All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

latanoprost 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
prostaglandins	1551	130209-82-4

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: roclanda latanoprost xalatan (15R)-Latanoprost PhXA41	A prostaglandin F analog used to treat OCULAR HYPERTENSION in patients with GLAUCOMA. Molecular weight: 432.60 Formula: C26H40O5 CLOGP: 3.60 LIPINSKI: 0 HAC: 5 HDO: 3 TPSA: 86.99 ALOGS: -4.53 ROTB: 14 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Drug dosage:

None

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	2	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	0.05 mg/mL	Benet LZ, Broccatelli F, Oprea TI
CL (Clearance)	6.70 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.10 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	0.28 hours	Lombardo F, Berellini G, Obach RS

Approvals:

Date	Agency	Company	Orphan
Jan. 7, 2021	EMA	AERIE PHARMACEUTICALS IRELAND LIMITED
June 5, 1996	FDA	PHARMACIA AND UPJOHN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Eye irritation	1289.46	12.28	479	35145	21492	63431906
Treatment failure	1013.05	12.28	859	34765	198184	63255214
Intraocular pressure increased	840.85	12.28	253	35371	5825	63447573
Eye pain	523.21	12.28	291	35333	33563	63419835
Glaucoma	516.80	12.28	239	35385	18666	63434732
Ocular hyperaemia	472.07	12.28	246	35378	24898	63428500
Visual acuity reduced	225.86	12.28	145	35479	21681	63431717
Eye pruritus	180.81	12.28	119	35505	18552	63434846
Colitis microscopic	174.10	12.28	91	35533	9248	63444150
Vision blurred	161.39	12.28	227	35397	91697	63361701
Foreign body sensation in eyes	154.27	12.28	55	35569	2179	63451219
Product container issue	154.19	12.28	52	35572	1741	63451657
Cataract	137.83	12.28	165	35459	56888	63396510
Product quality issue	112.75	12.28	119	35505	35746	63417652
Thyroid disorder	103.41	12.28	78	35546	15084	63438314
Skin reaction	102.63	12.28	77	35547	14772	63438626
Diverticulitis	96.50	12.28	115	35509	39442	63413956
Blindness	92.43	12.28	85	35539	21614	63431784
Intraocular pressure test abnormal	92.26	12.28	21	35603	150	63453248
Maternal exposure during pregnancy	91.09	12.28	9	35615	220053	63233345
Dry eye	85.74	12.28	110	35514	40651	63412747
Eye discharge	85.14	12.28	49	35575	6014	63447384
Visual impairment	82.27	12.28	160	35464	84286	63369112
Reaction to preservatives	81.70	12.28	20	35604	202	63453196
Eye disorder	78.01	12.28	79	35545	22606	63430792
Glossodynia	74.85	12.28	7	35617	178869	63274529
Ocular discomfort	72.54	12.28	39	35585	4194	63449204
Lacrimation increased	71.22	12.28	72	35552	20559	63432839
Conjunctival hyperaemia	71.01	12.28	32	35592	2347	63451051
Corneal disorder	65.84	12.28	28	35596	1786	63451612
Eye swelling	65.81	12.28	74	35550	23844	63429554
Systemic lupus erythematosus	61.99	12.28	20	35604	208898	63244500
Infusion related reaction	60.69	12.28	31	35593	245490	63207908
Choroidal effusion	58.06	12.28	18	35606	458	63452940
Blepharitis	57.88	12.28	29	35595	2696	63450702
Corneal opacity	57.84	12.28	20	35604	723	63452675
Growth of eyelashes	56.99	12.28	15	35609	207	63453191
Ocular surface disease	56.12	12.28	11	35613	33	63453365
Joint swelling	53.59	12.28	63	35561	327603	63125795
Toxic epidermal necrolysis	52.69	12.28	68	35556	25266	63428132
Visual field defect	52.08	12.28	37	35587	6524	63446874
Toxicity to various agents	51.67	12.28	38	35586	247212	63206186
Pericarditis	50.40	12.28	7	35617	131572	63321826
Product packaging quantity issue	49.40	12.28	21	35603	1338	63452060
Product delivery mechanism issue	49.33	12.28	15	35609	357	63453041
Arthropathy	49.17	12.28	36	35588	234756	63218642
Intraocular pressure fluctuation	48.40	12.28	10	35614	42	63453356
Corneal oedema	47.50	12.28	21	35603	1472	63451926
Contraindicated product administered	47.38	12.28	32	35592	217616	63235782
Bronchitis	45.61	12.28	164	35460	124771	63328627
Product packaging issue	45.05	12.28	19	35605	1187	63452211
Abnormal sensation in eye	44.32	12.28	21	35603	1728	63451670
Iridocyclitis	42.55	12.28	23	35601	2499	63450899
Trabeculectomy	41.88	12.28	8	35616	20	63453378
Eyelid margin crusting	40.41	12.28	17	35607	1055	63452343
Intraocular pressure decreased	39.75	12.28	10	35614	114	63453284
Blepharal pigmentation	39.70	12.28	9	35615	63	63453335
Erythema of eyelid	39.00	12.28	21	35603	2265	63451133
Normal tension glaucoma	38.64	12.28	8	35616	34	63453364
Infection	38.59	12.28	43	35581	229130	63224268
Hypersensitivity	38.22	12.28	288	35336	292397	63161001
Eye allergy	38.19	12.28	16	35608	983	63452415
Iris hyperpigmentation	38.09	12.28	8	35616	37	63453361
Iris atrophy	38.00	12.28	9	35615	78	63453320
Abdominal discomfort	36.95	12.28	78	35546	320807	63132591
Pain	36.89	12.28	254	35370	740374	62713024
Angle closure glaucoma	36.78	12.28	20	35604	2199	63451199
Product packaging difficult to open	36.49	12.28	9	35615	94	63453304
Burns second degree	36.08	12.28	19	35605	1959	63451439
Eye colour change	35.40	12.28	11	35613	282	63453116
Corneal deposits	35.22	12.28	11	35613	287	63453111
Discomfort	34.59	12.28	26	35598	167348	63286050
Product administration error	34.44	12.28	52	35572	22345	63431053
Macular oedema	33.42	12.28	23	35601	3854	63449544
Product use issue	33.31	12.28	45	35579	220475	63232923
Eyelash thickening	33.04	12.28	6	35618	10	63453388
Product container seal issue	32.34	12.28	9	35615	155	63453243
Lower respiratory tract infection	32.23	12.28	17	35607	132290	63321108
Conjunctival scar	31.81	12.28	7	35617	42	63453356
Dental restoration failure	31.78	12.28	14	35610	973	63452425
Eyelid oedema	31.56	12.28	34	35590	10445	63442953
Fall	31.27	12.28	347	35277	391987	63061411
Arthralgia	31.06	12.28	190	35434	569520	62883878
Corneal neovascularisation	30.49	12.28	8	35616	109	63453289
Transient ischaemic attack	30.22	12.28	66	35558	37687	63415711
Angioplasty	30.11	12.28	15	35609	1377	63452021
Iris adhesions	30.05	12.28	10	35614	321	63453077
Exposure during pregnancy	29.85	12.28	26	35598	155521	63297877
Blindness unilateral	29.63	12.28	26	35598	6215	63447183
Product use complaint	29.52	12.28	18	35606	2456	63450942
Choroidal detachment	29.33	12.28	9	35615	221	63453177
Procollagen type I C-terminal propeptide increased	29.27	12.28	6	35618	24	63453374
Febrile neutropenia	29.17	12.28	15	35609	118434	63334964
Intestinal polyp	28.73	12.28	15	35609	1520	63451878
Catarrh	28.60	12.28	15	35609	1534	63451864
Serum procollagen type I N-terminal propeptide increased	28.53	12.28	6	35618	28	63453370
Psoriatic arthropathy	28.51	12.28	8	35616	91512	63361886
Cystoid macular oedema	28.36	12.28	15	35609	1560	63451838
Rheumatoid arthritis	28.12	12.28	63	35561	253756	63199642
Poor quality product administered	27.86	12.28	19	35605	3137	63450261
Cerebrovascular accident	27.61	12.28	127	35497	107897	63345501
Alopecia	27.61	12.28	97	35527	337439	63115959
Photophobia	27.19	12.28	41	35583	17594	63435804
Hyphaema	27.01	12.28	9	35615	290	63453108
Thyroxine decreased	26.79	12.28	11	35613	642	63452756
Steroid dependence	26.77	12.28	15	35609	1749	63451649
Metamorphopsia	26.55	12.28	13	35611	1150	63452248
Cataract operation	26.21	12.28	23	35601	5499	63447899
Phlebitis	26.06	12.28	25	35599	6699	63446699
Conjunctivitis allergic	26	12.28	12	35612	930	63452468
Nasal discharge discolouration	25.76	12.28	16	35608	2255	63451143
Ill-defined disorder	25.74	12.28	7	35617	81748	63371650
Therapeutic product effect decreased	25.70	12.28	43	35581	193144	63260254
Instillation site irritation	25.46	12.28	7	35617	115	63453283
