Stem definition | Drug id | CAS RN |
---|---|---|
1336 | 93-14-1 |
Dose | Unit | Route |
---|---|---|
0.90 | g | O |
0.90 | g | P |
Property | Value | Reference |
---|---|---|
S (Water solubility) | 40.40 mg/mL | Bocci G, Oprea TI, Benet LZ |
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Bocci G, Oprea TI, Benet LZ |
Date | Agency | Company | Orphan |
---|---|---|---|
July 12, 2002 | FDA | RECKITT BENCKISER |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Irritable bowel syndrome | 492.20 | 9.88 | 1094 | 272788 | 81318 | 63133822 |
Sinusitis | 490.78 | 9.88 | 2107 | 271775 | 224546 | 62990594 |
Muscle injury | 483.26 | 9.88 | 947 | 272935 | 64398 | 63150742 |
Folliculitis | 478.14 | 9.88 | 984 | 272898 | 69333 | 63145807 |
Lower respiratory tract infection | 456.45 | 9.88 | 1431 | 272451 | 130876 | 63084264 |
Drug interaction | 451.16 | 9.88 | 212 | 273670 | 228919 | 62986221 |
Nasopharyngitis | 416.43 | 9.88 | 2180 | 271702 | 252077 | 62963063 |
Peripheral swelling | 387.61 | 9.88 | 2209 | 271673 | 263733 | 62951407 |
Ill-defined disorder | 342.71 | 9.88 | 948 | 272934 | 80807 | 63134333 |
Toxicity to various agents | 332.03 | 9.88 | 346 | 273536 | 246904 | 62968236 |
Sleep disorder due to general medical condition, insomnia type | 330.79 | 9.88 | 710 | 273172 | 51507 | 63163633 |
Impaired healing | 319.10 | 9.88 | 1071 | 272811 | 101471 | 63113669 |
Gastrointestinal disorder | 309.45 | 9.88 | 1253 | 272629 | 129986 | 63085154 |
Pruritus | 278.89 | 9.88 | 2577 | 271305 | 358876 | 62856264 |
Ear pain | 278.60 | 9.88 | 533 | 273349 | 35585 | 63179555 |
Body temperature increased | 271.23 | 9.88 | 536 | 273346 | 36656 | 63178484 |
Weight increased | 268.50 | 9.88 | 1985 | 271897 | 258807 | 62956333 |
Stomatitis | 266.25 | 9.88 | 1245 | 272637 | 137480 | 63077660 |
Completed suicide | 263.95 | 9.88 | 150 | 273732 | 145523 | 63069617 |
Blister | 260.95 | 9.88 | 1181 | 272701 | 128633 | 63086507 |
Muscle spasticity | 243.52 | 9.88 | 379 | 273503 | 21415 | 63193725 |
Acute kidney injury | 209.74 | 9.88 | 521 | 273361 | 262894 | 62952246 |
Night sweats | 199.51 | 9.88 | 561 | 273321 | 48253 | 63166887 |
Respiratory disorder | 177.55 | 9.88 | 467 | 273415 | 38615 | 63176525 |
Blood pressure fluctuation | 170.71 | 9.88 | 513 | 273369 | 45804 | 63169336 |
Infusion related reaction | 170.52 | 9.88 | 1713 | 272169 | 243808 | 62971332 |
Joint swelling | 157.44 | 9.88 | 2129 | 271753 | 325537 | 62889603 |
Back pain | 157.34 | 9.88 | 1787 | 272095 | 262358 | 62952782 |
Blood pressure diastolic abnormal | 155.69 | 9.88 | 248 | 273634 | 14294 | 63200846 |
Fatigue | 155.54 | 9.88 | 4964 | 268918 | 883064 | 62332076 |
Contusion | 154.69 | 9.88 | 1143 | 272739 | 148901 | 63066239 |
Infection | 142.62 | 9.88 | 1564 | 272318 | 227609 | 62987531 |
Rheumatoid arthritis | 141.29 | 9.88 | 1695 | 272187 | 252124 | 62963016 |
Blood pressure increased | 140.38 | 9.88 | 1186 | 272696 | 160876 | 63054264 |
Insomnia | 136.70 | 9.88 | 1475 | 272407 | 213777 | 63001363 |
Blood pressure systolic increased | 133.38 | 9.88 | 479 | 273403 | 46918 | 63168222 |
Blood pressure systolic abnormal | 130.73 | 9.88 | 219 | 273663 | 13167 | 63201973 |
Urticaria | 129.43 | 9.88 | 1186 | 272696 | 164616 | 63050524 |
Pain | 115.30 | 9.88 | 4085 | 269797 | 736543 | 62478597 |
Bursitis | 115.21 | 9.88 | 387 | 273495 | 36654 | 63178486 |
Neutropenia | 112.29 | 9.88 | 383 | 273499 | 174622 | 63040518 |
Headache | 112.06 | 9.88 | 3546 | 270336 | 629695 | 62585445 |
Heart rate increased | 111.19 | 9.88 | 742 | 273140 | 93496 | 63121644 |
Cardiac failure | 110.45 | 9.88 | 133 | 273749 | 89009 | 63126131 |
Anaemia | 109.56 | 9.88 | 778 | 273104 | 292652 | 62922488 |
Hyponatraemia | 107.53 | 9.88 | 199 | 273683 | 111701 | 63103439 |
Temperature regulation disorder | 106.66 | 9.88 | 132 | 273750 | 6000 | 63209140 |
Therapeutic product effect decreased | 106.50 | 9.88 | 1288 | 272594 | 191899 | 63023241 |
Arthralgia | 104.36 | 9.88 | 3204 | 270678 | 566506 | 62648634 |
Electrocardiogram QT prolonged | 101.20 | 9.88 | 66 | 273816 | 59464 | 63155676 |
General physical health deterioration | 95.60 | 9.88 | 495 | 273387 | 200907 | 63014233 |
Hypersensitivity | 94.76 | 9.88 | 1781 | 272101 | 290904 | 62924236 |
Thrombocytopenia | 94.14 | 9.88 | 335 | 273547 | 150822 | 63064318 |
Device expulsion | 92.34 | 9.88 | 19 | 273863 | 34903 | 63180237 |
Food allergy | 91.30 | 9.88 | 171 | 273711 | 11230 | 63203910 |
Lactic acidosis | 91.13 | 9.88 | 26 | 273856 | 38261 | 63176879 |
Rhabdomyolysis | 87.40 | 9.88 | 40 | 273842 | 43911 | 63171229 |
Pancytopenia | 86.54 | 9.88 | 180 | 273702 | 96753 | 63118387 |
Hepatocellular injury | 85.97 | 9.88 | 9 | 273873 | 27372 | 63187768 |
Sopor | 82.24 | 9.88 | 3 | 273879 | 22161 | 63192979 |
Dyspnoea | 82.12 | 9.88 | 3560 | 270322 | 657753 | 62557387 |
Confusional state | 79.81 | 9.88 | 1448 | 272434 | 234932 | 62980208 |
Oxygen saturation decreased | 78.61 | 9.88 | 652 | 273230 | 87933 | 63127207 |
Leukopenia | 77.34 | 9.88 | 134 | 273748 | 77156 | 63137984 |
Drug reaction with eosinophilia and systemic symptoms | 76.88 | 9.88 | 25 | 273857 | 33811 | 63181329 |
Drug resistance | 76.13 | 9.88 | 6 | 273876 | 22927 | 63192213 |
Asthenia | 74.83 | 9.88 | 2175 | 271707 | 381429 | 62833711 |
Seizure | 74.16 | 9.88 | 307 | 273575 | 132327 | 63082813 |
Cholestasis | 73.83 | 9.88 | 18 | 273864 | 29416 | 63185724 |
Coma | 73.57 | 9.88 | 102 | 273780 | 64262 | 63150878 |
Cardiac arrest | 73.56 | 9.88 | 183 | 273699 | 92362 | 63122778 |
Toxic epidermal necrolysis | 73.05 | 9.88 | 11 | 273871 | 25323 | 63189817 |
Agranulocytosis | 72.27 | 9.88 | 11 | 273871 | 25123 | 63190017 |
Drug abuse | 71.41 | 9.88 | 127 | 273755 | 72391 | 63142749 |
Oropharyngeal pain | 69.22 | 9.88 | 667 | 273215 | 93820 | 63121320 |
Hypotension | 69.21 | 9.88 | 797 | 273085 | 271807 | 62943333 |
Hyperkalaemia | 69.14 | 9.88 | 79 | 273803 | 54124 | 63161016 |
Sleep disorder | 69.01 | 9.88 | 594 | 273288 | 80972 | 63134168 |
Maternal exposure during pregnancy | 68.85 | 9.88 | 612 | 273270 | 219450 | 62995690 |
Exposure during pregnancy | 68.44 | 9.88 | 392 | 273490 | 155155 | 63059985 |
Depressed level of consciousness | 68.36 | 9.88 | 101 | 273781 | 61977 | 63153163 |
Multiple organ dysfunction syndrome | 67.85 | 9.88 | 87 | 273795 | 56665 | 63158475 |
Epilepsy | 67.02 | 9.88 | 17 | 273865 | 27048 | 63188092 |
Myelosuppression | 66.74 | 9.88 | 11 | 273871 | 23692 | 63191448 |
Angioedema | 66.69 | 9.88 | 65 | 273817 | 47900 | 63167240 |
Bone marrow failure | 65.92 | 9.88 | 22 | 273860 | 29268 | 63185872 |
C-reactive protein increased | 65.77 | 9.88 | 200 | 273682 | 94507 | 63120633 |
Hypoglycaemia | 63.95 | 9.88 | 100 | 273782 | 59965 | 63155175 |
Osteonecrosis of jaw | 63.80 | 9.88 | 36 | 273846 | 35087 | 63180053 |
Pleural fibrosis | 62.42 | 9.88 | 76 | 273806 | 3396 | 63211744 |
Bronchial secretion retention | 62.14 | 9.88 | 68 | 273814 | 2705 | 63212435 |
Presbyacusis | 62.03 | 9.88 | 69 | 273813 | 2796 | 63212344 |
Hepatic function abnormal | 62.02 | 9.88 | 42 | 273840 | 37100 | 63178040 |
Blood pressure diastolic increased | 60.94 | 9.88 | 134 | 273748 | 9876 | 63205264 |
Mucosal inflammation | 60.29 | 9.88 | 68 | 273814 | 46860 | 63168280 |
Pleural thickening | 58.27 | 9.88 | 67 | 273815 | 2816 | 63212324 |
Metabolic acidosis | 58.24 | 9.88 | 65 | 273817 | 45004 | 63170136 |
Cardio-respiratory arrest | 58.14 | 9.88 | 106 | 273776 | 59853 | 63155287 |
Orthostatic hypotension | 57.60 | 9.88 | 43 | 273839 | 36117 | 63179023 |
Helicobacter infection | 57.50 | 9.88 | 633 | 273249 | 92152 | 63122988 |
Drug-induced liver injury | 56.51 | 9.88 | 54 | 273828 | 40168 | 63174972 |
Blood magnesium increased | 55.43 | 9.88 | 67 | 273815 | 2971 | 63212169 |
Coeliac disease | 54.16 | 9.88 | 149 | 273733 | 12648 | 63202492 |
Circulatory collapse | 53.90 | 9.88 | 14 | 273868 | 21924 | 63193216 |
Condition aggravated | 53.66 | 9.88 | 1323 | 272559 | 400894 | 62814246 |
Septic shock | 53.54 | 9.88 | 131 | 273751 | 66498 | 63148642 |
Hypocalcaemia | 52.76 | 9.88 | 36 | 273846 | 31677 | 63183463 |
Serotonin syndrome | 52.67 | 9.88 | 29 | 273853 | 28653 | 63186487 |
Malignant neoplasm progression | 52.44 | 9.88 | 180 | 273702 | 81941 | 63133199 |
Cytomegalovirus infection | 52.19 | 9.88 | 13 | 273869 | 20939 | 63194201 |
Illness | 51.78 | 9.88 | 376 | 273506 | 48683 | 63166457 |
Duodenal ulcer perforation | 51.33 | 9.88 | 589 | 273293 | 86620 | 63128520 |
Hypokalaemia | 50.99 | 9.88 | 252 | 273630 | 103552 | 63111588 |
Altered state of consciousness | 50.10 | 9.88 | 23 | 273859 | 25207 | 63189933 |
Suicide attempt | 49.55 | 9.88 | 119 | 273763 | 60799 | 63154341 |
Cough | 48.58 | 9.88 | 1628 | 272254 | 291115 | 62924025 |
Chest discomfort | 48.39 | 9.88 | 704 | 273178 | 109265 | 63105875 |
Renal failure | 47.80 | 9.88 | 304 | 273578 | 117348 | 63097792 |
Gamma-glutamyltransferase increased | 47.44 | 9.88 | 46 | 273836 | 33985 | 63181155 |
Abdominal pain upper | 47.41 | 9.88 | 1196 | 272686 | 205248 | 63009892 |
Swelling | 46.86 | 9.88 | 1536 | 272346 | 273842 | 62941298 |
Scoliosis | 46.23 | 9.88 | 104 | 273778 | 7784 | 63207356 |
Intentional self-injury | 45.70 | 9.88 | 27 | 273855 | 25660 | 63189480 |
Pyrexia | 45.42 | 9.88 | 2472 | 271410 | 468006 | 62747134 |
Drug ineffective | 45.15 | 9.88 | 3889 | 269993 | 1040876 | 62174264 |
Blood pressure diastolic decreased | 45.12 | 9.88 | 206 | 273676 | 22500 | 63192640 |
Sedation | 44.85 | 9.88 | 61 | 273821 | 38748 | 63176392 |
Rash maculo-papular | 44.60 | 9.88 | 43 | 273839 | 31853 | 63183287 |
Urine abnormality | 43.91 | 9.88 | 95 | 273787 | 6924 | 63208216 |
Bacterial disease carrier | 43.39 | 9.88 | 40 | 273842 | 1291 | 63213849 |
Abortion spontaneous | 42.65 | 9.88 | 87 | 273795 | 47108 | 63168032 |
Throat irritation | 42.33 | 9.88 | 293 | 273589 | 37354 | 63177786 |
Immunodeficiency | 41.93 | 9.88 | 186 | 273696 | 20068 | 63195072 |
Deafness neurosensory | 41.62 | 9.88 | 75 | 273807 | 4780 | 63210360 |
Sinus disorder | 41.05 | 9.88 | 212 | 273670 | 24341 | 63190799 |
Skin necrosis | 40.35 | 9.88 | 6 | 273876 | 13944 | 63201196 |
Pancreatitis acute | 39.91 | 9.88 | 35 | 273847 | 27131 | 63188009 |
Febrile neutropenia | 39.89 | 9.88 | 323 | 273559 | 118126 | 63097014 |
Generalised tonic-clonic seizure | 39.55 | 9.88 | 40 | 273842 | 28976 | 63186164 |
Epigastric discomfort | 39.30 | 9.88 | 89 | 273793 | 6691 | 63208449 |
Injection site pain | 39.24 | 9.88 | 364 | 273518 | 129436 | 63085704 |
Rash | 39.24 | 9.88 | 2866 | 271016 | 558005 | 62657135 |
Syncope | 39.12 | 9.88 | 321 | 273561 | 117064 | 63098076 |
Lip dry | 39.05 | 9.88 | 151 | 273731 | 15319 | 63199821 |
Neovascularisation | 38.48 | 9.88 | 35 | 273847 | 1110 | 63214030 |
Flushing | 38.46 | 9.88 | 494 | 273388 | 74593 | 63140547 |
Foetal exposure during pregnancy | 38.20 | 9.88 | 49 | 273833 | 31913 | 63183227 |
Influenza | 38.04 | 9.88 | 670 | 273212 | 108052 | 63107088 |
Osteonecrosis | 38.01 | 9.88 | 30 | 273852 | 24500 | 63190640 |
Panniculitis | 37.73 | 9.88 | 3 | 273879 | 11382 | 63203758 |
Heart rate decreased | 37.59 | 9.88 | 330 | 273552 | 45230 | 63169910 |
Asthma | 37.39 | 9.88 | 765 | 273117 | 126796 | 63088344 |
Myoclonus | 37.35 | 9.88 | 11 | 273871 | 15857 | 63199283 |
Poisoning deliberate | 37.05 | 9.88 | 3 | 273879 | 11215 | 63203925 |
Melaena | 36.87 | 9.88 | 46 | 273836 | 30319 | 63184821 |
Rhinorrhoea | 36.85 | 9.88 | 439 | 273443 | 65138 | 63150002 |
Rheumatoid factor positive | 36.42 | 9.88 | 214 | 273668 | 84192 | 63130948 |
Alanine aminotransferase increased | 36.32 | 9.88 | 280 | 273602 | 103490 | 63111650 |
Sedation complication | 35.56 | 9.88 | 8 | 273874 | 13814 | 63201326 |
Dyskinesia | 35.29 | 9.88 | 52 | 273830 | 31950 | 63183190 |
Bradycardia | 35.25 | 9.88 | 179 | 273703 | 73048 | 63142092 |
Upper respiratory tract infection | 34.81 | 9.88 | 522 | 273360 | 81525 | 63133615 |
Renal impairment | 34.51 | 9.88 | 231 | 273651 | 88124 | 63127016 |
Lymphopenia | 34.43 | 9.88 | 18 | 273864 | 18309 | 63196831 |
Urine leukocyte esterase positive | 34.21 | 9.88 | 58 | 273824 | 3521 | 63211619 |
Hepatotoxicity | 33.71 | 9.88 | 68 | 273814 | 36973 | 63178167 |
Bone cyst | 33.67 | 9.88 | 45 | 273837 | 2209 | 63212931 |
Nasal congestion | 33.64 | 9.88 | 432 | 273450 | 65228 | 63149912 |
Aspartate aminotransferase increased | 33.30 | 9.88 | 240 | 273642 | 90037 | 63125103 |
Peptic ulcer haemorrhage | 32.71 | 9.88 | 31 | 273851 | 1037 | 63214103 |
Lower limb fracture | 32.43 | 9.88 | 197 | 273685 | 24024 | 63191116 |
Injection site erythema | 32.21 | 9.88 | 218 | 273664 | 82956 | 63132184 |
Creatinine renal clearance decreased | 32.17 | 9.88 | 15 | 273867 | 16293 | 63198847 |
Torsade de pointes | 31.89 | 9.88 | 9 | 273873 | 13342 | 63201798 |
Overdose | 31.73 | 9.88 | 330 | 273552 | 114748 | 63100392 |
Anxiety | 31.65 | 9.88 | 1192 | 272690 | 216349 | 62998791 |
Osteoarthritis | 31.05 | 9.88 | 581 | 273301 | 94762 | 63120378 |
Hypothermia | 30.91 | 9.88 | 10 | 273872 | 13571 | 63201569 |
Weight fluctuation | 30.89 | 9.88 | 103 | 273779 | 9716 | 63205424 |
Accidental exposure to product | 30.74 | 9.88 | 44 | 273838 | 27361 | 63187779 |
Labelled drug-drug interaction medication error | 30.26 | 9.88 | 10 | 273872 | 13389 | 63201751 |
Premature baby | 30.11 | 9.88 | 27 | 273855 | 20708 | 63194432 |
Nephropathy toxic | 30.06 | 9.88 | 3 | 273879 | 9476 | 63205664 |
Interstitial lung disease | 29.99 | 9.88 | 151 | 273731 | 61757 | 63153383 |
Product tampering | 29.93 | 9.88 | 20 | 273862 | 398 | 63214742 |
Premature delivery | 29.83 | 9.88 | 53 | 273829 | 30228 | 63184912 |
Disorientation | 29.81 | 9.88 | 80 | 273802 | 39372 | 63175768 |
Facet joint syndrome | 29.44 | 9.88 | 117 | 273765 | 12021 | 63203119 |
Inappropriate antidiuretic hormone secretion | 29.32 | 9.88 | 15 | 273867 | 15447 | 63199693 |
Shock haemorrhagic | 29.22 | 9.88 | 4 | 273878 | 9891 | 63205249 |
