haloperidol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
antipsychotics, haloperidol derivatives	1353	52-86-8

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: haloperidol aloperidin haloperin sigaperidol haloperidol lactate	A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279) Molecular weight: 375.87 Formula: C21H23ClFNO2 CLOGP: 3.85 LIPINSKI: 0 HAC: 3 HDO: 1 TPSA: 40.54 ALOGS: -4.93 ROTB: 6 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

haloperidol
aloperidin
haloperin
sigaperidol
haloperidol lactate

A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279)

Molecular weight: 375.87
Formula: C21H23ClFNO2
CLOGP: 3.85
LIPINSKI: 0
HAC: 3
HDO: 1
TPSA: 40.54
ALOGS: -4.93
ROTB: 6

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
8	mg	O
8	mg	P
3.30	mg	P

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	2	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	0.04 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	1 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	0.57 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	60 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution)	17 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	7.80 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.08 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	35 hours	Lombardo F, Berellini G, Obach RS

Approvals:

Date	Agency	Company	Orphan
April 12, 1967	FDA	ORTHO MCNEIL

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Neuroleptic malignant syndrome	1473.28	14.35	479	37381	10651	50556613
Extrapyramidal disorder	1260.97	14.35	432	37428	11338	50555926
Intentional self-injury	751.78	14.35	360	37500	22752	50544512
Catatonia	434.61	14.35	146	37714	3590	50563674
Akathisia	430.76	14.35	179	37681	8050	50559214
Drug interaction	413.40	14.35	619	37241	199002	50368262
Dystonia	385.21	14.35	185	37675	11741	50555523
Sopor	356.08	14.35	208	37652	19671	50547593
Muscle rigidity	340.46	14.35	160	37700	9669	50557595
Hyperprolactinaemia	289.38	14.35	105	37755	3260	50564004
Agitation	286.63	14.35	270	37590	53114	50514150
Psychotic disorder	285.76	14.35	187	37673	21625	50545639
Delusion	267.61	14.35	139	37721	10430	50556834
Hallucination, auditory	259.95	14.35	137	37723	10591	50556673
Salivary hypersecretion	252.27	14.35	115	37745	6476	50560788
Delirium	235.89	14.35	209	37651	37983	50529281
Parkinsonism	220.10	14.35	115	37745	8732	50558532
Aggression	217.30	14.35	156	37704	20960	50546304
Electrocardiogram QT prolonged	213.18	14.35	227	37633	51659	50515605
Intentional overdose	208.05	14.35	245	37615	62259	50505005
Somnolence	198.79	14.35	389	37471	154596	50412668
Tardive dyskinesia	196.60	14.35	100	37760	7179	50560085
Suicide attempt	189.35	14.35	213	37647	51519	50515745
Arthralgia	188.98	14.35	48	37812	438654	50128610
Pain	186.53	14.35	101	37759	578802	49988462
Psychomotor hyperactivity	184.34	14.35	104	37756	9197	50558067
Sedation	184.01	14.35	165	37695	30445	50536819
Hypothermia	167.13	14.35	107	37753	11909	50555355
Fatigue	165.73	14.35	172	37688	707429	49859835
Weight increased	164.63	14.35	423	37437	201468	50365796
Schizophrenia	161.07	14.35	88	37772	7309	50559955
Overdose	157.57	14.35	274	37586	99453	50467811
Coma	152.39	14.35	200	37660	56679	50510585
Restlessness	147.95	14.35	134	37726	25039	50542225
Joint swelling	144.81	14.35	10	37850	245276	50321988
Bradykinesia	142.12	14.35	66	37794	3877	50563387
Torsade de pointes	139.39	14.35	95	37765	11740	50555524
Headache	137.63	14.35	107	37753	506428	50060836
Tremor	133.56	14.35	277	37583	114626	50452638
Abnormal behaviour	128.18	14.35	111	37749	19547	50547717
Blood creatine phosphokinase increased	127.52	14.35	126	37734	26241	50541023
Rheumatoid arthritis	126.44	14.35	6	37854	202544	50364720
Alopecia	121.62	14.35	19	37841	245028	50322236
Dyskinesia	119.89	14.35	125	37735	27736	50539528
Confusional state	118.27	14.35	356	37504	185572	50381692
Rash	111.81	14.35	98	37762	437373	50129891
Hypertonia	111.43	14.35	56	37804	3917	50563347
Dysarthria	110.34	14.35	138	37722	37265	50529999
Hallucination	109.67	14.35	154	37706	46503	50520761
Sluggishness	108.71	14.35	57	37803	4356	50562908
Abdominal discomfort	106.20	14.35	22	37838	231619	50335645
Infusion related reaction	105.88	14.35	5	37855	169552	50397712
Swelling	105.71	14.35	13	37847	200859	50366405
Arthropathy	104.29	14.35	3	37857	157903	50409361
Oculogyric crisis	102.15	14.35	39	37821	1398	50565866
Depressed level of consciousness	101.24	14.35	157	37703	51796	50515468
Cogwheel rigidity	100.93	14.35	41	37819	1736	50565528
Galactorrhoea	97.20	14.35	50	37810	3673	50563591
Mutism	96.45	14.35	37	37823	1344	50565920
Tachycardia	93.82	14.35	221	37639	99542	50467722
Toxicity to various agents	92.11	14.35	358	37502	212141	50355123
Altered state of consciousness	90.16	14.35	96	37764	21814	50545450
Sinusitis	89.82	14.35	11	37849	170547	50396717
Paranoia	89.73	14.35	69	37791	10279	50556985
Pruritus	88.80	14.35	51	37809	283517	50283747
Pain in extremity	88.44	14.35	47	37813	272818	50294446
Systemic lupus erythematosus	88.26	14.35	4	37856	140618	50426646
Bradyphrenia	86.08	14.35	55	37805	6097	50561167
Nasopharyngitis	85.01	14.35	20	37840	192907	50374357
Blood prolactin increased	84.91	14.35	43	37817	3056	50564208
Embolism venous	84.02	14.35	40	37820	2485	50564779
Treatment noncompliance	80.67	14.35	106	37754	30044	50537220
Peripheral swelling	80.26	14.35	27	37833	205909	50361355
Suicidal ideation	78.20	14.35	145	37715	55240	50512024
Mania	78.04	14.35	65	37795	10851	50556413
Stupor	76.27	14.35	42	37818	3541	50563723
Torticollis	75.07	14.35	33	37827	1703	50565561
Drug abuse	75.06	14.35	149	37711	59697	50507567
Drug intolerance	73.57	14.35	36	37824	219068	50348196
Psychomotor retardation	72.58	14.35	40	37820	3378	50563886
Pneumonia aspiration	72.34	14.35	102	37758	30902	50536362
Rhabdomyolysis	69.21	14.35	113	37747	38914	50528350
Psychotic symptom	68.96	14.35	28	37832	1184	50566080
Drug level increased	68.17	14.35	78	37782	19190	50548074
Disorientation	67.39	14.35	106	37754	35378	50531886
Negativism	65.89	14.35	20	37840	350	50566914
Persecutory delusion	65.05	14.35	33	37827	2354	50564910
Encephalitis autoimmune	64.58	14.35	27	37833	1231	50566033
Contraindicated product administered	64.51	14.35	16	37844	148942	50418322
Urinary retention	63.84	14.35	88	37772	26102	50541162
Ileus paralytic	63.69	14.35	39	37821	4011	50563253
Hypersensitivity	61.40	14.35	43	37817	215118	50352146
Wound	60.41	14.35	5	37855	105789	50461475
Pleurothotonus	60.40	14.35	26	37834	1275	50565989
Nausea	60.14	14.35	298	37562	705100	49862164
Toxic epidermal necrolysis	59.59	14.35	76	37784	20916	50546348
Drooling	59.47	14.35	35	37825	3349	50563915
Hypernatraemia	58.89	14.35	44	37816	6277	50560987
Dyspnoea	57.88	14.35	213	37647	547395	50019869
Mental impairment	57.19	14.35	57	37803	11987	50555277
Stereotypy	56.86	14.35	18	37842	364	50566900
Gestational diabetes	56.60	14.35	46	37814	7419	50559845
Injection site pain	56.42	14.35	8	37852	111016	50456248
Hyponatraemia	55.37	14.35	178	37682	95961	50471303
Hyperthermia	53.30	14.35	45	37815	7651	50559613
Cardiac arrest	52.90	14.35	160	37700	83491	50483773
Discomfort	52.37	14.35	9	37851	108371	50458893
Granulocytopenia	52.31	14.35	38	37822	5193	50562071
Diarrhoea	52.18	14.35	245	37615	588231	49979033
Product dose omission issue	52.09	14.35	37	37823	183801	50383463
Treatment failure	51.96	14.35	19	37841	137618	50429646
Dysphagia	51.61	14.35	151	37709	77367	50489897
Oromandibular dystonia	50.39	14.35	17	37843	423	50566841
Lethargy	50.27	14.35	113	37747	49319	50517945
Accidental exposure to product by child	48.99	14.35	21	37839	1019	50566245
Serotonin syndrome	48.56	14.35	75	37785	24638	50542626
Miosis	48.09	14.35	39	37821	6271	50560993
Arthritis	47.11	14.35	5	37855	86716	50480548
Hyperammonaemic encephalopathy	46.91	14.35	25	37835	1974	50565290
Mental disorder	46.41	14.35	69	37791	21922	50545342
Echolalia	46.33	14.35	13	37847	170	50567094
Cognitive disorder	46.15	14.35	102	37758	44021	50523243
Unresponsive to stimuli	45.54	14.35	82	37778	30527	50536737
Back pain	45.22	14.35	59	37801	219971	50347293
Schizoaffective disorder	44.60	14.35	25	37835	2181	50565083
Bradycardia	44.32	14.35	127	37733	64299	50502965
Antipsychotic drug level increased	44	14.35	28	37832	3081	50564183
Urticaria	42.38	14.35	22	37838	129539	50437725
Cough	41.57	14.35	73	37787	241191	50326073
Disturbance in attention	40.72	14.35	79	37781	31107	50536157
Distractibility	39.90	14.35	14	37846	393	50566871
Hallucination, visual	39.33	14.35	55	37805	16527	50550737
Akinesia	38.75	14.35	20	37840	1479	50565785
Hypoxic-ischaemic encephalopathy	38.62	14.35	28	37832	3814	50563450
Contusion	38.27	14.35	18	37842	112165	50455099
Mental status changes	38.09	14.35	84	37776	36188	50531076
Impaired healing	37.97	14.35	4	37856	69782	50497482
White blood cell count increased	37.96	14.35	92	37768	42148	50525116
Hyperreflexia	37.67	14.35	31	37829	5087	50562177
Eosinophilic myocarditis	37.49	14.35	13	37847	352	50566912
Waxy flexibility	37.06	14.35	10	37850	112	50567152
Pericarditis	37	14.35	7	37853	78682	50488582
Hallucinations, mixed	36.98	14.35	28	37832	4075	50563189
Injection site erythema	36.69	14.35	6	37854	74930	50492334
Pulmonary embolism	36.61	14.35	162	37698	101542	50465722
