ibuprofen 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
anti-inflammatory agents, ibuprofen derivatives 1407 15687-27-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • ibuprofen lysine
  • ibuprofen lysinate
  • ibuprofen lysine salt
  • soluphene
  • solufenum
  • neoprofen
  • ibuprofen
  • ibuprofen sodium
A nonsteroidal anti-inflammatory agent with analgesic properties used in the treatment of RHEUMATISM and ARTHRITIS. Concerns that anti-inflammatory drugs such as ibuprofen may worsen COVID-19 circulated widely in the early months of the pandemic. FDA has stated that it is not aware of scientific evidence connecting the use of NSAIAs, such as ibuprofen, with worsening COVID-19 symptoms and will communicate publicly when more information is available.
  • Molecular weight: 206.29
  • Formula: C13H18O2
  • CLOGP: 3.68
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 37.30
  • ALOGS: -3.48
  • ROTB: 4
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
30 mg P
1.20 g O
1.20 g P
1.20 g R

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.04 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 193.90 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 85 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.15 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.82 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.01 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 1.60 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Sept. 19, 1974 FDA
Jan. 19, 2018 PMDA Senju Pharmaceutical Co., Ltd.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Intentional overdose 1007.13 9.88 1690 380867 72462 63034003
Muscle injury 615.54 9.88 1273 381284 64072 63042393
Irritable bowel syndrome 588.72 9.88 1438 381119 80974 63025491
Folliculitis 583.25 9.88 1301 381256 69016 63037449
Cholecystitis chronic 509.38 9.88 454 382103 9907 63096558
Injury 498.75 9.88 1255 381302 71992 63034473
Angioedema 483.24 9.88 961 381596 47004 63059461
Lower respiratory tract infection 463.66 9.88 1799 380758 130508 62975957
Blister 458.90 9.88 1770 380787 128044 62978421
Sleep disorder due to general medical condition, insomnia type 430.55 9.88 964 381593 51253 63055212
Death 422.71 9.88 1027 381530 373354 62733111
Impaired healing 417.72 9.88 1464 381093 101078 63005387
Off label use 392.00 9.88 2422 380135 672040 62434425
Suicide attempt 364.80 9.88 995 381562 59923 63046542
Pneumonia 343.89 9.88 1500 381057 455267 62651198
Gastrointestinal disorder 337.80 9.88 1626 380931 129613 62976852
Abdominal pain upper 318.08 9.88 2232 380325 204212 62902253
Urticaria 305.48 9.88 1875 380682 163927 62942538
Ill-defined disorder 293.87 9.88 1121 381436 80634 63025831
Pruritus 287.55 9.88 3385 379172 358068 62748397
Sinusitis 275.72 9.88 2319 380238 224334 62882131
Emotional distress 269.49 9.88 602 381955 31947 63074518
Duodenal ulcer perforation 268.87 9.88 1140 381417 86069 63020396
Stomatitis 266.41 9.88 1586 380971 137139 62969326
Muscle spasticity 233.21 9.88 448 382109 21346 63085119
Drug hypersensitivity 226.64 9.88 2863 379694 307824 62798641
Helicobacter infection 222.55 9.88 1127 381430 91658 63014807
Ear pain 214.24 9.88 588 381969 35530 63070935
Tubulointerstitial nephritis 210.36 9.88 407 382150 19496 63086969
Uterine perforation 208.46 9.88 233 382324 6730 63099735
Peripheral swelling 205.22 9.88 2477 380080 263465 62843000
Aspirin-exacerbated respiratory disease 203.27 9.88 102 382455 793 63105672
Oligohydramnios 202.66 9.88 220 382337 6146 63100319
Febrile neutropenia 198.61 9.88 253 382304 118196 62988269
Overdose 186.36 9.88 1260 381297 113818 62992647
Deafness transitory 185.90 9.88 127 382430 1843 63104622
Renal tubular acidosis 181.16 9.88 118 382439 1574 63104891
Lip oedema 179.24 9.88 165 382392 3759 63102706
Cardiac failure 172.89 9.88 169 382388 88973 63017492
Fall 167.50 9.88 1534 381023 390800 62715665
Interstitial lung disease 163.91 9.88 84 382473 61824 63044641
Night sweats 162.10 9.88 653 381904 48161 63058304
Infection 160.22 9.88 2096 380461 227077 62879388
Cardiac failure congestive 156.43 9.88 196 382361 92237 63014228
Nasopharyngitis 154.48 9.88 2268 380289 251989 62854476
Gallbladder disorder 154.28 9.88 347 382210 18495 63087970
Neutropenia 146.84 9.88 550 382007 174455 62932010
Malignant neoplasm progression 144.41 9.88 169 382388 81952 63024513
Biliary dyskinesia 138.96 9.88 122 382435 2607 63103858
Body temperature increased 138.56 9.88 516 382041 36676 63069789
Haematemesis 138.52 9.88 451 382106 29961 63076504
Joint swelling 138.38 9.88 2756 379801 324910 62781555
Intentional self-injury 133.70 9.88 399 382158 25288 63081177
Disease progression 130.24 9.88 347 382210 122411 62984054
Deep vein thrombosis 129.38 9.88 907 381650 82893 63023572
Hypersensitivity 127.66 9.88 2474 380083 290211 62816254
Respiratory disorder 127.52 9.88 520 382037 38562 63067903
Gastrointestinal pain 124.90 9.88 217 382340 9559 63096906
Drug ineffective 123.54 9.88 5099 377458 1039666 62066799
Therapeutic product effect decreased 122.72 9.88 1737 380820 191450 62915015
Completed suicide 121.13 9.88 1377 381180 144296 62962169
Toxicity to various agents 118.55 9.88 2121 380436 245129 62861336
Sepsis 113.52 9.88 505 382052 152618 62953847
Confusional state 113.40 9.88 2028 380529 234352 62872113
Stevens-Johnson syndrome 112.73 9.88 369 382188 24581 63081884
Metabolic acidosis 111.94 9.88 553 382004 44516 63061949