Wrong technique in product usage process | 29.10 | 9.88 | 154 | 273728 | 62186 | 63152954 |
Red blood cells urine positive | 29.01 | 9.88 | 50 | 273832 | 3076 | 63212064 |
COVID-19 | 28.89 | 9.88 | 665 | 273217 | 112438 | 63102702 |
Agitation | 28.80 | 9.88 | 146 | 273736 | 59611 | 63155529 |
Chills | 28.77 | 9.88 | 666 | 273216 | 112712 | 63102428 |
Product prescribing error | 28.72 | 9.88 | 43 | 273839 | 26246 | 63188894 |
Drug eruption | 28.47 | 9.88 | 50 | 273832 | 28644 | 63186496 |
Transplant rejection | 28.22 | 9.88 | 6 | 273876 | 10774 | 63204366 |
Poisoning | 27.97 | 9.88 | 12 | 273870 | 13688 | 63201452 |
Osteopenia | 27.82 | 9.88 | 163 | 273719 | 19622 | 63195518 |
Fluid retention | 27.80 | 9.88 | 386 | 273496 | 59300 | 63155840 |
Systemic lupus erythematosus | 27.58 | 9.88 | 688 | 273194 | 208230 | 63006910 |
Drug tolerance decreased | 27.54 | 9.88 | 21 | 273861 | 17452 | 63197688 |
Sinus operation | 27.54 | 9.88 | 44 | 273838 | 2542 | 63212598 |
Intentional overdose | 27.41 | 9.88 | 197 | 273685 | 73955 | 63141185 |
Colitis microscopic | 27.05 | 9.88 | 4 | 273878 | 9335 | 63205805 |
Parkinsonism | 26.94 | 9.88 | 6 | 273876 | 10433 | 63204707 |
Ejection fraction decreased | 26.93 | 9.88 | 34 | 273848 | 22298 | 63192842 |
Neutropenic sepsis | 26.89 | 9.88 | 19 | 273863 | 16419 | 63198721 |
Peripheral venous disease | 26.83 | 9.88 | 135 | 273747 | 15342 | 63199798 |
Blood creatine phosphokinase increased | 26.73 | 9.88 | 57 | 273825 | 30373 | 63184767 |
Therapeutic response decreased | 26.53 | 9.88 | 156 | 273726 | 61369 | 63153771 |
Haemodynamic instability | 26.47 | 9.88 | 4 | 273878 | 9186 | 63205954 |
Pemphigus | 26.47 | 9.88 | 597 | 273285 | 183129 | 63032011 |
Deep vein thrombosis postoperative | 26.31 | 9.88 | 108 | 273774 | 11261 | 63203879 |
Stevens-Johnson syndrome | 26.12 | 9.88 | 42 | 273840 | 24908 | 63190232 |
Haematoma | 26.02 | 9.88 | 71 | 273811 | 34749 | 63180391 |
Posterior reversible encephalopathy syndrome | 25.90 | 9.88 | 22 | 273860 | 17323 | 63197817 |
Product substitution issue | 25.50 | 9.88 | 19 | 273863 | 15977 | 63199163 |
Thrombotic microangiopathy | 25.45 | 9.88 | 7 | 273875 | 10554 | 63204586 |
Psychotic disorder | 25.33 | 9.88 | 45 | 273837 | 25667 | 63189473 |
Rheumatoid nodule | 25.32 | 9.88 | 22 | 273860 | 17133 | 63198007 |
Respiratory depression | 24.99 | 9.88 | 14 | 273868 | 13701 | 63201439 |
Macular degeneration | 24.62 | 9.88 | 42 | 273840 | 24334 | 63190806 |
Superinfection | 24.59 | 9.88 | 42 | 273840 | 2565 | 63212575 |
Device dislocation | 24.42 | 9.88 | 46 | 273836 | 25659 | 63189481 |
Lupus vasculitis | 24.41 | 9.88 | 20 | 273862 | 549 | 63214591 |
Status epilepticus | 24.41 | 9.88 | 18 | 273864 | 15215 | 63199925 |
Productive cough | 24.09 | 9.88 | 395 | 273487 | 62813 | 63152327 |
Sinus congestion | 24.01 | 9.88 | 147 | 273735 | 17976 | 63197164 |
Constipation | 23.87 | 9.88 | 1193 | 272689 | 223750 | 62991390 |
Injection site reaction | 23.87 | 9.88 | 151 | 273731 | 58373 | 63156767 |
Cestode infection | 23.66 | 9.88 | 15 | 273867 | 272 | 63214868 |
Granuloma skin | 23.57 | 9.88 | 4 | 273878 | 8433 | 63206707 |
Pneumocystis jirovecii pneumonia | 23.42 | 9.88 | 23 | 273859 | 16891 | 63198249 |
Jaundice | 23.11 | 9.88 | 58 | 273824 | 29193 | 63185947 |
Spinal meningioma benign | 23.05 | 9.88 | 11 | 273871 | 110 | 63215030 |
Alopecia | 22.94 | 9.88 | 1206 | 272676 | 336330 | 62878810 |
Haematemesis | 22.73 | 9.88 | 62 | 273820 | 30350 | 63184790 |
Hyperglycaemia | 22.71 | 9.88 | 98 | 273784 | 41769 | 63173371 |
Adulterated product | 22.56 | 9.88 | 14 | 273868 | 244 | 63214896 |
Suicidal ideation | 22.51 | 9.88 | 167 | 273715 | 62254 | 63152886 |
Neurotoxicity | 22.50 | 9.88 | 24 | 273858 | 16966 | 63198174 |
Hypercalcaemia | 22.50 | 9.88 | 56 | 273826 | 28266 | 63186874 |
Acute respiratory distress syndrome | 22.46 | 9.88 | 42 | 273840 | 23492 | 63191648 |
Polyneuropathy | 22.41 | 9.88 | 18 | 273864 | 14571 | 63200569 |
Hepatic enzyme increased | 22.29 | 9.88 | 1077 | 272805 | 201251 | 63013889 |
Haemophagocytic lymphohistiocytosis | 22.19 | 9.88 | 9 | 273873 | 10618 | 63204522 |
Disease progression | 22.18 | 9.88 | 384 | 273498 | 122374 | 63092766 |
Akathisia | 22.16 | 9.88 | 6 | 273876 | 9140 | 63206000 |
Treatment failure | 22.00 | 9.88 | 672 | 273210 | 198371 | 63016769 |
Oliguria | 21.99 | 9.88 | 6 | 273876 | 9095 | 63206045 |
Cerebral haemorrhage | 21.97 | 9.88 | 64 | 273818 | 30665 | 63184475 |
Ear pruritus | 21.82 | 9.88 | 51 | 273831 | 3914 | 63211226 |
Seasonal allergy | 21.78 | 9.88 | 160 | 273722 | 20790 | 63194350 |
Cyst | 21.70 | 9.88 | 119 | 273763 | 13980 | 63201160 |
Magnesium deficiency | 21.69 | 9.88 | 19 | 273863 | 573 | 63214567 |
Cerebral infarction | 21.62 | 9.88 | 44 | 273838 | 23849 | 63191291 |
Feeling hot | 21.60 | 9.88 | 321 | 273561 | 50033 | 63165107 |
Schizophrenia | 21.49 | 9.88 | 8 | 273874 | 9944 | 63205196 |
Tubulointerstitial nephritis | 21.31 | 9.88 | 33 | 273849 | 19870 | 63195270 |
Diabetic ketoacidosis | 21.01 | 9.88 | 35 | 273847 | 20470 | 63194670 |
Pain in extremity | 20.96 | 9.88 | 1681 | 272201 | 329805 | 62885335 |
Hepatic failure | 20.88 | 9.88 | 81 | 273801 | 35575 | 63179565 |
Acute generalised exanthematous pustulosis | 20.70 | 9.88 | 11 | 273871 | 11088 | 63204052 |
Mydriasis | 20.66 | 9.88 | 13 | 273869 | 11943 | 63203197 |
Red cell distribution width increased | 20.55 | 9.88 | 95 | 273787 | 10429 | 63204711 |
Breast cancer female | 20.49 | 9.88 | 17 | 273865 | 13542 | 63201598 |
Bronchopulmonary aspergillosis | 20.30 | 9.88 | 6 | 273876 | 8629 | 63206511 |
Infusion site extravasation | 20.27 | 9.88 | 94 | 273788 | 10332 | 63204808 |
Disseminated intravascular coagulation | 20.01 | 9.88 | 32 | 273850 | 19019 | 63196121 |
White blood cells urine positive | 19.82 | 9.88 | 58 | 273824 | 5100 | 63210040 |
Cognitive disorder | 19.81 | 9.88 | 150 | 273732 | 55665 | 63159475 |
Peritonitis | 19.78 | 9.88 | 27 | 273855 | 17127 | 63198013 |
Jaundice cholestatic | 19.33 | 9.88 | 4 | 273878 | 7320 | 63207820 |
Injection site swelling | 19.27 | 9.88 | 123 | 273759 | 47449 | 63167691 |
Drug withdrawal syndrome | 19.18 | 9.88 | 57 | 273825 | 27137 | 63188003 |
Dry mouth | 19.02 | 9.88 | 455 | 273427 | 77408 | 63137732 |
Glossodynia | 18.78 | 9.88 | 608 | 273274 | 178268 | 63036872 |
Ventricular tachycardia | 18.76 | 9.88 | 36 | 273846 | 19943 | 63195197 |
Hepatitis | 18.73 | 9.88 | 98 | 273784 | 39690 | 63175450 |
Aplastic anaemia | 18.57 | 9.88 | 9 | 273873 | 9560 | 63205580 |
Sudden death | 18.56 | 9.88 | 11 | 273871 | 10438 | 63204702 |
Face oedema | 18.48 | 9.88 | 37 | 273845 | 20175 | 63194965 |
Neuroleptic malignant syndrome | 18.36 | 9.88 | 15 | 273867 | 12041 | 63203099 |
SARS-CoV-2 test positive | 18.22 | 9.88 | 76 | 273806 | 7980 | 63207160 |
Foetal growth restriction | 18.21 | 9.88 | 5 | 273877 | 7548 | 63207592 |
Left ventricular dysfunction | 18.15 | 9.88 | 15 | 273867 | 11973 | 63203167 |
Dermatitis bullous | 18.11 | 9.88 | 7 | 273875 | 8501 | 63206639 |
Diarrhoea | 17.87 | 9.88 | 3422 | 270460 | 711944 | 62503196 |
Claustrophobia | 17.84 | 9.88 | 22 | 273860 | 996 | 63214144 |
Off label use | 17.83 | 9.88 | 2595 | 271287 | 671867 | 62543273 |
Dystonia | 17.77 | 9.88 | 20 | 273862 | 13799 | 63201341 |
Autoimmune disorder | 17.75 | 9.88 | 131 | 273751 | 17046 | 63198094 |
Ascites | 17.70 | 9.88 | 103 | 273779 | 40625 | 63174515 |
Hypomagnesaemia | 17.66 | 9.88 | 64 | 273818 | 28673 | 63186467 |
Miosis | 17.48 | 9.88 | 5 | 273877 | 7348 | 63207792 |
Genital haemorrhage | 17.41 | 9.88 | 5 | 273877 | 7327 | 63207813 |
Vein collapse | 17.40 | 9.88 | 22 | 273860 | 1022 | 63214118 |
Abnormal behaviour | 17.31 | 9.88 | 42 | 273840 | 21384 | 63193756 |
Rib fracture | 17.27 | 9.88 | 161 | 273721 | 22436 | 63192704 |
Blood bilirubin increased | 17.19 | 9.88 | 92 | 273790 | 37048 | 63178092 |
Ischaemic stroke | 17.18 | 9.88 | 32 | 273850 | 17925 | 63197215 |
Hallucination, auditory | 17.11 | 9.88 | 18 | 273864 | 12806 | 63202334 |
Rash erythematous | 17.08 | 9.88 | 268 | 273614 | 42242 | 63172898 |
Infusion site pain | 17.06 | 9.88 | 128 | 273754 | 16741 | 63198399 |
Femur fracture | 16.89 | 9.88 | 108 | 273774 | 41648 | 63173492 |
Proteinuria | 16.70 | 9.88 | 36 | 273846 | 19109 | 63196031 |
Aspergillus infection | 16.67 | 9.88 | 7 | 273875 | 8086 | 63207054 |
Sneezing | 16.64 | 9.88 | 135 | 273747 | 18083 | 63197057 |
Femoral neck fracture | 16.57 | 9.88 | 8 | 273874 | 8515 | 63206625 |
Epstein-Barr virus infection | 16.52 | 9.88 | 7 | 273875 | 8043 | 63207097 |
Vital capacity decreased | 16.51 | 9.88 | 28 | 273854 | 1700 | 63213440 |
Large intestine perforation | 16.43 | 9.88 | 8 | 273874 | 8474 | 63206666 |
Urinary sediment present | 16.36 | 9.88 | 32 | 273850 | 2171 | 63212969 |
Cardiogenic shock | 16.25 | 9.88 | 33 | 273849 | 17899 | 63197241 |
Respiratory tract congestion | 16.21 | 9.88 | 132 | 273750 | 17700 | 63197440 |
Blood calcium decreased | 16.20 | 9.88 | 59 | 273823 | 26392 | 63188748 |
Muscle spasms | 16.11 | 9.88 | 826 | 273056 | 155324 | 63059816 |
Therapeutic response shortened | 16.11 | 9.88 | 97 | 273785 | 11791 | 63203349 |
Transaminases increased | 16.06 | 9.88 | 75 | 273807 | 31292 | 63183848 |
Sputum discoloured | 15.95 | 9.88 | 123 | 273759 | 16224 | 63198916 |
Pathogen resistance | 15.88 | 9.88 | 4 | 273878 | 6394 | 63208746 |
Weight decreased | 15.79 | 9.88 | 1393 | 272489 | 275405 | 62939735 |
Drug level increased | 15.78 | 9.88 | 48 | 273834 | 22688 | 63192452 |
Oligohydramnios | 15.76 | 9.88 | 4 | 273878 | 6362 | 63208778 |
Arteriovenous fistula occlusion | 15.59 | 9.88 | 13 | 273869 | 366 | 63214774 |
Chronic obstructive pulmonary disease | 15.51 | 9.88 | 367 | 273515 | 62319 | 63152821 |
Sputum culture positive | 15.51 | 9.88 | 31 | 273851 | 2136 | 63213004 |
Muscle rigidity | 15.51 | 9.88 | 16 | 273866 | 11484 | 63203656 |
Stress cardiomyopathy | 15.36 | 9.88 | 11 | 273871 | 9439 | 63205701 |
Graft versus host disease | 15.36 | 9.88 | 5 | 273877 | 6758 | 63208382 |
Osteosclerosis | 15.21 | 9.88 | 44 | 273838 | 3844 | 63211296 |
Menstruation delayed | 15.19 | 9.88 | 27 | 273855 | 1702 | 63213438 |
Injection site pruritus | 15.19 | 9.88 | 123 | 273759 | 44993 | 63170147 |
Purpura | 15.17 | 9.88 | 16 | 273866 | 11369 | 63203771 |
Haemodialysis | 15.09 | 9.88 | 10 | 273872 | 8937 | 63206203 |
Product use issue | 14.94 | 9.88 | 788 | 273094 | 219732 | 62995408 |
Hypothyroidism | 14.92 | 9.88 | 115 | 273767 | 42517 | 63172623 |
Type 2 diabetes mellitus | 14.92 | 9.88 | 190 | 273692 | 63678 | 63151462 |
Pulmonary embolism | 14.91 | 9.88 | 386 | 273496 | 116298 | 63098842 |
Concussion | 14.89 | 9.88 | 79 | 273803 | 9165 | 63205975 |
Exposure to toxic agent | 14.85 | 9.88 | 3 | 273879 | 5584 | 63209556 |
Sputum culture | 14.72 | 9.88 | 11 | 273871 | 263 | 63214877 |
Injection site warmth | 14.60 | 9.88 | 27 | 273855 | 15168 | 63199972 |
Swollen tongue | 14.60 | 9.88 | 89 | 273793 | 34711 | 63180429 |
Eye infection viral | 14.55 | 9.88 | 9 | 273873 | 156 | 63214984 |
Dry eye | 14.54 | 9.88 | 252 | 273630 | 40509 | 63174631 |
Specific gravity urine increased | 14.50 | 9.88 | 10 | 273872 | 210 | 63214930 |
Libido increased | 14.48 | 9.88 | 23 | 273859 | 1322 | 63213818 |
Migraine | 14.46 | 9.88 | 564 | 273318 | 102782 | 63112358 |
Bradyphrenia | 14.43 | 9.88 | 6 | 273876 | 6974 | 63208166 |
Ventricular fibrillation | 14.38 | 9.88 | 18 | 273864 | 11849 | 63203291 |
Body temperature fluctuation | 14.38 | 9.88 | 31 | 273851 | 2254 | 63212886 |
Acute myeloid leukaemia | 14.34 | 9.88 | 33 | 273849 | 17114 | 63198026 |
Enteritis | 14.33 | 9.88 | 9 | 273873 | 8277 | 63206863 |
Corneal epithelium defect | 14.33 | 9.88 | 12 | 273870 | 340 | 63214800 |
Urogenital prolapse | 14.29 | 9.88 | 5 | 273877 | 20 | 63215120 |
Lip pruritus | 14.29 | 9.88 | 19 | 273863 | 928 | 63214212 |
Cardiovascular disorder | 14.23 | 9.88 | 18 | 273864 | 11794 | 63203346 |
Myelodysplastic syndrome | 14.21 | 9.88 | 32 | 273850 | 16722 | 63198418 |
Skin ulcer | 14.20 | 9.88 | 118 | 273764 | 42927 | 63172213 |
Hyperthyroidism | 14.17 | 9.88 | 26 | 273856 | 14647 | 63200493 |
Enthesopathy | 14.03 | 9.88 | 10 | 273872 | 8604 | 63206536 |
Reversible airways obstruction | 13.97 | 9.88 | 27 | 273855 | 1815 | 63213325 |
Hallucination, visual | 13.93 | 9.88 | 40 | 273842 | 19258 | 63195882 |
Bacterial test | 13.93 | 9.88 | 21 | 273861 | 1153 | 63213987 |
Injection site haematoma | 13.92 | 9.88 | 6 | 273876 | 6826 | 63208314 |
Tooth disorder | 13.89 | 9.88 | 184 | 273698 | 27973 | 63187167 |
Infusion site erythema | 13.78 | 9.88 | 92 | 273790 | 11587 | 63203553 |
International normalised ratio increased | 13.67 | 9.88 | 131 | 273751 | 46294 | 63168846 |
Metastases to liver | 13.65 | 9.88 | 54 | 273828 | 23585 | 63191555 |
Stillbirth | 13.64 | 9.88 | 6 | 273876 | 6744 | 63208396 |
Cushingoid | 13.63 | 9.88 | 10 | 273872 | 8475 | 63206665 |
Soft tissue injury | 13.50 | 9.88 | 25 | 273857 | 1627 | 63213513 |
Loss of consciousness | 13.49 | 9.88 | 397 | 273485 | 117724 | 63097416 |
Pyelonephritis | 13.47 | 9.88 | 36 | 273846 | 17742 | 63197398 |
Lichen sclerosus | 13.39 | 9.88 | 20 | 273862 | 1089 | 63214051 |
Premenstrual syndrome | 13.35 | 9.88 | 16 | 273866 | 703 | 63214437 |
Shock | 13.29 | 9.88 | 54 | 273828 | 23409 | 63191731 |
Second primary malignancy | 13.27 | 9.88 | 9 | 273873 | 7944 | 63207196 |
Oedema peripheral | 13.25 | 9.88 | 675 | 273207 | 188836 | 63026304 |
Dysarthria | 13.23 | 9.88 | 119 | 273763 | 42592 | 63172548 |
Hyperthermia | 13.20 | 9.88 | 12 | 273870 | 9144 | 63205996 |
Limb injury | 13.20 | 9.88 | 168 | 273714 | 25309 | 63189831 |
Hypoalbuminaemia | 13.19 | 9.88 | 19 | 273863 | 11786 | 63203354 |
Hepatitis acute | 13.10 | 9.88 | 12 | 273870 | 9108 | 63206032 |
Unintentional medical device removal | 13.06 | 9.88 | 5 | 273877 | 6110 | 63209030 |
Neuralgia | 13.03 | 9.88 | 170 | 273712 | 25756 | 63189384 |
Multiple allergies | 13.00 | 9.88 | 103 | 273779 | 13699 | 63201441 |