Chest discomfort	36.36	14.35	12	37848	92710	50474554
Myalgia	35.22	14.35	25	37835	124294	50442970
Psoriasis	34.98	14.35	5	37855	68995	50498269
Metabolic syndrome	34.90	14.35	18	37842	1329	50565935
Abdominal pain upper	34.52	14.35	41	37819	159268	50407996
Paraesthesia	34.31	14.35	24	37836	120219	50447045
Herpes zoster	33.92	14.35	6	37854	70780	50496484
Somatic symptom disorder of pregnancy	33.75	14.35	9	37851	96	50567168
Negative symptoms in schizophrenia	33.26	14.35	9	37851	102	50567162
Sexually inappropriate behaviour	33.02	14.35	9	37851	105	50567159
Illogical thinking	32.87	14.35	8	37852	57	50567207
Feeling guilty	32.77	14.35	13	37847	517	50566747
Respiratory failure	32.63	14.35	145	37715	91036	50476228
Electroencephalogram abnormal	31.80	14.35	24	37836	3475	50563789
Inappropriate antidiuretic hormone secretion	31.78	14.35	44	37816	13099	50554165
Therapeutic product effect decreased	31.68	14.35	33	37827	136017	50431247
Speech disorder	31.49	14.35	77	37783	35471	50531793
Myocarditis	31.24	14.35	34	37826	7913	50559351
Sudden death	31.13	14.35	36	37824	8955	50558309
Hypersexuality	31.12	14.35	12	37848	442	50566822
Opisthotonus	31.05	14.35	11	37849	318	50566946
Nuchal rigidity	31.02	14.35	13	37847	596	50566668
Impulsive behaviour	30.78	14.35	17	37843	1441	50565823
Musculoskeletal pain	30.75	14.35	8	37852	72169	50495095
Sinus bradycardia	30.19	14.35	43	37817	13140	50554124
Behaviour disorder	30.16	14.35	20	37840	2360	50564904
Dizziness	30.12	14.35	145	37715	346224	50221040
Influenza	29.58	14.35	15	37845	89523	50477741
Social avoidant behaviour	29.53	14.35	21	37839	2776	50564488
Nephrogenic diabetes insipidus	29.44	14.35	14	37846	867	50566397
Neutrophil count increased	29.18	14.35	44	37816	14151	50553113
Chest pain	29.12	14.35	55	37805	176827	50390437
Generalised tonic-clonic seizure	28.84	14.35	62	37798	26248	50541016
Osteoarthritis	28.48	14.35	8	37852	68598	50498666
Refusal of treatment by patient	27.92	14.35	26	37834	5027	50562237
Disorganised speech	27.88	14.35	14	37846	977	50566287
Amenorrhoea	27.76	14.35	33	37827	8451	50558813
Psychomotor skills impaired	27.75	14.35	18	37842	2046	50565218
Flushing	27.48	14.35	8	37852	67007	50500257
Leukopenia	26.94	14.35	111	37749	67417	50499847
Flight of ideas	26.91	14.35	10	37850	332	50566932
Leukocytosis	26.84	14.35	55	37805	22524	50544740
Electrocardiogram PR prolongation	26.73	14.35	12	37848	651	50566613
Irritability	26.71	14.35	63	37797	28363	50538901
Screaming	26.13	14.35	20	37840	2958	50564306
False positive investigation result	26.05	14.35	11	37849	514	50566750
Asthenia	25.77	14.35	137	37723	318905	50248359
Bronchitis	25.70	14.35	24	37836	104135	50463129
Dementia	25.27	14.35	44	37816	15953	50551311
Nasal congestion	25.23	14.35	4	37856	51116	50516148
Grandiosity	24.84	14.35	9	37851	278	50566986
Stress	24.83	14.35	5	37855	53788	50513476
Thinking abnormal	24.60	14.35	33	37827	9534	50557730
Parkinsonian gait	24.42	14.35	10	37850	432	50566832
Femoral neck fracture	24.28	14.35	29	37831	7461	50559803
Stomatitis	24.25	14.35	24	37836	101320	50465944
Reduced facial expression	24.17	14.35	15	37845	1579	50565685
Infection	24.13	14.35	59	37801	172895	50394369
Dermatitis exfoliative	23.79	14.35	24	37836	5118	50562146
Intentional product misuse	23.75	14.35	83	37777	46651	50520613
Burning sensation	23.73	14.35	3	37857	45443	50521821
Dyspepsia	23.61	14.35	13	37847	74084	50493180
Haemoglobin urine	23.59	14.35	7	37853	113	50567151
Seizure	23.57	14.35	160	37700	117714	50449550
Fibromyalgia	23.41	14.35	3	37857	44975	50522289
Drug ineffective	23.32	14.35	453	37407	818880	49748384
Duodenal stenosis	23.31	14.35	10	37850	486	50566778
Influenza like illness	23.30	14.35	7	37853	57452	50509812
Hypoaesthesia	23.28	14.35	37	37823	127220	50440044
Dyspnoea exertional	23.16	14.35	5	37855	51228	50516036
Autonomic nervous system imbalance	23.11	14.35	17	37843	2368	50564896
Diabetic coma	23.03	14.35	11	37849	688	50566576
Differential white blood cell count abnormal	23.03	14.35	11	37849	688	50566576
Blunted affect	22.96	14.35	8	37852	220	50567044
Electroconvulsive therapy	22.76	14.35	6	37854	61	50567203
Staring	22.68	14.35	14	37846	1460	50565804
Muscle enzyme increased	22.62	14.35	7	37853	131	50567133
Bone marrow eosinophilic leukocyte count increased	22.58	14.35	5	37855	22	50567242
Hepatic enzyme increased	22.36	14.35	43	37817	137337	50429927
Psychiatric decompensation	22.08	14.35	13	37847	1245	50566019
Electrolyte imbalance	21.81	14.35	43	37817	17126	50550138
Agranulocytosis	21.80	14.35	49	37811	21372	50545892
Myocardial reperfusion injury	21.73	14.35	5	37855	27	50567237
Incorrect route of product administration	21.63	14.35	45	37815	18621	50548643
Allergic hepatitis	21.58	14.35	5	37855	28	50567236
Asthma	21.55	14.35	21	37839	89316	50477948
Self-medication	21.41	14.35	16	37844	2283	50564981
Tongue biting	21.41	14.35	13	37847	1317	50565947
Weight decreased	21.38	14.35	89	37771	221156	50346108
Refusal of examination	21.35	14.35	6	37854	79	50567185
Polydipsia	21.09	14.35	18	37842	3106	50564158
Antipsychotic drug level below therapeutic	21.00	14.35	8	37852	285	50566979
Apallic syndrome	20.98	14.35	10	37850	623	50566641
Lactate pyruvate ratio increased	20.62	14.35	6	37854	90	50567174
Exposure during pregnancy	20.58	14.35	158	37702	120857	50446407
Injection site reaction	20.46	14.35	6	37854	50026	50517238
Protrusion tongue	20.31	14.35	8	37852	312	50566952
Respiratory depression	20.24	14.35	34	37826	11976	50555288
COVID-19	20.21	14.35	5	37855	46657	50520607
Delusion of reference	20.09	14.35	6	37854	99	50567165
Urinary incontinence	19.77	14.35	56	37804	28152	50539112
Acute psychosis	19.67	14.35	15	37845	2205	50565059
Venous thrombosis limb	19.55	14.35	16	37844	2606	50564658
Lipids decreased	19.52	14.35	4	37856	11	50567253
Folliculitis	19.51	14.35	3	37857	39222	50528042
Hyperthermia malignant	19.51	14.35	10	37850	729	50566535
Communication disorder	19.43	14.35	15	37845	2246	50565018
Muscle strength abnormal	19.42	14.35	5	37855	46	50567218
Pressure of speech	19.12	14.35	9	37851	545	50566719
Rash pruritic	19.09	14.35	6	37854	47840	50519424
Diabetes mellitus	19.08	14.35	80	37780	48953	50518311
Euphoric mood	18.90	14.35	19	37841	4036	50563228
Pulmonary vasculitis	18.61	14.35	5	37855	55	50567209
Clonus	18.43	14.35	19	37841	4156	50563108
Blood citric acid increased	18.29	14.35	5	37855	59	50567205
Ill-defined disorder	18.28	14.35	9	37851	54645	50512619
Hepatitis acute	18.28	14.35	26	37834	7935	50559329
Brain oedema	18.22	14.35	33	37827	12337	50554927
Brief psychotic disorder with marked stressors	18.21	14.35	5	37855	60	50567204
Myoclonus	18.09	14.35	36	37824	14434	50552830
Coma scale abnormal	18.04	14.35	20	37840	4751	50562513
Cardio-respiratory arrest	18	14.35	84	37776	53808	50513456
Dry skin	17.99	14.35	5	37855	43186	50524078
Epileptic encephalopathy	17.87	14.35	7	37853	269	50566995
Multiple sclerosis relapse	17.85	14.35	5	37855	42959	50524305
Apathy	17.85	14.35	25	37835	7523	50559741
Cardiomyopathy alcoholic	17.81	14.35	4	37856	19	50567245
Carnitine deficiency	17.61	14.35	6	37854	154	50567110
Hypomania	17.23	14.35	19	37841	4486	50562778
Vulvovaginal candidiasis	17.14	14.35	15	37845	2677	50564587
Lower respiratory tract infection	17.11	14.35	28	37832	95173	50472091
Illusion	17.07	14.35	10	37850	949	50566315
Neutropenia	16.83	14.35	177	37683	147788	50419476
Poor personal hygiene	16.76	14.35	7	37853	318	50566946
Inflammation	16.70	14.35	11	37849	56901	50510363
Anticonvulsant drug level above therapeutic	16.68	14.35	8	37852	505	50566759
Red blood cells urine	16.68	14.35	8	37852	505	50566759
Ureteric obstruction	16.67	14.35	12	37848	1616	50565648
Granulomatous liver disease	16.62	14.35	9	37851	734	50566530
Blood pressure increased	16.60	14.35	48	37812	133084	50434180
Mydriasis	16.48	14.35	29	37831	10598	50556666
Intentional product use issue	16.43	14.35	20	37840	76898	50490366
Encephalopathy	16.38	14.35	59	37801	33652	50533612
Blood glucose	16.26	14.35	4	37856	30	50567234
Electrocardiogram abnormal	16.24	14.35	24	37836	7581	50559683
Somatic hallucination	16.06	14.35	3	37857	4	50567260
Hypokinesia	16.01	14.35	31	37829	12186	50555078
Fluid retention	15.97	14.35	9	37851	50640	50516624
Night sweats	15.75	14.35	3	37857	33571	50533693
Retinitis pigmentosa	15.71	14.35	5	37855	103	50567161
Wheezing	15.65	14.35	14	37846	62033	50505231
Poisoning	15.63	14.35	31	37829	12398	50554866
Aspiration	15.31	14.35	26	37834	9238	50558026
Malaise	15.25	14.35	169	37691	335363	50231901
Circadian rhythm sleep disorder	15.23	14.35	6	37854	234	50567030
Systemic infection	15.10	14.35	13	37847	2270	50564994
Grimacing	15.02	14.35	7	37853	414	50566850
Hyperthyroidism	14.87	14.35	30	37830	12145	50555119
Brain death	14.76	14.35	14	37846	2769	50564495
Antidepressant drug level increased	14.75	14.35	6	37854	255	50567009
Tonic clonic movements	14.73	14.35	10	37850	1227	50566037
Erythema	14.70	14.35	58	37802	146356	50420908
Mental disorder due to a general medical condition	14.69	14.35	5	37855	128	50567136
Tachyphrenia	14.67	14.35	10	37850	1235	50566029
Malignant catatonia	14.61	14.35	5	37855	130	50567134
Tachycardia paroxysmal	14.53	14.35	6	37854	265	50566999
Cellulitis	14.50	14.35	19	37841	70779	50496485
Eosinophil count abnormal	14.45	14.35	7	37853	452	50566812
Trismus	14.36	14.35	15	37845	3333	50563931

