gabapentin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
gabamimetic agents 1264 60142-96-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • gabapentin
  • gabamox
  • gabapen
  • neurontin
  • gabapentine
The mechanism by which gabapentin exerts its analgesic action is unknown, but in animal models of analgesia, gabapentin prevents allodynia (pain-related behavior in response to a normally innocuous stimulus) and hyperalgesia (exaggerated response to painful stimuli). In particular, gabapentin prevents pain-related responses in several models of neuropathic pain in rats or mice (e.g., spinal nerve ligation models, streptozocin-induced diabetes model, spinal cord injury model, acute herpes zoster infection model). Gabapentin also decreases pain-related responses after peripheral inflammation (carrageenan footpad test, late phase of formalin test). Gabapentin did not alter immediate pain-related behaviors (rat tail flick test, formalin footpad acute phase, acetic acid abdominal constriction test, footpad heat irradiation test). The mechanism by which gabapentin exerts its anticonvulsant action is unknown, but in animal test systems designed to detect anticonvulsant activity, gabapentin prevents seizures as do other marketed anticonvulsants. Gabapentin exhibits antiseizure activity in mice and rats in both the maximal electroshock and pentylenetetrazole seizure models and other preclinical models (e.g., strains with genetic epilepsy, etc.). Gabapentin is structurally related to the neurotransmitter GABA (gamma-aminobutyric acid) but it does not modify GABAA or GABAB radioligand binding, it is not converted metabolically into GABA or a GABA agonist, and it is not an inhibitor of GABA uptake or degradation. Gabapentin was tested in radioligand binding assays at concentrations up to 100 uM and did not exhibit affinity for a number of other common receptor sites, including benzodiazepine, glutamate, N-methyl-D-aspartate (NMDA), quisqualate, kainate, strychnine-insensitive or strychnine-sensitive glycine, alpha 1, alpha 2, or beta adrenergic, adenosine A1 or A2, cholinergic muscarinic or nicotinic, dopamine D1 or D2, histamine H1, serotonin S1 or S2, opiate mu, delta or kappa, cannabinoid 1, voltage-sensitive calcium channel sites labeled with nitrendipine or diltiazem, or at voltage-sensitive sodium channel sites labeled with batrachotoxinin A 20-alpha-benzoate. Furthermore, gabapentin did not alter the cellular uptake of dopamine, noradrenaline, or serotonin. In vitro studies with radiolabeled gabapentin have revealed a gabapentin binding site in areas of rat brain including neocortex and hippocampus. A high-affinity binding protein in animal brain tissue has been identified as an auxiliary subunit of voltage-activated calcium channels.
  • Molecular weight: 171.24
  • Formula: C9H17NO2
  • CLOGP: -0.66
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 2
  • TPSA: 63.32
  • ALOGS: -1.60
  • ROTB: 3
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
1.80 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 10 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 100 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 116.79 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 60 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.71 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1.70 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.97 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 5.30 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AXL,BRAF,BTK,CAMK2D,CDK4,CDK5,CDK9,DYRK1B,EGFR,EIF2AK3,ERBB2,GRK2,IKBKB,ITK,JAK3,MAP2K6,MAPK10,MAPK7,MAPKAPK2,NTRK1,NTRK2,PDK2,PDK4,PRKDC,SIK2,STK33,SYK,TEK,TGFBR1,ZAP70 32
kinase-selectivity-class AXL,BRAF,CDK4,EIF2AK3,EPHB4,MAP2K6,STK33,TEK 8
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 0.555 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
rat-kpuu-brain Rat brain Kpuu 0.032 % High 1

Approvals:

DateAgencyCompanyOrphan
Dec. 30, 1993 FDA PFIZER PHARMS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 2075.66 9.48 3012 436943 142046 90046446
Pemphigus 1518.97 9.48 12 439943 326852 89861640
Glossodynia 1226.31 9.48 87 439868 321692 89866800
Hand deformity 1199.84 9.48 57 439898 296305 89892187
Drug hypersensitivity 1178.11 9.48 4909 435046 458700 89729792
Systemic lupus erythematosus 1169.56 9.48 180 439775 361716 89826776
Anti-cyclic citrullinated peptide antibody positive 1101.51 9.48 8 439947 236425 89952067
Pericarditis 1058.97 9.48 63 439892 270088 89918404
Duodenal ulcer perforation 1043.69 9.48 5 439950 221283 89967209
Helicobacter infection 979.16 9.48 26 439929 226824 89961668
Synovitis 978.74 9.48 204 439751 329548 89858944
Drug ineffective for unapproved indication 864.96 9.48 1323 438632 65321 90123171
Folliculitis 802.72 9.48 47 439908 204306 89984186
Wound 793.81 9.48 242 439713 302738 89885754
Muscle injury 766.98 9.48 19 439936 176635 90011857
Rheumatoid factor positive 762.83 9.48 14 439941 171636 90016856
Maternal exposure during pregnancy 729.62 9.48 421 439534 359642 89828850
Toxicity to various agents 713.24 9.48 3027 436928 284819 89903673
Arthropathy 695.29 9.48 462 439493 365780 89822712
Somnolence 669.68 9.48 2385 437570 206699 89981793
Rheumatic fever 651.61 9.48 20 439935 153101 90035391
Multiple sclerosis relapse 610.27 9.48 989 438966 51316 90137176
Irritable bowel syndrome 583.83 9.48 144 439811 207304 89981188
Liver injury 583.27 9.48 71 439884 170496 90017996
Fall 559.70 9.48 4128 435827 477682 89710810
General physical health deterioration 549.43 9.48 548 439407 354567 89833925
Impaired healing 546.75 9.48 226 439729 233973 89954519
Sleep disorder due to general medical condition, insomnia type 526.21 9.48 23 439932 128671 90059821
Swollen joint count increased 521.60 9.48 3 439952 111203 90077289
Contraindicated product administered 506.80 9.48 484 439471 319655 89868837
Infusion related reaction 492.05 9.48 790 439165 415990 89772502
Type 2 diabetes mellitus 489.36 9.48 187 439768 203057 89985435
Drug abuse 469.81 9.48 1154 438801 81193 90107299
Discomfort 458.91 9.48 394 439561 273941 89914551
Myoclonus 447.49 9.48 508 439447 18660 90169832
Swelling 439.78 9.48 855 439100 418203 89770289
C-reactive protein abnormal 438.21 9.48 52 439903 127377 90061115
Lower respiratory tract infection 430.31 9.48 351 439604 250308 89938184
Suicidal ideation 408.63 9.48 1023 438932 72832 90115660
Hepatic enzyme increased 406.90 9.48 704 439251 360032 89828460
Abdominal discomfort 405.34 9.48 1092 438863 476236 89712256
Feeling abnormal 403.12 9.48 1745 438210 165490 90023002
Breast cancer stage III 387.62 9.48 4 439951 84443 90104049
Tremor 382.07 9.48 1615 438340 151558 90036934
Blister 380.06 9.48 406 439549 254592 89933900
Multiple sclerosis 361.51 9.48 553 439402 27287 90161205
Ill-defined disorder 360.38 9.48 226 439729 184665 90003827
Facet joint syndrome 359.36 9.48 32 439923 98357 90090135
Alopecia 359.12 9.48 1218 438737 493853 89694639
C-reactive protein increased 350.41 9.48 224 439731 181165 90007327
Hypercholesterolaemia 344.84 9.48 42 439913 100850 90087642
Product dose omission issue 344.21 9.48 2510 437445 289177 89899315
Lip dry 340.25 9.48 44 439911 100911 90087581
Blood cholesterol increased 339.02 9.48 306 439649 207706 89980786
Therapeutic product effect decreased 337.92 9.48 515 439440 277056 89911436
Joint swelling 333.44 9.48 1286 438669 502014 89686478
Psoriatic arthropathy 311.66 9.48 390 439565 227945 89960547
Injury 306.72 9.48 303 439652 197046 89991446
Stomatitis 300.67 9.48 546 439409 274152 89914340
Respiratory arrest 279.05 9.48 545 439410 32766 90155726
Hallucination 265.02 9.48 813 439142 65146 90123346
Peripheral venous disease 259.04 9.48 47 439908 83874 90104618
Live birth 258.26 9.48 38 439917 79069 90109423
Joint range of motion decreased 254.51 9.48 173 439782 135470 90053022
Wound infection 252.53 9.48 100 439855 106302 90082190
Cardio-respiratory arrest 249.73 9.48 774 439181 62366 90126126
Wheezing 247.51 9.48 488 439467 237592 89950900
Pulmonary fibrosis 247.11 9.48 106 439849 107397 90081095
Back pain 246.20 9.48 2487 437468 314688 89873804
Neuropathy peripheral 245.09 9.48 1312 438643 135658 90052834
Balance disorder 243.06 9.48 1025 438930 96055 90092437
Seizure 241.27 9.48 1414 438541 151215 90037277
Dislocation of vertebra 235.57 9.48 8 439947 55960 90132532
Adjustment disorder with depressed mood 229.16 9.48 11 439944 56742 90131750
Drug withdrawal syndrome 227.43 9.48 459 439496 28264 90160228
Grip strength decreased 226.37 9.48 83 439872 92493 90095999
Vision blurred 226.36 9.48 1098 438857 109195 90079297
Withdrawal syndrome 225.64 9.48 398 439557 22126 90166366
Neuralgia 223.25 9.48 481 439474 31019 90157473
Urinary tract infection 217.59 9.48 2355 437600 303277 89885215
Bone erosion 214.98 9.48 10 439945 53011 90135481
Mental status changes 212.49 9.48 585 439370 44094 90144398
Hypersensitivity 210.54 9.48 1318 438637 453359 89735133
Depression 209.73 9.48 2307 437648 298294 89890198
Gastrointestinal disorder 205.87 9.48 603 439352 256084 89932408
Dizziness 204.12 9.48 4003 435952 585281 89603211
Mobility decreased 202.56 9.48 587 439368 250147 89938345
Hyperhidrosis 197.74 9.48 1235 438720 135070 90053422
Intentional product misuse 197.69 9.48 911 439044 88693 90099799
Accidental death 193.84 9.48 122 439833 1926 90186566
Blepharospasm 192.13 9.48 22 439933 55423 90133069
X-ray abnormal 189.41 9.48 7 439948 45417 90143075
Autoimmune disorder 185.63 9.48 70 439885 76674 90111818
Overdose 174.94 9.48 1338 438617 156371 90032121
Retinitis 171.34 9.48 3 439952 38455 90150037
Cardiac arrest 170.22 9.48 979 438976 103956 90084536
Death 167.70 9.48 3130 436825 453421 89735071
Myelosuppression 167.59 9.48 29 439926 53562 90134930
Night sweats 167.32 9.48 228 439727 128538 90059954
Suspected suicide 167.09 9.48 219 439736 9349 90179143
Inflammation 166.48 9.48 389 439566 178203 90010289
Sopor 166.33 9.48 369 439586 24275 90164217
Drug dependence 166.12 9.48 410 439545 28917 90159575
Respiratory depression 164.86 9.48 282 439673 15293 90173199
Onychomadesis 160.02 9.48 18 439937 45980 90142512
Lung disorder 156.76 9.48 306 439649 149577 90038915
Intentional product use issue 155.31 9.48 536 439419 216356 89972136
Dyskinesia 152.06 9.48 456 439499 36078 90152414
Anxiety 149.50 9.48 2221 437734 307551 89880941
Obesity 147.24 9.48 177 439778 105330 90083162
Drug-induced liver injury 146.90 9.48 133 439822 90185 90098307
Product complaint 146.29 9.48 247 439708 13253 90175239
Drug intolerance 145.63 9.48 1429 438526 446162 89742330
Lupus-like syndrome 145.15 9.48 30 439925 48816 90139676
Lethargy 140.04 9.48 643 439312 62496 90125996
Breast cancer stage II 139.04 9.48 8 439947 35326 90153166
Fibromyalgia 138.90 9.48 523 439432 205746 89982746
Nasopharyngitis 136.54 9.48 1290 438665 405814 89782678
Treatment failure 134.92 9.48 892 439063 303036 89885456
Nail disorder 134.52 9.48 59 439896 59008 90129484
Unresponsive to stimuli 133.22 9.48 448 439507 37673 90150819
Sinusitis 130.15 9.48 1053 438902 342035 89846457
Urticaria 127.93 9.48 940 439015 311794 89876698
Hip arthroplasty 125.40 9.48 111 439844 76097 90112395
Mental disorder 122.09 9.48 390 439565 31928 90156564
Plasma cell myeloma 115.62 9.48 448 439507 40380 90148112
Pain in extremity 113.66 9.48 2927 437028 447602 89740890
Speech disorder 113.03 9.48 480 439475 45105 90143387
Sedation 110.12 9.48 495 439460 47676 90140816
Head injury 109.41 9.48 367 439588 30821 90157671
Infection 108.29 9.48 1179 438776 360915 89827577
Vertigo 107.17 9.48 642 439313 69169 90119323
Burning sensation 106.17 9.48 597 439358 62855 90125637
Sleep apnoea syndrome 103.87 9.48 365 439590 31382 90157110
Oedema 103.54 9.48 560 439395 199735 89988757
Food allergy 103.20 9.48 315 439640 25163 90163329
Pyrexia 102.78 9.48 2432 437523 658053 89530439
Pregnancy 101.34 9.48 91 439864 61956 90126536
Lower limb fracture 101.16 9.48 160 439795 84853 90103639
Surgery 100.92 9.48 459 439496 44428 90144064
Depressed level of consciousness 100.26 9.48 651 439304 72133 90116359
Constipation 99.91 9.48 1914 438041 278481 89910011
Hepatic cirrhosis 99.49 9.48 96 439859 63157 90125335
Liver function test increased 98.81 9.48 162 439793 84693 90103799
Disturbance in attention 98.77 9.48 472 439483 46637 90141855
Gait disturbance 97.93 9.48 1793 438162 258703 89929789
Hypersomnia 96.55 9.48 276 439679 21255 90167237
Sleep disorder 96.22 9.48 565 439390 197465 89991027
Exposure during pregnancy 95.83 9.48 720 439235 237690 89950802
Musculoskeletal stiffness 95.39 9.48 949 439006 295583 89892909
Urinary incontinence 95.04 9.48 398 439557 37168 90151324
Prescribed underdose 94.28 9.48 136 439819 74883 90113609
Onychomycosis 93.94 9.48 32 439923 37344 90151148
Knee arthroplasty 93.91 9.48 162 439793 83020 90105472
Drug tolerance decreased 90.91 9.48 22 439933 32108 90156384
Red blood cell sedimentation rate increased 90.41 9.48 164 439791 82431 90106061
Taste disorder 89.37 9.48 100 439855 61446 90127046
Product use issue 88.62 9.48 1100 438855 328819 89859673
Liver disorder 88.59 9.48 297 439658 120972 90067520
Nausea 88.48 9.48 6389 433566 1103927 89084565
Hallucination, visual 88.44 9.48 280 439675 22812 90165680
Drug use disorder 88.22 9.48 151 439804 8192 90180300
Agitation 87.50 9.48 592 439363 66506 90121986
Muscle twitching 86.85 9.48 287 439668 23915 90164577
Therapeutic response unexpected 86.28 9.48 268 439687 21612 90166880
Encephalopathy 85.82 9.48 449 439506 45995 90142497
Trigeminal neuralgia 85.60 9.48 103 439852 4028 90184464
Crying 84.89 9.48 296 439659 25349 90163143
Febrile neutropenia 84.46 9.48 438 439517 157911 90030581
Device expulsion 83.80 9.48 47 439908 40839 90147653
Intervertebral disc protrusion 83.28 9.48 306 439649 26890 90161602
Macular degeneration 83.24 9.48 40 439915 37930 90150562
Bursitis 82.13 9.48 344 439611 131310 90057182
Full blood count decreased 81.81 9.48 323 439632 29366 90159126
Dyspepsia 81.75 9.48 594 439361 197566 89990926
Inadequate analgesia 81.35 9.48 89 439866 3135 90185357
Diplopia 81.24 9.48 315 439640 28399 90160093
Epilepsy 80.69 9.48 174 439781 82032 90106460
Coma 79.80 9.48 615 439340 72017 90116475
Nervousness 78.62 9.48 351 439604 33705 90154787
Laryngitis 77.56 9.48 79 439876 50674 90137818
Temperature regulation disorder 77.52 9.48 199 439756 14380 90174112
Fatigue 77.04 9.48 6550 433405 1147473 89041019
Rash 76.63 9.48 3124 436831 792976 89395516
Nightmare 75.63 9.48 255 439700 21470 90167022
Loss of consciousness 74.94 9.48 1024 438931 139214 90049278
Rheumatoid arthritis 74.66 9.48 1274 438681 361340 89827152
Adverse event 74.36 9.48 305 439650 117113 90071379
Restless legs syndrome 73.21 9.48 258 439697 22212 90166280
Sciatica 72.21 9.48 251 439704 101131 90087361
Cytomegalovirus infection 71.85 9.48 20 439935 26582 90161910
Headache 71.25 9.48 4980 434975 857766 89330726
Feeling drunk 71.12 9.48 101 439854 4657 90183835
Influenza like illness 70.73 9.48 649 439306 79962 90108530
Product label confusion 70.07 9.48 13 439942 22837 90165655
Limb injury 69.94 9.48 321 439634 31187 90157305
Joint injury 69.00 9.48 328 439627 32336 90156156
Irritability 68.83 9.48 349 439606 35313 90153179
Disorientation 68.54 9.48 407 439548 43707 90144785
Euphoric mood 68.19 9.48 106 439849 5303 90183189
Cerebrovascular accident 68.05 9.48 907 439048 122626 90065866
Spinal operation 68.05 9.48 152 439803 10044 90178448
Mood altered 67.61 9.48 210 439745 16934 90171558
Dysstasia 66.98 9.48 270 439685 24782 90163710
Foot deformity 66.58 9.48 117 439838 59534 90128958
Maternal exposure timing unspecified 66.40 9.48 14 439941 22469 90166023
Ankle fracture 65.60 9.48 233 439722 20137 90168355
Muscle spasms 64.73 9.48 1641 438314 250242 89938250
Foetal death 64.16 9.48 234 439721 20489 90168003
Prescription drug used without a prescription 63.95 9.48 79 439876 3176 90185316
Interstitial lung disease 63.75 9.48 176 439779 76229 90112263
Illness 63.08 9.48 642 439313 81327 90107165
Stress 62.40 9.48 637 439318 80758 90107734
Ataxia 62.12 9.48 211 439744 17831 90170661
Hepatic function abnormal 62.11 9.48 80 439875 46208 90142284
Hyperaesthesia 62.07 9.48 151 439804 10551 90177941
Serotonin syndrome 61.75 9.48 354 439601 37533 90150959
Pleural fibrosis 60.77 9.48 81 439874 3515 90184977
Herpes zoster 60.74 9.48 715 439240 93929 90094563
Anger 60.67 9.48 175 439780 13545 90174947
Poisoning 60.57 9.48 187 439768 15030 90173462
Paradoxical drug reaction 60.50 9.48 104 439851 5662 90182830
Thrombosis 60.39 9.48 582 439373 72669 90115823
Road traffic accident 59.48 9.48 294 439661 107332 90081160
Osteoarthritis 58.97 9.48 636 439319 195094 89993398
Product administration interrupted 58.82 9.48 163 439792 12329 90176163
Urinary retention 58.49 9.48 348 439607 37396 90151096
Presbyacusis 58.43 9.48 73 439882 2969 90185523
Frequent bowel movements 57.99 9.48 118 439837 56817 90131675
Colitis ulcerative 57.14 9.48 130 439825 60136 90128356
Suicide attempt 56.81 9.48 588 439367 74811 90113681
Chronic obstructive pulmonary disease 56.22 9.48 577 439378 73252 90115240
Anticipatory anxiety 55.85 9.48 47 439908 1186 90187306
Concussion 55.51 9.48 148 439807 10943 90177549
Accidental overdose 55.49 9.48 278 439677 27995 90160497
Impaired driving ability 55.19 9.48 94 439861 5079 90183413
Blood potassium decreased 54.60 9.48 408 439547 47319 90141173
Depressed mood 54.47 9.48 424 439531 49798 90138694
Premature baby 54.08 9.48 27 439928 25050 90163442
Pustular psoriasis 53.90 9.48 12 439943 18544 90169948
Pre-existing condition improved 53.85 9.48 130 439825 9039 90179453
Normal newborn 53.72 9.48 23 439932 23339 90165153
Blood magnesium increased 53.40 9.48 74 439881 3334 90185158
Pleural thickening 53.12 9.48 72 439883 3176 90185316
Tardive dyskinesia 52.84 9.48 144 439811 10786 90177706