Eye operation	25.12	12.28	16	35608	2356	63451042
Purpura senile	24.87	12.28	10	35614	553	63452845
Product package associated injury	24.81	12.28	5	35619	18	63453380
Tarsal tunnel syndrome	24.68	12.28	10	35614	564	63452834
Product formulation issue	24.61	12.28	10	35614	568	63452830
Duodenal ulcer haemorrhage	24.55	12.28	16	35608	2451	63450947
Peripheral vascular disorder	24.45	12.28	23	35601	6012	63447386
Limb injury	24.45	12.28	48	35576	25429	63427969
Product substitution issue	24.39	12.28	37	35587	15959	63437439
Irritable bowel syndrome	24.23	12.28	8	35616	82404	63370994
Hyperaesthesia	24.13	12.28	28	35596	9330	63444068
Foreign body in eye	23.99	12.28	7	35617	144	63453254
Eye inflammation	23.97	12.28	22	35602	5577	63447821
Punctate keratitis	23.92	12.28	10	35614	611	63452787
Gastrointestinal disorder	23.91	12.28	23	35601	131216	63322182
Hypotony of eye	23.76	12.28	7	35617	149	63453249
Musculoskeletal stiffness	23.73	12.28	42	35582	184576	63268822
Liver injury	23.69	12.28	3	35621	60517	63392881
Thermal burns of eye	23.59	12.28	7	35617	153	63453245
Product storage error	23.39	12.28	35	35589	14921	63438477
Instillation site pain	23.35	12.28	11	35613	893	63452505
Maculopathy	23.32	12.28	15	35609	2247	63451151
Eye oedema	23.27	12.28	13	35611	1507	63451891
Meniscus injury	23.05	12.28	24	35600	7090	63446308
Product complaint	22.99	12.28	32	35592	12777	63440621
Choking	22.90	12.28	28	35596	9851	63443547
Retinal detachment	22.77	12.28	22	35602	5947	63447451
Chronotropic incompetence	22.72	12.28	6	35618	84	63453314
Body height decreased	22.45	12.28	28	35596	10050	63443348
Instillation site erythema	22.15	12.28	6	35618	93	63453305
Haemorrhage intracranial	21.84	12.28	32	35592	13387	63440011
Corneal epithelium defect	21.81	12.28	8	35616	344	63453054
Eyelid irritation	21.78	12.28	9	35615	534	63452864
Suicide attempt	21.61	12.28	4	35620	60914	63392484
Off label use	21.42	12.28	259	35365	674203	62779195
Pupillary disorder	21.20	12.28	7	35617	219	63453179
Pyrexia	21.11	12.28	166	35458	470312	62983086
Retinopathy haemorrhagic	20.94	12.28	4	35620	10	63453388
Floppy iris syndrome	20.91	12.28	6	35618	116	63453282
Eyelid disorder	20.91	12.28	13	35611	1836	63451562
Product dose omission issue	20.85	12.28	212	35412	234101	63219297
Conjunctival erosion	20.81	12.28	6	35618	118	63453280
Eye complication associated with device	20.41	12.28	4	35620	12	63453386
Hypopnoea	20.41	12.28	17	35607	3789	63449609
Cardiac failure congestive	20.26	12.28	104	35520	92329	63361069
Conjunctival follicles	20.16	12.28	4	35620	13	63453385
Swelling	20.01	12.28	83	35541	275295	63178103
Conjunctivitis	19.74	12.28	39	35585	20757	63432641
Iris hypopigmentation	19.52	12.28	4	35620	16	63453382
Photocoagulation	19.46	12.28	3	35621	0	63453398
Scleral hyperaemia	19.29	12.28	7	35617	292	63453106
Injury corneal	18.67	12.28	5	35619	74	63453324
Hyponatraemia	18.65	12.28	117	35507	111783	63341615
Expired product administered	18.51	12.28	20	35604	6161	63447237
Blood albumin abnormal	18.51	12.28	8	35616	531	63452867
Visual field tests abnormal	18.32	12.28	4	35620	23	63453375
Macular hole	18.06	12.28	9	35615	827	63452571
Symblepharon	17.97	12.28	5	35619	86	63453312
Retinal vascular disorder	17.96	12.28	6	35618	195	63453203
Hypoacusis	17.95	12.28	41	35583	24110	63429288
Glaucoma surgery	17.87	12.28	5	35619	88	63453310
Corneal degeneration	17.76	12.28	5	35619	90	63453308
Keratitis	17.76	12.28	15	35609	3407	63449991
Dysgeusia	17.61	12.28	62	35562	46648	63406750
Multiple organ dysfunction syndrome	17.60	12.28	5	35619	56747	63396651
Dacryostenosis acquired	17.57	12.28	8	35616	601	63452797
Product design issue	17.38	12.28	3	35621	3	63453395
Tubulointerstitial nephritis	17.31	12.28	36	35588	19867	63433531
Vitreous haemorrhage	17.29	12.28	12	35612	2038	63451360
Blister	17.16	12.28	29	35595	129785	63323613
Adenocarcinoma metastatic	17.13	12.28	5	35619	103	63453295
Epigastric discomfort	17	12.28	20	35604	6760	63446638
Retinal tear	16.95	12.28	10	35614	1284	63452114
Atrial flutter	16.92	12.28	24	35600	9748	63443650
Wound	16.89	12.28	42	35582	163221	63290177
Periorbital disorder	16.86	12.28	4	35620	35	63453363
Parosmia	16.72	12.28	19	35605	6187	63447211
Genital erythema	16.66	12.28	4	35620	37	63453361
Iritis	16.65	12.28	14	35610	3161	63450237
Hypertension	16.61	12.28	234	35390	279069	63174329
Corneal striae	16.52	12.28	3	35621	5	63453393
Incorrect dose administered	16.44	12.28	72	35552	59896	63393502
Ophthalmic herpes simplex	16.36	12.28	7	35617	453	63452945
Ocular hypertension	16.13	12.28	9	35615	1041	63452357
Instillation site reaction	16.05	12.28	7	35617	475	63452923
Palpitations	15.84	12.28	113	35511	112657	63340741
Reaction to excipient	15.82	12.28	10	35614	1454	63451944
Pulmonary congestion	15.74	12.28	32	35592	17386	63436012
Vitreous floaters	15.63	12.28	18	35606	5948	63447450
Eyelids pruritus	15.42	12.28	9	35615	1133	63452265
Achromotrichia acquired	15.31	12.28	3	35621	9	63453389
Subacute kidney injury	15.31	12.28	3	35621	9	63453389
Pharyngeal enanthema	15.21	12.28	4	35620	55	63453343
Liquid product physical issue	15.14	12.28	9	35615	1173	63452225
Corectopia	15.07	12.28	3	35621	10	63453388
Chronic leukaemia	15.07	12.28	3	35621	10	63453388
Keratitis interstitial	15.07	12.28	3	35621	10	63453388
Genital rash	14.99	12.28	7	35617	557	63452841
Stomatitis	14.89	12.28	35	35589	138690	63314708
Repetitive strain injury	14.86	12.28	5	35619	166	63453232
Fasciitis	14.78	12.28	7	35617	575	63452823
Resorption bone increased	14.51	12.28	9	35615	1265	63452133
Impaired healing	14.40	12.28	22	35602	102520	63350878
Haemorrhage	14.32	12.28	70	35554	60952	63392446
Ulcerative keratitis	14.31	12.28	12	35612	2698	63450700
Herpes ophthalmic	14.29	12.28	9	35615	1300	63452098
Product lot number issue	14.27	12.28	5	35619	188	63453210
Circumstance or information capable of leading to medication error	14.27	12.28	14	35610	3856	63449542
Glare	14.11	12.28	4	35620	74	63453324
Gingival pain	14.07	12.28	20	35604	8142	63445256
Tremor	13.91	12.28	124	35500	132115	63321283
Syncope	13.89	12.28	113	35511	117272	63336126
Chondropathy	13.86	12.28	11	35613	2289	63451109
Splenic haemorrhage	13.84	12.28	5	35619	206	63453192
Diabetic ulcer	13.74	12.28	5	35619	210	63453188
Uveitis	13.72	12.28	25	35599	12528	63440870
Hip fracture	13.69	12.28	42	35582	29432	63423966
Product closure removal difficult	13.63	12.28	3	35621	18	63453380
Vestibular disorder	13.55	12.28	9	35615	1422	63451976
Conjunctival oedema	13.54	12.28	7	35617	695	63452703
Eye haemorrhage	13.45	12.28	20	35604	8476	63444922
Sinus disorder	13.34	12.28	37	35587	24516	63428882
Rash	13.33	12.28	228	35396	560643	62892755
Injection site swelling	13.33	12.28	5	35619	47567	63405831
Injury	13.15	12.28	13	35611	73234	63380164
Ocular pemphigoid	13.12	12.28	4	35620	96	63453302
Type 2 diabetes mellitus	13.08	12.28	10	35614	63858	63389540
Superficial injury of eye	13.03	12.28	5	35619	244	63453154
Corneal abrasion	12.96	12.28	8	35616	1116	63452282
Crepitations	12.83	12.28	19	35605	8021	63445377
Corneal scar	12.64	12.28	4	35620	109	63453289
Weight increased	12.63	12.28	90	35534	260702	63192696
Injection site erythema	12.51	12.28	17	35607	83157	63370241
Cardiac amyloidosis	12.50	12.28	7	35617	815	63452583
Drug hypersensitivity	12.44	12.28	244	35380	310443	63142955
Paternal exposure during pregnancy	12.37	12.28	4	35620	117	63453281
Tinnitus	12.34	12.28	46	35578	35582	63417816
Laser therapy	12.28	12.28	3	35621	30	63453368