No adverse event | 12.99 | 9.88 | 115 | 273767 | 41290 | 63173850 |
Creatinine urine decreased | 12.97 | 9.88 | 9 | 273873 | 191 | 63214949 |
Device malfunction | 12.90 | 9.88 | 37 | 273845 | 17820 | 63197320 |
Post-traumatic neck syndrome | 12.89 | 9.88 | 28 | 273854 | 2046 | 63213094 |
Muscle strain | 12.84 | 9.88 | 70 | 273812 | 8204 | 63206936 |
Tenosynovitis | 12.83 | 9.88 | 25 | 273857 | 13770 | 63201370 |
Blue toe syndrome | 12.82 | 9.88 | 12 | 273870 | 395 | 63214745 |
Eczema | 12.82 | 9.88 | 84 | 273798 | 32207 | 63182933 |
Mite allergy | 12.77 | 9.88 | 15 | 273867 | 645 | 63214495 |
Musculoskeletal pain | 12.77 | 9.88 | 503 | 273379 | 91774 | 63123366 |
Breast cancer stage I | 12.60 | 9.88 | 7 | 273875 | 6882 | 63208258 |
Rheumatic fever | 12.55 | 9.88 | 122 | 273760 | 42989 | 63172151 |
Device related infection | 12.53 | 9.88 | 55 | 273827 | 23337 | 63191803 |
Liver function test abnormal | 12.53 | 9.88 | 140 | 273742 | 48041 | 63167099 |
Staphylococcal sepsis | 12.52 | 9.88 | 10 | 273872 | 8118 | 63207022 |
Respiratory failure | 12.48 | 9.88 | 339 | 273543 | 101519 | 63113621 |
Blood urea increased | 12.40 | 9.88 | 65 | 273817 | 26314 | 63188826 |
Blood urine present | 12.35 | 9.88 | 109 | 273773 | 14960 | 63200180 |
Stress | 12.27 | 9.88 | 378 | 273504 | 66789 | 63148351 |
Body height decreased | 12.27 | 9.88 | 80 | 273802 | 9998 | 63205142 |
Pancreatitis | 12.19 | 9.88 | 144 | 273738 | 48911 | 63166229 |
Hypercholesterolaemia | 12.15 | 9.88 | 49 | 273833 | 21285 | 63193855 |
Atelectasis | 12.14 | 9.88 | 144 | 273738 | 21339 | 63193801 |
Live birth | 12.13 | 9.88 | 63 | 273819 | 25567 | 63189573 |
Limb mass | 12.09 | 9.88 | 36 | 273846 | 3196 | 63211944 |
C-reactive protein abnormal | 12.06 | 9.88 | 272 | 273610 | 45824 | 63169316 |
Nervous system disorder | 12.06 | 9.88 | 41 | 273841 | 18725 | 63196415 |
Faecaloma | 11.94 | 9.88 | 10 | 273872 | 7931 | 63207209 |
Ulcer | 11.90 | 9.88 | 65 | 273817 | 26042 | 63189098 |
Culture urine positive | 11.89 | 9.88 | 39 | 273843 | 3648 | 63211492 |
Hyperbilirubinaemia | 11.88 | 9.88 | 19 | 273863 | 11295 | 63203845 |
Mania | 11.86 | 9.88 | 22 | 273860 | 12345 | 63202795 |
Device use error | 11.84 | 9.88 | 5 | 273877 | 5756 | 63209384 |
Caesarean section | 11.79 | 9.88 | 36 | 273846 | 16996 | 63198144 |
Ileus | 11.79 | 9.88 | 29 | 273853 | 14696 | 63200444 |
Asphyxia | 11.72 | 9.88 | 6 | 273876 | 6175 | 63208965 |
Peripheral sensory neuropathy | 11.69 | 9.88 | 9 | 273873 | 7442 | 63207698 |
Hyperammonaemia | 11.65 | 9.88 | 4 | 273878 | 5228 | 63209912 |
Skin toxicity | 11.60 | 9.88 | 3 | 273879 | 4711 | 63210429 |
Nerve compression | 11.59 | 9.88 | 73 | 273809 | 9014 | 63206126 |
Full blood count decreased | 11.59 | 9.88 | 167 | 273715 | 25857 | 63189283 |
Pulse abnormal | 11.51 | 9.88 | 29 | 273853 | 2335 | 63212805 |
Electrolyte imbalance | 11.50 | 9.88 | 46 | 273836 | 20030 | 63195110 |
Cataract | 11.48 | 9.88 | 325 | 273557 | 56728 | 63158412 |
Endometrial disorder | 11.42 | 9.88 | 15 | 273867 | 724 | 63214416 |
Red blood cell sedimentation rate increased | 11.36 | 9.88 | 128 | 273754 | 43854 | 63171286 |
Platelet count decreased | 11.18 | 9.88 | 399 | 273483 | 115723 | 63099417 |
Blood alkaline phosphatase increased | 11.12 | 9.88 | 125 | 273757 | 42842 | 63172298 |
Salivary hypersecretion | 11.11 | 9.88 | 10 | 273872 | 7656 | 63207484 |
Nonspecific reaction | 11.04 | 9.88 | 28 | 273854 | 2264 | 63212876 |
Gait inability | 11.03 | 9.88 | 303 | 273579 | 52656 | 63162484 |
Nephrogenic systemic fibrosis | 11.02 | 9.88 | 3 | 273879 | 4553 | 63210587 |
Human papilloma virus test positive | 11.02 | 9.88 | 13 | 273869 | 562 | 63214578 |
Finger deformity | 11.01 | 9.88 | 64 | 273818 | 7681 | 63207459 |
Haematuria | 11.00 | 9.88 | 77 | 273805 | 29080 | 63186060 |
Sepsis | 10.97 | 9.88 | 544 | 273338 | 152579 | 63062561 |
Adrenal insufficiency | 10.94 | 9.88 | 40 | 273842 | 17875 | 63197265 |
Swollen joint count increased | 10.93 | 9.88 | 101 | 273781 | 35953 | 63179187 |
Obstruction | 10.92 | 9.88 | 34 | 273848 | 3093 | 63212047 |
Rebound effect | 10.91 | 9.88 | 3 | 273879 | 4523 | 63210617 |
Necrosis | 10.90 | 9.88 | 5 | 273877 | 5482 | 63209658 |
Blood creatinine increased | 10.85 | 9.88 | 292 | 273590 | 87552 | 63127588 |
Mobility decreased | 10.84 | 9.88 | 420 | 273462 | 120739 | 63094401 |
Flail chest | 10.82 | 9.88 | 6 | 273876 | 84 | 63215056 |
Progressive multifocal leukoencephalopathy | 10.82 | 9.88 | 25 | 273857 | 12946 | 63202194 |
Dermatitis exfoliative | 10.80 | 9.88 | 5 | 273877 | 5454 | 63209686 |
Feeling abnormal | 10.78 | 9.88 | 761 | 273121 | 147631 | 63067509 |
Lower respiratory tract congestion | 10.66 | 9.88 | 32 | 273850 | 2854 | 63212286 |
Palmar-plantar erythrodysaesthesia syndrome | 10.66 | 9.88 | 57 | 273825 | 22958 | 63192182 |
Upper-airway cough syndrome | 10.64 | 9.88 | 85 | 273797 | 11333 | 63203807 |
Acute graft versus host disease | 10.55 | 9.88 | 3 | 273879 | 4425 | 63210715 |
Gastrointestinal haemorrhage | 10.51 | 9.88 | 268 | 273614 | 80908 | 63134232 |
Hepatic cirrhosis | 10.51 | 9.88 | 63 | 273819 | 24671 | 63190469 |
Urine ketone body present | 10.45 | 9.88 | 29 | 273853 | 2474 | 63212666 |
Device difficult to use | 10.40 | 9.88 | 25 | 273857 | 12771 | 63202369 |
Bronchitis | 10.38 | 9.88 | 648 | 273234 | 124287 | 63090853 |
Hypertransaminasaemia | 10.34 | 9.88 | 8 | 273874 | 6601 | 63208539 |
Metastases to central nervous system | 10.34 | 9.88 | 26 | 273856 | 13079 | 63202061 |
Lung perforation | 10.34 | 9.88 | 6 | 273876 | 92 | 63215048 |
Sternal fracture | 10.30 | 9.88 | 27 | 273855 | 2227 | 63212913 |
Blood lactate dehydrogenase increased | 10.29 | 9.88 | 58 | 273824 | 23058 | 63192082 |
Metastases to lung | 10.29 | 9.88 | 25 | 273857 | 12725 | 63202415 |
Toxic encephalopathy | 10.25 | 9.88 | 8 | 273874 | 6571 | 63208569 |
C-reactive protein | 10.23 | 9.88 | 45 | 273837 | 4837 | 63210303 |
Personality change | 10.22 | 9.88 | 9 | 273873 | 6964 | 63208176 |
Hostility | 10.22 | 9.88 | 24 | 273858 | 1848 | 63213292 |
Encephalitis | 10.22 | 9.88 | 14 | 273868 | 8866 | 63206274 |
Aphasia | 10.20 | 9.88 | 92 | 273790 | 32908 | 63182232 |
Tardive dyskinesia | 10.19 | 9.88 | 13 | 273869 | 8489 | 63206651 |
Poor quality sleep | 10.14 | 9.88 | 131 | 273751 | 19804 | 63195336 |
Hyperadrenalism | 10.12 | 9.88 | 4 | 273878 | 24 | 63215116 |
Respiratory arrest | 10.09 | 9.88 | 91 | 273791 | 32554 | 63182586 |
Paradoxical drug reaction | 10.05 | 9.88 | 40 | 273842 | 4112 | 63211028 |
Basal cell carcinoma | 10.04 | 9.88 | 75 | 273807 | 27916 | 63187224 |
Hepatic encephalopathy | 10.02 | 9.88 | 21 | 273861 | 11261 | 63203879 |
Rectal haemorrhage | 9.97 | 9.88 | 150 | 273732 | 48880 | 63166260 |
Head discomfort | 9.96 | 9.88 | 95 | 273787 | 13320 | 63201820 |
Cytomegalovirus viraemia | 9.96 | 9.88 | 6 | 273876 | 5643 | 63209497 |
Product use in unapproved indication | 9.96 | 9.88 | 652 | 273230 | 178428 | 63036712 |
Anterior chamber cell | 9.93 | 9.88 | 12 | 273870 | 532 | 63214608 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Infusion related reaction | 304.71 | 10.59 | 538 | 97082 | 52519 | 34806792 |
Drug interaction | 253.96 | 10.59 | 159 | 97461 | 225787 | 34633524 |
Fatigue | 157.38 | 10.59 | 1652 | 95968 | 369001 | 34490310 |
Toxicity to various agents | 134.76 | 10.59 | 220 | 97400 | 200142 | 34659169 |
Blood pressure increased | 128.62 | 10.59 | 537 | 97083 | 87565 | 34771746 |
Blood pressure diastolic abnormal | 124.23 | 10.59 | 105 | 97515 | 4713 | 34854598 |
Chills | 117.52 | 10.59 | 493 | 97127 | 80550 | 34778761 |
Back pain | 106.46 | 10.59 | 642 | 96978 | 121147 | 34738164 |
Heart rate decreased | 96.94 | 10.59 | 249 | 97371 | 31496 | 34827815 |
Cough | 89.06 | 10.59 | 720 | 96900 | 149420 | 34709891 |
Acute kidney injury | 87.64 | 10.59 | 497 | 97123 | 304491 | 34554820 |
Arthralgia | 82.94 | 10.59 | 781 | 96839 | 169260 | 34690051 |
Blood pressure systolic increased | 77.40 | 10.59 | 187 | 97433 | 22765 | 34836546 |
Blood pressure systolic abnormal | 76.04 | 10.59 | 73 | 97547 | 3875 | 34855436 |
Blood pressure fluctuation | 73.95 | 10.59 | 195 | 97425 | 25054 | 34834257 |
Pain | 72.25 | 10.59 | 881 | 96739 | 203794 | 34655517 |
General physical health deterioration | 71.91 | 10.59 | 157 | 97463 | 128112 | 34731199 |
Cardiac failure | 69.23 | 10.59 | 92 | 97528 | 91156 | 34768155 |
Sinusitis | 67.24 | 10.59 | 261 | 97359 | 41141 | 34818170 |
Rhabdomyolysis | 64.71 | 10.59 | 57 | 97563 | 68106 | 34791205 |
Completed suicide | 62.02 | 10.59 | 112 | 97508 | 98056 | 34761255 |
Pain in extremity | 60.58 | 10.59 | 579 | 97041 | 125934 | 34733377 |
Oxygen saturation decreased | 55.71 | 10.59 | 297 | 97323 | 53521 | 34805790 |
Hyperkalaemia | 52.58 | 10.59 | 70 | 97550 | 69319 | 34789992 |
Drug resistance | 51.48 | 10.59 | 6 | 97614 | 25921 | 34833390 |
Flushing | 50.71 | 10.59 | 202 | 97418 | 32218 | 34827093 |
C-reactive protein increased | 50.43 | 10.59 | 46 | 97574 | 54052 | 34805259 |
Throat irritation | 50.25 | 10.59 | 99 | 97521 | 10486 | 34848825 |
Chest discomfort | 49.83 | 10.59 | 291 | 97329 | 54239 | 34805072 |
Cholestasis | 49.35 | 10.59 | 8 | 97612 | 26940 | 34832371 |
Thrombocytopenia | 46.72 | 10.59 | 251 | 97369 | 155996 | 34703315 |
Drug reaction with eosinophilia and systemic symptoms | 46.48 | 10.59 | 17 | 97603 | 32995 | 34826316 |
Pulmonary function test decreased | 46.15 | 10.59 | 63 | 97557 | 4912 | 34854399 |
Agranulocytosis | 46.11 | 10.59 | 6 | 97614 | 23815 | 34835496 |
Multiple organ dysfunction syndrome | 44.31 | 10.59 | 92 | 97528 | 76474 | 34782837 |
Weight decreased | 41.78 | 10.59 | 708 | 96912 | 175593 | 34683718 |
Joint swelling | 40.89 | 10.59 | 297 | 97323 | 59593 | 34799718 |
Headache | 39.60 | 10.59 | 783 | 96837 | 199852 | 34659459 |
Vitamin D deficiency | 39.16 | 10.59 | 68 | 97552 | 6540 | 34852771 |
Rhinorrhoea | 38.60 | 10.59 | 158 | 97462 | 25510 | 34833801 |
Lactic acidosis | 38.21 | 10.59 | 25 | 97595 | 34747 | 34824564 |
Neutropenia | 37.94 | 10.59 | 269 | 97351 | 156509 | 34702802 |
Cytomegalovirus infection | 37.57 | 10.59 | 13 | 97607 | 26122 | 34833189 |
Product used for unknown indication | 37.47 | 10.59 | 27 | 97593 | 956 | 34858355 |
Renal impairment | 36.53 | 10.59 | 138 | 97482 | 94375 | 34764936 |
Peripheral swelling | 35.95 | 10.59 | 349 | 97271 | 76192 | 34783119 |
Heart rate increased | 35.87 | 10.59 | 237 | 97383 | 46106 | 34813205 |
Urticaria | 35.74 | 10.59 | 297 | 97323 | 62080 | 34797231 |
Coma | 35.71 | 10.59 | 45 | 97575 | 45633 | 34813678 |
Rheumatoid arthritis | 35.54 | 10.59 | 205 | 97415 | 38033 | 34821278 |
Myelosuppression | 34.65 | 10.59 | 6 | 97614 | 19259 | 34840052 |
Hepatic function abnormal | 34.37 | 10.59 | 44 | 97576 | 44319 | 34814992 |
Hypoglycaemia | 33.90 | 10.59 | 63 | 97557 | 54577 | 34804734 |
Nausea | 33.77 | 10.59 | 1212 | 96408 | 338696 | 34520615 |
Altered state of consciousness | 33.59 | 10.59 | 11 | 97609 | 22882 | 34836429 |
Abdominal discomfort | 33.27 | 10.59 | 283 | 97337 | 59552 | 34799759 |
Nephrolithiasis | 33.17 | 10.59 | 170 | 97450 | 30163 | 34829148 |
Hyperhidrosis | 33.07 | 10.59 | 340 | 97280 | 75352 | 34783959 |
Blood pressure diastolic increased | 32.81 | 10.59 | 54 | 97566 | 4971 | 34854340 |
Pancreatitis acute | 32.63 | 10.59 | 19 | 97601 | 28122 | 34831189 |
Rash | 32.53 | 10.59 | 833 | 96787 | 221919 | 34637392 |
Leukopenia | 31.93 | 10.59 | 81 | 97539 | 62775 | 34796536 |
Nasopharyngitis | 31.86 | 10.59 | 317 | 97303 | 69651 | 34789660 |
Neck pain | 31.24 | 10.59 | 147 | 97473 | 25202 | 34834109 |
Circulatory collapse | 31.06 | 10.59 | 10 | 97610 | 21028 | 34838283 |
Interstitial lung disease | 30.99 | 10.59 | 87 | 97533 | 65195 | 34794116 |
Bone marrow failure | 30.85 | 10.59 | 22 | 97598 | 29231 | 34830080 |
Sleep disorder due to general medical condition, insomnia type | 30.52 | 10.59 | 27 | 97593 | 1289 | 34858022 |
Gamma-glutamyltransferase increased | 29.51 | 10.59 | 23 | 97597 | 29208 | 34830103 |
Bronchitis | 29.15 | 10.59 | 209 | 97411 | 41754 | 34817557 |
Septic shock | 28.99 | 10.59 | 103 | 97517 | 71731 | 34787580 |
Maternal exposure before pregnancy | 28.50 | 10.59 | 21 | 97599 | 770 | 34858541 |
Pancytopenia | 28.33 | 10.59 | 153 | 97467 | 95004 | 34764307 |
Musculoskeletal stiffness | 27.67 | 10.59 | 224 | 97396 | 46456 | 34812855 |
Cerebral infarction | 27.22 | 10.59 | 22 | 97598 | 27433 | 34831878 |
Dyspnoea | 27.02 | 10.59 | 1298 | 96322 | 375484 | 34483827 |
Contusion | 26.36 | 10.59 | 183 | 97437 | 36181 | 34823130 |
Bone pain | 26.25 | 10.59 | 121 | 97499 | 20565 | 34838746 |
Hospice care | 26.07 | 10.59 | 59 | 97561 | 6881 | 34852430 |
Melaena | 25.48 | 10.59 | 37 | 97583 | 35343 | 34823968 |
Throat tightness | 24.92 | 10.59 | 65 | 97555 | 8293 | 34851018 |
Mucosal inflammation | 24.43 | 10.59 | 44 | 97576 | 38578 | 34820733 |
Depressed level of consciousness | 24.33 | 10.59 | 52 | 97568 | 42789 | 34816522 |
Muscle spasms | 24.30 | 10.59 | 318 | 97302 | 74683 | 34784628 |
Bradycardia | 24.29 | 10.59 | 118 | 97502 | 75300 | 34784011 |
Osteonecrosis | 23.97 | 10.59 | 6 | 97614 | 14884 | 34844427 |
Foetal exposure during pregnancy | 23.57 | 10.59 | 44 | 97576 | 38057 | 34821254 |
Dental caries | 23.44 | 10.59 | 44 | 97576 | 4495 | 34854816 |
Chronic obstructive pulmonary disease | 23.42 | 10.59 | 224 | 97396 | 48694 | 34810617 |
Pleural thickening | 23.01 | 10.59 | 14 | 97606 | 371 | 34858940 |
Drug ineffective | 22.89 | 10.59 | 1043 | 96577 | 455708 | 34403603 |
Anxiety | 22.68 | 10.59 | 397 | 97223 | 99031 | 34760280 |
Labelled drug-drug interaction medication error | 22.23 | 10.59 | 7 | 97613 | 14932 | 34844379 |
Emotional distress | 22.20 | 10.59 | 92 | 97528 | 14934 | 34844377 |
Weight increased | 22.13 | 10.59 | 374 | 97246 | 92659 | 34766652 |
Pharyngeal paraesthesia | 22.05 | 10.59 | 17 | 97603 | 668 | 34858643 |
Metabolic acidosis | 21.64 | 10.59 | 57 | 97563 | 43623 | 34815688 |