Muscle tightness 52.43 9.48 164 439791 13275 90175217
Asterixis 52.36 9.48 52 439903 1633 90186859
Myocardial infarction 52.27 9.48 763 439192 105209 90083283
Drug screen positive 52.14 9.48 77 439878 3680 90184812
Neovascularisation 51.95 9.48 51 439904 1579 90186913
Rash erythematous 51.58 9.48 513 439442 64591 90123901
Dysarthria 51.58 9.48 446 439509 54036 90134456
Limb discomfort 51.54 9.48 339 439616 37721 90150771
Drug interaction 51.51 9.48 1730 438225 274723 89913769
Cellulitis 50.87 9.48 672 439283 90665 90097827
Fluid retention 50.69 9.48 652 439303 87439 90101053
Back injury 50.63 9.48 93 439862 46529 90141963
Body height decreased 50.53 9.48 150 439805 11799 90176693
Gait inability 50.32 9.48 461 439494 145995 90042497
White blood cell count decreased 49.70 9.48 1111 438844 165998 90022494
Panic attack 49.48 9.48 256 439699 26109 90162383
Nerve injury 49.44 9.48 142 439813 10964 90177528
Intervertebral disc degeneration 49.27 9.48 190 439765 17084 90171408
Joint dislocation 49.25 9.48 88 439867 44494 90143998
Tinnitus 49.04 9.48 368 439587 42734 90145758
Cognitive disorder 47.97 9.48 532 439423 68875 90119617
Nerve compression 47.92 9.48 136 439819 10430 90178062
Therapy interrupted 47.85 9.48 411 439544 49697 90138795
Hepatitis 47.81 9.48 179 439776 70560 90117932
Rheumatoid nodule 47.75 9.48 19 439936 20147 90168345
Dysphagia 46.85 9.48 786 439169 111492 90077000
Intentional overdose 46.83 9.48 677 439278 93157 90095335
COVID-19 46.65 9.48 1111 438844 167732 90020760
Mental impairment 46.14 9.48 182 439773 16538 90171954
Dysphemia 45.64 9.48 65 439890 3005 90185487
Cyst 45.49 9.48 180 439775 16381 90172111
Red blood cell sedimentation rate abnormal 45.20 9.48 31 439924 24173 90164319
Complex regional pain syndrome 45.10 9.48 60 439895 2599 90185893
Brain injury 44.69 9.48 109 439846 7629 90180863
Foetal exposure during pregnancy 44.68 9.48 88 439867 42887 90145605
Therapy cessation 44.56 9.48 316 439639 36045 90152447
Hypermobility syndrome 44.51 9.48 36 439919 858 90187634
Chorea 44.36 9.48 53 439902 2057 90186435
Hepatotoxicity 44.18 9.48 98 439857 45744 90142748
Musculoskeletal pain 44.06 9.48 576 439379 170675 90017817
Malignant neoplasm progression 43.74 9.48 321 439634 106549 90081943
Ulcer haemorrhage 43.70 9.48 38 439917 26283 90162209
Therapy non-responder 43.70 9.48 438 439517 136266 90052226
Dehydration 43.69 9.48 1245 438710 193202 89995290
Immunodeficiency 43.08 9.48 358 439597 42876 90145616
Epigastric discomfort 43.06 9.48 106 439849 7462 90181030
Foot fracture 42.97 9.48 248 439707 26358 90162134
Myoclonic epilepsy 42.95 9.48 46 439909 1581 90186911
Drug resistance 42.55 9.48 51 439904 30398 90158094
Hot flush 42.50 9.48 459 439496 59029 90129463
Incoherent 42.37 9.48 82 439873 4895 90183597
Diarrhoea 42.33 9.48 5191 434764 933999 89254493
Proctitis 42.10 9.48 11 439944 15248 90173244
Thinking abnormal 41.98 9.48 139 439816 11593 90176899
Joint destruction 41.96 9.48 7 439948 13280 90175212
Bradyphrenia 41.61 9.48 105 439850 7507 90180985
Memory impairment 41.34 9.48 1252 438703 195992 89992500
Condition aggravated 41.08 9.48 2419 437536 593126 89595366
Diabetic neuropathy 40.96 9.48 77 439878 4497 90183995
Dry eye 40.94 9.48 446 439509 57485 90131007
Lymphoedema 40.65 9.48 153 439802 13600 90174892
Paranoia 40.17 9.48 146 439809 12762 90175730
Flushing 40.10 9.48 628 439327 87863 90100629
Psychomotor hyperactivity 39.93 9.48 145 439810 12668 90175824
Central nervous system lesion 39.92 9.48 136 439819 11510 90176982
Peroneal nerve palsy 39.84 9.48 87 439868 5661 90182831
Peripheral swelling 39.41 9.48 1622 438333 411484 89777008
Pancytopenia 39.41 9.48 383 439572 119880 90068612
Tooth loss 39.02 9.48 102 439853 7452 90181040
Infusion site reaction 38.85 9.48 22 439933 19017 90169475
Coordination abnormal 38.45 9.48 205 439750 21151 90167341
Mucosal inflammation 38.18 9.48 147 439808 57478 90131014
Dissociation 38.15 9.48 94 439861 6621 90181871
Influenza 37.44 9.48 913 439042 138351 90050141
Carpal tunnel syndrome 37.32 9.48 221 439734 23707 90164785
Pollakiuria 37.10 9.48 281 439674 32724 90155768
Thrombotic microangiopathy 37.01 9.48 15 439940 15728 90172764
Ligament sprain 36.40 9.48 154 439801 14445 90174047
Pneumocystis jirovecii pneumonia 36.14 9.48 31 439924 21585 90166907
Stiff person syndrome 36.00 9.48 25 439930 469 90188023
Myocardial stunning 35.67 9.48 21 439934 292 90188200
Congenital absence of vertebra 35.53 9.48 12 439943 36 90188456
Somatic delusion 35.48 9.48 27 439928 587 90187905
Bronchitis 35.42 9.48 983 438972 151944 90036548
Osteoporosis 35.29 9.48 299 439656 96232 90092260
Hypertension 35.29 9.48 1838 438117 455694 89732798
Granuloma skin 35.15 9.48 5 439950 10675 90177817
Injection site mass 35.08 9.48 205 439750 21885 90166607
Underdose 35.02 9.48 139 439816 53878 90134614
Hypokinesia 34.90 9.48 160 439795 15537 90172955
Focal dyscognitive seizures 34.70 9.48 58 439897 3086 90185406
Exposure via ingestion 34.65 9.48 53 439902 2614 90185878
Disability 34.63 9.48 93 439862 40652 90147840
Therapeutic response decreased 34.60 9.48 274 439681 89455 90099037
Bipolar disorder 34.45 9.48 109 439846 8876 90179616
Chronic sinusitis 34.20 9.48 39 439916 23763 90164729
Drug diversion 33.82 9.48 33 439922 1014 90187478
Intentional self-injury 33.68 9.48 251 439704 29083 90159409
Panniculitis 33.62 9.48 14 439941 14444 90174048
Visual snow syndrome 33.51 9.48 12 439943 45 90188447
Hyperreflexia 33.48 9.48 89 439866 6568 90181924
Kidney infection 33.39 9.48 228 439727 25688 90162804
Substance abuse 33.21 9.48 78 439877 5328 90183164
Generalised tonic-clonic seizure 33.18 9.48 286 439669 34617 90153875
Oesophageal spasm 33.16 9.48 59 439896 3302 90185190
Exostosis 33.02 9.48 139 439816 52995 90135497
Pituitary tumour benign 32.97 9.48 46 439909 2086 90186406
Deafness neurosensory 32.94 9.48 90 439865 6751 90181741
Metabolic encephalopathy 32.68 9.48 89 439866 6663 90181829
Injection site pain 32.59 9.48 1088 438867 172611 90015881
Rib fracture 32.54 9.48 230 439725 26205 90162287
Vaginal discharge 32.44 9.48 28 439927 19436 90169056
Micturition urgency 32.41 9.48 124 439831 11109 90177383
Accidental poisoning 32.40 9.48 31 439924 929 90187563
Polyarthritis 32.32 9.48 25 439930 18325 90170167
Dental caries 32.22 9.48 125 439830 11272 90177220
Somatic symptom disorder 32.16 9.48 59 439896 3382 90185110
Spinal osteoarthritis 31.92 9.48 180 439775 18968 90169524
Cardiac failure congestive 31.85 9.48 664 439291 98030 90090462
Contusion 31.84 9.48 952 439003 250264 89938228
Transient ischaemic attack 31.71 9.48 335 439620 42841 90145651
Cystitis 31.57 9.48 477 439478 66241 90122251
Nervous system disorder 31.50 9.48 196 439759 21397 90167095
Eosinophilic colitis 31.49 9.48 18 439937 236 90188256
Multiple organ dysfunction syndrome 31.06 9.48 199 439756 68137 90120355
Arteriovenous malformation 30.97 9.48 38 439917 1517 90186975
Sensory disturbance 30.56 9.48 152 439803 15261 90173231
Bone cyst 30.53 9.48 47 439908 2331 90186161
Persistent depressive disorder 30.51 9.48 34 439921 1223 90187269
Hip fracture 30.38 9.48 269 439686 32808 90155684
Gastrointestinal motility disorder 30.20 9.48 81 439874 6010 90182482
Seasonal allergy 30.09 9.48 203 439752 22780 90165712
Anal incontinence 30.04 9.48 157 439798 16073 90172419
Incorrect route of product administration 29.90 9.48 135 439820 50491 90138001
Therapeutic product effect incomplete 29.74 9.48 715 439240 193181 89995311
Diabetes mellitus 29.62 9.48 461 439494 64414 90124078
Burns second degree 29.55 9.48 42 439913 1938 90186554
Asthenia 29.28 9.48 2989 436966 530762 89657730
Drug screen false positive 29.12 9.48 29 439926 914 90187578
Somnambulism 29.06 9.48 81 439874 6147 90182345
Facial pain 29.04 9.48 134 439821 13048 90175444
Spinal disorder 28.96 9.48 123 439832 11556 90176936
Pulmonary toxicity 28.76 9.48 10 439945 11521 90176971
Unevaluable event 28.67 9.48 399 439556 54449 90134043
Bone marrow failure 28.56 9.48 72 439883 32149 90156343
Abnormal behaviour 28.51 9.48 198 439757 22430 90166062
Cervical spinal stenosis 28.27 9.48 48 439907 2587 90185905
Movement disorder 28.22 9.48 239 439716 28780 90159712
Congenital thrombocytopenia 28.22 9.48 11 439944 55 90188437
Intentional dose omission 27.58 9.48 164 439791 17619 90170873
Decreased interest 27.53 9.48 64 439891 4343 90184149
Overweight 27.52 9.48 77 439878 5857 90182635
Arthralgia 27.43 9.48 3335 436620 775187 89413305
Human epidermal growth factor receptor decreased 27.39 9.48 8 439947 12 90188480
Secondary progressive multiple sclerosis 27.35 9.48 36 439919 1543 90186949
Finger deformity 27.27 9.48 76 439879 32821 90155671
Paranasal cyst 27.04 9.48 26 439929 784 90187708
Skin lesion 27.01 9.48 289 439666 37076 90151416
Respiratory failure 26.81 9.48 759 439196 117659 90070833
Vascular malformation 26.75 9.48 25 439930 727 90187765
Eye injury 26.73 9.48 10 439945 11010 90177482
Ageusia 26.71 9.48 151 439804 15925 90172567
Paraesthesia 26.64 9.48 1478 438477 248848 89939644
JC polyomavirus test positive 26.56 9.48 38 439917 1764 90186728
Decreased immune responsiveness 26.42 9.48 98 439857 8650 90179842
Anorgasmia 26.31 9.48 24 439931 676 90187816
Drug abuser 26.25 9.48 47 439908 2643 90185849
Post procedural infection 26.21 9.48 115 439840 10959 90177533
Blood lactate dehydrogenase increased 26.19 9.48 54 439901 25878 90162614
Insomnia 26.18 9.48 1918 438037 331556 89856936
Syncope 26.18 9.48 836 439119 131827 90056665
Female genital tract fistula 25.97 9.48 29 439926 17839 90170653
Slow speech 25.94 9.48 39 439916 1894 90186598
Abdominal pain upper 25.89 9.48 1335 438620 331339 89857153
Drug titration error 25.89 9.48 31 439924 1206 90187286
Pleural effusion 25.83 9.48 385 439570 111606 90076886
Medication overuse headache 25.66 9.48 34 439921 1467 90187025
Premature delivery 25.60 9.48 99 439856 38663 90149829
Pain in jaw 25.46 9.48 350 439605 47635 90140857
Cardiac failure 25.40 9.48 376 439579 109120 90079372
Neck pain 25.40 9.48 729 439226 113234 90075258
Acute respiratory failure 25.25 9.48 319 439636 42599 90145893
Abnormal dreams 25.22 9.48 115 439840 11142 90177350
Hallucination, auditory 25.21 9.48 148 439807 15827 90172665
Premature labour 25.15 9.48 17 439938 13359 90175133
Hypopnoea 25.15 9.48 62 439893 4369 90184123
Aggression 25.07 9.48 218 439737 26450 90162042
Palpitations 25.02 9.48 854 439101 135874 90052618
Product dose omission in error 25.01 9.48 178 439777 20325 90168167
Respiratory disorder 24.95 9.48 198 439757 64618 90123874
Bladder disorder 24.84 9.48 111 439844 10661 90177831
Rib deformity 24.81 9.48 16 439939 264 90188228
Paralysis 24.78 9.48 116 439839 11362 90177130
Electrocardiogram QRS complex prolonged 24.48 9.48 85 439870 7263 90181229
Cardiac disorder 24.41 9.48 400 439555 56472 90132020
Delusion 24.34 9.48 132 439823 13708 90174784
Spinal stenosis 24.08 9.48 156 439799 17268 90171224
Formication 24.04 9.48 64 439891 4727 90183765
Spinal fracture 23.94 9.48 186 439769 21830 90166662
Diffuse axonal injury 23.92 9.48 11 439944 88 90188404
Walking aid user 23.89 9.48 90 439865 35416 90153076
Psoriasis 23.89 9.48 910 439045 146844 90041648
Spinal flattening 23.85 9.48 16 439939 283 90188209
Hostility 23.85 9.48 41 439914 2232 90186260
Impaired quality of life 23.78 9.48 193 439762 22951 90165541
Blood parathyroid hormone decreased 23.69 9.48 15 439940 12201 90176291
Autonomic nervous system imbalance 23.66 9.48 52 439903 3398 90185094
Post procedural complication 23.63 9.48 166 439789 18876 90169616
Sepsis 23.52 9.48 1083 438872 178731 90009761
Blood potassium increased 23.52 9.48 177 439778 20572 90167920
Psychotic disorder due to a general medical condition 23.50 9.48 15 439940 243 90188249
Pulmonary aplasia 23.40 9.48 7 439948 12 90188480
Weight increased 23.28 9.48 1730 438225 416197 89772295
Tooth disorder 23.20 9.48 242 439713 30848 90157644
Impaired gastric emptying 23.09 9.48 123 439832 12686 90175806
Skin necrosis 23.02 9.48 29 439926 16912 90171580
Jaundice cholestatic 22.91 9.48 10 439945 10033 90178459
Osteopenia 22.66 9.48 190 439765 22812 90165680
Localised infection 22.62 9.48 256 439699 33306 90155186
Blood glucose increased 22.54 9.48 614 439341 94632 90093860
Ear infection 22.52 9.48 223 439732 69552 90118940
Disorganised speech 22.46 9.48 36 439919 1849 90186643
Hypoxia 22.36 9.48 484 439471 71915 90116577
Alcoholism 22.31 9.48 35 439920 1765 90186727
Facial spasm 22.18 9.48 23 439932 761 90187731
Haematotoxicity 22.18 9.48 17 439938 12518 90175974
Communication disorder 22.15 9.48 49 439906 3217 90185275
Joint stiffness 22.14 9.48 257 439698 77785 90110707
Injection site induration 22.02 9.48 105 439850 10363 90178129
Increased tendency to bruise 22.00 9.48 115 439840 11775 90176717
Heart rate increased 21.89 9.48 710 439245 112192 90076300
Cytomegalovirus viraemia 21.84 9.48 5 439950 7581 90180911
Pharyngeal swelling 21.84 9.48 101 439854 9843 90178649
Nephrogenic systemic fibrosis 21.76 9.48 56 439899 4052 90184440
Hypervolaemia 21.69 9.48 249 439706 32508 90155984
Neutropenic sepsis 21.68 9.48 34 439921 18096 90170396
Myalgia 21.68 9.48 1049 438906 174076 90014416
Breast pain 21.56 9.48 104 439851 10314 90178178
Musculoskeletal discomfort 21.55 9.48 175 439780 20816 90167676
Osteomyelitis 21.37 9.48 218 439737 27628 90160864
Postmortem blood drug level abnormal 21.35 9.48 14 439941 238 90188254
Breakthrough pain 21.23 9.48 30 439925 1377 90187115
Dependence 20.96 9.48 37 439918 2058 90186434
Hospice care 20.90 9.48 98 439857 9606 90178886
Incontinence 20.90 9.48 124 439831 13311 90175181
Cytokine release syndrome 20.77 9.48 68 439887 27905 90160587
Blood glucose decreased 20.73 9.48 189 439766 23240 90165252
Low birth weight baby 20.71 9.48 10 439945 9457 90179035
Migraine 20.62 9.48 1126 438829 189266 89999226
Transplant rejection 20.49 9.48 19 439936 12739 90175753
Wrist fracture 20.45 9.48 138 439817 15486 90173006
Haemophagocytic lymphohistiocytosis 20.45 9.48 27 439928 15432 90173060
Foetal growth restriction 20.38 9.48 10 439945 9370 90179122
Sternal fracture 20.36 9.48 44 439911 2843 90185649
Dry mouth 20.33 9.48 710 439245 183349 90005143
Conversion disorder 20.31 9.48 37 439918 2109 90186383
Allergic reaction to excipient 20.31 9.48 22 439933 766 90187726
Substance use 20.25 9.48 27 439928 1172 90187320
Post herpetic neuralgia 20.19 9.48 42 439913 2642 90185850
Hypoxic-ischaemic encephalopathy 20.12 9.48 59 439896 4609 90183883
Chronic idiopathic pain syndrome 20.12 9.48 9 439946 67 90188425
Psychotic disorder 20.06 9.48 236 439719 30994 90157498
Neuromyelitis optica spectrum disorder 19.91 9.48 30 439925 1460 90187032
Sleep talking 19.89 9.48 26 439929 1107 90187385
Electroencephalogram abnormal 19.84 9.48 54 439901 4042 90184450
Breast cancer stage I 19.81 9.48 11 439944 9613 90178879
Economic problem 19.79 9.48 47 439908 3234 90185258
Hypertonic bladder 19.75 9.48 56 439899 4292 90184200
Glaucoma 19.69 9.48 170 439785 20585 90167907
Bone pain 19.66 9.48 416 439539 61567 90126925
Decubitus ulcer 19.66 9.48 111 439844 11702 90176790
Optic neuritis 19.59 9.48 96 439859 9582 90178910
Upper limb fracture 19.57 9.48 175 439780 21403 90167089
Neurosis 19.51 9.48 16 439939 389 90188103
Anaphylactic shock 19.47 9.48 83 439872 31534 90156958
Brain death 19.46 9.48 53 439902 3968 90184524
Eye pain 19.46 9.48 312 439643 43856 90144636
Hypoglycaemia 19.39 9.48 460 439495 69388 90119104
Feeling of body temperature change 19.39 9.48 66 439889 5583 90182909
Anaemia 19.38 9.48 1462 438493 351340 89837152
Emotional disorder 19.35 9.48 132 439823 14865 90173627
Product physical issue 19.32 9.48 66 439889 5594 90182898
Immune system disorder 19.24 9.48 111 439844 11794 90176698
Dry skin 19.24 9.48 562 439393 87511 90100981
Product quality issue 19.24 9.48 270 439685 79055 90109437
Band sensation 19.18 9.48 26 439929 1147 90187345
Pulmonary thrombosis 19.06 9.48 96 439859 9686 90178806
Osteosclerosis 19.00 9.48 55 439900 4265 90184227
Dysgeusia 18.75 9.48 359 439596 52201 90136291
Mastoiditis 18.69 9.48 31 439924 1639 90186853
Oesophageal obstruction 18.68 9.48 20 439935 687 90187805
Quality of life decreased 18.66 9.48 110 439845 11779 90176713
Progressive multiple sclerosis 18.65 9.48 27 439928 1267 90187225
Head banging 18.61 9.48 16 439939 416 90188076
Dermatitis atopic 18.61 9.48 185 439770 23287 90165205
Initial insomnia 18.59 9.48 92 439863 9218 90179274
Creatinine renal clearance decreased 18.54 9.48 40 439915 18859 90169633
Postmortem blood drug level increased 18.50 9.48 20 439935 695 90187797
Face injury 18.43 9.48 51 439904 3854 90184638
Skin reaction 18.43 9.48 39 439916 18514 90169978
Glycosylated haemoglobin decreased 18.29 9.48 19 439936 630 90187862
Rash vesicular 18.28 9.48 38 439917 18159 90170333
Rectal haemorrhage 18.21 9.48 287 439668 82457 90106035
Chills 18.15 9.48 799 439156 131182 90057310
Intervertebral disc disorder 18.05 9.48 63 439892 5397 90183095
Delusion of parasitosis 18.05 9.48 10 439945 123 90188369
Mania 18.04 9.48 124 439831 14000 90174492
Tonic clonic movements 17.99 9.48 31 439924 1691 90186801
Sacroiliitis 17.87 9.48 53 439902 4166 90184326
Subdural hygroma 17.80 9.48 13 439942 265 90188227
Obstructive airways disorder 17.78 9.48 65 439890 25804 90162688
Abortion spontaneous 17.77 9.48 172 439783 53884 90134608
Miosis 17.73 9.48 92 439863 9392 90179100
Aphasia 17.59 9.48 299 439656 42513 90145979
Product adhesion issue 17.58 9.48 60 439895 5082 90183410
Drug screen negative 17.51 9.48 14 439941 328 90188164
Poor quality sleep 17.39 9.48 190 439765 24503 90163989
Musculoskeletal chest pain 17.31 9.48 184 439771 23566 90164926
Homicidal ideation 17.24 9.48 31 439924 1749 90186743
Osteonecrosis of jaw 17.20 9.48 115 439840 38988 90149504
Retching 17.18 9.48 155 439800 19004 90169488
Ear pain 17.16 9.48 188 439767 57514 90130978
Lumbar spinal stenosis 17.16 9.48 63 439892 5534 90182958