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Treatment failure	1037.11	12.65	521	20394	46176	34889840
Intraocular pressure increased	751.93	12.65	229	20686	5154	34930862
Eye irritation	570.84	12.65	202	20713	7359	34928657
Eye pain	217.94	12.65	122	20793	13340	34922676
Ocular hyperaemia	202.46	12.65	110	20805	11342	34924674
Visual acuity reduced	189.75	12.65	119	20796	16030	34919986
Glaucoma	173.23	12.65	84	20831	6828	34929188
Vision blurred	135.75	12.65	152	20763	45811	34890205
Foreign body sensation in eyes	114.78	12.65	33	20882	601	34935415
Product delivery mechanism issue	107.53	12.65	24	20891	144	34935872
Cataract	92.04	12.65	95	20820	26091	34909925
Corneal oedema	90.24	12.65	33	20882	1318	34934698
Corneal disorder	86.11	12.65	29	20886	905	34935111
Visual impairment	78.76	12.65	102	20813	35700	34900316
Product container issue	77.01	12.65	25	20890	694	34935322
Eye pruritus	75.14	12.65	50	20865	7439	34928577
Choroidal effusion	67.99	12.65	17	20898	176	34935840
Cystoid macular oedema	65.12	12.65	22	20893	693	34935323
Cataract operation	62.70	12.65	25	20890	1267	34934749
Corneal opacity	57.22	12.65	19	20896	567	34935449
Lacrimation increased	51.87	12.65	42	20873	8440	34927576
Blindness unilateral	49.65	12.65	32	20883	4510	34931506
Choroidal detachment	46.52	12.65	15	20900	407	34935609
Hypotony of eye	45.18	12.65	11	20904	101	34935915
Intraocular pressure fluctuation	44.90	12.65	8	20907	10	34936006
Anterior chamber disorder	43.85	12.65	10	20905	67	34935949
Eye disorder	43.66	12.65	40	20875	9488	34926528
Blindness	43.22	12.65	49	20866	14937	34921079
Product quality issue	42.97	12.65	52	20863	16983	34919033
Conjunctival hyperaemia	42.22	12.65	23	20892	2379	34933637
Hyphaema	41.67	12.65	15	20900	572	34935444
Dry eye	41.56	12.65	39	20876	9536	34926480
Completed suicide	41.49	12.65	5	20910	98163	34837853
Blepharitis	40.58	12.65	19	20896	1426	34934590
Eye discharge	40.31	12.65	21	20894	1985	34934031
Intraocular pressure test abnormal	38.41	12.65	9	20906	69	34935947
Iridocyclitis	38.16	12.65	19	20896	1633	34934383
Angle closure glaucoma	37.86	12.65	16	20899	941	34935075
Product packaging quantity issue	34.99	12.65	15	20900	914	34935102
Keratitis	34.44	12.65	17	20898	1434	34934582
Ectropion	34.19	12.65	9	20906	116	34935900
Thermal burns of eye	33.90	12.65	6	20909	7	34936009
Macular oedema	33.01	12.65	21	20894	2893	34933123
Ocular surface disease	33	12.65	8	20907	72	34935944
Conjunctival oedema	32.98	12.65	12	20903	472	34935544
Toxicity to various agents	32.93	12.65	43	20872	200319	34735697
Corneal infiltrates	31.93	12.65	9	20906	152	34935864
Corneal neovascularisation	31.22	12.65	7	20908	43	34935973
Growth of eyelashes	30.99	12.65	8	20907	95	34935921
Herpes ophthalmic	30.71	12.65	12	20903	576	34935440
Ocular hypertension	29.74	12.65	13	20902	831	34935185
Trabeculoplasty	29.17	12.65	5	20910	4	34936012
Visual field defect	29.12	12.65	23	20892	4460	34931556
Intraocular pressure decreased	28.58	12.65	7	20908	66	34935950
Reaction to preservatives	28.21	12.65	7	20908	70	34935946
Punctate keratitis	27.99	12.65	10	20905	373	34935643
Photocoagulation	27.74	12.65	5	20910	7	34936009
Eyelid margin crusting	27.71	12.65	9	20906	250	34935766
Eye inflammation	27.69	12.65	17	20898	2201	34933815
Instillation site pain	26.54	12.65	7	20908	91	34935925
Ulcerative keratitis	26.15	12.65	15	20900	1714	34934302
Ocular discomfort	25.73	12.65	16	20899	2118	34933898
Ophthalmic herpes simplex	25.58	12.65	9	20906	321	34935695
Pyelitis	25.25	12.65	7	20908	111	34935905
Erythema of eyelid	25.23	12.65	12	20903	933	34935083
Glaucoma surgery	25.19	12.65	5	20910	15	34936001
Eyelid irritation	24.91	12.65	7	20908	117	34935899
Product substitution issue	24.14	12.65	30	20885	10065	34925951
Product formulation issue	24.13	12.65	10	20905	560	34935456
Trabeculectomy	23.88	12.65	5	20910	21	34935995
Glaucomatous optic disc atrophy	23.45	12.65	4	20911	3	34936013
Burns second degree	23.21	12.65	12	20903	1117	34934899
Open angle glaucoma	22.97	12.65	7	20908	157	34935859
Dizziness	22.86	12.65	215	20700	218306	34717710
Eyelids pruritus	22.45	12.65	7	20908	170	34935846
Uveitis	22.34	12.65	25	20890	7510	34928506
Product container seal issue	22.03	12.65	4	20911	6	34936010
Hypersensitivity	21.72	12.65	83	20832	60952	34875064
Catarrh	21.61	12.65	11	20904	991	34935025
Parosmia	21.49	12.65	15	20900	2410	34933606
Eye swelling	21.22	12.65	28	20887	9967	34926049
Macular cyst	20.98	12.65	4	20911	9	34936007
Product use complaint	20.53	12.65	12	20903	1420	34934596
Photophobia	20.47	12.65	23	20892	6941	34929075
Instillation site erythema	20.41	12.65	4	20911	11	34936005
Visual acuity tests abnormal	20.24	12.65	5	20910	49	34935967
Optic nerve injury	20.02	12.65	6	20909	127	34935889
Steroid dependence	19.89	12.65	12	20903	1505	34934511
Bone marrow oedema	19.38	12.65	9	20906	663	34935353
Prostaglandin analogue periorbitopathy	19.27	12.65	3	20912	0	34936016
Iris hyperpigmentation	19.27	12.65	3	20912	0	34936016
Vitreous adhesions	19.26	12.65	4	20911	16	34936000
Corneal scar	18.89	12.65	6	20909	155	34935861
Off label use	18.26	12.65	162	20753	419362	34516654
Fall	18.01	12.65	193	20722	202692	34733324
Heart rate abnormal	17.82	12.65	12	20903	1819	34934197
Conjunctival disorder	17.82	12.65	5	20910	83	34935933
Hypopnoea	17.63	12.65	13	20902	2276	34933740
Corneal erosion	17.29	12.65	5	20910	93	34935923
Asthenopia	17.27	12.65	8	20907	586	34935430
Vitreous haemorrhage	17.21	12.65	13	20902	2360	34933656
Vitreous disorder	17.14	12.65	5	20910	96	34935920
Bronchiectasis	17.12	12.65	25	20890	9776	34926240
Eyelid ptosis	16.87	12.65	19	20896	5747	34930269
Drug interaction	16.68	12.65	74	20841	225872	34710144
Multiple organ dysfunction syndrome	16.46	12.65	13	20902	76553	34859463
Gingival pain	16.35	12.65	14	20901	3038	34932978
Corneal bleeding	15.97	12.65	3	20912	6	34936010
Eye haemorrhage	15.80	12.65	16	20899	4289	34931727
Tinnitus	15.49	12.65	36	20879	20082	34915934
Anterior chamber inflammation	15.39	12.65	6	20909	286	34935730
Funguria	14.89	12.65	4	20911	56	34935960
Choluria	14.61	12.65	5	20910	164	34935852
Optic nerve cupping	14.51	12.65	4	20911	62	34935954
Conjunctivitis	14.47	12.65	23	20892	9682	34926334
Myoclonic dystonia	14.34	12.65	4	20911	65	34935951
Suicide attempt	14.25	12.65	3	20912	39113	34896903
Scleral hyperaemia	14.17	12.65	4	20911	68	34935948
Diplopia	13.92	12.65	31	20884	16812	34919204
Keratopathy	13.67	12.65	7	20908	638	34935378
Eye laser surgery	13.59	12.65	3	20912	17	34935999
Product packaging issue	13.58	12.65	7	20908	647	34935369
Macular hole	13.36	12.65	5	20910	213	34935803
Swollen tongue	13.35	12.65	28	20887	14577	34921439
Keratitis interstitial	13.17	12.65	3	20912	20	34935996
Iris atrophy	13.07	12.65	4	20911	91	34935925
Iritis	12.97	12.65	9	20906	1432	34934584
Scleral disorder	12.92	12.65	3	20912	22	34935994
Corneal infection	12.69	12.65	3	20912	24	34935992