Platelet count decreased 111.62 9.88 344 382213 115778 62990687
Gastric ulcer 109.06 9.88 356 382201 23681 63082784
Anaemia 108.15 9.88 1188 381369 292242 62814223
Thrombocytopenia 104.10 9.88 512 382045 150645 62955820
Atrial fibrillation 101.46 9.88 361 382196 116275 62990190
Hospitalisation 97.61 9.88 231 382326 84850 63021615
Toxic epidermal necrolysis 94.79 9.88 352 382205 24982 63081483
Weight increased 93.67 9.88 2143 380414 258649 62847816
Cholelithiasis 92.58 9.88 515 382042 43410 63063055
Drug resistance 92.15 9.88 14 382543 22919 63083546
Sleep disorder 91.88 9.88 821 381736 80745 63025720
Gastric ulcer perforation 87.64 9.88 67 382490 1169 63105296
Macular degeneration 87.02 9.88 20 382537 24356 63082109
Eyelid oedema 86.92 9.88 194 382363 10285 63096180
Hypervolaemia 82.27 9.88 34 382523 28379 63078086
Pericarditis 82.26 9.88 1180 381377 130399 62976066
Meningitis aseptic 82.10 9.88 122 382435 4701 63101764
Peritonsillar abscess 81.64 9.88 48 382509 527 63105938
Fixed eruption 80.13 9.88 62 382495 1102 63105363
Fluid retention 79.41 9.88 149 382408 59537 63046928
Pain 78.50 9.88 5320 377237 735308 62371157
Diarrhoea 78.20 9.88 3520 379037 711846 62394619
Orthostatic hypotension 77.99 9.88 62 382495 36098 63070367
Discomfort 76.70 9.88 1426 381131 165948 62940517
Acute kidney injury 76.60 9.88 2104 380453 261311 62845154
Upper gastrointestinal haemorrhage 76.53 9.88 269 382288 18583 63087882
Renal impairment 76.47 9.88 274 382283 88081 63018384
Duodenal ulcer 76.39 9.88 154 382403 7602 63098863
Urinary tract infection 76.13 9.88 1129 381428 263555 62842910
Contusion 76.08 9.88 1299 381258 148745 62957720
Kounis syndrome 75.65 9.88 71 382486 1659 63104806
Myocardial infarction 74.28 9.88 329 382228 99564 63006901
Face oedema 74.09 9.88 279 382278 19933 63086532
Anhedonia 73.54 9.88 187 382370 10787 63095678
Anti-cyclic citrullinated peptide antibody positive 73.36 9.88 1044 381513 115168 62991297
Swelling 73.27 9.88 2175 380382 273203 62833262
Plasma cell myeloma 73.22 9.88 65 382492 35840 63070625
Haemoglobin decreased 72.74 9.88 545 382012 144940 62961525
Femur fracture 72.25 9.88 87 382470 41669 63064796
Chronic obstructive pulmonary disease 72.06 9.88 170 382387 62516 63043949
Vomiting 71.82 9.88 4088 378469 555529 62550936
Pharyngitis 71.33 9.88 275 382282 19868 63086597
Gallbladder injury 71.22 9.88 63 382494 1360 63105105
Cytomegalovirus infection 69.41 9.88 20 382537 20932 63085533
Wound closure 68.72 9.88 26 382531 90 63106375
Pancytopenia 68.06 9.88 326 382231 96607 63009858
Neuropathy peripheral 67.75 9.88 404 382153 113263 62993202
Malaise 67.06 9.88 1951 380606 414003 62692462
Analgesic drug level increased 66.97 9.88 77 382480 2295 63104170
Enthesopathy 66.49 9.88 155 382402 8459 63098006
White blood cell count decreased 65.84 9.88 529 382028 138575 62967890
Red blood cell sedimentation rate abnormal 65.32 9.88 19 382538 19763 63086702
Treatment failure 65.11 9.88 827 381730 198216 62908249
Myelosuppression 64.48 9.88 31 382526 23672 63082793
Cardiac disorder 63.17 9.88 132 382425 50684 63055781
Herpes zoster 62.88 9.88 269 382288 82193 63024272
Clostridium difficile infection 62.43 9.88 53 382504 29869 63076596
Bezoar 61.74 9.88 60 382497 1466 63104999
Neutrophil count decreased 61.66 9.88 157 382400 56249 63050216
Septic shock 61.47 9.88 201 382356 66428 63040037
Pleural effusion 61.14 9.88 321 382236 92889 63013576
Hypoaldosteronism 59.89 9.88 27 382530 160 63106305
Hypomagnesaemia 59.84 9.88 51 382506 28686 63077779
Pulmonary embolism 59.79 9.88 1012 381545 115672 62990793
Wrong technique in product usage process 59.65 9.88 185 382372 62155 63044310
Osteoporosis 59.34 9.88 164 382393 57174 63049291
Vanishing bile duct syndrome 59.33 9.88 43 382514 689 63105776
Melaena 58.73 9.88 348 382209 30017 63076448
Dehydration 58.67 9.88 715 381842 172639 62933826
Ductus arteriosus premature closure 58.36 9.88 32 382525 304 63106161
Gastritis 58.28 9.88 405 382152 36898 63069567
Blood pressure increased 57.70 9.88 661 381896 161401 62945064
Pulmonary arterial hypertension 56.31 9.88 33 382524 22544 63083921
Anxiety 55.35 9.88 1709 380848 215832 62890633
Rash 54.95 9.88 4004 378553 556867 62549598
Product prescribing error 54.57 9.88 307 382250 25982 63080483
Hyponatraemia 54.12 9.88 423 382134 111477 62994988
Bone marrow failure 53.96 9.88 58 382499 29232 63077233
Cough 53.92 9.88 1347 381210 291396 62815069
Lip swelling 53.79 9.88 346 382211 30717 63075748
Osteotomy 53.69 9.88 27 382530 211 63106254
Foreign body in throat 53.41 9.88 30 382527 300 63106165
Transplant rejection 52.74 9.88 3 382554 10777 63095688
Bronchitis 51.63 9.88 492 382065 124443 62982022
Leukopenia 50.79 9.88 266 382291 77024 63029441
Biliary colic 49.79 9.88 83 382474 3534 63102931
Dyspnoea exertional 49.56 9.88 191 382366 60111 63046354
Pulmonary hypertension 49.09 9.88 93 382464 37030 63069435
Acute myeloid leukaemia 48.87 9.88 21 382536 17126 63089339
Bradycardia 48.69 9.88 251 382306 72976 63033489
Pneumocystis jirovecii pneumonia 47.75 9.88 21 382536 16893 63089572
Ductus arteriosus stenosis foetal 47.73 9.88 23 382534 162 63106303
Arthralgia 47.24 9.88 4015 378542 565695 62540770
Self-medication 47.18 9.88 70 382487 2693 63103772
Gastrointestinal haemorrhage 47.18 9.88 719 381838 80457 63026008
Gallbladder cholesterolosis 47.10 9.88 39 382518 767 63105698
Respiratory failure 46.97 9.88 390 382167 101468 63004997