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Neuroleptic malignant syndrome	1804.85	13.05	753	47408	15395	29510971
Extrapyramidal disorder	1629.88	13.05	626	47535	10205	29516161
Dystonia	679.11	13.05	327	47834	9422	29516944
Intentional self-injury	559.06	13.05	311	47850	12150	29514216
Akathisia	508.75	13.05	239	47922	6503	29519863
Muscle rigidity	408.77	13.05	230	47931	9181	29517185
Agitation	372.54	13.05	438	47723	50866	29475500
Parkinsonism	324.56	13.05	181	47980	7097	29519269
Sedation	320.94	13.05	249	47912	17156	29509210
Catatonia	320.51	13.05	153	48008	4315	29522051
Weight increased	315.89	13.05	497	47664	76170	29450196
Psychotic disorder	309.22	13.05	260	47901	20094	29506272
Tardive dyskinesia	305.57	13.05	156	48005	5102	29521264
Delirium	291.94	13.05	340	47821	39057	29487309
Salivary hypersecretion	263.28	13.05	159	48002	7250	29519116
Aggression	252.13	13.05	300	47861	35241	29491125
Blood creatine phosphokinase increased	244.83	13.05	316	47845	40328	29486038
Hyperprolactinaemia	244.21	13.05	88	48073	1182	29525184
Suicide attempt	240.43	13.05	287	47874	33823	29492543
Sopor	238.42	13.05	173	47988	10761	29515605
Delusion	203.54	13.05	159	48002	11057	29515309
Tachycardia	197.60	13.05	392	47769	72018	29454348
Electrocardiogram QT prolonged	197.60	13.05	268	47893	35869	29490497
Somnolence	192.65	13.05	453	47708	93502	29432864
Hallucination, auditory	191.64	13.05	144	48017	9449	29516917
Drug interaction	187.02	13.05	724	47437	196661	29329705
Schizophrenia	180.99	13.05	120	48041	6445	29519921
Dyskinesia	173.93	13.05	188	47973	19873	29506493
Antipsychotic drug level below therapeutic	158.23	13.05	73	48088	1901	29524465
Intentional overdose	150.47	13.05	244	47917	38284	29488082
Hypertonia	145.98	13.05	86	48075	3743	29522623
Disinhibition	144.67	13.05	75	48086	2532	29523834
Emotional poverty	139.21	13.05	45	48116	424	29525942
Diarrhoea	137.77	13.05	206	47955	332492	29193874
Rhabdomyolysis	137.58	13.05	305	47856	60503	29465863
Restlessness	134.53	13.05	173	47988	21972	29504394
Tremor	134.01	13.05	339	47822	73199	29453167
Obsessive-compulsive disorder	131.86	13.05	86	48075	4490	29521876
Fatigue	129.36	13.05	198	47963	316623	29209743
Arthralgia	125.39	13.05	36	48125	139581	29386785
Rash	116.20	13.05	84	48077	189735	29336631
Dyspnoea	116.15	13.05	223	47938	326509	29199857
Therapeutic product effect variable	115.79	13.05	58	48103	1819	29524547
Serotonin syndrome	105.09	13.05	136	48025	17376	29508990
Embolism venous	104.77	13.05	49	48112	1317	29525049
Granulocytopenia	104.47	13.05	83	48078	5911	29520455
Hypothermia	102.64	13.05	99	48062	9140	29517226
Oculogyric crisis	101.86	13.05	48	48113	1313	29525053
Coma	100.83	13.05	208	47953	39242	29487124
Toxicity to various agents	100.74	13.05	552	47609	173109	29353257
Cogwheel rigidity	99.72	13.05	46	48115	1197	29525169
Nausea	97.92	13.05	203	47958	289052	29237314
Euphoric mood	97.62	13.05	73	48088	4752	29521614
Psychomotor hyperactivity	95.02	13.05	90	48071	8123	29518243
Oropharyngeal spasm	93.63	13.05	26	48135	136	29526230
Dizziness	93.21	13.05	103	48058	189581	29336785
Increased appetite	93.13	13.05	78	48083	5986	29520380
Sluggishness	92.70	13.05	59	48102	2952	29523414
Abnormal behaviour	89.61	13.05	146	48015	22981	29503385
Headache	86.02	13.05	94	48067	173913	29352453
Altered state of consciousness	84.55	13.05	131	48030	19758	29506608
Incorrect route of product administration	82.88	13.05	95	48066	10706	29515660
Hyperthermia	82.80	13.05	89	48072	9341	29517025
Treatment noncompliance	80.71	13.05	143	48018	24084	29502282
Pneumonia aspiration	79.36	13.05	181	47980	36556	29489810
Mutism	78.45	13.05	33	48128	684	29525682
Torsade de pointes	77.07	13.05	73	48088	6588	29519778
Dysphagia	76.88	13.05	230	47931	54696	29471670
Drooling	75.56	13.05	52	48109	2969	29523397
Pain in extremity	75.51	13.05	43	48118	110390	29415976
Asthenia	75.35	13.05	148	48013	215102	29311264
Cough	74.98	13.05	58	48103	126669	29399697
Anaemia	73.10	13.05	135	48026	200816	29325550
Cognitive disorder	72.30	13.05	134	48027	23365	29503001
Malignant catatonia	71.99	13.05	23	48138	208	29526158
Confusional state	71.71	13.05	403	47758	127474	29398892
Pain	70.84	13.05	106	48055	171326	29355040
Cardiac failure congestive	68.22	13.05	20	48141	76561	29449805
Depressed level of consciousness	66.88	13.05	170	47991	36772	29489594
Dysarthria	66.43	13.05	152	48009	30759	29495607
Myocardial infarction	64.58	13.05	51	48110	110245	29416121
Psychotic symptom	62.56	13.05	35	48126	1379	29524987
Hallucination	62.33	13.05	187	47974	44525	29481841
Torticollis	62.19	13.05	32	48129	1063	29525303
Myoclonus	61.29	13.05	91	48070	13218	29513148
Spasmodic dysphonia	60.14	13.05	16	48145	69	29526297
Nasopharyngitis	60.14	13.05	12	48149	59653	29466713
Paranoia	59.70	13.05	77	48084	9800	29516566
Protrusion tongue	59.55	13.05	19	48142	171	29526195
Back pain	58.99	13.05	48	48113	102236	29424130
Antipsychotic drug level increased	58.87	13.05	46	48115	3197	29523169
Persecutory delusion	58.67	13.05	39	48122	2102	29524264
Febrile neutropenia	58.37	13.05	58	48103	112182	29414184
Overdose	57.56	13.05	270	47891	79549	29446817
Opisthotonus	56.81	13.05	23	48138	431	29525935
Disorientation	56.76	13.05	139	48022	29376	29496990
Infusion related reaction	55.98	13.05	4	48157	43882	29482484
Death	55.35	13.05	329	47832	341755	29184611
Myocarditis	54.94	13.05	78	48083	10878	29515488
Bradykinesia	54.30	13.05	45	48116	3402	29522964
Schizoaffective disorder	53.74	13.05	29	48132	1063	29525303
Pruritus	53.51	13.05	67	48094	116782	29409584
Product dose omission issue	53.41	13.05	47	48114	96336	29430030
Stupor	52.16	13.05	40	48121	2704	29523662
Intestinal pseudo-obstruction	51.92	13.05	30	48131	1258	29525108
Social avoidant behaviour	51.83	13.05	41	48120	2901	29523465
Mania	51.52	13.05	67	48094	8596	29517770
Neuropathy peripheral	50.94	13.05	26	48135	71001	29455365
Speech disorder	49.81	13.05	115	48046	23401	29502965
Dyslipidaemia	49.37	13.05	55	48106	6006	29520360
Ileus paralytic	48.87	13.05	51	48110	5172	29521194
Mental impairment	48.70	13.05	67	48094	9074	29517292
White blood cell count increased	48.64	13.05	153	48008	37363	29489003
Accidental exposure to product by child	47.93	13.05	29	48132	1325	29525041
Hyperreflexia	47.48	13.05	38	48123	2734	29523632
Pneumonia	46.59	13.05	318	47843	319854	29206512
Prescribed overdose	45.30	13.05	63	48098	8620	29517746
Visceral congestion	44.54	13.05	20	48141	488	29525878
Psychosexual disorder	43.72	13.05	13	48148	90	29526276
Peripheral swelling	43.27	13.05	25	48136	63714	29462652
Interstitial lung disease	43.10	13.05	20	48141	57698	29468668
Leukopenia	42.94	13.05	191	47970	55012	29471354
Blood prolactin abnormal	42.78	13.05	23	48138	837	29525529
Oromandibular dystonia	42.72	13.05	19	48142	453	29525913
Joint swelling	42.32	13.05	14	48147	49616	29476750
Priapism	42.31	13.05	44	48117	4444	29521922
Water intoxication	42.01	13.05	18	48143	391	29525975
Delusion of grandeur	41.27	13.05	18	48143	409	29525957
Encephalitis toxic	41.00	13.05	16	48145	271	29526095
Choking	40.50	13.05	43	48118	4448	29521918
Cerebrovascular accident	39.67	13.05	40	48121	76871	29449495
Urticaria	39.20	13.05	20	48141	54640	29471726
Disturbance in attention	39.19	13.05	99	48062	21325	29505041
Psychomotor retardation	39.06	13.05	35	48126	2941	29523425
Atrial fibrillation	38.31	13.05	71	48090	105575	29420791
Erythema	38.22	13.05	40	48121	75566	29450800
Psoriasis	38.21	13.05	4	48157	32223	29494143
Eye movement disorder	38.05	13.05	38	48123	3658	29522708
Chest discomfort	37.44	13.05	14	48147	45969	29480397
Blood prolactin increased	37.41	13.05	26	48135	1508	29524858
Bradyphrenia	37.39	13.05	40	48121	4174	29522192
Autonomic nervous system imbalance	37.39	13.05	31	48130	2345	29524021
Self-injurious ideation	37.15	13.05	26	48135	1525	29524841
Peptostreptococcus infection	36.62	13.05	9	48152	26	29526340
Abdominal pain upper	35.92	13.05	28	48133	60965	29465401
Refusal of treatment by patient	35.52	13.05	41	48120	4653	29521713
Pyramidal tract syndrome	35.38	13.05	13	48148	185	29526181
Trismus	35.35	13.05	30	48131	2343	29524023
Mental disorder	35.27	13.05	70	48091	12835	29513531
Obesity	35.16	13.05	60	48101	9803	29516563
Sinusitis	34.41	13.05	7	48154	34343	29492023
Waxy flexibility	34.28	13.05	11	48150	101	29526265
Epistaxis	34.08	13.05	21	48140	51683	29474683
Product packaging issue	34.02	13.05	17	48144	530	29525836
Huntington's disease	33.98	13.05	9	48152	38	29526328
Chest pain	33.34	13.05	84	48077	111889	29414477
Oral discharge	32.59	13.05	11	48150	120	29526246
Herpes zoster	32.55	13.05	5	48156	30047	29496319
Sinus tachycardia	32.25	13.05	74	48087	14995	29511371
Influenza	32.06	13.05	14	48147	41867	29484499
Coronary artery disease	31.94	13.05	16	48145	44174	29482192
Medication error	31.73	13.05	91	48070	21120	29505246
Asthma	31.70	13.05	8	48153	33841	29492525
Decreased appetite	31.38	13.05	126	48035	145216	29381150
Sudden death	30.98	13.05	70	48091	14040	29512326
Body temperature increased	30.91	13.05	71	48090	14394	29511972
Arthritis	29.93	13.05	3	48158	25016	29501350
Intentional product use issue	29.80	13.05	16	48145	42482	29483884
Injection site pain	29.76	13.05	8	48153	32438	29493928
Hypoaesthesia	29.68	13.05	26	48135	53441	29472925
Compulsive sexual behaviour	29.58	13.05	12	48149	226	29526140
Epilepsy	29.45	13.05	81	48080	18351	29508015
Angina pectoris	29.34	13.05	5	48156	27845	29498521
