All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

hydroxyzine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
diphenylmethyl piperazine derivatives	1400	68-88-2

Description:

Molecule

Description

Molfile Inchi Smiles Synonyms: hydroxyzine pamoate hydroxizine hydroxyzin hydroxyzyne tranquizine hydroxyzine hydroxyzine hydrochloride hydroxyzine dihydrochloride hydroxyzine HCl

A histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. Unlike its major metabolite CETIRIZINE, it does cause drowsiness. It is also effective as an antiemetic, for relief of anxiety and tension, and as a sedative. Molecular weight: 374.91 Formula: C21H27ClN2O2 CLOGP: 4 LIPINSKI: 0 HAC: 4 HDO: 1 TPSA: 35.94 ALOGS: -3.61 ROTB: 8 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Drug dosage:

Dose	Unit	Route
75	mg	O
75	mg	P

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	700 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	0.10 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	15.24 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	80 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

Date	Agency	Company	Orphan
April 12, 1956	FDA	PFIZER

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	1037.68	10.03	1041	71625	144632	63271724
Intentional overdose	423.79	10.03	472	72194	73680	63342676
Toxicity to various agents	400.41	10.03	877	71789	246373	63169983
Intentional self-injury	343.05	10.03	263	72403	25424	63390932
Pruritus	300.48	10.03	1002	71664	360451	63055905
Dermatitis atopic	280.44	10.03	161	72505	9563	63406793
Drug abuse	274.12	10.03	375	72291	72143	63344213
Urticaria	261.06	10.03	582	72084	165220	63251136
Synovitis	179.94	10.03	8	72658	186910	63229446
Contraindicated product administered	179.03	10.03	20	72646	217628	63198728
Pemphigus	176.41	10.03	8	72658	183718	63232638
Systemic lupus erythematosus	164.95	10.03	22	72644	208896	63207460
Cardio-respiratory arrest	160.57	10.03	264	72402	59695	63356661
Hand deformity	156.23	10.03	6	72660	159451	63256905
Joint swelling	155.72	10.03	91	72575	327575	63088781
Glossodynia	150.78	10.03	15	72651	178861	63237495
Poisoning deliberate	143.50	10.03	112	72554	11106	63405250
Rheumatoid arthritis	136.24	10.03	60	72606	253759	63162597
Pericarditis	136	10.03	3	72663	131576	63284780
Respiratory arrest	131.17	10.03	174	72492	32471	63383885
Arthropathy	128.39	10.03	54	72612	234738	63181618
Treatment failure	122.01	10.03	38	72628	199005	63217351
Poisoning	121.98	10.03	111	72555	13589	63402767
Suicide attempt	118.02	10.03	233	72433	60685	63355671
Drug dependence	111.71	10.03	139	72527	24344	63392012
Drug intolerance	110.73	10.03	114	72552	308547	63107809
Skin plaque	108.44	10.03	84	72582	8236	63408120
Anxiety	107.31	10.03	513	72153	217028	63199328
Cardiac arrest	107.23	10.03	289	72377	92256	63324100
Wound	104.00	10.03	29	72637	163234	63253122
Abdominal discomfort	98.54	10.03	134	72532	320751	63095605
Infusion related reaction	95.84	10.03	84	72582	245437	63170919
Scratch	91.54	10.03	69	72597	6496	63409860
Hepatic enzyme increased	88.07	10.03	62	72604	202266	63214090
Therapeutic product effect decreased	85.68	10.03	58	72608	193129	63223227
Suicidal ideation	83.72	10.03	206	72460	62215	63354141
Helicobacter infection	83.03	10.03	6	72660	92779	63323577
Eczema	80.84	10.03	138	72528	32153	63384203
Suspected suicide	80.61	10.03	64	72602	6504	63409852
Anticholinergic syndrome	78.34	10.03	43	72623	2339	63414017
Urticaria thermal	77.11	10.03	26	72640	413	63415943
Somnolence	74.46	10.03	402	72264	178283	63238073
Drug reaction with eosinophilia and systemic symptoms	71.13	10.03	134	72532	33702	63382654
Distributive shock	68.82	10.03	33	72633	1350	63415006
Coma	68.59	10.03	195	72471	64169	63352187
Maternal exposure during pregnancy	67.39	10.03	92	72574	219970	63196386
Overdose	66.86	10.03	285	72381	114793	63301563
Alopecia	66.13	10.03	184	72482	337352	63079004
Psoriasis	63.99	10.03	232	72434	86725	63329631
Bradypnoea	62.52	10.03	43	72623	3507	63412849
Lower respiratory tract infection	62.38	10.03	37	72629	132270	63284086
Burning mouth syndrome	62.04	10.03	23	72643	488	63415868
Irritability	59.89	10.03	120	72546	31574	63384782
Chemical submission	58.76	10.03	19	72647	263	63416093
Folliculitis	54.05	10.03	8	72658	70309	63346047
Electrocardiogram QT prolonged	53.64	10.03	170	72496	59360	63356996
Angioedema	52.75	10.03	147	72519	47818	63368538
Muscle injury	51.24	10.03	7	72659	65338	63351018
Impaired healing	50.75	10.03	27	72639	102515	63313841
Depression	49.23	10.03	389	72277	196103	63220253
Prescription form tampering	48.84	10.03	20	72646	558	63415798
General physical health deterioration	47.96	10.03	99	72567	201303	63215053
Musculoskeletal stiffness	46.32	10.03	88	72578	184530	63231826
Vasoplegia syndrome	45.98	10.03	27	72639	1672	63414684
Product dose omission issue	45.24	10.03	438	72228	233875	63182481
Decompression sickness	45.20	10.03	12	72654	78	63416278
Urinary retention	41.67	10.03	101	72565	30200	63386156
Rash maculo-papular	41.42	10.03	104	72562	31792	63384564
Chronic spontaneous urticaria	41.15	10.03	22	72644	1135	63415221
Sleep disorder	39.87	10.03	192	72474	81374	63334982
Alcoholism	39.24	10.03	25	72641	1793	63414563
Product use in unapproved indication	38.70	10.03	343	72323	178737	63237619
Multiple drug therapy	37.37	10.03	32	72634	3614	63412742
Agitation	36.24	10.03	150	72516	59607	63356749
Intentional product misuse	36.23	10.03	152	72514	60765	63355591
Drug screen positive	35.47	10.03	31	72635	3598	63412758
Irritable bowel syndrome	34.85	10.03	26	72640	82386	63333970
Insomnia	34.28	10.03	387	72279	214865	63201491
Victim of chemical submission	33.67	10.03	15	72651	517	63415839
Parkinsonism	33.53	10.03	50	72616	10389	63405967
Hallucination, gustatory	33.20	10.03	9	72657	64	63416292
Dry skin	33.10	10.03	141	72525	56746	63359610
Asphyxia	32.96	10.03	38	72628	6143	63410213
Mastocytosis	32.28	10.03	15	72651	571	63415785
Drug ineffective	32.25	10.03	931	71735	1043834	62372522
Infection	32.04	10.03	144	72522	229029	63187327
Allergy test positive	31.48	10.03	15	72651	605	63415751
