DrugCentral 2023 ๐
2022 Update-Veterinary Drugs & Uses
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Structure ๐
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L1000
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DrugCentral 2023 ๐
2022 Update-Veterinary Drugs & Uses
Search
Structure ๐
Similarity ๐
Smart API
Redial
About
Download
L1000
FAQ
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FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
guanadrel ๐ถ
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
antihypertensives, guanidine derivatives
1339
40580-59-4
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
hylorel
guanadrel
guanadrel sulfate
Molecular weight: 213.28
Formula: C10H19N3O2
CLOGP: 0.80
LIPINSKI: 0
HAC: 5
HDO: 3
TPSA: 80.36
ALOGS: -2.09
ROTB: 2
Status: OFM
Legend:
OFP - off patent
OFM - off market
ONP - on patent
Drug dosage:
None
ADMET properties:
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Property
Value
Reference
BA (Bioavailability)
85 %
Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
MRTD (Maximum Recommended Therapeutic Daily Dose)
18.48 ยตM/kg/day
Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
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Approvals:
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Date
Agency
Company
Orphan
Dec. 29, 1982
FDA
PHARMACIA AND UPJOHN
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FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
CHEBI has role
CHEBI:35674
antihypertensive drugs
CHEBI has role
CHEBI:37887
adrenergic blockers
MeSH PA
D000959
Antihypertensive Agents
MeSH PA
D002317
Cardiovascular Agents
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
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Disease
Relation
SNOMED_ID
DOID
Hypertensive disorder
indication
38341003
DOID:10763
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๐ถ Veterinary Drug Use
None
๐ถ Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
9.82
Basic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Sodium-dependent noradrenaline transporter
Transporter
P23975
SC6A2_HUMAN
SUBSTRATE
DRUGBANK
CHEMBL
Alpha-1A adrenergic receptor
GPCR
P35348
ADA1A_HUMAN
WOMBAT-PK
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External reference:
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entries
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ID
Source
000641
NDDF
004494
NDDF
14013006
SNOMEDCT_US
1821
MMSL
217653
RXNORM
22195-34-2
SECONDARY_CAS_RN
2590
INN_ID
372820001
SNOMEDCT_US
38521
PUBCHEM_CID
4018079
VANDF
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Pharmaceutical products:
None
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guanadrel