swelling 69.17 10.88 29 86200 49601 29438697
Low birth weight baby 68.03 10.88 90 86139 6518 29481780
Gastrointestinal haemorrhage 67.96 10.88 79 86150 79454 29408844
Malaise 67.39 10.88 239 85990 159363 29328935
Partial seizures with secondary generalisation 67.16 10.88 26 86203 229 29488069
Off label use 66.20 10.88 1237 84992 299563 29188735
Nystagmus 64.55 10.88 71 86158 4238 29484060
Encephalitis autoimmune 63.85 10.88 31 86198 493 29487805
Drug ineffective for unapproved indication 63.57 10.88 133 86096 14081 29474217
Hyperammonaemic encephalopathy 63.50 10.88 50 86179 1940 29486358
Tonic convulsion 62.19 10.88 37 86192 899 29487399
Neurological decompensation 62.16 10.88 54 86175 2408 29485890
Cough 61.70 10.88 178 86051 126549 29361749
Cholestasis 60.70 10.88 178 86051 23284 29465014
Drug interaction 60.62 10.88 858 85371 196527 29291771
Memory impairment 59.38 10.88 237 85992 36233 29452065
Glioblastoma multiforme 59.12 10.88 32 86197 645 29487653
Sedation 59.09 10.88 146 86083 17259 29471039
Atrial septal defect 57.23 10.88 84 86145 6705 29481593
Eosinophilia 57.21 10.88 168 86061 21993 29466305
Neuropathy peripheral 57.04 10.88 74 86155 70953 29417345
Drug level decreased 56.62 10.88 80 86149 6167 29482131
Cryptorchism 56.03 10.88 46 86183 1896 29486402
Brain neoplasm 55.94 10.88 54 86175 2762 29485536
Dysmorphism 55.33 10.88 55 86174 2916 29485382
Pneumonia 54.74 10.88 634 85595 319538 29168760
Nausea 54.54 10.88 560 85669 288695 29199603
Death 54.46 10.88 688 85541 341396 29146902
Delirium 54.04 10.88 243 85986 39154 29449144
Cerebral cyst 53.19 10.88 22 86207 234 29488064
Anaemia 52.84 10.88 356 85873 200595 29287703
Hypotonia neonatal 52.70 10.88 37 86192 1202 29487096
Psychiatric symptom 52.15 10.88 55 86174 3129 29485169
Acute myocardial infarction 52.10 10.88 39 86190 48399 29439899
Rash maculo-papular 51.51 10.88 172 86057 24117 29464181
Stevens-Johnson syndrome 51.43 10.88 134 86095 16363 29471935
Thrombocytopenia 51.41 10.88 610 85619 134213 29354085
Toxic epidermal necrolysis 51.11 10.88 142 86087 18011 29470287
Myalgia 50.79 10.88 86 86143 73933 29414365
Suicidal ideation 50.55 10.88 218 86011 34498 29453800
Small for dates baby 50.23 10.88 57 86172 3522 29484776
Chest discomfort 49.49 10.88 37 86192 45946 29442352
Chronic obstructive pulmonary disease 49.42 10.88 29 86200 40926 29447372
Glomerulonephritis minimal lesion 49.24 10.88 24 86205 385 29487913
Coordination abnormal 47.41 10.88 79 86150 7035 29481263
Speech disorder developmental 46.48 10.88 41 86188 1866 29486432
Brain operation 46.16 10.88 21 86208 286 29488012
Affective disorder 45.95 10.88 51 86178 3075 29485223
Muscle twitching 45.51 10.88 83 86146 7943 29480355
Simple partial seizures 45.35 10.88 20 86209 252 29488046
Condition aggravated 45.27 10.88 637 85592 145658 29342640
Selective eating disorder 45.09 10.88 38 86191 1625 29486673
Neurotoxicity 44.84 10.88 118 86111 14495 29473803
Abdominal pain 44.53 10.88 223 86006 135134 29353164
Hamartoma 44.07 10.88 13 86216 43 29488255
Pleural effusion 43.63 10.88 90 86139 71818 29416480
Mood altered 43.63 10.88 82 86147 8029 29480269
Personality change 42.93 10.88 60 86169 4578 29483720
Paradoxical drug reaction 42.51 10.88 46 86183 2695 29485603
Irregular sleep phase 41.77 10.88 13 86216 54 29488244
Oedema peripheral 41.73 10.88 158 86071 103399 29384899
Gait disturbance 41.47 10.88 360 85869 72989 29415309
Cardiac failure 41.07 10.88 108 86121 79179 29409119
Ventricular septal defect 40.94 10.88 51 86178 3478 29484820
Productive cough 40.84 10.88 20 86209 31239 29457059
Autonomic nervous system imbalance 40.63 10.88 42 86187 2334 29485964
Prostate cancer 40.55 10.88 12 86217 25515 29462783
Haemoglobin decreased 40.11 10.88 171 86058 108204 29380094
Gaze palsy 40.08 10.88 32 86197 1267 29487031
Depressive symptom 40.03 10.88 36 86193 1681 29486617
Neonatal pneumonia 40.00 10.88 15 86214 120 29488178
Overdose 39.66 10.88 381 85848 79438 29408860
Interstitial lung disease 39.64 10.88 67 86162 57651 29430647
Blood creatinine increased 39.61 10.88 122 86107 84980 29403318
Change in seizure presentation 39.34 10.88 13 86216 68 29488230
Arthritis 39.31 10.88 12 86217 25007 29463291
Hyponatraemia 39.31 10.88 334 85895 67299 29420999
Accidental death 39.06 10.88 39 86190 2079 29486219
Disorientation 38.94 10.88 180 86049 29335 29458963
Depressed level of consciousness 38.65 10.88 211 86018 36731 29451567
Blood pressure increased 38.63 10.88 100 86129 73703 29414595
Atonic seizures 38.53 10.88 16 86213 172 29488126
Diabetes insipidus 38.02 10.88 41 86188 2393 29485905
Drug withdrawal syndrome neonatal 37.69 10.88 48 86181 3347 29484951
Angina pectoris 37.64 10.88 17 86212 27833 29460465
Febrile convulsion 37.41 10.88 22 86207 523 29487775
Dyspnoea exertional 37.20 10.88 31 86198 36459 29451839
Polydactyly 37.15 10.88 29 86200 1111 29487187
Disturbance in attention 37.12 10.88 142 86087 21282 29467016
Convulsive threshold lowered 36.36 10.88 21 86208 482 29487816
Melaena 36.32 10.88 23 86206 31153 29457145
Febrile neutropenia 36.28 10.88 186 86043 112054 29376244
Psychomotor hyperactivity 35.74 10.88 76 86153 8137 29480161
Intensive care unit acquired weakness 35.17 10.88 26 86203 917 29487381
Chills 34.77 10.88 100 86129 71200 29417098
Neonatal infection 34.62 10.88 19 86210 394 29487904
Suicide attempt 34.46 10.88 193 86036 33917 29454381
Propofol infusion syndrome 34.09 10.88 24 86205 783 29487515
Asthenia 33.73 10.88 434 85795 214816 29273482
Plasmapheresis 33.69 10.88 17 86212 295 29488003
Postictal state 33.59 10.88 23 86206 717 29487581
Abdominal discomfort 33.45 10.88 55 86174 47848 29440450
Congenital hypoplasia of depressor angularis oris muscle 33.20 10.88 8 86221 8 29488290
Abdominal pain upper 33.19 10.88 81 86148 60912 29427386
Hypothermia 32.95 10.88 79 86150 9160 29479138
Acute psychosis 32.85 10.88 32 86197 1655 29486643
Fluid retention 32.44 10.88 14 86215 23546 29464752
Maternal exposure during breast feeding 32.39 10.88 30 86199 1456 29486842
Mental status changes 32.28 10.88 193 86036 34734 29453564
Inappropriate antidiuretic hormone secretion 32.25 10.88 87 86142 10845 29477453
Psoriasis 32.09 10.88 28 86201 32199 29456099
International normalised ratio increased 31.88 10.88 50 86179 44322 29443976
Psoriatic arthropathy 31.87 10.88 3 86226 14688 29473610
Necrosis ischaemic 31.80 10.88 15 86214 223 29488075
Coma blister 31.62 10.88 11 86218 69 29488229
Balance disorder 31.61 10.88 197 86032 35973 29452325
Blood glucose increased 31.57 10.88 79 86150 58905 29429393
Postictal paralysis 31.50 10.88 15 86214 228 29488070
Neuropsychiatric symptoms 31.45 10.88 19 86210 475 29487823
Autism spectrum disorder 31.34 10.88 34 86195 1998 29486300
Hypospadias 31.07 10.88 41 86188 2961 29485337
Neonatal hypotension 31.04 10.88 13 86216 143 29488155
Clonic convulsion 30.94 10.88 20 86209 565 29487733
Product administration error 30.92 10.88 102 86127 14208 29474090
Acidosis hyperchloraemic 30.91 10.88 17 86212 354 29487944
Delusion 30.85 10.88 87 86142 11129 29477169
Cardiac disorder 30.76 10.88 38 86191 37225 29451073
Cerebellar ataxia 30.60 10.88 24 86205 926 29487372
Plasma cell myeloma 30.48 10.88 38 86191 37077 29451221
Syndactyly 30.33 10.88 22 86207 753 29487545
Injection site pain 30.17 10.88 30 86199 32416 29455882
Psychomotor disadaptation syndrome 30.13 10.88 7 86222 5 29488293
Infusion related reaction 30.08 10.88 51 86178 43835 29444463
Infantile apnoea 29.90 10.88 23 86206 862 29487436
Hyperhidrosis 29.68 10.88 93 86136 64447 29423851
Sinusitis 29.45 10.88 34 86195 34316 29453982
Haemophagocytic lymphohistiocytosis 29.40 10.88 82 86147 10422 29477876
Terminal insomnia 29.25 10.88 17 86212 395 29487903
Altered state of consciousness 29.02 10.88 125 86104 19764 29468534
Hallucination, visual 28.92 10.88 103 86126 14912 29473386
Attention deficit hyperactivity disorder 28.91 10.88 34 86195 2183 29486115
Lymphopenia 28.83 10.88 96 86133 13437 29474861
Non-24-hour sleep-wake disorder 28.76 10.88 8 86221 20 29488278
Cardiogenic shock 28.75 10.88 10 86219 19180 29469118
Oculogyric crisis 28.74 10.88 27 86202 1334 29486964
Haemoptysis 28.69 10.88 28 86201 30522 29457776
Eye movement disorder 28.68 10.88 44 86185 3652 29484646
Congenital nail disorder 28.61 10.88 9 86220 39 29488259
Staring 28.44 10.88 27 86202 1352 29486946
Paraplegia 28.40 10.88 36 86193 2498 29485800
Pulmonary oedema 28.07 10.88 51 86178 42684 29445614
Hallucination, auditory 27.95 10.88 76 86153 9517 29478781
Postmature baby 27.70 10.88 7 86222 10 29488288
Respiratory disorder neonatal 27.69 10.88 27 86202 1398 29486900
Neonatal respiratory distress syndrome 27.68 10.88 44 86185 3766 29484532
Paranoia 27.54 10.88 77 86152 9800 29478498
Organic brain syndrome 27.53 10.88 14 86215 247 29488051
Encephalitis 27.40 10.88 59 86170 6371 29481927
Failure to suspend medication 27.37 10.88 16 86213 376 29487922
Hyperkalaemia 27.16 10.88 90 86139 61302 29426996
Peripheral swelling 27.14 10.88 95 86134 63644 29424654
Nasal septum disorder 26.94 10.88 9 86220 49 29488249
Single umbilical artery 26.93 10.88 13 86216 204 29488094
Hypotonia 26.78 10.88 61 86168 6841 29481457
Hypertransaminasaemia 26.69 10.88 42 86187 3564 29484734
Influenza 26.61 10.88 51 86178 41830 29446468
Renal failure 26.40 10.88 220 86009 118379 29369919
Arthropathy 26.37 10.88 15 86214 21539 29466759
Blepharospasm 26.35 10.88 23 86206 1032 29487266
Hydrocephalus 26.13 10.88 46 86183 4281 29484017
Mood swings 25.86 10.88 62 86167 7189 29481109
Tubulointerstitial nephritis 25.83 10.88 111 86118 17532 29470766
Anencephaly 25.72 10.88 11 86218 128 29488170
Developmental regression 25.56 10.88 8 86221 34 29488264
Brain abscess 25.55 10.88 35 86194 2620 29485678
Pruritus 25.45 10.88 218 86011 116631 29371667
Pulmonary fibrosis 25.35 10.88 7 86222 15575 29472723
Excessive eye blinking 25.33 10.88 16 86213 434 29487864
Suicidal behaviour 24.92 10.88 25 86204 1340 29486958
Nasopharyngitis 24.69 10.88 90 86139 59575 29428723
Thinking abnormal 24.59 10.88 50 86179 5186 29483112
Anomaly of external ear congenital 24.55 10.88 10 86219 102 29488196
Bradycardia neonatal 24.51 10.88 21 86208 919 29487379
Drop attacks 24.49 10.88 17 86212 542 29487756
Asthma 24.45 10.88 38 86191 33811 29454487
Administration site discomfort 24.35 10.88 8 86221 41 29488257
Idiopathic generalised epilepsy 24.35 10.88 8 86221 41 29488257
Acoustic stimulation tests abnormal 24.33 10.88 9 86220 69 29488229