Illness	31.22	10.03	125	72541	48934	63367422
Skin exfoliation	30.85	10.03	114	72552	42988	63373368
Serotonin syndrome	30.64	10.03	87	72579	28595	63387761
Swelling	30.15	10.03	188	72478	275190	63141166
Long QT syndrome	30.04	10.03	27	72639	3252	63413104
Cerebral disorder	29.65	10.03	31	72635	4495	63411861
Stomatitis	29.10	10.03	73	72593	138652	63277704
Papule	28.70	10.03	34	72632	5657	63410699
Mixed liver injury	28.49	10.03	31	72635	4704	63411652
Faecal vomiting	28.42	10.03	14	72652	608	63415748
Hereditary angioedema	28.37	10.03	39	72627	7523	63408833
Drug hypersensitivity	28.24	10.03	506	72160	310181	63106175
Peripheral circulatory failure	27.83	10.03	16	72650	952	63415404
Red blood cell sedimentation rate increased	27.64	10.03	8	72658	43974	63372382
Hip arthroplasty	27.58	10.03	10	72656	47636	63368720
Metabolic acidosis	27.22	10.03	113	72553	44956	63371400
Withdrawal syndrome	26.80	10.03	66	72600	19931	63396425
Linear IgA disease	26.56	10.03	18	72648	1433	63414923
Migraine	26.07	10.03	205	72461	103141	63313215
Administration site erythema	25.68	10.03	14	72652	751	63415605
Seizure	25.11	10.03	247	72419	132387	63283969
Initial insomnia	25.00	10.03	33	72633	6124	63410232
Off label use	24.97	10.03	585	72081	673877	62742479
Erythema	24.45	10.03	308	72358	175443	63240913
Blood cholesterol increased	24.30	10.03	44	72622	93988	63322368
Respiratory acidosis	24.25	10.03	34	72632	6681	63409675
Mental disorder	24.24	10.03	75	72591	25844	63390512
Panic attack	24.11	10.03	68	72598	22263	63394093
Hallucination, visual	24.09	10.03	62	72604	19236	63397120
Exposure during pregnancy	24.05	10.03	94	72572	155453	63260903
Pulmonary fibrosis	23.66	10.03	8	72658	39801	63376555
Interstitial lung disease	23.14	10.03	22	72644	61886	63354470
Total cholesterol/HDL ratio abnormal	23.11	10.03	7	72659	77	63416279
Diet failure	22.60	10.03	6	72660	39	63416317
Hypersensitivity	22.58	10.03	220	72446	292465	63123891
Neuroglycopenia	22.56	10.03	11	72655	467	63415889
Labile hypertension	22.39	10.03	11	72655	475	63415881
Perfume sensitivity	22.33	10.03	13	72653	792	63415564
Dementia	22.05	10.03	59	72607	18735	63397621
Miosis	21.89	10.03	34	72632	7319	63409037
Knee arthroplasty	21.78	10.03	18	72648	54188	63362168
Product use issue	21.40	10.03	156	72510	220364	63195992
Skin fissures	21.37	10.03	43	72623	11345	63405011
Osteoarthritis	20.92	10.03	49	72617	95294	63321062
Psychotic symptom	20.86	10.03	16	72650	1545	63414811
Inappropriate schedule of product administration	20.85	10.03	196	72470	103769	63312587
Asthma	20.58	10.03	230	72436	127331	63289025
Nodular rash	20.47	10.03	8	72658	197	63416159
Neutropenia	20.44	10.03	117	72549	174888	63241468
Stress	20.23	10.03	139	72527	67028	63349328
Depressed level of consciousness	20.22	10.03	131	72535	61947	63354409
Akathisia	20.19	10.03	37	72629	9109	63407247
Feeling abnormal	20.19	10.03	259	72407	148133	63268223
Pancreatitis	20.14	10.03	110	72556	48945	63367411
Plasma cell myeloma	20.01	10.03	8	72658	35897	63380459
Injection site reaction	19.99	10.03	125	72541	58399	63357957
Lymphomatoid papulosis	19.85	10.03	7	72659	128	63416228
C-reactive protein increased	19.73	10.03	50	72616	94657	63321699
Binge eating	19.53	10.03	10	72656	472	63415884
Mast cell activation syndrome	19.45	10.03	12	72654	813	63415543
Injection site mass	19.36	10.03	56	72610	18600	63397756
Skin lesion	19.32	10.03	78	72588	30643	63385713
Toxic skin eruption	18.85	10.03	44	72622	12841	63403515
Dermatitis	18.66	10.03	52	72614	16906	63399450
Gastrointestinal disorder	18.61	10.03	82	72584	131157	63285199
Tremor	18.49	10.03	232	72434	132007	63284349
Substance abuse	18.35	10.03	25	72641	4782	63411574
Altered state of consciousness	18.28	10.03	67	72599	25163	63391193
Temperature intolerance	18.21	10.03	35	72631	8929	63407427
Sensitivity to weather change	18.20	10.03	31	72635	7206	63409150
Cold agglutinins positive	18.15	10.03	5	72661	38	63416318
Atrioventricular block first degree	18.09	10.03	31	72635	7242	63409114
Dermatitis exfoliative generalised	17.98	10.03	22	72644	3785	63412571
Blood cholesterol decreased	17.97	10.03	12	72654	932	63415424
Enuresis	17.53	10.03	18	72648	2555	63413801
Photosensitivity reaction	17.52	10.03	47	72619	14947	63401409
Anaemia	17.37	10.03	234	72432	293196	63123160
Pleural effusion	17.34	10.03	52	72614	93158	63323198
Disturbance in attention	17.30	10.03	88	72578	38101	63378255
Emotional distress	16.90	10.03	78	72588	32471	63383885
Intentional product use issue	16.89	10.03	82	72584	127810	63288546
Loss of personal independence in daily activities	16.88	10.03	56	72610	97234	63319122
Joint ankylosis	16.86	10.03	12	72654	1034	63415322
Liver injury	16.84	10.03	27	72639	60493	63355863
Talipes	16.78	10.03	14	72652	1526	63414830
Postural orthostatic tachycardia syndrome	16.77	10.03	13	72653	1276	63415080
Antidepressant discontinuation syndrome	16.76	10.03	5	72661	52	63416304
Therapeutic response shortened	16.75	10.03	40	72626	11848	63404508
Burnout syndrome	16.71	10.03	7	72659	207	63416149
Aggression	16.69	10.03	62	72604	23436	63392920
Drug interaction	16.69	10.03	361	72305	228770	63187586
Post-traumatic stress disorder	16.65	10.03	25	72641	5226	63411130
Pneumonia	16.63	10.03	397	72269	456370	62959986
Disease progression	16.63	10.03	78	72588	122680	63293676
Therapeutic product effect incomplete	16.62	10.03	80	72586	124976	63291380
Bursitis	16.56	10.03	11	72655	37030	63379326
Skin haemorrhage	16.47	10.03	36	72630	10058	63406298
Pneumonitis	16.38	10.03	10	72656	35212	63381144
Areflexia	16.34	10.03	19	72647	3099	63413257
Skin discolouration	16.33	10.03	86	72580	37742	63378614
Decreased eye contact	16.31	10.03	8	72658	344	63416012
Hyperleukocytosis	16.23	10.03	10	72656	676	63415680
Blood immunoglobulin E increased	16.20	10.03	21	72645	3828	63412528
Derailment	16.11	10.03	5	72661	60	63416296
Discomfort	15.95	10.03	119	72547	167255	63249101
Malignant neoplasm progression	15.86	10.03	45	72621	82076	63334280
Psoriatic arthropathy	15.66	10.03	53	72613	91467	63324889
Cholestasis	15.63	10.03	71	72595	29363	63386993
Myelosuppression	15.48	10.03	4	72662	23699	63392657
Encephalopathy	15.45	10.03	86	72580	38534	63377822