Withdrawal syndrome	29.29	13.05	59	48102	10933	29515433
Urinary retention	29.18	13.05	116	48045	31782	29494584
Tic	28.99	13.05	24	48137	1811	29524555
Tachypnoea	28.85	13.05	71	48090	15044	29511322
Haemorrhage	28.75	13.05	19	48142	45053	29481313
Psychiatric decompensation	28.75	13.05	22	48139	1482	29524884
Anticholinergic syndrome	28.73	13.05	18	48143	876	29525490
Colitis ischaemic	28.52	13.05	41	48120	5782	29520584
Rapid eye movement sleep behaviour disorder	28.47	13.05	10	48151	124	29526242
Gastrointestinal haemorrhage	28.34	13.05	54	48107	79479	29446887
Patient restraint	27.73	13.05	9	48152	86	29526280
Bruxism	27.70	13.05	22	48139	1565	29524801
Posturing	27.10	13.05	14	48147	469	29525897
Resting tremor	26.56	13.05	15	48146	602	29525764
HIV peripheral neuropathy	26.54	13.05	7	48154	29	29526337
Blunted affect	26.45	13.05	12	48149	300	29526066
Leukocytosis	26.28	13.05	85	48076	21057	29505309
Oedema peripheral	26.17	13.05	84	48077	103473	29422893
Abdominal discomfort	25.75	13.05	24	48137	47879	29478487
Coma scale abnormal	25.75	13.05	30	48131	3439	29522927
Paraesthesia	25.54	13.05	30	48131	53815	29472551
Acute myocardial infarction	25.18	13.05	25	48136	48413	29477953
Mental status changes	25.03	13.05	118	48043	34809	29491557
Musculoskeletal pain	24.97	13.05	8	48153	28945	29497421
Rebound effect	24.92	13.05	23	48138	2008	29524358
Cytomegalovirus infection	24.83	13.05	4	48157	23211	29503155
Irritability	24.82	13.05	86	48075	22066	29504300
Generalised tonic-clonic seizure	24.74	13.05	78	48083	19061	29507305
Reduced facial expression	24.68	13.05	15	48146	691	29525675
Stomatitis	24.56	13.05	15	48146	37098	29489268
Exhibitionism	24.54	13.05	7	48154	41	29526325
Weight decreased	24.35	13.05	145	48016	150760	29375606
Acute kidney injury	24.28	13.05	296	47865	264971	29261395
Muscle contractions involuntary	24.04	13.05	21	48140	1706	29524660
Aspiration	24.04	13.05	52	48109	10128	29516238
Foetal alcohol syndrome	24.00	13.05	9	48152	136	29526230
Completed suicide	23.79	13.05	238	47923	90008	29436358
Galactorrhoea	23.79	13.05	12	48149	382	29525984
Agranulocytosis	23.69	13.05	80	48081	20260	29506106
Diet refusal	23.57	13.05	11	48150	294	29526072
Leukaemia	23.49	13.05	30	48131	3780	29522586
Intentional product misuse	23.32	13.05	115	48046	34546	29491820
Haematochezia	23.04	13.05	16	48145	36967	29489399
Antipsychotic drug level above therapeutic	23.03	13.05	17	48144	1084	29525282
Postoperative respiratory failure	23.01	13.05	8	48153	96	29526270
Sexual dysfunction	22.91	13.05	37	48124	5777	29520589
Drug level increased	22.87	13.05	75	48086	18712	29507654
Neutrophil count increased	22.78	13.05	64	48097	14678	29511688
Pancytopenia	22.77	13.05	65	48096	83103	29443263
Thrombosis	22.63	13.05	22	48139	43023	29483343
Ascites	22.60	13.05	16	48145	36603	29489763
Apathy	22.60	13.05	38	48123	6133	29520233
Suicidal ideation	22.52	13.05	114	48047	34602	29491764
Chorea	22.47	13.05	16	48145	965	29525401
Muscle contracture	22.34	13.05	17	48144	1136	29525230
Vascular stenosis	22.02	13.05	9	48152	173	29526193
Dextrocardia	21.83	13.05	8	48153	113	29526253
Disease progression	21.71	13.05	65	48096	81851	29444515
Hyponatraemia	21.66	13.05	186	47975	67447	29458919
Hyperkalaemia	21.59	13.05	42	48119	61350	29465016
Drug withdrawal syndrome neonatal	21.35	13.05	27	48134	3368	29522998
Cardiac arrest	21.26	13.05	223	47938	85368	29440998
Urinary incontinence	21.15	13.05	67	48094	16414	29509952
Unresponsive to stimuli	21.10	13.05	89	48072	25037	29501329
Accidental exposure to product	21.04	13.05	51	48110	10702	29515664
Physical assault	21.04	13.05	16	48145	1068	29525298
Type 2 diabetes mellitus	21.02	13.05	59	48102	13522	29512844
Snoring	20.53	13.05	24	48137	2760	29523606
Skin lesion	20.32	13.05	3	48158	18569	29507797
Thinking abnormal	20.19	13.05	33	48128	5203	29521163
Colitis	20.16	13.05	13	48148	31235	29495131
Inappropriate affect	20.14	13.05	12	48149	533	29525833
Affective disorder	19.88	13.05	25	48136	3101	29523265
Drop attacks	19.86	13.05	12	48149	547	29525819
Sexual abuse	19.85	13.05	8	48153	148	29526218
Unevaluable event	19.84	13.05	12	48149	29839	29496527
Hallucinations, mixed	19.68	13.05	22	48139	2411	29523955
Fluid retention	19.47	13.05	7	48154	23553	29502813
Myalgia	19.43	13.05	59	48102	73960	29452406
Flight of ideas	19.22	13.05	10	48151	340	29526026
Parkinsonian gait	19.13	13.05	11	48150	457	29525909
Antidepressant drug level increased	19.09	13.05	7	48154	99	29526267
Pneumonitis	19.02	13.05	11	48150	28033	29498333
Cross sensitivity reaction	18.89	13.05	16	48145	1246	29525120
Hyperhidrosis	18.87	13.05	174	47987	64366	29462000
Cardio-respiratory arrest	18.82	13.05	144	48017	50457	29475909
Haemoglobin decreased	18.62	13.05	102	48059	108273	29418093
Perseveration	18.60	13.05	7	48154	107	29526259
Nasal congestion	18.59	13.05	4	48157	18875	29507491
Renal impairment	18.50	13.05	69	48092	81264	29445102
Gaze palsy	18.49	13.05	16	48145	1283	29525083
Tension	18.47	13.05	19	48142	1894	29524472
Echolalia	18.39	13.05	9	48152	268	29526098
Musculoskeletal stiffness	18.32	13.05	114	48047	37344	29489022
Multiple organ dysfunction syndrome	18.27	13.05	48	48113	63068	29463298
Hypersexuality	17.90	13.05	16	48145	1340	29525026
Dyspnoea exertional	17.66	13.05	20	48141	36470	29489896
Floppy iris syndrome	17.52	13.05	9	48152	298	29526068
Seizure	17.51	13.05	230	47931	92893	29433473
Antisocial behaviour	17.46	13.05	9	48152	300	29526066
Inappropriate antidiuretic hormone secretion	17.42	13.05	48	48113	10884	29515482
Wrong patient received product	17.38	13.05	20	48141	2262	29524104
Malignant neoplasm progression	17.23	13.05	62	48099	73797	29452569
Myelodysplastic syndrome	17.06	13.05	4	48157	17790	29508576
Labile blood pressure	16.86	13.05	11	48150	574	29525792
Judgement impaired	16.75	13.05	11	48150	581	29525785
Dysgeusia	16.70	13.05	8	48153	22666	29503700
Schizoaffective disorder bipolar type	16.65	13.05	5	48156	36	29526330
Syncope	16.63	13.05	72	48089	81299	29445067
Mumps	16.62	13.05	6	48155	81	29526285
Mydriasis	16.62	13.05	33	48128	6052	29520314
Posture abnormal	16.43	13.05	18	48143	1929	29524437
Blood pressure fluctuation	16.29	13.05	6	48155	19888	29506478
Hypersensitivity	16.27	13.05	39	48122	52864	29473502
Primary familial brain calcification	16.27	13.05	3	48158	0	29526366
Speech sound disorder	16.26	13.05	7	48154	154	29526212
Malaise	16.16	13.05	174	47987	159428	29366938
Electrocardiogram J wave	16.16	13.05	4	48157	12	29526354
Hypokinesia	16.05	13.05	37	48124	7517	29518849
Gastrointestinal disorder	15.88	13.05	14	48147	28692	29497674
Negativism	15.83	13.05	9	48152	366	29526000
Hyperammonaemia	15.81	13.05	31	48130	5632	29520734
Haematuria	15.68	13.05	30	48131	44109	29482257
Foetal arrhythmia	15.58	13.05	6	48155	98	29526268
Gender dysphoria	15.57	13.05	5	48156	46	29526320
Cyanosis	15.57	13.05	47	48114	11220	29515146
Cerebrovascular stenosis	15.46	13.05	6	48155	100	29526266
Delusional disorder, unspecified type	15.41	13.05	11	48150	666	29525700
Dysphoria	15.37	13.05	18	48143	2074	29524292
Anxiety	15.29	13.05	209	47952	85156	29441210
Hyperventilation	15.20	13.05	19	48142	2343	29524023
Hallucination, olfactory	15.11	13.05	7	48154	184	29526182
Night sweats	15.04	13.05	3	48158	14929	29511437
Visual acuity reduced	14.96	13.05	3	48158	14873	29511493
Tongue disorder	14.96	13.05	27	48134	4609	29521757
Swollen tongue	14.95	13.05	49	48112	12217	29514149
Acute psychosis	14.94	13.05	16	48145	1671	29524695
Differential white blood cell count abnormal	14.85	13.05	14	48147	1255	29525111
Rabbit syndrome	14.72	13.05	4	48157	19	29526347
Cholelithiasis	14.68	13.05	6	48155	18666	29507700
Dry skin	14.63	13.05	10	48151	23297	29503069
Dementia	14.60	13.05	47	48114	11611	29514755
Condition aggravated	14.56	13.05	326	47835	145969	29380397
Full blood count decreased	14.55	13.05	4	48157	15988	29510378
Gastrooesophageal reflux disease	14.45	13.05	18	48143	31478	29494888
Nephrolithiasis	14.45	13.05	12	48149	25322	29501044
Adactyly	14.23	13.05	5	48156	62	29526304
Exposure to extreme temperature	14.19	13.05	3	48158	3	29526363
Syndactyly	14.08	13.05	11	48150	764	29525602
Blood pressure increased	14.06	13.05	67	48094	73736	29452630
Bronchitis	14.05	13.05	24	48137	36844	29489522
Diabetic coma	14.02	13.05	11	48150	769	29525597
Gout	14.01	13.05	5	48156	16906	29509460
Abdominal distension	13.99	13.05	34	48127	45877	29480489
Impaired self-care	13.95	13.05	12	48149	955	29525411
Osteoarthritis	13.93	13.05	6	48155	18097	29508269
Flushing	13.91	13.05	16	48145	28976	29497390
Cardiomyopathy	13.70	13.05	54	48107	14733	29511633
Coprolalia	13.67	13.05	4	48157	26	29526340
Blood triglycerides increased	13.66	13.05	49	48112	12785	29513581
Polydipsia	13.58	13.05	22	48139	3443	29522923
Mucosal inflammation	13.53	13.05	19	48142	31576	29494790
Haemoptysis	13.46	13.05	18	48143	30532	29495834
Localised infection	13.46	13.05	3	48158	13813	29512553
Incoherent	13.42	13.05	24	48137	4068	29522298
Neuroleptic-induced deficit syndrome	13.42	13.05	4	48157	28	29526338
Pleural effusion	13.28	13.05	66	48095	71842	29454524
Fungal infection	13.27	13.05	3	48158	13682	29512684
Paraphilia	13.25	13.05	5	48156	77	29526289
Pleurothotonus	13.21	13.05	12	48149	1026	29525340
Impaired healing	13.09	13.05	3	48158	13555	29512811
Rebound psychosis	13.08	13.05	6	48155	154	29526212
Pulmonary hypertension	13.05	13.05	7	48154	18601	29507765