Blood creatine phosphokinase increased 24.28 10.88 202 86027 40442 29447856
Blood pressure fluctuation 24.12 10.88 14 86215 19880 29468418
Posterior reversible encephalopathy syndrome 24.07 10.88 69 86160 8907 29479391
Limb reduction defect 24.06 10.88 13 86216 261 29488037
Diabetes mellitus 24.02 10.88 50 86179 39781 29448517
Foetal growth restriction 24.00 10.88 41 86188 3725 29484573
Ascites 23.79 10.88 44 86185 36575 29451723
Treatment noncompliance 23.76 10.88 136 86093 24091 29464207
COVID-19 23.64 10.88 43 86186 35971 29452327
Mucosal ulceration 23.48 10.88 20 86209 868 29487430
Neonatal tachypnoea 23.41 10.88 11 86218 162 29488136
Metastases to central nervous system 23.34 10.88 59 86170 7072 29481226
Bradyphrenia 23.16 10.88 43 86186 4171 29484127
Acute kidney injury 23.09 10.88 593 85636 264674 29223624
Speech disorder 23.05 10.88 132 86097 23384 29464914
Weight decreased 22.96 10.88 306 85923 150599 29337699
Anaphylactic reaction 22.88 10.88 28 86201 27545 29460753
Toxic encephalopathy 22.81 10.88 45 86184 4567 29483731
Rash morbilliform 22.70 10.88 32 86197 2461 29485837
Muscle spasms 22.66 10.88 105 86124 64977 29423321
Congenital hydrocephalus 22.61 10.88 9 86220 86 29488212
Cerebral haemorrhage 22.55 10.88 163 86066 31263 29457035
Psychomotor skills impaired 22.54 10.88 33 86196 2628 29485670
Leukopenia 22.43 10.88 253 85976 54950 29433348
Purple glove syndrome 22.25 10.88 8 86221 56 29488242
Altered pitch perception 22.17 10.88 6 86223 13 29488285
Craniocerebral injury 22.10 10.88 33 86196 2675 29485623
Maternal exposure before pregnancy 21.87 10.88 15 86214 469 29487829
Burnout syndrome 21.86 10.88 10 86219 138 29488160
Gout 21.81 10.88 11 86218 16900 29471398
Cardiopulmonary failure 21.81 10.88 39 86190 3675 29484623
Persecutory delusion 21.79 10.88 29 86200 2112 29486186
Asterixis 21.75 10.88 21 86208 1074 29487224
Prostatic specific antigen increased 21.68 10.88 5 86224 12559 29475739
Synovitis 21.68 10.88 3 86226 10887 29477411
Cerebellar syndrome 21.61 10.88 28 86201 1986 29486312
Madarosis 21.49 10.88 11 86218 197 29488101
Ehlers-Danlos syndrome 21.44 10.88 7 86222 35 29488263
Urge incontinence 21.37 10.88 15 86214 487 29487811
Necrotising enterocolitis neonatal 21.34 10.88 11 86218 200 29488098
Thrombosis 21.25 10.88 60 86169 42985 29445313
Cardiac septal hypertrophy 21.15 10.88 12 86217 266 29488032
Hypertension 20.97 10.88 228 86001 116386 29371912
Gliosis 20.94 10.88 10 86219 153 29488145
Osteonecrosis of jaw 20.91 10.88 11 86218 16499 29471799
Pulmonary embolism 20.85 10.88 134 86095 76400 29411898
Impulsive behaviour 20.83 10.88 27 86202 1916 29486382
Alcohol use disorder 20.78 10.88 6 86223 18 29488280
Rash scarlatiniform 20.72 10.88 9 86220 109 29488189
Contraindicated product administered 20.56 10.88 14 86215 18252 29470046
Slow response to stimuli 20.54 10.88 17 86212 709 29487589
Blood glucose decreased 20.44 10.88 5 86224 12064 29476234
Laboratory test abnormal 20.39 10.88 14 86215 18171 29470127
Affect lability 20.33 10.88 36 86193 3366 29484932
Herpes simplex encephalitis 20.12 10.88 12 86217 293 29488005
Stillbirth 20.10 10.88 10 86219 168 29488130
Tuberous sclerosis complex 20.08 10.88 6 86223 21 29488277
Completed suicide 19.80 10.88 168 86061 90078 29398220
Iris adhesions 19.67 10.88 11 86218 237 29488061
Bone pain 19.65 10.88 15 86214 18437 29469861
Poor sucking reflex 19.62 10.88 12 86217 307 29487991
Apallic syndrome 19.54 10.88 11 86218 240 29488058
Ammonia increased 19.54 10.88 39 86190 3992 29484306
Personality disorder 19.47 10.88 20 86209 1103 29487195
Dysmetria 19.45 10.88 13 86216 389 29487909
Angina unstable 19.41 10.88 4 86225 10861 29477437
Aplasia 19.32 10.88 39 86190 4024 29484274
Chronic kidney disease 19.31 10.88 49 86180 36367 29451931
Dyskinesia 19.27 10.88 112 86117 19949 29468349
Lung disorder 19.26 10.88 37 86192 30325 29457973
Agnosia 19.23 10.88 7 86222 51 29488247
Agranulocytosis 19.17 10.88 113 86116 20227 29468071
Wheezing 18.99 10.88 43 86186 33197 29455101
Autoimmune thyroiditis 18.96 10.88 19 86210 1017 29487281
Wrong patient received product 18.89 10.88 28 86201 2254 29486044
Night sweats 18.83 10.88 10 86219 14922 29473376
Hostility 18.79 10.88 17 86212 800 29487498
Mental disorder 18.74 10.88 81 86148 12824 29475474
Drug withdrawal headache 18.74 10.88 5 86224 10 29488288
Renal disorder 18.69 10.88 23 86206 22572 29465726
Micturition frequency decreased 18.63 10.88 10 86219 198 29488100
Parkinsonism 18.61 10.88 55 86174 7223 29481075
Drug hypersensitivity 18.52 10.88 120 86109 68286 29420012
Bicuspid aortic valve 18.15 10.88 10 86219 209 29488089
Hypernatraemia 18.11 10.88 55 86174 7331 29480967
Squamous cell carcinoma of skin 18.00 10.88 3 86226 9483 29478815
Caesarean section 17.98 10.88 25 86204 1898 29486400
Talipes 17.82 10.88 24 86205 1768 29486530
Cellulitis 17.76 10.88 71 86158 45769 29442529
Bronchitis 17.75 10.88 52 86177 36816 29451482
Central nervous system lesion 17.73 10.88 46 86183 5602 29482696
Orthostatic hypotension 17.72 10.88 24 86205 22605 29465693
Stress 17.64 10.88 22 86207 21468 29466830
Language disorder 17.62 10.88 25 86204 1934 29486364
Retinogram abnormal 17.58 10.88 8 86221 109 29488189
Metastatic malignant melanoma 17.58 10.88 24 86205 1791 29486507
Potter's syndrome 17.57 10.88 5 86224 14 29488284
Chemotherapeutic drug level above therapeutic 17.57 10.88 5 86224 14 29488284
Encephalitis viral 17.56 10.88 19 86210 1113 29487185
Intracranial tumour haemorrhage 17.56 10.88 11 86218 294 29488004
Cytotoxic oedema 17.54 10.88 9 86220 162 29488136
Coronary artery occlusion 17.45 10.88 4 86225 10090 29478208
Cleft palate 17.20 10.88 14 86215 570 29487728
Temporal lobe epilepsy 17.20 10.88 9 86220 169 29488129
Toxic skin eruption 17.17 10.88 65 86164 9692 29478606
Psychomotor retardation 17.15 10.88 31 86198 2945 29485353
Myocardial ischaemia 17.11 10.88 13 86216 16015 29472283
Product administered to patient of inappropriate age 17.05 10.88 29 86200 2626 29485672
Systemic inflammatory response syndrome 17.04 10.88 47 86182 5934 29482364
Flushing 16.97 10.88 37 86192 28955 29459343
Nasal congestion 16.93 10.88 18 86211 18861 29469437
Gastric ulcer 16.89 10.88 10 86219 14051 29474247
Dysphemia 16.89 10.88 21 86208 1429 29486869
Diverticulitis 16.89 10.88 16 86213 17688 29470610
Bladder hypertrophy 16.81 10.88 14 86215 589 29487709
Anaphylactic shock 16.72 10.88 9 86220 13327 29474971
Congenital anomaly 16.71 10.88 20 86209 1308 29486990
Hepatic cytolysis 16.71 10.88 58 86171 8289 29480009
Guillain-Barre syndrome 16.71 10.88 42 86187 5016 29483282
Injection site erythema 16.66 10.88 10 86219 13946 29474352
Gastrointestinal malformation 16.57 10.88 6 86223 43 29488255
Amnesia 16.56 10.88 118 86111 22525 29465773
Physical assault 16.48 10.88 18 86211 1066 29487232
Constipation 16.45 10.88 234 85995 113926 29374372
Sepsis 16.41 10.88 305 85924 142377 29345921
Meningeal disorder 16.38 10.88 11 86218 332 29487966
Localised infection 16.36 10.88 10 86219 13806 29474492
Syncope 16.31 10.88 155 86074 81216 29407082
Renal impairment 16.27 10.88 155 86074 81178 29407120
Herpes zoster 16.27 10.88 40 86189 30012 29458286
Pulmonary valve stenosis congenital 16.27 10.88 8 86221 131 29488167
Subacute sclerosing panencephalitis 16.21 10.88 5 86224 20 29488278
Brain tumour operation 16.13 10.88 4 86225 5 29488293
Paternal exposure before pregnancy 16.11 10.88 6 86223 47 29488251
Retinitis viral 16.10 10.88 7 86222 85 29488213
Use of accessory respiratory muscles 16.06 10.88 11 86218 343 29487955
Patent ductus arteriosus 16.03 10.88 31 86198 3100 29485198
Abdominal distension 16.02 10.88 74 86155 45837 29442461
Stomatitis 16.01 10.88 55 86174 37058 29451240
Epistaxis 15.95 10.88 87 86142 51617 29436681
CSF white blood cell count increased 15.89 10.88 6 86223 49 29488249
Renal injury 15.83 10.88 5 86224 10197 29478101
Subdural haematoma 15.83 10.88 99 86130 18094 29470204
Haematochezia 15.82 10.88 55 86174 36928 29451370
Caudal regression syndrome 15.79 10.88 6 86223 50 29488248
Superinfection 15.78 10.88 24 86205 1977 29486321
Rectal haemorrhage 15.73 10.88 50 86179 34499 29453799
Burning sensation 15.68 10.88 14 86215 15924 29472374
Therapeutic response unexpected 15.57 10.88 58 86171 8580 29479718
Brain neoplasm malignant 15.50 10.88 13 86216 552 29487746
Diabetes mellitus inadequate control 15.49 10.88 8 86221 12126 29476172
Gastric haemorrhage 15.46 10.88 4 86225 9293 29479005
Barbiturates positive 15.34 10.88 4 86225 7 29488291
Product taste abnormal 15.25 10.88 17 86212 1030 29487268
MELAS syndrome 15.16 10.88 5 86224 26 29488272
Drug eruption 15.14 10.88 92 86137 16649 29471649
Agitation neonatal 15.13 10.88 17 86212 1039 29487259
Arteriosclerosis coronary artery 15.09 10.88 6 86223 10599 29477699
Cerebellar atrophy 15.01 10.88 12 86217 476 29487822
Gastritis 14.98 10.88 21 86208 19496 29468802
Conjunctival irritation 14.96 10.88 7 86222 102 29488196
Myelodysplastic syndrome 14.83 10.88 18 86211 17776 29470522
Feeling hot 14.77 10.88 14 86215 15474 29472824
Astrocytoma 14.75 10.88 8 86221 162 29488136
Hot flush 14.70 10.88 13 86216 14857 29473441
Foetal cardiac disorder 14.67 10.88 4 86225 9 29488289
Movement disorder 14.67 10.88 64 86165 10173 29478125
Perseveration 14.66 10.88 7 86222 107 29488191
Neonatal respiratory depression 14.56 10.88 11 86218 401 29487897
Prominent epicanthal folds 14.53 10.88 8 86221 167 29488131
Upper airway obstruction 14.53 10.88 13 86216 603 29487695
Infant sedation 14.52 10.88 3 86226 0 29488298
Brain lobectomy 14.52 10.88 3 86226 0 29488298
Bronchopulmonary aspergillosis 14.52 10.88 9 86220 12335 29475963
Crystalluria 14.49 10.88 11 86218 404 29487894
Hypotension 14.44 10.88 444 85785 193910 29294388
Haemorrhoids 14.42 10.88 8 86221 11649 29476649
Bronchospasm 14.40 10.88 5 86224 9604 29478694
Osteonecrosis 14.38 10.88 11 86218 13508 29474790
Deja vu 14.38 10.88 4 86225 10 29488288
Anaplastic astrocytoma 14.38 10.88 7 86222 112 29488186
Myositis 14.33 10.88 6 86223 10277 29478021
Apathy 14.25 10.88 45 86184 6126 29482172
Hyperacusis 14.18 10.88 14 86215 736 29487562
Blood pressure systolic increased 14.08 10.88 17 86212 16828 29471470
Creutzfeldt-Jakob disease 14.03 10.88 5 86224 34 29488264
Drug monitoring procedure not performed 14.03 10.88 9 86220 251 29488047
Drug abuse 14.02 10.88 157 86072 79726 29408572
Low set ears 13.99 10.88 11 86218 426 29487872
Bradykinesia 13.97 10.88 31 86198 3416 29484882
Glycosylated haemoglobin increased 13.97 10.88 5 86224 9421 29478877