Fatigue	15.17	10.03	847	71819	887181	62529175
Thrombocytopenia	15.11	10.03	106	72560	151051	63265305
Dependence	15.01	10.03	15	72651	2062	63414294
Bipolar disorder	14.87	10.03	30	72636	7930	63408426
Neuroblastoma recurrent	14.80	10.03	5	72661	80	63416276
Drug withdrawal syndrome	14.74	10.03	66	72600	27128	63389228
Wound secretion	14.68	10.03	22	72644	4592	63411764
Tardive dyskinesia	14.65	10.03	31	72635	8471	63407885
Arthralgia	14.50	10.03	520	72146	569190	62847166
Bruxism	14.48	10.03	19	72647	3506	63412850
Macular degeneration	14.31	10.03	5	72661	24371	63391985
Blood pressure decreased	14.26	10.03	125	72541	64897	63351459
Ill-defined disorder	14.22	10.03	47	72619	81708	63334648
Wrong technique in device usage process	14.17	10.03	19	72647	3579	63412777
Musculoskeletal pain	14.10	10.03	56	72610	92221	63324135
Labelled drug-drug interaction issue	14.09	10.03	11	72655	1090	63415266
Bradykinesia	14.09	10.03	23	72643	5165	63411191
Ehlers-Danlos syndrome	14.06	10.03	6	72660	186	63416170
Superior mesenteric artery syndrome	14.05	10.03	5	72661	94	63416262
Urticaria chronic	13.99	10.03	9	72657	656	63415700
Sedation	13.95	10.03	84	72582	38725	63377631
Eye pruritus	13.88	10.03	50	72616	18621	63397735
Obsessive-compulsive disorder	13.84	10.03	20	72646	4040	63412316
Accidental overdose	13.73	10.03	58	72608	23251	63393105
Rash pruritic	13.66	10.03	116	72550	59683	63356673
Lip erythema	13.55	10.03	6	72660	204	63416152
Mydriasis	13.49	10.03	37	72629	11919	63404437
Blister	13.49	10.03	90	72576	129724	63286632
Thymoma	13.46	10.03	6	72660	207	63416149
Gastric polyps	13.44	10.03	18	72648	3387	63412969
Anaphylactic reaction	13.44	10.03	125	72541	65975	63350381
Panic reaction	13.42	10.03	20	72646	4154	63412202
Product dose omission in error	13.40	10.03	28	72638	7584	63408772
Apallic syndrome	13.33	10.03	9	72657	712	63415644
Alpha 1 globulin increased	13.32	10.03	5	72661	110	63416246
Pigmentation disorder	13.19	10.03	21	72645	4618	63411738
Atrial fibrillation	13.07	10.03	79	72587	116557	63299799
Human herpesvirus 6 infection reactivation	12.99	10.03	7	72659	367	63415989
Restless arm syndrome	12.97	10.03	4	72662	47	63416309
Eyelid haemangioma	12.93	10.03	3	72663	10	63416346
Transverse sinus thrombosis	12.86	10.03	8	72658	550	63415806
Tonsillar hypertrophy	12.81	10.03	10	72656	991	63415365
Dysuria	12.76	10.03	74	72592	33664	63382692
Skin infection	12.74	10.03	42	72624	14960	63401396
Granulomatous liver disease	12.71	10.03	9	72657	769	63415587
Psychiatric symptom	12.65	10.03	22	72644	5201	63411155
Superior sagittal sinus thrombosis	12.58	10.03	9	72657	782	63415574
Gastrointestinal haemorrhage	12.57	10.03	49	72617	81127	63335229
Osteonecrosis of jaw	12.53	10.03	13	72653	35110	63381246
Exposure via ingestion	12.45	10.03	16	72650	2893	63413463
Breast adenoma	12.39	10.03	4	72662	55	63416301
Adverse event	12.34	10.03	38	72628	67521	63348835
Live birth	12.31	10.03	7	72659	25623	63390733
Alpha 2 globulin increased	12.29	10.03	5	72661	137	63416219
Resting tremor	12.26	10.03	9	72657	814	63415542
Haemoglobin decreased	12.22	10.03	107	72559	145378	63270978
Hallucination, olfactory	12.21	10.03	6	72660	259	63416097
Crying	12.17	10.03	56	72610	23287	63393069
Therapy interrupted	12.15	10.03	71	72595	32384	63383972
Mucosal inflammation	12.08	10.03	22	72644	46906	63369450
Social anxiety disorder	12.06	10.03	7	72659	424	63415932
Incorrect dose administered	11.99	10.03	113	72553	59855	63356501
Skin swelling	11.73	10.03	17	72649	3442	63412914
Ventricular fibrillation	11.72	10.03	35	72631	11832	63404524
Micrognathia	11.66	10.03	6	72660	286	63416070
Hyperglycaemia	11.65	10.03	85	72581	41782	63374574
Fat necrosis	11.64	10.03	8	72658	652	63415704
COVID-19	11.63	10.03	188	72478	112915	63303441
Foot deformity	11.50	10.03	9	72657	27844	63388512
Nightmare	11.49	10.03	48	72618	19146	63397210
Lip oedema	11.48	10.03	18	72648	3906	63412450
Herpes zoster meningoencephalitis	11.43	10.03	6	72660	298	63416058
Eosinophilia	11.43	10.03	54	72612	22702	63393654
Mechanical urticaria	11.42	10.03	7	72659	469	63415887
Mood altered	11.40	10.03	40	72626	14703	63401653
Tension	11.35	10.03	16	72650	3159	63413197
Orbital oedema	11.34	10.03	6	72660	303	63416053
Negative thoughts	11.30	10.03	9	72657	918	63415438
Neuroblastoma	11.30	10.03	4	72662	74	63416282
Bronchial wall thickening	11.16	10.03	11	72655	1488	63414868
Ear swelling	11.14	10.03	11	72655	1490	63414866
Affect lability	11.12	10.03	33	72633	11118	63405238
Retrograde amnesia	11.10	10.03	7	72659	493	63415863
Micturition disorder	10.92	10.03	14	72652	2524	63413832
Type 2 diabetes mellitus	10.92	10.03	37	72629	63831	63352525
Staphylococcal skin infection	10.90	10.03	9	72657	966	63415390
Vascular stent thrombosis	10.89	10.03	9	72657	968	63415388
Caesarean section	10.88	10.03	3	72663	17029	63399327
Nasal congestion	10.86	10.03	119	72547	65541	63350815
Gastrointestinal ischaemia	10.84	10.03	5	72661	187	63416169
Hypotonia	10.74	10.03	29	72637	9256	63407100
Compulsive shopping	10.63	10.03	8	72658	751	63415605
Injection site pain	10.59	10.03	208	72458	129592	63286764
Tachycardia	10.55	10.03	192	72474	117964	63298392
White blood cell count decreased	10.52	10.03	105	72561	138999	63277357
Somnambulism	10.48	10.03	21	72645	5522	63410834
Oropharyngeal pain	10.45	10.03	159	72507	94328	63322028
Dysmorphism	10.41	10.03	13	72653	2283	63414073
Breath odour	10.41	10.03	10	72656	1310	63415046
Muscle spasticity	10.40	10.03	6	72660	21788	63394568
Lip swelling	10.39	10.03	66	72600	30997	63385359
Renal impairment	10.35	10.03	59	72607	88296	63328060
Bacterial disease carrier	10.34	10.03	10	72656	1321	63415035
Peripheral swelling	10.26	10.03	229	72437	265713	63150643
Hypercreatininaemia	10.25	10.03	7	72659	564	63415792
Vasculitis	10.24	10.03	4	72662	18205	63398151
Neurodermatitis	10.18	10.03	10	72656	1346	63415010
Activation syndrome	10.15	10.03	5	72661	217	63416139
Dyspnoea	10.14	10.03	637	72029	660676	62755680
Hair colour changes	10.07	10.03	15	72651	3112	63413244
Acidosis	10.04	10.03	32	72634	11201	63405155
Osteonecrosis	10.04	10.03	8	72658	24522	63391834