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Neuroleptic malignant syndrome	3097.58	13.42	1138	72224	23858	64401512
Extrapyramidal disorder	2720.58	13.42	970	72392	18582	64406788
Intentional self-injury	1286.51	13.42	638	72724	28406	64396964
Dystonia	936.05	13.42	448	72914	18417	64406953
Catatonia	719.68	13.42	285	73077	7335	64418035
Akathisia	713.37	13.42	319	73043	11191	64414179
Muscle rigidity	712.19	13.42	363	72999	17110	64408260
Agitation	628.77	13.42	630	72732	87737	64337633
Drug interaction	550.02	13.42	1246	72116	360837	64064533
Sopor	529.14	13.42	361	73001	29300	64396070
Parkinsonism	501.15	13.42	269	73093	14104	64411266
Psychotic disorder	494.95	13.42	368	72994	34210	64391160
Delirium	485.94	13.42	490	72872	68704	64356666
Hyperprolactinaemia	472.99	13.42	177	73185	3888	64421482
Salivary hypersecretion	457.09	13.42	239	73123	11874	64413496
Sedation	431.82	13.42	366	72996	41096	64384274
Delusion	429.13	13.42	263	73099	17751	64407619
Tardive dyskinesia	419.06	13.42	206	73156	8972	64416398
Aggression	416.95	13.42	376	72986	45856	64379514
Weight increased	403.95	13.42	804	72558	212544	64212826
Hallucination, auditory	359.90	13.42	230	73132	16709	64408661
Somnolence	351.75	13.42	739	72623	202906	64222464
Blood creatine phosphokinase increased	333.40	13.42	371	72991	58187	64367183
Electrocardiogram QT prolonged	321.03	13.42	423	72939	79025	64346345
Arthralgia	308.40	13.42	64	73298	442196	63983174
Intentional overdose	304.97	13.42	440	72922	89504	64335866
Suicide attempt	283.67	13.42	376	72986	70631	64354739
Psychomotor hyperactivity	279.49	13.42	185	73177	14266	64411104
Schizophrenia	270.94	13.42	165	73197	11003	64414367
Dyskinesia	267.35	13.42	274	73088	39114	64386256
Tremor	247.68	13.42	531	72831	147699	64277671
Fatigue	247.07	13.42	294	73068	748436	63676934
Tachycardia	246.69	13.42	533	72829	149046	64276324
Pain	239.77	13.42	169	73193	553342	63872028
Hypertonia	239.17	13.42	125	73237	6200	64419170
Rhabdomyolysis	238.46	13.42	397	72965	91329	64334041
Restlessness	234.92	13.42	257	73105	39528	64385842
Hypothermia	224.73	13.42	184	73178	19672	64405698
Headache	223.62	13.42	166	73196	529301	63896069
Sluggishness	205.71	13.42	109	73253	5561	64419809
Coma	201.21	13.42	359	73003	87256	64338114
Abnormal behaviour	189.53	13.42	212	73150	33410	64391960
Rash	188.10	13.42	148	73214	458401	63966969
Embolism venous	185.20	13.42	87	73275	3420	64421950
Cogwheel rigidity	182.89	13.42	81	73281	2772	64422598
Oculogyric crisis	178.77	13.42	77	73285	2461	64422909
Joint swelling	172.73	13.42	21	73341	215361	64210009
Bradykinesia	169.66	13.42	101	73261	6459	64418911
Confusional state	168.11	13.42	664	72698	260480	64164890
Pain in extremity	166.88	13.42	68	73294	303017	64122353
Hallucination	166.78	13.42	298	73064	72490	64352880
Rheumatoid arthritis	163.99	13.42	5	73357	164289	64261081
Nausea	162.75	13.42	414	72948	785386	63639984
Granulocytopenia	160.33	13.42	116	73246	10324	64415046
Torsade de pointes	159.96	13.42	143	73219	17220	64408150
Altered state of consciousness	159.50	13.42	206	73156	37696	64387674
Mutism	157.50	13.42	66	73296	1968	64423402
Toxicity to various agents	156.08	13.42	820	72542	362693	64062677
Dyspnoea	155.52	13.42	370	72992	718304	63707066
Infusion related reaction	154.07	13.42	8	73354	164459	64260911
Diarrhoea	150.94	13.42	379	72983	722325	63703045
Dysarthria	150.15	13.42	254	73108	59152	64366218
Pneumonia aspiration	143.98	13.42	249	73113	59022	64366348
Depressed level of consciousness	141.96	13.42	297	73065	81139	64344231
Torticollis	140.17	13.42	62	73300	2115	64423255
Nasopharyngitis	139.27	13.42	27	73335	196046	64229324
Overdose	136.97	13.42	446	72916	159120	64266250
Serotonin syndrome	135.69	13.42	194	73168	39088	64386282
Pruritus	135.47	13.42	95	73267	312305	64113065
Dysphagia	134.83	13.42	343	73019	106469	64318901
Hyperthermia	133.30	13.42	123	73239	15427	64409943
Paranoia	129.92	13.42	124	73238	16228	64409142
Alopecia	128.38	13.42	18	73344	165672	64259698
Peripheral swelling	125.07	13.42	41	73321	209112	64216258
Emotional poverty	124.84	13.42	42	73320	667	64424703
Treatment noncompliance	122.12	13.42	195	73167	43287	64382083
Drooling	117.38	13.42	74	73288	5245	64420125
Psychotic symptom	115.87	13.42	54	73308	2084	64423286
Cough	113.37	13.42	106	73256	302042	64123328
Persecutory delusion	112.72	13.42	66	73296	4092	64421278
Sinusitis	112.71	13.42	16	73346	145912	64279458
Cognitive disorder	109.22	13.42	212	73150	54875	64370495
Mania	108.12	13.42	112	73250	16174	64409196
Psychomotor retardation	107.15	13.42	69	73293	5074	64420296
Stupor	106.48	13.42	73	73289	5962	64419408
Disorientation	104.82	13.42	210	73152	55618	64369752
Dizziness	104.76	13.42	207	73155	429956	63995414
Ileus paralytic	103.74	13.42	82	73280	8333	64417037
Abdominal discomfort	100.11	13.42	41	73321	182281	64243089
Schizoaffective disorder	98.34	13.42	44	73318	1543	64423827
Malignant catatonia	97.87	13.42	30	73332	347	64425023
Galactorrhoea	97.70	13.42	55	73307	3164	64422206
Back pain	97.12	13.42	85	73277	250086	64175284
Swelling	96.48	13.42	31	73331	160187	64265183
Bradyphrenia	93.70	13.42	81	73281	9325	64416045
Accidental exposure to product by child	93.63	13.42	49	73313	2436	64422934
Suicidal ideation	92.72	13.42	222	73140	66320	64359050
Arthropathy	91.70	13.42	14	73348	120953	64304417
Social avoidant behaviour	87.27	13.42	58	73304	4499	64420871
Injection site pain	86.52	13.42	12	73350	111396	64313974
Oropharyngeal spasm	86.04	13.42	25	73337	237	64425133
Blood prolactin increased	82.69	13.42	51	73311	3477	64421893
Hyperreflexia	82.46	13.42	67	73295	7081	64418289
Hypersensitivity	82.14	13.42	62	73300	196390	64228980
Product dose omission issue	82.02	13.42	61	73301	194686	64230684
Urticaria	81.07	13.42	33	73329	147284	64278086
Opisthotonus	80.91	13.42	30	73332	641	64424729
Drug level increased	80.85	13.42	142	73220	34054	64391316
Asthenia	78.95	13.42	238	73124	427806	63997564
Myocarditis	77.01	13.42	96	73266	16947	64408423
Arthritis	75.65	13.42	5	73357	83809	64341561
Mental impairment	75.36	13.42	93	73269	16250	64409120
Oromandibular dystonia	75.33	13.42	31	73331	882	64424488
Urinary retention	74.94	13.42	170	73192	49031	64376339
Antipsychotic drug level increased	74.39	13.42	55	73307	5060	64420310
Speech disorder	73.37	13.42	167	73195	48274	64377096
White blood cell count increased	73.10	13.42	202	73160	65812	64359558
Drug intolerance	72.78	13.42	64	73298	187928	64237442
Abdominal pain upper	72.19	13.42	56	73306	174974	64250396
Negativism	70.25	13.42	28	73334	732	64424638
Myoclonus	69.63	13.42	112	73250	25006	64400364
Drug abuse	68.28	13.42	315	73047	132059	64293311
Mental disorder	68.02	13.42	114	73248	26331	64399039
Chest discomfort	67.22	13.42	24	73338	116082	64309288
Contraindicated product administered	66.45	13.42	20	73342	107809	64317561
Disturbance in attention	66.01	13.42	145	73217	40929	64384441
Autonomic nervous system imbalance	65.94	13.42	47	73315	4085	64421285
Psoriasis	65.54	13.42	4	73358	71699	64353671
Encephalitis autoimmune	64.91	13.42	35	73327	1849	64423521
Incorrect route of product administration	64.74	13.42	104	73258	23194	64402176
Mental status changes	64.62	13.42	184	73178	60978	64364392
Anaemia	64.58	13.42	218	73144	378462	64046908
Cardiac failure congestive	64.48	13.42	34	73328	130546	64294824
Waxy flexibility	64.20	13.42	20	73342	245	64425125
Protrusion tongue	63.95	13.42	22	73340	375	64424995
Cardiac arrest	63.46	13.42	344	73018	153720	64271650
Antipsychotic drug level below therapeutic	63.25	13.42	28	73334	957	64424413
Spasmodic dysphonia	62.88	13.42	18	73344	161	64425209
Herpes zoster	62.75	13.42	8	73354	79179	64346191
Echolalia	61.70	13.42	21	73341	346	64425024
Pleurothotonus	60.98	13.42	36	73326	2266	64423104
Hyponatraemia	60.95	13.42	331	73031	148008	64277362
Sudden death	60.40	13.42	93	73269	20003	64405367
Leukocytosis	59.26	13.42	132	73230	37608	64387762
Intestinal pseudo-obstruction	57.54	13.42	33	73329	1967	64423403
Influenza	56.78	13.42	25	73337	106506	64318864
Asthma	56.29	13.42	19	73343	95206	64330164
Priapism	56.19	13.42	42	73320	3928	64421442
Musculoskeletal pain	56.01	13.42	12	73350	81282	64344088
Wound	55.40	13.42	10	73352	76467	64348903
Chest pain	55.25	13.42	116	73246	235864	64189506
Visceral congestion	54.83	13.42	24	73338	798	64424572
Injection site erythema	54.09	13.42	8	73354	70792	64354578
Unresponsive to stimuli	51.68	13.42	150	73212	50243	64375127
Stereotypy	51.07	13.42	23	73339	819	64424551
Intentional product misuse	50.60	13.42	189	73173	72106	64353264
Hypoaesthesia	49.56	13.42	51	73311	139057	64286313
Miosis	49.49	13.42	68	73294	13198	64412172
Electrocardiogram J wave	49.33	13.42	12	73350	52	64425318
Disinhibition	48.98	13.42	31	73331	2212	64423158
Osteoarthritis	48.75	13.42	7	73355	63329	64362041
Irritability	48.40	13.42	120	73242	36626	64388744
Paraesthesia	48.29	13.42	49	73313	134473	64290897
Hallucinations, mixed	48.27	13.42	46	73316	6006	64419364
Delusion of grandeur	48.24	13.42	20	73342	580	64424790
Impaired healing	48.18	13.42	6	73356	60467	64364903
Hypernatraemia	47.78	13.42	64	73298	12125	64413245
Product packaging issue	47.74	13.42	23	73339	957	64424413
Refusal of treatment by patient	47.69	13.42	53	73309	8286	64417084
Leukopenia	47.17	13.42	234	73128	101008	64324362
Neutrophil count increased	46.40	13.42	94	73268	25080	64400290
Weight decreased	46.31	13.42	168	73194	285571	64139799
Erythema	46.31	13.42	89	73273	186981	64238389
Stomatitis	45.26	13.42	35	73327	109570	64315800
Malaise	45.20	13.42	265	73097	395982	64029388
Generalised tonic-clonic seizure	45.15	13.42	123	73239	39734	64385636
Obsessive-compulsive disorder	45.00	13.42	40	73322	4778	64420592
Nasal congestion	44.98	13.42	7	73355	59651	64365719
Epistaxis	44.94	13.42	28	73334	98103	64327267
Lethargy	44.48	13.42	182	73180	72412	64352958
Myalgia	44.22	13.42	70	73292	158547	64266823
Self-injurious ideation	43.43	13.42	33	73329	3164	64422206
Interstitial lung disease	43.24	13.42	29	73333	97703	64327667
Reduced facial expression	43.16	13.42	28	73334	2085	64423285
Discomfort	43.06	13.42	19	73343	80859	64344511
Encephalitis toxic	42.54	13.42	15	73347	276	64425094
Bronchitis	42.09	13.42	37	73325	108706	64316664
Inappropriate antidiuretic hormone secretion	42.00	13.42	84	73278	22205	64403165
Gestational diabetes	41.78	13.42	41	73321	5549	64419821
Psychiatric decompensation	41.58	13.42	29	73333	2434	64422936
Thinking abnormal	41.26	13.42	58	73304	11498	64413872
Hyperammonaemic encephalopathy	40.53	13.42	35	73327	4023	64421347
Coma scale abnormal	40.37	13.42	47	73315	7727	64417643
Blunted affect	40.37	13.42	16	73346	412	64424958
Myocardial infarction	40.08	13.42	80	73282	165741	64259629
Euphoric mood	39.62	13.42	43	73319	6548	64418822
Tachypnoea	39.56	13.42	91	73271	26480	64398890
Parotitis	39.45	13.42	27	73335	2198	64423172
Choking	39.28	13.42	54	73308	10484	64414886
Bradycardia	38.98	13.42	249	73113	117970	64307400
Huntington's disease	38.93	13.42	8	73354	12	64425358
Fluid retention	38.68	13.42	10	73352	59596	64365774
Trismus	38.61	13.42	37	73325	4864	64420506
Parkinsonian gait	38.58	13.42	19	73343	830	64424540
Febrile neutropenia	38.48	13.42	99	73263	187558	64237812
Akinesia	37.94	13.42	30	73332	3049	64422321
Psychosexual disorder	37.15	13.42	11	73351	112	64425258
Eye movement disorder	37.10	13.42	43	73319	7036	64418334
Contusion	37.07	13.42	45	73317	113920	64311450
Nuchal rigidity	36.46	13.42	19	73343	936	64424434
Colitis ischaemic	36.07	13.42	59	73303	13355	64412015
Diet refusal	35.95	13.42	18	73344	815	64424555
Accidental exposure to product	35.68	13.42	87	73275	26277	64399093
Flight of ideas	35.59	13.42	17	73345	694	64424676
Blood pressure increased	35.40	13.42	91	73271	172461	64252909
Dementia	35.29	13.42	75	73287	20691	64404679
Flushing	35.25	13.42	23	73339	78625	64346745
Prescribed overdose	35.22	13.42	74	73288	20257	64405113
Oedema peripheral	35.16	13.42	122	73240	210195	64215175
Impulsive behaviour	35.10	13.42	27	73335	2636	64422734
Seizure	34.98	13.42	316	73046	166576	64258794
Chorea	34.83	13.42	24	73338	1976	64423394
Agranulocytosis	34.68	13.42	109	73253	38120	64387250
Pulmonary embolism	34.27	13.42	284	73078	146072	64279298
Distractibility	34.03	13.42	16	73346	630	64424740
Hypersexuality	33.70	13.42	21	73341	1458	64423912
Hallucination, visual	33.65	13.42	88	73274	27746	64397624
Sexual dysfunction	33.40	13.42	39	73323	6432	64418938
Feeling guilty	33.23	13.42	17	73345	806	64424564
Compulsive sexual behaviour	33.20	13.42	12	73350	238	64425132
Peptostreptococcus infection	33.13	13.42	9	73353	65	64425305
Burning sensation	32.87	13.42	8	73354	49656	64375714
Intentional product use issue	32.80	13.42	36	73326	95328	64330042
Oral discharge	32.74	13.42	12	73350	248	64425122
Helicobacter infection	32.61	13.42	3	73359	38359	64387011
Gastrooesophageal reflux disease	32.52	13.42	28	73334	83115	64342255
Illogical thinking	32.44	13.42	9	73353	71	64425299
Aspiration	32.26	13.42	64	73298	16821	64408549
Differential white blood cell count abnormal	32.18	13.42	22	73340	1788	64423582
Injection site reaction	31.91	13.42	7	73355	46657	64378713
Cerebrovascular accident	31.87	13.42	68	73294	137515	64287855
Bruxism	31.70	13.42	29	73333	3595	64421775
Sinus tachycardia	31.27	13.42	94	73268	32094	64393276
Muscle contractions involuntary	30.63	13.42	27	73335	3190	64422180
Multiple sclerosis relapse	30.62	13.42	5	73357	41130	64384240
Haematochezia	30.30	13.42	19	73343	66354	64359016
Pyramidal tract syndrome	30.19	13.42	14	73348	534	64424836
