levamfetamine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1562 156-34-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • levamphetamine
  • levoamphetamine
  • R-Amphetamine
  • L-Amphetamine
  • levamfetamine
  • levamfetamine succinate
  • Molecular weight: 135.21
  • Formula: C9H13N
  • CLOGP: 1.74
  • LIPINSKI: 0
  • HAC: 1
  • HDO: 1
  • TPSA: 26.02
  • ALOGS: -1.89
  • ROTB: 2

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D018663 Adrenergic Agents
MeSH PA D018759 Adrenergic Uptake Inhibitors
MeSH PA D002491 Central Nervous System Agents
MeSH PA D000697 Central Nervous System Stimulants
MeSH PA D015259 Dopamine Agents
MeSH PA D018765 Dopamine Uptake Inhibitors
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D014179 Neurotransmitter Uptake Inhibitors
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D013566 Sympathomimetics

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.89 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Trace amine-associated receptor 1 GPCR EC50 6.60 CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 4.33 CHEMBL
Trace amine-associated receptor 1 GPCR EC50 7.47 CHEMBL
Trace amine-associated receptor 1 GPCR EC50 7.19 CHEMBL
Serotonin (5-HT) receptor GPCR Kd 5.16 CHEMBL
Trace amine-associated receptor 1 GPCR EC50 5.73 CHEMBL

External reference:

IDSource
D04704 KEGG_DRUG
5634-40-2 SECONDARY_CAS_RN
C0023567 UMLSCUI
CHEBI:42724 CHEBI
FRD PDB_CHEM_ID
CHEMBL19393 ChEMBL_ID
CHEMBL2106371 ChEMBL_ID
D000661 MESH_DESCRIPTOR_UI
1313 INN_ID
R87US8P740 UNII
32893 PUBCHEM_CID
85242006 SNOMEDCT_US

Pharmaceutical products:

None