Electrocardiogram QT prolonged 17.12 9.48 467 439488 71989 90116503
Rotator cuff syndrome 17.04 9.48 134 439821 15785 90172707
Gout 17.01 9.48 140 439815 16719 90171773
Nerve block 17.00 9.48 21 439934 844 90187648
Deep vein thrombosis 16.95 9.48 573 439382 91047 90097445
Bedridden 16.93 9.48 109 439846 12039 90176453
Metastases to liver 16.90 9.48 77 439878 28730 90159762
Bronchiectasis 16.77 9.48 54 439901 22276 90166216
Ligament rupture 16.76 9.48 48 439907 3700 90184792
Oesophageal pain 16.71 9.48 53 439902 4321 90184171
Skin toxicity 16.70 9.48 6 439949 6773 90181719
Central nervous system infection 16.70 9.48 21 439934 860 90187632
Epidermal necrosis 16.67 9.48 36 439919 2325 90186167
Colitis 16.63 9.48 239 439716 69703 90118789
Hypoventilation 16.56 9.48 60 439895 5236 90183256
Narcolepsy 16.56 9.48 28 439927 1504 90186988
Carbuncle 16.53 9.48 27 439928 1409 90187083
Skin laceration 16.39 9.48 196 439759 25839 90162653
Loss of control of legs 16.34 9.48 27 439928 1423 90187069
Skin discolouration 16.26 9.48 304 439651 44011 90144481
Blood lactic acid 16.22 9.48 9 439946 111 90188381
Hysterectomy 16.18 9.48 104 439851 11480 90177012
General symptom 16.16 9.48 29 439926 14639 90173853
Essential hypertension 16.04 9.48 67 439888 6248 90182244
Ankylosing spondylitis 16.01 9.48 114 439841 13019 90175473
Wrong patient received product 16.01 9.48 45 439910 3432 90185060
Injection site erythema 15.99 9.48 607 439348 97895 90090597
Hyperlipidaemia 15.99 9.48 176 439779 22740 90165752
Snoring 15.97 9.48 58 439897 5068 90183424
Muscular weakness 15.92 9.48 1187 438768 205479 89983013
Hyperbilirubinaemia 15.85 9.48 27 439928 13909 90174583
Major depression 15.85 9.48 93 439862 9942 90178550
Toxic skin eruption 15.80 9.48 33 439922 15741 90172751
Allodynia 15.70 9.48 22 439933 1002 90187490
Chronic kidney disease 15.64 9.48 336 439619 49855 90138637
Urinary hesitation 15.64 9.48 36 439919 2427 90186065
Gastrooesophageal reflux disease 15.64 9.48 654 439301 165683 90022809
Transaminases increased 15.56 9.48 111 439844 37081 90151411
Metabolic surgery 15.53 9.48 28 439927 1583 90186909
Lumbar radiculopathy 15.50 9.48 37 439918 2554 90185938
Neurogenic bladder 15.39 9.48 46 439909 3632 90184860
Product availability issue 15.38 9.48 74 439881 7330 90181162
Clumsiness 15.35 9.48 37 439918 2570 90185922
Gastrointestinal toxicity 15.32 9.48 14 439941 9453 90179039
Pancreatitis chronic 15.32 9.48 39 439916 2804 90185688
Psychomotor skills impaired 15.06 9.48 39 439916 2833 90185659
Blood potassium abnormal 15.03 9.48 40 439915 2954 90185538
Magnetic resonance imaging abnormal 14.97 9.48 44 439911 3442 90185050
Pre-eclampsia 14.92 9.48 19 439936 11029 90177463
Obsessive-compulsive disorder 14.92 9.48 52 439903 4452 90184040
Intrusive thoughts 14.90 9.48 14 439941 410 90188082
Pain of skin 14.88 9.48 131 439824 15951 90172541
Nitrite urine present 14.81 9.48 22 439933 1057 90187435
Accident 14.81 9.48 70 439885 6884 90181608
Toxicologic test abnormal 14.76 9.48 18 439937 714 90187778
Scratch 14.67 9.48 90 439865 9776 90178716
Areflexia 14.64 9.48 45 439910 3608 90184884
Dysphoria 14.64 9.48 64 439891 6090 90182402
Facial paralysis 14.61 9.48 127 439828 15407 90173085
Skin cancer 14.58 9.48 114 439841 13405 90175087
Craniorachischisis 14.58 9.48 4 439951 4 90188488
Umbilical cord short 14.57 9.48 5 439950 16 90188476
Monoclonal immunoglobulin present 14.55 9.48 32 439923 2092 90186400
Hand fracture 14.54 9.48 69 439886 6796 90181696
Mitochondrial encephalomyopathy 14.54 9.48 8 439947 97 90188395
Orgasm abnormal 14.54 9.48 8 439947 97 90188395
Myotonia 14.52 9.48 10 439945 185 90188307
Urine amphetamine positive 14.52 9.48 7 439948 63 90188429
Gestational diabetes 14.50 9.48 18 439937 10564 90177928
Abortion induced 14.50 9.48 22 439933 11866 90176626
Confusional arousal 14.45 9.48 12 439943 297 90188195
Mood swings 14.45 9.48 159 439796 20543 90167949
Back disorder 14.44 9.48 189 439766 25442 90163050
Dysgraphia 14.42 9.48 45 439910 3638 90184854
Agranulocytosis 14.38 9.48 105 439850 34897 90153595
Decreased appetite 14.37 9.48 1604 438351 374936 89813556
Femoral artery dissection 14.36 9.48 6 439949 37 90188455
Spinal cord injury 14.35 9.48 22 439933 1087 90187405
Morbid thoughts 14.33 9.48 18 439937 736 90187756
Self-injurious ideation 14.30 9.48 41 439914 3162 90185330
Feeling of despair 14.30 9.48 41 439914 3163 90185329
Neck surgery 14.18 9.48 31 439924 2019 90186473
Acute myeloid leukaemia 14.09 9.48 52 439903 20588 90167904
Respiratory rate decreased 14.08 9.48 47 439908 3936 90184556
Drug reaction with eosinophilia and systemic symptoms 14.07 9.48 136 439819 42622 90145870
Myelodysplastic syndrome 14.05 9.48 53 439902 20850 90167642
Urine odour abnormal 14.05 9.48 71 439884 7173 90181319
Stereotypy 14.04 9.48 14 439941 442 90188050
Phobia 14.00 9.48 13 439942 375 90188117
Toxic encephalopathy 13.99 9.48 81 439874 8618 90179874
Rash maculo-papular 13.98 9.48 129 439826 40804 90147688
Inability to afford medication 13.94 9.48 44 439911 3578 90184914
Atonic urinary bladder 13.93 9.48 9 439946 149 90188343
Upper respiratory tract infection 13.91 9.48 759 439196 127559 90060933
Pneumonia 13.86 9.48 3394 436561 634665 89553827
Myositis 13.85 9.48 65 439890 24063 90164429
Device infusion issue 13.81 9.48 36 439919 2626 90185866
Eyelid pain 13.79 9.48 18 439937 765 90187727
Epstein-Barr virus infection 13.75 9.48 18 439937 10326 90178166
Malignant urinary tract neoplasm 13.70 9.48 4 439951 6 90188486
Gambling disorder 13.69 9.48 23 439932 1229 90187263
CD8 lymphocytes decreased 13.68 9.48 10 439945 204 90188288
Frustration tolerance decreased 13.68 9.48 75 439880 7821 90180671
Eyelid myoclonus 13.67 9.48 8 439947 110 90188382
Adjustment disorder 13.63 9.48 16 439939 9626 90178866
Nasal disorder 13.61 9.48 41 439914 3251 90185241
Dermatillomania 13.60 9.48 11 439944 262 90188230
Stress urinary incontinence 13.59 9.48 34 439921 2418 90186074
Mucocutaneous haemorrhage 13.54 9.48 8 439947 112 90188380
Regressive behaviour 13.52 9.48 10 439945 208 90188284
Hepatitis C virus test positive 13.48 9.48 8 439947 113 90188379
Staphylococcal infection 13.44 9.48 319 439636 48120 90140372
Nasal polyps 13.40 9.48 20 439935 10860 90177632
Internal hernia 13.39 9.48 7 439948 76 90188416
CSF white blood cell count increased 13.37 9.48 6 439949 45 90188447
Deprescribing error 13.37 9.48 6 439949 45 90188447
Sleep paralysis 13.33 9.48 19 439936 879 90187613
Pregnancy with contraceptive device 13.33 9.48 4 439951 5062 90183430
Skin tightness 13.32 9.48 50 439905 4438 90184054
Heteroplasia 13.32 9.48 4 439951 7 90188485
Prophylaxis 13.32 9.48 4 439951 7 90188485
Neuroma 13.31 9.48 14 439941 471 90188021
Hyperprolactinaemia 13.30 9.48 57 439898 5376 90183116
Adverse reaction 13.26 9.48 87 439868 29625 90158867
Fibula fracture 13.25 9.48 48 439907 4189 90184303
Nephrolithiasis 13.24 9.48 322 439633 48763 90139729
Naevus haemorrhage 13.24 9.48 8 439947 117 90188375
Ascites 13.23 9.48 158 439797 47582 90140910
Steatohepatitis 13.21 9.48 18 439937 798 90187694
Gastroschisis 13.17 9.48 13 439942 405 90188087
Otitis media 13.17 9.48 60 439895 5810 90182682
Hyporeflexia 13.17 9.48 32 439923 2234 90186258
Limb operation 13.08 9.48 50 439905 4477 90184015
Hallucinations, mixed 13.07 9.48 60 439895 5829 90182663
Intentional underdose 13.07 9.48 30 439925 2019 90186473
Infusion site pain 13.05 9.48 150 439805 19588 90168904
Post-traumatic neck syndrome 13.04 9.48 34 439921 2480 90186012
Epidermal naevus 13.00 9.48 3 439952 0 90188492
Fracture infection 13.00 9.48 3 439952 0 90188492
Turbinectomy 13.00 9.48 3 439952 0 90188492
CSF neutrophil count increased 13.00 9.48 3 439952 0 90188492
Dysacusis 13.00 9.48 3 439952 0 90188492
Pulse absent 12.93 9.48 61 439894 5994 90182498
Essential tremor 12.93 9.48 24 439931 1388 90187104
Application site vesicles 12.92 9.48 25 439930 1492 90187000
Leukopenia 12.91 9.48 381 439574 100329 90088163
Parapsoriasis 12.89 9.48 8 439947 123 90188369
Oral mucosal blistering 12.83 9.48 67 439888 6857 90181635
Neutropenia 12.82 9.48 929 439026 223975 89964517
Defect conduction intraventricular 12.81 9.48 10 439945 226 90188266
Sudden onset of sleep 12.80 9.48 15 439940 570 90187922
Coronary artery disease 12.80 9.48 232 439723 33391 90155101
Tuberculosis 12.78 9.48 26 439929 12523 90175969
Device difficult to use 12.74 9.48 43 439912 17482 90171010
Rash papular 12.71 9.48 153 439802 20202 90168290
Choreoathetosis 12.66 9.48 15 439940 577 90187915
Vertebral foraminal stenosis 12.61 9.48 21 439934 1114 90187378
Sciatic nerve injury 12.59 9.48 17 439938 747 90187745
Psychiatric symptom 12.59 9.48 68 439887 7050 90181442
Hyperacusis 12.57 9.48 36 439919 2775 90185717
Hallucination, tactile 12.57 9.48 13 439942 429 90188063
Dysphonia 12.56 9.48 398 439557 62686 90125806
Gastrointestinal tube insertion 12.55 9.48 23 439932 1317 90187175
Carotid artery disease 12.55 9.48 26 439929 1631 90186861
Maternal exposure before pregnancy 12.50 9.48 22 439933 11191 90177301
Vomiting 12.49 9.48 3523 436432 784770 89403722
Bone contusion 12.47 9.48 21 439934 1124 90187368
Oligohydramnios 12.44 9.48 10 439945 7191 90181301
Burning mouth syndrome 12.44 9.48 15 439940 588 90187904
Graft versus host disease in gastrointestinal tract 12.42 9.48 3 439952 4385 90184107
Clostridium difficile infection 12.40 9.48 246 439709 35999 90152493
Hypotension 12.37 9.48 1781 438174 323616 89864876
Vitamin D decreased 12.37 9.48 100 439855 11879 90176613
Prescribed overdose 12.34 9.48 370 439585 97255 90091237
Pruritus 12.34 9.48 2379 437576 539146 89649346
Violence-related symptom 12.28 9.48 15 439940 596 90187896
Malignant polyp 12.26 9.48 9 439946 185 90188307
Connective tissue inflammation 12.26 9.48 6 439949 56 90188436
Time perception altered 12.26 9.48 6 439949 56 90188436
Tendon injury 12.23 9.48 31 439924 2222 90186270
Hypokalaemia 12.22 9.48 516 439439 130600 90057892
Oral discomfort 12.21 9.48 90 439865 10393 90178099
Temperature intolerance 12.19 9.48 100 439855 11930 90176562
Eye contusion 12.18 9.48 34 439921 2582 90185910
Choking 12.18 9.48 100 439855 11933 90176559
Affective disorder 12.17 9.48 72 439883 7721 90180771
Screaming 12.17 9.48 43 439912 3707 90184785
Expired product administered 12.16 9.48 66 439889 6856 90181636
Autonomic dysreflexia 12.16 9.48 12 439943 374 90188118
Application site burn 12.16 9.48 19 439936 955 90187537
Urosepsis 12.14 9.48 157 439798 21075 90167417
Vulvar basal cell carcinoma 12.08 9.48 5 439950 30 90188462
Graft versus host disease 12.08 9.48 13 439942 8131 90180361
Acute graft versus host disease in skin 12.08 9.48 4 439951 4752 90183740
Hypoacusis 11.99 9.48 196 439759 27654 90160838
Schizophrenia 11.96 9.48 35 439920 14879 90173613
Panic reaction 11.95 9.48 50 439905 4667 90183825
Fractured coccyx 11.94 9.48 22 439933 1265 90187227
Gastric bypass 11.93 9.48 29 439926 2025 90186467
Paraplegia 11.83 9.48 40 439915 3372 90185120
Infusion site infection 11.83 9.48 34 439921 2626 90185866
Cystitis haemorrhagic 11.79 9.48 6 439949 5507 90182985
Injection site nodule 11.79 9.48 48 439907 4425 90184067
Cervical vertebral fracture 11.77 9.48 39 439916 3254 90185238
Melaena 11.74 9.48 110 439845 34687 90153805
Genital haemorrhage 11.71 9.48 15 439940 8687 90179805
Medication error 11.68 9.48 317 439638 84335 90104157
Libido increased 11.64 9.48 26 439929 1718 90186774
Disturbance in social behaviour 11.59 9.48 3 439952 4185 90184307
Soft tissue injury 11.59 9.48 29 439926 2063 90186429
Oral pain 11.58 9.48 223 439732 32460 90156032
Uveitis 11.57 9.48 39 439916 15864 90172628
Scar 11.56 9.48 120 439835 15275 90173217
Nasal oedema 11.56 9.48 9 439946 6575 90181917
Product substitution issue 11.53 9.48 136 439819 17872 90170620
Hypertensive emergency 11.52 9.48 30 439925 2187 90186305
Therapeutic product effect variable 11.48 9.48 24 439931 1515 90186977
Lung adenocarcinoma stage I 11.44 9.48 5 439950 35 90188457
Knee operation 11.43 9.48 65 439890 6871 90181621
Breast swelling 11.42 9.48 25 439930 1629 90186863
Status epilepticus 11.41 9.48 141 439814 18733 90169759
Aspergillus infection 11.39 9.48 22 439933 10801 90177691
Cutaneous T-cell lymphoma stage II 11.38 9.48 4 439951 14 90188478
Anuria 11.37 9.48 116 439839 14702 90173790
Pancreatic disorder 11.35 9.48 36 439919 2935 90185557
Facial bones fracture 11.34 9.48 42 439913 3705 90184787
Cerebral vasoconstriction 11.33 9.48 21 439934 1213 90187279
Gait apraxia 11.32 9.48 5 439950 36 90188456
Product selection error 11.29 9.48 10 439945 271 90188221
Cardiotoxicity 11.26 9.48 24 439931 11365 90177127
Post-traumatic stress disorder 11.26 9.48 64 439891 6764 90181728
Blood iron decreased 11.22 9.48 135 439820 17824 90170668
CD4 lymphocytes abnormal 11.20 9.48 5 439950 37 90188455
Intervertebral disc compression 11.20 9.48 21 439934 1224 90187268
Neuroendocrine carcinoma 11.19 9.48 11 439944 341 90188151
Septic encephalopathy 11.13 9.48 8 439947 159 90188333
Myofascial pain syndrome 11.09 9.48 36 439919 2971 90185521
Swollen tongue 11.08 9.48 297 439658 45659 90142833
Drug tolerance 11.05 9.48 47 439908 17869 90170623
Infected skin ulcer 11.01 9.48 33 439922 2609 90185883
Congenital neuropathy 10.97 9.48 4 439951 16 90188476
Breast mass 10.94 9.48 81 439874 9366 90179126
Bronchomalacia 10.93 9.48 9 439946 220 90188272
Muscle relaxant drug level above therapeutic 10.93 9.48 3 439952 3 90188489
Diabetic gastropathy 10.93 9.48 3 439952 3 90188489
Nervous system cyst 10.93 9.48 3 439952 3 90188489
Radial nerve injury 10.93 9.48 3 439952 3 90188489
Arterial occlusive disease 10.89 9.48 28 439927 12418 90176074
Blood thyroid stimulating hormone normal 10.83 9.48 7 439948 116 90188376
Eye movement disorder 10.82 9.48 59 439896 6139 90182353
Symmetrical drug-related intertriginous and flexural exanthema 10.72 9.48 18 439937 961 90187531
Blood sodium decreased 10.68 9.48 191 439764 27422 90161070
Unintentional medical device removal 10.67 9.48 11 439944 7019 90181473
Blood creatinine increased 10.65 9.48 598 439357 100788 90087704
Bipolar I disorder 10.64 9.48 28 439927 2054 90186438
Furuncle 10.64 9.48 68 439887 7493 90180999
Cervical radiculopathy 10.62 9.48 22 439933 1380 90187112
Noninfective encephalitis 10.59 9.48 13 439942 519 90187973
Retroplacental haematoma 10.55 9.48 8 439947 173 90188319
Vasculitic rash 10.53 9.48 22 439933 1388 90187104
Product taste abnormal 10.51 9.48 31 439924 2429 90186063
Middle insomnia 10.50 9.48 126 439829 16625 90171867
Pruritus allergic 10.50 9.48 25 439930 1723 90186769
Proteinuria 10.49 9.48 68 439887 23223 90165269
Visual impairment 10.49 9.48 762 439193 131603 90056889
Cerebral disorder 10.48 9.48 55 439900 5639 90182853
Cerebral palsy 10.47 9.48 9 439946 234 90188258
Enterocolitis 10.46 9.48 22 439933 10468 90178024
Red blood cell count decreased 10.46 9.48 297 439658 46054 90142438
Cancer pain 10.46 9.48 43 439912 3982 90184510
Alkalosis hypochloraemic 10.44 9.48 9 439946 235 90188257
Enzyme abnormality 10.39 9.48 8 439947 177 90188315
Libido decreased 10.38 9.48 35 439920 2947 90185545
Akathisia 10.38 9.48 91 439864 11068 90177424
Progressive relapsing multiple sclerosis 10.37 9.48 5 439950 45 90188447
Cerebral infarction 10.35 9.48 81 439874 26515 90161977
Cold-stimulus headache 10.35 9.48 6 439949 81 90188411
Organising pneumonia 10.33 9.48 13 439942 7584 90180908
Pulmonary granuloma 10.32 9.48 24 439931 1629 90186863
Blood pressure systolic abnormal 10.31 9.48 54 439901 19424 90169068
Phyllodes tumour 10.28 9.48 6 439949 82 90188410
Enamel anomaly 10.26 9.48 4 439951 20 90188472
Tooth infection 10.25 9.48 146 439809 20024 90168468
Basal cell carcinoma 10.24 9.48 108 439847 33281 90155211
Vestibular disorder 10.23 9.48 23 439932 1526 90186966
Vaginal cancer 10.23 9.48 10 439945 308 90188184
Cold sweat 10.22 9.48 109 439846 13972 90174520
Parosmia 10.21 9.48 64 439891 7005 90181487
Cushingoid 10.20 9.48 22 439933 10373 90178119
Dysuria 10.19 9.48 257 439698 39144 90149348
Presbyopia 10.18 9.48 14 439941 626 90187866
Bladder catheterisation 10.18 9.48 11 439944 382 90188110
Symptom masked 10.17 9.48 18 439937 1003 90187489
Nystagmus 10.17 9.48 65 439890 7162 90181330
Carotid artery occlusion 10.16 9.48 59 439896 6283 90182209
Hepatic steatosis 10.16 9.48 243 439712 36702 90151790
Hair growth abnormal 10.13 9.48 40 439915 3636 90184856
Lymphoproliferative disorder 10.12 9.48 4 439951 4258 90184234
Urine leukocyte esterase positive 10.11 9.48 37 439918 3245 90185247
Light chain analysis increased 10.10 9.48 23 439932 1539 90186953
Psychiatric evaluation 10.10 9.48 4 439951 21 90188471
Rapid eye movements sleep abnormal 10.10 9.48 7 439948 131 90188361
Globulin abnormal 10.08 9.48 3 439952 5 90188487
Bladder spasm 10.07 9.48 27 439928 2003 90186489
Inappropriate schedule of product administration 10.05 9.48 852 439103 149081 90039411
Musculoskeletal disorder 10.05 9.48 155 439800 21614 90166878
Distributive shock 10.04 9.48 38 439917 3386 90185106
Bradypnoea 10.00 9.48 47 439908 4611 90183881
Blood sodium abnormal 9.97 9.48 16 439939 823 90187669
Increased appetite 9.95 9.48 94 439861 11671 90176821
Blindness unilateral 9.93 9.48 68 439887 7668 90180824
Urine abnormality 9.92 9.48 68 439887 7669 90180823
Injection site atrophy 9.89 9.48 16 439939 828 90187664
Tunnel vision 9.86 9.48 24 439931 1677 90186815
Bronchopulmonary aspergillosis allergic 9.86 9.48 3 439952 3763 90184729
Drug effective for unapproved indication 9.81 9.48 69 439886 7849 90180643
Upper airway resistance syndrome 9.80 9.48 4 439951 23 90188469
Mitochondrial toxicity 9.80 9.48 14 439941 649 90187843
Thoracic outlet syndrome 9.80 9.48 12 439943 478 90188014
Tooth injury 9.80 9.48 22 439933 1459 90187033
Congenital hand malformation 9.79 9.48 10 439945 325 90188167
Physical examination abnormal 9.74 9.48 7 439948 139 90188353
Eye disorder 9.74 9.48 187 439768 27203 90161289