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Intraocular pressure increased	952.05	11.33	303	42235	8902	79692948
Eye irritation	841.32	11.33	341	42197	20340	79681510
Glaucoma	483.99	11.33	228	42310	19533	79682317
Eye pain	354.23	11.33	231	42307	37347	79664503
Visual acuity reduced	327.35	11.33	201	42337	29268	79672582
Ocular hyperaemia	314.88	11.33	193	42345	28013	79673837
Cataract	159.71	11.33	181	42357	61939	79639911
Vision blurred	155.44	11.33	234	42304	105664	79596186
Colitis microscopic	136.52	11.33	80	42458	10688	79691162
Corneal oedema	116.14	11.33	46	42492	2574	79699276
Foreign body sensation in eyes	113.87	11.33	43	42495	2114	79699736
Corneal disorder	107.80	11.33	42	42496	2249	79699601
Completed suicide	106.78	11.33	6	42532	245761	79456089
Blindness	104.01	11.33	100	42438	28283	79673567
Choroidal effusion	98.56	11.33	29	42509	648	79701202
Eye pruritus	93.96	11.33	82	42456	20488	79681362
Ocular surface disease	83.13	11.33	18	42520	105	79701745
Corneal opacity	82.90	11.33	28	42510	992	79700858
Visual impairment	81.73	11.33	163	42375	91968	79609882
Cystoid macular oedema	81.65	11.33	33	42505	1947	79699903
Product quality issue	80.66	11.33	95	42443	33845	79668005
Product delivery mechanism issue	76.71	11.33	18	42520	158	79701692
Diverticulitis	75.30	11.33	107	42431	45829	79656021
Angle closure glaucoma	74.86	11.33	35	42503	2941	79698909
Thyroid disorder	74.32	11.33	61	42477	14018	79687832
Visual field defect	74.11	11.33	51	42487	8994	79692856
Skin reaction	73.28	11.33	64	42474	16004	79685846
Blepharitis	73.24	11.33	35	42503	3089	79698761
Conjunctival hyperaemia	72.86	11.33	39	42499	4374	79697476
Toxicity to various agents	71.14	11.33	72	42466	421468	79280382
Intraocular pressure test abnormal	69.61	11.33	16	42522	127	79701723
Choroidal detachment	65.98	11.33	21	42517	615	79701235
Lacrimation increased	65.54	11.33	70	42468	22407	79679443
Trabeculectomy	65.34	11.33	13	42525	46	79701804
Iridocyclitis	61.90	11.33	33	42505	3671	79698179
Eye discharge	61.52	11.33	39	42499	5995	79695855
Intraocular pressure fluctuation	57.14	11.33	12	42526	59	79701791
Eye disorder	56.40	11.33	66	42472	23346	79678504
Reaction to preservatives	56.40	11.33	15	42523	228	79701622
Intraocular pressure decreased	55.70	11.33	14	42524	168	79701682
Burns second degree	54.28	11.33	27	42511	2601	79699249
Bronchitis	47.88	11.33	166	42372	130478	79571372
Corneal neovascularisation	47.14	11.33	12	42526	152	79701698
Fall	47.11	11.33	431	42107	487198	79214652
Blindness unilateral	46.61	11.33	37	42501	8109	79693741
Product formulation issue	46.37	11.33	18	42520	954	79700896
Hypotony of eye	46.27	11.33	13	42525	245	79701605
Maternal exposure during pregnancy	45.06	11.33	9	42529	136529	79565321
Product container issue	44.72	11.33	19	42519	1272	79700578
Hyphaema	44.05	11.33	17	42521	887	79700963
Infusion related reaction	43.97	11.33	35	42503	230202	79471648
Catarrh	43.87	11.33	22	42516	2156	79699694
Steroid dependence	42.74	11.33	23	42515	2607	79699243
Punctate keratitis	42.62	11.33	17	42521	969	79700881
Eye swelling	42.41	11.33	61	42477	26407	79675443
Iris atrophy	42.40	11.33	11	42527	151	79701699
Keratitis	41.75	11.33	27	42511	4295	79697555
Photocoagulation	40.91	11.33	7	42531	7	79701843
Eye inflammation	40.76	11.33	31	42507	6382	79695468
Iris hyperpigmentation	40.73	11.33	8	42530	26	79701824
Ulcerative keratitis	40.52	11.33	25	42513	3664	79698186
Dry eye	39.76	11.33	71	42467	36860	79664990
Instillation site pain	36.67	11.33	14	42524	709	79701141
Ophthalmic herpes simplex	36.54	11.33	14	42524	716	79701134
Pericarditis	36.27	11.33	6	42532	104230	79597620
Macular oedema	35.98	11.33	27	42511	5447	79696403
Instillation site erythema	34.64	11.33	8	42530	65	79701785
Infection	34.58	11.33	47	42491	241665	79460185
Hypopnoea	34.40	11.33	26	42512	5303	79696547
Corneal deposits	33.99	11.33	12	42526	486	79701364
Ocular discomfort	33.70	11.33	25	42513	4958	79696892
Conjunctival oedema	33.47	11.33	15	42523	1143	79700707
Anterior chamber disorder	32.90	11.33	9	42529	153	79701697
Cataract operation	32.81	11.33	25	42513	5160	79696690
Dental restoration failure	32.50	11.33	14	42524	970	79700880
Corneal scar	31.25	11.33	10	42528	298	79701552
Growth of eyelashes	31.11	11.33	9	42529	189	79701661
Thermal burns of eye	31.03	11.33	8	42530	107	79701743
Intestinal polyp	30.33	11.33	17	42521	2087	79699763
Parosmia	30.11	11.33	27	42511	6987	79694863
Normal tension glaucoma	30.08	11.33	7	42531	59	79701791
Product substitution issue	30.02	11.33	45	42493	20211	79681639
Procollagen type I C-terminal propeptide increased	29.58	11.33	6	42532	24	79701826
Angioplasty	29.46	11.33	16	42522	1847	79700003
Iris adhesions	29.24	11.33	11	42527	535	79701315
Dacryostenosis acquired	29.12	11.33	11	42527	541	79701309
Abnormal sensation in eye	28.89	11.33	16	42522	1919	79699931
Instillation site irritation	28.83	11.33	7	42531	72	79701778
Transient ischaemic attack	28.73	11.33	77	42461	52618	79649232
Serum procollagen type I N-terminal propeptide increased	28.66	11.33	6	42532	29	79701821
Glossodynia	28.08	11.33	10	42528	103327	79598523
Multiple organ dysfunction syndrome	27.38	11.33	15	42523	120231	79581619
Febrile neutropenia	27.29	11.33	51	42487	230948	79470902
Visual field tests abnormal	27.20	11.33	5	42533	10	79701840
Erythema of eyelid	27.18	11.33	17	42521	2553	79699297
Corneal infiltrates	27.14	11.33	9	42529	301	79701549
Hyperaesthesia	27.04	11.33	33	42505	12189	79689661
Ocular hypertension	26.70	11.33	14	42524	1506	79700344
Joint swelling	26.57	11.33	73	42465	288573	79413277
Blepharal pigmentation	26.40	11.33	6	42532	45	79701805
Eyelid ptosis	26.38	11.33	31	42507	11013	79690837
Glaucoma surgery	26.28	11.33	7	42531	107	79701743
Product complaint	26.28	11.33	34	42504	13315	79688535
Suicide attempt	26.27	11.33	6	42532	82926	79618924
Poor quality product administered	26.26	11.33	19	42519	3626	79698224
Gingival pain	26.19	11.33	28	42510	8970	79692880
Dizziness	26.18	11.33	410	42128	526031	79175819
Vitreous haemorrhage	25.94	11.33	19	42519	3694	79698156
Floppy iris syndrome	25.75	11.33	9	42529	354	79701496
Maculopathy	25.70	11.33	17	42521	2808	79699042
Conjunctival follicles	25.52	11.33	5	42533	16	79701834
Eye oedema	25.29	11.33	15	42523	2048	79699802
Toxic epidermal necrolysis	25.17	11.33	66	42472	44515	79657335
Cerebrovascular accident	25.01	11.33	155	42383	155137	79546713
Nasal discharge discolouration	24.97	11.33	16	42522	2505	79699345
Duodenal ulcer perforation	24.93	11.33	3	42535	66208	79635642
Macular hole	24.90	11.33	11	42527	810	79701040
Mucosal inflammation	24.90	11.33	5	42533	75575	79626275
Limb injury	24.69	11.33	51	42487	29477	79672373
Thyroxine decreased	24.25	11.33	11	42527	862	79700988
Photophobia	24.09	11.33	41	42497	20487	79681363
Psoriatic arthropathy	24.00	11.33	6	42532	77993	79623857
Herpes ophthalmic	23.99	11.33	13	42525	1494	79700356
Open angle glaucoma	23.92	11.33	9	42529	438	79701412
Glaucomatous optic disc atrophy	23.91	11.33	4	42534	3	79701847
Keratitis interstitial	23.91	11.33	5	42533	24	79701826
Cornea verticillata	23.48	11.33	7	42531	164	79701686
Arrhythmia	23.43	11.33	79	42459	61193	79640657
Phlebitis	23.13	11.33	26	42512	8804	79693046
Corneal epithelium defect	22.99	11.33	10	42528	709	79701141
Metamorphopsia	22.97	11.33	12	42526	1281	79700569
Hyponatraemia	22.94	11.33	168	42370	177680	79524170
Arthralgia	22.92	11.33	195	42343	571608	79130242
Purpura senile	22.43	11.33	9	42529	521	79701329
Chronotropic incompetence	22.39	11.33	6	42532	94	79701756
Conjunctivitis allergic	22.38	11.33	13	42525	1707	79700143
Tarsal tunnel syndrome	22.33	11.33	9	42529	527	79701323
