fluostigmine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 1494 | 55-91-4 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A di-isopropyl-fluorophosphate which is an irreversible cholinesterase inhibitor used to investigate the NERVOUS SYSTEM.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| April 2, 1957 | FDA | MERCK |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | S01EB07 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIGLAUCOMA PREPARATIONS AND MIOTICS Parasympathomimetics |
| MeSH PA | D018678 | Cholinergic Agents |
| MeSH PA | D002800 | Cholinesterase Inhibitors |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D011480 | Protease Inhibitors |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Acetylcholinesterase | Enzyme | INHIBITOR | Ki | 5.22 | CHEMBL | CHEMBL | |||
| Prostaglandin G/H synthase 2 | Enzyme | Ki | 6.77 | PDSP | |||||
| Lysosomal protective protein | Enzyme | IC50 | 5 | CHEMBL | |||||
| Acetylcholinesterase | Enzyme | Kd | 4.15 | CHEMBL | |||||
| Acetylcholinesterase | Enzyme | IC50 | 6.32 | CHEMBL | |||||
| Liver carboxylesterase | Enzyme | IC50 | 7.30 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4017993 | VUID |
| N0000146338 | NUI |
| D00043 | KEGG_DRUG |
| 4017993 | VANDF |
| CHEBI:17941 | CHEBI |
| CHEMBL1025 | ChEMBL_ID |
| DB00677 | DRUGBANK_ID |
| 6027 | RXNORM |
| 4927 | MMSL |
| 001712 | NDDF |
| 373521002 | SNOMEDCT_US |
| 68424007 | SNOMEDCT_US |
| C0022181 | UMLSCUI |
| D007531 | MESH_DESCRIPTOR_UI |
| 5936 | PUBCHEM_CID |
| 12UHW9R67N | UNII |
Pharmaceutical products:
None