Product residue present 9.73 9.48 44 439911 4247 90184245
Premature ageing 9.73 9.48 3 439952 6 90188486
Therapeutic nerve ablation 9.73 9.48 3 439952 6 90188486
Renal adenoma 9.73 9.48 3 439952 6 90188486
Secondary adrenocortical insufficiency 9.71 9.48 29 439926 2289 90186203
Haemangioma of skin 9.69 9.48 14 439941 656 90187836
Posterior reversible encephalopathy syndrome 9.67 9.48 66 439889 22273 90166219
Vitamin A decreased 9.65 9.48 7 439948 141 90188351
Ear disorder 9.63 9.48 47 439908 4683 90183809
Cardiomegaly 9.62 9.48 137 439818 18788 90169704
Wrong product administered 9.62 9.48 67 439888 7598 90180894
Hair colour changes 9.61 9.48 38 439917 3456 90185036
Injection site infection 9.60 9.48 29 439926 2303 90186189
Injection site necrosis 9.60 9.48 22 439933 1479 90187013
Breast adenoma 9.59 9.48 5 439950 54 90188438
Oesophageal disorder 9.58 9.48 32 439923 2681 90185811
Pharyngeal abscess 9.58 9.48 11 439944 409 90188083
Porphyria 9.57 9.48 8 439947 200 90188292
Caesarean section 9.55 9.48 52 439903 18525 90169967
Laryngectomy 9.53 9.48 4 439951 25 90188467
Arthropod bite 9.50 9.48 74 439881 8693 90179799

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 849.83 10.74 1768 241180 94697 42283690
Drug hypersensitivity 770.60 10.74 1730 241218 97659 42280728
Myoclonus 379.00 10.74 477 242471 16588 42361799
Drug ineffective for unapproved indication 332.34 10.74 781 242167 45382 42333005
Somnolence 318.59 10.74 1618 241330 139487 42238900
Sedation 288.50 10.74 576 242372 29899 42348488
Toxicity to various agents 280.04 10.74 2247 240701 226889 42151498
Drug abuse 252.38 10.74 1224 241724 103547 42274840
Drug withdrawal syndrome 240.64 10.74 437 242511 21112 42357275
Drug dependence 234.66 10.74 515 242433 28579 42349808
Interstitial lung disease 199.20 10.74 99 242849 78363 42300024
Nightmare 178.67 10.74 422 242526 24590 42353797
Febrile neutropenia 170.23 10.74 519 242429 185184 42193203
Euphoric mood 167.09 10.74 195 242753 6258 42372129
Confusional state 160.10 10.74 1558 241390 166039 42212348
Fall 157.95 10.74 2035 240913 232485 42145902
Myelosuppression 152.42 10.74 24 242924 40437 42337950
Multiple sclerosis relapse 145.16 10.74 278 242670 13986 42364401
Depression 144.43 10.74 1108 241840 110255 42268132
Therapeutic product effect variable 140.86 10.74 127 242821 2982 42375405
Disinhibition 134.54 10.74 137 242811 3758 42374629
Withdrawal syndrome 133.53 10.74 274 242674 14501 42363886
Antipsychotic drug level below therapeutic 129.88 10.74 123 242825 3081 42375306
Obsessive-compulsive disorder 125.72 10.74 173 242775 6570 42371817
Inspiratory capacity decreased 122.37 10.74 115 242833 2852 42375535
Hepatic function abnormal 117.97 10.74 74 242874 51493 42326894
Insomnia 116.62 10.74 1107 241841 117146 42261241
Thrombocytopenia 116.09 10.74 624 242324 189655 42188732
Pyrexia 115.16 10.74 1569 241379 392473 41985914
Hypoaesthesia 114.78 10.74 749 242199 70714 42307673
Memory impairment 114.57 10.74 578 242370 49644 42328743
Respiratory arrest 113.83 10.74 389 242559 28035 42350352
Neutropenia 112.49 10.74 671 242277 198760 42179627
Pain 111.31 10.74 1987 240961 242861 42135526
Cytomegalovirus infection 111.30 10.74 24 242924 32282 42346105
Tremor 110.75 10.74 937 242011 95992 42282395
Cardiac failure 107.86 10.74 285 242663 106571 42271816
Mental status changes 107.06 10.74 500 242448 41615 42336772
Balance disorder 107.04 10.74 546 242402 47099 42331288
Pain in extremity 105.53 10.74 1317 241631 149287 42229100
Increased appetite 102.46 10.74 183 242765 8723 42369664
C-reactive protein increased 100.20 10.74 129 242819 63431 42314956
Drug resistance 100.12 10.74 35 242913 34213 42344174
Anaemia 98.08 10.74 1073 241875 279205 42099182
Neuropathy peripheral 97.69 10.74 948 242000 100905 42277482
Renal impairment 94.64 10.74 317 242631 109911 42268476
Neuralgia 89.88 10.74 336 242612 25311 42353076
Respiratory depression 89.84 10.74 274 242674 18594 42359793
Dizziness 88.46 10.74 1949 240999 247305 42131082
Disease progression 88.18 10.74 470 242478 143186 42235201
Intentional product misuse 85.33 10.74 625 242323 61275 42317112
Muscle spasticity 84.74 10.74 145 242803 6677 42371710
Mucosal inflammation 84.43 10.74 94 242854 49280 42329107
Septic shock 84.03 10.74 256 242692 91416 42286971
Appendicolith 81.29 10.74 213 242735 13243 42365144
Gait disturbance 80.13 10.74 883 242065 97117 42281270
Muscle spasms 79.15 10.74 794 242154 85250 42293137
Overdose 76.91 10.74 928 242020 104336 42274051
Serotonin syndrome 76.39 10.74 321 242627 25524 42352863
Dysarthria 75.10 10.74 435 242513 39372 42339015
Ataxia 72.00 10.74 229 242719 15896 42362491
Plasma cell myeloma 69.39 10.74 487 242461 47091 42331296
Alanine aminotransferase increased 69.38 10.74 264 242684 88142 42290245
Hallucination 68.35 10.74 561 242387 56946 42321441
Right atrial hypertrophy 68.30 10.74 46 242902 691 42377696
Disseminated intravascular coagulation 66.43 10.74 29 242919 24765 42353622
Depressed level of consciousness 65.90 10.74 484 242464 47486 42330901
Bone marrow failure 63.46 10.74 57 242891 33036 42345351
Multiple sclerosis 62.95 10.74 136 242812 7462 42370925
Constipation 62.64 10.74 1285 241663 161006 42217381
Malignant neoplasm progression 61.94 10.74 363 242585 108037 42270350
Haemophagocytic lymphohistiocytosis 61.83 10.74 14 242934 18208 42360179
Anxiety 61.71 10.74 984 241964 117576 42260811
Prescription drug used without a prescription 61.69 10.74 77 242871 2653 42375734
Feeling abnormal 60.84 10.74 637 242311 69149 42309238
Appendicitis 60.12 10.74 255 242693 20358 42358029
Pulmonary alveolar haemorrhage 60.03 10.74 7 242941 14809 42363578
Product complaint 57.77 10.74 114 242834 5863 42372524
Bronchopulmonary aspergillosis 56.54 10.74 20 242928 19409 42358978
Intervertebral disc degeneration 55.56 10.74 127 242821 7240 42371147
Amnesia 55.10 10.74 313 242635 28124 42350263
Neutrophil count decreased 54.66 10.74 182 242766 63233 42315154
Drug reaction with eosinophilia and systemic symptoms 54.17 10.74 98 242850 41977 42336410
Aspergillus infection 54.07 10.74 12 242936 15825 42362562
Fatigue 53.85 10.74 3015 239933 432626 41945761
Suspected suicide 53.71 10.74 113 242835 6086 42372301
Hyperhidrosis 53.59 10.74 768 242180 89744 42288643
Irritability 52.80 10.74 307 242641 27821 42350566
Cytokine release syndrome 52.72 10.74 109 242839 44418 42333969
Suicidal ideation 52.56 10.74 461 242487 47700 42330687
Stress 52.36 10.74 431 242517 43781 42334606
Lethargy 52.30 10.74 451 242497 46439 42331948
Back disorder 50.66 10.74 124 242824 7390 42370997
Toxic epidermal necrolysis 50.19 10.74 47 242901 26703 42351684
Needle fatigue 50.00 10.74 47 242901 1166 42377221
Bronchial secretion retention 49.20 10.74 53 242895 1554 42376833
Colitis 48.66 10.74 122 242826 46450 42331937
Accidental death 48.54 10.74 73 242875 3010 42375377
Pneumonitis 47.82 10.74 104 242844 41614 42336773
Burning sensation 47.31 10.74 241 242707 20772 42357615
Back pain 47.17 10.74 1099 241849 140677 42237710
Relapsing-remitting multiple sclerosis 47.00 10.74 50 242898 1445 42376942
Infusion related reaction 46.14 10.74 184 242764 60622 42317765
Gait spastic 45.85 10.74 48 242900 1361 42377026
Bronchial wall thickening 45.46 10.74 47 242901 1313 42377074
Haematotoxicity 44.99 10.74 5 242943 10980 42367407
Myocarditis 44.95 10.74 26 242922 18912 42359475
Eosinophilia 44.75 10.74 74 242874 32825 42345562
Nephrolithiasis 44.67 10.74 361 242587 36469 42341918
Sleep apnoea syndrome 44.64 10.74 242 242706 21366 42357021
Metabolic acidosis 44.57 10.74 149 242799 51709 42326678
Pneumocystis jirovecii pneumonia 44.08 10.74 47 242901 25134 42353253
Akathisia 43.57 10.74 145 242803 10306 42368081
Melaena 43.26 10.74 98 242850 38648 42339739
Vision blurred 43.01 10.74 482 242466 53217 42325170
Paraesthesia 42.95 10.74 622 242326 72837 42305550
Inadequate analgesia 42.43 10.74 70 242878 3127 42375260
Acute kidney injury 42.28 10.74 1689 241259 365648 42012739
Right ventricular hypertrophy 42.03 10.74 48 242900 1504 42376883
Bradypnoea 41.51 10.74 83 242865 4310 42374077
Agranulocytosis 41.50 10.74 69 242879 30543 42347844
Asterixis 41.43 10.74 45 242903 1332 42377055
Hyperreflexia 40.06 10.74 73 242875 3534 42374853
Pancytopenia 39.78 10.74 454 242494 117289 42261098
Gastrointestinal haemorrhage 39.10 10.74 362 242586 97364 42281023
Proteinuria 39.02 10.74 44 242904 22939 42355448
Hepatic failure 38.88 10.74 101 242847 37999 42340388
Gamma-glutamyltransferase increased 38.09 10.74 80 242868 32417 42345970
Myokymia 38.04 10.74 17 242931 105 42378282
Post transplant lymphoproliferative disorder 37.73 10.74 4 242944 9116 42369271
Dry mouth 37.61 10.74 370 242578 39509 42338878
Child abuse 37.61 10.74 35 242913 857 42377530
Cardio-respiratory arrest 37.30 10.74 504 242444 58132 42320255
Hypertonic bladder 36.95 10.74 56 242892 2325 42376062
Hyperaesthesia 36.75 10.74 95 242853 5857 42372530
Multiple organ dysfunction syndrome 36.47 10.74 365 242583 96670 42281717
Graft versus host disease 36.43 10.74 14 242934 12911 42365476
Synovitis 36.06 10.74 22 242926 15545 42362842
Victim of child abuse 36.03 10.74 39 242909 1150 42377237
C-reactive protein abnormal 36.01 10.74 5 242943 9256 42369131
Sopor 35.96 10.74 160 242788 13042 42365345
Jaundice 35.83 10.74 91 242857 34498 42343889
Adverse drug reaction 35.63 10.74 348 242600 37086 42341301
Cerebral haemorrhage 35.55 10.74 109 242839 38857 42339530
Erythema 35.39 10.74 423 242525 108370 42270017
Tumour lysis syndrome 35.14 10.74 45 242903 22186 42356201
Antidepressant drug level above therapeutic 35.13 10.74 21 242927 253 42378134
Aspartate aminotransferase increased 34.81 10.74 277 242671 76886 42301501
Urinary incontinence 34.69 10.74 227 242721 21441 42356946
Pathogen resistance 34.69 10.74 11 242937 11439 42366948
Nervousness 34.62 10.74 161 242787 13371 42365016
Acute respiratory distress syndrome 34.56 10.74 75 242873 30033 42348354
Delirium 34.48 10.74 454 242494 52065 42326322
Hypokalaemia 34.46 10.74 253 242695 71468 42306919
Dyspnoea 34.39 10.74 2120 240828 440501 41937886
Myasthenia gravis 34.20 10.74 182 242766 15955 42362432
General physical health deterioration 33.99 10.74 632 242316 150614 42227773
Blood bilirubin increased 33.24 10.74 126 242822 42126 42336261
Acute myeloid leukaemia 33.21 10.74 47 242901 22209 42356178
Renal failure 33.10 10.74 598 242350 143128 42235259
Pulmonary toxicity 32.89 10.74 5 242943 8650 42369737
Blood lactate dehydrogenase increased 32.46 10.74 62 242886 26019 42352368
Narcolepsy 31.86 10.74 28 242920 635 42377752
Gait inability 31.70 10.74 231 242717 22602 42355785
Analgesic drug level above therapeutic 31.49 10.74 21 242927 310 42378077
Leukaemia 31.48 10.74 88 242860 5684 42372703
Migraine 31.30 10.74 250 242698 25164 42353223
Cholangitis 31.28 10.74 11 242937 10716 42367671
Hypomagnesaemia 31.04 10.74 73 242875 28415 42349972
Venoocclusive liver disease 31.03 10.74 10 242938 10292 42368095
Spinal operation 31.00 10.74 72 242876 4148 42374239
Obstruction 30.98 10.74 60 242888 3043 42375344
Muscle twitching 30.76 10.74 141 242807 11639 42366748
Epidural lipomatosis 30.32 10.74 44 242904 1756 42376631
Dyskinesia 30.32 10.74 248 242700 25142 42353245
Breath holding 30.11 10.74 14 242934 96 42378291
Erectile dysfunction 30.10 10.74 244 242704 24669 42353718
Epstein-Barr virus infection 30.04 10.74 9 242939 9709 42368678
Diabetic neuropathy 30.04 10.74 74 242874 4428 42373959
Cerebral infarction 30.02 10.74 85 242863 31084 42347303
Hallucination, visual 29.96 10.74 214 242734 20806 42357581
Posterior reversible encephalopathy syndrome 29.87 10.74 18 242930 12803 42365584
Sweat gland disorder 29.75 10.74 14 242934 99 42378288
Restless legs syndrome 29.65 10.74 121 242827 9493 42368894
Cytomegalovirus viraemia 29.65 10.74 11 242937 10366 42368021
Analgesic therapy 29.44 10.74 93 242855 6431 42371956
Rash maculo-papular 29.40 10.74 112 242836 37391 42340996
Monoparesis 29.27 10.74 57 242891 2903 42375484
Pulmonary function test abnormal 29.26 10.74 54 242894 2640 42375747
Parasomnia 29.17 10.74 23 242925 446 42377941
Transplant rejection 29.05 10.74 21 242927 13567 42364820
Acute myocardial infarction 29.00 10.74 203 242745 57962 42320425
Infantile back arching 28.99 10.74 13 242935 81 42378306
Hostility 28.82 10.74 29 242919 784 42377603
Sciatica 28.69 10.74 100 242848 7277 42371110
Alcoholism 28.46 10.74 56 242892 2874 42375513
Aortic valve stenosis 28.31 10.74 57 242891 2975 42375412
Atrial fibrillation 28.13 10.74 594 242354 138999 42239388
Circulatory collapse 27.86 10.74 58 242890 23578 42354809
Haemolysis 27.68 10.74 10 242938 9579 42368808
Acute hepatic failure 27.57 10.74 34 242914 17039 42361348
Drug tolerance 27.38 10.74 59 242889 3231 42375156
Obesity 27.31 10.74 174 242774 16285 42362102
Blood phosphorus increased 27.05 10.74 142 242806 12383 42366004
Tongue thrust 26.89 10.74 10 242938 35 42378352
Product use in unapproved indication 26.80 10.74 1297 241651 183159 42195228
Eosinophilic granulomatosis with polyangiitis 26.70 10.74 8 242940 8630 42369757
Acute graft versus host disease in skin 26.64 10.74 5 242943 7419 42370968
Disorientation 26.62 10.74 321 242627 36068 42342319
Hyperbilirubinaemia 26.61 10.74 48 242900 20587 42357800
Contraindicated product administered 26.55 10.74 66 242882 25206 42353181
Hypothyroidism 26.34 10.74 94 242854 31990 42346397
Medication error 26.27 10.74 297 242651 32857 42345530
Labelled drug-drug interaction medication error 26.27 10.74 30 242918 15552 42362835
Pulmonary fibrosis 26.26 10.74 72 242876 26609 42351778
Hepatotoxicity 26.23 10.74 66 242882 25101 42353286
Agitation 26.02 10.74 513 242435 63801 42314586
Ischaemic stroke 25.83 10.74 55 242893 22178 42356209
Hepatic enzyme increased 25.77 10.74 154 242794 45630 42332757
Prostate cancer 25.74 10.74 149 242799 44494 42333893
Pleural effusion 25.73 10.74 394 242554 96772 42281615
Bradyphrenia 25.59 10.74 77 242871 5185 42373202
Swelling 25.39 10.74 447 242501 54438 42323949
Nerve injury 25.38 10.74 64 242884 3886 42374501
Inflammation 25.31 10.74 103 242845 33744 42344643
Sleep disorder 25.30 10.74 400 242548 47695 42330692
Delirium tremens 25.12 10.74 24 242924 608 42377779
Micturition urgency 25.08 10.74 134 242814 11764 42366623
Peripheral swelling 25.04 10.74 683 242265 89587 42288800
Lung disorder 25.01 10.74 165 242783 47758 42330629
Allodynia 24.95 10.74 31 242917 1063 42377324
Burns second degree 24.90 10.74 84 242864 6012 42372375
Mood altered 24.88 10.74 124 242824 10594 42367793
Prescribed overdose 24.85 10.74 142 242806 12785 42365602
Full blood count decreased 24.64 10.74 201 242747 20359 42358028
Drug eruption 24.45 10.74 60 242888 23015 42355372
Drug therapy 24.39 10.74 86 242862 6294 42372093
Haematuria 24.03 10.74 212 242736 57587 42320800
Immune reconstitution inflammatory syndrome 23.97 10.74 14 242934 10129 42368258
Gingival pain 23.94 10.74 104 242844 8390 42369997
Angioedema 23.84 10.74 143 242805 42334 42336053
Coordination abnormal 23.79 10.74 100 242848 7950 42370437
Road traffic accident 23.61 10.74 188 242760 18905 42359482
Hypoacusis 23.60 10.74 185 242763 18517 42359870
Cognitive disorder 23.52 10.74 298 242650 33874 42344513
Cough 23.30 10.74 806 242142 177297 42201090
Cardiac failure acute 23.25 10.74 26 242922 13607 42364780
Anger 23.09 10.74 140 242808 12878 42365509
Sleep disorder therapy 23.06 10.74 89 242859 6805 42371582
Intervertebral disc protrusion 22.87 10.74 124 242824 10948 42367439
Dissociation 22.82 10.74 60 242888 3738 42374649
Enterococcal infection 22.76 10.74 21 242927 12018 42366369
Product used for unknown indication 22.67 10.74 31 242917 1170 42377217
Vasculitis 22.65 10.74 44 242904 18350 42360037
Post-traumatic stress disorder 22.59 10.74 44 242904 2241 42376146
Cardiac arrest 22.58 10.74 798 242150 108522 42269865
Hepatocellular injury 22.49 10.74 65 242883 23613 42354774
Poor sucking reflex 22.41 10.74 18 242930 359 42378028
Product dose omission issue 22.32 10.74 1085 241863 153280 42225107
Accidental poisoning 22.30 10.74 32 242916 1264 42377123
Thrombotic microangiopathy 22.27 10.74 31 242917 14751 42363636
Suicide attempt 22.24 10.74 378 242570 45722 42332665
Palmar-plantar erythrodysaesthesia syndrome 22.21 10.74 53 242895 20529 42357858
Nephrotic syndrome 22.11 10.74 11 242937 8707 42369680
Encephalopathy neonatal 22.02 10.74 9 242939 43 42378344
Personality disorder 21.92 10.74 30 242918 1133 42377254
Quality of life decreased 21.89 10.74 74 242874 5302 42373085
Neoplasm progression 21.84 10.74 88 242860 28912 42349475
Thrombosis 21.81 10.74 528 242420 67983 42310404
Personality change 21.79 10.74 77 242871 5642 42372745
Stiff person syndrome 21.75 10.74 14 242934 194 42378193
Schizophrenia 21.66 10.74 17 242931 10533 42367854
Drug tolerance increased 21.54 10.74 19 242929 433 42377954
Neonatal toxicity 21.51 10.74 8 242940 28 42378359
Drug-induced liver injury 21.40 10.74 129 242819 38144 42340243
Mechanical ventilation complication 21.17 10.74 23 242925 681 42377706
Respiratory failure 21.16 10.74 562 242386 127570 42250817
Haemoglobin decreased 21.10 10.74 584 242364 131887 42246500
Abnormal behaviour 20.98 10.74 237 242711 26214 42352173
Nephropathy toxic 20.98 10.74 40 242908 16798 42361589
Stevens-Johnson syndrome 20.98 10.74 61 242887 22117 42356270
Head titubation 20.94 10.74 19 242929 450 42377937
Parosmia 20.79 10.74 93 242855 7598 42370789
Suicidal behaviour 20.72 10.74 34 242914 1512 42376875
Left ventricular dysfunction 20.66 10.74 21 242927 11480 42366907
Ventricular tachycardia 20.58 10.74 95 242853 30065 42348322
Phantom limb syndrome 20.54 10.74 15 242933 258 42378129
Diarrhoea 20.54 10.74 2307 240641 458542 41919845
Breakthrough pain 20.47 10.74 21 242927 581 42377806
Juvenile idiopathic arthritis 20.46 10.74 46 242902 2593 42375794