Oligodendroglioma 13.91 10.88 5 86224 35 29488263
Noninfective encephalitis 13.91 10.88 5 86224 35 29488263
Monorchidism 13.85 10.88 4 86225 12 29488286
Drug dependence 13.81 10.88 25 86204 20956 29467342
Oedema 13.68 10.88 66 86163 40417 29447881
Drug-induced liver injury 13.67 10.88 109 86120 21546 29466752
Upper gastrointestinal haemorrhage 13.64 10.88 27 86202 21887 29466411
Niemann-Pick disease 13.61 10.88 4 86225 13 29488285
Penoscrotal fusion 13.61 10.88 4 86225 13 29488285
Amnestic disorder 13.61 10.88 8 86221 190 29488108
Large granular lymphocytosis 13.61 10.88 8 86221 190 29488108
Gross motor delay 13.60 10.88 9 86220 265 29488033
Congenital megaureter 13.54 10.88 7 86222 128 29488170
Oropharyngeal swelling 13.39 10.88 11 86218 454 29487844
Tonic clonic movements 13.30 10.88 15 86214 920 29487378
Musculoskeletal stiffness 13.29 10.88 60 86169 37398 29450900
Blood urea increased 13.28 10.88 40 86189 28072 29460226
Type 2 diabetes mellitus 13.28 10.88 12 86217 13569 29474729
Hyperpyrexia 13.23 10.88 24 86205 2286 29486012
Tricuspid valve incompetence 13.23 10.88 4 86225 8390 29479908
Asthenospermia 13.23 10.88 5 86224 41 29488257
Infusion site induration 13.17 10.88 8 86221 202 29488096
Dysarthria 13.16 10.88 143 86086 30768 29457530
Thrombocytopenia neonatal 13.13 10.88 10 86219 369 29487929
Blood ketone body increased 13.06 10.88 10 86219 372 29487926
Lower respiratory tract infection 13.03 10.88 37 86192 26465 29461833
Acute hepatic failure 12.99 10.88 69 86160 11883 29476415
Lethargy 12.97 10.88 167 86062 37413 29450885
Craniofacial deformity 12.91 10.88 6 86223 86 29488212
Oropharyngeal pain 12.90 10.88 43 86186 29242 29459056
Glioma 12.83 10.88 9 86220 292 29488006
Red blood cell sedimentation rate increased 12.81 10.88 3 86226 7458 29480840
Skin ulcer 12.81 10.88 22 86207 18818 29469480
Contusion 12.80 10.88 47 86182 31048 29457250
Squamous cell carcinoma 12.73 10.88 7 86222 10244 29478054
Aspartate aminotransferase increased 12.73 10.88 112 86117 59613 29428685
Blood pressure decreased 12.70 10.88 79 86150 45398 29442900
Limb discomfort 12.68 10.88 6 86223 9562 29478736
Intestinal obstruction 12.66 10.88 23 86206 19254 29469044
Presyncope 12.66 10.88 17 86212 16072 29472226
Epileptic psychosis 12.60 10.88 4 86225 18 29488280
Cholelithiasis 12.51 10.88 22 86207 18650 29469648
Intellectual disability 12.50 10.88 16 86213 1121 29487177
Head injury 12.46 10.88 85 86144 15996 29472302
Ejection fraction decreased 12.45 10.88 17 86212 15961 29472337
Near drowning 12.45 10.88 3 86226 3 29488295
Urinary tract malformation 12.45 10.88 3 86226 3 29488295
Ganglioglioma 12.45 10.88 3 86226 3 29488295
Post-anoxic myoclonus 12.45 10.88 3 86226 3 29488295
Executive dysfunction 12.44 10.88 8 86221 224 29488074
Transient aphasia 12.44 10.88 6 86223 94 29488204
Appendicitis 12.43 10.88 5 86224 8774 29479524
Hypothalamo-pituitary disorder 12.38 10.88 13 86216 736 29487562
Unevaluable event 12.36 10.88 45 86184 29806 29458492
Athetosis 12.36 10.88 5 86224 50 29488248
Crying 12.34 10.88 39 86190 5312 29482986
Hallucination 12.34 10.88 191 86038 44521 29443777
Injection site swelling 12.33 10.88 6 86223 9411 29478887
Congenital genital malformation 12.32 10.88 6 86223 96 29488202
Urticaria 12.32 10.88 101 86128 54559 29433739
Arthropod sting 12.31 10.88 9 86220 312 29487986
Cardiomyopathy 12.28 10.88 15 86214 14772 29473526
Prescribed overdose 12.23 10.88 54 86175 8629 29479669
Foetal anticonvulsant syndrome 12.21 10.88 16 86213 1148 29487150
Haematuria 12.16 10.88 77 86152 44062 29444236
Posture abnormal 12.15 10.88 21 86208 1926 29486372
Intestinal ischaemia 12.12 10.88 45 86184 6647 29481651
Ischaemic stroke 12.12 10.88 84 86145 15893 29472405
Fall 12.10 10.88 632 85597 176546 29311752
Impaired healing 12.08 10.88 13 86216 13545 29474753
Gastrointestinal disorder 12.07 10.88 43 86186 28663 29459635
Haemorrhage intracranial 11.95 10.88 78 86151 14464 29473834
Coronary artery stenosis 11.95 10.88 5 86224 8568 29479730
Salivary hypersecretion 11.93 10.88 48 86181 7361 29480937
Coma 11.85 10.88 171 86058 39279 29449019
Neurodevelopmental disorder 11.85 10.88 9 86220 331 29487967
Apraxia 11.84 10.88 16 86213 1182 29487116
Feeling cold 11.82 10.88 6 86223 9185 29479113
Hypersensitivity 11.81 10.88 98 86131 52805 29435493
Device malfunction 11.80 10.88 5 86224 8502 29479796
Accidental exposure to product by child 11.77 10.88 17 86212 1337 29486961
Product use issue 11.72 10.88 213 86016 51231 29437067
Contraindicated product prescribed 11.66 10.88 9 86220 339 29487959
Infant irritability 11.65 10.88 4 86225 24 29488274
Periventricular haemorrhage neonatal 11.65 10.88 4 86225 24 29488274
Diabetic ketoacidosis 11.65 10.88 18 86211 16055 29472243
Restless legs syndrome 11.62 10.88 3 86226 6981 29481317
Intentional self-injury 11.60 10.88 69 86160 12392 29475906
Fatigue 11.60 10.88 782 85447 316039 29172259
Paresis 11.57 10.88 20 86209 1834 29486464
Clonus 11.52 10.88 23 86206 2355 29485943
Pruritus allergic 11.48 10.88 7 86222 178 29488120
Cerebral haemorrhage neonatal 11.45 10.88 8 86221 258 29488040
Tremor 11.42 10.88 288 85941 73250 29415048
Gallbladder polyp 11.39 10.88 9 86220 351 29487947
Hyperuricaemia 11.38 10.88 3 86226 6886 29481412
School refusal 11.38 10.88 4 86225 26 29488272
Heart rate decreased 11.37 10.88 36 86193 24876 29463422
Graft versus host disease 11.35 10.88 7 86222 9621 29478677
Accidental overdose 11.35 10.88 89 86140 17504 29470794
Haematuria traumatic 11.34 10.88 7 86222 182 29488116
C-reactive protein increased 11.30 10.88 79 86150 44184 29444114
Onychophagia 11.27 10.88 5 86224 64 29488234
Congenital hydronephrosis 11.26 10.88 12 86217 691 29487607
Assisted delivery 11.24 10.88 3 86226 6 29488292
Verbigeration 11.24 10.88 3 86226 6 29488292
Transient epileptic amnesia 11.24 10.88 3 86226 6 29488292
Cataract subcapsular 11.24 10.88 9 86220 358 29487940
Pneumothorax 11.23 10.88 18 86211 15824 29472474
Proteinuria 11.16 10.88 18 86211 15786 29472512
Neurological symptom 11.15 10.88 28 86201 3342 29484956
Tooth disorder 11.14 10.88 7 86222 9522 29478776
CSF white blood cell count decreased 11.13 10.88 4 86225 28 29488270
Retrognathia 11.02 10.88 8 86221 274 29488024
Drug level increased 11.01 10.88 93 86136 18694 29469604
Dyscalculia 11.01 10.88 4 86225 29 29488269
Congenital nose malformation 10.92 10.88 7 86222 195 29488103
Thought blocking 10.91 10.88 6 86223 125 29488173
Foetal distress syndrome 10.89 10.88 14 86215 985 29487313
Product lot number issue 10.89 10.88 4 86225 30 29488268

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Seizure 6218.90 9.96 4209 147432 162683 64184408
Status epilepticus 3000.15 9.96 1310 150331 20353 64326738
Generalised tonic-clonic seizure 1666.85 9.96 1084 150557 38773 64308318
Epilepsy 1493.51 9.96 949 150692 32582 64314509
Multiple-drug resistance 980.78 9.96 418 151223 6084 64341007
Aggression 905.13 9.96 799 150842 45433 64301658
Partial seizures 895.71 9.96 406 151235 6901 64340190
Psychogenic seizure 636.97 9.96 217 151424 1624 64345467
Drug reaction with eosinophilia and systemic symptoms 600.42 9.96 688 150953 53529 64293562
Somnolence 488.62 9.96 1309 150332 202336 64144755
Product substitution issue 464.45 9.96 364 151277 17497 64329594
Drug ineffective 455.79 9.96 3449 148192 836798 63510293
Petit mal epilepsy 443.81 9.96 223 151418 4809 64342282
Arthralgia 424.21 9.96 258 151383 442002 63905089
Focal dyscognitive seizures 416.50 9.96 187 151454 3103 64343988
Irritability 404.53 9.96 465 151176 36281 64310810
Dyspnoea 393.20 9.96 681 150960 717993 63629098
Cytokine release syndrome 391.56 9.96 352 151289 20477 64326614
Rhabdomyolysis 348.91 9.96 707 150934 91019 64256072
Rheumatoid arthritis 333.07 9.96 12 151629 164282 64182809
Pain 319.47 9.96 506 151135 553005 63794086
Anticonvulsant drug level decreased 317.44 9.96 130 151511 1700 64345391
Agitation 314.79 9.96 663 150978 87704 64259387
Encephalopathy 299.58 9.96 514 151127 58305 64288786
Paradoxical drug reaction 296.86 9.96 183 151458 5937 64341154
Drug interaction 289.37 9.96 1641 150000 360442 63986649
Hyperammonaemia 286.31 9.96 215 151426 9689 64337402
Abnormal behaviour 285.05 9.96 373 151268 33249 64313842
Pregnancy 283.49 9.96 295 151346 20570 64326521
Joint swelling 275.69 9.96 82 151559 215300 64131791
Drug withdrawal convulsions 266.34 9.96 120 151521 2008 64345083
Psychotic disorder 264.72 9.96 365 151276 34213 64312878
Ataxia 262.68 9.96 291 151350 21793 64325298
Aphasia 255.27 9.96 392 151249 40514 64306577
Myoclonus 253.38 9.96 304 151337 24814 64322277
Myoclonic epilepsy 251.17 9.96 106 151535 1502 64345589
Behaviour disorder 246.36 9.96 145 151496 4317 64342774
Sudden unexplained death in epilepsy 241.26 9.96 80 151561 545 64346546
Cognitive disorder 239.07 9.96 449 151192 54638 64292453
Thrombocytopenia 235.49 9.96 1096 150545 222705 64124386
Arthropathy 219.75 9.96 17 151624 120950 64226141
Hyperammonaemic encephalopathy 219.15 9.96 130 151511 3928 64343163
Synovitis 208.93 9.96 5 151636 99085 64248006
Anticonvulsant drug level increased 208.61 9.96 105 151536 2272 64344819
Diarrhoea 201.01 9.96 946 150695 721758 63625333
Abdominal discomfort 200.12 9.96 89 151552 182233 64164858
Drug ineffective for unapproved indication 199.39 9.96 302 151339 30831 64316260
Aura 190.85 9.96 73 151568 787 64346304
Electroencephalogram abnormal 187.16 9.96 129 151512 5074 64342017
Pain in extremity 187.11 9.96 264 151377 302821 64044270
No adverse event 181.42 9.96 276 151365 28285 64318806
Drug resistance 179.01 9.96 307 151334 34795 64312296
Hepatocellular injury 175.86 9.96 352 151289 44883 64302208
Infusion related reaction 174.73 9.96 84 151557 164383 64182708
Exposure during pregnancy 174.59 9.96 488 151153 77187 64269904
Nausea 172.25 9.96 1113 150528 784687 63562404
Sinusitis 171.88 9.96 64 151577 145864 64201227
Seizure cluster 170.68 9.96 54 151587 310 64346781
Myocardial infarction 166.75 9.96 91 151550 165730 64181361
Infantile spasms 166.65 9.96 50 151591 233 64346858
Foetal exposure during pregnancy 163.43 9.96 112 151529 4364 64342727
Abortion spontaneous 162.57 9.96 245 151396 24898 64322193
Contraindicated product administered 159.65 9.96 30 151611 107799 64239292
Confusional state 157.95 9.96 1103 150538 260041 64087050
Peripheral swelling 151.33 9.96 161 151480 208992 64138099
Partial seizures with secondary generalisation 150.88 9.96 53 151588 439 64346652
Anticonvulsant drug level above therapeutic 148.00 9.96 64 151577 966 64346125