Eyelid margin crusting	22.23	11.33	11	42527	1048	79700802
Retinal detachment	22.16	11.33	26	42512	9221	79692629
Arthropathy	21.91	11.33	38	42500	177073	79524777
Uveitis	21.61	11.33	35	42503	16795	79685055
Heart rate abnormal	21.54	11.33	21	42517	6036	79695814
Sinus disorder	21.43	11.33	41	42497	22423	79679427
Meniscus injury	21.37	11.33	22	42516	6746	79695104
Conjunctivitis	21.01	11.33	44	42494	25671	79676179
Keratopathy	20.98	11.33	11	42527	1183	79700667
Eyelid disorder	20.70	11.33	13	42525	1965	79699885
Corneal degeneration	20.35	11.33	6	42532	135	79701715
Epigastric discomfort	20.26	11.33	23	42515	7873	79693977
Muscular weakness	20.25	11.33	151	42387	160578	79541272
Product use issue	20.11	11.33	52	42486	209770	79492080
Swollen tongue	20.06	11.33	59	42479	42511	79659339
Tubulointerstitial nephritis	19.97	11.33	55	42483	38180	79663670
Peripheral vascular disorder	19.95	11.33	23	42515	8007	79693843
Product packaging quantity issue	19.72	11.33	11	42527	1338	79700512
Eyelid oedema	19.70	11.33	30	42508	13657	79688193
Eye haemorrhage	19.44	11.33	25	42513	9732	79692118
Scleral hyperaemia	19.30	11.33	7	42531	307	79701543
Acute kidney injury	19.20	11.33	386	42152	519018	79182832
Atrial flutter	18.85	11.33	38	42500	21587	79680263
Pyelitis	18.69	11.33	7	42531	336	79701514
Meibomianitis	18.62	11.33	5	42533	79	79701771
Off label use	18.52	11.33	357	42181	906858	78794992
Gastrointestinal disorder	18.25	11.33	23	42515	122182	79579668
Choking	18.10	11.33	27	42511	12074	79689776
Cardiac failure congestive	18.06	11.33	134	42404	142268	79559582
Bronchiectasis	17.94	11.33	38	42500	22348	79679502
Conjunctival scar	17.80	11.33	6	42532	211	79701639
Cardiac murmur	17.77	11.33	31	42507	15793	79686057
Tinnitus	17.70	11.33	58	42480	44275	79657575
Contraindicated product administered	17.55	11.33	36	42502	157502	79544348
Eye colour change	17.46	11.33	7	42531	404	79701446
Body height decreased	17.12	11.33	22	42516	8558	79693292
Eye operation	17.01	11.33	12	42526	2201	79699649
Systemic lupus erythematosus	16.87	11.33	24	42514	121125	79580725
Rectal haemorrhage	16.87	11.33	83	42455	76217	79625633
Blood albumin abnormal	16.85	11.33	8	42530	696	79701154
Stomatitis	16.80	11.33	33	42505	146724	79555126
Atrioventricular block complete	16.69	11.33	31	42507	16579	79685271
Apathy	16.68	11.33	27	42511	12950	79688900
Lower respiratory tract infection	16.65	11.33	27	42511	129193	79572657
Rhinitis	16.62	11.33	29	42509	14778	79687072
Vertigo	16.61	11.33	77	42461	69005	79632845
Nightmare	16.39	11.33	40	42498	25821	79676029
Vitreous adhesions	16.15	11.33	4	42534	45	79701805
Product dose omission issue	15.98	11.33	202	42336	247335	79454515
Impaired quality of life	15.92	11.33	28	42510	14358	79687492
Macular cyst	15.84	11.33	4	42534	49	79701801
Ocular rosacea	15.72	11.33	3	42535	8	79701842
Repetitive strain injury	15.53	11.33	5	42533	152	79701698
Rheumatoid arthritis	15.48	11.33	58	42480	208412	79493438
Dysgeusia	15.46	11.33	66	42472	57111	79644739
Retinal tear	15.45	11.33	10	42528	1592	79700258
Asthma	15.39	11.33	124	42414	134971	79566879
Retinal vascular disorder	15.35	11.33	6	42532	324	79701526
Ill-defined disorder	15.31	11.33	8	42530	65867	79635983
Corectopia	15.22	11.33	3	42535	10	79701840
Overdose	15.20	11.33	49	42489	184157	79517693
Pharyngeal enanthema	15.15	11.33	4	42534	59	79701791
Iritis	14.91	11.33	14	42524	3841	79698009
Intraocular pressure test	14.91	11.33	4	42534	63	79701787
Retinal artery occlusion	14.78	11.33	13	42525	3281	79698569
Prostaglandin analogue periorbitopathy	14.60	11.33	3	42535	13	79701837
Discomfort	14.59	11.33	28	42510	125589	79576261
Adenocarcinoma metastatic	14.57	11.33	5	42533	186	79701664
Eyelids pruritus	14.56	11.33	8	42530	945	79700905
International normalised ratio increased	14.55	11.33	86	42452	84635	79617215
Myoclonic dystonia	14.51	11.33	4	42534	70	79701780
Paternal exposure during pregnancy	14.51	11.33	4	42534	70	79701780
Corneal lesion	14.41	11.33	4	42534	72	79701778
Palpitations	14.31	11.33	116	42422	126494	79575356
Retinopathy haemorrhagic	14.31	11.33	4	42534	74	79701776
Superficial injury of eye	14.30	11.33	5	42533	197	79701653
Ageusia	14.22	11.33	29	42509	16603	79685247
Subacute kidney injury	14.08	11.33	3	42535	16	79701834
Haemorrhage intracranial	14.00	11.33	38	42500	26155	79675695
Genital rash	13.99	11.33	8	42530	1020	79700830
Hypertension	13.93	11.33	251	42287	330741	79371109
Ectropion	13.84	11.33	6	42532	422	79701428
Irritable bowel syndrome	13.82	11.33	8	42530	62233	79639617
Pigmentation disorder	13.80	11.33	16	42522	5602	79696248
Achromotrichia acquired	13.78	11.33	3	42535	18	79701832
Corneal pigmentation	13.78	11.33	3	42535	18	79701832
Conjunctivochalasis	13.78	11.33	3	42535	18	79701832
Ascites	13.78	11.33	12	42526	75550	79626300
Injury corneal	13.74	11.33	4	42534	86	79701764
Duodenal ulcer haemorrhage	13.72	11.33	18	42520	7145	79694705
Resorption bone increased	13.72	11.33	9	42529	1466	79700384
Eye allergy	13.63	11.33	7	42531	721	79701129
Product container seal issue	13.57	11.33	4	42534	90	79701760
Injection site erythema	13.57	11.33	13	42525	78184	79623666
Pyrexia	13.54	11.33	268	42270	678441	79023409
Corneal striae	13.51	11.33	3	42535	20	79701830
Chondropathy	13.50	11.33	11	42527	2501	79699349
Corneal thickening	13.38	11.33	3	42535	21	79701829
Red blood cell sedimentation rate increased	13.26	11.33	4	42534	45938	79655912
Blood magnesium decreased	13.20	11.33	28	42510	16484	79685366
Pain	13.13	11.33	281	42257	703521	78998329
Diabetic ulcer	13.12	11.33	5	42533	252	79701598
Reaction to excipient	13.11	11.33	9	42529	1580	79700270
Corneal infection	13.06	11.33	4	42534	103	79701747
Vitreous disorder	13.05	11.33	5	42533	256	79701594
Hyperkalaemia	13.03	11.33	105	42433	114293	79587557
Liquid product physical issue	13.01	11.33	8	42530	1166	79700684
Septic shock	12.89	11.33	29	42509	122772	79579078
Musculoskeletal stiffness	12.79	11.33	49	42489	174959	79526891
Abdominal pain	12.57	11.33	140	42398	389429	79312421
Therapeutic product effect decreased	12.55	11.33	45	42493	163818	79538032
Visual acuity tests abnormal	12.54	11.33	4	42534	118	79701732
Hypoacusis	12.54	11.33	40	42498	30110	79671740
Bone marrow oedema	12.51	11.33	9	42529	1702	79700148
Hepatotoxicity	12.29	11.33	6	42532	51346	79650504
Brain stem haematoma	12.26	11.33	4	42534	127	79701723
Injury	12.19	11.33	14	42524	77482	79624368
Bone marrow failure	12.19	11.33	6	42532	51101	79650749
Anterior chamber inflammation	12.16	11.33	6	42532	568	79701282
Bradycardia	12.12	11.33	118	42420	135439	79566411
Endophthalmitis	12.08	11.33	16	42522	6412	79695438
Hip fracture	12.06	11.33	40	42498	30721	79671129
Intracranial haematoma	11.96	11.33	7	42531	933	79700917
Anterior chamber cell	11.89	11.33	7	42531	942	79700908
Cytomegalovirus infection	11.80	11.33	4	42534	42640	79659210
Blood calcium abnormal	11.78	11.33	8	42530	1381	79700469
Leiomyoma	11.74	11.33	5	42533	337	79701513
Eczema	11.73	11.33	48	42490	40770	79661080
Corneal transplant	11.67	11.33	5	42533	342	79701508
Abortion	11.67	11.33	8	42530	1402	79700448
Optic nerve injury	11.67	11.33	6	42532	620	79701230
Vestibular disorder	11.64	11.33	10	42528	2445	79699405
Hallucination	11.62	11.33	82	42456	85663	79616187
Noninfective conjunctivitis	11.58	11.33	3	42535	41	79701809
Instillation site reaction	11.56	11.33	5	42533	350	79701500
Oral mucosal discolouration	11.54	11.33	5	42533	351	79701499
Eyelid pain	11.52	11.33	5	42533	353	79701497
Keratic precipitates	11.45	11.33	5	42533	358	79701492
Device deposit issue	11.44	11.33	3	42535	43	79701807
Flat anterior chamber of eye	11.43	11.33	4	42534	158	79701692