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	648.14	10.99	631	34143	97537	34824620
Toxicity to various agents	398.94	10.99	713	34061	199649	34722508
Drug abuse	260.14	10.99	400	34374	98696	34823461
Dermatitis atopic	201.78	10.99	101	34673	5246	34916911
Pruritus	126.39	10.99	368	34406	141613	34780544
Intentional overdose	105.61	10.99	170	34604	43504	34878653
Respiratory arrest	92.02	10.99	126	34648	27917	34894240
Coma	88.30	10.99	161	34613	45517	34876640
Poisoning	86.72	10.99	82	34692	12144	34910013
Cardio-respiratory arrest	86.31	10.99	178	34596	55095	34867062
Urticaria	64.57	10.99	171	34603	62206	34859951
Drug reaction with eosinophilia and systemic symptoms	62.07	10.99	115	34659	32897	34889260
Suicidal behaviour	58.60	10.99	29	34745	1468	34920689
Cardiac arrest	58.28	10.99	219	34555	95940	34826217
Intentional self-injury	57.93	10.99	70	34704	13701	34908456
Overdose	55.69	10.99	208	34566	90851	34831306
Priapism	52.64	10.99	42	34732	4952	34917205
Suspected suicide	52.35	10.99	41	34733	4707	34917450
Ventricular tachyarrhythmia	48.35	10.99	17	34757	357	34921800
Parasomnia	47.07	10.99	17	34757	387	34921770
General physical health deterioration	43.68	10.99	38	34736	128231	34793926
Toxic epidermal necrolysis	41.42	10.99	76	34698	21570	34900587
Sleep disorder	40.28	10.99	94	34680	31594	34890563
Hyperthermia	40.04	10.99	51	34723	10526	34911631
Bradypnoea	39.15	10.99	28	34746	2801	34919356
Dry skin	37.81	10.99	91	34683	31196	34890961
Ureteric compression	37.24	10.99	13	34761	267	34921890
Anticholinergic syndrome	36.52	10.99	20	34754	1249	34920908
Psoriasis	34.79	10.99	101	34673	38711	34883446
Chemical submission	33.89	10.99	8	34766	35	34922122
Alcoholism	33.55	10.99	26	34748	2939	34919218
Electrocardiogram QT prolonged	32.41	10.99	102	34672	40850	34881307
Somnolence	30.45	10.99	202	34572	110914	34811243
Rash	29.55	10.99	345	34429	222407	34699750
Personal relationship issue	28.91	10.99	11	34763	291	34921866
Exposure via ingestion	28.84	10.99	21	34753	2160	34919997
Suicidal ideation	28.72	10.99	97	34677	40291	34881866
Fixed eruption	28.66	10.99	19	34755	1681	34920476
Autism spectrum disorder	27.88	10.99	21	34753	2275	34919882
Drug dependence	27.73	10.99	69	34705	24148	34898009
Serotonin syndrome	27.40	10.99	61	34713	19872	34902285
Troponin T increased	27.28	10.99	21	34753	2350	34919807
Eczema	27.14	10.99	58	34716	18378	34903779
Disease progression	27.05	10.99	41	34733	108036	34814121
Abnormal sleep-related event	27.00	10.99	12	34762	475	34921682
Hypothermia	26.17	10.99	42	34732	10706	34911451
Skin exfoliation	26.15	10.99	73	34701	27359	34894798
Diarrhoea	25.76	10.99	256	34518	389656	34532501
Agitation	25.54	10.99	119	34655	57280	34864877
Face oedema	25.35	10.99	43	34731	11473	34910684
Mental disorder	24.92	10.99	50	34724	15159	34906998
Sensory integrative dysfunction	23.85	10.99	6	34768	36	34922121
Non-cardiogenic pulmonary oedema	23.51	10.99	12	34762	649	34921508
Emotional disorder of childhood	23.43	10.99	6	34768	39	34922118
Miosis	22.86	10.99	37	34737	9498	34912659
Clonus	22.53	10.99	20	34754	2730	34919427
Pyelocaliectasis	22.44	10.99	14	34760	1116	34921041
Electrocardiogram QRS complex prolonged	22.43	10.99	26	34748	4868	34917289
Disturbance in attention	21.80	10.99	66	34708	25879	34896278
Postmortem blood drug level	21.71	10.99	8	34766	193	34921964
Myocardial infarction	21.62	10.99	56	34718	121029	34801128
Acute generalised exanthematous pustulosis	21.54	10.99	30	34744	6746	34915411
Injection site reaction	21.53	10.99	43	34731	12990	34909167
Dermatitis exfoliative generalised	20.99	10.99	22	34752	3685	34918472
Tachyphrenia	20.95	10.99	14	34760	1255	34920902
Pneumonia	20.75	10.99	246	34528	362381	34559776
Haematoma muscle	20.00	10.99	14	34760	1354	34920803
Injection	19.62	10.99	4	34770	7	34922150
Poisoning deliberate	19.58	10.99	31	34743	7813	34914344
Mumps	19.52	10.99	6	34768	81	34922076
Skin fissures	19.34	10.99	25	34749	5234	34916923
Stereotypy	19.24	10.99	11	34763	747	34921410
Anaemia	19.00	10.99	145	34629	233190	34688967
Phlebotomy	18.76	10.99	6	34768	93	34922064
Distributive shock	18.72	10.99	13	34761	1241	34920916
Febrile bone marrow aplasia	18.53	10.99	31	34743	8178	34913979
Depressed level of consciousness	18.45	10.99	88	34686	42753	34879404
Echolalia	18.41	10.99	8	34766	300	34921857
False positive investigation result	18.36	10.99	9	34765	446	34921711
Drug withdrawal syndrome	18.14	10.99	52	34722	19782	34902375
Altered state of consciousness	18.09	10.99	57	34717	22836	34899321
Panic attack	17.89	10.99	33	34741	9399	34912758
Injection site mass	17.67	10.99	27	34747	6599	34915558
Conjunctivitis	17.22	10.99	33	34741	9672	34912485
Cardiac pacemaker evaluation	17.15	10.99	6	34768	124	34922033
Eosinophilia	16.92	10.99	61	34713	26161	34895996
Anxiety	16.90	10.99	162	34612	99266	34822891
Bladder dilatation	16.70	10.99	13	34761	1479	34920678
Discomfort	16.69	10.99	49	34725	18889	34903268
Agoraphobia	16.56	10.99	7	34767	245	34921912
Drug screen positive	16.51	10.99	20	34754	3923	34918234
Tachycardia	16.37	10.99	142	34632	84630	34837527
Respiratory depression	16.24	10.99	44	34730	16201	34905956
Cerebrovascular accident	16.09	10.99	38	34736	84773	34837384
Rheumatoid arthritis	16.08	10.99	9	34765	38229	34883928
Diarrhoea infectious	16.06	10.99	9	34765	588	34921569
Rash erythematous	16.03	10.99	58	34716	24919	34897238
Dissociation	15.49	10.99	13	34761	1645	34920512
Analgesic drug level increased	15.49	10.99	10	34764	846	34921311
Hypercapnic coma	15.35	10.99	6	34768	171	34921986
Dissociative disorder	15.20	10.99	8	34766	461	34921696
N-terminal prohormone brain natriuretic peptide increased	15.17	10.99	16	34758	2699	34919458
Intentional product misuse	15.04	10.99	87	34687	45524	34876633
Benzodiazepine drug level increased	14.79	10.99	4	34770	33	34922124
Atrial fibrillation	14.78	10.99	67	34707	122326	34799831
Acute respiratory distress syndrome	14.76	10.99	58	34716	25911	34896246
Administration related reaction	14.54	10.99	5	34769	98	34922059
Cardiac failure congestive	14.48	10.99	39	34735	83231	34838926
Infective pulmonary exacerbation of cystic fibrosis	14.45	10.99	25	34749	6776	34915381
Tremor	14.25	10.99	135	34639	82452	34839705
Cardiac failure	14.23	10.99	45	34729	91203	34830954
Thyroiditis acute	14.09	10.99	5	34769	108	34922049
C-reactive protein increased	14.04	10.99	20	34754	54078	34868079
Victim of crime	13.76	10.99	7	34767	376	34921781
Prothrombin time ratio decreased	13.66	10.99	7	34767	382	34921775
Aplastic anaemia	13.65	10.99	30	34744	9686	34912471
Victim of homicide	13.40	10.99	5	34769	125	34922032
Rash maculo-papular	13.40	10.99	60	34714	28391	34893766
Thrombocytopenia	13.22	10.99	96	34678	156151	34766006
Throat tightness	13.12	10.99	27	34747	8331	34913826
Neonatal respiratory distress	13.12	10.99	8	34766	612	34921545
Renal impairment	13.12	10.99	49	34725	94464	34827693
Neurodevelopmental disorder	12.89	10.99	7	34767	430	34921727
Meningioma	12.88	10.99	11	34763	1425	34920732
Faecal vomiting	12.81	10.99	7	34767	435	34921722
Generalised oedema	12.80	10.99	34	34740	12374	34909783
Mixed dementia	12.74	10.99	6	34768	272	34921885
Psychotic disorder	12.61	10.99	53	34721	24399	34897758
Neuroblastoma recurrent	12.46	10.99	5	34769	153	34922004
Arthritis allergic	12.38	10.99	3	34771	15	34922142
Speech disorder developmental	12.35	10.99	13	34761	2187	34919970
Pupillary reflex impaired	12.35	10.99	11	34763	1508	34920649
Haematoma	12.34	10.99	5	34769	25600	34896557
Neuropathy peripheral	12.33	10.99	42	34732	83221	34838936
Neurosis	12.31	10.99	5	34769	158	34921999
Hyponatraemia	12.05	10.99	42	34732	82649	34839508
Insomnia	12.03	10.99	157	34617	103750	34818407
Engraftment syndrome	11.84	10.99	9	34765	988	34921169
Drug screen false positive	11.83	10.99	8	34766	731	34921426
Cell death	11.61	10.99	13	34761	2344	34919813
Cardiogenic shock	11.58	10.99	6	34768	26612	34895545
Pharyngeal dyskinesia	11.40	10.99	3	34771	22	34922135
Allergy to chemicals	11.29	10.99	4	34770	86	34922071
Dyspnoea exertional	11.23	10.99	16	34758	43263	34878894
Neuroblastoma	11.23	10.99	5	34769	199	34921958
Lower respiratory tract infection	11.21	10.99	9	34765	31628	34890529
Skin plaque	11.19	10.99	18	34756	4596	34917561
Reduced facial expression	11.13	10.99	9	34765	1082	34921075
Acute myocardial infarction	11.06	10.99	23	34751	53696	34868461