Stevens-Johnson syndrome 144.65 9.96 276 151365 33973 64313118
Hemiparesis 136.76 9.96 249 151392 29578 64317513
Malaise 133.98 9.96 480 151161 395767 63951324
Immune effector cell-associated neurotoxicity syndrome 132.01 9.96 80 151561 2515 64344576
Swelling 131.52 9.96 110 151531 160108 64186983
Back pain 129.88 9.96 244 151397 249927 64097164
Nasopharyngitis 129.86 9.96 162 151479 195911 64151180
Glioblastoma 129.57 9.96 65 151576 1396 64345695
Cardiac failure congestive 129.33 9.96 73 151568 130507 64216584
Neurotoxicity 128.48 9.96 231 151410 27173 64319918
Off label use 128.24 9.96 2143 149498 630663 63716428
Brain oedema 127.21 9.96 204 151437 21871 64325220
Tonic convulsion 125.01 9.96 69 151572 1812 64345279
Anger 121.71 9.96 167 151474 15574 64331517
Disturbance in attention 121.21 9.96 286 151355 40788 64306303
Postictal psychosis 120.37 9.96 34 151607 122 64346969
Pemphigus 117.76 9.96 6 151635 60695 64286396
Low birth weight baby 115.40 9.96 45 151596 513 64346578
Injection site pain 115.12 9.96 59 151582 111349 64235742
Drug hypersensitivity 114.80 9.96 242 151399 237573 64109518
Overdose 114.64 9.96 704 150937 158862 64188229
Nystagmus 113.92 9.96 123 151518 8945 64338146
Anticonvulsant drug level below therapeutic 113.28 9.96 53 151588 971 64346120
Cholestasis 112.93 9.96 294 151347 44578 64302513
Hallucination, visual 112.27 9.96 220 151421 27614 64319477
Cough 111.64 9.96 352 151289 301796 64045295
Chest pain 111.52 9.96 243 151398 235737 64111354
Eosinophilia 110.05 9.96 263 151378 37813 64309278
Pneumonia aspiration 109.99 9.96 348 151293 58923 64288168
Glioblastoma multiforme 107.69 9.96 53 151588 1091 64346000
Propofol infusion syndrome 106.60 9.96 59 151582 1558 64345533
Leukopenia 106.41 9.96 496 151145 100746 64246345
Drug level decreased 105.93 9.96 133 151508 11370 64335721
Substance-induced psychotic disorder 105.49 9.96 71 151570 2684 64344407
Arthritis 105.17 9.96 33 151608 83781 64263310
Acute generalised exanthematous pustulosis 103.98 9.96 146 151495 13912 64333179
Suicidal ideation 101.66 9.96 366 151275 66176 64280915
Glossodynia 100.13 9.96 16 151625 64680 64282411
Hallucination, auditory 99.61 9.96 158 151483 16781 64330310
Mood altered 99.47 9.96 153 151488 15826 64331265
Delusion 99.08 9.96 163 151478 17851 64329240
Encephalitis autoimmune 98.21 9.96 59 151582 1825 64345266
Disorientation 97.44 9.96 321 151320 55507 64291584
Product administration error 95.55 9.96 205 151436 27438 64319653
Toxic epidermal necrolysis 95.06 9.96 245 151396 36921 64310170
Exposure via breast milk 93.76 9.96 43 151598 751 64346340
Pericarditis 93.37 9.96 17 151624 62499 64284592
Chest discomfort 92.48 9.96 82 151559 116024 64231067
Psychomotor hyperactivity 92.25 9.96 140 151501 14311 64332780
Drug level increased 92.22 9.96 230 151411 33966 64313125
Hypersensitivity 90.57 9.96 205 151436 196247 64150844
Discomfort 89.44 9.96 39 151602 80839 64266252
Mental status changes 88.87 9.96 331 151310 60831 64286260
Therapeutic product effect decreased 88.86 9.96 84 151557 115267 64231824
Brain neoplasm 88.83 9.96 81 151560 4797 64342294
Atonic seizures 88.02 9.96 39 151602 626 64346465
Delirium 87.97 9.96 359 151282 68835 64278256
Lower respiratory tract infection 87.92 9.96 57 151584 94557 64252534
Simple partial seizures 87.68 9.96 39 151602 632 64346459
Persecutory delusion 87.61 9.96 75 151566 4083 64343008
Blood pressure increased 86.27 9.96 172 151469 172380 64174711
Injection site erythema 85.11 9.96 30 151611 70770 64276321
Asthma 84.96 9.96 60 151581 95165 64251926
Alopecia 84.71 9.96 163 151478 165527 64181564
Pancytopenia 83.97 9.96 601 151040 142708 64204383
Cerebellar ataxia 83.14 9.96 52 151589 1731 64345360
Impaired healing 83.00 9.96 20 151621 60453 64286638
Agranulocytosis 82.75 9.96 237 151404 37992 64309099
Paranoia 82.02 9.96 142 151499 16210 64330881
Aplastic anaemia 80.70 9.96 129 151512 13791 64333300
Pruritus 80.63 9.96 419 151222 311981 64035110
Musculoskeletal stiffness 80.28 9.96 103 151538 123103 64223988
Coronary artery disease 79.09 9.96 22 151619 60411 64286680
Change in seizure presentation 78.83 9.96 29 151612 278 64346813
Altered state of consciousness 77.26 9.96 230 151411 37672 64309419
Cerebral haemorrhage 77.17 9.96 280 151361 50810 64296281
Helicobacter infection 77.01 9.96 3 151638 38359 64308732
Haemophagocytic lymphohistiocytosis 76.94 9.96 144 151497 17465 64329626
Posterior reversible encephalopathy syndrome 76.83 9.96 168 151473 22778 64324313
Oedema peripheral 76.23 9.96 247 151394 210070 64137021
Memory impairment 75.96 9.96 400 151241 85282 64261809
Osteoarthritis 75.85 9.96 27 151614 63309 64283782
Hyponatraemia 75.05 9.96 601 151040 147738 64199353
Abdominal pain upper 74.84 9.96 190 151451 174840 64172251
Affect lability 73.49 9.96 98 151543 8892 64338199
Blood creatine phosphokinase increased 73.00 9.96 302 151339 58256 64288835
Rash maculo-papular 72.96 9.96 260 151381 46766 64300325
Premature delivery 72.64 9.96 145 151496 18444 64328647
Psoriasis 72.54 9.96 39 151602 71664 64275427
Thinking abnormal 72.42 9.96 111 151530 11445 64335646
Bronchitis 71.79 9.96 90 151551 108653 64238438
Psoriatic arthropathy 70.96 9.96 9 151632 43272 64303819
Abdominal pain 70.84 9.96 437 151204 311938 64035153
Central nervous system lesion 70.33 9.96 111 151530 11738 64335353
Myalgia 70.30 9.96 169 151472 158448 64188643
Drug intolerance 70.07 9.96 218 151423 187774 64159317
Toxic encephalopathy 69.73 9.96 100 151541 9715 64337376
Duodenal ulcer perforation 68.52 9.96 3 151638 34622 64312469
Personality change 67.69 9.96 92 151549 8501 64338590
Affective disorder 66.93 9.96 80 151561 6500 64340591
Maternal exposure during pregnancy 66.28 9.96 419 151222 95465 64251626
Neurological decompensation 66.21 9.96 66 151575 4370 64342721
Caesarean section 66.07 9.96 105 151536 11169 64335922
Irritable bowel syndrome 65.78 9.96 6 151635 37363 64309728
Irregular sleep phase 64.97 9.96 18 151623 59 64347032
Gastrointestinal haemorrhage 64.32 9.96 134 151507 132178 64214913
Nasal congestion 64.03 9.96 30 151611 59628 64287463
Obsessive-compulsive disorder 63.43 9.96 67 151574 4751 64342340
Neuropsychiatric symptoms 63.00 9.96 35 151606 931 64346160
Respiratory disorder neonatal 62.74 9.96 17 151624 50 64347041
Suicidal behaviour 62.72 9.96 53 151588 2834 64344257
Necrosis ischaemic 62.43 9.96 35 151606 948 64346143
Acute myocardial infarction 62.09 9.96 44 151597 69674 64277417
Acidosis hyperchloraemic 62.00 9.96 31 151610 661 64346430
Hypothermia 61.57 9.96 141 151500 19715 64327376
Muscle twitching 61.24 9.96 137 151504 18861 64328230
Stupor 60.78 9.96 73 151568 5962 64341129
Idiopathic generalised epilepsy 60.65 9.96 16 151625 41 64347050
Febrile convulsion 60.01 9.96 32 151609 783 64346308
Dyspnoea exertional 60.00 9.96 51 151590 73679 64273412
Gaze palsy 59.94 9.96 49 151592 2501 64344590
Hallucination 59.90 9.96 333 151308 72455 64274636
Bradyphrenia 59.86 9.96 91 151550 9315 64337776
Maternal exposure before pregnancy 59.86 9.96 56 151585 3427 64343664
Flushing 59.71 9.96 58 151583 78590 64268501
Excessive eye blinking 59.39 9.96 37 151604 1223 64345868
Injection site pruritus 59.34 9.96 9 151632 37817 64309274
Small for dates baby 58.92 9.96 26 151615 413 64346678
Depressed level of consciousness 58.87 9.96 360 151281 81076 64266015
Fatigue 58.68 9.96 1328 150313 747402 63599689
Productive cough 56.73 9.96 53 151588 73150 64273941
Speech disorder 56.63 9.96 245 151396 48196 64298895
Lymphopenia 56.43 9.96 160 151481 25497 64321594
Coma 56.35 9.96 376 151265 87239 64259852
Epileptic aura 56.10 9.96 16 151625 60 64347031
Hypertension 56.03 9.96 368 151273 258893 64088198
Breast feeding 55.97 9.96 29 151612 668 64346423
Mitochondrial DNA mutation 53.96 9.96 21 151620 238 64346853
Dysarthria 53.79 9.96 279 151362 59127 64287964
Condition aggravated 53.52 9.96 1198 150443 371228 63975863
Tubulointerstitial nephritis 53.28 9.96 177 151464 30732 64316359
Acute psychosis 52.67 9.96 54 151587 3698 64343393
Fluid retention 52.58 9.96 38 151603 59568 64287523
Red blood cell sedimentation rate increased 52.42 9.96 6 151635 31229 64315862
Injection site swelling 52.38 9.96 16 151625 41337 64305754
Coma blister 52.25 9.96 20 151621 216 64346875
Hypotonia 51.89 9.96 94 151547 11118 64335973
Herpes zoster 51.78 9.96 66 151575 79121 64267970
Gastrooesophageal reflux disease 51.61 9.96 72 151569 83071 64264020
Systemic lupus erythematosus 51.46 9.96 64 151577 77548 64269543
Encephalitis 51.46 9.96 100 151541 12471 64334620
Intellectual disability 51.02 9.96 31 151610 979 64346112
Ammonia increased 50.91 9.96 72 151569 6905 64340186
Fibromyalgia 50.66 9.96 11 151630 35720 64311371
Toxic skin eruption 49.18 9.96 127 151514 19157 64327934
Intensive care unit acquired weakness 48.82 9.96 37 151604 1690 64345401
Sopor 48.61 9.96 167 151474 29494 64317597
Organic brain syndrome 48.49 9.96 23 151618 435 64346656
Suicide attempt 48.26 9.96 309 151332 70698 64276393
Intra-abdominal pressure increased 47.85 9.96 19 151622 228 64346863
Autism spectrum disorder 47.84 9.96 29 151612 912 64346179
Osteonecrosis of jaw 47.65 9.96 17 151624 39808 64307283
Blood pressure fluctuation 47.17 9.96 32 151609 51839 64295252
Treatment noncompliance 47.11 9.96 215 151426 43267 64303824
Apathy 46.78 9.96 90 151551 11142 64335949
Feeling hot 45.95 9.96 25 151616 45638 64301453
Accidental death 45.87 9.96 50 151591 3675 64343416
Blood pressure systolic increased 45.65 9.96 30 151611 49423 64297668
Night sweats 45.56 9.96 14 151627 36032 64311059
Intentional self-injury 45.41 9.96 161 151480 28883 64318208
Haemoglobin decreased 45.16 9.96 271 151370 194792 64152299
Muscle spasms 44.81 9.96 175 151466 140848 64206243
Eye movement disorder 44.36 9.96 68 151573 7011 64340080
Inappropriate antidiuretic hormone secretion 44.23 9.96 134 151507 22155 64324936
Pleural effusion 44.20 9.96 151 151490 126408 64220683
Wheezing 44.07 9.96 76 151565 80503 64266588
Intracranial tumour haemorrhage 43.81 9.96 21 151620 407 64346684
Influenza 43.71 9.96 118 151523 106413 64240678
Hydrocephalus 43.52 9.96 70 151571 7521 64339570
Injection site reaction 43.49 9.96 28 151613 46636 64300455
Autonomic nervous system imbalance 43.29 9.96 51 151590 4081 64343010
Psychiatric symptom 43.23 9.96 63 151578 6210 64340881
Developmental delay 42.79 9.96 28 151613 1009 64346082
Pulmonary fibrosis 42.77 9.96 9 151632 29869 64317222
Depressed mood 42.37 9.96 200 151441 40812 64306279