Productive cough | 21.63 | 10.59 | 180 | 97440 | 37633 | 34821678 |
Condition aggravated | 21.34 | 10.59 | 393 | 97227 | 191803 | 34667508 |
Drug hypersensitivity | 21.12 | 10.59 | 329 | 97291 | 80200 | 34779111 |
Body temperature decreased | 21.01 | 10.59 | 82 | 97538 | 12952 | 34846359 |
Epilepsy | 20.36 | 10.59 | 18 | 97602 | 21477 | 34837834 |
Eosinophilia | 20.32 | 10.59 | 26 | 97594 | 26196 | 34833115 |
Asthenia | 19.94 | 10.59 | 856 | 96764 | 244395 | 34614916 |
Hyponatraemia | 19.91 | 10.59 | 142 | 97478 | 82549 | 34776762 |
Constipation | 19.58 | 10.59 | 511 | 97109 | 136471 | 34722840 |
Post concussion syndrome | 19.56 | 10.59 | 9 | 97611 | 132 | 34859179 |
Neutropenic sepsis | 19.53 | 10.59 | 7 | 97613 | 13760 | 34845551 |
Ascites | 19.31 | 10.59 | 66 | 97554 | 46505 | 34812806 |
Hypoaesthesia | 19.27 | 10.59 | 259 | 97361 | 61185 | 34798126 |
Unevaluable event | 19.10 | 10.59 | 156 | 97464 | 32434 | 34826877 |
Pneumonia | 19.02 | 10.59 | 1214 | 96406 | 361413 | 34497898 |
Dyspepsia | 18.99 | 10.59 | 171 | 97449 | 36561 | 34822750 |
Pruritus | 18.97 | 10.59 | 525 | 97095 | 141456 | 34717855 |
Feeling hot | 18.74 | 10.59 | 105 | 97515 | 19267 | 34840044 |
Nephropathy toxic | 18.55 | 10.59 | 6 | 97614 | 12582 | 34846729 |
Toxic epidermal necrolysis | 18.34 | 10.59 | 20 | 97600 | 21626 | 34837685 |
Blood creatine phosphokinase increased | 18.31 | 10.59 | 64 | 97556 | 44793 | 34814518 |
Oropharyngeal pain | 18.25 | 10.59 | 165 | 97455 | 35320 | 34823991 |
Pneumocystis jirovecii pneumonia | 18.08 | 10.59 | 17 | 97603 | 19693 | 34839618 |
C-reactive protein decreased | 18.04 | 10.59 | 25 | 97595 | 1977 | 34857334 |
Product use issue | 18.02 | 10.59 | 262 | 97358 | 62954 | 34796357 |
Anaemia | 18.00 | 10.59 | 505 | 97115 | 232830 | 34626481 |
Injury | 17.99 | 10.59 | 109 | 97511 | 20578 | 34838733 |
Upper-airway cough syndrome | 17.77 | 10.59 | 34 | 97586 | 3524 | 34855787 |
Cerebral haemorrhage | 17.76 | 10.59 | 45 | 97575 | 34892 | 34824419 |
Extrapyramidal disorder | 17.52 | 10.59 | 7 | 97613 | 12873 | 34846438 |
Osteoarthritis | 17.46 | 10.59 | 108 | 97512 | 20534 | 34838777 |
Nightmare | 17.40 | 10.59 | 83 | 97537 | 14308 | 34845003 |
Infusion site pruritus | 17.35 | 10.59 | 16 | 97604 | 807 | 34858504 |
Drug eruption | 17.28 | 10.59 | 18 | 97602 | 19880 | 34839431 |
Hypoxia | 17.17 | 10.59 | 232 | 97388 | 54863 | 34804448 |
Delirium | 17.13 | 10.59 | 64 | 97556 | 43927 | 34815384 |
Overdose | 17.11 | 10.59 | 167 | 97453 | 90892 | 34768419 |
Illness | 17.06 | 10.59 | 79 | 97541 | 13450 | 34845861 |
Electrocardiogram QT prolonged | 17 | 10.59 | 58 | 97562 | 40894 | 34818417 |
Wheezing | 16.67 | 10.59 | 183 | 97437 | 41219 | 34818092 |
Paranasal sinus hypersecretion | 16.60 | 10.59 | 17 | 97603 | 976 | 34858335 |
Intentional self-injury | 16.39 | 10.59 | 9 | 97611 | 13762 | 34845549 |
Dry skin | 16.35 | 10.59 | 146 | 97474 | 31141 | 34828170 |
Jaundice | 16.25 | 10.59 | 41 | 97579 | 31841 | 34827470 |
Bladder cancer | 16.19 | 10.59 | 13 | 97607 | 16265 | 34843046 |
Tubulointerstitial nephritis | 16.13 | 10.59 | 21 | 97599 | 21003 | 34838308 |
Joint effusion | 16.12 | 10.59 | 41 | 97579 | 5152 | 34854159 |
Hip fracture | 16.06 | 10.59 | 71 | 97549 | 11854 | 34847457 |
Hypocalcaemia | 15.97 | 10.59 | 27 | 97593 | 24262 | 34835049 |
Therapy non-responder | 15.87 | 10.59 | 56 | 97564 | 39090 | 34820221 |
Nervous system neoplasm | 15.62 | 10.59 | 8 | 97612 | 150 | 34859161 |
Progressive multifocal leukoencephalopathy | 15.59 | 10.59 | 4 | 97616 | 9760 | 34849551 |
Hot flush | 15.58 | 10.59 | 95 | 97525 | 17971 | 34841340 |
Death | 15.48 | 10.59 | 1301 | 96319 | 396748 | 34462563 |
Diabetes mellitus | 15.29 | 10.59 | 73 | 97547 | 46800 | 34812511 |
Peritonitis | 15.14 | 10.59 | 14 | 97606 | 16351 | 34842960 |
Hypertension | 15.11 | 10.59 | 493 | 97127 | 135950 | 34723361 |
Miosis | 15.05 | 10.59 | 4 | 97616 | 9531 | 34849780 |
Nasal congestion | 14.96 | 10.59 | 113 | 97507 | 22944 | 34836367 |
Red blood cell count decreased | 14.82 | 10.59 | 135 | 97485 | 28955 | 34830356 |
Drug intolerance | 14.72 | 10.59 | 241 | 97379 | 59329 | 34799982 |
Treatment failure | 14.49 | 10.59 | 74 | 97546 | 46623 | 34812688 |
Acute respiratory failure | 14.49 | 10.59 | 141 | 97479 | 30787 | 34828524 |
Cardio-respiratory arrest | 14.26 | 10.59 | 93 | 97527 | 55180 | 34804131 |
Poor venous access | 14.13 | 10.59 | 39 | 97581 | 5144 | 34854167 |
Graft versus host disease | 13.96 | 10.59 | 6 | 97614 | 10563 | 34848748 |
Type IIa hyperlipidaemia | 13.93 | 10.59 | 8 | 97612 | 190 | 34859121 |
Haematotoxicity | 13.79 | 10.59 | 3 | 97617 | 8191 | 34851120 |
Arthritis | 13.77 | 10.59 | 141 | 97479 | 31205 | 34828106 |
Haemarthrosis | 13.71 | 10.59 | 29 | 97591 | 3230 | 34856081 |
Aplastic anaemia | 13.68 | 10.59 | 5 | 97615 | 9711 | 34849600 |
Urinary tract infection | 13.60 | 10.59 | 319 | 97301 | 83762 | 34775549 |
Anuria | 13.55 | 10.59 | 6 | 97614 | 10379 | 34848932 |
Plasma cell myeloma | 13.51 | 10.59 | 178 | 97442 | 41859 | 34817452 |
Influenza | 13.43 | 10.59 | 204 | 97416 | 49462 | 34809849 |
Lymphocyte count | 13.29 | 10.59 | 6 | 97614 | 84 | 34859227 |
Ill-defined disorder | 13.20 | 10.59 | 75 | 97545 | 13834 | 34845477 |
Snapping hip syndrome | 13.14 | 10.59 | 4 | 97616 | 16 | 34859295 |
Aggression | 13.11 | 10.59 | 60 | 97560 | 38904 | 34820407 |
Cardiogenic shock | 12.98 | 10.59 | 35 | 97585 | 26583 | 34832728 |
Failure to thrive | 12.97 | 10.59 | 53 | 97567 | 8548 | 34850763 |
Haematochezia | 12.92 | 10.59 | 192 | 97428 | 46342 | 34812969 |
Angioedema | 12.90 | 10.59 | 57 | 97563 | 37317 | 34821994 |
Urethral meatus stenosis | 12.84 | 10.59 | 5 | 97615 | 47 | 34859264 |
Psychotic disorder | 12.81 | 10.59 | 31 | 97589 | 24421 | 34834890 |
Dizziness | 12.80 | 10.59 | 739 | 96881 | 217782 | 34641529 |
Vitello-intestinal duct remnant | 12.79 | 10.59 | 7 | 97613 | 151 | 34859160 |
Rash maculo-papular | 12.71 | 10.59 | 39 | 97581 | 28412 | 34830899 |
Flatulence | 12.71 | 10.59 | 102 | 97518 | 21096 | 34838215 |
Tooth disorder | 12.60 | 10.59 | 62 | 97558 | 10820 | 34848491 |
Increased tendency to bruise | 12.54 | 10.59 | 32 | 97588 | 4029 | 34855282 |
Anhedonia | 12.45 | 10.59 | 48 | 97572 | 7537 | 34851774 |
Drug level increased | 12.40 | 10.59 | 27 | 97593 | 22069 | 34837242 |
Lymphocyte count abnormal | 12.39 | 10.59 | 16 | 97604 | 1182 | 34858129 |
Polyneuropathy | 12.36 | 10.59 | 14 | 97606 | 14882 | 34844429 |
Musculoskeletal pain | 12.29 | 10.59 | 140 | 97480 | 31823 | 34827488 |
Chest pain | 12.27 | 10.59 | 451 | 97169 | 126311 | 34733000 |
Ischaemic stroke | 12.26 | 10.59 | 20 | 97600 | 18230 | 34841081 |
Liver disorder | 12.21 | 10.59 | 49 | 97571 | 32948 | 34826363 |
Infusion site extravasation | 12.16 | 10.59 | 33 | 97587 | 4311 | 34855000 |
Anaphylactic shock | 12.15 | 10.59 | 16 | 97604 | 15925 | 34843386 |
Hypomagnesaemia | 12.01 | 10.59 | 27 | 97593 | 21824 | 34837487 |
Hepatic encephalopathy | 11.97 | 10.59 | 14 | 97606 | 14671 | 34844640 |
Cytomegalovirus viraemia | 11.95 | 10.59 | 3 | 97617 | 7427 | 34851884 |
Joint stiffness | 11.92 | 10.59 | 61 | 97559 | 10812 | 34848499 |
Respiratory rate increased | 11.91 | 10.59 | 57 | 97563 | 9837 | 34849474 |
Poisoning | 11.87 | 10.59 | 10 | 97610 | 12216 | 34847095 |
Thymic cancer metastatic | 11.84 | 10.59 | 5 | 97615 | 59 | 34859252 |
Discomfort | 11.83 | 10.59 | 92 | 97528 | 18846 | 34840465 |
Hypokalaemia | 11.69 | 10.59 | 105 | 97515 | 58109 | 34801202 |
Prostate cancer | 11.65 | 10.59 | 64 | 97556 | 39585 | 34819726 |
Fear | 11.65 | 10.59 | 59 | 97561 | 10417 | 34848894 |
Paranasal sinus discomfort | 11.61 | 10.59 | 13 | 97607 | 827 | 34858484 |
Hypersensitivity | 11.59 | 10.59 | 237 | 97383 | 60798 | 34798513 |
Pathogen resistance | 11.57 | 10.59 | 6 | 97614 | 9476 | 34849835 |
Cardiac arrest | 11.49 | 10.59 | 194 | 97426 | 95965 | 34763346 |
Blood pressure diastolic decreased | 11.39 | 10.59 | 53 | 97567 | 9041 | 34850270 |
White blood cell count decreased | 11.38 | 10.59 | 348 | 97272 | 95097 | 34764214 |
Photophobia | 11.38 | 10.59 | 44 | 97576 | 6920 | 34852391 |
Febrile neutropenia | 11.36 | 10.59 | 293 | 97327 | 136556 | 34722755 |
Hepatitis cholestatic | 11.34 | 10.59 | 4 | 97616 | 7943 | 34851368 |
Pemphigus | 11.29 | 10.59 | 18 | 97602 | 1613 | 34857698 |
Body temperature increased | 11.20 | 10.59 | 85 | 97535 | 17283 | 34842028 |
Feeling abnormal | 11.19 | 10.59 | 243 | 97377 | 62992 | 34796319 |
Bile output abnormal | 11.06 | 10.59 | 4 | 97616 | 30 | 34859281 |
Generalised tonic-clonic seizure | 10.97 | 10.59 | 27 | 97593 | 21147 | 34838164 |
Parkinsonian rest tremor | 10.94 | 10.59 | 6 | 97614 | 130 | 34859181 |
Sputum discoloured | 10.89 | 10.59 | 47 | 97573 | 7765 | 34851546 |
Arthropathy | 10.86 | 10.59 | 119 | 97501 | 26788 | 34832523 |
Gait disturbance | 10.85 | 10.59 | 313 | 97307 | 84827 | 34774484 |
Gastroenteritis viral | 10.82 | 10.59 | 44 | 97576 | 7080 | 34852231 |
Lip ulceration | 10.80 | 10.59 | 12 | 97608 | 757 | 34858554 |
Rhinalgia | 10.79 | 10.59 | 14 | 97606 | 1039 | 34858272 |
Aspergillus infection | 10.74 | 10.59 | 11 | 97609 | 12243 | 34847068 |
Gastrooesophageal reflux disease | 10.73 | 10.59 | 157 | 97463 | 37767 | 34821544 |
Oliguria | 10.69 | 10.59 | 5 | 97615 | 8375 | 34850936 |
Hepatotoxicity | 10.67 | 10.59 | 28 | 97592 | 21457 | 34837854 |
Appendix disorder | 10.59 | 10.59 | 11 | 97609 | 642 | 34858669 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug interaction | 755.75 | 9.84 | 299 | 296018 | 414884 | 79033187 |
Infusion related reaction | 508.32 | 9.84 | 1943 | 294374 | 228294 | 79219777 |
Toxicity to various agents | 500.79 | 9.84 | 497 | 295820 | 421043 | 79027028 |
Sinusitis | 404.65 | 9.84 | 1617 | 294700 | 193884 | 79254187 |
Nasopharyngitis | 352.96 | 9.84 | 1868 | 294449 | 252013 | 79196058 |
Irritable bowel syndrome | 341.93 | 9.84 | 731 | 295586 | 61510 | 79386561 |
Acute kidney injury | 338.37 | 9.84 | 909 | 295408 | 518495 | 78929576 |
Muscle injury | 332.23 | 9.84 | 625 | 295692 | 47936 | 79400135 |
Rheumatoid arthritis | 332.01 | 9.84 | 1594 | 294723 | 206876 | 79241195 |
Completed suicide | 326.06 | 9.84 | 261 | 296056 | 245506 | 79202565 |
Folliculitis | 302.56 | 9.84 | 649 | 295668 | 54731 | 79393340 |
Peripheral swelling | 292.07 | 9.84 | 1857 | 294460 | 267760 | 79180311 |
Fatigue | 277.59 | 9.84 | 4919 | 291398 | 924808 | 78523263 |
Blood pressure diastolic abnormal | 276.50 | 9.84 | 349 | 295968 | 18853 | 79429218 |
Sleep disorder due to general medical condition, insomnia type | 276.37 | 9.84 | 543 | 295774 | 43013 | 79405058 |
Pain | 264.59 | 9.84 | 3870 | 292447 | 699932 | 78748139 |
Blood pressure increased | 262.04 | 9.84 | 1508 | 294809 | 209852 | 79238219 |
Blood pressure fluctuation | 257.66 | 9.84 | 686 | 295631 | 66459 | 79381612 |
Lower respiratory tract infection | 242.14 | 9.84 | 1037 | 295280 | 128183 | 79319888 |
Weight increased | 231.37 | 9.84 | 1793 | 294524 | 275593 | 79172478 |
Blood pressure systolic increased | 224.07 | 9.84 | 651 | 295666 | 66335 | 79381736 |
Ill-defined disorder | 219.19 | 9.84 | 639 | 295678 | 65236 | 79382835 |
Blood pressure systolic abnormal | 213.48 | 9.84 | 291 | 296026 | 16956 | 79431115 |
Gastrointestinal disorder | 210.22 | 9.84 | 956 | 295361 | 121249 | 79326822 |
Back pain | 201.69 | 9.84 | 1868 | 294449 | 302312 | 79145759 |
Joint swelling | 198.16 | 9.84 | 1786 | 294531 | 286860 | 79161211 |
Impaired healing | 194.92 | 9.84 | 742 | 295575 | 86913 | 79361158 |
Arthralgia | 192.10 | 9.84 | 3086 | 293231 | 568717 | 78879354 |
Pruritus | 191.15 | 9.84 | 2274 | 294043 | 392374 | 79055697 |
Ear pain | 189.72 | 9.84 | 394 | 295923 | 32475 | 79415596 |
Contusion | 176.82 | 9.84 | 1050 | 295267 | 147726 | 79300345 |
Body temperature increased | 176.67 | 9.84 | 460 | 295857 | 43960 | 79404111 |
Cardiac failure | 172.89 | 9.84 | 192 | 296125 | 154650 | 79293421 |
Headache | 171.52 | 9.84 | 3393 | 292924 | 650379 | 78797692 |
Neutropenia | 167.69 | 9.84 | 530 | 295787 | 287180 | 79160891 |
Heart rate increased | 167.30 | 9.84 | 888 | 295429 | 119836 | 79328235 |
Muscle spasticity | 164.09 | 9.84 | 290 | 296027 | 21185 | 79426886 |
Blister | 163.64 | 9.84 | 876 | 295441 | 118600 | 79329471 |
Rhabdomyolysis | 161.53 | 9.84 | 91 | 296226 | 103040 | 79345031 |
Thrombocytopenia | 151.52 | 9.84 | 493 | 295824 | 264766 | 79183305 |
Anaemia | 143.42 | 9.84 | 1016 | 295301 | 443999 | 79004072 |
Night sweats | 142.40 | 9.84 | 472 | 295845 | 51623 | 79396448 |
Hepatocellular injury | 138.17 | 9.84 | 10 | 296307 | 47583 | 79400488 |
Oxygen saturation decreased | 137.13 | 9.84 | 885 | 295432 | 128162 | 79319909 |
Drug reaction with eosinophilia and systemic symptoms | 136.59 | 9.84 | 35 | 296282 | 64209 | 79383862 |
Hyperkalaemia | 136.53 | 9.84 | 134 | 296183 | 114264 | 79333807 |
Bursitis | 133.23 | 9.84 | 362 | 295955 | 35482 | 79412589 |
Lactic acidosis | 132.16 | 9.84 | 48 | 296269 | 70311 | 79377760 |
Pancytopenia | 130.16 | 9.84 | 262 | 296055 | 165483 | 79282588 |
Helicobacter infection | 128.66 | 9.84 | 557 | 295760 | 69147 | 79378924 |
Urticaria | 127.49 | 9.84 | 1147 | 295170 | 184054 | 79264017 |
Cholestasis | 126.03 | 9.84 | 21 | 296296 | 52088 | 79395983 |
Drug resistance | 125.09 | 9.84 | 8 | 296309 | 42205 | 79405866 |
Hyponatraemia | 124.94 | 9.84 | 299 | 296018 | 177549 | 79270522 |
General physical health deterioration | 124.01 | 9.84 | 563 | 295754 | 274675 | 79173396 |
Multiple organ dysfunction syndrome | 121.61 | 9.84 | 161 | 296156 | 120085 | 79327986 |
Temperature regulation disorder | 118.88 | 9.84 | 127 | 296190 | 5726 | 79442345 |
Heart rate decreased | 118.57 | 9.84 | 547 | 295770 | 69769 | 79378302 |
Stomatitis | 116.87 | 9.84 | 939 | 295378 | 145818 | 79302253 |
Hypersensitivity | 116.80 | 9.84 | 1488 | 294829 | 260751 | 79187320 |
Agranulocytosis | 116.19 | 9.84 | 15 | 296302 | 45015 | 79403056 |
Duodenal ulcer perforation | 111.59 | 9.84 | 515 | 295802 | 65696 | 79382375 |