Hypocalcaemia 46.91 9.88 74 382483 31639 63074826
Oesophageal obstruction 46.74 9.88 34 382523 548 63105917
Oxygen saturation decreased 46.11 9.88 328 382229 88257 63018208
Ankylosing spondylitis 45.61 9.88 153 382404 10321 63096144
Shoulder arthroplasty 44.95 9.88 84 382473 3918 63102547
Dementia 44.75 9.88 29 382528 18765 63087700
Productive cough 44.70 9.88 212 382345 62996 63043469
Neonatal cardiac failure 44.58 9.88 12 382545 6 63106459
Multiple organ dysfunction syndrome 44.58 9.88 183 382374 56569 63049896
Tenosynovitis 44.55 9.88 183 382374 13612 63092853
Insomnia 44.11 9.88 1649 380908 213603 62892862
Myelodysplastic syndrome 43.94 9.88 23 382534 16731 63089734
Rheumatoid arthritis 43.60 9.88 1908 380649 251911 62854554
Pulmonary infarction 43.23 9.88 67 382490 2680 63103785
Transfusion 42.79 9.88 19 382538 15198 63091267
Systemic lupus erythematosus rash 42.76 9.88 60 382497 2192 63104273
Pneumonia aspiration 42.69 9.88 90 382467 34450 63072015
Product use issue 42.68 9.88 1007 381550 219513 62886952
Acute lung injury 42.68 9.88 50 382507 1521 63104944
Bronchiectasis 42.57 9.88 22 382535 16120 63090345
Constipation 42.49 9.88 1031 381526 223912 62882553
Functional gastrointestinal disorder 42.46 9.88 85 382472 4174 63102291
Device related infection 42.34 9.88 47 382510 23345 63083120
Frequent bowel movements 41.96 9.88 46 382511 22976 63083489
Medication error 41.52 9.88 490 382067 51794 63054671
Tongue disorder 41.26 9.88 149 382408 10431 63096034
Jejunal ulcer 41.17 9.88 18 382539 98 63106367
Premature delivery 40.80 9.88 75 382482 30206 63076259
Neurotoxicity 40.75 9.88 26 382531 16964 63089501
Duodenal ulcer haemorrhage 39.99 9.88 61 382496 2406 63104059
Medication overuse headache 39.99 9.88 36 382521 796 63105669
Hypotension 39.85 9.88 1295 381262 271309 62835156
Hip fracture 39.71 9.88 73 382484 29401 63077064
General physical health deterioration 39.61 9.88 1536 381021 199866 62906599
Serotonin syndrome 39.57 9.88 70 382487 28612 63077853
Sedation 39.42 9.88 112 382445 38697 63067768
Oedema peripheral 39.33 9.88 856 381701 188655 62917810
Sedation complication 39.28 9.88 17 382540 13805 63092660
Abdominal pain lower 39.06 9.88 277 382280 25401 63081064
Creatinine renal clearance decreased 39.05 9.88 25 382532 16283 63090182
Right ventricular failure 38.95 9.88 28 382529 17160 63089305
Full blood count abnormal 38.90 9.88 83 382474 31634 63074831
Ascites 38.87 9.88 121 382436 40607 63065858
Lemierre syndrome 38.82 9.88 17 382540 93 63106372
Diabetes mellitus 38.41 9.88 189 382368 55621 63050844
Tendonitis 38.06 9.88 225 382332 19390 63087075
Heavy menstrual bleeding 37.85 9.88 209 382348 17564 63088901
Embedded device 37.75 9.88 72 382485 3411 63103054
Foetal acidosis 37.74 9.88 11 382546 11 63106454
Mucosal inflammation 37.69 9.88 150 382407 46778 63059687
Loss of personal independence in daily activities 37.33 9.88 390 382167 96900 63009565
Gastric perforation 36.85 9.88 48 382509 1631 63104834
Cytopenia 36.76 9.88 12 382545 11589 63094876
Toxic shock syndrome streptococcal 36.48 9.88 17 382540 110 63106355
Musculoskeletal disorder 36.39 9.88 231 382326 20413 63086052
Cerebrovascular accident 36.35 9.88 446 382111 107578 62998887
Intestinal obstruction 36.14 9.88 83 382474 30816 63075649
Red blood cell sedimentation rate 36.01 9.88 86 382471 4768 63101697
Medical device discomfort 35.84 9.88 51 382506 1888 63104577
Foot operation 35.45 9.88 110 382447 7121 63099344
Cholesterosis 35.23 9.88 26 382531 429 63106036
Product dose omission issue 35.22 9.88 1109 381448 233204 62873261
Cataract 34.93 9.88 201 382356 56852 63049613
Musculoskeletal stiffness 34.67 9.88 1401 381156 183217 62923248
Posterior reversible encephalopathy syndrome 34.65 9.88 32 382525 17313 63089152
Cholecystitis acute 34.51 9.88 119 382438 8141 63098324
Gastritis erosive 34.50 9.88 97 382460 5942 63100523
Pain in jaw 34.32 9.88 140 382417 43356 63063109
Acute generalised exanthematous pustulosis 34.10 9.88 145 382412 10954 63095511
Tongue oedema 33.75 9.88 81 382476 4505 63101960
Psoriatic arthropathy 33.70 9.88 755 381802 90765 63015700
Blood glucose increased 33.68 9.88 332 382225 83424 63023041
Pharyngeal abscess 33.43 9.88 21 382536 262 63106203
Acute hepatic failure 32.88 9.88 206 382351 18121 63088344
Bone erosion 32.73 9.88 35 382522 17682 63088783
Adjustment disorder with depressed mood 32.67 9.88 135 382422 10069 63096396
Unevaluable event 32.56 9.88 179 382378 51207 63055258
Balance disorder 32.56 9.88 338 382219 84084 63022381
Glomerulonephritis membranous 32.53 9.88 28 382529 582 63105883
Device expulsion 32.45 9.88 105 382452 34817 63071648
Open globe injury 32.29 9.88 12 382545 39 63106426
Ear infection 32.07 9.88 362 382195 37851 63068614
Obstructive airways disorder 31.86 9.88 47 382510 20652 63085813
Pelvic pain 31.53 9.88 163 382394 13356 63093109
Palatal oedema 31.50 9.88 27 382530 558 63105907
Periorbital oedema 31.21 9.88 90 382467 5594 63100871
Bronchopulmonary aspergillosis 30.99 9.88 7 382550 8628 63097837
Inappropriate schedule of product administration 30.69 9.88 441 382116 103524 63002941
C-reactive protein abnormal 30.64 9.88 418 382139 45678 63060787
Hepatitis cholestatic 30.42 9.88 101 382456 6777 63099688
Perichondritis 30.39 9.88 12 382545 48 63106417
Hunger 30.34 9.88 86 382471 5293 63101172
Cytokine release syndrome 30.30 9.88 25 382532 14289 63092176
Rheumatoid nodule 30.26 9.88 192 382365 16963 63089502