Abortion induced 42.36 9.96 63 151578 6325 64340766
Glomerulonephritis minimal lesion 42.19 9.96 24 151617 669 64346422
Gastrointestinal disorder 41.81 9.96 93 151548 89616 64257475
Learning disorder 41.79 9.96 22 151619 524 64346567
Anaemia 41.61 9.96 633 151008 378047 63969044
Mood swings 41.45 9.96 112 151529 17356 64329735
Accidental poisoning 40.79 9.96 31 151610 1422 64345669
Balance disorder 40.77 9.96 337 151304 83589 64263502
Chronic obstructive pulmonary disease 40.72 9.96 65 151576 70983 64276108
Brain operation 40.16 9.96 22 151619 569 64346522
Retinogram abnormal 40.01 9.96 18 151623 300 64346791
Developmental regression 39.95 9.96 11 151630 35 64347056
Cataract 39.85 9.96 37 151604 51225 64295866
Coordination abnormal 39.66 9.96 100 151541 14864 64332227
Stomatitis 39.48 9.96 129 151512 109476 64237615
Hypertransaminasaemia 39.45 9.96 65 151576 7126 64339965
Atrial fibrillation 39.43 9.96 238 151403 170851 64176240
Angina pectoris 39.42 9.96 29 151612 45052 64302039
Knee arthroplasty 38.92 9.96 8 151633 26991 64320100
Urticaria 38.84 9.96 196 151445 147121 64199970
Hyperkalaemia 38.56 9.96 116 151525 101013 64246078
Pneumatosis 38.56 9.96 24 151617 792 64346299
Inflammation 38.13 9.96 59 151582 65241 64281850
Staring 38.10 9.96 37 151604 2373 64344718
Foetal growth restriction 38.08 9.96 32 151609 1698 64345393
Acute hepatic failure 37.65 9.96 141 151500 25971 64321120
Deja vu 37.62 9.96 11 151630 46 64347045
Skin ulcer 37.54 9.96 29 151612 43945 64303146
Mental disorder 37.47 9.96 142 151499 26303 64320788
Diplopia 37.33 9.96 143 151498 26622 64320469
Infection 37.16 9.96 268 151373 184612 64162479
Palpitations 36.93 9.96 124 151517 104364 64242727
Transaminases increased 36.67 9.96 204 151437 44390 64302701
Amnesia 36.54 9.96 216 151425 48053 64299038
Chills 36.54 9.96 182 151459 137082 64210009
Diabetes insipidus 36.52 9.96 49 151592 4472 64342619
Granuloma annulare 36.48 9.96 20 151621 518 64346573
Convulsive threshold lowered 36.43 9.96 24 151617 875 64346216
Cardiac failure 36.11 9.96 174 151467 132199 64214892
Hip arthroplasty 36.09 9.96 4 151637 21347 64325744
Subdural haematoma 35.99 9.96 146 151495 27908 64319183
Neuropathy peripheral 35.97 9.96 148 151493 117377 64229714
JC polyomavirus test 35.59 9.96 10 151631 35 64347056
Mutism 35.53 9.96 33 151608 2001 64345090
Cellulitis 35.30 9.96 108 151533 93549 64253542
Oropharyngeal pain 35.29 9.96 100 151541 88767 64258324
Depressive symptom 35.21 9.96 48 151593 4448 64342643
Postictal state 35.20 9.96 30 151611 1623 64345468
Respiratory acidosis 35.11 9.96 74 151567 9781 64337310
Feeling abnormal 35.07 9.96 178 151463 133424 64213667
Stillbirth 35.05 9.96 43 151598 3590 64343501
Injection site bruising 35.04 9.96 21 151620 36352 64310739
Asterixis 34.98 9.96 35 151606 2328 64344763
Congenital cyst 34.92 9.96 8 151633 8 64347083
Terminal insomnia 34.90 9.96 24 151617 940 64346151
Restlessness 34.73 9.96 185 151456 39600 64307491
Psychomotor skills impaired 34.68 9.96 44 151597 3801 64343290
Toxicity to various agents 34.52 9.96 1108 150533 362405 63984686
Osteoporosis 34.36 9.96 29 151612 42051 64305040
Maternal exposure during breast feeding 33.85 9.96 32 151609 1984 64345107
Asthenia 33.74 9.96 758 150883 427286 63919805
Hyperhidrosis 33.61 9.96 165 151476 124755 64222336
Drug eruption 33.60 9.96 171 151470 35965 64311126
MELAS syndrome 33.59 9.96 13 151628 145 64346946
Therapeutic response unexpected 33.54 9.96 102 151539 16899 64330192
Hypomagnesaemia 33.45 9.96 175 151466 37201 64309890
Hepatitis 33.24 9.96 202 151439 45380 64301711
Pulmonary oedema 33.14 9.96 86 151555 78588 64268503
Bradycardia 33.08 9.96 424 151217 117795 64229296
Joint stiffness 33.07 9.96 15 151626 30389 64316702
Educational problem 32.99 9.96 17 151624 387 64346704
Haemoptysis 32.98 9.96 40 151601 49008 64298083
Hot flush 32.94 9.96 36 151605 46199 64300892
Dyskinesia 32.93 9.96 181 151460 39207 64307884
Brain malformation 32.92 9.96 10 151631 49 64347042
Burning sensation 32.87 9.96 41 151600 49623 64297468
Cross sensitivity reaction 32.72 9.96 40 151601 3327 64343764
Postictal paralysis 32.44 9.96 16 151625 331 64346760
Diverticulitis 32.30 9.96 26 151615 38592 64308499
Angiofibroma 32.08 9.96 12 151629 121 64346970
Premature baby 32.00 9.96 39 151602 3233 64343858
Musculoskeletal pain 31.89 9.96 92 151549 81202 64265889
Hypernatraemia 31.83 9.96 81 151560 12108 64334983
Plasmapheresis 31.82 9.96 19 151622 581 64346510
Creutzfeldt-Jakob disease 31.81 9.96 13 151628 169 64346922
Pulmonary arterial hypertension 31.79 9.96 10 151631 25357 64321734
Acute coronary syndrome 31.69 9.96 4 151637 19306 64327785
Rash morbilliform 31.68 9.96 49 151592 5092 64341999
Blood glucose increased 31.60 9.96 121 151520 97952 64249139
Impulsive behaviour 31.50 9.96 35 151606 2628 64344463
Intestinal ischaemia 31.47 9.96 78 151563 11471 64335620
Anaphylactic shock 31.40 9.96 16 151625 30312 64316779
Blepharospasm 31.04 9.96 39 151602 3336 64343755
Systemic inflammatory response syndrome 30.98 9.96 72 151569 10163 64336928
Contusion 30.97 9.96 150 151491 113815 64233276
Febrile neutropenia 30.86 9.96 287 151354 187370 64159721
COVID-19 30.78 9.96 67 151574 65073 64282018
Metabolic encephalopathy 30.64 9.96 62 151579 7963 64339128
Rhinorrhoea 30.62 9.96 59 151582 59910 64287181
Plasma cell myeloma 30.54 9.96 38 151603 46037 64301054
Congenital megaureter 30.33 9.96 6 151635 0 64347091
Failure to suspend medication 30.10 9.96 16 151625 389 64346702
Wrong product administered 29.90 9.96 60 151581 7660 64339431
Bursitis 29.69 9.96 7 151634 21478 64325613
Blood creatinine increased 29.67 9.96 192 151449 135590 64211501
Brief psychotic disorder, with postpartum onset 29.66 9.96 8 151633 23 64347068
Haemorrhage intracranial 29.61 9.96 123 151518 23761 64323330
Clonic convulsion 29.50 9.96 23 151618 1096 64345995
Drop attacks 29.26 9.96 22 151619 993 64346098
Cardiac arrest neonatal 29.16 9.96 8 151633 25 64347066
Melaena 28.83 9.96 51 151590 53497 64293594
Mania 28.72 9.96 94 151547 16192 64330899
Porphyria acute 28.64 9.96 19 151622 701 64346390
Oedema 28.61 9.96 115 151526 91820 64255271
Cardiac disorder 28.42 9.96 55 151586 55761 64291330
Tremor 28.34 9.96 498 151143 147732 64199359
Malignant catatonia 28.32 9.96 15 151626 362 64346729
Wound 28.24 9.96 89 151552 76388 64270703
Meningioma 28.24 9.96 40 151601 3842 64343249
Cardiogenic shock 28.17 9.96 21 151620 32406 64314685
Apraxia 28.16 9.96 32 151609 2463 64344628
Eosinophilic cystitis 27.97 9.96 9 151632 55 64347036
Hostility 27.83 9.96 30 151611 2177 64344914
Tooth disorder 27.77 9.96 9 151632 22393 64324698
Diabetes mellitus 27.74 9.96 73 151568 66401 64280690
Oculogyric crisis 27.71 9.96 32 151609 2506 64344585
Osteonecrosis 27.62 9.96 16 151625 28213 64318878
Dry eye 27.61 9.96 17 151624 29002 64318089
Oropharyngeal oedema 27.60 9.96 13 151628 242 64346849
Altered pitch perception 27.41 9.96 7 151634 15 64347076
Limbic encephalitis 27.40 9.96 18 151623 653 64346438
Dyspepsia 27.24 9.96 97 151544 80215 64266876
Malabsorption 27.18 9.96 42 151599 4361 64342730
Retrograde amnesia 26.98 9.96 16 151625 483 64346608
Purple glove syndrome 26.89 9.96 13 151628 257 64346834
Electrocardiogram QRS complex prolonged 26.86 9.96 64 151577 9180 64337911
Cerebral haemorrhage neonatal 26.71 9.96 6 151635 5 64347086
Stress 26.40 9.96 65 151576 60469 64286622
Non-24-hour sleep-wake disorder 26.37 9.96 8 151633 39 64347052
Hypoaesthesia 26.34 9.96 205 151436 138903 64208188
Intentional product use issue 26.21 9.96 125 151516 95239 64251852
Lennox-Gastaut syndrome 26.14 9.96 12 151629 210 64346881
Constipation 25.96 9.96 381 151260 228956 64118135
Tongue biting 25.93 9.96 26 151615 1734 64345357
Product packaging confusion 25.69 9.96 12 151629 219 64346872
Diabetes mellitus inadequate control 25.68 9.96 9 151632 21312 64325779
Localised infection 25.61 9.96 20 151621 30141 64316950
Attention deficit hyperactivity disorder 25.46 9.96 32 151609 2738 64344353
Pleocytosis 25.45 9.96 21 151620 1086 64346005
Rash scarlatiniform 25.44 9.96 12 151629 224 64346867
Sciatica 25.37 9.96 8 151633 20256 64326835
Pulmonary hypertension 25.16 9.96 39 151602 43100 64303991
Gliosis 25.05 9.96 14 151627 377 64346714
Heart rate increased 25.03 9.96 133 151508 98542 64248549
Abulia 24.99 9.96 19 151622 872 64346219
Major depression 24.78 9.96 56 151585 7760 64339331
Dry mouth 24.72 9.96 67 151574 60351 64286740
Necrobiosis lipoidica diabeticorum 24.59 9.96 7 151634 26 64347065
Brain abscess 24.58 9.96 39 151602 4142 64342949
Lethargy 24.55 9.96 270 151371 72324 64274767
Opsoclonus myoclonus 24.47 9.96 11 151630 183 64346908
Ultrasound ovary abnormal 24.40 9.96 9 151632 87 64347004
Bradykinesia 24.24 9.96 50 151591 6510 64340581
Fall 24.22 9.96 1205 150436 415621 63931470
Bone pain 24.11 9.96 47 151594 47525 64299566
Angiomyolipoma 24.04 9.96 11 151630 191 64346900
Cerebellar atrophy 24.01 9.96 20 151621 1048 64346043
Brain tumour operation 23.99 9.96 7 151634 29 64347062
Upper respiratory tract infection 23.96 9.96 89 151552 72696 64274395
Lymphangioleiomyomatosis 23.87 9.96 10 151631 139 64346952
Throat irritation 23.82 9.96 25 151616 32686 64314405
CSF measles antibody positive 23.82 9.96 8 151633 57 64347034
Device expulsion 23.67 9.96 10 151631 21126 64325965
Neonatal pneumonia 23.62 9.96 7 151634 31 64347060
Neonatal hypotension 23.62 9.96 7 151634 31 64347060
Rubella antibody positive 23.35 9.96 8 151633 61 64347030
Depression 23.31 9.96 580 151061 182711 64164380
Gastric ulcer 23.29 9.96 22 151619 30212 64316879
Weight increased 23.26 9.96 357 151284 212991 64134100
Musculoskeletal discomfort 23.10 9.96 5 151636 16272 64330819
Folliculitis 23.03 9.96 22 151619 30055 64317036
Mitral valve incompetence 22.89 9.96 16 151625 25522 64321569
Rhesus incompatibility 22.85 9.96 6 151635 15 64347076
Bladder sphincter atony 22.82 9.96 9 151632 106 64346985
Meningitis aseptic 22.75 9.96 45 151596 5685 64341406
Mucosal ulceration 22.71 9.96 24 151617 1703 64345388
Ischaemic stroke 22.67 9.96 131 151510 28904 64318187
Movement disorder 22.51 9.96 107 151534 21893 64325198
Metastases to central nervous system 22.50 9.96 78 151563 13834 64333257
Weight decreased 22.48 9.96 506 151135 285233 64061858
Brain neoplasm malignant 22.46 9.96 20 151621 1148 64345943
Sputum discoloured 22.45 9.96 7 151634 17849 64329242
Neck pain 22.45 9.96 72 151569 61461 64285630
Drug level below therapeutic 22.41 9.96 52 151589 7332 64339759