Anaphylactic reaction 20.42 10.74 151 242797 42592 42335795
Blood pressure systolic increased 20.35 10.74 86 242862 27882 42350505
Second primary malignancy 20.21 10.74 15 242933 9560 42368827
Uveitis 20.20 10.74 14 242934 9244 42369143
Metastases to liver 20.15 10.74 39 242909 16287 42362100
Tooth disorder 20.10 10.74 127 242821 11852 42366535
Peritonitis 20.10 10.74 48 242900 18585 42359802
Autoimmune haemolytic anaemia 19.97 10.74 4 242944 5667 42372720
Disease recurrence 19.95 10.74 94 242854 29584 42348803
Hypertriglyceridaemia 19.94 10.74 17 242931 10109 42368278
Transaminases increased 19.91 10.74 108 242840 32777 42345610
Stomatitis 19.87 10.74 187 242761 50142 42328245
Electrocardiogram QT prolonged 19.86 10.74 176 242772 47769 42330618
Platelet count decreased 19.81 10.74 620 242328 137961 42240426
Pseudomonas infection 19.68 10.74 38 242910 15885 42362502
Lumbar radiculopathy 19.59 10.74 24 242924 811 42377576
Drug withdrawal syndrome neonatal 19.59 10.74 63 242885 4398 42373989
Inflammatory marker increased 19.58 10.74 7 242941 6749 42371638
Impaired work ability 19.55 10.74 127 242821 11964 42366423
Facial wasting 19.49 10.74 11 242937 118 42378269
Amphetamines positive 19.43 10.74 13 242935 193 42378194
Neurogenic bladder 19.35 10.74 41 242907 2219 42376168
Ejection fraction decreased 19.29 10.74 63 242885 22024 42356363
Conjunctivitis allergic 19.16 10.74 5 242943 5906 42372481
Pulmonary tuberculosis 19.12 10.74 4 242944 5497 42372890
Foetal disorder 19.09 10.74 27 242921 1052 42377335
Catarrh 18.99 10.74 76 242872 5910 42372477
Off label use 18.97 10.74 3276 239672 635059 41743328
Liver disorder 18.96 10.74 140 242808 39504 42338883
Fungal infection 18.83 10.74 54 242894 19668 42358719
Drug screen negative 18.82 10.74 13 242935 204 42378183
Acute coronary syndrome 18.79 10.74 35 242913 14830 42363557
Distributive shock 18.79 10.74 43 242905 2453 42375934
Nausea 18.66 10.74 2557 240391 394242 41984145
Hypoalbuminaemia 18.65 10.74 38 242910 15572 42362815
Candida infection 18.62 10.74 62 242886 21548 42356839
Iron deficiency 18.39 10.74 117 242831 10944 42367443
Schizoaffective disorder 18.35 10.74 37 242911 1933 42376454
Congenital multiplex arthrogryposis 18.31 10.74 14 242934 259 42378128
Chest X-ray abnormal 18.31 10.74 62 242886 4446 42373941
Polyneuropathy in malignant disease 18.31 10.74 16 242932 360 42378027
Diffuse large B-cell lymphoma recurrent 18.17 10.74 3 242945 4883 42373504
Hypopnoea 18.16 10.74 91 242857 7791 42370596
Mucormycosis 18.13 10.74 9 242939 7134 42371253
Adverse reaction 18.09 10.74 57 242891 3936 42374451
Blood creatine phosphokinase increased 18.08 10.74 182 242766 48156 42330231
Impaired driving ability 18.08 10.74 47 242901 2908 42375479
Opisthotonus 17.83 10.74 20 242928 614 42377773
Mucosal atrophy 17.78 10.74 9 242939 76 42378311
Musculoskeletal disorder 17.74 10.74 80 242868 6558 42371829
Graft versus host disease in skin 17.69 10.74 4 242944 5208 42373179
Neutrophil count increased 17.64 10.74 56 242892 19748 42358639
Lymphocyte count decreased 17.58 10.74 90 242858 27719 42350668
Hepatitis 17.46 10.74 88 242860 27212 42351175
Alcohol interaction 17.44 10.74 38 242910 2097 42376290
Ear deformity acquired 17.43 10.74 5 242943 5 42378382
Shock haemorrhagic 17.39 10.74 42 242906 16200 42362187
Foetal exposure during pregnancy 17.33 10.74 179 242769 47132 42331255
Encephalitis 17.28 10.74 16 242932 9142 42369245
Hypocalcaemia 17.24 10.74 101 242847 30072 42348315
Osteomyelitis 17.14 10.74 169 242779 18054 42360333
Chorea 17.03 10.74 30 242918 1414 42376973
Ventricular hypokinesia 16.99 10.74 9 242939 6875 42371512
Alcohol withdrawal syndrome 16.93 10.74 30 242918 1421 42376966
Nerve compression 16.89 10.74 56 242892 3972 42374415
Radiculopathy 16.87 10.74 48 242900 3132 42375255
Enterocolitis 16.86 10.74 19 242929 9910 42368477
Needle track marks 16.83 10.74 8 242940 58 42378329
Violence-related symptom 16.81 10.74 18 242930 524 42377863
Nephrogenic systemic fibrosis 16.81 10.74 51 242897 3450 42374937
Bladder cancer 16.78 10.74 46 242902 17001 42361386
Intentional underdose 16.70 10.74 21 242927 729 42377658
Idiopathic neutropenia 16.69 10.74 4 242944 0 42378387
Opiates positive 16.68 10.74 18 242930 529 42377858
Adenovirus infection 16.66 10.74 9 242939 6800 42371587
Anorgasmia 16.60 10.74 26 242922 1111 42377276
Gout 16.56 10.74 238 242710 27817 42350570
Drug abuser 16.55 10.74 51 242897 3480 42374907
Precancerous skin lesion 16.49 10.74 19 242929 601 42377786
Haematochezia 16.49 10.74 234 242714 58202 42320185
Immunosuppressant drug level increased 16.46 10.74 12 242936 7719 42370668
Hepatitis fulminant 16.45 10.74 4 242944 4955 42373432
Tuberculosis 16.43 10.74 20 242928 10079 42368308
Tracheobronchitis bacterial 16.25 10.74 7 242941 39 42378348
Blood cholesterol increased 16.25 10.74 228 242720 26513 42351874
Spinal stenosis 16.23 10.74 76 242872 6330 42372057
Hyperthyroidism 16.23 10.74 36 242912 14305 42364082
Chronic graft versus host disease 16.21 10.74 7 242941 6018 42372369
Cerebral disorder 16.15 10.74 46 242902 3004 42375383
Muscular weakness 16.13 10.74 605 242343 82893 42295494
Brief psychotic disorder with marked stressors 16.11 10.74 13 242935 261 42378126
Tinnitus 16.11 10.74 243 242705 28695 42349692
Back injury 16.10 10.74 58 242890 4290 42374097
Pneumonia fungal 16.09 10.74 17 242931 9129 42369258
Epistaxis 16.02 10.74 276 242672 66550 42311837
Blood pressure fluctuation 15.95 10.74 89 242859 26819 42351568
Pseudostroke 15.91 10.74 9 242939 97 42378290
Endophthalmitis 15.88 10.74 3 242945 4430 42373957
Congenital megacolon 15.86 10.74 8 242940 67 42378320
Respiratory syncytial virus bronchitis 15.84 10.74 9 242939 98 42378289
Muscular dystrophy 15.82 10.74 10 242938 134 42378253
Hypotension 15.81 10.74 1259 241689 256372 42122015
Cholestasis 15.78 10.74 116 242832 32763 42345624
Anticipatory anxiety 15.72 10.74 6 242942 23 42378364
Pneumonia bacterial 15.70 10.74 42 242906 15650 42362737
Cardiac failure chronic 15.63 10.74 19 242929 9582 42368805
Malignant catatonia 15.59 10.74 16 242932 443 42377944
Malaise 15.56 10.74 1021 241927 211135 42167252
Hyperthermia 15.55 10.74 30 242918 12544 42365843
Sleep attacks 15.51 10.74 10 242938 139 42378248
Aggression 15.49 10.74 345 242603 43818 42334569
Duodenal ulcer 15.44 10.74 29 242919 12250 42366137
Gingival atrophy 15.43 10.74 7 242941 45 42378342
Nocturia 15.38 10.74 120 242828 11992 42366395
Degenerative bone disease 15.37 10.74 8 242940 72 42378315
Arteriospasm coronary 15.37 10.74 4 242944 4734 42373653
Cardiogenic shock 15.33 10.74 287 242661 35353 42343034
Thinking abnormal 15.33 10.74 81 242867 7080 42371307
Cardiomyopathy 15.29 10.74 57 242891 19153 42359234
Intestinal perforation 15.22 10.74 24 242924 10850 42367537
Hypernatraemia 15.15 10.74 21 242927 10011 42368376
Decreased appetite 15.11 10.74 924 242024 192213 42186174
Spinal fusion surgery 15.10 10.74 26 242922 1203 42377184
Sleep disorder due to a general medical condition 15.09 10.74 50 242898 17403 42360984
Hypertonia neonatal 15.07 10.74 18 242930 592 42377795
Retinal haemorrhage 15.06 10.74 7 242941 5763 42372624
Mouth ulceration 15.01 10.74 40 242908 14923 42363464
Headache 14.99 10.74 1571 241377 237798 42140589
Feeling drunk 14.94 10.74 37 242911 2221 42376166
Oesophageal carcinoma 14.94 10.74 20 242928 9676 42368711
Vertigo 14.92 10.74 277 242671 34070 42344317
Muscle tightness 14.90 10.74 67 242881 5486 42372901
Hyperkalaemia 14.87 10.74 347 242601 80111 42298276
Clonus 14.82 10.74 49 242899 3471 42374916
Forced expiratory volume decreased 14.80 10.74 13 242935 7617 42370770
Neutropenia neonatal 14.79 10.74 22 242926 898 42377489
Dysphoria 14.79 10.74 42 242906 2738 42375649
Slow speech 14.78 10.74 32 242916 1758 42376629
Tachycardia 14.75 10.74 451 242497 100636 42277751
Conversion disorder 14.63 10.74 17 242931 543 42377844
Localised infection 14.59 10.74 179 242769 20194 42358193
Erysipelas 14.44 10.74 9 242939 6287 42372100
Large intestine perforation 14.36 10.74 20 242928 9516 42368871
Panic attack 14.34 10.74 110 242838 10935 42367452
Gastric cancer 14.33 10.74 11 242937 6892 42371495
Neutropenic sepsis 14.26 10.74 45 242903 15901 42362486
Postmortem blood drug level 14.26 10.74 10 242938 161 42378226
Respiratory disorder 14.23 10.74 71 242877 22014 42356373
Bacteraemia 14.21 10.74 84 242864 24956 42353431
Central nervous system lesion 14.19 10.74 85 242863 7785 42370602
Skin toxicity 14.16 10.74 10 242938 6539 42371848
Bradykinesia 14.14 10.74 65 242883 5371 42373016
Neuritis 14.12 10.74 9 242939 6211 42372176
Neutropenic colitis 14.07 10.74 4 242944 4466 42373921
Haemoptysis 14.06 10.74 182 242766 45985 42332402
Surgery 14.04 10.74 158 242790 17458 42360929
Neurological symptom 14.03 10.74 22 242926 9969 42368418
White blood cell count increased 14.01 10.74 177 242771 44910 42333477
Loss of proprioception 14.00 10.74 15 242933 437 42377950
Rhabdomyolysis 14.00 10.74 338 242610 77681 42300706
Enthesopathy 13.99 10.74 5 242943 4823 42373564
Oxygen saturation decreased 13.99 10.74 272 242676 64415 42313972
Head injury 13.95 10.74 179 242769 20403 42357984
Seizure 13.94 10.74 830 242118 119731 42258656
Fear of weight gain 13.94 10.74 4 242944 4 42378383
Progressive multifocal leukoencephalopathy 13.86 10.74 28 242920 11508 42366879
Coagulopathy 13.85 10.74 72 242876 22090 42356297
Fungating wound 13.74 10.74 7 242941 60 42378327
Diabetic foot infection 13.70 10.74 19 242929 727 42377660
Steroid dependence 13.69 10.74 75 242873 6647 42371740
Movement disorder 13.67 10.74 136 242812 14562 42363825
Product taste abnormal 13.67 10.74 25 242923 1214 42377173
Blood alkaline phosphatase increased 13.62 10.74 124 242824 33473 42344914
Emotional distress 13.59 10.74 146 242802 15947 42362440
Oesophageal mucosa erythema 13.57 10.74 6 242942 36 42378351
Post herpetic neuralgia 13.56 10.74 25 242923 1221 42377166
Accidental overdose 13.56 10.74 232 242716 28098 42350289
Abnormal labour affecting foetus 13.55 10.74 5 242943 17 42378370
Abdominal discomfort 13.53 10.74 541 242407 74714 42303673
Hyperglycaemia 13.52 10.74 182 242766 45677 42332710
Dysphemia 13.48 10.74 32 242916 1870 42376517
Arrhythmia 13.39 10.74 156 242792 40161 42338226
Respiratory rate decreased 13.31 10.74 42 242906 2903 42375484
Kidney transplant rejection 13.29 10.74 18 242930 8665 42369722
Gastrointestinal adenocarcinoma 13.27 10.74 7 242941 65 42378322
Organising pneumonia 13.25 10.74 14 242934 7518 42370869
Infective pulmonary exacerbation of cystic fibrosis 13.23 10.74 15 242933 7803 42370584
Complications of transplanted kidney 13.20 10.74 7 242941 5343 42373044
Brain abscess 13.18 10.74 4 242944 4280 42374107
Immune-mediated enterocolitis 13.18 10.74 8 242940 5669 42372718
Heat exhaustion 13.17 10.74 10 242938 183 42378204
Affective disorder 13.16 10.74 68 242880 5892 42372495
Lymphadenopathy 13.16 10.74 124 242824 33241 42345146
Alcohol poisoning 13.14 10.74 81 242867 7493 42370894
Erythema multiforme 13.05 10.74 23 242925 9954 42368433
Haemorrhage intracranial 13.05 10.74 52 242896 17140 42361247
Rheumatoid arthritis 13.04 10.74 167 242781 42273 42336114
Abnormal sleep-related event 13.01 10.74 15 242933 475 42377912
Implant site inflammation 13.00 10.74 8 242940 102 42378285
Hypersomnia 12.99 10.74 134 242814 14484 42363903
Cytomegalovirus chorioretinitis 12.99 10.74 5 242943 4606 42373781
Blood creatinine increased 12.98 10.74 504 242444 109499 42268888
Therapeutic response unexpected 12.96 10.74 110 242838 11271 42367116
Free androgen index decreased 12.93 10.74 5 242943 20 42378367
Major depression 12.92 10.74 63 242885 5335 42373052
Blood urea increased 12.88 10.74 122 242826 32671 42345716
Intervertebral disc injury 12.74 10.74 5 242943 21 42378366
Electrocardiogram abnormal 12.72 10.74 24 242924 10121 42368266
Portal vein thrombosis 12.70 10.74 5 242943 4544 42373843
Infection 12.67 10.74 516 242432 111552 42266835
Sedation complication 12.62 10.74 41 242907 2878 42375509
Benign neoplasm of spinal cord 12.52 10.74 3 242945 0 42378387
Nasal odour 12.52 10.74 3 242945 0 42378387
Atrioventricular block complete 12.47 10.74 29 242919 11335 42367052
Mental impairment 12.46 10.74 116 242832 12201 42366186
Blood pressure decreased 12.39 10.74 246 242702 58086 42320301
Cyanosis 12.36 10.74 44 242904 14987 42363400
Anal abscess 12.29 10.74 16 242932 7834 42370553
Abnormal dreams 12.25 10.74 85 242863 8186 42370201
Weight increased 12.22 10.74 742 242206 107241 42271146
Post laminectomy syndrome 12.22 10.74 10 242938 205 42378182
Systemic lupus erythematosus 12.19 10.74 93 242855 9231 42369156
Body height decreased 12.17 10.74 51 242897 4049 42374338
Impaired quality of life 12.15 10.74 129 242819 14048 42364339
Polyarthritis 12.12 10.74 7 242941 5097 42373290
Hyperuricaemia 12.08 10.74 22 242926 9402 42368985
Dyspnoea exertional 12.05 10.74 207 242741 49941 42328446
Rib fracture 12.04 10.74 146 242802 16425 42361962
Ventricular septal defect 12.01 10.74 5 242943 4394 42373993
Pericarditis 11.98 10.74 38 242910 13406 42364981
Electric shock 11.98 10.74 9 242939 162 42378225
Incorrect route of product administration 11.98 10.74 200 242748 24105 42354282
Conjunctivitis 11.94 10.74 36 242912 12903 42365484
Product administration interrupted 11.91 10.74 58 242890 4908 42373479
Foot fracture 11.89 10.74 68 242880 6123 42372264
Virologic failure 11.81 10.74 4 242944 3990 42374397
Developmental hip dysplasia 11.79 10.74 12 242936 329 42378058
Blood pressure diastolic decreased 11.78 10.74 26 242922 10349 42368038
Cytomegalovirus colitis 11.75 10.74 4 242944 3977 42374410
Teeth brittle 11.72 10.74 6 242942 52 42378335
Joint hyperextension 11.72 10.74 8 242940 123 42378264
Bipolar I disorder 11.68 10.74 19 242929 839 42377548
Blood ethanol 11.66 10.74 7 242941 85 42378302
Antipsychotic drug level increased 11.66 10.74 6 242942 4660 42373727
Systemic candida 11.66 10.74 8 242940 5311 42373076
Cytomegalovirus test positive 11.65 10.74 5 242943 4314 42374073
Respiratory tract infection 11.63 10.74 95 242853 26227 42352160
Multiple cardiac defects 11.63 10.74 6 242942 53 42378334
Hypometabolism 11.61 10.74 9 242939 170 42378217
Irregular sleep phase 11.61 10.74 8 242940 125 42378262
Metabolic encephalopathy 11.58 10.74 60 242888 5205 42373182
Antidepressant drug level increased 11.55 10.74 10 242938 222 42378165
Leukopenia 11.52 10.74 331 242617 74415 42303972
Diplopia 11.46 10.74 171 242777 20145 42358242
Drug dose omission by device 11.45 10.74 10 242938 5876 42372511
Aphasia 11.44 10.74 197 242751 23886 42354501
Alanine aminotransferase abnormal 11.43 10.74 7 242941 4937 42373450
Sleep deficit 11.41 10.74 20 242928 939 42377448
Multiple-drug resistance 11.39 10.74 15 242933 7307 42371080
Decreased interest 11.37 10.74 38 242910 2707 42375680
Oropharyngeal oedema 11.32 10.74 7 242941 90 42378297
Osteonecrosis of jaw 11.29 10.74 63 242885 18986 42359401
Hip fracture 11.27 10.74 122 242826 13350 42365037
Anaphylactic shock 11.27 10.74 83 242865 23434 42354953
Antacid therapy 11.25 10.74 55 242893 4662 42373725
Arterial therapeutic procedure 11.22 10.74 4 242944 12 42378375
Psychiatric decompensation 11.21 10.74 5 242943 4217 42374170
Complex regional pain syndrome 11.21 10.74 16 242932 629 42377758
Systemic infection 11.19 10.74 8 242940 5197 42373190
Feeling jittery 11.13 10.74 53 242895 4445 42373942
Staphylococcal sepsis 11.08 10.74 31 242917 11383 42367004
Bronchospasm 11.08 10.74 37 242911 12848 42365539
Diastolic dysfunction 11.08 10.74 73 242875 6910 42371477
Red blood cell sedimentation rate abnormal 11.07 10.74 4 242944 3832 42374555
Lymphoma 11.07 10.74 43 242905 14278 42364109
Asphyxia 11.07 10.74 19 242929 8307 42370080
Mental disorder 11.06 10.74 154 242794 17875 42360512
Rales 11.04 10.74 31 242917 11369 42367018
Device related infection 11.00 10.74 69 242879 20210 42358177
Arthrofibrosis 10.99 10.74 6 242942 60 42378327
Feeding intolerance 10.97 10.74 11 242937 296 42378091
Haemorrhage 10.96 10.74 262 242686 60301 42318086
Nitrite urine present 10.88 10.74 10 242938 241 42378146
Term birth 10.87 10.74 7 242941 97 42378290
Lymphopenia 10.87 10.74 75 242873 21488 42356899
Crying 10.86 10.74 68 242880 6326 42372061
Normochromic normocytic anaemia 10.78 10.74 22 242926 9009 42369378
Ventricular fibrillation 10.77 10.74 236 242712 29887 42348500
Chest discomfort 10.76 10.74 278 242670 63338 42315049
Neck surgery 10.74 10.74 14 242934 504 42377883
Panic disorder 10.74 10.74 23 242925 1254 42377133

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 3035.53 9.79 4789 545047 237592 109801871
Drug hypersensitivity 1876.45 9.79 5731 544105 448359 109591104
Drug ineffective for unapproved indication 1117.64 9.79 1908 547928 100930 109938533
Toxicity to various agents 1075.16 9.79 4983 544853 475572 109563891
Pemphigus 1001.98 9.79 12 549824 214558 109824905
Myoclonus 879.52 9.79 948 548888 32050 110007413
Somnolence 861.46 9.79 3338 546498 294111 109745352
Anti-cyclic citrullinated peptide antibody positive 855.04 9.79 9 549827 181975 109857488
Duodenal ulcer perforation 829.38 9.79 10 549826 177690 109861773
Hand deformity 825.38 9.79 70 549766 218436 109821027
Synovitis 789.86 9.79 195 549641 273897 109765566
Glossodynia 781.63 9.79 93 549743 221911 109817552
Pericarditis 775.89 9.79 90 549746 219024 109820439
Helicobacter infection 756.15 9.79 35 549801 181842 109857621
Drug abuse 735.09 9.79 2244 547592 175167 109864296
Systemic lupus erythematosus 655.56 9.79 223 549613 254115 109785348
Folliculitis 600.71 9.79 66 549770 167587 109871876
Rheumatoid factor positive 587.04 9.79 14 549822 131626 109907837
Muscle injury 585.59 9.79 27 549809 140780 109898683
Multiple sclerosis relapse 577.34 9.79 956 548880 49284 109990179
Maternal exposure during pregnancy 574.52 9.79 274 549562 254609 109784854
Fall 551.85 9.79 4989 544847 598493 109440970
