gallopamil 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| calcium channel blockers, verapamil derivatives | 1275 | 16662-47-8 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Coronary vasodilator that is an analog of iproveratril (VERAPAMIL) with one more methoxy group on the benzene ring.
|
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| Vd (Volume of distribution) | 1.75 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 14.30 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.07 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 1.80 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | C08DA02 | CARDIOVASCULAR SYSTEM CALCIUM CHANNEL BLOCKERS SELECTIVE CALCIUM CHANNEL BLOCKERS WITH DIRECT CARDIAC EFFECTS Phenylalkylamine derivatives |
| MeSH PA | D002121 | Calcium Channel Blockers |
| MeSH PA | D000077264 | Calcium-Regulating Hormones and Agents |
| MeSH PA | D002317 | Cardiovascular Agents |
| MeSH PA | D049990 | Membrane Transport Modulators |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 8.91 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Sodium channel alpha subunits; brain (Types I, II, III) | Ion channel | IC50 | 5.44 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| N0000166522 | NUI |
| D08009 | KEGG_DRUG |
| C0016986 | UMLSCUI |
| CHEBI:34772 | CHEBI |
| CHEMBL51149 | ChEMBL_ID |
| CHEMBL523367 | ChEMBL_ID |
| D005711 | MESH_DESCRIPTOR_UI |
| DB12923 | DRUGBANK_ID |
| 4318 | INN_ID |
| 16662-46-7 | SECONDARY_CAS_RN |
| 39WPC8JHR8 | UNII |
| 1234 | PUBCHEM_CID |
| 439837 | RXNORM |
| 004173 | NDDF |
| 004174 | NDDF |
| 703433005 | SNOMEDCT_US |
| 703434004 | SNOMEDCT_US |
Pharmaceutical products:
None