Metastases to bone 22.35 9.96 10 151631 20425 64326666
Axillary lymphadenectomy 22.35 9.96 5 151636 4 64347087
Pneumonia 22.27 9.96 1082 150559 558494 63788597
Heart rate irregular 22.25 9.96 19 151622 27394 64319697
Staphylococcal scalded skin syndrome 22.08 9.96 13 151628 387 64346704
Intentional overdose 22.03 9.96 315 151326 89629 64257462
Craniocerebral injury 21.91 9.96 37 151604 4139 64342952
Pulmonary valve stenosis congenital 21.82 9.96 5 151636 5 64347086
Alcohol use disorder 21.81 9.96 6 151635 19 64347072
Bronchospasm 21.62 9.96 12 151629 21670 64325421
Arteriosclerosis coronary artery 21.57 9.96 5 151636 15524 64331567
Accidental overdose 21.55 9.96 144 151497 33413 64313678
Breast cancer 21.54 9.96 22 151619 29126 64317965
Diabetic ketoacidosis 21.52 9.96 23 151618 29822 64317269
Cold sweat 21.51 9.96 6 151635 16449 64330642
Crying 21.51 9.96 99 151542 19991 64327100
Throat tightness 21.44 9.96 14 151627 23146 64323945
Catastrophic reaction 21.36 9.96 6 151635 21 64347070
Renal fusion anomaly 21.35 9.96 5 151636 6 64347085
Cerebral venous sinus thrombosis 21.29 9.96 24 151617 1831 64345260
Language disorder 21.26 9.96 29 151612 2688 64344403
Paraplegia 21.23 9.96 38 151603 4452 64342639
Presyncope 21.16 9.96 31 151610 35058 64312033
Neurosurgery 21.14 9.96 6 151635 22 64347069
Diverticulum 21.02 9.96 3 151638 13195 64333896
Brain herniation 20.93 9.96 47 151594 6486 64340605
Ear pain 20.92 9.96 17 151624 25119 64321972
Metabolic acidosis 20.91 9.96 257 151384 70701 64276390
Pain in jaw 20.89 9.96 40 151601 40715 64306376
Dysmorphism 20.88 9.96 14 151627 526 64346565
Agnosia 20.85 9.96 10 151631 194 64346897
Anaphylactic reaction 20.67 9.96 87 151554 68577 64278514
Astrocytoma 20.62 9.96 10 151631 199 64346892
Nervous system disorder 20.61 9.96 108 151533 22970 64324121
Type 2 diabetes mellitus 20.57 9.96 30 151611 33990 64313101
Head injury 20.54 9.96 140 151501 32702 64314389
Congenital renal disorder 20.52 9.96 5 151636 8 64347083
Gastric disorder 20.50 9.96 23 151618 29174 64317917
Speech disorder developmental 20.44 9.96 14 151627 545 64346546
Carpal tunnel syndrome 20.27 9.96 6 151635 15822 64331269
Coronary artery occlusion 20.26 9.96 4 151637 13887 64333204
Ill-defined disorder 20.25 9.96 46 151595 44006 64303085
Guillain-Barre syndrome 20.21 9.96 51 151590 7584 64339507
Psychomotor disadaptation syndrome 20.17 9.96 6 151635 27 64347064
Osteochondrosis 20.15 9.96 21 151620 1466 64345625
Blood lactic acid increased 20.14 9.96 62 151579 10339 64336752
Poverty of thought content 20.14 9.96 7 151634 56 64347035
Psychomotor retardation 19.95 9.96 40 151601 5103 64341988
Selective eating disorder 19.92 9.96 10 151631 215 64346876
Drug-induced liver injury 19.85 9.96 185 151456 47458 64299633
Ulcer 19.83 9.96 15 151626 22975 64324116
Congenital inguinal hernia 19.81 9.96 5 151636 10 64347081
Product name confusion 19.74 9.96 9 151632 155 64346936
Ascites 19.64 9.96 77 151564 61924 64285167
Dysphemia 19.60 9.96 30 151611 3089 64344002
Angina unstable 19.56 9.96 6 151635 15461 64331630
Gingival hypertrophy 19.53 9.96 28 151613 2719 64344372
Blood cholesterol increased 19.39 9.96 57 151584 50009 64297082
Hypocalcaemia 19.39 9.96 166 151475 41587 64305504
Injection site warmth 19.38 9.96 4 151637 13458 64333633
Slow response to stimuli 19.26 9.96 21 151620 1544 64345547
Epileptic encephalopathy 19.22 9.96 12 151629 398 64346693
Crystal nephropathy 19.21 9.96 19 151622 1246 64345845
Hepatic enzyme increased 19.15 9.96 204 151437 129739 64217352
Intestinal obstruction 19.14 9.96 35 151606 36251 64310840
Intrauterine infection 19.13 9.96 7 151634 66 64347025
Placental infarction 19.11 9.96 8 151633 111 64346980
Osteomyelitis 19.08 9.96 22 151619 27565 64319526
Mobility decreased 18.94 9.96 121 151520 85719 64261372
Bile acid malabsorption 18.89 9.96 9 151632 172 64346919
Glycosylated haemoglobin increased 18.89 9.96 7 151634 16012 64331079
Radiation necrosis 18.88 9.96 11 151630 321 64346770
Basal cell carcinoma 18.84 9.96 27 151614 30811 64316280
Haematochezia 18.82 9.96 86 151555 66287 64280804
Hypersensitivity vasculitis 18.78 9.96 46 151595 6715 64340376
Multiple organ dysfunction syndrome 18.77 9.96 339 151302 101074 64246017
Herpes simplex encephalitis 18.71 9.96 14 151627 627 64346464
Unresponsive to stimuli 18.71 9.96 191 151450 50202 64296889
Personality disorder 18.71 9.96 37 151604 4674 64342417
Executive dysfunction 18.71 9.96 10 151631 246 64346845
Gamma-glutamyltransferase increased 18.55 9.96 185 151456 48325 64298766
Craniotomy 18.55 9.96 11 151630 332 64346759
Feeling cold 18.51 9.96 17 151624 23661 64323430
Administration site discomfort 18.48 9.96 8 151633 121 64346970
Atrioventricular block complete 18.46 9.96 75 151566 14343 64332748
Gout 18.43 9.96 14 151627 21399 64325692
Injection site rash 18.36 9.96 7 151634 15735 64331356
Heart rate decreased 18.34 9.96 67 151574 55000 64292091
Injection site haemorrhage 18.31 9.96 18 151623 24260 64322831
Transplant rejection 18.29 9.96 9 151632 17392 64329699
Prostate cancer 18.28 9.96 12 151629 19783 64327308
Central nervous system infection 18.26 9.96 18 151623 1176 64345915
Cardiopulmonary failure 18.23 9.96 43 151598 6127 64340964
Lipids 18.14 9.96 5 151636 16 64347075
Conjunctival irritation 18.08 9.96 8 151633 128 64346963
Use of accessory respiratory muscles 18.06 9.96 11 151630 349 64346742
Eye pain 18.06 9.96 29 151612 31596 64315495
Blood urea increased 18.03 9.96 49 151592 44104 64302987
Pulmonary embolism 18.03 9.96 239 151402 146117 64200974
Wrong patient received product 18.00 9.96 32 151609 3730 64343361
Macroglossia 17.97 9.96 17 151624 1055 64346036
Blood brain barrier defect 17.97 9.96 8 151633 130 64346961
Medication error 17.89 9.96 188 151453 49778 64297313
Ehlers-Danlos syndrome 17.86 9.96 8 151633 132 64346959
Nodule 17.80 9.96 10 151631 17937 64329154
Temporal lobe epilepsy 17.73 9.96 11 151630 361 64346730
COVID-19 immunisation 17.66 9.96 13 151628 568 64346523
Loss of personal independence in daily activities 17.63 9.96 99 151542 72355 64274736
CSF protein increased 17.53 9.96 17 151624 1088 64346003
Joint range of motion decreased 17.49 9.96 12 151629 19331 64327760
SJS-TEN overlap 17.47 9.96 12 151629 469 64346622
Limb discomfort 17.40 9.96 23 151618 27152 64319939
Apnoea 17.35 9.96 59 151582 10363 64336728
Anaplastic astrocytoma 17.28 9.96 8 151633 143 64346948
Blood gases abnormal 17.27 9.96 16 151625 967 64346124
Device malfunction 17.24 9.96 10 151631 17623 64329468
Cytomegalovirus hepatitis 17.15 9.96 13 151628 594 64346497
Skin disorder 17.14 9.96 24 151617 27656 64319435
Abdominal distension 17.01 9.96 144 151497 95850 64251241
Thunderclap headache 17.00 9.96 9 151632 217 64346874
Maternal drugs affecting foetus 16.98 9.96 20 151621 1600 64345491
Gastric pH increased 16.94 9.96 6 151635 51 64347040
Illness 16.85 9.96 16 151625 21922 64325169
Device dislocation 16.80 9.96 15 151626 21163 64325928
Ocular hyperaemia 16.71 9.96 17 151624 22547 64324544
Myocardial ischaemia 16.67 9.96 18 151623 23233 64323858
Dystonia 16.65 9.96 88 151553 18777 64328314
Product dispensing error 16.65 9.96 62 151579 11388 64335703
Dysmetria 16.55 9.96 15 151626 881 64346210
C-reactive protein increased 16.53 9.96 143 151498 94766 64252325
Erythema multiforme 16.53 9.96 77 151564 15624 64331467
Hypertonia 16.48 9.96 42 151599 6283 64340808
Squamous cell carcinoma 16.45 9.96 6 151635 13863 64333228
Myositis 16.43 9.96 9 151632 16368 64330723
Retinitis viral 16.41 9.96 7 151634 102 64346989
Gait disturbance 16.37 9.96 525 151116 171630 64175461
Epileptic psychosis 16.36 9.96 6 151635 57 64347034
Bladder cancer 16.35 9.96 3 151638 10971 64336120
Euthyroid sick syndrome 16.27 9.96 6 151635 58 64347033
Headache 16.23 9.96 1050 150591 528417 63818674
Metastases to meninges 16.19 9.96 26 151615 2789 64344302
Squamous cell carcinoma of skin 16.15 9.96 4 151637 11872 64335219
Musculoskeletal chest pain 16.11 9.96 16 151625 21463 64325628
Right ventricular failure 16.10 9.96 16 151625 21455 64325636
Cerebral cyst 16.07 9.96 10 151631 330 64346761
Upper gastrointestinal haemorrhage 16.01 9.96 37 151604 35183 64311908
Cerebellar syndrome 15.97 9.96 36 151605 4980 64342111
Thrombosis 15.88 9.96 99 151542 70543 64276548
Neutropenia 15.87 9.96 702 150939 238922 64108169
Cortical dysplasia 15.85 9.96 4 151637 8 64347083
Blood urine present 15.77 9.96 12 151629 18328 64328763
Hepatic cytolysis 15.61 9.96 70 151571 13979 64333112
Vitamin B6 decreased 15.53 9.96 4 151637 9 64347082
Polychromasia 15.50 9.96 9 151632 261 64346830
Gastritis 15.45 9.96 50 151591 42568 64304523
Hyperchloraemia 15.42 9.96 15 151626 964 64346127
Cholelithiasis 15.40 9.96 55 151586 45451 64301640
Vasogenic cerebral oedema 15.37 9.96 15 151626 968 64346123
Rectal haemorrhage 15.30 9.96 84 151557 61733 64285358
Hepatic function abnormal 15.26 9.96 224 151417 64089 64283002
Emphysema 15.21 9.96 7 151634 14062 64333029
Oligodendroglioma 15.19 9.96 6 151635 71 64347020
Petechiae 15.17 9.96 85 151556 18541 64328550
Ganglioglioma 15.17 9.96 3 151638 0 64347091
Unmasking of previously unidentified disease 15.10 9.96 19 151622 1628 64345463
Pancreatitis 15.09 9.96 210 151431 59397 64287694
Haemorrhagic transformation stroke 15.04 9.96 23 151618 2366 64344725
Palmar-plantar erythrodysaesthesia syndrome 15.02 9.96 28 151613 28791 64318300
Interstitial lung disease 14.99 9.96 152 151489 97580 64249511
Glaucoma 14.97 9.96 10 151631 16338 64330753
Porphyria 14.96 9.96 8 151633 197 64346894
Contraindicated product prescribed 14.96 9.96 16 151625 1151 64345940
Pharyngeal oedema 14.91 9.96 9 151632 15522 64331569
Coronary artery stenosis 14.89 9.96 4 151637 11244 64335847
Leukoencephalopathy 14.88 9.96 43 151598 6924 64340167
Coagulopathy 14.87 9.96 127 151514 31793 64315298
Subacute sclerosing panencephalitis 14.84 9.96 5 151636 36 64347055
Slow speech 14.83 9.96 21 151620 2016 64345075
Gallbladder disorder 14.83 9.96 11 151630 17019 64330072
Product residue present 14.77 9.96 27 151614 3215 64343876
Hypotonia neonatal 14.75 9.96 6 151635 77 64347014
Biopsy brain 14.70 9.96 4 151637 12 64347079
Device issue 14.67 9.96 19 151622 22629 64324462
Acquired macroglossia 14.67 9.96 8 151633 205 64346886
Sinus disorder 14.62 9.96 11 151630 16897 64330194
Acute disseminated encephalomyelitis 14.62 9.96 9 151632 291 64346800
Quadriparesis 14.57 9.96 25 151616 2832 64344259
Niemann-Pick disease 14.49 9.96 5 151636 39 64347052
Gene mutation 14.48 9.96 21 151620 2061 64345030