Rheumatic fever 514.69 9.79 22 549814 122557 109916906
Wound 474.26 9.79 289 549547 234148 109805315
C-reactive protein abnormal 462.23 9.79 52 549784 129643 109909820
Irritable bowel syndrome 442.54 9.79 133 549703 164082 109875381
Respiratory arrest 433.97 9.79 921 548915 57378 109982085
Sleep disorder due to general medical condition, insomnia type 433.67 9.79 22 549814 105621 109933842
Arthropathy 433.11 9.79 474 549362 287048 109752415
Infusion related reaction 423.80 9.79 780 549056 380382 109659081
C-reactive protein increased 422.48 9.79 282 549554 217637 109821826
Hepatic enzyme increased 405.65 9.79 604 549232 320288 109719175
Drug withdrawal syndrome 398.70 9.79 695 549141 37359 110002104
Impaired healing 398.56 9.79 242 549594 196475 109842988
Swollen joint count increased 398.31 9.79 3 549833 83658 109955805
Drug dependence 382.52 9.79 799 549037 49221 109990242
Tremor 381.07 9.79 1999 547837 200233 109839230
Breast cancer stage III 371.14 9.79 4 549832 79113 109960350
Sedation 364.19 9.79 959 548877 68724 109970739
Liver injury 358.79 9.79 149 549687 150264 109889199
Facet joint syndrome 354.85 9.79 35 549801 96793 109942670
Suicidal ideation 354.63 9.79 1151 548685 92786 109946677
Lip dry 349.50 9.79 43 549793 100040 109939423
General physical health deterioration 349.09 9.79 1024 548812 424271 109615192
Withdrawal syndrome 336.44 9.79 579 549257 30801 110008662
Mental status changes 328.34 9.79 977 548859 75145 109964318
Type 2 diabetes mellitus 328.10 9.79 241 549595 176991 109862472
Contraindicated product administered 326.81 9.79 454 549382 247813 109791650
Feeling abnormal 316.48 9.79 1751 548085 178960 109860503
Myelosuppression 311.79 9.79 48 549788 94292 109945171
Lower respiratory tract infection 302.88 9.79 462 549374 242644 109796819
Cardio-respiratory arrest 300.45 9.79 1257 548579 114579 109924884
Ill-defined disorder 292.01 9.79 212 549624 156641 109882822
Psoriatic arthropathy 291.13 9.79 329 549507 196432 109843031
Hallucination 290.38 9.79 1135 548701 100297 109939166
Joint swelling 273.14 9.79 1202 548634 441643 109597820
Multiple sclerosis 272.67 9.79 472 549364 25226 110014237
Therapeutic product effect decreased 261.69 9.79 511 549325 243805 109795658
Depression 258.18 9.79 2561 547275 314774 109724689
Balance disorder 250.41 9.79 1196 548640 115364 109924099
Peripheral venous disease 249.74 9.79 56 549780 84061 109955402
Discomfort 249.62 9.79 427 549409 214280 109825183
Stomatitis 249.26 9.79 614 549222 269628 109769835
Respiratory depression 249.14 9.79 515 549321 31486 110007977
Nightmare 248.69 9.79 578 549258 38285 110001178
Intentional product misuse 248.36 9.79 1311 548525 131593 109907870
Live birth 237.42 9.79 32 549804 69452 109970011
Dizziness 227.87 9.79 4798 545038 693395 109346068
Neuralgia 226.17 9.79 640 549196 47838 109991625
Accidental death 225.08 9.79 192 549644 4817 110034646
Overdose 224.39 9.79 1955 547881 231839 109807624
Blister 222.13 9.79 501 549335 226875 109812588
Interstitial lung disease 214.92 9.79 225 549611 139109 109900354
Suspected suicide 214.60 9.79 318 549518 14881 110024582
Inflammation 212.30 9.79 398 549438 192840 109846623
Vision blurred 211.86 9.79 1229 548607 127793 109911670
Hypercholesterolaemia 207.09 9.79 96 549740 90741 109948722
Wheezing 206.72 9.79 618 549218 254612 109784851
Cardiac arrest 206.69 9.79 1679 548157 195074 109844389
Product dose omission issue 204.15 9.79 2472 547364 319310 109720153
Sopor 201.25 9.79 513 549323 36033 110003430
Alopecia 196.89 9.79 1038 548798 363715 109675748
Death 195.13 9.79 4698 545138 694171 109345292
Lung disorder 195.01 9.79 374 549462 179673 109859790
Hypersensitivity 194.70 9.79 1193 548643 402805 109636658
Joint range of motion decreased 194.44 9.79 191 549645 121641 109917822
Back pain 193.96 9.79 2751 547085 368245 109671218
Injury 191.31 9.79 369 549467 176896 109862567
Dislocation of vertebra 186.37 9.79 7 549829 43714 109995749
Febrile neutropenia 182.59 9.79 881 548955 315886 109723577
Lethargy 182.36 9.79 934 548902 92642 109946821
Pulmonary fibrosis 180.86 9.79 145 549691 101897 109937566
Hyperhidrosis 178.01 9.79 1563 548273 185735 109853728
Depressed level of consciousness 176.90 9.79 1058 548778 111220 109928243
Exposure during pregnancy 176.80 9.79 353 549483 167071 109872392
Pyrexia 174.00 9.79 3283 546553 894982 109144481
Autoimmune disorder 172.84 9.79 55 549781 65428 109974035
Serotonin syndrome 172.59 9.79 666 549170 58487 109980976
Swelling 171.01 9.79 1033 548803 350008 109689455
Blepharospasm 170.07 9.79 33 549803 54818 109984645
Bone erosion 169.27 9.79 17 549819 46354 109993109
Wound infection 168.57 9.79 139 549697 96326 109943137
Grip strength decreased 167.46 9.79 95 549741 80079 109959384
Adjustment disorder with depressed mood 165.77 9.79 14 549822 43869 109995594
Cytomegalovirus infection 164.14 9.79 35 549801 54409 109985054
X-ray abnormal 162.83 9.79 6 549830 38111 110001352
Night sweats 160.74 9.79 261 549575 133722 109905741
Gastrointestinal disorder 159.36 9.79 640 549196 241312 109798151
Onychomadesis 158.48 9.79 20 549816 45643 109993820
Blood cholesterol increased 157.97 9.79 436 549400 184349 109855114
Hepatic function abnormal 156.86 9.79 128 549708 89167 109950296
Abdominal discomfort 156.72 9.79 1230 548606 392628 109646835
Urinary tract infection 153.85 9.79 2377 547459 323905 109715558
Neuropathy peripheral 152.09 9.79 1460 548376 177817 109861646
Pain in extremity 151.40 9.79 3325 546511 483793 109555670
Nail disorder 150.54 9.79 50 549786 57885 109981578
Mobility decreased 145.87 9.79 645 549191 236777 109802686
Retinitis 145.81 9.79 3 549833 32324 110007139
Seizure 145.37 9.79 1711 548125 219474 109819989
Gait disturbance 140.15 9.79 2050 547786 276158 109763305
Anxiety 138.34 9.79 2448 547388 342630 109696833
Constipation 138.09 9.79 2523 547313 355263 109684200
Fibromyalgia 135.36 9.79 418 549418 170491 109868972
Dyskinesia 134.69 9.79 560 549276 50886 109988577
Nasopharyngitis 133.15 9.79 1285 548551 393076 109646387
Sleep apnoea syndrome 128.47 9.79 468 549368 39979 109999484
Ataxia 125.61 9.79 382 549454 29726 110009737
Fatigue 124.76 9.79 7307 542529 1208651 108830812
Drug-induced liver injury 122.63 9.79 258 549578 119809 109919654
Intentional product use issue 121.99 9.79 727 549109 247179 109792284
Sinusitis 120.57 9.79 921 548915 295767 109743696
Inspiratory capacity decreased 119.74 9.79 101 549735 2494 110036969
Plasma cell myeloma 119.71 9.79 624 549212 62312 109977151
Dysarthria 118.92 9.79 771 549065 83350 109956113
Hallucination, visual 114.79 9.79 445 549391 39160 110000303
Irritability 114.06 9.79 506 549330 47303 109992160
Stress 113.28 9.79 904 548932 104444 109935019
Burning sensation 109.52 9.79 653 549183 68559 109970904
Breast cancer stage II 108.35 9.79 7 549829 27368 110012095
Euphoric mood 108.20 9.79 173 549663 8654 110030809
Mental disorder 106.89 9.79 429 549407 38362 110001101
Confusional state 105.23 9.79 3063 546773 465617 109573846
Inadequate analgesia 105.06 9.79 128 549708 4949 110034514
Lupus-like syndrome 104.60 9.79 36 549800 40756 109998707
Liver disorder 104.24 9.79 360 549476 141883 109897580
Agitation 104.06 9.79 937 548899 112114 109927349
Drug resistance 103.84 9.79 77 549759 56297 109983166
Pregnancy 103.12 9.79 63 549773 51004 109988459
Urinary incontinence 101.03 9.79 494 549342 48093 109991370
Unresponsive to stimuli 100.39 9.79 601 549235 63189 109976274
Lower limb fracture 99.86 9.79 137 549699 75211 109964252
Urticaria 99.71 9.79 1058 548778 317799 109721664
Appendicolith 98.96 9.79 219 549617 14036 110025427
Head injury 97.18 9.79 448 549388 42569 109996894
Hyperaesthesia 96.38 9.79 221 549615 14506 110024957
Product complaint 96.26 9.79 214 549622 13758 110025705
Obesity 95.70 9.79 269 549567 113082 109926381
Taste disorder 94.86 9.79 111 549725 65276 109974187
Infection 94.72 9.79 1250 548586 360950 109678513
Mood altered 93.71 9.79 276 549560 21099 110018364
Speech disorder 90.54 9.79 570 549266 60999 109978464
Bursitis 89.77 9.79 337 549499 129581 109909882
Muscle twitching 89.75 9.79 340 549496 29595 110009868
Mucosal inflammation 88.91 9.79 218 549618 95923 109943540
Crying 88.66 9.79 305 549531 25323 110014140
Onychomycosis 87.38 9.79 41 549795 38490 110000973
Cardiac failure 85.68 9.79 563 549273 187063 109852400
Maternal exposure timing unspecified 84.29 9.79 5 549831 21008 110018455
Disorientation 84.09 9.79 621 549215 70050 109969413
Spinal operation 83.55 9.79 175 549661 10797 110028666
Nervousness 83.40 9.79 384 549452 36467 110002996
Accidental overdose 82.62 9.79 490 549346 51344 109988119
Vertigo 82.51 9.79 725 549111 86145 109953318
Nausea 82.28 9.79 7170 542666 1228520 108810943
Bone marrow failure 82 9.79 100 549736 57748 109981715
Intervertebral disc degeneration 81.66 9.79 236 549600 17849 110021614
Drug use disorder 80.79 9.79 235 549601 17839 110021624
Porphyria acute 80.07 9.79 3 549833 18777 110020686
Asterixis 79.38 9.79 88 549748 3070 110036393
Therapeutic response unexpected 78.37 9.79 279 549557 23564 110015899
Red blood cell sedimentation rate increased 77.67 9.79 171 549665 78131 109961332
Prescription drug used without a prescription 77.60 9.79 115 549721 5381 110034082
Epilepsy 75.20 9.79 251 549585 99958 109939505
Anaemia 74.78 9.79 2109 547727 544977 109494486
Cytomegalovirus infection reactivation 74.65 9.79 4 549832 18329 110021134
Disturbance in attention 74.47 9.79 546 549290 61449 109978014
Encephalopathy 73.15 9.79 669 549167 80386 109959077
Drug tolerance decreased 72.91 9.79 23 549813 27517 110011946
Intervertebral disc protrusion 72.89 9.79 302 549534 27396 110012067
Product label confusion 71.67 9.79 13 549823 22664 110016799
Neutropenia 71.38 9.79 1372 548464 373248 109666215
Memory impairment 70.79 9.79 1374 548462 195570 109843893
Pneumocystis jirovecii pneumonia 70.51 9.79 65 549771 42670 109996793
Surgery 70.18 9.79 397 549439 40886 109998577
Right atrial hypertrophy 69.10 9.79 43 549793 648 110038815
Intentional overdose 67.70 9.79 979 548857 131522 109907941
Hypersomnia 67.70 9.79 298 549538 27763 110011700
Dissociation 66.97 9.79 150 549686 9692 110029771
Appendicitis 66.95 9.79 300 549536 28164 110011299
Anticipatory anxiety 66.59 9.79 53 549783 1203 110038260
Muscle spasms 66.27 9.79 1832 548004 276325 109763138
Restless legs syndrome 65.98 9.79 270 549566 24356 110015107
Joint injury 65.63 9.79 381 549455 39613 109999850
Coma 64.69 9.79 882 548954 116987 109922476
Colitis 64.62 9.79 275 549561 102048 109937415
Malignant neoplasm progression 64.41 9.79 556 549280 174011 109865452
Diplopia 63.56 9.79 391 549445 41503 109997960
Thrombocytopenia 63.37 9.79 1288 548548 347597 109691866
Pancytopenia 63.29 9.79 701 549135 208912 109830551
Rheumatoid arthritis 63.14 9.79 1078 548758 298535 109740928
Hip arthroplasty 63.00 9.79 113 549723 55700 109983763
Drug intolerance 62.93 9.79 1539 548297 404973 109634490
Trigeminal neuralgia 62.80 9.79 92 549744 4260 110035203
Oedema 62.70 9.79 704 549132 209272 109830191
Feeling drunk 62.28 9.79 104 549732 5396 110034067
Haemophagocytic lymphohistiocytosis 62.25 9.79 40 549796 31519 110007944
Anger 62.12 9.79 222 549614 18785 110020678
Dysstasia 61.31 9.79 325 549511 32661 110006802
Hepatic cirrhosis 61.23 9.79 155 549681 67471 109971992
Bradyphrenia 60.84 9.79 161 549675 11567 110027896
Therapeutic product effect variable 60.31 9.79 71 549765 2647 110036816
Liver function test increased 59.67 9.79 232 549604 88316 109951147
Chorea 59.67 9.79 77 549759 3158 110036305
Hepatitis 59.38 9.79 238 549598 89816 109949647
Obsessive-compulsive disorder 59.28 9.79 119 549717 7122 110032341
Musculoskeletal pain 58.92 9.79 603 549233 182420 109857043
Treatment failure 58.89 9.79 996 548840 276238 109763225
Gait spastic 58.87 9.79 54 549782 1495 110037968
Device expulsion 58.45 9.79 41 549795 30850 110008613
Loss of consciousness 57.71 9.79 1330 548506 194976 109844487
Suicide attempt 57.69 9.79 776 549060 102618 109936845
Rash 57.38 9.79 3419 546417 817545 109221918
Tinnitus 57.35 9.79 505 549331 60035 109979428
Headache 57.33 9.79 5112 544724 877265 109162198
Prescribed underdose 57.00 9.79 152 549684 65022 109974441
Dyspepsia 56.33 9.79 642 549194 190323 109849140
Post transplant lymphoproliferative disorder 56.27 9.79 6 549830 15607 110023856
Sciatica 56.11 9.79 252 549584 92147 109947316
Thrombotic microangiopathy 56.07 9.79 38 549798 29111 110010352
Stiff person syndrome 55.92 9.79 37 549799 623 110038840
Cytokine release syndrome 55.61 9.79 172 549664 70134 109969329
Aspergillus infection 55.46 9.79 29 549807 25587 110013876
Presbyacusis 55.00 9.79 69 549767 2750 110036713
Temperature regulation disorder 54.69 9.79 164 549672 12662 110026801
Relapsing-remitting multiple sclerosis 54.04 9.79 59 549777 2023 110037440
Urinary retention 53.97 9.79 557 549279 69126 109970337
Foetal death 53.81 9.79 189 549647 15856 110023607
Impaired driving ability 53.73 9.79 106 549730 6264 110033199
Poisoning 53.57 9.79 286 549550 28819 110010644
Knee arthroplasty 53.44 9.79 156 549680 64792 109974671
Normal newborn 53.31 9.79 21 549815 21875 110017588
Hepatotoxicity 53.11 9.79 151 549685 63249 109976214
Panic attack 53.01 9.79 284 549552 28656 110010807
Osteoarthritis 52.68 9.79 617 549219 182006 109857457
Bradypnoea 52.46 9.79 126 549710 8523 110030940
Laryngitis 52.38 9.79 81 549755 42330 109997133
Micturition urgency 51.90 9.79 212 549624 19108 110020355
Acute graft versus host disease 51.86 9.79 3 549833 12878 110026585
Neovascularisation 51.80 9.79 53 549783 1684 110037779
Cellulitis 51.49 9.79 897 548939 125119 109914344
Musculoskeletal stiffness 50.80 9.79 1033 548803 278789 109760674
Hypertonic bladder 50.61 9.79 93 549743 5209 110034254
Burns second degree 50.55 9.79 116 549720 7617 110031846
Hyperreflexia 50.01 9.79 131 549705 9354 110030109
Needle fatigue 49.87 9.79 45 549791 1219 110038244
Drug reaction with eosinophilia and systemic symptoms 49.79 9.79 224 549612 81871 109957592
Full blood count decreased 49.59 9.79 301 549535 31798 110007665
Insomnia 49.39 9.79 2229 547607 358361 109681102
Diabetic neuropathy 49.12 9.79 108 549728 6891 110032572
Blood lactate dehydrogenase increased 48.93 9.79 91 549745 44243 109995220
Muscle tightness 48.74 9.79 173 549663 14589 110024874
Complex regional pain syndrome 48.74 9.79 60 549776 2345 110037118
Cytomegalovirus viraemia 48.54 9.79 14 549822 17750 110021713
Pulmonary toxicity 48.46 9.79 14 549822 17732 110021731
Limb injury 48.41 9.79 337 549499 37299 110002164
Antipsychotic drug level below therapeutic 48.26 9.79 51 549785 1684 110037779
Fluid retention 47.85 9.79 696 549140 93611 109945852
Therapy cessation 47.70 9.79 384 549452 44473 109994990
Transplant rejection 47.29 9.79 32 549804 24535 110014928
Nephrolithiasis 46.96 9.79 520 549316 65692 109973771
Rheumatoid nodule 46.95 9.79 21 549815 20275 110019188
Pleural fibrosis 46.84 9.79 80 549756 4228 110035235
Food allergy 46.73 9.79 210 549626 19738 110019725
Dysphemia 46.60 9.79 77 549759 3960 110035503
Abnormal behaviour 46.41 9.79 343 549493 38696 110000767
Hostility 46.36 9.79 62 549774 2634 110036829
Cerebrovascular accident 46.31 9.79 1205 548631 180079 109859384
Bronchopulmonary aspergillosis 46.28 9.79 48 549788 29815 110009648
Pain 46.02 9.79 5421 544415 949534 109089929
Alcoholism 45.91 9.79 73 549763 3634 110035829
Septic shock 45.90 9.79 531 549305 156997 109882466
Thrombosis 45.67 9.79 777 549059 107885 109931578
Respiratory disorder 45.59 9.79 191 549645 71191 109968272
Disseminated intravascular coagulation 45.34 9.79 85 549751 41201 109998262
Lymphoedema 45.11 9.79 170 549666 14759 110024704
Disinhibition 44.86 9.79 66 549770 3068 110036395
Ankle fracture 44.46 9.79 206 549630 19613 110019850
Hypopnoea 44.33 9.79 141 549695 11239 110028224
Nerve injury 43.82 9.79 135 549701 10578 110028885
Pleural thickening 43.57 9.79 68 549768 3331 110036132
Agranulocytosis 43.44 9.79 159 549677 61601 109977862
Venoocclusive liver disease 43.41 9.79 11 549825 15196 110024267
Right ventricular hypertrophy 43.38 9.79 48 549788 1671 110037792
Disease progression 43.37 9.79 904 548932 243130 109796333
Cognitive disorder 43.28 9.79 643 549193 86868 109952595
Erectile dysfunction 43.21 9.79 195 549641 18361 110021102
Red blood cell sedimentation rate abnormal 43.20 9.79 35 549801 24474 110014989
Somatic symptom disorder 43.03 9.79 65 549771 3094 110036369
Accidental poisoning 42.47 9.79 57 549779 2430 110037033
Product administration interrupted 42.26 9.79 138 549698 11154 110028309
Drug abuser 42.04 9.79 87 549749 5322 110034141
Herpes zoster 41.98 9.79 765 549071 107614 109931849
Child abuse 41.84 9.79 35 549801 854 110038609
Drug screen positive 41.73 9.79 96 549740 6314 110033149
Melaena 41.46 9.79 188 549648 68569 109970894
Limb discomfort 41.43 9.79 346 549490 40508 109998955
Infusion site reaction 41.37 9.79 18 549818 17664 110021799
Tardive dyskinesia 41.34 9.79 155 549681 13424 110026039
Paranoia 41.28 9.79 220 549616 22154 110017309
Central nervous system lesion 41.25 9.79 170 549666 15383 110024080
Haematotoxicity 41.20 9.79 27 549809 21055 110018408
Graft versus host disease 41.14 9.79 21 549815 18785 110020678
Aggression 41.08 9.79 463 549373 58747 109980716
Chronic obstructive pulmonary disease 41.07 9.79 767 549069 108391 109931072
Multiple organ dysfunction syndrome 40.93 9.79 520 549316 151190 109888273
Coordination abnormal 40.53 9.79 239 549597 24989 110014474
Quality of life decreased 40.08 9.79 158 549678 14011 110025452
Proteinuria 40.01 9.79 87 549749 39931 109999532
Underdose 40.00 9.79 171 549665 63383 109976080
Neutrophil count decreased 39.94 9.79 396 549440 120545 109918918
Anorgasmia 39.89 9.79 45 549791 1601 110037862
Victim of child abuse 39.89 9.79 39 549797 1172 110038291
Nerve compression 39.80 9.79 134 549702 11003 110028460
Acute myeloid leukaemia 39.65 9.79 81 549755 38029 110001434
