iprazochrome 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
1476 7248-21-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • iprazochrome
  • divascan
  • isopropylnoradenochrome monosemicarbazone
  • isopropylnoradrenochrome monosemicarbazone
used in prophylaxis of migraine
  • Molecular weight: 264.29
  • Formula: C12H16N4O3
  • CLOGP: 0.45
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 3
  • TPSA: 108.02
  • ALOGS: -2.27
  • ROTB: 2

Drug dosage:

DoseUnitRoute
24 mg O

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,ACVRL1,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GSK3B,ITK,JAK1,JAK2,KIT,MAP2K6,MAP3K14,MAP3K21,MAP3K7,MAP4K1,MAPK10,MAPK7,MAPK9,MARK4,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIM2,PLK1,PLK2,PLK3,PLK4,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1 58
kinase-selectivity-class ACVR2B,AXL,BRAF,CAMK2D,CDK16,CDK4,CDK9,CLK2,CLK4,DDR1,DYRK1A,DYRK1B,EIF2AK3,GRK2,JAK2,MAP2K6,MAP3K14,MAPK7,PDK1,SIK2,STK33,TEK,TGFBR1,TTK 24
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N02CX03 NERVOUS SYSTEM
ANALGESICS
ANTIMIGRAINE PREPARATIONS
Other antimigraine preparations
MeSH PA D012702 Serotonin Antagonists
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018490 Serotonin Agents

Related Drugs by ATC class:

N02CX Other antimigraine preparations 4 drugs
clonidinedimetotiazineoxetoronepizotifen

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.86 acidic
pKa2 2.34 Basic
pKa3 1.41 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D07297 KEGG_DRUG
C0123902 UMLSCUI
CHEBI:135088 CHEBI
CHEMBL4297107 ChEMBL_ID
DB13541 DRUGBANK_ID
C009742 MESH_SUPPLEMENTAL_RECORD_UI
65594 PUBCHEM_CID
4427 INN_ID
903A9K181P UNII
51486 RXNORM
006714 NDDF

Pharmaceutical products:

None