Ovarian cyst 14.43 9.96 4 151637 11014 64336077
Burnout syndrome 14.40 9.96 9 151632 299 64346792
Accidental exposure to product by child 14.36 9.96 23 151618 2462 64344629
Back disorder 14.32 9.96 3 151638 9987 64337104
Faeces discoloured 14.31 9.96 24 151617 25705 64321386
Poor personal hygiene 14.30 9.96 11 151630 514 64346577
Acquired immunodeficiency syndrome 14.29 9.96 8 151633 216 64346875
Blood pressure systolic abnormal 14.22 9.96 3 151638 9939 64337152
Neurodevelopmental disorder 14.17 9.96 5 151636 42 64347049
Infective pulmonary exacerbation of cystic fibrosis 14.17 9.96 5 151636 11791 64335300
Blood pressure diastolic decreased 14.15 9.96 19 151622 22282 64324809
Cytomegalovirus gastritis 14.12 9.96 10 151631 411 64346680
Eastern Cooperative Oncology Group performance status worsened 14.07 9.96 16 151625 1232 64345859
Cytotoxic oedema 14.04 9.96 9 151632 313 64346778
Glioma 14.02 9.96 11 151630 529 64346562
Irregular sleep wake rhythm disorder 13.99 9.96 9 151632 315 64346776
Aplasia 13.98 9.96 42 151599 6911 64340180
Injection site mass 13.98 9.96 12 151629 17258 64329833
Cell death 13.93 9.96 30 151611 4024 64343067
Laryngeal stenosis 13.92 9.96 13 151628 794 64346297
Drug clearance increased 13.90 9.96 8 151633 228 64346863
Schizophreniform disorder 13.88 9.96 7 151634 152 64346939
Bronchiectasis 13.85 9.96 8 151633 14132 64332959
Musculoskeletal disorder 13.83 9.96 13 151628 17893 64329198
Laboratory test abnormal 13.80 9.96 22 151619 24041 64323050
Cerebral atrophy 13.71 9.96 43 151598 7242 64339849
Haemorrhoids 13.71 9.96 22 151619 23979 64323112
Hiatus hernia 13.71 9.96 16 151625 19941 64327150
Inappropriate affect 13.66 9.96 16 151625 1272 64345819
Product administered to patient of inappropriate age 13.53 9.96 32 151609 4569 64342522
Completed suicide 13.51 9.96 413 151228 224001 64123090
Disorganised speech 13.51 9.96 18 151623 1632 64345459
Astrocytoma, low grade 13.49 9.96 5 151636 49 64347042
Lower gastrointestinal haemorrhage 13.49 9.96 8 151633 13931 64333160
Hypersexuality 13.46 9.96 17 151624 1462 64345629
Patent ductus arteriosus 13.39 9.96 6 151635 99 64346992
Multiple congenital abnormalities 13.39 9.96 6 151635 99 64346992
Twin pregnancy 13.38 9.96 13 151628 834 64346257
Respiratory tract congestion 13.37 9.96 11 151630 16154 64330937
Disinhibition 13.29 9.96 21 151620 2222 64344869
Congenital anomaly 13.27 9.96 8 151633 249 64346842
Colitis ulcerative 13.26 9.96 21 151620 23007 64324084
Tenderness 13.16 9.96 16 151625 19586 64327505
Screaming 13.16 9.96 27 151614 3502 64343589
Tendonitis 13.15 9.96 17 151624 20265 64326826
Paresis 13.14 9.96 27 151614 3505 64343586
Bradyarrhythmia 13.13 9.96 28 151613 3730 64343361
Circadian rhythm sleep disorder 13.13 9.96 11 151630 581 64346510
Rotator cuff syndrome 13.13 9.96 6 151635 12101 64334990
Delusional disorder, mixed type 13.09 9.96 3 151638 3 64347088
Renal impairment 13.04 9.96 231 151410 134786 64212305
Dyscalculia 12.98 9.96 5 151636 55 64347036
Loss of consciousness 12.96 9.96 448 151193 147917 64199174
Encephalocele 12.94 9.96 4 151637 21 64347070
White matter lesion 12.91 9.96 18 151623 1704 64345387
Brain injury 12.89 9.96 52 151589 9913 64337178
Cholecystitis chronic 12.88 9.96 3 151638 9284 64337807
Renal tubular disorder 12.84 9.96 37 151604 5950 64341141
Pulmonary mass 12.81 9.96 23 151618 23993 64323098
Therapeutic response shortened 12.76 9.96 4 151637 10166 64336925
Haematuria traumatic 12.71 9.96 7 151634 183 64346908
Metastases to liver 12.71 9.96 23 151618 23918 64323173
Blood osmolarity decreased 12.70 9.96 15 151626 1203 64345888
Perseveration 12.64 9.96 9 151632 373 64346718
Amniorrhexis 12.64 9.96 4 151637 23 64347068
Mean cell volume increased 12.63 9.96 33 151608 5013 64342078
Hyperkinesia 12.62 9.96 22 151619 2524 64344567
Wrong patient 12.57 9.96 7 151634 187 64346904
Acute kidney injury 12.57 9.96 898 150743 448342 63898749
Renal failure 12.55 9.96 328 151313 181360 64165731
Pregnancy on oral contraceptive 12.49 9.96 12 151629 759 64346332
Lipids abnormal 12.48 9.96 10 151631 496 64346595
Rash 12.45 9.96 919 150722 457630 63889461
Mitochondrial cytopathy 12.41 9.96 9 151632 384 64346707
Juvenile myoclonic epilepsy 12.37 9.96 5 151636 63 64347028
Consciousness fluctuating 12.36 9.96 17 151624 1588 64345503
Acute myeloid leukaemia 12.36 9.96 29 151612 27434 64319657
Vitamin B6 deficiency 12.36 9.96 8 151633 283 64346808
Encephalomalacia 12.33 9.96 14 151627 1077 64346014
Breath sounds abnormal 12.32 9.96 6 151635 11663 64335428
Product prescribing error 12.30 9.96 132 151509 35137 64311954
Urge incontinence 12.29 9.96 13 151628 923 64346168
Procedural pain 12.28 9.96 11 151630 15497 64331594
Mental impairment 12.28 9.96 73 151568 16270 64330821
Hemiplegia 12.27 9.96 61 151580 12707 64334384
Therapeutic product ineffective for unapproved indication 12.26 9.96 6 151635 122 64346969
Anticonvulsant drug level abnormal 12.23 9.96 5 151636 65 64347026
Prolonged pregnancy 12.22 9.96 4 151637 26 64347065
Lung disorder 12.17 9.96 88 151553 60612 64286479
Drug clearance decreased 12.17 9.96 22 151619 2597 64344494
Sinus congestion 12.17 9.96 11 151630 15428 64331663
Chemotherapeutic drug level above therapeutic 12.17 9.96 5 151636 66 64347025
Magnetic resonance imaging head abnormal 12.17 9.96 21 151620 2391 64344700
Learning disability 12.15 9.96 7 151634 200 64346891
Sialoadenitis 12.14 9.96 17 151624 1616 64345475
Duplicate therapy error 12.12 9.96 7 151634 201 64346890
Cerebral artery stenosis 12.11 9.96 11 151630 648 64346443
Primary mediastinal large B-cell lymphoma 12.09 9.96 4 151637 27 64347064
Astrocytoma malignant 12.09 9.96 4 151637 27 64347064
Carnitine deficiency 12.09 9.96 7 151634 202 64346889
Erythema 12.07 9.96 341 151300 186729 64160362
Pregnancy with implant contraceptive 12.03 9.96 16 151625 1448 64345643
Abortion threatened 12.01 9.96 9 151632 404 64346687
Fistula 11.96 9.96 4 151637 9757 64337334
Coma acidotic 11.95 9.96 6 151635 129 64346962
Sinus arrest 11.95 9.96 24 151617 3066 64344025
Graft versus host disease 11.93 9.96 9 151632 13804 64333287
Exostosis 11.89 9.96 6 151635 11432 64335659
Gerstmann's syndrome 11.88 9.96 3 151638 6 64347085
Congenital renal cyst 11.88 9.96 3 151638 6 64347085
Mixed liver injury 11.88 9.96 34 151607 5447 64341644
Dry skin 11.86 9.96 71 151570 51090 64296001
Mucocutaneous rash 11.85 9.96 4 151637 29 64347062
Prostatic specific antigen increased 11.82 9.96 3 151638 8757 64338334
Renal disorder 11.80 9.96 43 151598 35322 64311769
Primary mediastinal large B-cell lymphoma recurrent 11.77 9.96 5 151636 72 64347019
Drug dose titration not performed 11.77 9.96 11 151630 672 64346419
Unevaluable event 11.74 9.96 70 151571 50419 64296672
Salivary hypersecretion 11.74 9.96 58 151583 12055 64335036
Metastases to lymph nodes 11.73 9.96 3 151638 8714 64338377
Femur fracture 11.72 9.96 41 151600 34094 64312997
Unintended pregnancy 11.71 9.96 24 151617 3110 64343981
Hypometabolism 11.65 9.96 5 151636 74 64347017
Iron deficiency anaemia 11.64 9.96 21 151620 21868 64325223
Gastritis erosive 11.64 9.96 4 151637 9591 64337500
Violence-related symptom 11.61 9.96 11 151630 684 64346407
Cerebral amyloid angiopathy 11.60 9.96 8 151633 315 64346776
Clonus 11.59 9.96 36 151605 6031 64341060
Incoherent 11.59 9.96 40 151601 7078 64340013
Illogical thinking 11.59 9.96 5 151636 75 64347016
Blood glucose decreased 11.58 9.96 23 151618 23100 64323991
Impaired self-care 11.49 9.96 20 151621 2293 64344798
Hyperlipasaemia 11.48 9.96 13 151628 997 64346094
Exomphalos 11.47 9.96 5 151636 77 64347014
Restless legs syndrome 11.46 9.96 14 151627 17102 64329989
Full blood count abnormal 11.43 9.96 34 151607 29723 64317368
Congestive cardiomyopathy 11.41 9.96 5 151636 10339 64336752
Hemianopia 11.40 9.96 16 151625 1523 64345568
Apallic syndrome 11.40 9.96 12 151629 847 64346244
Teratoma 11.32 9.96 6 151635 145 64346946
Central nervous system haemorrhage 11.30 9.96 7 151634 229 64346862
Adverse event 11.30 9.96 51 151590 39438 64307653
Psychotic symptom 11.29 9.96 19 151622 2119 64344972
Osteopenia 11.18 9.96 12 151629 15528 64331563
Myopia 11.18 9.96 17 151624 1741 64345350
Bradypnoea 11.17 9.96 32 151609 5127 64341964
Illusion 11.16 9.96 16 151625 1554 64345537
Intracranial pressure increased 11.14 9.96 39 151602 6950 64340141
Hyperuricaemia 11.13 9.96 5 151636 10186 64336905
Flank pain 11.10 9.96 13 151628 16176 64330915
Regressive behaviour 11.08 9.96 5 151636 84 64347007
Encephalitis viral 11.07 9.96 20 151621 2360 64344731
Dermatitis exfoliative 11.07 9.96 51 151590 10301 64336790
Dysgeusia 11.06 9.96 65 151576 46982 64300109
Dropped head syndrome 11.06 9.96 7 151634 238 64346853
Large granular lymphocytosis 11.04 9.96 8 151633 341 64346750
Haematuria 11.03 9.96 90 151551 60381 64286710
Congenital hydronephrosis 11.03 9.96 3 151638 9 64347082
Eyelid injury 11.03 9.96 3 151638 9 64347082
Respiratory syncytial virus bronchiolitis 11.00 9.96 9 151632 460 64346631
B-cell aplasia 10.99 9.96 6 151635 154 64346937
Grip strength decreased 10.97 9.96 7 151634 11717 64335374
Drug withdrawal headache 10.97 9.96 5 151636 86 64347005
Myelodysplastic syndrome 10.97 9.96 31 151610 27548 64319543
Onychophagia 10.92 9.96 5 151636 87 64347004
Bone disorder 10.92 9.96 14 151627 16745 64330346
CSF virus identified 10.91 9.96 4 151637 38 64347053
Automatism 10.85 9.96 6 151635 158 64346933
Tuberous sclerosis complex 10.82 9.96 5 151636 89 64347002
Temperature intolerance 10.81 9.96 3 151638 8252 64338839
High-pitched crying 10.79 9.96 3 151638 10 64347081
Oxygen saturation decreased 10.78 9.96 182 151459 106994 64240097
Mass 10.76 9.96 12 151629 15264 64331827
Intervertebral disc degeneration 10.76 9.96 9 151632 13111 64333980
Transverse sinus thrombosis 10.72 9.96 10 151631 610 64346481
Cerebral venous thrombosis 10.71 9.96 20 151621 2421 64344670
Lichenoid keratosis 10.70 9.96 24 151617 3310 64343781
Cardiac murmur 10.69 9.96 7 151634 11556 64335535
Intrusive thoughts 10.68 9.96 8 151633 359 64346732
Weight gain poor 10.59 9.96 11 151630 765 64346326
Aspiration 10.57 9.96 72 151569 16813 64330278
Transient aphasia 10.56 9.96 6 151635 167 64346924
Blood ketone body increased 10.55 9.96 10 151631 622 64346469
Febrile infection-related epilepsy syndrome 10.55 9.96 4 151637 42 64347049
Cerebral haematoma 10.53 9.96 39 151602 7146 64339945
Hyperpyrexia 10.52 9.96 31 151610 5046 64342045
Clumsiness 10.52 9.96 21 151620 2670 64344421
Blood pressure decreased 10.52 9.96 141 151500 86058 64261033