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	1624.90	9.99	1673	88122	244094	79410499
Toxicity to various agents	783.43	9.99	1565	88230	419975	79234618
Drug abuse	459.93	9.99	727	89068	161964	79492629
Intentional overdose	430.92	9.99	563	89232	105397	79549196
Pruritus	311.51	9.99	1064	88731	393584	79261009
Urticaria	307.75	9.99	658	89137	184543	79470050
Dermatitis atopic	304.70	9.99	171	89624	9885	79644708
Intentional self-injury	269.69	9.99	251	89544	32168	79622425
Cardio-respiratory arrest	231.24	9.99	428	89367	108082	79546511
Respiratory arrest	215.69	9.99	294	89501	57256	79597337
Poisoning	212.77	9.99	197	89598	25075	79629518
Cardiac arrest	151.44	9.99	482	89313	171614	79482979
Poisoning deliberate	149.34	9.99	142	89653	18686	79635907
Coma	144.95	9.99	338	89457	100311	79554282
Synovitis	140.56	9.99	7	89788	150727	79503866
Suspected suicide	124.74	9.99	100	89695	10476	79644117
Drug reaction with eosinophilia and systemic symptoms	121.52	9.99	241	89554	64003	79590590
Joint swelling	118.48	9.99	91	89704	288555	79366038
Anticholinergic syndrome	113.73	9.99	63	89732	3548	79651045
Suicide attempt	113.42	9.99	273	89522	82659	79571934
Skin plaque	104.75	9.99	91	89704	10654	79643939
Rheumatoid arthritis	104.55	9.99	52	89743	208418	79446175
Contraindicated product administered	99.69	9.99	27	89768	157511	79497082
Overdose	98.61	9.99	440	89355	183766	79470827
Bradypnoea	97.57	9.99	69	89726	5983	79648610
Somnolence	97.35	9.99	528	89267	238453	79416140
Drug dependence	95.94	9.99	168	89627	40601	79613992
Pericarditis	93.60	9.99	6	89789	104230	79550363
Hand deformity	93.26	9.99	6	89789	103913	79550680
Chemical submission	88.53	9.99	27	89768	310	79654283
Arthropathy	86.09	9.99	46	89749	177065	79477528
Distributive shock	82.23	9.99	46	89749	2641	79651952
Pemphigus	80.49	9.99	9	89786	99573	79555020
Urticaria thermal	77.18	9.99	26	89769	419	79654174
Eczema	77.03	9.99	153	89642	40665	79613928
Anxiety	76.84	9.99	511	89284	248001	79406592
General physical health deterioration	76.27	9.99	120	89675	275118	79379475
Systemic lupus erythematosus	76.20	9.99	21	89774	121128	79533465
Glossodynia	74.93	9.99	13	89782	103324	79551269
Scratch	71.95	9.99	66	89729	8297	79646296
Treatment failure	70.87	9.99	53	89742	170433	79484160
Drug intolerance	70.51	9.99	118	89677	264001	79390592
Serotonin syndrome	63.46	9.99	150	89645	44877	79609716
Lower respiratory tract infection	60.70	9.99	35	89760	129185	79525408
Burning mouth syndrome	60.64	9.99	23	89772	530	79654063
Electrocardiogram QT prolonged	58.57	9.99	229	89566	90157	79564436
Therapeutic product effect decreased	57.20	9.99	60	89735	163803	79490790
Helicobacter infection	57.09	9.99	6	89789	69698	79584895
Infusion related reaction	55.94	9.99	109	89686	230128	79424465
Hepatic enzyme increased	55.08	9.99	75	89720	182535	79472058
Suicidal ideation	54.92	9.99	200	89595	76140	79578453
Wound	52.42	9.99	33	89762	116146	79538447
Alcoholism	52.18	9.99	39	89756	3684	79650909
Agitation	50.19	9.99	234	89561	99481	79555112
Rash maculo-papular	50.11	9.99	158	89637	55920	79598673
Suicidal behaviour	50.00	9.99	36	89759	3211	79651382
Intentional product misuse	49.14	9.99	225	89570	94940	79559653
Abdominal discomfort	48.59	9.99	134	89661	250593	79404000
Priapism	47.68	9.99	40	89755	4465	79650128
Dry skin	46.28	9.99	175	89620	67820	79586773
Decompression sickness	44.88	9.99	12	89783	82	79654511
Vasoplegia syndrome	44.25	9.99	35	89760	3595	79650998
Chronic spontaneous urticaria	43.12	9.99	23	89772	1201	79653392
Psoriasis	42.73	9.99	207	89588	89380	79565213
Anaemia	41	9.99	313	89482	444702	79209891
Drug hypersensitivity	40.37	9.99	514	89281	298402	79356191
Parasomnia	39.61	9.99	17	89778	544	79654049
Faecal vomiting	39.26	9.99	21	89774	1103	79653490
Cerebral disorder	38.74	9.99	39	89756	5499	79649094
Multiple drug therapy	38.67	9.99	34	89761	4044	79650549
Miosis	38.36	9.99	66	89729	15723	79638870
Musculoskeletal stiffness	38.19	9.99	88	89707	174920	79479673
Disturbance in attention	38.16	9.99	135	89660	50666	79603927
Exposure via ingestion	37.23	9.99	37	89758	5137	79649456
Insomnia	36.75	9.99	430	89365	244740	79409853
Impaired healing	36.73	9.99	27	89768	87628	79566965
Urinary retention	36.29	9.99	143	89652	56487	79598106
Irritability	35.91	9.99	115	89680	41029	79613564
Injection site reaction	35.64	9.99	139	89656	54646	79599947
Administration site erythema	35.59	9.99	14	89781	357	79654236
Ureteric compression	35.53	9.99	13	89782	270	79654323
Muscle injury	35.44	9.99	6	89789	48555	79606038
Dermatitis exfoliative generalised	35.01	9.99	42	89753	7199	79647394
Product dose omission issue	34.84	9.99	429	89366	247108	79407485
Maternal exposure during pregnancy	34.59	9.99	63	89732	136475	79518118
Skin exfoliation	34.39	9.99	138	89657	54962	79599631
Angioedema	34.35	9.99	173	89622	75862	79578731
Disease progression	33.89	9.99	101	89694	184261	79470332
Asphyxia	33.89	9.99	53	89742	11667	79642926
Pneumonia	33.67	9.99	532	89263	659714	78994879
Panic attack	33.39	9.99	80	89715	24136	79630457
Altered state of consciousness	33.38	9.99	117	89678	43705	79610888
Hallucination, gustatory	33.22	9.99	9	89786	65	79654528
Hyperthermia	32.11	9.99	66	89729	17971	79636622
Drug withdrawal syndrome	32.10	9.99	99	89696	34619	79619974
Depression	31.50	9.99	378	89417	216412	79438181
Electrocardiogram QRS complex prolonged	31.34	9.99	49	89746	10784	79643809
Peripheral circulatory failure	30.73	9.99	18	89777	1128	79653465
Drug screen positive	30.69	9.99	36	89759	6027	79648566
Mastocytosis	30.47	9.99	14	89781	528	79654065
Diarrhoea	29.98	9.99	759	89036	879730	78774863
Allergy test positive	29.42	9.99	15	89780	713	79653880
Exposure during pregnancy	29.03	9.99	43	89752	101089	79553504
C-reactive protein increased	28.86	9.99	64	89731	128963	79525630
Depressed level of consciousness	28.77	9.99	197	89598	96455	79558138
Fixed eruption	28.75	9.99	25	89770	2929	79651664
Pyelocaliectasis	28.62	9.99	16	89779	917	79653676
Injection site mass	28.17	9.99	67	89728	20117	79634476
Alopecia	27.78	9.99	150	89645	231205	79423388
Neuroblastoma recurrent	27.45	9.99	10	89785	205	79654388
Myelosuppression	27.24	9.99	6	89789	40290	79614303