Leukopenia | 107.93 | 9.84 | 166 | 296151 | 116347 | 79331724 |
Coma | 106.72 | 9.84 | 130 | 296187 | 100519 | 79347552 |
Hepatic function abnormal | 102.79 | 9.84 | 73 | 296244 | 73034 | 79375037 |
Electrocardiogram QT prolonged | 99.85 | 9.84 | 113 | 296204 | 90273 | 79357798 |
Food allergy | 98.42 | 9.84 | 158 | 296159 | 10666 | 79437405 |
Myelosuppression | 97.98 | 9.84 | 16 | 296301 | 40280 | 79407791 |
Oropharyngeal pain | 97.25 | 9.84 | 718 | 295599 | 108635 | 79339436 |
Septic shock | 96.49 | 9.84 | 194 | 296123 | 122607 | 79325464 |
Respiratory disorder | 95.83 | 9.84 | 375 | 295942 | 44481 | 79403590 |
Bone marrow failure | 95.76 | 9.84 | 35 | 296282 | 51072 | 79396999 |
Depressed level of consciousness | 95.11 | 9.84 | 132 | 296185 | 96520 | 79351551 |
Blood pressure diastolic increased | 94.30 | 9.84 | 183 | 296134 | 14359 | 79433712 |
Pain in extremity | 93.94 | 9.84 | 1888 | 294429 | 362650 | 79085421 |
Cytomegalovirus infection | 93.05 | 9.84 | 22 | 296295 | 42622 | 79405449 |
Chest discomfort | 91.94 | 9.84 | 849 | 295468 | 137195 | 79310876 |
Hypoglycaemia | 90.08 | 9.84 | 149 | 296168 | 101445 | 79346626 |
Cardiac arrest | 90.01 | 9.84 | 332 | 295985 | 171764 | 79276307 |
Circulatory collapse | 89.29 | 9.84 | 16 | 296301 | 37652 | 79410419 |
Altered state of consciousness | 89.17 | 9.84 | 26 | 296291 | 43796 | 79404275 |
Mucosal inflammation | 88.49 | 9.84 | 90 | 296227 | 75490 | 79372581 |
C-reactive protein increased | 88.18 | 9.84 | 220 | 296097 | 128807 | 79319264 |
Insomnia | 88.00 | 9.84 | 1339 | 294978 | 243831 | 79204240 |
Cough | 87.09 | 9.84 | 1877 | 294440 | 364912 | 79083159 |
Renal impairment | 84.09 | 9.84 | 302 | 296015 | 157481 | 79290590 |
Chills | 83.02 | 9.84 | 936 | 295381 | 159298 | 79288773 |
Toxic epidermal necrolysis | 82.73 | 9.84 | 31 | 296286 | 44550 | 79403521 |
Flushing | 81.02 | 9.84 | 584 | 295733 | 87684 | 79360387 |
Osteoarthritis | 80.92 | 9.84 | 579 | 295738 | 86730 | 79361341 |
Metabolic acidosis | 80.91 | 9.84 | 113 | 296204 | 82416 | 79365655 |
Discomfort | 80.85 | 9.84 | 767 | 295550 | 124850 | 79323221 |
Epilepsy | 79.98 | 9.84 | 26 | 296291 | 40834 | 79407237 |
Swelling | 79.87 | 9.84 | 1189 | 295128 | 215522 | 79232549 |
Pleural thickening | 79.51 | 9.84 | 75 | 296242 | 2907 | 79445164 |
Cardio-respiratory arrest | 78.12 | 9.84 | 180 | 296137 | 108330 | 79339741 |
Angioedema | 75.65 | 9.84 | 103 | 296214 | 75932 | 79372139 |
Throat irritation | 75.39 | 9.84 | 327 | 295990 | 40619 | 79407452 |
Bradycardia | 75.23 | 9.84 | 255 | 296062 | 135302 | 79312769 |
Pancreatitis acute | 73.13 | 9.84 | 47 | 296270 | 49557 | 79398514 |
Abdominal discomfort | 72.18 | 9.84 | 1321 | 294996 | 249406 | 79198665 |
Therapeutic product effect decreased | 70.86 | 9.84 | 925 | 295392 | 162938 | 79285133 |
Gamma-glutamyltransferase increased | 70.03 | 9.84 | 60 | 296257 | 54620 | 79393451 |
Pleural fibrosis | 68.52 | 9.84 | 81 | 296236 | 4086 | 79443985 |
Melaena | 68.48 | 9.84 | 75 | 296242 | 60815 | 79387256 |
Illness | 67.75 | 9.84 | 347 | 295970 | 46164 | 79401907 |
Presbyacusis | 67.31 | 9.84 | 65 | 296252 | 2595 | 79445476 |
Overdose | 67.08 | 9.84 | 405 | 295912 | 183801 | 79264270 |
Hepatic enzyme increased | 66.91 | 9.84 | 1001 | 295316 | 181609 | 79266462 |
Toxic skin eruption | 66.73 | 9.84 | 4 | 296313 | 22289 | 79425782 |
Blood pressure diastolic decreased | 66.49 | 9.84 | 255 | 296062 | 29961 | 79418110 |
Anxiety | 64.24 | 9.84 | 1288 | 295029 | 247224 | 79200847 |
Coeliac disease | 63.09 | 9.84 | 134 | 296183 | 11217 | 79436854 |
Hypotension | 62.90 | 9.84 | 1205 | 295112 | 439112 | 79008959 |
Rash maculo-papular | 62.05 | 9.84 | 70 | 296247 | 56008 | 79392063 |
Interstitial lung disease | 61.67 | 9.84 | 213 | 296104 | 112387 | 79335684 |
Scoliosis | 61.20 | 9.84 | 104 | 296213 | 7360 | 79440711 |
Rhinorrhoea | 61.20 | 9.84 | 488 | 295829 | 75586 | 79372485 |
Osteonecrosis of jaw | 60.98 | 9.84 | 43 | 296274 | 43183 | 79404888 |
Influenza | 60.87 | 9.84 | 743 | 295574 | 128863 | 79319208 |
Seizure | 60.26 | 9.84 | 432 | 295885 | 188402 | 79259669 |
Hypocalcaemia | 60.10 | 9.84 | 58 | 296259 | 49866 | 79398205 |
Dyspnoea | 59.69 | 9.84 | 3817 | 292500 | 853208 | 78594863 |
Drug abuse | 59.60 | 9.84 | 357 | 295960 | 162334 | 79285737 |
Poisoning deliberate | 57.52 | 9.84 | 3 | 296314 | 18825 | 79429246 |
Labelled drug-drug interaction medication error | 57.00 | 9.84 | 16 | 296301 | 27634 | 79420437 |
Hypokalaemia | 56.02 | 9.84 | 310 | 296007 | 143730 | 79304341 |
Arthropathy | 55.89 | 9.84 | 947 | 295370 | 176164 | 79271907 |
Blood magnesium increased | 55.75 | 9.84 | 67 | 296250 | 3439 | 79444632 |
Jaundice | 54.36 | 9.84 | 71 | 296246 | 53278 | 79394793 |
Infection | 54.14 | 9.84 | 1227 | 295090 | 240485 | 79207586 |
Orthostatic hypotension | 53.96 | 9.84 | 78 | 296239 | 56086 | 79391985 |
Rash | 52.43 | 9.84 | 2639 | 293678 | 575719 | 78872352 |
Renal failure | 51.69 | 9.84 | 487 | 295830 | 200481 | 79247590 |
Lip dry | 50.72 | 9.84 | 149 | 296168 | 15269 | 79432802 |
Blood creatine phosphokinase increased | 50.55 | 9.84 | 106 | 296211 | 65984 | 79382087 |
Cerebral infarction | 50.55 | 9.84 | 57 | 296260 | 45619 | 79402452 |
Febrile neutropenia | 50.35 | 9.84 | 582 | 295735 | 230417 | 79217654 |
Intentional self-injury | 48.77 | 9.84 | 30 | 296287 | 32389 | 79415682 |
Drug eruption | 48.44 | 9.84 | 55 | 296262 | 43880 | 79404191 |
Drug-induced liver injury | 48.13 | 9.84 | 109 | 296208 | 66008 | 79382063 |
Nasal congestion | 48.04 | 9.84 | 465 | 295852 | 76087 | 79371984 |
Device expulsion | 47.96 | 9.84 | 18 | 296299 | 25843 | 79422228 |
Nephropathy toxic | 47.70 | 9.84 | 9 | 296308 | 20410 | 79427661 |
Skin necrosis | 46.72 | 9.84 | 6 | 296311 | 18081 | 79429990 |
Osteonecrosis | 46.47 | 9.84 | 29 | 296288 | 31066 | 79417005 |
Weight decreased | 46.14 | 9.84 | 1683 | 294634 | 353515 | 79094556 |
Asthenia | 45.98 | 9.84 | 2333 | 293984 | 509356 | 78938715 |
Bronchial secretion retention | 45.95 | 9.84 | 66 | 296251 | 4038 | 79444033 |
Haematotoxicity | 45.80 | 9.84 | 3 | 296314 | 15516 | 79432555 |
Urine abnormality | 45.65 | 9.84 | 97 | 296220 | 8122 | 79439949 |
Bacterial disease carrier | 45.32 | 9.84 | 41 | 296276 | 1505 | 79446566 |
Suicide attempt | 45.32 | 9.84 | 157 | 296160 | 82775 | 79365296 |
Hepatotoxicity | 44.87 | 9.84 | 76 | 296241 | 51276 | 79396795 |
Ascites | 44.79 | 9.84 | 138 | 296179 | 75424 | 79372647 |
Immunodeficiency | 44.09 | 9.84 | 179 | 296138 | 21589 | 79426482 |
Anti-cyclic citrullinated peptide antibody positive | 44.09 | 9.84 | 488 | 295829 | 82655 | 79365416 |
Parkinsonism | 44.07 | 9.84 | 5 | 296312 | 16579 | 79431492 |
Cerebral haemorrhage | 43.69 | 9.84 | 93 | 296224 | 57580 | 79390491 |
Contraindicated product administered | 43.55 | 9.84 | 825 | 295492 | 156713 | 79291358 |
Feeling hot | 43.14 | 9.84 | 374 | 295943 | 59360 | 79388711 |
Facet joint syndrome | 42.85 | 9.84 | 115 | 296202 | 11187 | 79436884 |
Asthma | 42.84 | 9.84 | 723 | 295594 | 134372 | 79313699 |
Wound | 42.59 | 9.84 | 637 | 295680 | 115542 | 79332529 |
Neovascularisation | 42.49 | 9.84 | 36 | 296281 | 1209 | 79446862 |
Neutropenic sepsis | 42.19 | 9.84 | 24 | 296293 | 27040 | 79421031 |
Generalised tonic-clonic seizure | 42.16 | 9.84 | 61 | 296256 | 43849 | 79404222 |
Hand deformity | 42.16 | 9.84 | 580 | 295737 | 103339 | 79344732 |
Torsade de pointes | 42.06 | 9.84 | 10 | 296307 | 19302 | 79428769 |
Inappropriate antidiuretic hormone secretion | 41.50 | 9.84 | 23 | 296294 | 26290 | 79421781 |
Poisoning | 41.46 | 9.84 | 21 | 296296 | 25251 | 79422820 |
Productive cough | 41.30 | 9.84 | 506 | 295811 | 87825 | 79360246 |
Malignant neoplasm progression | 41.03 | 9.84 | 316 | 296001 | 135674 | 79312397 |
Pericarditis | 40.77 | 9.84 | 578 | 295739 | 103658 | 79344413 |
Shock haemorrhagic | 40.63 | 9.84 | 12 | 296305 | 20048 | 79428023 |
Haemodynamic instability | 39.89 | 9.84 | 8 | 296309 | 17374 | 79430697 |
Tubulointerstitial nephritis | 39.87 | 9.84 | 50 | 296267 | 38185 | 79409886 |
Hepatic failure | 39.79 | 9.84 | 107 | 296210 | 61105 | 79386966 |
Syncope | 39.14 | 9.84 | 452 | 295865 | 178997 | 79269074 |
Pneumocystis jirovecii pneumonia | 38.86 | 9.84 | 38 | 296279 | 32470 | 79415601 |
Sleep disorder | 38.85 | 9.84 | 488 | 295829 | 85189 | 79362882 |
Lower limb fracture | 38.68 | 9.84 | 180 | 296137 | 23035 | 79425036 |
Abdominal pain upper | 38.55 | 9.84 | 1097 | 295220 | 222722 | 79225349 |
Disorientation | 38.39 | 9.84 | 113 | 296204 | 62663 | 79385408 |
Lymphopenia | 37.37 | 9.84 | 35 | 296282 | 30522 | 79417549 |
Miosis | 36.79 | 9.84 | 7 | 296310 | 15782 | 79432289 |
Graft versus host disease | 36.46 | 9.84 | 6 | 296311 | 15020 | 79433051 |
Psychotic disorder | 36.43 | 9.84 | 61 | 296256 | 41341 | 79406730 |
Drug level increased | 36.22 | 9.84 | 57 | 296260 | 39594 | 79408477 |
Migraine | 36.18 | 9.84 | 490 | 295827 | 87003 | 79361068 |
Posterior reversible encephalopathy syndrome | 35.95 | 9.84 | 27 | 296290 | 26254 | 79421817 |
Weight fluctuation | 35.74 | 9.84 | 110 | 296207 | 11565 | 79436506 |
Upper respiratory tract infection | 35.04 | 9.84 | 504 | 295813 | 90664 | 79357407 |
Haematemesis | 35.00 | 9.84 | 90 | 296227 | 52174 | 79395897 |
Urine leukocyte esterase positive | 34.87 | 9.84 | 58 | 296259 | 4033 | 79444038 |
Alanine aminotransferase increased | 34.86 | 9.84 | 411 | 295906 | 162159 | 79285912 |
Panniculitis | 34.78 | 9.84 | 3 | 296314 | 12368 | 79435703 |
Muscle spasms | 34.54 | 9.84 | 872 | 295445 | 173858 | 79274213 |
Musculoskeletal stiffness | 34.48 | 9.84 | 873 | 295444 | 174135 | 79273936 |
Oliguria | 34.44 | 9.84 | 9 | 296308 | 16300 | 79431771 |
Sedation complication | 34.35 | 9.84 | 8 | 296309 | 15661 | 79432410 |
Osteopenia | 34.06 | 9.84 | 147 | 296170 | 18217 | 79429854 |
Peripheral venous disease | 33.97 | 9.84 | 133 | 296184 | 15776 | 79432295 |
Cyst | 33.97 | 9.84 | 121 | 296196 | 13719 | 79434352 |
Creatinine renal clearance decreased | 33.96 | 9.84 | 14 | 296303 | 18988 | 79429083 |
Neck pain | 33.95 | 9.84 | 429 | 295888 | 74988 | 79373083 |
Status epilepticus | 33.91 | 9.84 | 26 | 296291 | 25015 | 79423056 |
Hypomagnesaemia | 33.61 | 9.84 | 78 | 296239 | 46833 | 79401238 |
Myoclonus | 33.45 | 9.84 | 32 | 296285 | 27628 | 79420443 |
Dyskinesia | 33.25 | 9.84 | 73 | 296244 | 44700 | 79403371 |
Cardiogenic shock | 33.09 | 9.84 | 66 | 296251 | 41848 | 79406223 |
Sinus disorder | 32.99 | 9.84 | 168 | 296149 | 22296 | 79425775 |
Disease progression | 32.98 | 9.84 | 484 | 295833 | 183878 | 79264193 |
Hyperglycaemia | 32.75 | 9.84 | 142 | 296175 | 70193 | 79377878 |
Hepatitis cholestatic | 32.58 | 9.84 | 6 | 296311 | 13846 | 79434225 |
Stevens-Johnson syndrome | 32.38 | 9.84 | 60 | 296257 | 39106 | 79408965 |
Epstein-Barr virus infection | 32.33 | 9.84 | 7 | 296310 | 14409 | 79433662 |
Aplastic anaemia | 32.31 | 9.84 | 13 | 296304 | 17892 | 79430179 |
Fluid retention | 32.24 | 9.84 | 399 | 295918 | 69410 | 79378661 |
Product tampering | 32.23 | 9.84 | 20 | 296297 | 408 | 79447663 |
Product prescribing error | 31.71 | 9.84 | 75 | 296242 | 44738 | 79403333 |
Bronchopulmonary aspergillosis | 31.68 | 9.84 | 22 | 296295 | 22272 | 79425799 |
Deafness neurosensory | 31.16 | 9.84 | 75 | 296242 | 6823 | 79441248 |
Acute respiratory distress syndrome | 30.99 | 9.84 | 74 | 296243 | 43993 | 79404078 |
Ischaemic stroke | 30.86 | 9.84 | 47 | 296270 | 33084 | 79414987 |
Deep vein thrombosis postoperative | 30.79 | 9.84 | 99 | 296218 | 10653 | 79437418 |
Musculoskeletal pain | 30.72 | 9.84 | 543 | 295774 | 101811 | 79346260 |
Red cell distribution width increased | 30.60 | 9.84 | 125 | 296192 | 15117 | 79432954 |
Disseminated intravascular coagulation | 30.45 | 9.84 | 54 | 296263 | 35788 | 79412283 |
Hypothermia | 30.31 | 9.84 | 24 | 296293 | 22722 | 79425349 |
Pathogen resistance | 30.13 | 9.84 | 8 | 296309 | 14334 | 79433737 |
Thrombotic microangiopathy | 29.88 | 9.84 | 19 | 296298 | 20150 | 79427921 |
Epigastric discomfort | 29.59 | 9.84 | 80 | 296237 | 7816 | 79440255 |
Condition aggravated | 29.41 | 9.84 | 1542 | 294775 | 499582 | 78948489 |
Wrong technique in product usage process | 29.25 | 9.84 | 158 | 296159 | 73717 | 79374354 |
Dystonia | 29.25 | 9.84 | 22 | 296295 | 21377 | 79426694 |
Transplant rejection | 29.22 | 9.84 | 18 | 296299 | 19419 | 79428652 |
Hepatic encephalopathy | 29.17 | 9.84 | 28 | 296289 | 24138 | 79423933 |
COVID-19 | 29.16 | 9.84 | 780 | 295537 | 156894 | 79291177 |
Polyneuropathy | 29.14 | 9.84 | 28 | 296289 | 24123 | 79423948 |
Pemphigus | 29.07 | 9.84 | 526 | 295791 | 99056 | 79349015 |
Peritonitis | 28.88 | 9.84 | 37 | 296280 | 27999 | 79420072 |
Rib fracture | 28.64 | 9.84 | 190 | 296127 | 27757 | 79420314 |
Ejection fraction decreased | 28.56 | 9.84 | 53 | 296264 | 34524 | 79413547 |
Glossodynia | 28.49 | 9.84 | 541 | 295776 | 102796 | 79345275 |
Aspergillus infection | 28.45 | 9.84 | 18 | 296299 | 19143 | 79428928 |
Eosinophilia | 28.18 | 9.84 | 81 | 296236 | 45264 | 79402807 |
Hypoaesthesia | 28.14 | 9.84 | 869 | 295448 | 178483 | 79269588 |
Purpura | 28.11 | 9.84 | 19 | 296298 | 19508 | 79428563 |
Aspartate aminotransferase increased | 28.02 | 9.84 | 355 | 295962 | 138286 | 79309785 |
Neuroleptic malignant syndrome | 27.75 | 9.84 | 37 | 296280 | 27522 | 79420549 |
Serotonin syndrome | 27.57 | 9.84 | 81 | 296236 | 44946 | 79403125 |
Sputum discoloured | 27.45 | 9.84 | 156 | 296161 | 21587 | 79426484 |
Haematuria | 27.38 | 9.84 | 147 | 296170 | 68689 | 79379382 |
Ventricular fibrillation | 27.21 | 9.84 | 48 | 296269 | 31878 | 79416193 |
Acute graft versus host disease | 27.18 | 9.84 | 3 | 296314 | 10164 | 79437907 |
Product use in unapproved indication | 27.17 | 9.84 | 715 | 295602 | 249644 | 79198427 |
Infusion site extravasation | 27.09 | 9.84 | 91 | 296226 | 10017 | 79438054 |
Agitation | 26.76 | 9.84 | 239 | 296078 | 99476 | 79348595 |
Blood creatinine increased | 26.72 | 9.84 | 410 | 295907 | 154647 | 79293424 |