Metastases to bone 30.19 9.88 50 382507 20969 63085496
Hypoglycaemia 30.00 9.88 225 382332 59840 63046625
Injection site pain 29.98 9.88 576 381981 129224 62977241
Gallbladder hypofunction 29.75 9.88 26 382531 552 63105913
Foreign body in gastrointestinal tract 29.54 9.88 11 382546 36 63106429
Multiple sclerosis 29.34 9.88 249 382308 24123 63082342
Eosinophilic oesophagitis 29.32 9.88 21 382536 330 63106135
Pelvic venous thrombosis 29.31 9.88 44 382513 1711 63104754
Tumour lysis syndrome 29.02 9.88 9 382548 8981 63097484
Renal papillary necrosis 28.94 9.88 19 382538 257 63106208
Metastases to liver 28.88 9.88 62 382495 23577 63082888
Torsade de pointes 28.65 9.88 23 382534 13328 63093137
Gastrointestinal toxicity 28.49 9.88 107 382450 7634 63098831
Thrombotic microangiopathy 28.44 9.88 14 382543 10547 63095918
Hepatic function abnormal 28.40 9.88 121 382436 37021 63069444
Nasal disorder 28.36 9.88 57 382500 2807 63103658
Necrotising fasciitis 28.32 9.88 59 382498 2982 63103483
Cardiac failure acute 28.21 9.88 11 382546 9512 63096953
Hypertension 28.20 9.88 1385 381172 277918 62828547
Breast cancer stage I 28.15 9.88 4 382553 6885 63099580
Laryngeal oedema 28.04 9.88 87 382470 5631 63100834
Full blood count decreased 28.01 9.88 73 382484 25951 63080514
Duodenitis haemorrhagic 27.96 9.88 8 382549 7 63106458
Lung neoplasm malignant 27.92 9.88 47 382510 19586 63086879
Suspected suicide 27.77 9.88 95 382462 6473 63099992
Exposure during pregnancy 27.72 9.88 719 381838 154828 62951637
Therapeutic product effect incomplete 27.65 9.88 559 381998 124497 62981968
Pneumonia viral 27.30 9.88 7 382550 7915 63098550
Drug level decreased 27.28 9.88 7 382550 7912 63098553
Dyskinesia 27.18 9.88 100 382457 31902 63074563
Brain death 27.02 9.88 62 382495 3348 63103117
Aorto-oesophageal fistula 26.96 9.88 9 382548 19 63106446
Thyroid disorder 26.86 9.88 31 382526 15131 63091334
Pericardial effusion 26.81 9.88 92 382465 29966 63076499
Lip dry 26.59 9.88 172 382385 15298 63091167
Electrocardiogram QT prolonged 26.51 9.88 230 382327 59300 63047165
Hyperglycaemia 26.44 9.88 146 382411 41721 63064744
Blood pressure systolic increased 26.39 9.88 172 382385 47225 63059240
Brain empyema 26.35 9.88 7 382550 3 63106462
Heart rate decreased 26.05 9.88 164 382393 45396 63061069
Extrapyramidal disorder 25.96 9.88 25 382532 13259 63093206
Poisoning 25.84 9.88 156 382401 13544 63092921
Immunodeficiency 25.69 9.88 52 382505 20202 63086263
Pathogen resistance 25.49 9.88 4 382553 6394 63100071
Glaucoma 25.31 9.88 47 382510 18858 63087607
Corneal leukoma 25.30 9.88 8 382549 13 63106452
Red blood cell count decreased 24.98 9.88 143 382414 40502 63065963
Protein-losing gastroenteropathy 24.85 9.88 16 382541 209 63106256
Epilepsy 24.71 9.88 82 382475 26983 63079482
Tonsillar erythema 24.71 9.88 6 382551 0 63106465
Genital odour 24.71 9.88 6 382551 0 63106465
Aspergillus infection 24.56 9.88 9 382548 8084 63098381
Oral candidiasis 24.50 9.88 64 382493 22734 63083731
Blood magnesium decreased 24.46 9.88 26 382531 13172 63093293
Dislocation of vertebra 24.39 9.88 110 382447 8525 63097940
Staphylococcal infection 24.37 9.88 147 382410 41109 63065356
Condition aggravated 24.24 9.88 2090 380467 400127 62706338
Drug interaction 24.15 9.88 1131 381426 228000 62878465
Flushing 24.14 9.88 313 382244 74774 63031691
Temperature regulation disorder 24.06 9.88 4 382553 6128 63100337
Diabetic ketoacidosis 24.05 9.88 55 382502 20450 63086015
Infected dermal cyst 24.02 9.88 21 382536 446 63106019
Unintentional medical device removal 23.97 9.88 4 382553 6111 63100354
Second primary malignancy 23.87 9.88 9 382548 7944 63098521
Underdose 23.84 9.88 85 382472 27371 63079094
Hepatic enzyme increased 23.72 9.88 1467 381090 200861 62905604
Autoimmune disorder 23.67 9.88 181 382376 16996 63089469
Parkinsonism 23.66 9.88 17 382540 10422 63096043
Progressive multifocal leukoencephalopathy 23.55 9.88 26 382531 12945 63093520
Cardiotoxicity 23.01 9.88 11 382546 8427 63098038
Blood pressure fluctuation 22.89 9.88 174 382383 46143 63060322
Respiratory tract infection 22.87 9.88 151 382406 41332 63065133
Therapy interrupted 22.86 9.88 109 382448 32346 63074119
Coeliac disease 22.85 9.88 26 382531 12771 63093694
Medical device pain 22.75 9.88 37 382520 1543 63104922
Chondritis 22.67 9.88 7 382550 10 63106455
Cystitis 22.52 9.88 217 382340 54774 63051691
Distichiasis 22.50 9.88 8 382549 22 63106443
Serum sickness-like reaction 22.43 9.88 21 382536 489 63105976
Cellulitis 22.35 9.88 353 382204 81605 63024860
Ventricular tachycardia 22.31 9.88 55 382502 19924 63086541
Pulmonary oedema 22.27 9.88 217 382340 54656 63051809
Anti-cyclic citrullinated peptide antibody 22.10 9.88 90 382467 6668 63099797
Blood pressure decreased 22.04 9.88 268 382289 64754 63041711
Breast cancer 21.96 9.88 186 382371 48197 63058268
Osteonecrosis of jaw 21.90 9.88 123 382434 35000 63071465
Cushingoid 21.74 9.88 12 382545 8473 63097992
Cholecystitis 21.74 9.88 163 382394 15214 63091251
Hyperkalaemia 21.73 9.88 215 382342 53988 63052477
Laryngeal discomfort 21.70 9.88 17 382540 308 63106157
Acute pulmonary oedema 21.69 9.88 11 382546 8147 63098318
Deformity 21.68 9.88 23 382534 11661 63094804
Cerebral venous sinus thrombosis 21.66 9.88 41 382516 1931 63104534
Embolism arterial 21.62 9.88 28 382529 946 63105519
Blood calcium decreased 21.59 9.88 84 382473 26367 63080098
Facet joint syndrome 21.51 9.88 136 382421 12002 63094463