Renal impairment	27.19	9.99	89	89706	157694	79496899
Victim of chemical submission	27.10	9.99	13	89782	541	79654052
Pulmonary fibrosis	27.07	9.99	8	89787	44104	79610489
Red blood cell sedimentation rate increased	27.00	9.99	9	89786	45933	79608660
Sleep disorder	26.93	9.99	177	89618	85500	79569093
Mental disorder	26.87	9.99	87	89708	31215	79623378
Infection	26.71	9.99	161	89634	241551	79413042
Irritable bowel syndrome	26.30	9.99	19	89776	62222	79592371
Eosinophilia	26.28	9.99	111	89684	45234	79609359
Skin fissures	25.87	9.99	50	89745	13023	79641570
Thrombocytopenia	25.62	9.99	184	89611	265075	79389518
Neutropenia	24.78	9.99	206	89589	287504	79367089
Folliculitis	24.61	9.99	16	89779	55364	79599229
Atrial fibrillation	24.48	9.99	127	89668	197759	79456834
Personal relationship issue	24.42	9.99	9	89786	191	79654402
Long QT syndrome	23.17	9.99	31	89764	5924	79648669
Off label use	23.15	9.99	813	88982	906402	78748191
Total cholesterol/HDL ratio abnormal	23.14	9.99	7	89788	78	79654515
Tachyphrenia	23.12	9.99	19	89776	2061	79652532
Respiratory depression	23.00	9.99	76	89719	27554	79627039
Tremor	22.73	9.99	292	89503	169791	79484802
Diet failure	22.70	9.99	6	89789	39	79654554
Psychotic symptom	22.65	9.99	21	89774	2676	79651917
Neuroglycopenia	22.60	9.99	11	89784	473	79654120
Neuroblastoma	22.47	9.99	9	89786	241	79654352
Initial insomnia	22.36	9.99	33	89762	6905	79647688
Therapeutic product effect incomplete	22.32	9.99	83	89712	141562	79513031
Erythema	22.18	9.99	364	89431	222926	79431667
Intentional product use issue	22.14	9.99	92	89703	152020	79502573
Arthritis allergic	22.04	9.99	5	89790	15	79654578
Haemoglobin decreased	21.97	9.99	153	89642	221966	79432627
Product use in unapproved indication	21.94	9.99	400	89395	249959	79404634
Pleural effusion	21.68	9.99	87	89708	145175	79509418
Perfume sensitivity	21.47	9.99	13	89782	866	79653727
Labile hypertension	21.29	9.99	11	89784	538	79654055
Toxic epidermal necrolysis	21.24	9.99	103	89692	44478	79610115
Feeling abnormal	21.14	9.99	273	89522	158926	79495667
Neuropathy peripheral	20.85	9.99	85	89710	141220	79513373
Papule	20.73	9.99	33	89762	7374	79647219
Withdrawal syndrome	20.71	9.99	72	89723	26782	79627811
Osteoarthritis	20.61	9.99	42	89753	87267	79567326
Drug resistance	20.44	9.99	11	89784	42202	79612391
Acute respiratory distress syndrome	20.42	9.99	101	89694	43966	79610627
Plasma cell myeloma	20.32	9.99	18	89777	53241	79601352
Urticaria chronic	20.26	9.99	11	89784	595	79653998
Sensitivity to weather change	20.03	9.99	34	89761	8013	79646580
Post-traumatic stress disorder	19.90	9.99	26	89769	4855	79649738
Gastrointestinal haemorrhage	19.88	9.99	92	89703	147627	79506966
Face oedema	19.63	9.99	73	89722	28063	79626530
Victim of crime	19.56	9.99	10	89785	478	79654115
Drug ineffective	19.34	9.99	1008	88787	1079905	78574688
Tachycardia	19.24	9.99	294	89501	177474	79477119
Cerebral infarction	19.22	9.99	14	89781	45662	79608931
Binge eating	19.17	9.99	10	89785	499	79654094
Blood cholesterol increased	19.15	9.99	41	89754	83679	79570914
Hallucination, visual	18.87	9.99	80	89715	32649	79621944
Mixed liver injury	18.83	9.99	32	89763	7546	79647047
Accidental overdose	18.54	9.99	91	89704	39490	79615103
Knee arthroplasty	18.54	9.99	13	89782	43235	79611358
Seizure	18.44	9.99	307	89488	188527	79466066
Cardiac failure congestive	18.40	9.99	90	89705	142312	79512281
Prothrombin time ratio decreased	18.37	9.99	12	89783	913	79653680
Toxic skin eruption	18.27	9.99	61	89734	22232	79632361
Injection	18.16	9.99	4	89791	10	79654583
Tardive dyskinesia	18.02	9.99	38	89757	10533	79644060
Febrile bone marrow aplasia	17.93	9.99	43	89752	12977	79641616
Hip arthroplasty	17.78	9.99	9	89786	35747	79618846
Illness	17.72	9.99	101	89694	46410	79608183
Respiratory acidosis	17.64	9.99	39	89756	11161	79643432
Myocardial infarction	17.64	9.99	128	89667	184001	79470592
Phlebotomy	17.62	9.99	6	89789	100	79654493
Hyperleukocytosis	17.56	9.99	18	89777	2592	79652001
Sedation	17.40	9.99	109	89686	51786	79602807
Skin lesion	17.37	9.99	93	89702	41751	79612842
Dementia	17.22	9.99	64	89731	24595	79629998
Nodular rash	17.14	9.99	8	89787	313	79654280
Cold agglutinins positive	17.11	9.99	5	89790	49	79654544
Parkinsonism	16.95	9.99	49	89746	16535	79638058
Blood creatinine increased	16.75	9.99	104	89691	154953	79499640
Temperature intolerance	16.67	9.99	35	89760	9670	79644923
Postmortem blood drug level	16.52	9.99	8	89787	340	79654253
False positive investigation result	16.37	9.99	12	89783	1100	79653493
Abnormal sleep-related event	16.37	9.99	11	89784	878	79653715
Troponin T increased	16.33	9.99	20	89775	3502	79651091
Injection site pain	16.13	9.99	220	89575	129618	79524975
Cardiac pacemaker evaluation	16.12	9.99	6	89789	131	79654462
Haematochezia	16.11	9.99	48	89747	87597	79566996
Mydriasis	16.02	9.99	50	89745	17593	79637000
Autism spectrum disorder	15.99	9.99	12	89783	1140	79653453
Haemorrhage	15.97	9.99	51	89744	91067	79563526
Dyspnoea	15.92	9.99	796	88999	856229	78798364
International normalised ratio increased	15.86	9.99	46	89749	84675	79569918
Malignant neoplasm progression	15.86	9.99	89	89706	135901	79518692
Photosensitivity reaction	15.74	9.99	56	89739	21071	79633522
Migraine	15.65	9.99	159	89636	87334	79567259
Prostate cancer	15.63	9.99	9	89786	33259	79621334
Inappropriate schedule of product administration	15.63	9.99	224	89571	133404	79521189
Pancytopenia	15.50	9.99	116	89679	165629	79488964
Polymicrogyria	15.30	9.99	3	89792	3	79654590
Aggression	15.24	9.99	104	89691	50854	79603739
Non-cardiogenic pulmonary oedema	15.23	9.99	13	89782	1486	79653107
Interstitial lung disease	15.23	9.99	70	89725	112530	79542063
White blood cell count decreased	15.22	9.99	137	89658	188151	79466442
Lip erythema	15.07	9.99	7	89788	271	79654322
Acute myocardial infarction	15.03	9.99	41	89754	76995	79577598
Hypercapnic coma	15.03	9.99	8	89787	416	79654177
Derailment	14.93	9.99	5	89790	79	79654514
Eye pruritus	14.88	9.99	54	89741	20516	79634077
Linear IgA disease	14.87	9.99	18	89777	3114	79651479
Blood immunoglobulin E increased	14.83	9.99	25	89770	5857	79648736
Substance abuse	14.75	9.99	35	89760	10491	79644102