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	S01EE01	SENSORY ORGANS OPHTHALMOLOGICALS ANTIGLAUCOMA PREPARATIONS AND MIOTICS Prostaglandin analogues
ATC	S01EE51	SENSORY ORGANS OPHTHALMOLOGICALS ANTIGLAUCOMA PREPARATIONS AND MIOTICS Prostaglandin analogues
FDA CS	M0017805	Prostaglandins
FDA EPC	N0000175454	Prostaglandin Analog
MeSH PA	D009883	Ophthalmic Solutions
MeSH PA	D019999	Pharmaceutical Solutions
CHEBI has role	CHEBI:23018	EC 4.2.1.1 inhibitor
CHEBI has role	CHEBI:35674	antihypertensive drugs
CHEBI has role	CHEBI:39456	antiglaucoma agent
CHEBI has role	CHEBI:50266	Prodrugs

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Ocular hypertension	indication	4210003	DOID:9282
Open-angle glaucoma	indication	84494001	DOID:1067
Conjunctivitis	contraindication	9826008	DOID:6195
Aphakia	contraindication	24010005
Macular retinal edema	contraindication	37231002	DOID:4449
Iritis	contraindication	65074000	DOID:1406
Pseudophakia	contraindication	95217000
Uveitis	contraindication	128473001	DOID:13141
Cystoid macular edema	contraindication	193387007	DOID:4447
Disorder of macula of retina	contraindication	312999006