Withdrawal syndrome	30.18	13.42	76	73286	23416	64401954
Somatic symptom disorder of pregnancy	30.11	13.42	9	73353	95	64425275
Hyperhidrosis	30.10	13.42	244	73118	124676	64300694
Patient restraint	30.02	13.42	9	73353	96	64425274
Posturing	29.93	13.42	17	73345	995	64424375
Neuropathy peripheral	29.87	13.42	55	73307	117470	64307900
Epilepsy	29.86	13.42	95	73267	33436	64391934
Dyspnoea exertional	29.86	13.42	24	73338	73706	64351664
Grandiosity	29.78	13.42	14	73348	551	64424819
Dementia with Lewy bodies	29.70	13.42	15	73347	692	64424678
Apathy	29.66	13.42	49	73313	11183	64414187
Resting tremor	29.53	13.42	19	73343	1395	64423975
Floppy iris syndrome	29.44	13.42	12	73350	333	64425037
Inflammation	29.39	13.42	19	73343	65281	64360089
Therapeutic product effect decreased	29.30	13.42	54	73308	115297	64310073
Cardio-respiratory arrest	29.26	13.42	202	73160	98191	64327179
Tic	29.06	13.42	24	73338	2595	64422775
Decreased appetite	29.00	13.42	194	73168	281095	64144275
Negative symptoms in schizophrenia	28.84	13.42	9	73353	111	64425259
Drug hypersensitivity	28.72	13.42	156	73206	237659	64187711
Injection site swelling	28.69	13.42	6	73356	41347	64384023
Antidepressant drug level increased	28.63	13.42	12	73350	358	64425012
Sinus bradycardia	28.31	13.42	73	73289	22820	64402550
Pain in jaw	28.10	13.42	6	73356	40749	64384621
Dyspepsia	27.97	13.42	30	73332	80282	64345088
HIV peripheral neuropathy	27.96	13.42	7	73355	35	64425335
Oropharyngeal pain	27.94	13.42	36	73326	88831	64336539
Electroencephalogram abnormal	27.93	13.42	32	73330	5171	64420199
Gastrointestinal haemorrhage	27.73	13.42	69	73293	132243	64293127
Infection	27.17	13.42	113	73249	184767	64240603
Acute psychosis	27.08	13.42	27	73335	3725	64421645
Toxic epidermal necrolysis	26.69	13.42	98	73264	37068	64388302
Behaviour disorder	26.62	13.42	29	73333	4433	64420937
Tension	26.55	13.42	27	73335	3813	64421557
Urinary incontinence	26.54	13.42	96	73266	36055	64389315
Psychomotor skills impaired	26.53	13.42	27	73335	3818	64421552
Delusional disorder, unspecified type	26.33	13.42	14	73348	719	64424651
Circadian rhythm sleep disorder	26.16	13.42	13	73349	579	64424791
Water intoxication	26.03	13.42	14	73348	736	64424634
Hypokinesia	25.99	13.42	58	73304	16538	64408832
Sexually inappropriate behaviour	25.92	13.42	12	73350	456	64424914
Medication error	25.80	13.42	119	73243	49847	64375523
Dry skin	25.72	13.42	13	73349	51148	64374222
Ill-defined disorder	25.67	13.42	9	73353	44043	64381327
Cardiomyopathy alcoholic	25.60	13.42	7	73355	52	64425318
Palpitations	25.59	13.42	50	73312	104438	64320932
Eye pain	25.53	13.42	3	73359	31622	64393748
Communication disorder	25.52	13.42	26	73336	3680	64421690
Night sweats	25.49	13.42	5	73357	36041	64389329
Respiratory failure	25.49	13.42	288	73074	160895	64264475
Hyporesponsive to stimuli	25.41	13.42	19	73343	1778	64423592
Illusion	25.38	13.42	18	73344	1552	64423818
Speech sound disorder	25.37	13.42	7	73355	54	64425316
Treatment failure	25.20	13.42	60	73302	116756	64308614
Blood pressure fluctuation	24.87	13.42	14	73348	51857	64373513
Pressure of speech	24.81	13.42	15	73347	986	64424384
Psychiatric symptom	24.68	13.42	33	73329	6240	64419130
Drop attacks	24.62	13.42	15	73347	1000	64424370
Muscle contracture	24.52	13.42	20	73342	2125	64423245
Staring	24.50	13.42	21	73341	2389	64422981
Eosinophilic myocarditis	24.36	13.42	14	73348	838	64424532
Blood prolactin abnormal	24.17	13.42	22	73340	2710	64422660
Diverticulitis	24.08	13.42	7	73355	38611	64386759
Haemorrhage	24.08	13.42	33	73329	79318	64346052
Coronary artery disease	24.06	13.42	20	73342	60413	64364957
Clonus	24.00	13.42	32	73330	6035	64419335
Wheezing	23.96	13.42	34	73328	80545	64344825
Osteoporosis	23.83	13.42	9	73353	42071	64383299
Cellulitis	23.65	13.42	44	73318	93613	64331757
Clostridium difficile infection	23.59	13.42	6	73356	36157	64389213
Dysphoria	23.58	13.42	27	73335	4361	64421009
Polydipsia	23.48	13.42	31	73331	5790	64419580
Pericarditis	23.31	13.42	22	73340	62494	64362876
Hallucination, olfactory	23.14	13.42	11	73351	444	64424926
Atrial fibrillation	23.06	13.42	108	73254	170981	64254389
Delusion of reference	22.95	13.42	8	73354	142	64425228
Neurotoxicity	22.92	13.42	76	73286	27328	64398042
Rapid eye movement sleep behaviour disorder	22.89	13.42	10	73352	331	64425039
Rash pruritic	22.85	13.42	19	73343	57385	64367985
Influenza like illness	22.68	13.42	22	73340	61680	64363690
Feeling abnormal	22.65	13.42	77	73285	133525	64291845
Anticholinergic syndrome	22.65	13.42	21	73341	2648	64422722
Antipsychotic drug level above therapeutic	22.65	13.42	18	73344	1843	64423527
Ventricular fibrillation	22.54	13.42	69	73293	23791	64401579
Body temperature increased	22.51	13.42	92	73270	36574	64388796
Somatic hallucination	22.51	13.42	6	73356	40	64425330
Nephrogenic diabetes insipidus	22.43	13.42	18	73344	1869	64423501
Postoperative respiratory failure	22.35	13.42	8	73354	154	64425216
Respiratory depression	22.34	13.42	68	73294	23375	64401995
Hyperammonaemia	21.96	13.42	40	73322	9864	64415506
Disease progression	21.82	13.42	85	73277	141595	64283775
Thrombosis	21.81	13.42	29	73333	70613	64354757
Urinary tract infection	21.77	13.42	164	73198	231432	64193938
Localised infection	21.72	13.42	4	73358	30157	64395213
Poor personal hygiene	21.65	13.42	11	73351	514	64424856
Cataract	21.63	13.42	16	73346	51246	64374124
Pneumocystis jirovecii pneumonia	21.39	13.42	3	73359	27631	64397739
Inappropriate affect	21.36	13.42	15	73347	1273	64424097
Hepatic enzyme increased	21.29	13.42	76	73286	129867	64295503
Mydriasis	21.22	13.42	51	73311	15261	64410109
Rebound effect	21.10	13.42	27	73335	4890	64420480
Cytomegalovirus infection	20.99	13.42	8	73354	37191	64388179
Pneumonia	20.92	13.42	481	72881	559095	63866275
Haemoglobin decreased	20.86	13.42	133	73229	194930	64230440
Muscular weakness	20.51	13.42	75	73287	127263	64298107
Bone marrow eosinophilic leukocyte count increased	20.49	13.42	5	73357	22	64425348
Anaphylactic reaction	20.39	13.42	29	73333	68635	64356735
Electrocardiogram PR prolongation	20.36	13.42	15	73347	1372	64423998
Basal cell carcinoma	20.34	13.42	5	73357	30833	64394537
Increased appetite	20.04	13.42	39	73323	10107	64415263
Haemoglobin urine	19.99	13.42	7	73355	126	64425244
Obesity	19.93	13.42	60	73302	20502	64404868
Bone pain	19.88	13.42	15	73347	47557	64377813
False positive investigation result	19.85	13.42	12	73350	789	64424581
Cystitis	19.78	13.42	12	73350	42663	64382707
Self-medication	19.78	13.42	24	73338	4121	64421249
Abdominal pain	19.69	13.42	244	73118	312131	64113239
Myocardial reperfusion injury	19.65	13.42	5	73357	27	64425343
Folliculitis	19.60	13.42	5	73357	30072	64395298
Cerebral atrophy	19.53	13.42	32	73330	7253	64418117
Echopraxia	19.50	13.42	5	73357	28	64425342
Completed suicide	19.46	13.42	361	73001	224053	64201317
Screaming	19.44	13.42	22	73340	3507	64421863
Brain injury	19.31	13.42	38	73324	9927	64415443
Apallic syndrome	19.08	13.42	12	73350	847	64424523
Allergic hepatitis	19.07	13.42	5	73357	31	64425339
Femoral neck fracture	19.05	13.42	35	73327	8689	64416681
Physical assault	18.91	13.42	15	73347	1531	64423839
Lactate pyruvate ratio increased	18.87	13.42	6	73356	79	64425291
Encephalopathy	18.83	13.42	123	73239	58696	64366674
Drug withdrawal syndrome	18.80	13.42	78	73284	31213	64394157
Gastric disorder	18.75	13.42	5	73357	29192	64396178
Visual acuity reduced	18.70	13.42	4	73358	27137	64398233
Dry eye	18.58	13.42	5	73357	29014	64396356
Unevaluable event	18.56	13.42	18	73344	50471	64374899
Stress	18.54	13.42	25	73337	60509	64364861
Hyperthermia malignant	18.31	13.42	18	73344	2441	64422929
Drug diversion	18.31	13.42	13	73349	1123	64424247
Wrong patient received product	18.30	13.42	22	73340	3740	64421630
Fungal infection	18.30	13.42	8	73354	34243	64391127
Disorganised speech	18.06	13.42	15	73347	1635	64423735
Electroconvulsive therapy	18.03	13.42	6	73356	92	64425278
Anaphylactic shock	18.01	13.42	6	73356	30322	64395048
Amenorrhoea	17.90	13.42	29	73333	6510	64418860
COVID-19	17.90	13.42	29	73333	65111	64360259
Refusal of examination	17.85	13.42	6	73356	95	64425275
Lower respiratory tract infection	17.82	13.42	52	73310	94562	64330808
Osteonecrosis	17.82	13.42	5	73357	28224	64397146
Surgery	17.80	13.42	5	73357	28208	64397162
Heart rate decreased	17.63	13.42	22	73340	55045	64370325
Faecaloma	17.54	13.42	36	73326	9692	64415678
Haematuria	17.50	13.42	26	73336	60445	64364925
Pituitary tumour benign	17.48	13.42	17	73345	2276	64423094
Snoring	17.46	13.42	24	73338	4658	64420712
Exhibitionism	17.34	13.42	5	73357	46	64425324
Primary familial brain calcification	17.34	13.42	3	73359	0	64425370
Myelodysplastic syndrome	17.19	13.42	5	73357	27574	64397796
Rhinorrhoea	17.15	13.42	26	73336	59943	64365427
Metabolic syndrome	17.14	13.42	17	73345	2331	64423039
Gastrointestinal disorder	17.11	13.42	49	73313	89660	64335710
Mobility decreased	17.03	13.42	46	73316	85794	64339576
Oedema	16.97	13.42	51	73311	91884	64333486
Logorrhoea	16.97	13.42	22	73340	4037	64421333
Pulmonary arterial hypertension	16.95	13.42	4	73358	25363	64400007
Polydipsia psychogenic	16.95	13.42	7	73355	201	64425169
Gender dysphoria	16.88	13.42	5	73357	51	64425319
Upper respiratory tract infection	16.82	13.42	36	73326	72749	64352621
Nephrolithiasis	16.73	13.42	15	73347	43668	64381702
Ulcer	16.66	13.42	3	73359	22987	64402383
Angina pectoris	16.65	13.42	16	73346	45065	64380305
Judgement impaired	16.65	13.42	12	73350	1061	64424309
Vascular stenosis	16.59	13.42	9	73353	481	64424889
Swelling face	16.58	13.42	26	73336	59140	64366230
Grimacing	16.58	13.42	10	73352	655	64424715
Dyslipidaemia	16.43	13.42	34	73328	9208	64416162
Haemoptysis	16.33	13.42	19	73343	49029	64376341
Device issue	16.31	13.42	3	73359	22645	64402725
Duodenal stenosis	16.26	13.42	10	73352	678	64424692
Blood citric acid increased	16.22	13.42	5	73357	59	64425311
Paraphilia	16.14	13.42	5	73357	60	64425310
Tooth disorder	16.07	13.42	3	73359	22399	64402971
Therapeutic product effect variable	16.06	13.42	14	73348	1630	64423740
Visual impairment	16.01	13.42	38	73324	74039	64351331
Hypoxic-ischaemic encephalopathy	16.00	13.42	29	73333	7123	64418247
Drug ineffective for unapproved indication	15.96	13.42	74	73288	31059	64394311
Injection site haemorrhage	15.89	13.42	4	73358	24274	64401096
Anxiety	15.87	13.42	321	73041	202328	64223042
Perseveration	15.74	13.42	8	73354	374	64424996
Tonic clonic movements	15.64	13.42	15	73347	1974	64423396
Red blood cell sedimentation rate increased	15.61	13.42	8	73354	31227	64394143
Illness	15.60	13.42	3	73359	21935	64403435
Impaired self-care	15.52	13.42	16	73346	2297	64423073
Loss of consciousness	15.51	13.42	246	73116	148119	64277251
Chills	15.50	13.42	92	73270	137172	64288198
Myelosuppression	15.46	13.42	4	73358	23826	64401544
Neutropenia	15.41	13.42	369	72993	239255	64186115
Verbal abuse	15.34	13.42	7	73355	257	64425113
Hot flush	15.30	13.42	18	73344	46217	64379153
Tongue biting	15.23	13.42	14	73348	1746	64423624
Cerebrovascular stenosis	15.23	13.42	6	73356	152	64425218
Accidental overdose	15.22	13.42	77	73285	33480	64391890
Epileptic encephalopathy	15.21	13.42	8	73354	402	64424968
Poverty of speech	15.19	13.42	9	73353	570	64424800
Hypotonia	15.17	13.42	37	73325	11175	64414195
Bursitis	15.15	13.42	3	73359	21482	64403888
Posture abnormal	15.09	13.42	19	73343	3387	64421983
Mental disorder due to a general medical condition	15.00	13.42	7	73355	271	64425099
Substance-induced psychotic disorder	14.88	13.42	17	73345	2738	64422632
Skin discolouration	14.88	13.42	11	73351	35244	64390126
Osteonecrosis of jaw	14.87	13.42	14	73348	39811	64385559
Incoherent	14.84	13.42	28	73334	7090	64418280
Transient ischaemic attack	14.84	13.42	17	73345	44165	64381205
Presyncope	14.74	13.42	11	73351	35078	64390292
Scrotal haematoma	14.71	13.42	5	73357	82	64425288
Colitis ulcerative	14.68	13.42	4	73358	23024	64402346
Neoplasm progression	14.60	13.42	15	73347	40949	64384421
Vascular dementia	14.59	13.42	10	73352	816	64424554
Neck pain	14.59	13.42	30	73332	61503	64363867
Abdominal distension	14.51	13.42	58	73304	95936	64329434
Tachyphrenia	14.47	13.42	14	73348	1862	64423508
Eosinophilia	14.31	13.42	83	73279	37993	64387377
Hyperkinesia	14.25	13.42	16	73346	2530	64422840
Pulmonary hypertension	14.06	13.42	17	73345	43122	64382248
Hypomania	14.04	13.42	24	73338	5630	64419740
Intestinal dilatation	14.01	13.42	15	73347	2249	64423121
Eye swelling	13.96	13.42	4	73358	22277	64403093
Productive cough	13.95	13.42	40	73322	73163	64352207
Cyanosis	13.92	13.42	56	73306	22099	64403271
Diabetic coma	13.89	13.42	11	73351	1120	64424250
Affective disorder	13.86	13.42	26	73336	6554	64418816
Feeling hot	13.84	13.42	19	73343	45644	64379726
Oral herpes	13.84	13.42	4	73358	22148	64403222
Dysgeusia	13.84	13.42	20	73342	47027	64378343
Breathing-related sleep disorder	13.81	13.42	6	73356	196	64425174
Oral pain	13.80	13.42	7	73355	27486	64397884
Depressive symptom	13.78	13.42	21	73341	4475	64420895
Exposure to extreme temperature	13.74	13.42	3	73359	7	64425363
Dyspnoea paroxysmal nocturnal	13.69	13.42	14	73348	1990	64423380
Blood glucose	13.67	13.42	4	73358	39	64425331
Product dispensing error	13.63	13.42	36	73326	11414	64413956
Carnitine deficiency	13.61	13.42	6	73356	203	64425167
Blood pressure systolic increased	13.60	13.42	22	73340	49431	64375939
Polyneuropathy	13.57	13.42	3	73359	19891	64405479
Compulsions	13.54	13.42	7	73355	339	64425031
Subileus	13.53	13.42	22	73340	4955	64420415
Slow speech	13.50	13.42	14	73348	2023	64423347