Dissociative disorder	14.74	9.99	10	89785	811	79653782
Analgesic drug level increased	14.66	9.99	18	89777	3160	79651433
Cardiac failure	14.65	9.99	108	89687	154734	79499859
Dermatitis	14.61	9.99	55	89740	21266	79633327
Areflexia	14.60	9.99	24	89771	5510	79649083
Clonus	14.57	9.99	27	89768	6813	79647780
Poor feeding infant	14.50	9.99	6	89789	175	79654418
Dystonia	14.49	9.99	55	89740	21344	79633249
Alpha 1 globulin increased	14.33	9.99	5	89790	90	79654503
Pigmentation disorder	14.33	9.99	24	89771	5594	79648999
Cerebral haemorrhage	14.25	9.99	27	89768	57646	79596947
Affect lability	14.25	9.99	36	89759	11223	79643370
Wrong technique in device usage process	14.21	9.99	20	89775	4008	79650585
Ascites	14.16	9.99	41	89754	75521	79579072
Psoriatic arthropathy	14.13	9.99	43	89752	77956	79576637
Arthritis	14.05	9.99	74	89721	114806	79539787
Haematoma muscle	14.03	9.99	16	89779	2599	79651994
Pancreatitis	13.92	9.99	128	89667	68447	79586146
Gastric polyps	13.81	9.99	19	89776	3728	79650865
Bursitis	13.81	9.99	12	89783	35832	79618761
Aplastic anaemia	13.80	9.99	48	89747	17857	79636736
Osteonecrosis of jaw	13.80	9.99	17	89778	43209	79611384
Pneumonitis	13.76	9.99	30	89765	60830	79593763
Condition aggravated	13.68	9.99	445	89350	500679	79153914
Incorrect dose administered	13.58	9.99	139	89656	76491	79578102
Therapeutic response shortened	13.53	9.99	44	89751	15819	79638774
Postural orthostatic tachycardia syndrome	13.52	9.99	10	89785	930	79653663
Dysuria	13.50	9.99	101	89694	50850	79603743
Lymphomatoid papulosis	13.48	9.99	7	89788	346	79654247
Antidepressant discontinuation syndrome	13.44	9.99	4	89791	42	79654551
Rash erythematous	13.38	9.99	111	89684	57658	79596935
Encephalopathy	13.28	9.99	125	89670	67272	79587321
Rash pruritic	13.21	9.99	131	89664	71498	79583095
Leukopenia	13.18	9.99	77	89718	116436	79538157
Rash	13.17	9.99	786	89009	577572	79077021
Stomatitis	13.11	9.99	104	89691	146653	79507940
Mental status changes	13.10	9.99	124	89671	66835	79587758
Acute generalised exanthematous pustulosis	13.08	9.99	46	89749	17208	79637385
Injection site induration	13.07	9.99	32	89763	9787	79644806
Vasculitis	12.97	9.99	6	89789	25096	79629497
Restless arm syndrome	12.96	9.99	4	89791	48	79654545
Breast adenoma	12.46	9.99	4	89791	55	79654538
Clostridium difficile infection	12.39	9.99	18	89777	42667	79611926
Proteinuria	12.38	9.99	11	89784	32491	79622102
Pupillary reflex impaired	12.36	9.99	17	89778	3336	79651257
Bronchiectasis	12.12	9.99	5	89790	22381	79632212
Drug screen false positive	12.05	9.99	10	89785	1099	79653494
Loss of personal independence in daily activities	12.03	9.99	67	89728	102513	79552080
Thymoma	11.91	9.99	6	89789	278	79654315
Atrioventricular block first degree	11.90	9.99	36	89759	12455	79642138
Vaginal lesion	11.89	9.99	5	89790	152	79654441
Labelled drug-drug interaction issue	11.86	9.99	11	89784	1402	79653191
Arthralgia	11.80	9.99	525	89270	571278	79083315
Alpha 2 globulin increased	11.80	9.99	5	89790	155	79654438
Mixed dementia	11.77	9.99	6	89789	285	79654308
Transverse sinus thrombosis	11.70	9.99	8	89787	657	79653936
Steal syndrome	11.70	9.99	3	89792	17	79654576
Inflammation	11.68	9.99	60	89735	93693	79560900
Gastrointestinal disorder	11.67	9.99	85	89710	122120	79532473
Skin infection	11.63	9.99	46	89749	18199	79636394
Sensory integrative dysfunction	11.55	9.99	3	89792	18	79654575
Metastases to liver	11.50	9.99	9	89786	28305	79626288
Dyskinesia	11.44	9.99	88	89707	44685	79609908
Bladder dilatation	11.43	9.99	13	89782	2106	79652487
Mood altered	11.38	9.99	45	89750	17802	79636791
Neurodermatitis	11.37	9.99	10	89785	1190	79653403
Hallucination, olfactory	11.36	9.99	7	89788	481	79654112
Diabetic ketoacidosis	11.34	9.99	13	89782	34109	79620484
Victim of homicide	11.28	9.99	5	89790	173	79654420
Infective pulmonary exacerbation of cystic fibrosis	11.28	9.99	36	89759	12815	79641778
Cerebrovascular accident	11.28	9.99	116	89679	155176	79499417
Neoplasm progression	11.25	9.99	26	89769	51656	79602937
Antithrombin III decreased	11.21	9.99	7	89788	493	79654100
Rash pustular	11.16	9.99	33	89762	11278	79643315
Mast cell activation syndrome	11.13	9.99	8	89787	712	79653881
Anion gap	11.12	9.99	13	89782	2168	79652425
Transplant rejection	11.09	9.99	4	89791	19433	79635160
Apallic syndrome	11.09	9.99	9	89786	959	79653634
Emotional disorder of childhood	11.04	9.99	3	89792	22	79654571
Therapy non-responder	10.98	9.99	60	89735	92245	79562348
Burnout syndrome	10.96	9.99	6	89789	330	79654263
Tonsillar hypertrophy	10.93	9.99	11	89784	1551	79653042
Superior mesenteric artery syndrome	10.92	9.99	5	89790	187	79654406
Hypotension	10.90	9.99	603	89192	439714	79214879
Autonomic nervous system imbalance	10.79	9.99	19	89776	4611	79649982
Thyroiditis acute	10.70	9.99	5	89790	196	79654397
Panic reaction	10.68	9.99	19	89776	4646	79649947
Hypertensive crisis	10.68	9.99	5	89790	20765	79633828
Deep vein thrombosis	10.66	9.99	86	89709	120833	79533760
Akathisia	10.62	9.99	36	89759	13223	79641370
Rectal haemorrhage	10.57	9.99	47	89748	76253	79578340
Mental impairment	10.56	9.99	46	89749	18990	79635603
Fatigue	10.49	9.99	903	88892	928824	78725769
Febrile neutropenia	10.46	9.99	190	89605	230809	79423784
Live birth	10.46	9.99	4	89791	18740	79635853
Adenoidectomy	10.39	9.99	4	89791	96	79654497
Accidental poisoning	10.38	9.99	11	89784	1646	79652947
Human herpesvirus 6 infection reactivation	10.31	9.99	7	89788	568	79654025
Agoraphobia	10.28	9.99	7	89788	571	79654022
Wheezing	10.27	9.99	83	89712	116581	79538012
Unresponsive to stimuli	10.27	9.99	102	89693	55686	79598907
Wound secretion	10.26	9.99	22	89773	6166	79648427
Compulsive shopping	10.23	9.99	8	89787	808	79653785
Asthma	10.18	9.99	211	89584	134884	79519709
Hypocalcaemia	10.17	9.99	26	89769	49898	79604695
Food allergy	10.13	9.99	31	89764	10793	79643800
Inability to afford medication	10.13	9.99	14	89781	2759	79651834
Sensation of blood flow	10.10	9.99	4	89791	104	79654489
Cataract	10.04	9.99	36	89759	62084	79592509
Skin swelling	10.04	9.99	17	89778	3997	79650596
Dissociation	10.02	9.99	17	89778	4004	79650589
Blood cholesterol decreased	10.02	9.99	11	89784	1714	79652879