Back injury 39.62 9.79 113 549723 47286 109992177
Panniculitis 39.52 9.79 14 549822 15568 110023895
Somatic delusion 39.46 9.79 31 549805 690 110038773
Injection site mass 39.43 9.79 233 549603 24380 110015083
Epstein-Barr virus infection 39.42 9.79 22 549814 18716 110020747
Epidural lipomatosis 39.39 9.79 50 549786 2017 110037446
Myokymia 39.38 9.79 18 549818 138 110039325
Mental impairment 39.34 9.79 219 549617 22420 110017043
Vaginal discharge 39.17 9.79 20 549816 17888 110021575
Allodynia 39.08 9.79 50 549786 2033 110037430
Intentional self-injury 39.03 9.79 319 549517 37110 110002353
Spinal osteoarthritis 38.99 9.79 201 549635 19982 110019481
Slow speech 38.78 9.79 65 549771 3383 110036080
Foot deformity 38.77 9.79 118 549718 48362 109991101
Cystitis haemorrhagic 38.58 9.79 7 549829 12202 110027261
Myocarditis 38.48 9.79 56 549780 29999 110009464
Deep vein thrombosis 38.43 9.79 939 548897 138948 109900515
Finger deformity 38.25 9.79 66 549770 33026 110006437
Myasthenia gravis 37.98 9.79 209 549627 21302 110018161
Analgesic therapy 37.79 9.79 100 549736 7184 110032279
Gout 37.79 9.79 311 549525 36255 110003208
Blood magnesium increased 37.69 9.79 68 549768 3755 110035708
Thinking abnormal 37.45 9.79 162 549674 14978 110024485
Back disorder 37.43 9.79 204 549632 20718 110018745
Colitis ulcerative 37.43 9.79 228 549608 77135 109962328
Hypermobility syndrome 37.13 9.79 27 549809 533 110038930
Therapeutic response decreased 37.09 9.79 304 549532 96195 109943268
Cardiac failure congestive 36.92 9.79 998 548838 150002 109889461
Metabolic encephalopathy 36.85 9.79 130 549706 10930 110028533
Influenza like illness 36.71 9.79 631 549205 87781 109951682
Premature delivery 36.42 9.79 60 549776 30572 110008891
Hip fracture 36.34 9.79 299 549537 34852 110004611
Pre-existing condition improved 36.33 9.79 92 549744 6434 110033029
Osteonecrosis of jaw 36.20 9.79 120 549716 47897 109991566
Visual snow syndrome 36.16 9.79 13 549823 48 110039415
Adverse event 36.04 9.79 356 549480 108453 109931010
Rib fracture 35.86 9.79 289 549547 33481 110005982
Myocardial stunning 35.79 9.79 22 549814 324 110039139
Incoherent 35.76 9.79 107 549729 8251 110031212
Pollakiuria 35.53 9.79 356 549480 43839 109995624
Depressed mood 35.42 9.79 460 549376 60349 109979114
Female genital tract fistula 35.32 9.79 19 549817 16500 110022963
Pulmonary alveolar haemorrhage 35.24 9.79 29 549807 20121 110019342
Psychomotor hyperactivity 35.13 9.79 196 549640 20081 110019382
Product use issue 34.92 9.79 1233 548603 310462 109729001
Chronic sinusitis 34.88 9.79 44 549792 25040 110014423
Cholangitis 34.62 9.79 19 549817 16316 110023147
Increased appetite 34.58 9.79 157 549679 14820 110024643
Frequent bowel movements 34.22 9.79 211 549625 71179 109968284
Decreased appetite 34.18 9.79 1976 547860 473870 109565593
Hepatic failure 34.09 9.79 201 549635 68538 109970925
Tooth loss 34.03 9.79 103 549733 7993 110031470
Proctitis 34.01 9.79 21 549815 16906 110022557
Road traffic accident 33.67 9.79 356 549480 107042 109932421
Decreased interest 33.62 9.79 75 549761 4833 110034630
Persistent depressive disorder 33.47 9.79 39 549797 1438 110038025
Abnormal dreams 33.35 9.79 139 549697 12641 110026822
Body height decreased 33.35 9.79 122 549714 10441 110029022
Parosmia 33.35 9.79 142 549694 13038 110026425
Rash maculo-papular 33.22 9.79 224 549612 73998 109965465
Pustular psoriasis 33.20 9.79 13 549823 13592 110025871
Ligament sprain 33.13 9.79 163 549673 15905 110023558
Narcolepsy 32.80 9.79 40 549796 1548 110037915
Hypertension 32.65 9.79 2141 547695 507943 109531520
Exposure via ingestion 32.58 9.79 74 549762 4826 110034637
Hot flush 32.57 9.79 485 549351 65551 109973912
Neurologic neglect syndrome 32.44 9.79 4 549832 9294 110030169
Foot fracture 32.42 9.79 228 549608 25318 110014145
Hypokalaemia 32.37 9.79 676 549160 181772 109857691
Sleep disorder therapy 32.30 9.79 96 549740 7375 110032088
Jaundice 32.22 9.79 168 549668 59068 109980395
Vascular malformation 32.16 9.79 29 549807 785 110038678
Blood phosphorus increased 31.75 9.79 163 549673 16177 110023286
Carotid artery thrombosis 31.62 9.79 5 549831 9633 110029830
Substance abuse 31.32 9.79 134 549702 12329 110027134
Concussion 31.30 9.79 127 549709 11411 110028052
Focal dyscognitive seizures 31.21 9.79 63 549773 3786 110035677
Pituitary tumour benign 31.13 9.79 53 549783 2794 110036669
Posterior reversible encephalopathy syndrome 31.13 9.79 77 549759 33784 110005679
Movement disorder 31.10 9.79 297 549539 36107 110003356
Polyarthritis 31.10 9.79 29 549807 18934 110020529
Joint destruction 31.07 9.79 8 549828 10935 110028528
Osteomyelitis 30.97 9.79 298 549538 36302 110003161
Graft versus host disease in gastrointestinal tract 30.95 9.79 4 549832 8964 110030499
Epigastric discomfort 30.93 9.79 107 549729 8908 110030555
Drug therapy 30.87 9.79 93 549743 7198 110032265
Tumour lysis syndrome 30.76 9.79 67 549769 30734 110008729
Arthralgia 30.35 9.79 3403 546433 776229 109263234
Impaired quality of life 30.32 9.79 254 549582 29763 110009700
Acute graft versus host disease in skin 30.21 9.79 8 549828 10732 110028731
Pathogen resistance 30.21 9.79 26 549810 17646 110021817
Pleural effusion 30.20 9.79 663 549173 177046 109862417
Bipolar disorder 30.12 9.79 106 549730 8901 110030562
Gingival pain 29.90 9.79 156 549680 15580 110023883
Breakthrough pain 29.84 9.79 38 549798 1538 110037925
Conversion disorder 29.81 9.79 47 549789 2323 110037140
Oesophageal spasm 29.72 9.79 60 549776 3606 110035857
Joint dislocation 29.70 9.79 80 549756 34110 110005353
Hyperbilirubinaemia 29.58 9.79 68 549768 30603 110008860
Blood parathyroid hormone decreased 29.57 9.79 14 549822 13075 110026388
Distributive shock 29.56 9.79 80 549756 5824 110033639
Paranasal cyst 29.56 9.79 29 549807 875 110038588
Parasomnia 29.54 9.79 27 549809 744 110038719
Pulmonary tuberculosis 29.41 9.79 5 549831 9134 110030329
Blood potassium decreased 29.30 9.79 404 549432 53710 109985753
Skin toxicity 29.19 9.79 11 549825 11772 110027691
Paradoxical drug reaction 29.01 9.79 111 549725 9706 110029757
Eosinophilia 28.95 9.79 169 549667 57767 109981696
Renal impairment 28.69 9.79 715 549121 187730 109851733
Catarrh 28.68 9.79 91 549745 7244 110032219
Blood bilirubin increased 28.44 9.79 241 549595 75731 109963732
Metastases to liver 28.39 9.79 86 549750 35300 110004163
Cyst 28.28 9.79 159 549677 16337 110023126
Snoring 28.23 9.79 86 549750 6698 110032765
Violence-related symptom 28.12 9.79 29 549807 930 110038533
Hypothyroidism 27.86 9.79 230 549606 72669 109966794
Neurogenic bladder 27.65 9.79 71 549765 5008 110034455
Disability 27.57 9.79 69 549767 30154 110009309
Transaminases increased 27.53 9.79 193 549643 63197 109976266
Electrocardiogram QRS complex prolonged 27.50 9.79 133 549703 12888 110026575
Therapy non-responder 27.27 9.79 585 549251 156722 109882741
Uveitis 27.26 9.79 41 549795 21669 110017794
Nephrogenic systemic fibrosis 27.16 9.79 74 549762 5409 110034054
Spinal stenosis 27.13 9.79 175 549661 18881 110020582
Sweat gland disorder 27.10 9.79 16 549820 218 110039245
Cerebral infarction 27.10 9.79 149 549687 51689 109987774
Carpal tunnel syndrome 27.07 9.79 199 549637 22411 110017052
Cardiac failure acute 26.95 9.79 49 549787 24029 110015434
Condition aggravated 26.72 9.79 3222 546614 731614 109307849
Chronic graft versus host disease 26.69 9.79 7 549829 9450 110030013
Autonomic nervous system imbalance 26.65 9.79 76 549760 5704 110033759
Sleep disorder 26.26 9.79 769 549067 197875 109841588
Delusion 26.16 9.79 205 549631 23550 110015913
Analgesic drug level above therapeutic 25.97 9.79 21 549815 488 110038975
Pseudomonas infection 25.87 9.79 63 549773 27790 110011673
Transplant dysfunction 25.84 9.79 5 549831 8323 110031140
Respiratory rate decreased 25.73 9.79 79 549757 6179 110033284
Schizophrenia 25.72 9.79 43 549793 21783 110017680
Lumbar radiculopathy 25.60 9.79 46 549790 2532 110036931
Product quality issue 25.56 9.79 253 549583 77046 109962417
Abdominal pain upper 25.55 9.79 1447 548389 347664 109691799
Drug eruption 25.51 9.79 159 549677 53500 109985963
Macular degeneration 25.22 9.79 43 549793 21616 110017847
Phantom limb syndrome 25.12 9.79 19 549817 399 110039064
Toxic epidermal necrolysis 24.99 9.79 172 549664 56555 109982908
Anaphylactic shock 24.89 9.79 152 549684 51394 109988069
Illness 24.84 9.79 559 549277 81612 109957851
Generalised tonic-clonic seizure 24.82 9.79 396 549440 54284 109985179
Product used for unknown indication 24.79 9.79 39 549797 1924 110037539
Sensory disturbance 24.78 9.79 160 549676 17269 110022194
Rib deformity 24.63 9.79 15 549821 217 110039246
Enterocolitis 24.56 9.79 35 549801 18914 110020549
Diffuse axonal injury 24.52 9.79 12 549824 109 110039354
Neutropenic sepsis 24.47 9.79 75 549761 30671 110008792
Drug interaction 24.35 9.79 2842 546994 497341 109542122
Bronchial wall thickening 24.24 9.79 51 549785 3156 110036307
Musculoskeletal chest pain 23.98 9.79 234 549602 28613 110010850
Somnambulism 23.72 9.79 78 549758 6327 110033136
Peroneal nerve palsy 23.72 9.79 86 549750 7328 110032135
Alcohol interaction 23.69 9.79 55 549781 3639 110035824
Arteriovenous malformation 23.59 9.79 38 549798 1913 110037550
Oesophageal obstruction 23.58 9.79 30 549806 1213 110038250
Angioedema 23.54 9.79 346 549490 98154 109941309
Anal incontinence 23.34 9.79 188 549648 21776 110017687
Hypokinesia 23.29 9.79 187 549649 21639 110017824
Jaundice cholestatic 23.18 9.79 23 549813 14585 110024878
Akathisia 23.06 9.79 155 549681 16958 110022505
Acute hepatic failure 23.03 9.79 98 549738 36370 110003093
Myoclonic epilepsy 22.96 9.79 45 549791 2646 110036817
Formication 22.94 9.79 71 549765 5577 110033886
Granuloma skin 22.67 9.79 14 549822 11269 110028194
Pneumonitis 22.67 9.79 257 549579 76274 109963189
Hypoacusis 22.55 9.79 271 549565 34920 110004543
Dependence 22.52 9.79 45 549791 2684 110036779
Hyperlipidaemia 22.50 9.79 275 549561 35573 110003890
Affective disorder 22.45 9.79 113 549723 11128 110028335
Cytomegalovirus colitis 22.42 9.79 4 549832 7057 110032406
Antidepressant drug level above therapeutic 22.40 9.79 23 549813 734 110038729
Drug ineffective 22.39 9.79 8145 541691 1512395 108527068
Monoparesis 22.11 9.79 61 549775 4492 110034971
Mechanical ventilation complication 22.04 9.79 23 549813 748 110038715
Binocular eye movement disorder 22.01 9.79 12 549824 139 110039324
Complications of transplanted kidney 21.99 9.79 5 549831 7437 110032026
Hypomagnesaemia 21.93 9.79 193 549643 60177 109979286
Accident 21.80 9.79 110 549726 10842 110028621
Respiratory tract infection 21.80 9.79 239 549597 71378 109968085
Nocturia 21.77 9.79 152 549684 16838 110022625
Nephrotic syndrome 21.70 9.79 22 549814 13809 110025654
Decreased immune responsiveness 21.66 9.79 100 549736 9506 110029957
Graft versus host disease in skin 21.66 9.79 7 549829 8247 110031216
Localised infection 21.55 9.79 317 549519 42731 109996732
Flushing 21.42 9.79 677 549159 104059 109935404
Spinal disorder 21.42 9.79 115 549721 11613 110027850
Major depression 21.37 9.79 107 549729 10514 110028949
Steroid dependence 21.24 9.79 91 549745 8378 110031085
Atrial fibrillation 21.22 9.79 929 548907 228713 109810750
Haemolysis 21.16 9.79 28 549808 15611 110023852
Drug tolerance increased 21.12 9.79 20 549816 577 110038886
Dry eye 20.97 9.79 392 549444 55401 109984062
Dysphoria 20.94 9.79 75 549761 6353 110033110
Leukopenia 20.94 9.79 571 549265 148220 109891243
Psychotic disorder due to a general medical condition 20.85 9.79 15 549821 291 110039172
Organising pneumonia 20.85 9.79 24 549812 14219 110025244
Delirium tremens 20.75 9.79 22 549814 729 110038734
Facial pain 20.71 9.79 139 549697 15200 110024263
Nasal polyps 20.70 9.79 21 549815 13179 110026284
Nitrite urine present 20.63 9.79 28 549808 1207 110038256
Long QT syndrome 20.61 9.79 5 549831 7113 110032350
Shock haemorrhagic 20.61 9.79 68 549768 27179 110012284
Congenital multiplex arthrogryposis 20.56 9.79 7 549829 21 110039442
Syncope 20.56 9.79 1217 548619 201319 109838144
Pulmonary function test abnormal 20.44 9.79 63 549773 4937 110034526
Obstruction 20.37 9.79 69 549767 5683 110033780
Injection site induration 20.37 9.79 111 549725 11272 110028191
Impaired work ability 20.37 9.79 211 549625 26208 110013255
Peritonitis 20.36 9.79 88 549748 32519 110006944
Immunosuppressant drug level increased 20.34 9.79 17 549819 11707 110027756
Alanine aminotransferase increased 20.33 9.79 728 549108 183045 109856418
Cervical spinal stenosis 20.20 9.79 45 549791 2897 110036566
Product physical issue 20.17 9.79 63 549773 4973 110034490
Acute coronary syndrome 20.13 9.79 54 549782 23058 110016405
Pruritus 20.11 9.79 2558 547278 579002 109460461
Tuberculosis 20.04 9.79 36 549800 17738 110021725
Autoimmune haemolytic anaemia 20.02 9.79 14 549822 10553 110028910
Feeling of body temperature change 19.99 9.79 72 549764 6116 110033347
Brain injury 19.96 9.79 125 549711 13351 110026112
Post herpetic neuralgia 19.93 9.79 48 549788 3253 110036210
Disorganised speech 19.91 9.79 48 549788 3255 110036208
Alcohol withdrawal syndrome 19.88 9.79 37 549799 2093 110037370
Drug screen false positive 19.84 9.79 29 549807 1340 110038123
Rectal haemorrhage 19.80 9.79 449 549387 119384 109920079
Intrusive thoughts 19.71 9.79 21 549815 700 110038763
Skin necrosis 19.71 9.79 49 549787 21463 110018000
Secondary progressive multiple sclerosis 19.57 9.79 31 549805 1538 110037925
Blood potassium increased 19.56 9.79 252 549584 32997 110006466
Facial spasm 19.50 9.79 23 549813 859 110038604
Acute respiratory failure 19.42 9.79 501 549335 74759 109964704
Weight increased 19.39 9.79 1809 548027 417835 109621628
Varicella zoster virus infection 19.39 9.79 4 549832 6364 110033099
Stenotrophomonas infection 19.31 9.79 3 549833 5855 110033608
Post procedural complication 19.19 9.79 210 549626 26448 110013015
Eosinophilic granulomatosis with polyangiitis 19.16 9.79 15 549821 10671 110028792
Hypoxic-ischaemic encephalopathy 19.14 9.79 91 549745 8756 110030707
Mastoiditis 19.13 9.79 41 549795 2570 110036893
Bone pain 19.03 9.79 441 549395 64692 109974771
Duodenal ulcer 19.03 9.79 43 549793 19471 110019992
Post-traumatic stress disorder 19.02 9.79 74 549762 6522 110032941
Adenovirus infection 19.01 9.79 16 549820 10978 110028485
Creatinine renal clearance decreased 18.98 9.79 51 549785 21764 110017699
Alcohol poisoning 18.96 9.79 92 549744 8928 110030535
Therapeutic product effect incomplete 18.95 9.79 914 548922 222891 109816572
Band sensation 18.86 9.79 25 549811 1053 110038410
Ear infection 18.84 9.79 210 549626 62522 109976941
Stevens-Johnson syndrome 18.83 9.79 146 549690 46755 109992708
Drug screen negative 18.79 9.79 15 549821 342 110039121
Pulmonary embolism 18.71 9.79 1272 548564 213202 109826261
Hyperuricaemia 18.67 9.79 27 549809 14504 110024959
Aphasia 18.67 9.79 404 549432 58593 109980870
Immune-mediated enterocolitis 18.64 9.79 14 549822 10171 110029292
Emotional distress 18.59 9.79 320 549516 44527 109994936
Bronchitis 18.58 9.79 957 548879 156075 109883388
Osteosclerosis 18.57 9.79 57 549779 4458 110035005
Pre-eclampsia 18.42 9.79 10 549826 8640 110030823
Cerebral disorder 18.41 9.79 75 549761 6751 110032712
Dysgeusia 18.39 9.79 467 549369 69518 109969945
Obstructive airways disorder 18.37 9.79 144 549692 46005 109993458
Cystitis 18.35 9.79 444 549392 65592 109973871
Gastrointestinal toxicity 18.34 9.79 17 549819 11131 110028332
Communication disorder 18.34 9.79 61 549775 4978 110034485
Adjustment disorder 18.31 9.79 16 549820 10779 110028684
Toxic encephalopathy 18.27 9.79 134 549702 15080 110024383
Palmar-plantar erythrodysaesthesia syndrome 18.26 9.79 124 549712 40901 109998562
Ischaemic stroke 18.23 9.79 125 549711 41138 109998325
Opisthotonus 18.22 9.79 21 549815 765 110038698
Autonomic dysreflexia 18.20 9.79 17 549819 482 110038981
Micrognathia 18.14 9.79 6 549830 16 110039447
Gestational diabetes 18.13 9.79 7 549829 7382 110032081
Endophthalmitis 18.12 9.79 9 549827 8178 110031285
Gamma-glutamyltransferase increased 18.11 9.79 206 549630 61103 109978360
Ear deformity acquired 18.10 9.79 5 549831 5 110039458
Deafness neurosensory 18.03 9.79 95 549741 9524 110029939
Unintentional medical device removal 18.03 9.79 11 549825 8912 110030551
Skin reaction 17.97 9.79 50 549786 21094 110018369
Device difficult to use 17.89 9.79 42 549794 18763 110020700
Sacroiliitis 17.88 9.79 60 549776 4918 110034545
Osteoporosis 17.88 9.79 315 549521 86837 109952626
Gastric cancer 17.86 9.79 17 549819 10991 110028472
Cerebral haemorrhage 17.77 9.79 222 549614 64746 109974717
Dermatitis exfoliative generalised 17.73 9.79 17 549819 10955 110028508
Sternal fracture 17.69 9.79 46 549790 3270 110036193
Clonus 17.67 9.79 88 549748 8628 110030835
Monoclonal immunoglobulin present 17.61 9.79 39 549797 2501 110036962
Lumbar spinal stenosis 17.60 9.79 71 549765 6362 110033101
Myocardial infarction 17.43 9.79 1143 548693 190940 109848523
Hospice care 17.42 9.79 114 549722 12359 110027104
Dental caries 17.39 9.79 116 549720 12657 110026806
Gastrointestinal motility disorder 17.35 9.79 77 549759 7199 110032264
Gait apraxia 17.33 9.79 7 549829 38 110039425
Developmental hip dysplasia 17.31 9.79 13 549823 270 110039193
Idiopathic neutropenia 17.24 9.79 4 549832 0 110039463
Kidney infection 17.22 9.79 199 549637 25400 110014063
Anion gap abnormal 17.17 9.79 21 549815 815 110038648
Spinal fracture 17.09 9.79 180 549656 22453 110017010
Administration site bruise 17.07 9.79 12 549824 224 110039239
Hepatocellular injury 17.06 9.79 165 549671 50477 109988986
Hyperthyroidism 17.05 9.79 81 549755 29180 110010283
Therapy interrupted 17.01 9.79 345 549491 49477 109989986
Medication overuse headache 16.96 9.79 29 549807 1534 110037929
Osteopenia 16.94 9.79 177 549659 22032 110017431
Application site pain 16.93 9.79 63 549773 5436 110034027
Iron deficiency 16.92 9.79 153 549683 18323 110021140