Psychological trauma 21.48 9.88 30 382527 1091 63105374
Influenza 21.42 9.88 495 382062 108227 62998238
Neoplasm progression 21.41 9.88 130 382427 36298 63070167
Diffuse large B-cell lymphoma 21.17 9.88 7 382550 6705 63099760
Deep vein thrombosis postoperative 21.16 9.88 129 382428 11240 63095225
Multiple sclerosis relapse 21.13 9.88 410 382147 48068 63058397
Type IV hypersensitivity reaction 21.13 9.88 51 382506 2847 63103618
Breath sounds abnormal 21.04 9.88 21 382536 10952 63095513
Abdominal pain 21.00 9.88 2047 380510 291409 62815056
Kidney enlargement 20.97 9.88 23 382534 650 63105815
Blood creatine phosphokinase increased 20.97 9.88 103 382454 30327 63076138
Muscle rigidity 20.93 9.88 23 382534 11477 63094988
Infertility female 20.80 9.88 21 382536 538 63105927
Psychotic disorder 20.76 9.88 82 382475 25630 63080835
Myoclonus 20.76 9.88 40 382517 15828 63090637
Internal injury 20.76 9.88 17 382540 329 63106136
Stress cardiomyopathy 20.63 9.88 16 382541 9434 63097031
Osteonecrosis 20.60 9.88 77 382480 24453 63082012
Viral parotitis 20.59 9.88 5 382552 0 63106465
Grip strength decreased 20.48 9.88 215 382342 22072 63084393
Poor venous access 20.47 9.88 36 382521 14749 63091716
Hepatic necrosis 20.43 9.88 78 382479 5609 63100856
Pneumonia streptococcal 20.33 9.88 38 382519 1773 63104692
Schizophrenia 20.31 9.88 18 382539 9934 63096531
Synovitis 20.22 9.88 1346 381211 185572 62920893
Mania 20.11 9.88 27 382530 12340 63094125
Hypoxia 20.06 9.88 247 382310 59545 63046920
Enzyme induction 20.01 9.88 9 382548 53 63106412
Dysmenorrhoea 20.00 9.88 61 382496 3912 63102553
Bacteraemia 19.97 9.88 47 382510 17301 63089164
Urosepsis 19.90 9.88 52 382505 18472 63087993
Diabetes mellitus inadequate control 19.90 9.88 38 382519 15088 63091377
Hepatic cirrhosis 19.90 9.88 79 382478 24655 63081810
Renal failure 19.86 9.88 548 382009 117104 62989361
Breast cancer female 19.71 9.88 32 382525 13527 63092938
Genital tract inflammation 19.70 9.88 8 382549 35 63106430
Beta haemolytic streptococcal infection 19.70 9.88 40 382517 1985 63104480
Myopathy 19.70 9.88 23 382534 11168 63095297
Ceruloplasmin decreased 19.67 9.88 6 382551 8 63106457
Spinal compression fracture 19.58 9.88 35 382522 14248 63092217
Necrosis ischaemic 19.53 9.88 25 382532 835 63105630
Blood parathyroid hormone decreased 19.44 9.88 113 382444 9678 63096787
Rales 19.38 9.88 29 382528 12668 63093797
Hypertensive emergency 19.29 9.88 38 382519 1844 63104621
Device malfunction 19.28 9.88 50 382507 17807 63088658
Posthaemorrhagic hydrocephalus 19.25 9.88 7 382550 21 63106444
Acute myocardial infarction 19.22 9.88 114 382443 32010 63074455
Gastric ulcer haemorrhage 19.03 9.88 69 382488 4839 63101626
Genital haemorrhage 18.94 9.88 91 382466 7241 63099224
Fear 18.94 9.88 161 382396 15605 63090860
Product use in unapproved indication 18.85 9.88 884 381673 178196 62928269
Oligoarthritis 18.64 9.88 20 382537 551 63105914
Blood potassium increased 18.47 9.88 53 382504 18256 63088209
Electrocardiogram U-wave abnormality 18.34 9.88 7 382550 25 63106440
Disease recurrence 18.11 9.88 97 382460 27933 63078532
Blood glucose decreased 18.10 9.88 65 382492 20887 63085578
Injection site extravasation 18.03 9.88 16 382541 8825 63097640
Headache 17.98 9.88 4190 378367 629051 62477414
Haematotoxicity 17.91 9.88 18 382539 9358 63097107
Febrile bone marrow aplasia 17.86 9.88 11 382546 7314 63099151
Tardive dyskinesia 17.81 9.88 15 382542 8487 63097978
Intestinal diaphragm disease 17.80 9.88 10 382547 100 63106365
Skin cancer 17.79 9.88 26 382531 11469 63094996
Scar 17.77 9.88 143 382414 13639 63092826
Nodule 17.66 9.88 66 382491 20960 63085505
Maternal exposure timing unspecified 17.62 9.88 87 382470 7000 63099465
Joint injury 17.59 9.88 263 382294 29309 63077156
Food refusal 17.58 9.88 16 382541 359 63106106
Acute haemorrhagic oedema of infancy 17.57 9.88 6 382551 14 63106451
Depression 17.51 9.88 1393 381164 195099 62911366
Sleep disorder due to a general medical condition 17.50 9.88 29 382528 12159 63094306
Staphylococcal sepsis 17.45 9.88 14 382543 8114 63098351
Aplasia pure red cell 17.44 9.88 3 382554 4484 63101981
Panniculitis 17.42 9.88 123 382434 11262 63095203
Abnormal loss of weight 17.35 9.88 75 382482 5707 63100758
Jaundice 17.34 9.88 260 382297 28991 63077474
Sacroiliitis 17.33 9.88 51 382506 3206 63103259
Cholecystectomy 17.31 9.88 117 382440 10560 63095905
Liver injury 17.14 9.88 482 382075 60038 63046427
Arthritis 17.07 9.88 550 382007 115371 62991094
Peripheral venous disease 17.01 9.88 155 382402 15322 63091143
Injection site hyperaesthesia 17.01 9.88 8 382549 53 63106412
Cerebral infarction 16.97 9.88 80 382477 23813 63082652
Drug withdrawal headache 16.89 9.88 8 382549 54 63106411
Uterine leiomyoma 16.88 9.88 104 382453 9094 63097371
Dermo-hypodermitis 16.88 9.88 14 382543 276 63106189
Cerebral haemorrhage 16.86 9.88 112 382445 30617 63075848
Back pain 16.82 9.88 1828 380729 262317 62844148
Metastases to lung 16.80 9.88 32 382525 12718 63093747
Effusion 16.79 9.88 34 382523 1684 63104781
Pulmonary fibrosis 16.76 9.88 156 382401 39653 63066812
Haematochezia 16.75 9.88 432 382125 53112 63053353
Renal disorder 16.71 9.88 123 382434 32851 63073614
Scleroderma 16.70 9.88 6 382551 5456 63101009
Hemiplegia 16.58 9.88 19 382538 9304 63097161
Granuloma skin 16.51 9.88 97 382460 8340 63098125
Shoulder injury related to vaccine administration 16.47 9.88 4 382553 0 63106465
