isoetarine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
bronchodilators, phenethylamine derivatives	1491	530-08-5

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

isoetharine mesilate
isoetharine
isoetharine mesylate
isoetarine
etyprenaline
isoctarine
isoetarin
isothurin
isoetharine hydrochloride
isoetharine mesylate salt
isoetharine HCl

Adrenergic beta-2 agonist used as bronchodilator for emphysema, bronchitis and asthma.

Molecular weight: 239.32
Formula: C13H21NO3
CLOGP: 0.99
LIPINSKI: 0
HAC: 4
HDO: 4
TPSA: 72.72
ALOGS: -1.88
ROTB: 5

Status: OFM

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
40	mg	O

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Oct. 23, 1979	FDA	ROXANE

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	R03AC07	RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES ADRENERGICS, INHALANTS Selective beta-2-adrenoreceptor agonists
ATC	R03CC06	RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES ADRENERGICS FOR SYSTEMIC USE Selective beta-2-adrenoreceptor agonists
MeSH PA	D018663	Adrenergic Agents
MeSH PA	D000322	Adrenergic Agonists
MeSH PA	D058666	Adrenergic beta-2 Receptor Agonists
MeSH PA	D000318	Adrenergic beta-Agonists
MeSH PA	D018927	Anti-Asthmatic Agents
MeSH PA	D001993	Bronchodilator Agents
MeSH PA	D018377	Neurotransmitter Agents
MeSH PA	D018373	Peripheral Nervous System Agents
MeSH PA	D019141	Respiratory System Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.76	acidic
pKa2	13.15	acidic
pKa3	13.89	acidic
pKa4	9.14	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Beta-2 adrenergic receptor	GPCR	P07550	ADRB2_HUMAN	AGONIST	Kd	6		CHEMBL	CHEMBL

External reference:

ID	Source
4019792	VUID
N0000147881	NUI
D02093	KEGG_DRUG
79490-84-9	SECONDARY_CAS_RN
7279-75-6	SECONDARY_CAS_RN
4018239	VANDF
4018240	VANDF
4019792	VANDF
C0022176	UMLSCUI
CHEBI:6005	CHEBI
CHEMBL1201213	ChEMBL_ID
CHEMBL1201153	ChEMBL_ID
7205	IUPHAR_LIGAND_ID
2576-92-3	SECONDARY_CAS_RN
3762	PUBCHEM_CID
DB00221	DRUGBANK_ID
102397	RXNORM
2951	MMSL
4924	MMSL
4925	MMSL
7493	MMSL
d00751	MMSL
001783	NDDF
001784	NDDF
001785	NDDF
386181008	SNOMEDCT_US
387369005	SNOMEDCT_US
66004009	SNOMEDCT_US
81860007	SNOMEDCT_US
D007528	MESH_DESCRIPTOR_UI
CHEMBL1200920	ChEMBL_ID
1384	INN_ID
YV0SN3276Q	UNII

Pharmaceutical products:

None