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	N05AD01	NERVOUS SYSTEM PSYCHOLEPTICS ANTIPSYCHOTICS Butyrophenone derivatives
MeSH PA	D018726	Anti-Dyskinesia Agents
MeSH PA	D000932	Antiemetics
MeSH PA	D014150	Antipsychotic Agents
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D002492	Central Nervous System Depressants
MeSH PA	D015259	Dopamine Agents
MeSH PA	D018492	Dopamine Antagonists
MeSH PA	D005765	Gastrointestinal Agents
MeSH PA	D018377	Neurotransmitter Agents
MeSH PA	D018373	Peripheral Nervous System Agents
MeSH PA	D011619	Psychotropic Drugs
MeSH PA	D014149	Tranquilizing Agents
CHEBI has role	CHEBI:48279	serotonin antagonists
CHEBI has role	CHEBI:48561	dopaminergic antagonists
CHEBI has role	CHEBI:50919	antiemetico
CHEBI has role	CHEBI:65190	typical antipsychotic drugs
CHEBI has role	CHEBI:66956	antidyskinetic agent
FDA EPC	N0000180182	Typical Antipsychotic

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Gilles de la Tourette's syndrome	indication	5158005	DOID:11119
Schizophrenia	indication	58214004	DOID:5419
Psychotic disorder	indication	69322001
Chronic schizophrenia	indication	83746006
Delirium	off-label use	2776000
Nausea and vomiting	off-label use	16932000
Pain	off-label use	22253000
Anxiety disorder	off-label use	197480006	DOID:2030
Headache disorder	off-label use	230461009
Gastroparesis	off-label use	235675006
Chemotherapy-induced nausea and vomiting	off-label use	236084000
Neuroleptic malignant syndrome	contraindication	15244003	DOID:14464
Senile dementia	contraindication	15662003
Agranulocytosis	contraindication	17182001	DOID:12987
Thyrotoxic crisis	contraindication	29028009	DOID:12837
Torsades de pointes	contraindication	31722008
Parkinsonism	contraindication	32798002
Hypothyroidism	contraindication	40930008	DOID:1459
Hypokalemia	contraindication	43339004
Low blood pressure	contraindication	45007003
Extrapyramidal disease	contraindication	76349003
Leukopenia	contraindication	84828003	DOID:615
Tardive dyskinesia	contraindication	102449007
Prolonged QT interval	contraindication	111975006
Seizure disorder	contraindication	128613002
Hypomagnesemia	contraindication	190855004
Angina pectoris	contraindication	194828000
Disease of liver	contraindication	235856003	DOID:409
Retention of urine	contraindication	267064002
Neutropenic disorder	contraindication	303011007	DOID:1227
Coma	contraindication	371632003
Breastfeeding (mother)	contraindication	413712001
Central nervous system depression	contraindication	418072004
Acquired torsion dystonia	contraindication	433493000
Congenital long QT syndrome	contraindication	442917000
Carcinoma of female breast	contraindication	447782002
Smokes tobacco daily	contraindication	449868002
Drug Induced CNS Depression	contraindication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	8.36	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
D(2) dopamine receptor	GPCR	P14416	DRD2_HUMAN	INVERSE AGONIST	Ki	9.15	WOMBAT-PK	CHEMBL
Beta-2 adrenergic receptor	GPCR	P07550	ADRB2_HUMAN		Ki	5.30	PDSP
Mu-type opioid receptor	GPCR	P35372	OPRM_HUMAN		Ki	6.00	DRUG MATRIX
D(1A) dopamine receptor	GPCR	P21728	DRD1_HUMAN		Ki	7.82	WOMBAT-PK
Alpha-2A adrenergic receptor	GPCR	P08913	ADA2A_HUMAN		Ki	5.95	PDSP
Sigma non-opioid intracellular receptor 1	Membrane receptor	Q99720	SGMR1_HUMAN		EC50	8.92	WOMBAT-PK
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	Enzyme	Q15125	EBP_HUMAN		Ki	6.72	WOMBAT-PK
Multidrug resistance protein 1	Transporter	P08183	MDR1_HUMAN		Ki	6.70	WOMBAT-PK
Sodium-dependent serotonin transporter	Transporter	P31645	SC6A4_HUMAN		Ki	5.74	CHEMBL
Sodium-dependent noradrenaline transporter	Transporter	P23975	SC6A2_HUMAN		Ki	5.74	DRUG MATRIX
5-hydroxytryptamine receptor 1A	GPCR	P08908	5HT1A_HUMAN		Ki	5.55	CHEMBL
5-hydroxytryptamine receptor 2A	GPCR	P28223	5HT2A_HUMAN	ANTAGONIST	Ki	7	WOMBAT-PK
5-hydroxytryptamine receptor 2B	GPCR	P41595	5HT2B_HUMAN		Ki	6.10	WOMBAT-PK
5-hydroxytryptamine receptor 2C	GPCR	P28335	5HT2C_HUMAN		Ki	5.33	CHEMBL
5-hydroxytryptamine receptor 6	GPCR	P50406	5HT6R_HUMAN		Ki	5.22	CHEMBL
5-hydroxytryptamine receptor 7	GPCR	P34969	5HT7R_HUMAN		Ki	6.45	WOMBAT-PK
Alpha-1A adrenergic receptor	GPCR	P35348	ADA1A_HUMAN		Ki	7.90	WOMBAT-PK
Alpha-2B adrenergic receptor	GPCR	P18089	ADA2B_HUMAN		Ki	6.32	PDSP
D(3) dopamine receptor	GPCR	P35462	DRD3_HUMAN	INVERSE AGONIST	Ki	8.52	WOMBAT-PK
D(1B) dopamine receptor	GPCR	P21918	DRD5_HUMAN		Ki	7.52	WOMBAT-PK
Histamine H1 receptor	GPCR	P35367	HRH1_HUMAN		Ki	6.36	CHEMBL
Histamine H2 receptor	GPCR	P25021	HRH2_HUMAN		Ki	6.00	PDSP
Muscarinic acetylcholine receptor M1	GPCR	P11229	ACM1_HUMAN		Ki	5.80	CHEMBL
Muscarinic acetylcholine receptor M3	GPCR	P20309	ACM3_HUMAN		Ki	5	PDSP
Muscarinic acetylcholine receptor M5	GPCR	P08912	ACM5_HUMAN		Ki	6.18	PDSP
5-hydroxytryptamine receptor 1B	GPCR	P28222	5HT1B_HUMAN		Ki	6.57	PDSP
5-hydroxytryptamine receptor 1D	GPCR	P28221	5HT1D_HUMAN	ANTAGONIST	Ki	6.60	IUPHAR
Alpha-2C adrenergic receptor	GPCR	P18825	ADA2C_HUMAN		Ki	6.26	PDSP
Alpha-1D adrenergic receptor	GPCR	P25100	ADA1D_HUMAN		Ki	7.55	DRUG MATRIX
Alpha-1B adrenergic receptor	GPCR	P35368	ADA1B_HUMAN		Ki	8.10	PDSP
Calmodulin	Cytosolic other	P0DP23 P0DP24 P0DP25	CALM1_HUMAN CALM2_HUMAN CALM3_HUMAN		IC50	6.30	WOMBAT-PK
5-hydroxytryptamine receptor 5A	GPCR	P47898	5HT5A_HUMAN		Ki	5.65	PDSP
5-hydroxytryptamine receptor 1F	GPCR	P30939	5HT1F_HUMAN		Ki	5.30	PDSP
5-hydroxytryptamine receptor 1E	GPCR	P28566	5HT1E_HUMAN		Ki	5.30	PDSP
Potassium channel subfamily K member 2	Ion channel	O95069	KCNK2_HUMAN		IC50	5.26	CHEMBL
Potassium voltage-gated channel subfamily H member 1	Ion channel	O95259	KCNH1_HUMAN	BLOCKER	IC50	6.20	IUPHAR
Sodium channel alpha subunits; brain (Types I, II, III)	Ion channel	P35498 Q99250 Q9NY46	SCN1A_HUMAN SCN2A_HUMAN SCN3A_HUMAN		IC50	5.92	CHEMBL
Histone H1.0	Nuclear other	P07305	H10_HUMAN		Ki	6.11	CHEMBL
Transmembrane protein 97	Enzyme	Q5BJF2	TMM97_HUMAN		Ki	7.80	CHEMBL
Potassium voltage-gated channel subfamily H member 2	Ion channel	Q12809	KCNH2_HUMAN		IC50	7.50	WOMBAT-PK
D(4) dopamine receptor	GPCR	P21917	DRD4_HUMAN	INVERSE AGONIST	Kd	9.42	SCIENTIFIC LITERATURE
Alpha-1B adrenergic receptor	GPCR		ADA1B_RAT		Ki	8.31	DRUG MATRIX
Membrane-associated progesterone receptor component 1	Membrane receptor		PGRC1_RAT		Ki	7.44	DRUG MATRIX
Pol polyprotein	Enzyme		Q72874_9HIV1		Ki	7	CHEMBL
Alpha-1A adrenergic receptor	GPCR		ADA1A_RAT		Kd	7.76	CHEMBL
Histamine H1 receptor	GPCR		HRH1_CAVPO		Ki	6.40	CHEMBL
Muscarinic acetylcholine receptor M2	GPCR		ACM2_RAT		Ki	6.62	CHEMBL
Muscarinic acetylcholine receptor M1	GPCR		ACM1_RAT		Ki	5.74	CHEMBL
D(2) dopamine receptor	GPCR		DRD2_RAT		Ki	9.70	CHEMBL
5-hydroxytryptamine receptor 1A	GPCR		5HT1A_RAT		Ki	6.40	CHEMBL
5-hydroxytryptamine receptor 2A	GPCR		5HT2A_RAT		Ki	7.35	CHEMBL
Sigma non-opioid intracellular receptor 1	Membrane receptor		SGMR1_RAT		Ki	9.05	CHEMBL
5-hydroxytryptamine receptor 7	GPCR		5HT7R_RAT		Ki	6.58	CHEMBL
5-hydroxytryptamine receptor 7	GPCR		5HT7R_MOUSE	ANTAGONIST	Ki	6.30	IUPHAR
D(1A) dopamine receptor	GPCR		DRD1_RAT		Ki	7.70	CHEMBL
D(2) dopamine receptor	GPCR		DRD2_BOVIN		Ki	9.52	CHEMBL
Alpha-1A adrenergic receptor	GPCR		ADA1A_BOVIN		IC50	7.70	CHEMBL
Histamine H1 receptor	GPCR		HRH1_RAT		Ki	6.42	CHEMBL
D(3) dopamine receptor	GPCR		DRD3_RAT		Ki	8.52	CHEMBL
Protease	Enzyme		Q4U254_9ENTO		Ki	7	CHEMBL
D(2) dopamine receptor	GPCR		DRD2_CHLAE		Ki	8.32	CHEMBL
5-hydroxytryptamine receptor 2A	GPCR		5HT2A_BOVIN		IC50	7.52	CHEMBL
C-8 sterol isomerase	Enzyme		ERG2_YEAST		Ki	9.30	CHEMBL
D(1A) dopamine receptor	GPCR		DRD1_PIG		Ki	7.03	CHEMBL
Sigma non-opioid intracellular receptor 1	Membrane other		SGMR1_CAVPO		Ki	9.08	CHEMBL
Transporter	Transporter		Q63380_RAT		Ki	5.26	CHEMBL
5-hydroxytryptamine receptor 2A	GPCR		5HT2A_PIG		Ki	7.52	CHEMBL
D(3) dopamine receptor	GPCR		DRD3_CHLAE		Ki	8.52	CHEMBL
Vesicular acetylcholine transporter	Transporter		VACHT_RAT		Ki	6.41	CHEMBL
AP-2 complex subunit sigma	Unclassified		AP2S1_RAT		Ki	7.62	CHEMBL
Muscarinic acetylcholine receptor	GPCR		ACM1_RAT ACM3_RAT ACM4_RAT ACM5_RAT ACM2_RAT		Ki	5.13	CHEMBL
Opioid receptor	GPCR		OPRD_RAT OPRM_RAT OPRK_RAT SGMR1_RAT		Ki	5.92	CHEMBL
Serotonin 1 (5-HT1) receptor	GPCR		5HT1A_RAT 5HT1B_RAT 5HT1D_RAT 5HT1F_RAT		IC50	4.70	CHEMBL
Adrenergic receptor alpha-2	GPCR		ADA2B_RAT ADA2C_RAT ADA2A_RAT		Ki	5.57	CHEMBL
Dopamine receptor	GPCR		DRD2_BOVIN DRD1_BOVIN		IC50	8.74	CHEMBL
Dopamine receptor	GPCR		DRD1_RAT DRD3_RAT DRD5_RAT DRD4_RAT DRD2_RAT		Ki	8.70	CHEMBL
Serotonin 2 (5-HT2) receptor	GPCR		5HT2C_RAT 5HT2A_RAT 5HT2B_RAT		Ki	8.38	CHEMBL
Adenylate cyclase	Enzyme		D4A3N4_RAT ADCY3_RAT ADCY2_RAT ADCY4_RAT ADCY8_RAT ADCY6_RAT ADCY5_RAT Q8CFM9_RAT		IC50	5.64	CHEMBL
Serotonin 2 (5-HT2) receptor	GPCR		5HT2C_MOUSE 5HT2A_MOUSE 5HT2B_MOUSE		Ki	7.58	CHEMBL
G protein-activated inward rectifier potassium channel 2	Ion channel		KCNJ6_MOUSE	GATING INHIBITOR	EC50	4.10	IUPHAR
Sigma intracellular receptor 2	Unclassified		SGMR2_RAT		Ki	7.36	CHEMBL
Zinc finger protein 664	Unclassified		ZN664_CAVPO		Ki	8.18	CHEMBL