Bunion operation 16.44 9.88 29 382528 1293 63105172
Deafness 16.40 9.88 173 382384 17784 63088681
Malnutrition 16.39 9.88 43 382514 15255 63091210
Cognitive disorder 16.38 9.88 237 382320 55578 63050887
Coma scale abnormal 16.36 9.88 68 382489 5085 63101380
Clostridium difficile colitis 16.36 9.88 66 382491 20503 63085962
Glomerulonephritis minimal lesion 16.30 9.88 13 382544 242 63106223
Electrocardiogram QRS complex prolonged 16.29 9.88 75 382482 5863 63100602
Female genital tract fistula 16.25 9.88 13 382544 7546 63098919
Spinal fracture 16.24 9.88 56 382501 18215 63088250
Erythema multiforme 16.23 9.88 111 382446 10058 63096407
Atrial tachycardia 16.12 9.88 3 382554 4237 63102228
Skin papilloma 16.11 9.88 66 382491 4903 63101562
pH body fluid decreased 16.03 9.88 6 382551 20 63106445
Accidental exposure to product by child 15.92 9.88 27 382530 1166 63105299
Glomerulonephritis acute 15.85 9.88 9 382548 92 63106373
Pulmonary mass 15.85 9.88 76 382481 22520 63083945
Ulcer 15.85 9.88 233 382324 25874 63080591
Hepatic infiltration eosinophilic 15.81 9.88 6 382551 21 63106444
Nephritis allergic 15.62 9.88 12 382545 211 63106254
Fistula 15.61 9.88 24 382533 10369 63096096
Psychogenic tremor 15.60 9.88 6 382551 22 63106443
Pulmonary toxicity 15.57 9.88 104 382453 9351 63097114
Alanine aminotransferase abnormal 15.54 9.88 61 382496 4443 63102022
Pituitary tumour benign 15.51 9.88 36 382521 1959 63104506
Congestive cardiomyopathy 15.47 9.88 9 382548 6173 63100292
Dystonia 15.46 9.88 38 382519 13781 63092684
Conjunctival hyperaemia 15.38 9.88 40 382517 2339 63104126
Hallucination, auditory 15.36 9.88 34 382523 12790 63093675
Trichiasis 15.34 9.88 8 382549 68 63106397
Muscle tone disorder 15.31 9.88 10 382547 134 63106331
Pneumonitis 15.28 9.88 137 382420 35085 63071380
Atrial flutter 15.23 9.88 22 382535 9750 63096715
Adrenal insufficiency 15.20 9.88 56 382501 17859 63088606
Drug abuse 15.18 9.88 557 382000 71961 63034504
Focal peritonitis 15.16 9.88 5 382552 10 63106455
Blood copper decreased 15.16 9.88 5 382552 10 63106455
Drug dose omission by device 15.15 9.88 5 382552 4796 63101669
Orbital compartment syndrome 15.15 9.88 8 382549 70 63106395
Escherichia infection 15.13 9.88 34 382523 12720 63093745
Fear of injection 15.09 9.88 84 382473 7080 63099385
Genital pain 15.08 9.88 16 382541 435 63106030
SJS-TEN overlap 15.06 9.88 15 382542 378 63106087
Intentional product misuse 15.05 9.88 477 382080 60440 63046025
Pneumonia fungal 15.04 9.88 7 382550 5448 63101017
Anoxia 15.02 9.88 12 382545 224 63106241
Selenium deficiency 15.00 9.88 6 382551 25 63106440
Erosive duodenitis 15.00 9.88 16 382541 438 63106027
Fear of disease 14.98 9.88 28 382529 1306 63105159
Haemorrhage 14.95 9.88 268 382289 60754 63045711
Superior sagittal sinus thrombosis 14.91 9.88 21 382536 770 63105695
Papillitis 14.82 9.88 6 382551 26 63106439
Abdominal tenderness 14.78 9.88 92 382465 8074 63098391
Encephalopathy 14.73 9.88 155 382402 38465 63068000
Tendon disorder 14.72 9.88 72 382485 5771 63100694
Therapy partial responder 14.71 9.88 26 382531 10632 63095833
Hypertonia neonatal 14.66 9.88 12 382545 232 63106233
Anaphylactic reaction 14.64 9.88 511 382046 65589 63040876
Chronic sinusitis 14.62 9.88 35 382522 12808 63093657
Dyspareunia 14.58 9.88 40 382517 2415 63104050
Arthropathy 14.55 9.88 1622 380935 233170 62873295
Toxic encephalopathy 14.54 9.88 11 382546 6568 63099897
Normochromic anaemia 14.53 9.88 13 382544 285 63106180
Hypogammaglobulinaemia 14.53 9.88 13 382544 7142 63099323
Mediastinal abscess 14.47 9.88 6 382551 28 63106437
Necrotising colitis 14.44 9.88 18 382539 585 63105880
Product administration error 14.43 9.88 202 382355 22195 63084270
Joint destruction 14.41 9.88 10 382547 6242 63100223
Oesophageal discomfort 14.38 9.88 11 382546 192 63106273
Device occlusion 14.32 9.88 14 382543 7373 63099092
Grief reaction 14.28 9.88 12 382545 241 63106224
Device leakage 14.28 9.88 13 382544 7083 63099382
COVID-19 14.27 9.88 547 382010 112556 62993909
Prescribed overdose 14.26 9.88 287 382270 33866 63072599
Salivary gland cyst 14.25 9.88 4 382553 3 63106462
Blood iron abnormal 14.20 9.88 3 382554 3873 63102592
Circulatory collapse 14.19 9.88 198 382359 21740 63084725
Asphyxia 14.10 9.88 10 382547 6171 63100294
Tremor 14.07 9.88 652 381905 131587 62974878
Lymphoma 14.04 9.88 33 382524 12154 63094311
Paraesthesia 14.01 9.88 1113 381444 155853 62950612
Duodenal ulcer repair 14.00 9.88 7 382550 54 63106411
Evans syndrome 13.96 9.88 11 382546 201 63106264
Subarachnoid haemorrhage 13.93 9.88 42 382515 14241 63092224
Drug-induced liver injury 13.92 9.88 329 382228 39893 63066572
Thrombophlebitis septic 13.92 9.88 10 382547 158 63106307
Weight decreased 13.85 9.88 1458 381099 275340 62831125
Tissue infiltration 13.83 9.88 18 382539 611 63105854
Blood test abnormal 13.83 9.88 48 382509 15581 63090884
Personality disorder 13.79 9.88 9 382548 5802 63100663
Allergic respiratory disease 13.75 9.88 8 382549 86 63106379
Vulvovaginitis trichomonal 13.75 9.88 5 382552 15 63106450
Renal ischaemia 13.74 9.88 18 382539 615 63105850
Upper gastrointestinal perforation 13.72 9.88 4 382553 4 63106461
Needle issue 13.71 9.88 26 382531 10350 63096115
Staphylococcal scalded skin syndrome 13.69 9.88 9 382548 122 63106343
Acidosis 13.65 9.88 115 382442 11118 63095347
Product substitution issue 13.57 9.88 50 382507 15946 63090519
Listless 13.55 9.88 43 382514 2817 63103648