Cestode infection | 26.17 | 9.84 | 15 | 296302 | 263 | 79447808 |
Drug intolerance | 26.13 | 9.84 | 1216 | 295101 | 262903 | 79185168 |
Bladder cancer | 25.52 | 9.84 | 21 | 296296 | 19505 | 79428566 |
Dry eye | 25.51 | 9.84 | 229 | 296088 | 36702 | 79411369 |
Myelodysplastic syndrome | 25.42 | 9.84 | 46 | 296271 | 30255 | 79417816 |
Ventricular tachycardia | 25.27 | 9.84 | 76 | 296241 | 41859 | 79406212 |
Rheumatoid nodule | 25.05 | 9.84 | 17 | 296300 | 17421 | 79430650 |
Intentional overdose | 25.04 | 9.84 | 262 | 296055 | 105698 | 79342373 |
Prostate cancer | 24.90 | 9.84 | 54 | 296263 | 33214 | 79414857 |
Hyperhidrosis | 24.83 | 9.84 | 738 | 295579 | 150754 | 79297317 |
Lupus vasculitis | 24.69 | 9.84 | 19 | 296298 | 555 | 79447516 |
Colitis microscopic | 24.62 | 9.84 | 5 | 296312 | 10763 | 79437308 |
SARS-CoV-2 test positive | 24.25 | 9.84 | 97 | 296220 | 11619 | 79436452 |
Body temperature decreased | 24.12 | 9.84 | 203 | 296114 | 31942 | 79416129 |
Intentional product use issue | 24.12 | 9.84 | 738 | 295579 | 151374 | 79296697 |
Sinus congestion | 23.97 | 9.84 | 141 | 296176 | 19755 | 79428316 |
Hepatitis | 23.87 | 9.84 | 116 | 296201 | 55611 | 79392460 |
Product substitution issue | 23.84 | 9.84 | 24 | 296293 | 20232 | 79427839 |
Hallucination, auditory | 23.81 | 9.84 | 25 | 296292 | 20668 | 79427403 |
Granuloma skin | 23.80 | 9.84 | 3 | 296314 | 9171 | 79438900 |
Asphyxia | 23.76 | 9.84 | 7 | 296310 | 11713 | 79436358 |
Cognitive disorder | 23.76 | 9.84 | 157 | 296160 | 69769 | 79378302 |
Cytomegalovirus viraemia | 23.65 | 9.84 | 9 | 296308 | 12812 | 79435259 |
Oesophageal carcinoma | 23.63 | 9.84 | 6 | 296311 | 11078 | 79436993 |
Progressive multifocal leukoencephalopathy | 23.58 | 9.84 | 25 | 296292 | 20575 | 79427496 |
Platelet count decreased | 23.54 | 9.84 | 547 | 295770 | 194117 | 79253954 |
Ear pruritus | 23.36 | 9.84 | 49 | 296268 | 4066 | 79444005 |
Akathisia | 23.32 | 9.84 | 10 | 296307 | 13249 | 79434822 |
Feeling abnormal | 23.30 | 9.84 | 765 | 295552 | 158434 | 79289637 |
Hepatocellular carcinoma | 23.28 | 9.84 | 3 | 296314 | 9018 | 79439053 |
Bone cyst | 23.24 | 9.84 | 44 | 296273 | 3389 | 79444682 |
Acute myocardial infarction | 23.23 | 9.84 | 179 | 296138 | 76857 | 79371214 |
White blood cells urine positive | 23.22 | 9.84 | 62 | 296255 | 6013 | 79442058 |
Hyperthyroidism | 23.20 | 9.84 | 29 | 296288 | 22180 | 79425891 |
Stress | 23.06 | 9.84 | 420 | 295897 | 79192 | 79368879 |
Limb mass | 22.98 | 9.84 | 45 | 296272 | 3554 | 79444517 |
Adulterated product | 22.80 | 9.84 | 14 | 296303 | 280 | 79447791 |
Upper-airway cough syndrome | 22.77 | 9.84 | 95 | 296222 | 11598 | 79436473 |
Spinal meningioma benign | 22.74 | 9.84 | 10 | 296307 | 96 | 79447975 |
Suicidal ideation | 22.74 | 9.84 | 178 | 296139 | 76162 | 79371909 |
Diabetic ketoacidosis | 22.66 | 9.84 | 59 | 296258 | 34063 | 79414008 |
Enteritis | 22.63 | 9.84 | 13 | 296304 | 14570 | 79433501 |
Neuralgia | 22.54 | 9.84 | 206 | 296111 | 33178 | 79414893 |
Jaundice cholestatic | 22.40 | 9.84 | 7 | 296310 | 11277 | 79436794 |
Haemophagocytic lymphohistiocytosis | 22.31 | 9.84 | 29 | 296288 | 21808 | 79426263 |
Dry mouth | 22.31 | 9.84 | 455 | 295862 | 87564 | 79360507 |
Synovitis | 22.24 | 9.84 | 725 | 295592 | 150009 | 79298062 |
Delirium | 22.20 | 9.84 | 204 | 296113 | 84423 | 79363648 |
Autoimmune disorder | 22.17 | 9.84 | 121 | 296196 | 16491 | 79431580 |
Bronchitis | 22.11 | 9.84 | 639 | 295678 | 130005 | 79318066 |
Dysarthria | 21.89 | 9.84 | 154 | 296163 | 67468 | 79380603 |
Respiratory tract congestion | 21.88 | 9.84 | 138 | 296179 | 19816 | 79428255 |
Off label use | 21.81 | 9.84 | 2997 | 293320 | 904218 | 78543853 |
Sinus operation | 21.79 | 9.84 | 36 | 296281 | 2489 | 79445582 |
Accidental exposure to product | 21.70 | 9.84 | 53 | 296264 | 31269 | 79416802 |
Hyperthermia | 21.66 | 9.84 | 21 | 296296 | 18016 | 79430055 |
Pulmonary function test decreased | 21.58 | 9.84 | 70 | 296247 | 7567 | 79440504 |
Exposure to toxic agent | 21.47 | 9.84 | 4 | 296313 | 9154 | 79438917 |
Respiratory depression | 21.39 | 9.84 | 44 | 296273 | 27586 | 79420485 |
Throat tightness | 21.34 | 9.84 | 177 | 296140 | 27730 | 79420341 |
Systemic lupus erythematosus | 21.17 | 9.84 | 595 | 295722 | 120554 | 79327517 |
Injection site pain | 21.13 | 9.84 | 347 | 295970 | 129491 | 79318580 |
Osteosclerosis | 21.06 | 9.84 | 46 | 296271 | 3925 | 79444146 |
Haematoma | 21.02 | 9.84 | 111 | 296206 | 52084 | 79395987 |
Proteinuria | 20.98 | 9.84 | 57 | 296260 | 32445 | 79415626 |
Schizophrenia | 20.94 | 9.84 | 16 | 296301 | 15424 | 79432647 |
Skin toxicity | 20.90 | 9.84 | 3 | 296314 | 8311 | 79439760 |
Sneezing | 20.89 | 9.84 | 135 | 296182 | 19548 | 79428523 |
Shock | 20.84 | 9.84 | 87 | 296230 | 43461 | 79404610 |
Infusion site pain | 20.81 | 9.84 | 106 | 296211 | 14070 | 79434001 |
Superinfection | 20.77 | 9.84 | 52 | 296265 | 4850 | 79443221 |
Subarachnoid haemorrhage | 20.65 | 9.84 | 37 | 296280 | 24428 | 79423643 |
Acute coronary syndrome | 20.64 | 9.84 | 29 | 296288 | 21104 | 79426967 |
Product used for unknown indication | 20.56 | 9.84 | 27 | 296290 | 1517 | 79446554 |
Immune reconstitution inflammatory syndrome | 20.56 | 9.84 | 13 | 296304 | 13828 | 79434243 |
Congestive cardiomyopathy | 20.54 | 9.84 | 9 | 296308 | 11771 | 79436300 |
Cholangitis | 20.39 | 9.84 | 11 | 296306 | 12765 | 79435306 |
Nephrotic syndrome | 20.35 | 9.84 | 8 | 296309 | 11166 | 79436905 |
Red blood cells urine positive | 20.35 | 9.84 | 52 | 296265 | 4911 | 79443160 |
Dermatitis bullous | 20.32 | 9.84 | 14 | 296303 | 14231 | 79433840 |
BK virus infection | 20.31 | 9.84 | 4 | 296313 | 8800 | 79439271 |
Neurotoxicity | 20.27 | 9.84 | 58 | 296259 | 32460 | 79415611 |
Hypercalcaemia | 20.16 | 9.84 | 74 | 296243 | 38356 | 79409715 |
Wheezing | 20.12 | 9.84 | 572 | 295745 | 116092 | 79331979 |
Hypoalbuminaemia | 20.04 | 9.84 | 30 | 296287 | 21267 | 79426804 |
Therapy partial responder | 20.04 | 9.84 | 21 | 296296 | 17376 | 79430695 |
Pulse abnormal | 20.03 | 9.84 | 41 | 296276 | 3343 | 79444728 |
Tenosynovitis | 20.00 | 9.84 | 17 | 296300 | 15537 | 79432534 |
Death | 19.65 | 9.84 | 1825 | 294492 | 564689 | 78883382 |
Drug tolerance decreased | 19.54 | 9.84 | 12 | 296305 | 12966 | 79435105 |
Left ventricular dysfunction | 19.48 | 9.84 | 26 | 296291 | 19335 | 79428736 |
Drug withdrawal syndrome | 19.46 | 9.84 | 65 | 296252 | 34653 | 79413418 |
Hypertransaminasaemia | 19.42 | 9.84 | 10 | 296307 | 11914 | 79436157 |
Hallucination, visual | 19.23 | 9.84 | 60 | 296257 | 32669 | 79415402 |
Face oedema | 19.19 | 9.84 | 48 | 296269 | 28088 | 79419983 |
Magnesium deficiency | 19.19 | 9.84 | 17 | 296300 | 607 | 79447464 |
Arrhythmia | 19.13 | 9.84 | 141 | 296176 | 61131 | 79386940 |
Urinary sediment present | 19.06 | 9.84 | 34 | 296283 | 2501 | 79445570 |
Injection site erythema | 19.03 | 9.84 | 192 | 296125 | 78005 | 79370066 |
Immunosuppressant drug level increased | 19.03 | 9.84 | 5 | 296312 | 9022 | 79439049 |
Gastric cancer | 19.02 | 9.84 | 7 | 296310 | 10172 | 79437899 |
Sepsis | 18.97 | 9.84 | 813 | 295504 | 268615 | 79179456 |
Nervous system disorder | 18.96 | 9.84 | 45 | 296272 | 26811 | 79421260 |
X-ray abnormal | 18.95 | 9.84 | 56 | 296261 | 5757 | 79442314 |
Arteriovenous fistula occlusion | 18.92 | 9.84 | 16 | 296301 | 536 | 79447535 |
Type IIa hyperlipidaemia | 18.82 | 9.84 | 12 | 296305 | 257 | 79447814 |
Hepatitis acute | 18.77 | 9.84 | 18 | 296299 | 15524 | 79432547 |
Transaminases increased | 18.69 | 9.84 | 114 | 296203 | 51629 | 79396442 |
Chronic obstructive pulmonary disease | 18.59 | 9.84 | 432 | 295885 | 84987 | 79363084 |
Acute myeloid leukaemia | 18.59 | 9.84 | 56 | 296261 | 30829 | 79417242 |
Premenstrual syndrome | 18.57 | 9.84 | 16 | 296301 | 550 | 79447521 |
Blood bilirubin increased | 18.55 | 9.84 | 157 | 296160 | 66075 | 79381996 |
Hyperammonaemia | 18.53 | 9.84 | 9 | 296308 | 11084 | 79436987 |
Liver function test abnormal | 18.43 | 9.84 | 152 | 296165 | 64323 | 79383748 |
Potentiating drug interaction | 18.37 | 9.84 | 5 | 296312 | 8814 | 79439257 |
Poor venous access | 18.36 | 9.84 | 123 | 296194 | 18026 | 79430045 |
Concussion | 18.34 | 9.84 | 77 | 296240 | 9426 | 79438645 |
Influenza like illness | 18.28 | 9.84 | 371 | 295946 | 71336 | 79376735 |
Gait inability | 18.19 | 9.84 | 314 | 296003 | 58603 | 79389468 |
Claustrophobia | 18.15 | 9.84 | 23 | 296294 | 1247 | 79446824 |
Pulmonary alveolar haemorrhage | 18.09 | 9.84 | 10 | 296307 | 11447 | 79436624 |
Second primary malignancy | 18.06 | 9.84 | 16 | 296301 | 14334 | 79433737 |
Tooth disorder | 17.78 | 9.84 | 162 | 296155 | 26071 | 79422000 |
Alopecia | 17.77 | 9.84 | 1040 | 295277 | 230315 | 79217756 |
Muscle rigidity | 17.76 | 9.84 | 29 | 296288 | 19853 | 79428218 |
Skin ulcer | 17.69 | 9.84 | 123 | 296194 | 54027 | 79394044 |
Intestinal ischaemia | 17.69 | 9.84 | 14 | 296303 | 13256 | 79434815 |
Blood lactate dehydrogenase increased | 17.68 | 9.84 | 80 | 296237 | 39090 | 79408981 |
Cystitis haemorrhagic | 17.66 | 9.84 | 6 | 296311 | 9166 | 79438905 |
Liver disorder | 17.54 | 9.84 | 178 | 296139 | 72239 | 79375832 |
Joint range of motion decreased | 17.48 | 9.84 | 195 | 296122 | 33087 | 79414984 |
Leukoencephalopathy | 17.48 | 9.84 | 4 | 296313 | 7925 | 79440146 |
Blood urine present | 17.33 | 9.84 | 137 | 296180 | 21160 | 79426911 |
Mucormycosis | 17.27 | 9.84 | 5 | 296312 | 8464 | 79439607 |
Stress cardiomyopathy | 17.26 | 9.84 | 10 | 296307 | 11156 | 79436915 |
Bradyphrenia | 17.22 | 9.84 | 9 | 296308 | 10631 | 79437440 |
Vital capacity decreased | 17.19 | 9.84 | 27 | 296290 | 1789 | 79446282 |
Corneal epithelium defect | 17.13 | 9.84 | 17 | 296300 | 702 | 79447369 |
Gait disturbance | 16.94 | 9.84 | 938 | 295379 | 206568 | 79241503 |
Drug ineffective for unapproved indication | 16.92 | 9.84 | 116 | 296201 | 51122 | 79396949 |
Limb injury | 16.90 | 9.84 | 176 | 296141 | 29352 | 79418719 |
Hepatitis B | 16.85 | 9.84 | 5 | 296312 | 8327 | 79439744 |
Drug dependence | 16.81 | 9.84 | 86 | 296231 | 40683 | 79407388 |
Body temperature fluctuation | 16.78 | 9.84 | 41 | 296276 | 3766 | 79444305 |
Hot flush | 16.77 | 9.84 | 292 | 296025 | 54585 | 79393486 |
Respiratory failure | 16.75 | 9.84 | 528 | 295789 | 180383 | 79267688 |
Sternal fracture | 16.60 | 9.84 | 32 | 296285 | 2498 | 79445573 |
Anterior chamber cell | 16.53 | 9.84 | 19 | 296298 | 930 | 79447141 |
Gastrointestinal haemorrhage | 16.51 | 9.84 | 420 | 295897 | 147299 | 79300772 |
Catatonia | 16.39 | 9.84 | 6 | 296311 | 8750 | 79439321 |
Finger deformity | 16.38 | 9.84 | 63 | 296254 | 7411 | 79440660 |
International normalised ratio increased | 16.35 | 9.84 | 219 | 296098 | 84502 | 79363569 |
Therapeutic response shortened | 16.35 | 9.84 | 108 | 296209 | 15755 | 79432316 |
Nausea | 16.35 | 9.84 | 3901 | 292416 | 953295 | 78494776 |
Hypersensitivity vasculitis | 16.35 | 9.84 | 3 | 296314 | 6940 | 79441131 |
Eczema | 16.32 | 9.84 | 87 | 296230 | 40731 | 79407340 |
Tumour lysis syndrome | 16.20 | 9.84 | 41 | 296276 | 23898 | 79424173 |
Oedema peripheral | 16.18 | 9.84 | 769 | 295548 | 251519 | 79196552 |
Body height decreased | 16.16 | 9.84 | 69 | 296248 | 8511 | 79439560 |
Pharyngeal paraesthesia | 16.15 | 9.84 | 33 | 296284 | 2688 | 79445383 |
Dyspepsia | 16.09 | 9.84 | 523 | 295794 | 108164 | 79339907 |
Menstruation delayed | 16.06 | 9.84 | 23 | 296294 | 1403 | 79446668 |
Abortion spontaneous | 16.02 | 9.84 | 56 | 296261 | 29451 | 79418620 |
Pemphigoid | 16.00 | 9.84 | 20 | 296297 | 15295 | 79432776 |
Sedation | 15.92 | 9.84 | 120 | 296197 | 51775 | 79396296 |
Chronic graft versus host disease | 15.81 | 9.84 | 3 | 296314 | 6778 | 79441293 |
Lichen sclerosus | 15.81 | 9.84 | 19 | 296298 | 975 | 79447096 |
Disturbance in attention | 15.81 | 9.84 | 117 | 296200 | 50684 | 79397387 |
Encephalopathy | 15.78 | 9.84 | 167 | 296150 | 67230 | 79380841 |
Ileus paralytic | 15.77 | 9.84 | 8 | 296309 | 9612 | 79438459 |
Culture urine positive | 15.69 | 9.84 | 44 | 296273 | 4391 | 79443680 |
Bacterial test | 15.69 | 9.84 | 21 | 296296 | 1202 | 79446869 |
Post-traumatic neck syndrome | 15.64 | 9.84 | 28 | 296289 | 2066 | 79446005 |
Tardive dyskinesia | 15.60 | 9.84 | 10 | 296307 | 10561 | 79437510 |
Aggression | 15.56 | 9.84 | 118 | 296199 | 50840 | 79397231 |
Fibromyalgia | 15.45 | 9.84 | 330 | 295987 | 64010 | 79384061 |
Lip pruritus | 15.45 | 9.84 | 18 | 296299 | 894 | 79447177 |
Pulmonary tuberculosis | 15.40 | 9.84 | 5 | 296312 | 7860 | 79440211 |
Maternal exposure timing unspecified | 15.40 | 9.84 | 52 | 296265 | 5740 | 79442331 |
Injury | 15.37 | 9.84 | 387 | 295930 | 77109 | 79370962 |
Large intestine perforation | 15.24 | 9.84 | 19 | 296298 | 14548 | 79433523 |
Hyperbilirubinaemia | 15.08 | 9.84 | 44 | 296273 | 24474 | 79423597 |
Dental caries | 15.05 | 9.84 | 85 | 296232 | 11735 | 79436336 |
Urogenital prolapse | 15.02 | 9.84 | 5 | 296312 | 20 | 79448051 |
Failure to thrive | 14.96 | 9.84 | 85 | 296232 | 11759 | 79436312 |
Specific gravity urine increased | 14.94 | 9.84 | 13 | 296304 | 453 | 79447618 |
Haemodialysis | 14.87 | 9.84 | 28 | 296289 | 18140 | 79429931 |
Renal tubular disorder | 14.85 | 9.84 | 3 | 296314 | 6483 | 79441588 |
Soft tissue injury | 14.85 | 9.84 | 25 | 296292 | 1756 | 79446315 |
Cataract | 14.72 | 9.84 | 318 | 295999 | 61802 | 79386269 |
Hip fracture | 14.71 | 9.84 | 177 | 296140 | 30584 | 79417487 |
Diabetes mellitus | 14.64 | 9.84 | 204 | 296113 | 78186 | 79369885 |
Urinary tract infection | 14.59 | 9.84 | 1197 | 295120 | 273315 | 79174756 |
Pancreatitis | 14.45 | 9.84 | 174 | 296143 | 68401 | 79379670 |
Acute pulmonary oedema | 14.43 | 9.84 | 19 | 296298 | 14211 | 79433860 |
C-reactive protein | 14.40 | 9.84 | 46 | 296271 | 4933 | 79443138 |
Atelectasis | 14.30 | 9.84 | 183 | 296134 | 32074 | 79415997 |
Ulcer | 14.26 | 9.84 | 60 | 296257 | 29912 | 79418159 |
Nerve compression | 14.21 | 9.84 | 70 | 296247 | 9169 | 79438902 |