External reference:

ID	Source
4018123	VUID
N0000146461	NUI
D00136	KEGG_DRUG
53515-91-6	SECONDARY_CAS_RN
4018123	VANDF
4018125	VANDF
C0018546	UMLSCUI
CHEBI:5613	CHEBI
GMJ	PDB_CHEM_ID
CHEMBL54	ChEMBL_ID
DB00502	DRUGBANK_ID
CHEMBL2096643	ChEMBL_ID
CHEMBL4297147	ChEMBL_ID
D006220	MESH_DESCRIPTOR_UI
3559	PUBCHEM_CID
86	IUPHAR_LIGAND_ID
918	INN_ID
J6292F8L3D	UNII
217483	RXNORM
2958	MMSL
4816	MMSL
4818	MMSL
583	MMSL
d00027	MMSL
001518	NDDF
001521	NDDF
10756001	SNOMEDCT_US
386837002	SNOMEDCT_US
412197008	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0121-0581	SOLUTION	2 mg	ORAL	ANDA	17 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0121-0581	SOLUTION	2 mg	ORAL	ANDA	17 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9319	INJECTION	5 mg	INTRAMUSCULAR	ANDA	16 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9501	INJECTION	5 mg	INTRAMUSCULAR	ANDA	16 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9502	INJECTION	5 mg	INTRAMUSCULAR	ANDA	16 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0378-0214	TABLET	2 mg	ORAL	ANDA	17 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0378-0257	TABLET	1 mg	ORAL	ANDA	17 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0378-0327	TABLET	5 mg	ORAL	ANDA	17 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0378-0334	TABLET	10 mg	ORAL	ANDA	17 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0378-0335	TABLET	20 mg	ORAL	ANDA	17 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0378-0351	TABLET	0.50 mg	ORAL	ANDA	17 sections
Haloperidol Lactate	HUMAN PRESCRIPTION DRUG LABEL	1	0404-9871	INJECTION, SOLUTION	5 mg	INTRAMUSCULAR	ANDA	12 sections
Haloperidol Lactate	HUMAN PRESCRIPTION DRUG LABEL	1	0404-9871	INJECTION, SOLUTION	5 mg	INTRAMUSCULAR	ANDA	12 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8355	TABLET	5 mg	ORAL	ANDA	15 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0832-1510	TABLET	0.50 mg	ORAL	ANDA	15 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0832-1520	TABLET	1 mg	ORAL	ANDA	15 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0832-1530	TABLET	2 mg	ORAL	ANDA	15 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0832-1540	TABLET	5 mg	ORAL	ANDA	15 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0832-1550	TABLET	10 mg	ORAL	ANDA	15 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0832-1560	TABLET	20 mg	ORAL	ANDA	15 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0904-5923	TABLET	1 mg	ORAL	ANDA	18 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0904-5924	TABLET	2 mg	ORAL	ANDA	18 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0904-5925	TABLET	5 mg	ORAL	ANDA	18 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0904-6413	TABLET	10 mg	ORAL	ANDA	18 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0904-6661	TABLET	20 mg	ORAL	ANDA	15 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0904-6733	TABLET	10 mg	ORAL	ANDA	15 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0904-6782	TABLET	5 mg	ORAL	ANDA	15 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	0904-7112	SOLUTION	2 mg	ORAL	ANDA	13 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	17478-110	INJECTION	5 mg	INTRAMUSCULAR	ANDA	25 sections
Haloperidol	HUMAN PRESCRIPTION DRUG LABEL	1	17856-0501	SOLUTION	2 mg	ORAL	ANDA	13 sections