Cystitis haemorrhagic 13.54 9.88 4 382553 4119 63102346
Coagulopathy 13.53 9.88 186 382371 20358 63086107
Ludwig angina 13.52 9.88 8 382549 89 63106376
Alveolar rhabdomyosarcoma 13.51 9.88 5 382552 16 63106449
Atrioventricular block complete 13.43 9.88 18 382539 8233 63098232
Haemorrhage intracranial 13.42 9.88 39 382518 13380 63093085
Wheelchair user 13.42 9.88 11 382546 6308 63100157
Chromaturia 13.41 9.88 157 382400 16560 63089905
Pregnancy with contraceptive device 13.41 9.88 60 382497 4634 63101831
Disseminated intravascular coagulation 13.41 9.88 64 382493 18987 63087478
Costovertebral angle tenderness 13.37 9.88 8 382549 91 63106374
Small intestinal stenosis 13.37 9.88 17 382540 564 63105901
Splenic vein thrombosis 13.36 9.88 13 382544 318 63106147
Urogenital haemorrhage 13.34 9.88 12 382545 265 63106200
Laryngeal dyspnoea 13.30 9.88 10 382547 170 63106295
Genitourinary symptom 13.28 9.88 7 382550 61 63106404
Alpha 1 microglobulin increased 13.28 9.88 7 382550 61 63106404
Coronavirus infection 13.23 9.88 56 382501 4222 63102243
Pseudomonas infection 13.21 9.88 30 382527 11183 63095282
Tuberculosis 13.20 9.88 30 382527 11181 63095284
Upper limb fracture 13.18 9.88 64 382493 18904 63087561
Hyperuricaemia 13.18 9.88 8 382549 5362 63101103
Orthopnoea 13.17 9.88 11 382546 6250 63100215
No adverse event 13.16 9.88 173 382384 41232 63065233
Hyperacusis 13.13 9.88 35 382522 2078 63104387
Prescribed underdose 13.09 9.88 115 382442 29574 63076891
Palmar-plantar erythrodysaesthesia syndrome 13.08 9.88 83 382474 22932 63083533
Hyperventilation 13.08 9.88 72 382485 6044 63100421
Hepatitis acute 13.07 9.88 97 382460 9023 63097442
Transient ischaemic attack 13.02 9.88 155 382402 37598 63068867
Total bile acids increased 12.98 9.88 9 382548 134 63106331
Sinus node dysfunction 12.94 9.88 6 382551 4679 63101786
Vulval ulceration 12.91 9.88 13 382544 332 63106133
Hypothyroidism 12.87 9.88 180 382377 42452 63064013
Pulmonary valve disease 12.86 9.88 5 382552 19 63106446
Neuroleptic malignant syndrome 12.83 9.88 34 382523 12022 63094443
Forced expiratory volume decreased 12.76 9.88 7 382550 4961 63101504
Hyperlactacidaemia 12.75 9.88 42 382515 2807 63103658
Benzodiazepine drug level increased 12.73 9.88 10 382547 182 63106283
Pasteurella infection 12.72 9.88 7 382550 67 63106398
Therapeutic response decreased 12.72 9.88 278 382279 61247 63045218
Nerve injury 12.71 9.88 103 382454 9843 63096622
Tremor neonatal 12.70 9.88 9 382548 139 63106326
Substance abuser 12.66 9.88 5 382552 20 63106445
Cross sensitivity reaction 12.62 9.88 35 382522 2127 63104338
Adenovirus infection 12.61 9.88 3 382554 3568 63102897
Colitis 12.57 9.88 211 382346 48317 63058148
Schizoaffective disorder 12.56 9.88 3 382554 3559 63102906
Catheterisation cardiac 12.55 9.88 6 382551 4597 63101868
Small intestine ulcer 12.54 9.88 13 382544 344 63106121
Drug ineffective for unapproved indication 12.47 9.88 138 382419 33925 63072540
Pyoderma streptococcal 12.47 9.88 4 382553 7 63106458
Epistaxis 12.46 9.88 338 382219 72387 63034078
Glycosylated haemoglobin increased 12.43 9.88 36 382521 12362 63094103
Throat tightness 12.42 9.88 215 382342 24672 63081793
Facial spasm 12.36 9.88 18 382539 681 63105784
Peritonitis bacterial 12.35 9.88 7 382550 4872 63101593
Foetal non-stress test 12.35 9.88 3 382554 0 63106465
Laryngeal web 12.35 9.88 3 382554 0 63106465
Barbiturates positive 12.35 9.88 3 382554 0 63106465
Anastomotic ulcer perforation 12.35 9.88 3 382554 0 63106465
Microsleep 12.35 9.88 3 382554 0 63106465
Corrosive gastritis 12.35 9.88 3 382554 0 63106465
Chemical burn 12.34 9.88 14 382543 411 63106054
COVID-19 pneumonia 12.33 9.88 44 382513 14165 63092300
Enanthema 12.32 9.88 14 382543 412 63106053
Upper-airway cough syndrome 12.31 9.88 32 382525 11386 63095079
Emphysema 12.30 9.88 30 382527 10908 63095557
Streptococcal endocarditis 12.25 9.88 6 382551 44 63106421
Anti-thyroid antibody positive 12.21 9.88 14 382543 416 63106049
Substance dependence 12.19 9.88 10 382547 194 63106271
Gastric haemorrhage 12.16 9.88 73 382484 6325 63100140
Head injury 12.13 9.88 106 382451 27290 63079175
Henoch-Schonlein purpura nephritis 12.11 9.88 5 382552 23 63106442
Renal tubular necrosis 12.08 9.88 117 382440 11761 63094704
Pancreatic carcinoma 12.06 9.88 17 382540 7611 63098854
Inappropriate antidiuretic hormone secretion 12.05 9.88 50 382507 15412 63091053
Base excess 12.05 9.88 7 382550 75 63106390
Dermatitis atopic 12.05 9.88 100 382457 9624 63096841
Localised infection 12.03 9.88 120 382437 30090 63076375
Acquired haemophilia 12.03 9.88 22 382535 1009 63105456
Subdural haematoma 12.02 9.88 45 382512 14283 63092182
Quadriparesis 11.99 9.88 33 382524 1996 63104469
Osteochondrosis 11.99 9.88 26 382531 1351 63105114
Blood pressure diastolic abnormal 11.98 9.88 46 382511 14496 63091969
Delusion 11.97 9.88 35 382522 11982 63094483
Human papilloma virus test positive 11.94 9.88 16 382541 559 63105906
Narrow anterior chamber angle 11.92 9.88 6 382551 47 63106418
Blood pressure systolic abnormal 11.92 9.88 41 382516 13345 63093120
Brain injury 11.92 9.88 78 382479 6965 63099500
Autoimmune hepatitis 11.91 9.88 90 382467 8420 63098045
Retroplacental haematoma 11.87 9.88 9 382548 155 63106310
Gastric infection 11.85 9.88 47 382510 3440 63103025
Atypical femur fracture 11.85 9.88 9 382548 5363 63101102
Thyroid stimulating immunoglobulin increased 11.82 9.88 7 382550 78 63106387
