amidefrine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
sympathomimetic, phenethyl derivatives	155	37571-84-9

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

amidefrine mesilate
amidephrine
amidefrine
(+/-)-Amidephrine
amidephrine mesylate
amidefrine mesylate
amidephrine mesilate

Molecular weight: 244.31
Formula: C10H16N2O3S
CLOGP: -0.61
LIPINSKI: 0
HAC: 5
HDO: 3
TPSA: 78.43
ALOGS: -1.74
ROTB: 4

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
MeSH PA	D018663	Adrenergic Agents
MeSH PA	D000322	Adrenergic Agonists
MeSH PA	D000316	Adrenergic alpha-Agonists
MeSH PA	D018377	Neurotransmitter Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	8.57	acidic
pKa2	9.11	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Adrenergic receptor alpha-2	GPCR		ADA2B_RAT ADA2C_RAT ADA2A_RAT		IC50	4.72		CHEMBL
Adrenergic receptor alpha-1	GPCR		ADA1B_RAT ADA1D_RAT ADA1A_RAT		IC50	4.40		CHEMBL

External reference:

ID	Source
D02901	KEGG_DRUG
C0051584	UMLSCUI
CHEBI:134994	CHEBI
CHEMBL146408	ChEMBL_ID
DB16623	DRUGBANK_ID
C016980	MESH_SUPPLEMENTAL_RECORD_UI
C001998	MESH_SUPPLEMENTAL_RECORD_UI
514	IUPHAR_LIGAND_ID
1421-68-7	SECONDARY_CAS_RN
15010	PUBCHEM_CID
1751	INN_ID
7E2P22546V	UNII

Pharmaceutical products:

None