Scarlet fever 10.52 9.96 5 151636 95 64346996
Food interaction 10.51 9.96 15 151626 1451 64345640
Ovarian cancer stage III 10.46 9.96 6 151635 170 64346921
Cardiomyopathy 10.46 9.96 28 151613 25328 64321763
Bicytopenia 10.44 9.96 25 151616 3597 64343494
Meningitis 10.41 9.96 43 151598 8286 64338805
Pemphigoid 10.40 9.96 59 151582 12927 64334164
Spinal osteoarthritis 10.40 9.96 11 151630 14330 64332761
Glycosuria 10.39 9.96 18 151623 2056 64345035
Treatment failure 10.30 9.96 203 151438 116613 64230478
Tricuspid valve incompetence 10.27 9.96 15 151626 16988 64330103
Panniculitis 10.27 9.96 4 151637 8875 64338216
Dehydration 10.26 9.96 411 151230 216352 64130739
Intensive care unit delirium 10.23 9.96 4 151637 46 64347045
Hernia 10.22 9.96 10 151631 13508 64333583
Oscillopsia 10.21 9.96 6 151635 178 64346913
Respiratory failure 10.18 9.96 470 151171 160713 64186378
Potentiating drug interaction 10.18 9.96 41 151600 7811 64339280
Pulmonary function test 10.17 9.96 3 151638 13 64347078
Gastric haemorrhage 10.16 9.96 10 151631 13471 64333620
Anti-GAD antibody positive 10.15 9.96 4 151637 47 64347044
Metastatic malignant melanoma 10.14 9.96 20 151621 2521 64344570
Perforation 10.14 9.96 13 151628 1135 64345956
Colon cancer 10.13 9.96 9 151632 12730 64334361
Uveitis 10.08 9.96 9 151632 12699 64334392
Macrocephaly 10.07 9.96 4 151637 48 64347043
Upper-airway cough syndrome 10.06 9.96 4 151637 8766 64338325
Hepatitis A 10.04 9.96 11 151630 813 64346278
Parkinsonism 10.04 9.96 63 151578 14310 64332781
Obstructive airways disorder 10.03 9.96 25 151616 23160 64323931
Subarachnoid haemorrhage 10.02 9.96 76 151565 18362 64328729
Nocturia 10.00 9.96 7 151634 11158 64335933
Wrong technique in product usage process 9.98 9.96 101 151540 64873 64282218
Toothache 9.98 9.96 16 151625 17443 64329648
Pancreatic carcinoma 9.98 9.96 6 151635 10367 64336724

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Weight gain poor 39.76 24.34 21 1263 61 83333
Drug ineffective 39.52 24.34 58 1226 859 82535
Brain malformation 38.50 24.34 12 1272 0 83394
Cerebral cyst 29.00 24.34 12 1272 15 83379
Gastrooesophageal reflux disease 28.17 24.34 12 1272 17 83377

Pharmacologic Action:

SourceCodeDescription
ATC N03AX14 NERVOUS SYSTEM
ANTIEPILEPTICS
ANTIEPILEPTICS
Other antiepileptics
FDA PE N0000008486 Decreased Central Nervous System Disorganized Electrical Activity
MeSH PA D000927 Anticonvulsants
MeSH PA D002491 Central Nervous System Agents
MeSH PA D018697 Nootropic Agents
CHEBI has role CHEBI:35623 anticonvulsants
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:78298 environmental contaminants

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Epilepsy characterized by intractable complex partial seizures indication 442481002
Simple partial seizure indication 117891000119100
Partial Epilepsy Treatment Adjunct indication
Tonic-Clonic Epilepsy Treatment Adjunct indication
Myoclonic Epilepsy Adjunct Treatment indication
Suicidal thoughts contraindication 6471006
Hallucinations contraindication 7011001
Mood swings contraindication 18963009
Ataxia contraindication 20262006
Indifference contraindication 20602000
Abnormal gait contraindication 22325002
Feeling agitated contraindication 24199005
Depressive disorder contraindication 35489007
Anxiety contraindication 48694002
Feeling irritable contraindication 55929007
Aggressive behavior contraindication 61372001
Psychotic disorder contraindication 69322001
Hostile behavior contraindication 79351003
Depersonalization contraindication 79499004
Fatigue contraindication 84229001
Leukopenia contraindication 84828003 DOID:615
Kidney disease contraindication 90708001 DOID:557
Pancytopenia contraindication 127034005 DOID:12450
Disease of liver contraindication 235856003 DOID:409
Drowsy contraindication 271782001
Neutropenic disorder contraindication 303011007 DOID:1227
Behavioral Disorders contraindication




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.66 acidic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
1GM SPRITAM APRECIA PHARMS N207958 July 31, 2015 RX TABLET, FOR SUSPENSION ORAL 9339489 March 14, 2034 METHOD OF ADMINISTERING LEVETIRACETAM
1GM SPRITAM APRECIA PHARMS N207958 July 31, 2015 RX TABLET, FOR SUSPENSION ORAL 9669009 March 14, 2034 METHOD OF ADMINISTERING LEVETIRACETAM
1GM SPRITAM APRECIA PHARMS N207958 July 31, 2015 RX TABLET, FOR SUSPENSION ORAL 9669009 March 14, 2034 METHOD OF ADMINISTERING LEVETIRACETAM UNDER FASTED CONDITIONS
1GM SPRITAM APRECIA PHARMS N207958 July 31, 2015 RX TABLET, FOR SUSPENSION ORAL 9669009 March 14, 2034 METHOD OF ADMINISTERING LEVETIRACETAM UNDER FED CONDITIONS
250MG SPRITAM APRECIA PHARMS N207958 July 31, 2015 RX TABLET, FOR SUSPENSION ORAL 9339489 March 14, 2034 METHOD OF ADMINISTERING LEVETIRACETAM
250MG SPRITAM APRECIA PHARMS N207958 July 31, 2015 RX TABLET, FOR SUSPENSION ORAL 9669009 March 14, 2034 METHOD OF ADMINISTERING LEVETIRACETAM
250MG SPRITAM APRECIA PHARMS N207958 July 31, 2015 RX TABLET, FOR SUSPENSION ORAL 9669009 March 14, 2034 METHOD OF ADMINISTERING LEVETIRACETAM UNDER FASTED CONDITIONS
250MG SPRITAM APRECIA PHARMS N207958 July 31, 2015 RX TABLET, FOR SUSPENSION ORAL 9669009 March 14, 2034 METHOD OF ADMINISTERING LEVETIRACETAM UNDER FED CONDITIONS
500MG SPRITAM APRECIA PHARMS N207958 July 31, 2015 RX TABLET, FOR SUSPENSION ORAL 9339489 March 14, 2034 METHOD OF ADMINISTERING LEVETIRACETAM
500MG SPRITAM APRECIA PHARMS N207958 July 31, 2015 RX TABLET, FOR SUSPENSION ORAL 9669009 March 14, 2034 METHOD OF ADMINISTERING LEVETIRACETAM
500MG SPRITAM APRECIA PHARMS N207958 July 31, 2015 RX TABLET, FOR SUSPENSION ORAL 9669009 March 14, 2034 METHOD OF ADMINISTERING LEVETIRACETAM UNDER FASTED CONDITIONS
500MG SPRITAM APRECIA PHARMS N207958 July 31, 2015 RX TABLET, FOR SUSPENSION ORAL 9669009 March 14, 2034 METHOD OF ADMINISTERING LEVETIRACETAM UNDER FED CONDITIONS
750MG SPRITAM APRECIA PHARMS N207958 July 31, 2015 RX TABLET, FOR SUSPENSION ORAL 9339489 March 14, 2034 METHOD OF ADMINISTERING LEVETIRACETAM
750MG SPRITAM APRECIA PHARMS N207958 July 31, 2015 RX TABLET, FOR SUSPENSION ORAL 9669009 March 14, 2034 METHOD OF ADMINISTERING LEVETIRACETAM
750MG SPRITAM APRECIA PHARMS N207958 July 31, 2015 RX TABLET, FOR SUSPENSION ORAL 9669009 March 14, 2034 METHOD OF ADMINISTERING LEVETIRACETAM UNDER FASTED CONDITIONS
750MG SPRITAM APRECIA PHARMS N207958 July 31, 2015 RX TABLET, FOR SUSPENSION ORAL 9669009 March 14, 2034 METHOD OF ADMINISTERING LEVETIRACETAM UNDER FED CONDITIONS

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Synaptic vesicle glycoprotein 2A Transporter MODULATOR Ki 6.10 CHEMBL CHEMBL
Sodium channel protein type 1 subunit alpha Ion channel WOMBAT-PK
Voltage-dependent T-type calcium channel subunit alpha-1G Ion channel WOMBAT-PK
Carbonic anhydrase 1 Enzyme WOMBAT-PK
Synaptic vesicle glycoprotein 2A Unclassified INHIBITOR IC50 6.10 IUPHAR

External reference:

IDSource
D00709 KEGG_DRUG
4021198 VANDF
C0377265 UMLSCUI
CHEBI:6437 CHEBI
CHEMBL1286 ChEMBL_ID
DB01202 DRUGBANK_ID
D000077287 MESH_DESCRIPTOR_UI
5284583 PUBCHEM_CID
6450 INN_ID
6826 IUPHAR_LIGAND_ID
44YRR34555 UNII
114477 RXNORM
31546 MMSL
66397 MMSL
8574 MMSL
d04499 MMSL
008058 NDDF
116076009 SNOMEDCT_US
387000003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0121-0799 SOLUTION 100 mg ORAL ANDA 27 sections
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0121-1598 SOLUTION 1000 mg ORAL ANDA 27 sections
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0121-2397 SOLUTION 1500 mg ORAL ANDA 27 sections
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0121-4799 SOLUTION 500 mg ORAL ANDA 27 sections
LEVETIRACETAM HUMAN PRESCRIPTION DRUG LABEL 1 0121-4802 SOLUTION 100 mg ORAL ANDA 27 sections
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0143-9574 INJECTION 100 mg INTRAVENOUS ANDA 26 sections
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0143-9673 INJECTION 100 mg INTRAVENOUS ANDA 26 sections
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0378-5613 TABLET, FILM COATED 250 mg ORAL ANDA 29 sections
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0378-5615 TABLET, FILM COATED 500 mg ORAL ANDA 29 sections
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0378-5617 TABLET, FILM COATED 750 mg ORAL ANDA 29 sections
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0378-5619 TABLET, FILM COATED 1000 mg ORAL ANDA 29 sections
LEVETIRACETAM HUMAN PRESCRIPTION DRUG LABEL 1 0409-1886 INJECTION, SOLUTION 100 mg INTRAVENOUS ANDA 28 sections
LEVETIRACETAM HUMAN PRESCRIPTION DRUG LABEL 1 0409-1886 INJECTION, SOLUTION 100 mg INTRAVENOUS ANDA 28 sections
LEVETIRACETAM HUMAN PRESCRIPTION DRUG LABEL 1 0409-1886 INJECTION, SOLUTION 100 mg INTRAVENOUS ANDA 28 sections
LEVETIRACETAM HUMAN PRESCRIPTION DRUG LABEL 1 0409-1886 INJECTION, SOLUTION 100 mg INTRAVENOUS ANDA 28 sections
LEVETIRACETAM HUMAN PRESCRIPTION DRUG LABEL 1 0409-2011 INJECTION, SOLUTION 100 mg INTRAVENOUS ANDA 28 sections
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0472-0235 SOLUTION 100 mg ORAL ANDA 17 sections
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0615-7976 TABLET, FILM COATED 250 mg ORAL ANDA 27 sections
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0615-7977 TABLET, FILM COATED 500 mg ORAL ANDA 27 sections
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0615-7978 TABLET, FILM COATED 750 mg ORAL ANDA 27 sections
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0615-7979 TABLET, FILM COATED 1000 mg ORAL ANDA 26 sections
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0904-6051 TABLET 250 mg ORAL ANDA 19 sections
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0904-6052 TABLET 500 mg ORAL ANDA 19 sections
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0904-6053 TABLET 750 mg ORAL ANDA 19 sections
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0904-7060 SOLUTION 500 mg ORAL ANDA 26 sections
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0904-7123 TABLET, FILM COATED 250 mg ORAL ANDA 26 sections
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0904-7124 TABLET, FILM COATED 500 mg ORAL ANDA 26 sections
Levetiracetam HUMAN PRESCRIPTION DRUG LABEL 1 0904-7125 TABLET, FILM COATED 750 mg ORAL ANDA 26 sections
LEVETIRACETAM HUMAN PRESCRIPTION DRUG LABEL 1 10135-695 SOLUTION 100 mg ORAL ANDA 30 sections
levetiracetamextended-release HUMAN PRESCRIPTION DRUG LABEL 1 10370-195 TABLET, FILM COATED, EXTENDED RELEASE 500 mg ORAL ANDA 26 sections