Hyperchromic anaemia 11.81 9.88 6 382551 48 63106417
Lice infestation 11.81 9.88 4 382553 9 63106456
Generalised oedema 11.81 9.88 52 382505 15766 63090699
Strawberry tongue 11.78 9.88 5 382552 25 63106440
Abnormal clotting factor 11.77 9.88 8 382549 115 63106350
Photophobia 11.75 9.88 160 382397 17475 63088990
Persistent depressive disorder 11.74 9.88 22 382535 1028 63105437
Basal ganglion degeneration 11.74 9.88 14 382543 434 63106031
Amniotic fluid volume decreased 11.72 9.88 15 382542 501 63105964
Polymenorrhagia 11.71 9.88 6 382551 49 63106416
Rash maculo-papular 11.69 9.88 263 382294 31633 63074832
Anion gap 11.62 9.88 25 382532 1292 63105173
Platelet aggregation decreased 11.62 9.88 5 382552 26 63106439
Medical diet 11.62 9.88 5 382552 26 63106439
Monoplegia 11.58 9.88 44 382513 3157 63103308
Allodynia 11.55 9.88 19 382538 800 63105665
Hypothermia 11.55 9.88 129 382428 13452 63093013
Anti-transglutaminase antibody 11.52 9.88 4 382553 10 63106455
Nuchal rigidity 11.50 9.88 17 382540 652 63105813
Rhinorrhoea 11.44 9.88 304 382253 65273 63041192
Peripheral sensory neuropathy 11.39 9.88 17 382540 7434 63099031
Glomerulonephropathy 11.38 9.88 7 382550 84 63106381
International normalised ratio increased 11.34 9.88 204 382353 46221 63060244
Sinus disorder 11.32 9.88 94 382463 24459 63082006
Skin test negative 11.25 9.88 4 382553 11 63106454
Pneumoperitoneum 11.18 9.88 26 382531 1417 63105048
Mouth ulceration 11.16 9.88 136 382421 32848 63073617
Low birth weight baby 11.16 9.88 16 382541 7113 63099352
Ischaemic stroke 11.13 9.88 63 382494 17894 63088571
Granuloma 11.12 9.88 66 382491 5695 63100770
Electrolyte imbalance 11.10 9.88 73 382484 20003 63086462
Systemic mastocytosis 11.09 9.88 9 382548 172 63106293
Nasal polyps 11.08 9.88 12 382545 6027 63100438
Haemoptysis 11.07 9.88 115 382442 28611 63077854
Xanthoma 11.03 9.88 6 382551 56 63106409
Allergy test positive 11.01 9.88 16 382541 604 63105861
Eosinophilia 11.00 9.88 86 382471 22670 63083795
Alanine aminotransferase increased 10.99 9.88 746 381811 103024 63003441
Lupus-like syndrome 10.99 9.88 51 382506 15244 63091221
Caesarean section 10.97 9.88 59 382498 16973 63089492
Carotid artery dissection 10.96 9.88 9 382548 175 63106290
Eye infection 10.95 9.88 37 382520 12108 63094357
Anal haemorrhage 10.94 9.88 33 382524 2103 63104362
Suicidal ideation 10.86 9.88 470 382087 61951 63044514
Abscess rupture 10.86 9.88 11 382546 283 63106182
Transverse sinus thrombosis 10.79 9.88 15 382542 543 63105922
Hepatobiliary scan abnormal 10.77 9.88 6 382551 59 63106406
Inflammatory bowel disease 10.77 9.88 50 382507 3923 63102542
Neonatal hypoxia 10.72 9.88 16 382541 619 63105846
Bone loss 10.72 9.88 42 382515 3057 63103408
Clostridium test positive 10.71 9.88 3 382554 3198 63103267
Gastrooesophageal reflux disease 10.69 9.88 469 382088 95170 63011295
Vulval disorder 10.68 9.88 19 382538 853 63105612
Hallucination 10.67 9.88 250 382307 54567 63051898
Product storage error 10.67 9.88 50 382507 14906 63091559
Colitis ulcerative 10.66 9.88 103 382454 25988 63080477
Dialysis 10.65 9.88 30 382527 10397 63096068
Lymphoproliferative disorder 10.65 9.88 3 382554 3187 63103278
Oedema genital 10.62 9.88 9 382548 183 63106282
Oxygen saturation abnormal 10.58 9.88 4 382553 3525 63102940
Hepatic cancer 10.58 9.88 7 382550 4480 63101985
Flank pain 10.57 9.88 148 382409 16262 63090203
Lung opacity 10.54 9.88 3 382554 3165 63103300
Thyroid cancer 10.46 9.88 11 382546 5600 63100865
Gait deviation 10.43 9.88 6 382551 63 63106402
Blood lactate dehydrogenase increased 10.43 9.88 89 382468 23027 63083438
Vaginal ulceration 10.42 9.88 13 382544 423 63106042
Colon cancer 10.41 9.88 28 382529 9850 63096615
Hypokalaemia 10.40 9.88 515 382042 103289 63003176
Victim of abuse 10.40 9.88 7 382550 99 63106366
Coronary artery disease 10.39 9.88 135 382422 32242 63074223
Onychomycosis 10.37 9.88 20 382537 7912 63098553
Therapy non-responder 10.36 9.88 558 381999 75343 63031122
Chest wall abscess 10.35 9.88 6 382551 64 63106401
Akathisia 10.35 9.88 25 382532 9121 63097344
Syncope 10.33 9.88 590 381967 116795 62989670
Limbal stem cell deficiency 10.33 9.88 4 382553 15 63106450
Candida infection 10.33 9.88 115 382442 28236 63078229
Skin necrosis 10.31 9.88 129 382428 13821 63092644
Pleural fibrosis 10.30 9.88 4 382553 3468 63102997
Pharyngeal lesion 10.29 9.88 3 382554 3 63106462
Uraemic gastropathy 10.29 9.88 3 382554 3 63106462
Intestinal atony 10.29 9.88 3 382554 3 63106462
Meconium ileus 10.29 9.88 3 382554 3 63106462
Pulmonary pneumatocele 10.29 9.88 3 382554 3 63106462
Dermatitis bullous 10.28 9.88 87 382470 8421 63098044
Leukoencephalopathy 10.25 9.88 7 382550 4406 63102059
Blood glucose abnormal 10.23 9.88 20 382537 7872 63098593
Injection site pruritus 10.17 9.88 201 382356 44915 63061550
Heart rate increased 10.15 9.88 464 382093 93774 63012691
Myoglobin urine 10.13 9.88 4 382553 16 63106449
Treatment noncompliance 10.09 9.88 161 382396 37164 63069301
Speech disorder 10.09 9.88 178 382379 40451 63066014
Pemphigoid 10.06 9.88 18 382539 7326 63099139
Implant site pain 10.06 9.88 35 382522 2405 63104060
Glucose tolerance impaired 10.06 9.88 15 382542 6562 63099903
Lymphopenia 9.95 9.88 67 382490 18260 63088205
Wrist fracture 9.94 9.88 45 382512 13542 63092923
Breast cancer recurrent 9.93 9.88 7 382550 4334 63102131
Hyperthyroidism 9.92 9.88 50 382507 14623 63091842
Helicobacter gastritis 9.90 9.88 27 382530 1625 63104840