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

Formulation strength	Trade name	Applicant	Application number	Approval date	Type	Dose form	Route	Patent number	Patent expiration date	Patent use
0.005%;EQ 0.02% BASE	ROCKLATAN	ALCON LABS INC	N208259	March 12, 2019	RX	SOLUTION/DROPS	OPHTHALMIC	10532993	July 11, 2026	REDUCTION OF ELEVATED INTRAOCULAR PRESSURE
0.005%;EQ 0.02% BASE	ROCKLATAN	ALCON LABS INC	N208259	March 12, 2019	RX	SOLUTION/DROPS	OPHTHALMIC	10882840	July 11, 2026	REDUCTION OF ELEVATED INTRAOCULAR PRESSURE
0.005%;EQ 0.02% BASE	ROCKLATAN	ALCON LABS INC	N208259	March 12, 2019	RX	SOLUTION/DROPS	OPHTHALMIC	11021456	July 11, 2026	REDUCTION OF ELEVATED INTRAOCULAR PRESSURE
0.005%;EQ 0.02% BASE	ROCKLATAN	ALCON LABS INC	N208259	March 12, 2019	RX	SOLUTION/DROPS	OPHTHALMIC	8450344	July 11, 2026	REDUCTION OF ELEVATED INTRAOCULAR PRESSURE
0.005%;EQ 0.02% BASE	ROCKLATAN	ALCON LABS INC	N208259	March 12, 2019	RX	SOLUTION/DROPS	OPHTHALMIC	9096569	July 11, 2026	REDUCTION OF ELEVATED INTRAOCULAR PRESSURE
0.005%	XELPROS	SUN PHARM	N206185	Sept. 12, 2018	RX	EMULSION	OPHTHALMIC	9539262	Oct. 15, 2028	REDUCING ELEVATED INTRAOCULAR PRESSURE IN PATIENTS WITH OPEN-ANGLE GLAUCOMA OR OCULAR HYPERTENSION
0.005%;EQ 0.02% BASE	ROCKLATAN	ALCON LABS INC	N208259	March 12, 2019	RX	SOLUTION/DROPS	OPHTHALMIC	10174017	Jan. 27, 2030	REDUCTION OF ELEVATED INTRAOCULAR PRESSURE
0.005%;EQ 0.02% BASE	ROCKLATAN	ALCON LABS INC	N208259	March 12, 2019	RX	SOLUTION/DROPS	OPHTHALMIC	10654844	Jan. 27, 2030	REDUCTION OF ELEVATED INTRAOCULAR PRESSURE
0.005%;EQ 0.02% BASE	ROCKLATAN	ALCON LABS INC	N208259	March 12, 2019	RX	SOLUTION/DROPS	OPHTHALMIC	11028081	Jan. 27, 2030	REDUCTION OF ELEVATED INTRAOCULAR PRESSURE
0.005%;EQ 0.02% BASE	ROCKLATAN	ALCON LABS INC	N208259	March 12, 2019	RX	SOLUTION/DROPS	OPHTHALMIC	11618748	Jan. 27, 2030	REDUCTION OF ELEVATED INTRAOCULAR PRESSURE
0.005%;EQ 0.02% BASE	ROCKLATAN	ALCON LABS INC	N208259	March 12, 2019	RX	SOLUTION/DROPS	OPHTHALMIC	8394826	Nov. 10, 2030	REDUCTION OF ELEVATED INTRAOCULAR PRESSURE
0.005%;EQ 0.02% BASE	ROCKLATAN	ALCON LABS INC	N208259	March 12, 2019	RX	SOLUTION/DROPS	OPHTHALMIC	10588901	March 14, 2034	REDUCTION OF ELEVATED INTRAOCULAR PRESSURE
0.005%;EQ 0.02% BASE	ROCKLATAN	ALCON LABS INC	N208259	March 12, 2019	RX	SOLUTION/DROPS	OPHTHALMIC	9931336	March 14, 2034	REDUCTION OF ELEVATED INTRAOCULAR PRESSURE
0.005%;EQ 0.02% BASE	ROCKLATAN	ALCON LABS INC	N208259	March 12, 2019	RX	SOLUTION/DROPS	OPHTHALMIC	9993470	March 14, 2034	REDUCTION OF ELEVATED INTRAOCULAR PRESSURE