Mania | 14.20 | 9.84 | 29 | 296288 | 18231 | 79429840 |
Myocardial ischaemia | 14.15 | 9.84 | 48 | 296269 | 25471 | 79422600 |
Cushingoid | 14.15 | 9.84 | 9 | 296308 | 9543 | 79438528 |
Sudden death | 14.14 | 9.84 | 40 | 296277 | 22471 | 79425600 |
Myocarditis | 14.11 | 9.84 | 38 | 296279 | 21695 | 79426376 |
Rash erythematous | 14.10 | 9.84 | 297 | 296020 | 57472 | 79390599 |
Polymenorrhoea | 14.09 | 9.84 | 18 | 296299 | 984 | 79447087 |
Infusion site erythema | 14.07 | 9.84 | 71 | 296246 | 9389 | 79438682 |
Scratch | 14.05 | 9.84 | 65 | 296252 | 8298 | 79439773 |
Nephrolithiasis | 14.01 | 9.84 | 277 | 296040 | 53014 | 79395057 |
C-reactive protein abnormal | 13.94 | 9.84 | 255 | 296062 | 48112 | 79399959 |
Disability assessment scale score increased | 13.94 | 9.84 | 36 | 296281 | 3422 | 79444649 |
Partial seizures | 13.94 | 9.84 | 8 | 296309 | 8970 | 79439101 |
Vein collapse | 13.91 | 9.84 | 19 | 296298 | 1109 | 79446962 |
Constipation | 13.90 | 9.84 | 1227 | 295090 | 281823 | 79166248 |
Adenovirus infection | 13.89 | 9.84 | 7 | 296310 | 8440 | 79439631 |
Joint stiffness | 13.85 | 9.84 | 221 | 296096 | 40609 | 79407462 |
Urinary retention | 13.80 | 9.84 | 139 | 296178 | 56491 | 79391580 |
Encephalitis | 13.69 | 9.84 | 21 | 296296 | 14739 | 79433332 |
Noninfective gingivitis | 13.68 | 9.84 | 23 | 296294 | 1613 | 79446458 |
Arteriospasm coronary | 13.63 | 9.84 | 4 | 296313 | 6712 | 79441359 |
Endometrial disorder | 13.62 | 9.84 | 14 | 296303 | 603 | 79447468 |
Staphylococcal sepsis | 13.61 | 9.84 | 21 | 296296 | 14705 | 79433366 |
Lower respiratory tract congestion | 13.50 | 9.84 | 39 | 296278 | 3958 | 79444113 |
Hepatosplenomegaly | 13.50 | 9.84 | 3 | 296314 | 6066 | 79442005 |
Respiratory rate increased | 13.44 | 9.84 | 131 | 296186 | 21469 | 79426602 |
Hypothyroidism | 13.44 | 9.84 | 127 | 296190 | 52265 | 79395806 |
Oligomenorrhoea | 13.43 | 9.84 | 15 | 296302 | 711 | 79447360 |
Exposure during pregnancy | 13.42 | 9.84 | 280 | 296037 | 100852 | 79347219 |
Cutaneous vasculitis | 13.32 | 9.84 | 7 | 296310 | 8245 | 79439826 |
Human papilloma virus test positive | 13.30 | 9.84 | 13 | 296304 | 527 | 79447544 |
Abnormal behaviour | 13.28 | 9.84 | 80 | 296237 | 36341 | 79411730 |
Unintentional medical device removal | 13.28 | 9.84 | 6 | 296311 | 7706 | 79440365 |
Loss of consciousness | 13.27 | 9.84 | 500 | 295817 | 167443 | 79280628 |
Sputum culture | 13.19 | 9.84 | 9 | 296308 | 217 | 79447854 |
Gynaecomastia | 13.19 | 9.84 | 6 | 296311 | 7675 | 79440396 |
Tongue oedema | 13.12 | 9.84 | 5 | 296312 | 7112 | 79440959 |
Hepatic cirrhosis | 13.09 | 9.84 | 76 | 296241 | 34830 | 79413241 |
Device use error | 13.07 | 9.84 | 5 | 296312 | 7096 | 79440975 |
Uterine leiomyoma | 13.06 | 9.84 | 53 | 296264 | 6390 | 79441681 |
Muscle strain | 13.03 | 9.84 | 70 | 296247 | 9485 | 79438586 |
Chest pain | 12.99 | 9.84 | 1218 | 295099 | 281086 | 79166985 |
White coat hypertension | 12.97 | 9.84 | 16 | 296301 | 844 | 79447227 |
Toxic encephalopathy | 12.96 | 9.84 | 14 | 296303 | 11426 | 79436645 |
Blood lactic acid increased | 12.94 | 9.84 | 17 | 296300 | 12727 | 79435344 |
Hypertriglyceridaemia | 12.93 | 9.84 | 17 | 296300 | 12723 | 79435348 |
Ligament sprain | 12.88 | 9.84 | 90 | 296227 | 13374 | 79434697 |
Hypovolaemic shock | 12.85 | 9.84 | 16 | 296301 | 12260 | 79435811 |
Multiple sclerosis | 12.84 | 9.84 | 133 | 296184 | 22149 | 79425922 |
Electrolyte imbalance | 12.81 | 9.84 | 65 | 296252 | 30816 | 79417255 |
Head discomfort | 12.75 | 9.84 | 95 | 296222 | 14407 | 79433664 |
Palpitations | 12.74 | 9.84 | 584 | 295733 | 126026 | 79322045 |
Metastases to liver | 12.67 | 9.84 | 58 | 296259 | 28256 | 79419815 |
Necrosis | 12.67 | 9.84 | 10 | 296307 | 9483 | 79438588 |
Pulmonary haemorrhage | 12.66 | 9.84 | 22 | 296295 | 14695 | 79433376 |
Renal tubular necrosis | 12.62 | 9.84 | 49 | 296268 | 24990 | 79423081 |
Pneumonia aspiration | 12.60 | 9.84 | 174 | 296143 | 66793 | 79381278 |
Myopathy | 12.58 | 9.84 | 37 | 296280 | 20526 | 79427545 |
Blood alkaline phosphatase increased | 12.49 | 9.84 | 164 | 296153 | 63500 | 79384571 |
Gastric disorder | 12.47 | 9.84 | 202 | 296115 | 37231 | 79410840 |
Cerebral haematoma | 12.44 | 9.84 | 7 | 296310 | 7935 | 79440136 |
Band sensation | 12.43 | 9.84 | 15 | 296302 | 773 | 79447298 |
Behaviour disorder | 12.38 | 9.84 | 4 | 296313 | 6309 | 79441762 |
Metastases to lung | 12.38 | 9.84 | 31 | 296286 | 18132 | 79429939 |
Poor quality sleep | 12.33 | 9.84 | 134 | 296183 | 22588 | 79425483 |
Emotional distress | 12.33 | 9.84 | 213 | 296104 | 39756 | 79408315 |
Feeling cold | 12.33 | 9.84 | 162 | 296155 | 28567 | 79419504 |
Blue toe syndrome | 12.31 | 9.84 | 13 | 296304 | 578 | 79447493 |
Dermatitis allergic | 12.31 | 9.84 | 31 | 296286 | 18099 | 79429972 |
Inappropriate schedule of product administration | 12.30 | 9.84 | 611 | 295706 | 133017 | 79315054 |
Euglycaemic diabetic ketoacidosis | 12.30 | 9.84 | 5 | 296312 | 6839 | 79441232 |
Dry throat | 12.29 | 9.84 | 59 | 296258 | 7647 | 79440424 |
Urine ketone body present | 12.25 | 9.84 | 35 | 296282 | 3530 | 79444541 |
Enterocolitis | 12.20 | 9.84 | 22 | 296295 | 14490 | 79433581 |
Klebsiella infection | 12.20 | 9.84 | 25 | 296292 | 15695 | 79432376 |
Post concussion syndrome | 12.19 | 9.84 | 13 | 296304 | 585 | 79447486 |
Faecaloma | 12.18 | 9.84 | 15 | 296302 | 11549 | 79436522 |
Urethral meatus stenosis | 12.16 | 9.84 | 5 | 296312 | 40 | 79448031 |
Snapping hip syndrome | 12.02 | 9.84 | 4 | 296313 | 16 | 79448055 |
Eye infection viral | 12.00 | 9.84 | 7 | 296310 | 127 | 79447944 |
Hepatitis fulminant | 11.96 | 9.84 | 6 | 296311 | 7256 | 79440815 |
Multiple sclerosis relapse | 11.94 | 9.84 | 241 | 296076 | 46292 | 79401779 |
Creatinine urine decreased | 11.93 | 9.84 | 9 | 296308 | 255 | 79447816 |
Drug ineffective | 11.92 | 9.84 | 3713 | 292604 | 1077200 | 78370871 |
Nephrogenic systemic fibrosis | 11.91 | 9.84 | 4 | 296313 | 6156 | 79441915 |
Pharyngeal disorder | 11.90 | 9.84 | 26 | 296291 | 2219 | 79445852 |
Oral pain | 11.90 | 9.84 | 175 | 296142 | 31623 | 79416448 |
Red blood cell sedimentation rate | 11.89 | 9.84 | 3 | 296314 | 5562 | 79442509 |
Infusion site swelling | 11.82 | 9.84 | 59 | 296258 | 7767 | 79440304 |
Pregnancy | 11.77 | 9.84 | 152 | 296165 | 26699 | 79421372 |
Hyperuricaemia | 11.72 | 9.84 | 16 | 296301 | 11783 | 79436288 |
Hyperpyrexia | 11.70 | 9.84 | 4 | 296313 | 6088 | 79441983 |
Duodenal ulcer haemorrhage | 11.68 | 9.84 | 6 | 296311 | 7157 | 79440914 |
Anhedonia | 11.67 | 9.84 | 95 | 296222 | 14803 | 79433268 |
Cytomegalovirus chorioretinitis | 11.65 | 9.84 | 3 | 296314 | 5487 | 79442584 |
Musculoskeletal chest pain | 11.63 | 9.84 | 142 | 296175 | 24622 | 79423449 |
Cardiac failure acute | 11.62 | 9.84 | 34 | 296283 | 18895 | 79429176 |
Salivary hypersecretion | 11.57 | 9.84 | 22 | 296295 | 14202 | 79433869 |
Diffuse large B-cell lymphoma | 11.54 | 9.84 | 17 | 296300 | 12132 | 79435939 |
Confusional state | 11.51 | 9.84 | 1350 | 294967 | 316647 | 79131424 |
Nitrite urine present | 11.48 | 9.84 | 18 | 296299 | 1191 | 79446880 |
Electrocardiogram QRS complex prolonged | 11.47 | 9.84 | 14 | 296303 | 10819 | 79437252 |
Hypogammaglobulinaemia | 11.47 | 9.84 | 19 | 296298 | 12932 | 79435139 |
Swollen joint count | 11.41 | 9.84 | 18 | 296299 | 1197 | 79446874 |
Blood cholesterol increased | 11.41 | 9.84 | 399 | 295918 | 83321 | 79364750 |
Peripheral ischaemia | 11.37 | 9.84 | 11 | 296306 | 9446 | 79438625 |
Reversible airways obstruction | 11.31 | 9.84 | 25 | 296292 | 2151 | 79445920 |
Hiatus hernia strangulated | 11.26 | 9.84 | 8 | 296309 | 206 | 79447865 |
Adrenal insufficiency | 11.24 | 9.84 | 61 | 296256 | 28426 | 79419645 |
Urine analysis abnormal | 11.19 | 9.84 | 51 | 296266 | 6469 | 79441602 |
Respiratory distress | 11.19 | 9.84 | 151 | 296166 | 58188 | 79389883 |
Injection site reaction | 11.17 | 9.84 | 140 | 296177 | 54645 | 79393426 |
Drug hypersensitivity | 11.09 | 9.84 | 1271 | 295046 | 297645 | 79150426 |
Sputum culture positive | 11.00 | 9.84 | 35 | 296282 | 3746 | 79444325 |
Infusion site pruritus | 10.97 | 9.84 | 37 | 296280 | 4081 | 79443990 |
Tachycardia | 10.97 | 9.84 | 544 | 295773 | 177224 | 79270847 |
Mycobacterial disease carrier | 10.84 | 9.84 | 4 | 296313 | 23 | 79448048 |
Erectile dysfunction | 10.81 | 9.84 | 24 | 296293 | 14640 | 79433431 |
Flail chest | 10.79 | 9.84 | 6 | 296311 | 99 | 79447972 |
Lip oedema | 10.74 | 9.84 | 5 | 296312 | 6311 | 79441760 |
Substance abuse | 10.73 | 9.84 | 14 | 296303 | 10512 | 79437559 |
Polyuria | 10.72 | 9.84 | 25 | 296292 | 14989 | 79433082 |
Hangover | 10.68 | 9.84 | 24 | 296293 | 2088 | 79445983 |
Knee deformity | 10.66 | 9.84 | 18 | 296299 | 1267 | 79446804 |
Cardiovascular disorder | 10.62 | 9.84 | 33 | 296284 | 17992 | 79430079 |
Vitello-intestinal duct remnant | 10.62 | 9.84 | 7 | 296310 | 159 | 79447912 |
Rash pustular | 10.58 | 9.84 | 16 | 296301 | 11295 | 79436776 |
Hepatitis toxic | 10.57 | 9.84 | 3 | 296314 | 5144 | 79442927 |
Genital haemorrhage | 10.56 | 9.84 | 5 | 296312 | 6250 | 79441821 |
Paraesthesia | 10.54 | 9.84 | 776 | 295541 | 175547 | 79272524 |
Maternal exposure before pregnancy | 10.53 | 9.84 | 38 | 296279 | 4335 | 79443736 |
Foreign body | 10.52 | 9.84 | 29 | 296288 | 2865 | 79445206 |
Personality disorder | 10.49 | 9.84 | 48 | 296269 | 6098 | 79441973 |
Endodontic procedure | 10.49 | 9.84 | 28 | 296289 | 2715 | 79445356 |
Toothache | 10.48 | 9.84 | 117 | 296200 | 19853 | 79428218 |
Femoral neck fracture | 10.47 | 9.84 | 13 | 296304 | 9971 | 79438100 |
Sinus headache | 10.47 | 9.84 | 42 | 296275 | 5038 | 79443033 |
Hospice care | 10.46 | 9.84 | 70 | 296247 | 10254 | 79437817 |
Subdural haematoma | 10.46 | 9.84 | 71 | 296246 | 31363 | 79416708 |
Palmar-plantar erythrodysaesthesia syndrome | 10.46 | 9.84 | 76 | 296241 | 33058 | 79415013 |
Seasonal allergy | 10.46 | 9.84 | 100 | 296217 | 16306 | 79431765 |
Extrapyramidal disorder | 10.43 | 9.84 | 46 | 296271 | 22633 | 79425438 |
Lung perforation | 10.38 | 9.84 | 6 | 296311 | 107 | 79447964 |
Hostility | 10.31 | 9.84 | 25 | 296292 | 2285 | 79445786 |
Respiratory arrest | 10.31 | 9.84 | 151 | 296166 | 57399 | 79390672 |
Tuberculosis | 10.31 | 9.84 | 26 | 296291 | 15172 | 79432899 |
Appendicitis | 10.29 | 9.84 | 41 | 296276 | 20753 | 79427318 |
Biopsy kidney | 10.28 | 9.84 | 7 | 296310 | 168 | 79447903 |
Coagulopathy | 10.24 | 9.84 | 85 | 296232 | 35921 | 79412150 |
Arthritis infective | 10.21 | 9.84 | 59 | 296258 | 8212 | 79439859 |
Cytopenia | 10.21 | 9.84 | 40 | 296277 | 20343 | 79427728 |
Device related infection | 10.19 | 9.84 | 80 | 296237 | 34214 | 79413857 |
Restlessness | 10.17 | 9.84 | 117 | 296200 | 46375 | 79401696 |
Swollen tongue | 10.16 | 9.84 | 105 | 296212 | 42465 | 79405606 |
Post procedural discharge | 10.06 | 9.84 | 13 | 296304 | 719 | 79447352 |
Complex regional pain syndrome | 10.05 | 9.84 | 23 | 296294 | 2025 | 79446046 |
Device dislocation | 10.03 | 9.84 | 56 | 296261 | 25914 | 79422157 |
Disturbance in social behaviour | 10.02 | 9.84 | 3 | 296314 | 4967 | 79443104 |
Areflexia | 10.02 | 9.84 | 4 | 296313 | 5530 | 79442541 |
Breast cancer female | 9.98 | 9.84 | 17 | 296300 | 11444 | 79436627 |
Premature delivery | 9.96 | 9.84 | 49 | 296268 | 23418 | 79424653 |
Mydriasis | 9.91 | 9.84 | 33 | 296284 | 17610 | 79430461 |
Foot fracture | 9.87 | 9.84 | 125 | 296192 | 21856 | 79426215 |
None
Source | Code | Description |
---|---|---|
ATC | R05CA03 | RESPIRATORY SYSTEM COUGH AND COLD PREPARATIONS EXPECTORANTS, EXCL. COMBINATIONS WITH COUGH SUPPRESSANTS Expectorants |
FDA PE | N0000008867 | Decreased Respiratory Secretion Viscosity |
FDA PE | N0000009560 | Increased Respiratory Secretions |
MeSH PA | D005100 | Expectorants |
MeSH PA | D019141 | Respiratory System Agents |
FDA EPC | N0000193956 | Expectorant |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Sinus headache | indication | 4969004 | |
Cough | indication | 49727002 | |
Allergic rhinitis | indication | 61582004 | |
Nasal discharge | indication | 64531003 | |
Nasal congestion | indication | 68235000 | |
Rhinitis | indication | 70076002 | DOID:4483 |
Common cold | indication | 82272006 | DOID:10459 |
Headache disorder | indication | 230461009 | |
Influenza-like symptoms | indication | 315642008 | |
Fever | indication | 386661006 | |
Asthma | off-label use | 195967001 | DOID:2841 |
Asthma-chronic obstructive pulmonary disease overlap syndrome | off-label use | 10692761000119107 | |
COPD Associated with Chronic Bronchitis | off-label use | ||
Chronic Obstructive Pulmonary Disease with Bronchospasms | off-label use | ||
Metabolic alkalosis | contraindication | 1388004 | |
Brain damage | contraindication | 2470005 | |
Anuria | contraindication | 2472002 | DOID:2983 |
Necrotizing enterocolitis in fetus OR newborn | contraindication | 2707005 | |
Ocular hypertension | contraindication | 4210003 | DOID:9282 |
Gastritis | contraindication | 4556007 | DOID:4029 |
Hypocalcemia | contraindication | 5291005 | |
Tachyarrhythmia | contraindication | 6285003 | |
Suicidal thoughts | contraindication | 6471006 | |
Dependent drug abuse | contraindication | 6525002 | |
Urinary tract obstruction | contraindication | 7163005 | DOID:5200 |
Alcoholism | contraindication | 7200002 | |
Alcohol withdrawal delirium | contraindication | 8635005 | |
Hyperammonemia | contraindication | 9360008 | |
Peptic ulcer | contraindication | 13200003 | DOID:750 |
Chronic obstructive lung disease | contraindication | 13645005 | DOID:3083 |
Asthenia | contraindication | 13791008 | |
Hepatic encephalopathy | contraindication | 13920009 | DOID:13413 |
Hyperkalemia | contraindication | 14140009 | |
Severe chronic ulcerative colitis | contraindication | 14311001 | |
Constipation | contraindication | 14760008 | DOID:2089 |
Chronic disease of respiratory system | contraindication | 17097001 | |
Mood swings | contraindication | 18963009 | |
Pulmonary edema | contraindication | 19242006 | DOID:11396 |
