ketobemidone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 1526 | 469-79-4 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 50 | mg | O |
| 50 | mg | P |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 3.47 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BA (Bioavailability) | 34 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 0.48 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 9.20 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 2.30 hours | Lombardo F, Berellini G, Obach RS |
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Bocci G, Oprea TI, Benet LZ |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Jan. 1, 1947 | YEAR INTRODUCED |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | N02AB01 | NERVOUS SYSTEM ANALGESICS OPIOIDS Phenylpiperidine derivatives |
| ATC | N02AG02 | NERVOUS SYSTEM ANALGESICS OPIOIDS Opioids in combination with antispasmodics |
| MeSH PA | D000700 | Analgesics |
| MeSH PA | D000701 | Analgesics, Opioid |
| MeSH PA | D002491 | Central Nervous System Agents |
| MeSH PA | D002492 | Central Nervous System Depressants |
| MeSH PA | D018691 | Excitatory Amino Acid Antagonists |
| MeSH PA | D009294 | Narcotics |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
| MeSH PA | D018689 | Sensory System Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 9.35 | acidic |
| pKa2 | 8.84 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Mu-type opioid receptor | GPCR | EC50 | 9 | WOMBAT-PK | |||||
| Kappa-type opioid receptor | GPCR | Ki | 6.22 | WOMBAT-PK | |||||
| Glutamate receptor ionotropic, NMDA 3A | Ion channel | Ki | 4.59 | WOMBAT-PK | |||||
| Delta-type opioid receptor | GPCR | Ki | 6.85 | WOMBAT-PK | |||||
| Opioid receptor | GPCR | EC50 | 8.70 | CHEMBL | |||||
| Opioid receptor | GPCR | IC50 | 5.15 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D08100 | KEGG_DRUG |
| C0064311 | UMLSCUI |
| CHEBI:6125 | CHEBI |
| CHEMBL47072 | ChEMBL_ID |
| CHEMBL259124 | ChEMBL_ID |
| DB06738 | DRUGBANK_ID |
| C012394 | MESH_SUPPLEMENTAL_RECORD_UI |
| 10101 | PUBCHEM_CID |
| 1274 | INN_ID |
| PQS1L514CF | UNII |
| 015273 | NDDF |
| 96190002 | SNOMEDCT_US |
Pharmaceutical products:
None