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Prostaglandin F2-alpha receptor	GPCR	P43088	PF2R_HUMAN	AGONIST	Ki	6.30		IUPHAR	CHEMBL
Prostaglandin E2 receptor EP1 subtype	GPCR	P34995	PE2R1_HUMAN		Ki	5.76		PDSP
Prostaglandin E2 receptor EP3 subtype	GPCR	P43115	PE2R3_HUMAN		Ki	5.19		PDSP
Prostaglandin F2-alpha receptor	GPCR		PF2R_BOVIN		Ki	7.01		CHEMBL

External reference:

ID	Source
4020967	VUID
N0000148440	NUI
D00356	KEGG_DRUG
4020967	VANDF
C0090306	UMLSCUI
CHEBI:6384	CHEBI
CHEBI:63925	CHEBI
CHEMBL1051	ChEMBL_ID
D000077338	MESH_DESCRIPTOR_UI
DB00654	DRUGBANK_ID
5311221	PUBCHEM_CID
6980	INN_ID
6Z5B6HVF6O	UNII
153159	RXNORM
4959	MMSL
52442	MMSL
5860	MMSL
d04017	MMSL
006059	NDDF
108838001	SNOMEDCT_US
386926002	SNOMEDCT_US
CHEMBL1164123	ChEMBL_ID
CHEMBL1050	ChEMBL_ID
41639-83-2	SECONDARY_CAS_RN
6441636	PUBCHEM_CID
EJ85341990	UNII

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Xalatan	HUMAN PRESCRIPTION DRUG LABEL	1	0013-8303	SOLUTION	50 ug	OPHTHALMIC	NDA	26 sections
Xalatan	HUMAN PRESCRIPTION DRUG LABEL	1	0013-8303	SOLUTION	50 ug	OPHTHALMIC	NDA	26 sections
Xalatan	HUMAN PRESCRIPTION DRUG LABEL	1	0013-8303	SOLUTION	50 ug	OPHTHALMIC	NDA	26 sections
LATANOPROST	HUMAN PRESCRIPTION DRUG LABEL	1	17478-625	SOLUTION/ DROPS	50 ug	OPHTHALMIC	ANDA	25 sections
Latanoprost	HUMAN PRESCRIPTION DRUG LABEL	1	21695-986	SOLUTION/ DROPS	50 ug	OPHTHALMIC	ANDA	26 sections
Latanoprost	HUMAN PRESCRIPTION DRUG LABEL	1	24208-463	SOLUTION/ DROPS	50 ug	OPHTHALMIC	ANDA	24 sections
Latanoprost	HUMAN PRESCRIPTION DRUG LABEL	1	24208-463	SOLUTION/ DROPS	50 ug	OPHTHALMIC	ANDA	24 sections
Latanoprost	HUMAN PRESCRIPTION DRUG LABEL	1	24208-463	SOLUTION/ DROPS	50 ug	OPHTHALMIC	ANDA	24 sections
XELPROS	HUMAN PRESCRIPTION DRUG LABEL	1	47335-317	SOLUTION/ DROPS	0.05 mg	OPHTHALMIC	NDA	24 sections
XELPROS	HUMAN PRESCRIPTION DRUG LABEL	1	47335-317	SOLUTION/ DROPS	0.05 mg	OPHTHALMIC	NDA	24 sections
XELPROS	HUMAN PRESCRIPTION DRUG LABEL	1	47335-317	SOLUTION/ DROPS	0.05 mg	OPHTHALMIC	NDA	24 sections
Latanoprost	HUMAN PRESCRIPTION DRUG LABEL	1	50090-1920	SOLUTION/ DROPS	50 ug	OPHTHALMIC	ANDA	24 sections
Latanoprost	HUMAN PRESCRIPTION DRUG LABEL	1	50090-1920	SOLUTION/ DROPS	50 ug	OPHTHALMIC	ANDA	24 sections
Latanoprost	HUMAN PRESCRIPTION DRUG LABEL	1	54868-6254	SOLUTION/ DROPS	50 ug	OPHTHALMIC	ANDA	26 sections
LATANOPROST	HUMAN PRESCRIPTION DRUG LABEL	1	55545-1010	SOLUTION	50 ug	OPHTHALMIC	ANDA	24 sections
Latanoprost	HUMAN PRESCRIPTION DRUG LABEL	1	59762-0333	SOLUTION	50 ug	OPHTHALMIC	NDA AUTHORIZED GENERIC	25 sections
Latanoprost	HUMAN PRESCRIPTION DRUG LABEL	1	59762-0333	SOLUTION	50 ug	OPHTHALMIC	NDA AUTHORIZED GENERIC	25 sections
Latanoprost	HUMAN PRESCRIPTION DRUG LABEL	1	61314-547	SOLUTION	50 ug	OPHTHALMIC	ANDA	24 sections
Latanoprost	HUMAN PRESCRIPTION DRUG LABEL	1	61314-547	SOLUTION	50 ug	OPHTHALMIC	ANDA	24 sections
LATANOPROST	HUMAN PRESCRIPTION DRUG LABEL	1	61919-112	SOLUTION/ DROPS	50 ug	OPHTHALMIC	ANDA	12 sections
LATANOPROST	HUMAN PRESCRIPTION DRUG LABEL	1	64980-516	SOLUTION	50 ug	OPHTHALMIC	ANDA	24 sections
LATANOPROST	HUMAN PRESCRIPTION DRUG LABEL	1	64980-516	SOLUTION	50 ug	OPHTHALMIC	ANDA	24 sections
Latanoprost	Human Prescription Drug Label	1	65862-872	SOLUTION/ DROPS	50 ug	OPHTHALMIC	ANDA	24 sections
Latanoprost	Human Prescription Drug Label	1	65862-872	SOLUTION/ DROPS	50 ug	OPHTHALMIC	ANDA	24 sections
LATANOPROST	HUMAN PRESCRIPTION DRUG LABEL	1	68071-2376	SOLUTION/ DROPS	50 ug	OPHTHALMIC	ANDA	20 sections
Latanoprost	HUMAN PRESCRIPTION DRUG LABEL	1	68071-4612	SOLUTION/ DROPS	50 ug	OPHTHALMIC	ANDA	25 sections
Latanoprost	HUMAN PRESCRIPTION DRUG LABEL	1	68071-4650	SOLUTION/ DROPS	50 ug	OPHTHALMIC	ANDA	25 sections
LATANOPROST	HUMAN PRESCRIPTION DRUG LABEL	1	68071-4893	SOLUTION	50 ug	OPHTHALMIC	ANDA	24 sections
Xalatan	HUMAN PRESCRIPTION DRUG LABEL	1	68258-8976	SOLUTION	50 ug	OPHTHALMIC	NDA	24 sections
LATANOPROST	HUMAN PRESCRIPTION DRUG LABEL	1	70069-421	SOLUTION/ DROPS	50 ug	OPHTHALMIC	ANDA	20 sections