Cirrhosis of liver | contraindication | 19943007 | DOID:5082 |
Myocardial infarction | contraindication | 22298006 | DOID:5844 |
Glaucoma | contraindication | 23986001 | DOID:1686 |
Inflammatory bowel disease | contraindication | 24526004 | DOID:0050589 |
Ventricular tachycardia | contraindication | 25569003 | |
Alcohol intoxication | contraindication | 25702006 | |
Shock | contraindication | 27942005 | |
Toxic megacolon | contraindication | 28536002 | DOID:1770 |
Atony of colon | contraindication | 29479008 | |
Hypercapnia | contraindication | 29596007 | |
Dehydration | contraindication | 34095006 | |
Hyperthyroidism | contraindication | 34486009 | DOID:7998 |
Depressive disorder | contraindication | 35489007 | |
Acute hepatitis | contraindication | 37871000 | |
Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
Hypernatremia | contraindication | 39355002 | |
Disorder of gallbladder | contraindication | 39621005 | DOID:0060262 |
Hypothyroidism | contraindication | 40930008 | DOID:1459 |
Complete trisomy 21 syndrome | contraindication | 41040004 | DOID:14250 |
Alcoholic liver damage | contraindication | 41309000 | |
Third trimester pregnancy | contraindication | 41587001 | |
Conduction disorder of the heart | contraindication | 44808001 | |
Low blood pressure | contraindication | 45007003 | |
Achalasia of esophagus | contraindication | 45564002 | DOID:9164 |
Chronic heart failure | contraindication | 48447003 | |
Bradycardia | contraindication | 48867003 | |
Disorder of cardiovascular system | contraindication | 49601007 | DOID:1287 |
Acidosis | contraindication | 51387008 | |
Coronary arteriosclerosis | contraindication | 53741008 | DOID:3393 |
Paralytic ileus | contraindication | 55525008 | DOID:8442 |
Heart disease | contraindication | 56265001 | DOID:114 |
Peptic reflux disease | contraindication | 57643001 | |
Multiple organ failure | contraindication | 57653000 | |
Acute nephropathy | contraindication | 58574008 | |
Metabolic acidosis | contraindication | 59455009 | |
Hepatic failure | contraindication | 59927004 | |
Diarrhea | contraindication | 62315008 | |
Ulcerative colitis | contraindication | 64766004 | DOID:8577 |
Poisoning by phenobarbital | contraindication | 64921004 | |
Arterial thrombosis | contraindication | 65198009 | |
Drug AND/OR toxin-induced diarrhea | contraindication | 65979008 | |
Substance abuse | contraindication | 66214007 | |
Benign intracranial hypertension | contraindication | 68267002 | DOID:11459 |
Psychotic disorder | contraindication | 69322001 | |
Poisoning by acetaminophen | contraindication | 70273001 | |
Agoraphobia | contraindication | 70691001 | DOID:593 |
Arteriosclerotic vascular disease | contraindication | 72092001 | |
Hepatic coma | contraindication | 72836002 | DOID:12550 |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Sleep apnea | contraindication | 73430006 | DOID:0050847 |
Urethral stricture | contraindication | 76618002 | |
Spastic paralysis | contraindication | 78403003 | |
Disturbance of salivary secretion | contraindication | 78948009 | |
Decreased respiratory function | contraindication | 80954004 | |
Injury of head | contraindication | 82271004 | |
Chronic idiopathic constipation | contraindication | 82934008 | |
Oliguria | contraindication | 83128009 | |
Cor pulmonale | contraindication | 83291003 | DOID:8515 |
Hiatal hernia | contraindication | 84089009 | DOID:12642 |
Epilepsy | contraindication | 84757009 | DOID:1826 |
Pulmonary emphysema | contraindication | 87433001 | |
Kidney disease | contraindication | 90708001 | DOID:557 |
Myasthenia gravis | contraindication | 91637004 | DOID:437 |
Acute abdominal pain | contraindication | 116290004 | |
Procedure on urinary system | contraindication | 118677009 | |
Gastrointestinal obstruction | contraindication | 126765001 | |
Neoplasm of brain | contraindication | 126952004 | DOID:1319 |
Seizure disorder | contraindication | 128613002 | |
Autonomic dysreflexia | contraindication | 129618003 | |
Bleeding | contraindication | 131148009 | |
Cystic fibrosis | contraindication | 190905008 | DOID:1485 |
Drug-induced psychosis | contraindication | 191483003 | DOID:1742 |
Obsessive-compulsive disorder | contraindication | 191736004 | DOID:10933 |
Insomnia | contraindication | 193462001 | |
Angina pectoris | contraindication | 194828000 | |
Partial atrioventricular block | contraindication | 195039008 | |
Acute pancreatitis | contraindication | 197456007 | DOID:2913 |
Impaired renal function disorder | contraindication | 197663003 | |
Myocardial dysfunction | contraindication | 233928007 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Hyporeninemic hypoaldosteronism | contraindication | 236464008 | |
Bladder outflow obstruction | contraindication | 236645006 | |
Morbid obesity | contraindication | 238136002 | DOID:11981 |
Sepsis syndrome | contraindication | 238150007 | |
Rhabdomyolysis | contraindication | 240131006 | |
Pyloric obstruction | contraindication | 244815007 | |
Benign prostatic hyperplasia | contraindication | 266569009 | |
Dyspnea | contraindication | 267036007 | |
Retention of urine | contraindication | 267064002 | |
Anemia | contraindication | 271737000 | DOID:2355 |
Continuous fever | contraindication | 271751000 | |
Drowsy | contraindication | 271782001 | |
Peripheral edema | contraindication | 271809000 | |
Exacerbation of asthma | contraindication | 281239006 | |
Pregnancy, function | contraindication | 289908002 | |
Lesion of brain | contraindication | 301766008 | |
Thrombocytopenic disorder | contraindication | 302215000 | DOID:1588 |
Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
Familial hyperkalemic periodic paralysis | contraindication | 304737009 | DOID:14451 |
Panic disorder | contraindication | 371631005 | DOID:594 |
Coma | contraindication | 371632003 | |
Primary adrenocortical insufficiency | contraindication | 373662000 | |
Smoking cessation assistance | contraindication | 384742004 | |
Adrenal cortical hypofunction | contraindication | 386584007 | DOID:10493 |
Operation on gastrointestinal tract | contraindication | 386621005 | |
Hypoxia | contraindication | 389086002 | |
Angle-closure glaucoma | contraindication | 392291006 | DOID:13550 |
Pseudomembranous enterocolitis | contraindication | 397683000 | |
Gastric ulcer | contraindication | 397825006 | DOID:10808 |
Breastfeeding (mother) | contraindication | 413712001 | |
Chronic lung disease | contraindication | 413839001 | |
Chronic myocardial ischemia | contraindication | 413844008 | DOID:3393 |
Disorder of coronary artery | contraindication | 414024009 | |
Myocardial ischemia | contraindication | 414795007 | DOID:3393 |
Traumatic injury | contraindication | 417746004 | |
Myocardial infarction in recovery phase | contraindication | 418044006 | |
Central nervous system depression | contraindication | 418072004 | |
Porphyria | contraindication | 418470004 | |
Ultrarapid metabolizer due to cytochrome p450 CYP2D6 variant | contraindication | 422681000 | |
Fever greater than 100.4 Fahrenheit | contraindication | 426000000 | |
Dysfunction of sphincter of Oddi | contraindication | 430887001 | |
Hypertensive urgency | contraindication | 443482000 | |
Azotemia | contraindication | 445009001 | |
Smokes tobacco daily | contraindication | 449868002 | |
Severe dehydration | contraindication | 450316000 | |
Acute exacerbation of asthma | contraindication | 708038006 | |
Severe Hypoxemia | contraindication | ||
Theophylline Toxicity | contraindication |
None
Product | Applicant | Ingredients |
---|---|---|
Gecolate | Summit Hill Laboratories | 1 |
Gecolate, Glycodex Injection | Summit Hill Laboratories | 1 |
Guailaxin | Zoetis Inc. | 1 |
Guaifenesin Injection | Elanco US Inc. | 1 |
None
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
200MG/5ML;2.5MG/5ML | OBREDON | SOVEREIGN PHARMS | N205474 | Nov. 14, 2014 | DISCN | SOLUTION | ORAL | 10105324 | Nov. 13, 2035 | A METHOD OF INCREASING THE BIOAVAILABILITY OF GUAIFENESIN IN A SOLUTION CONTAINING 54% TO 66% BY WEIGHT OF PROPYLENE GLYCOL AND GLYCEROL, WHEREIN THE METHOD INCREASES THE CMAX BY AT LEAST 1.5 AND/OR INCREASES THE AUC (0-INF) BY AT LEAST 1.4 |
200MG/5ML;2.5MG/5ML | OBREDON | SOVEREIGN PHARMS | N205474 | Nov. 14, 2014 | DISCN | SOLUTION | ORAL | 9549907 | Nov. 13, 2035 | A METHOD OF INCREASING THE BIOAVAILABILITY OF GUAIFENESIN IN A SOLUTION CONTAINING 54% TO 66% BY WEIGHT OF PROPYLENE GLYCOL AND GLYCEROL, WHEREIN THE METHOD INCREASES THE CMAX BY AT LEAST 1.5 AND/OR INCREASES THE AUC (0-INF) BY AT LEAST 1.4 |
200MG/5ML;2.5MG/5ML | OBREDON | SOVEREIGN PHARMS | N205474 | Nov. 14, 2014 | DISCN | SOLUTION | ORAL | 9808431 | Nov. 13, 2035 | A METHOD OF INCREASING THE BIOAVAILABILITY OF GUAIFENESIN IN A SOLUTION CONTAINING 54% TO 66% BY WEIGHT OF PROPYLENE GLYCOL AND GLYCEROL, WHEREIN THE METHOD INCREASES THE CMAX BY AT LEAST 1.5 AND/OR INCREASES THE AUC (0-INF) BY AT LEAST 1.4 |
None
None
ID | Source |
---|---|
4018147 | VUID |
N0000146484 | NUI |
D00337 | KEGG_DRUG |
4018147 | VANDF |
C0018305 | UMLSCUI |
CHEBI:5551 | CHEBI |
CHEMBL980 | ChEMBL_ID |
DB00874 | DRUGBANK_ID |
D006140 | MESH_DESCRIPTOR_UI |
3516 | PUBCHEM_CID |
968 | INN_ID |
7617 | IUPHAR_LIGAND_ID |
495W7451VQ | UNII |
5032 | RXNORM |
2461 | MMSL |
4805 | MMSL |
d00797 | MMSL |
000724 | NDDF |
386184000 | SNOMEDCT_US |
87174009 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Robitussin Elderberry Maximum Strength Cough plus Chest Congestion DM | HUMAN OTC DRUG LABEL | 2 | 0031-2097 | SOLUTION | 400 mg | ORAL | OTC monograph final | 15 sections |
Childrens Robitussin Elderberry Cough and Chest Congestion DM | HUMAN OTC DRUG LABEL | 2 | 0031-2098 | SOLUTION | 400 mg | ORAL | OTC monograph final | 15 sections |
Robitussin CF | HUMAN OTC DRUG LABEL | 3 | 0031-8678 | LIQUID | 100 mg | ORAL | Export only | 15 sections |
Robitussin CF | HUMAN OTC DRUG LABEL | 3 | 0031-8678 | LIQUID | 100 mg | ORAL | Export only | 15 sections |
Childrens Robitussin Cough and Chest Congestion DM | HUMAN OTC DRUG LABEL | 2 | 0031-8702 | LIQUID | 200 mg | ORAL | OTC MONOGRAPH FINAL | 15 sections |
Childrens Robitussin Cough and Chest Congestion DM | HUMAN OTC DRUG LABEL | 2 | 0031-8702 | LIQUID | 200 mg | ORAL | OTC MONOGRAPH FINAL | 15 sections |
Childrens Robitussin Cough and Chest Congestion DM | HUMAN OTC DRUG LABEL | 2 | 0031-8715 | LIQUID | 100 mg | ORAL | OTC monograph final | 15 sections |
Childrens Robitussin Cough and Chest Congestion DM | HUMAN OTC DRUG LABEL | 2 | 0031-8715 | LIQUID | 100 mg | ORAL | OTC monograph final | 15 sections |
Childrens Robitussin Cough and Cold CF | HUMAN OTC DRUG LABEL | 3 | 0031-8716 | LIQUID | 50 mg | ORAL | OTC monograph final | 17 sections |
Childrens Robitussin Cough and Cold CF | HUMAN OTC DRUG LABEL | 3 | 0031-8716 | LIQUID | 50 mg | ORAL | OTC monograph final | 17 sections |
Childrens Robitussin Cough and Cold CF | HUMAN OTC DRUG LABEL | 3 | 0031-8716 | LIQUID | 50 mg | ORAL | OTC monograph final | 17 sections |
Robitussin Maximum Strength Cough Plus Chest Congestion DM | HUMAN OTC DRUG LABEL | 2 | 0031-8719 | CAPSULE, LIQUID FILLED | 200 mg | ORAL | OTC MONOGRAPH FINAL | 15 sections |
Robitussin Mucus Plus Chest Congestion | HUMAN OTC DRUG LABEL | 1 | 0031-8724 | LIQUID | 200 mg | ORAL | OTC MONOGRAPH FINAL | 14 sections |
ROBITUSSIN MAXIMUM STRENGTH COUGH PLUS CHEST CONGESTION DM | HUMAN OTC DRUG LABEL | 2 | 0031-8739 | SOLUTION | 400 mg | ORAL | OTC monograph final | 15 sections |
ROBITUSSIN MAXIMUM STRENGTH COUGH PLUS CHEST CONGESTION DM | HUMAN OTC DRUG LABEL | 2 | 0031-8739 | SOLUTION | 400 mg | ORAL | OTC monograph final | 15 sections |
Robitussin Peak Cold Multi-Symptom Cold | HUMAN OTC DRUG LABEL | 3 | 0031-8742 | LIQUID | 100 mg | ORAL | OTC MONOGRAPH FINAL | 17 sections |
Robitussin Peak Cold Multi-Symptom Cold | HUMAN OTC DRUG LABEL | 3 | 0031-8742 | LIQUID | 100 mg | ORAL | OTC MONOGRAPH FINAL | 17 sections |
ROBITUSSIN CHEST CONGESTION | HUMAN OTC DRUG LABEL | 1 | 0031-8748 | LIQUID | 100 mg | ORAL | EXPORT ONLY | 1 sections |
Robitussin Severe Multi-Symptom Cough Cold Flu | HUMAN OTC DRUG LABEL | 4 | 0031-8751 | LIQUID | 400 mg | ORAL | OTC monograph final | 17 sections |
Robitussin Severe Multi-Symptom Cough Cold Flu | HUMAN OTC DRUG LABEL | 4 | 0031-8751 | LIQUID | 400 mg | ORAL | OTC monograph final | 17 sections |
Robitussin Honey Maximum Strength Cough and Chest Congestion DM | HUMAN OTC DRUG LABEL | 2 | 0031-8756 | SOLUTION | 400 mg | ORAL | OTC monograph final | 15 sections |
Robitussin Honey Maximum Strength Cough and Chest Congestion DM | HUMAN OTC DRUG LABEL | 2 | 0031-8756 | SOLUTION | 400 mg | ORAL | OTC monograph final | 15 sections |
ROBITUSSIN COUGH PLUS CHEST CONGESTION DM | HUMAN OTC DRUG LABEL | 2 | 0031-8757 | SOLUTION | 200 mg | ORAL | OTC monograph final | 15 sections |
ROBITUSSIN COUGH PLUS CHEST CONGESTION DM | HUMAN OTC DRUG LABEL | 2 | 0031-8757 | SOLUTION | 200 mg | ORAL | OTC monograph final | 15 sections |
Robitussin Sugar-Free Dye-Free Cough Plus Chest Congestion DM | HUMAN OTC DRUG LABEL | 2 | 0031-8759 | SOLUTION | 200 mg | ORAL | OTC monograph final | 15 sections |
Robitussin Sugar-Free Dye-Free Cough Plus Chest Congestion DM | HUMAN OTC DRUG LABEL | 2 | 0031-8759 | SOLUTION | 200 mg | ORAL | OTC monograph final | 15 sections |
Childrens Robitussin Honey Cough and Chest Congestion DM | HUMAN OTC DRUG LABEL | 2 | 0031-8760 | SOLUTION | 100 mg | ORAL | OTC MONOGRAPH FINAL | 15 sections |
Childrens Robitussin Honey Cough and Chest Congestion DM | HUMAN OTC DRUG LABEL | 2 | 0031-8760 | SOLUTION | 100 mg | ORAL | OTC MONOGRAPH FINAL | 15 sections |
Robitussin Maximum Strength 12 Hour Cough and Mucus Relief | HUMAN OTC DRUG LABEL | 2 | 0031-8765 | TABLET, EXTENDED RELEASE | 1200 mg | ORAL | ANDA | 16 sections |
Robitussin Direct Chest Congestion | HUMAN OTC DRUG LABEL | 1 | 0031-9303 | TABLET, COATED | 400 mg | ORAL | OTC monograph final | 14 sections |