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Eyelid haemangioma	20.65	17.21	3	7	9	89773

Pharmacologic Action:

Source	Code	Description
ATC	N05BB01	NERVOUS SYSTEM PSYCHOLEPTICS ANXIOLYTICS Diphenylmethane derivatives
ATC	N05BB51	NERVOUS SYSTEM PSYCHOLEPTICS ANXIOLYTICS Diphenylmethane derivatives
FDA MoA	N0000000207	Histamine Receptor Antagonists
MeSH PA	D000982	Antipruritics
MeSH PA	D003879	Dermatologic Agents
MeSH PA	D018494	Histamine Agents
MeSH PA	D006633	Histamine Antagonists
MeSH PA	D006634	Histamine H1 Antagonists
MeSH PA	D018377	Neurotransmitter Agents
CHEBI has role	CHEBI:35474	anti-anxiety agents
CHEBI has role	CHEBI:37955	H1 receptor antagonists
CHEBI has role	CHEBI:50177	dermatologic agent
CHEBI has role	CHEBI:59683	antipruritic drugs
CHEBI has role	CHEBI:149553	anticoronaviral drug
FDA EPC	N0000175750	Antihistamine

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Dermatographic urticaria	indication	7632005	DOID:743
Atopic dermatitis	indication	24079001	DOID:3310
Allergic rhinitis	indication	61582004
Nasal discharge	indication	64531003
Urticaria	indication	126485001
Itching of skin	indication	418363000
Allergic conjunctivitis	indication	473460002	DOID:11204
Severe Pruritus	off-label use
Tachyarrhythmia	contraindication	6285003
Alcoholism	contraindication	7200002
Peptic ulcer	contraindication	13200003	DOID:750
Pulmonary edema	contraindication	19242006	DOID:11396
Myocardial infarction	contraindication	22298006	DOID:5844
Shock	contraindication	27942005
Hyperthyroidism	contraindication	34486009	DOID:7998
Acute hepatitis	contraindication	37871000
Hypertensive disorder	contraindication	38341003	DOID:10763
Hypothyroidism	contraindication	40930008	DOID:1459
Third trimester pregnancy	contraindication	41587001
Conduction disorder of the heart	contraindication	44808001
Chronic heart failure	contraindication	48447003
Disorder of cardiovascular system	contraindication	49601007	DOID:1287
Multiple organ failure	contraindication	57653000
Psychotic disorder	contraindication	69322001
Diabetes mellitus	contraindication	73211009	DOID:9351
Chronic idiopathic constipation	contraindication	82934008
Cor pulmonale	contraindication	83291003	DOID:8515
Open-angle glaucoma	contraindication	84494001	DOID:1067
Seizure disorder	contraindication	128613002
Cystic fibrosis	contraindication	190905008	DOID:1485
Angina pectoris	contraindication	194828000
Disease of liver	contraindication	235856003	DOID:409
Bladder outflow obstruction	contraindication	236645006
Sepsis syndrome	contraindication	238150007
Benign prostatic hyperplasia	contraindication	266569009
Retention of urine	contraindication	267064002
Continuous fever	contraindication	271751000
Smoking cessation assistance	contraindication	384742004
Angle-closure glaucoma	contraindication	392291006	DOID:13550
Chronic myocardial ischemia	contraindication	413844008	DOID:3393
Disorder of coronary artery	contraindication	414024009
Myocardial ischemia	contraindication	414795007	DOID:3393
Smokes tobacco daily	contraindication	449868002
Severe Hypoxemia	contraindication
Theophylline Toxicity	contraindication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	7.53	Basic
pKa2	3.53	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Histamine H1 receptor	GPCR	P35367	HRH1_HUMAN	ANTAGONIST	Ki	8.70		WOMBAT-PK	CHEMBL
D(2) dopamine receptor	GPCR	P14416	DRD2_HUMAN		Ki	6.42		CHEMBL
5-hydroxytryptamine receptor 2A	GPCR	P28223	5HT2A_HUMAN		Ki	7.30		CHEMBL
Cytochrome P450 2D6	Enzyme	P10635	CP2D6_HUMAN		Ki	5.41		WOMBAT-PK
Envelope glycoprotein gp160	Viral envelope protein		Q75760_9HIV1		IC50	5.20		CHEMBL
Envelope glycoprotein gp160 [Cleaved into: Surface protein gp120	Unclassified		Q6QLK5_9HIV1		IC50	5.20		CHEMBL

External reference:

ID	Source
4019782	VUID
N0000147873	NUI
D00672	KEGG_DRUG
10246-75-0	SECONDARY_CAS_RN
4017874	VANDF
4017875	VANDF
4019782	VANDF
C0020404	UMLSCUI
CHEBI:5818	CHEBI
CHEMBL1201007	ChEMBL_ID
CHEMBL896	ChEMBL_ID
CHEMBL3186993	ChEMBL_ID
CHEMBL1200467	ChEMBL_ID
DB00557	DRUGBANK_ID
D006919	MESH_DESCRIPTOR_UI
3658	PUBCHEM_CID
7199	IUPHAR_LIGAND_ID
599	INN_ID
2192-20-3	SECONDARY_CAS_RN
30S50YM8OG	UNII
154987	RXNORM
4857	MMSL
4858	MMSL
4859	MMSL
6478	MMSL
7094	MMSL
d00907	MMSL
001451	NDDF
001452	NDDF
001453	NDDF
372856003	SNOMEDCT_US
80165005	SNOMEDCT_US
83933007	SNOMEDCT_US
83945003	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Vistaril	HUMAN PRESCRIPTION DRUG LABEL	1	0069-5410	CAPSULE	25 mg	ORAL	NDA	15 sections
Vistaril	HUMAN PRESCRIPTION DRUG LABEL	1	0069-5410	CAPSULE	25 mg	ORAL	NDA	15 sections
Vistaril	HUMAN PRESCRIPTION DRUG LABEL	1	0069-5420	CAPSULE	50 mg	ORAL	NDA	15 sections
Vistaril	HUMAN PRESCRIPTION DRUG LABEL	1	0069-5420	CAPSULE	50 mg	ORAL	NDA	15 sections
Vistaril	HUMAN PRESCRIPTION DRUG LABEL	1	0069-5440	SUSPENSION	25 mg	ORAL	NDA	15 sections
Hydroxyzine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0093-5060	TABLET, FILM COATED	10 mg	ORAL	ANDA	13 sections
Hydroxyzine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0093-5060	TABLET, FILM COATED	10 mg	ORAL	ANDA	13 sections
Hydroxyzine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0093-5061	TABLET, FILM COATED	25 mg	ORAL	ANDA	13 sections
Hydroxyzine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0093-5061	TABLET, FILM COATED	25 mg	ORAL	ANDA	13 sections
Hydroxyzine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0093-5062	TABLET, FILM COATED	50 mg	ORAL	ANDA	13 sections
Hydroxyzine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0093-5062	TABLET, FILM COATED	50 mg	ORAL	ANDA	13 sections
Hydroxyzine Pamoate	HUMAN PRESCRIPTION DRUG LABEL	1	0115-1670	CAPSULE	25 mg	ORAL	ANDA	13 sections
Hydroxyzine Pamoate	HUMAN PRESCRIPTION DRUG LABEL	1	0115-1671	CAPSULE	50 mg	ORAL	ANDA	13 sections
Hydroxyzine Pamoate	HUMAN PRESCRIPTION DRUG LABEL	1	0115-1803	CAPSULE	25 mg	ORAL	ANDA	13 sections
Hydroxyzine Pamoate	HUMAN PRESCRIPTION DRUG LABEL	1	0115-1804	CAPSULE	50 mg	ORAL	ANDA	13 sections
Hydroxyzine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0121-4822	SYRUP	10 mg	ORAL	ANDA	14 sections
Hydroxyzine Pamoate	HUMAN PRESCRIPTION DRUG LABEL	1	0185-0613	CAPSULE	25 mg	ORAL	ANDA	14 sections
Hydroxyzine Pamoate	HUMAN PRESCRIPTION DRUG LABEL	1	0185-0613	CAPSULE	25 mg	ORAL	ANDA	14 sections
Hydroxyzine Pamoate	HUMAN PRESCRIPTION DRUG LABEL	1	0185-0613	CAPSULE	25 mg	ORAL	ANDA	14 sections
hydroxyzine pamoate	HUMAN PRESCRIPTION DRUG LABEL	1	0185-0615	CAPSULE	50 mg	ORAL	ANDA	14 sections
hydroxyzine pamoate	HUMAN PRESCRIPTION DRUG LABEL	1	0185-0615	CAPSULE	50 mg	ORAL	ANDA	14 sections
hydroxyzine pamoate	HUMAN PRESCRIPTION DRUG LABEL	1	0185-0615	CAPSULE	50 mg	ORAL	ANDA	14 sections
hydroxyzine pamoate	HUMAN PRESCRIPTION DRUG LABEL	1	0185-0674	CAPSULE	25 mg	ORAL	ANDA	14 sections
hydroxyzine pamoate	HUMAN PRESCRIPTION DRUG LABEL	1	0185-0674	CAPSULE	25 mg	ORAL	ANDA	14 sections
hydroxyzine pamoate	HUMAN PRESCRIPTION DRUG LABEL	1	0185-0674	CAPSULE	25 mg	ORAL	ANDA	14 sections
Hydroxyzine pamoate	HUMAN PRESCRIPTION DRUG LABEL	1	0185-0676	CAPSULE	50 mg	ORAL	ANDA	14 sections
Hydroxyzine pamoate	HUMAN PRESCRIPTION DRUG LABEL	1	0185-0676	CAPSULE	50 mg	ORAL	ANDA	14 sections
Hydroxyzine pamoate	HUMAN PRESCRIPTION DRUG LABEL	1	0185-0676	CAPSULE	50 mg	ORAL	ANDA	14 sections
Hydroxyzine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0404-9877	INJECTION, SOLUTION	50 mg	INTRAMUSCULAR	ANDA	9 sections
Hydroxyzine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0404-9877	INJECTION, SOLUTION	50 mg	INTRAMUSCULAR	ANDA	9 sections