Nystagmus 16.90 9.79 107 549729 11470 110027993
Breast pain 16.89 9.79 96 549740 9904 110029559
Skin discolouration 16.87 9.79 340 549496 48706 109990757
Drug diversion 16.85 9.79 27 549809 1353 110038110
Substance use 16.83 9.79 38 549798 2468 110036995
Opiates positive 16.77 9.79 22 549814 917 110038546
Kidney transplant rejection 16.69 9.79 21 549815 11966 110027497
Overweight 16.63 9.79 70 549766 6394 110033069
Post laminectomy syndrome 16.60 9.79 15 549821 407 110039056
Inflammatory marker increased 16.59 9.79 29 549807 14440 110025023
Breast cancer stage I 16.54 9.79 8 549828 7379 110032084
Arthrofibrosis 16.53 9.79 9 549827 104 110039359
Essential hypertension 16.46 9.79 80 549756 7767 110031696
Thoracic outlet syndrome 16.46 9.79 10 549826 144 110039319
Forced expiratory volume decreased 16.43 9.79 25 549811 13151 110026312
Incontinence 16.40 9.79 140 549696 16495 110022968
Hypervolaemia 16.40 9.79 341 549495 49119 109990344
Head banging 16.34 9.79 17 549819 551 110038912
Allergic reaction to excipient 16.30 9.79 20 549816 779 110038684
Premature labour 16.29 9.79 13 549823 9159 110030304
Polyneuropathy in malignant disease 16.25 9.79 16 549820 485 110038978
Acute graft versus host disease in intestine 16.25 9.79 4 549832 5635 110033828
Oesophageal carcinoma 16.25 9.79 20 549816 11504 110027959
Sports injury 16.24 9.79 11 549825 193 110039270
JC polyomavirus test positive 16.23 9.79 36 549800 2311 110037152
Myofascial pain syndrome 16.16 9.79 38 549798 2535 110036928
Prostate cancer 16.15 9.79 115 549721 37526 110001937
Sneezing 16.14 9.79 93 549743 31891 110007572
Chest X-ray abnormal 16.03 9.79 84 549752 8403 110031060
Acute respiratory distress syndrome 16.01 9.79 178 549658 53020 109986443
Brain death 16.00 9.79 70 549766 6503 110032960
Labelled drug-drug interaction medication error 15.99 9.79 83 549753 29219 110010244
Ulcer haemorrhage 15.94 9.79 58 549778 22513 110016950
Cardiac murmur 15.93 9.79 190 549646 24438 110015025
Migraine 15.86 9.79 1023 548813 170629 109868834
Abnormal sleep-related event 15.83 9.79 21 549815 885 110038578
Bipolar I disorder 15.76 9.79 35 549801 2248 110037215
Post procedural infection 15.66 9.79 120 549716 13689 110025774
Sleep paralysis 15.62 9.79 21 549815 897 110038566
Abortion spontaneous 15.57 9.79 103 549733 34179 110005284
Toxic skin eruption 15.55 9.79 77 549759 27438 110012025
Cytomegalovirus chorioretinitis 15.53 9.79 8 549828 7120 110032343
Haematuria 15.47 9.79 305 549531 82700 109956763
Mucormycosis 15.46 9.79 18 549818 10610 110028853
Blood pressure systolic increased 15.46 9.79 305 549531 82686 109956777
Diffuse large B-cell lymphoma recurrent 15.40 9.79 6 549830 6293 110033170
Antacid therapy 15.39 9.79 61 549775 5423 110034040
Hepatitis fulminant 15.37 9.79 12 549824 8548 110030915
Neurosis 15.34 9.79 17 549819 593 110038870
Contusion 15.33 9.79 977 548859 232384 109807079
Rales 15.30 9.79 67 549769 24672 110014791
Bone cyst 15.30 9.79 46 549790 3557 110035906
Palpitations 15.28 9.79 952 548884 158260 109881203
Hypoventilation 15.28 9.79 80 549756 8001 110031462
Nervous system disorder 15.26 9.79 232 549604 31489 110007974
Sepsis 15.25 9.79 1855 547981 325491 109713972
Rapid eye movements sleep abnormal 15.24 9.79 12 549824 268 110039195
Neck surgery 15.24 9.79 33 549803 2084 110037379
Face injury 15.14 9.79 53 549783 4439 110035024
Needle track marks 15.11 9.79 8 549828 87 110039376
Blood glucose decreased 15.10 9.79 218 549618 29270 110010193
Ventricular fibrillation 15.09 9.79 289 549547 41024 109998439
Paraesthesia 15.06 9.79 1583 548253 274938 109764525
Neurotoxicity 14.99 9.79 294 549542 41913 109997550
Chronic idiopathic pain syndrome 14.96 9.79 11 549825 221 110039242
Exostosis 14.95 9.79 151 549685 45805 109993658
Myelodysplastic syndrome 14.90 9.79 117 549719 37367 110002096
Thyroiditis 14.90 9.79 7 549829 6566 110032897
Emotional disorder 14.89 9.79 134 549702 16026 110023437
Colorectal cancer 14.87 9.79 14 549822 9100 110030363
Impaired gastric emptying 14.86 9.79 115 549721 13160 110026303
Miosis 14.84 9.79 171 549665 21812 110017651
Immune-mediated lung disease 14.82 9.79 4 549832 5299 110034164
Upper limb fracture 14.79 9.79 164 549672 20724 110018739
Dermatitis atopic 14.78 9.79 193 549643 25348 110014115
Hyperacusis 14.78 9.79 40 549796 2912 110036551
Bradykinesia 14.71 9.79 98 549738 10690 110028773
Gait inability 14.68 9.79 542 549294 135834 109903629
Hallucination, auditory 14.67 9.79 198 549638 26199 110013264
Sleep disorder due to a general medical condition 14.66 9.79 177 549659 51935 109987528
Eosinophilic colitis 14.61 9.79 17 549819 626 110038837
Brief psychotic disorder with marked stressors 14.57 9.79 13 549823 347 110039116
Cardiac disorder 14.55 9.79 489 549347 75791 109963672
Confusional arousal 14.54 9.79 10 549826 180 110039283
Anticoagulant therapy 14.54 9.79 59 549777 5302 110034161
Panic disorder 14.52 9.79 44 549792 3417 110036046
Product substitution issue 14.52 9.79 177 549659 22884 110016579
Eyelid myoclonus 14.50 9.79 9 549827 135 110039328
Bladder disorder 14.48 9.79 100 549736 11037 110028426
Swollen tongue 14.48 9.79 398 549438 59964 109979499
Congenital neuropathy 14.45 9.79 5 549831 16 110039447
Personality change 14.43 9.79 99 549737 10903 110028560
Fibula fracture 14.43 9.79 53 549783 4545 110034918
Intervertebral disc disorder 14.42 9.79 60 549776 5452 110034011
Amphetamines positive 14.41 9.79 12 549824 291 110039172
Urine amphetamine positive 14.38 9.79 9 549827 137 110039326
Breast disorder 14.35 9.79 34 549802 2280 110037183
Product use in unapproved indication 14.33 9.79 2481 547355 444896 109594567
Muscular weakness 14.33 9.79 1428 548408 247040 109792423
Product adhesion issue 14.33 9.79 40 549796 2966 110036497
Libido decreased 14.29 9.79 63 549773 5872 110033591
Dysphagia 14.29 9.79 916 548920 152684 109886779
Vertebral foraminal stenosis 14.28 9.79 25 549811 1348 110038115
Peripheral vascular disorder 14.26 9.79 82 549754 8494 110030969
Ageusia 14.26 9.79 155 549681 19490 110019973
Intentional underdose 14.23 9.79 36 549800 2516 110036947
Substance-induced psychotic disorder 14.16 9.79 59 549777 5365 110034098
Carotid artery disease 14.15 9.79 33 549803 2190 110037273
Self-medication 14.14 9.79 65 549771 6167 110033296
Hypocalcaemia 14.14 9.79 234 549602 65132 109974331
Sleep deficit 14.14 9.79 29 549807 1763 110037700
Acute myeloid leukaemia recurrent 14.13 9.79 4 549832 5135 110034328
Pseudostroke 14.12 9.79 10 549826 189 110039274
Middle ear inflammation 14.11 9.79 11 549825 242 110039221
Morbid thoughts 14.10 9.79 20 549816 899 110038564
CD8 lymphocytes decreased 14.07 9.79 12 549824 301 110039162
Immune system disorder 14.04 9.79 115 549721 13386 110026077
Choreoathetosis 14.01 9.79 28 549808 1670 110037793
Fungating wound 13.99 9.79 7 549829 67 110039396
Dehydration 13.96 9.79 1591 548245 277920 109761543
Enterococcal infection 13.95 9.79 53 549783 20313 110019150
Tachyphrenia 13.95 9.79 34 549802 2322 110037141
Gun shot wound 13.91 9.79 22 549814 1090 110038373
Toxicologic test abnormal 13.86 9.79 24 549812 1283 110038180
Rotator cuff syndrome 13.85 9.79 136 549700 16658 110022805
Amnesia 13.84 9.79 649 549187 104759 109934704
Cardiac failure chronic 13.83 9.79 30 549806 13781 110025682
Bedridden 13.77 9.79 114 549722 13311 110026152
Hysterectomy 13.77 9.79 78 549758 8036 110031427
Postmortem blood drug level increased 13.76 9.79 23 549813 1194 110038269
Neuromyelitis optica spectrum disorder 13.74 9.79 26 549810 1489 110037974
Mitral valve prolapse 13.74 9.79 34 549802 2344 110037119
Hallucinations, mixed 13.74 9.79 82 549754 8611 110030852
Stress cardiomyopathy 13.72 9.79 37 549799 15769 110023694
Pneumomediastinum 13.70 9.79 4 549832 5032 110034431
Musculoskeletal discomfort 13.68 9.79 178 549658 23360 110016103
Progressive multiple sclerosis 13.63 9.79 24 549812 1300 110038163
Product selection error 13.63 9.79 14 549822 447 110039016
Cardiotoxicity 13.56 9.79 41 549795 16840 110022623
Oropharyngeal oedema 13.53 9.79 14 549822 451 110039012
Diabetes mellitus 13.51 9.79 614 549222 98767 109940696
Haemolytic uraemic syndrome 13.49 9.79 4 549832 4981 110034482
Mitochondrial encephalomyopathy 13.49 9.79 8 549828 110 110039353
Abortion induced 13.46 9.79 12 549824 8007 110031456
Human herpesvirus 6 infection 13.45 9.79 8 549828 6573 110032890
Mite allergy 13.43 9.79 6 549830 5797 110033666
Asthenia 13.40 9.79 3732 546104 685267 109354196
Teeth brittle 13.39 9.79 16 549820 606 110038857
Alanine aminotransferase abnormal 13.37 9.79 16 549820 9318 110030145
Systemic candida 13.35 9.79 18 549818 9956 110029507
Chronic inflammatory demyelinating polyradiculoneuropathy 13.34 9.79 32 549804 2163 110037300
Asphyxia 13.32 9.79 32 549804 14183 110025280
Benign prostatic hyperplasia 13.29 9.79 144 549692 18090 110021373
Malaise 13.25 9.79 3048 546788 668771 109370692
Increased tendency to bruise 13.24 9.79 102 549734 11656 110027807
Blood pressure systolic abnormal 13.22 9.79 71 549765 24779 110014684
Pneumonia fungal 13.21 9.79 34 549802 14720 110024743
Diabetic foot infection 13.21 9.79 19 549817 865 110038598
Priapism 13.21 9.79 61 549775 5800 110033663
Product taste abnormal 13.20 9.79 35 549801 2517 110036946
Application site vesicles 13.16 9.79 26 549810 1538 110037925
Femoral artery dissection 13.13 9.79 6 549830 46 110039417
Scar 13.10 9.79 135 549701 16746 110022717
Naevus haemorrhage 13.06 9.79 8 549828 117 110039346
Drug withdrawal syndrome neonatal 13.06 9.79 12 549824 333 110039130
Nasal oedema 13.04 9.79 9 549827 6830 110032633
Muscle spasticity 13.04 9.79 251 549585 35664 110003799
Regressive behaviour 13.02 9.79 10 549826 215 110039248
JC virus infection 13.00 9.79 5 549831 5285 110034178
Electroencephalogram abnormal 13.00 9.79 63 549773 6110 110033353
Gingival atrophy 13.00 9.79 7 549829 79 110039384
Feeling of despair 12.96 9.79 45 549791 3753 110035710
Immunodeficiency 12.95 9.79 268 549568 38570 110000893
Tinel's sign 12.93 9.79 3 549833 0 110039463
CSF neutrophil count increased 12.93 9.79 3 549833 0 110039463
Ligamentitis 12.93 9.79 3 549833 0 110039463
Hypercalcaemia 12.92 9.79 159 549677 46498 109992965
Subileus 12.91 9.79 8 549828 6429 110033034
Progressive relapsing multiple sclerosis 12.91 9.79 6 549830 48 110039415
Pneumonia bacterial 12.91 9.79 77 549759 26184 110013279
Prophylaxis 12.88 9.79 4 549832 8 110039455
Magnetic resonance imaging abnormal 12.83 9.79 46 549790 3899 110035564
Oesophageal pain 12.80 9.79 55 549781 5070 110034393
Sleep attacks 12.79 9.79 10 549826 221 110039242
Hypophosphataemia 12.77 9.79 234 549602 32948 110006515
Bone contusion 12.74 9.79 24 549812 1370 110038093
Hemiplegia 12.74 9.79 64 549772 22718 110016745
Self-injurious ideation 12.73 9.79 49 549787 4297 110035166
Dust allergy 12.69 9.79 7 549829 5994 110033469
Hypoalbuminaemia 12.69 9.79 88 549748 28886 110010577
Metastases to peritoneum 12.67 9.79 6 549830 5604 110033859
Hypoaesthesia 12.66 9.79 1765 548071 312458 109727005
Poor quality sleep 12.61 9.79 203 549633 27874 110011589
Device use error 12.58 9.79 16 549820 9073 110030390
Glaucoma 12.55 9.79 169 549667 22348 110017115
Intestinal pseudo-obstruction 12.55 9.79 41 549795 3315 110036148
Paraesthesia oral 12.52 9.79 107 549729 33564 110005899
Product dose omission in error 12.51 9.79 175 549661 23337 110016126
Diffuse large B-cell lymphoma 12.49 9.79 39 549797 15859 110023604
Haematochezia 12.46 9.79 459 549377 115065 109924398
Cytomegalovirus test positive 12.46 9.79 10 549826 7026 110032437
Neutropenic colitis 12.46 9.79 13 549823 8052 110031411
Pseudomonal sepsis 12.44 9.79 16 549820 9030 110030433
Second primary malignancy 12.39 9.79 47 549789 18021 110021442
Schizoaffective disorder 12.35 9.79 39 549797 3097 110036366
CD4 lymphocytes abnormal 12.34 9.79 7 549829 88 110039375
Scoliosis 12.31 9.79 80 549756 8653 110030810
Rocky mountain spotted fever 12.31 9.79 6 549830 54 110039409
Skin cancer 12.30 9.79 139 549697 17645 110021818
Skin laceration 12.29 9.79 236 549600 33517 110005946
Gastrointestinal haemorrhage 12.28 9.79 685 549151 164833 109874630
Paralysis 12.22 9.79 125 549711 15475 110023988
Secondary immunodeficiency 12.21 9.79 4 549832 4672 110034791
Hypometabolism 12.19 9.79 9 549827 182 110039281
Pulse absent 12.19 9.79 97 549739 11195 110028268
Muscular dystrophy 12.16 9.79 10 549826 238 110039225
Epidermal necrosis 12.07 9.79 38 549798 3012 110036451
Tenosynovitis 12.06 9.79 41 549795 16242 110023221
Metabolic surgery 12.06 9.79 24 549812 1427 110038036
Spinal cord injury 12.04 9.79 26 549810 1639 110037824
Deprescribing error 12.03 9.79 6 549830 57 110039406
Laryngectomy 11.96 9.79 5 549831 30 110039433
Vulvar basal cell carcinoma 11.96 9.79 5 549831 30 110039433
Unemployment 11.94 9.79 6 549830 58 110039405
Scleritis 11.94 9.79 6 549830 5414 110034049
Decubitus ulcer 11.93 9.79 141 549695 18095 110021368
Injection site abscess 11.93 9.79 29 549807 1977 110037486
Bladder cancer 11.93 9.79 56 549780 20236 110019227
Oesophageal disorder 11.92 9.79 38 549798 3032 110036431
Leg amputation 11.90 9.79 47 549789 4171 110035292
Light chain analysis increased 11.88 9.79 32 549804 2323 110037140
Lymphoproliferative disorder 11.88 9.79 11 549825 7207 110032256
Carbuncle 11.88 9.79 24 549812 1443 110038020
Retinal haemorrhage 11.87 9.79 18 549818 9483 110029980
Nerve block 11.85 9.79 17 549819 772 110038691
Bronchial secretion retention 11.85 9.79 53 549783 4971 110034492
Drug dose omission by device 11.84 9.79 35 549801 14481 110024982
Musculoskeletal disorder 11.78 9.79 168 549668 22496 110016967
Abnormal weight gain 11.78 9.79 42 549794 3549 110035914
Malignant catatonia 11.78 9.79 16 549820 690 110038773
Product odour abnormal 11.77 9.79 25 549811 1558 110037905
Urine odour abnormal 11.75 9.79 70 549766 7345 110032118
Hypertriglyceridaemia 11.75 9.79 41 549795 16113 110023350
Peripheral swelling 11.73 9.79 1796 548040 402238 109637225
Circulatory collapse 11.72 9.79 147 549689 42846 109996617
Sciatic nerve injury 11.72 9.79 17 549819 780 110038683
Ejaculation delayed 11.70 9.79 9 549827 194 110039269
Protein C deficiency 11.70 9.79 5 549831 32 110039431
Retinal deposits 11.68 9.79 8 549828 143 110039320
Virologic failure 11.65 9.79 5 549831 4947 110034516
Hypoxia 11.62 9.79 770 549066 128745 109910718
Optic neuritis 11.62 9.79 95 549741 11052 110028411
Product communication issue 11.60 9.79 33 549803 2473 110036990
Oral discomfort 11.58 9.79 96 549740 11215 110028248
Suicidal behaviour 11.56 9.79 41 549795 3456 110036007
Nodule 11.56 9.79 105 549731 32526 110006937
Homicidal ideation 11.54 9.79 42 549794 3585 110035878
Basal cell carcinoma 11.53 9.79 157 549679 45113 109994350
Anosognosia 11.53 9.79 3 549833 4071 110035392
Wrist fracture 11.52 9.79 116 549720 14301 110025162
Delusion of parasitosis 11.52 9.79 10 549826 257 110039206
Arthropod bite 11.51 9.79 85 549751 9586 110029877
Left ventricular dysfunction 11.49 9.79 69 549767 23424 110016039
Limb operation 11.48 9.79 45 549791 3979 110035484
Atrioventricular block complete 11.46 9.79 56 549780 20026 110019437
Hyporeflexia 11.45 9.79 46 549790 4114 110035349
Type I hypersensitivity 11.43 9.79 9 549827 6384 110033079
Mood swings 11.43 9.79 168 549668 22644 110016819
Ligament rupture 11.42 9.79 45 549791 3990 110035473
Dizziness postural 11.41 9.79 117 549719 14492 110024971
Erythema multiforme 11.38 9.79 60 549776 21037 110018426
Faecal calprotectin increased 11.35 9.79 10 549826 6709 110032754
Muscle contractions involuntary 11.34 9.79 48 549788 4396 110035067
Hypogonadism male 11.32 9.79 9 549827 204 110039259
Cardiogenic shock 11.30 9.79 369 549467 56969 109982494
Rhinitis 11.28 9.79 166 549670 22379 110017084
Venoocclusive disease 11.28 9.79 9 549827 6341 110033122
Hallucination, tactile 11.24 9.79 19 549817 996 110038467
Presbyopia 11.21 9.79 16 549820 723 110038740
Application site burn 11.21 9.79 19 549817 998 110038465
Essential tremor 11.20 9.79 27 549809 1831 110037632
Medical induction of coma 11.17 9.79 8 549828 154 110039309
Myotonia 11.17 9.79 10 549826 268 110039195
Bacteraemia 11.17 9.79 146 549690 42244 109997219
Inability to afford medication 11.17 9.79 45 549791 4031 110035432
Viral mutation identified 11.16 9.79 4 549832 4415 110035048
Blood calcium increased 11.15 9.79 138 549698 17902 110021561
Blood glucose fluctuation 11.15 9.79 71 549765 7627 110031836
Open angle glaucoma 11.12 9.79 14 549822 560 110038903
Ear disorder 11.10 9.79 51 549785 4838 110034625
Tendon injury 11.10 9.79 32 549804 2417 110037046
Pneumocystis jirovecii infection 11.08 9.79 4 549832 4396 110035067
Otosalpingitis 11.08 9.79 4 549832 15 110039448
Free androgen index decreased 11.08 9.79 4 549832 15 110039448
Turbinectomy 11.08 9.79 4 549832 15 110039448
Infective pulmonary exacerbation of cystic fibrosis 11.08 9.79 37 549799 14734 110024729
Encephalitis 11.07 9.79 52 549784 18787 110020676
Ejection fraction decreased 11.06 9.79 140 549696 40740 109998723
Hyperlactacidaemia 11.04 9.79 15 549821 8271 110031192
Infected skin ulcer 11.03 9.79 44 549792 3923 110035540
Orgasm abnormal 11.03 9.79 9 549827 212 110039251
Conjunctivitis 11.00 9.79 111 549725 33681 110005782
Irregular sleep phase 11.00 9.79 8 549828 158 110039305
Atonic urinary bladder 11.00 9.79 8 549828 158 110039305
Psychiatric symptom 10.98 9.79 81 549755 9132 110030331
Hypertransaminasaemia 10.95 9.79 73 549763 24182 110015281
Knee operation 10.94 9.79 66 549770 6956 110032507
Large intestine perforation 10.93 9.79 44 549792 16585 110022878
Transient ischaemic attack 10.92 9.79 405 549431 63577 109975886
Hepatitis acute 10.91 9.79 52 549784 18714 110020749
Cholestasis 10.87 9.79 241 549595 64277 109975186
Muscle relaxant drug level above therapeutic 10.86 9.79 3 549833 3 110039460
Term birth 10.86 9.79 3 549833 3 110039460
Gastrointestinal inflammation 10.84 9.79 19 549817 9450 110030013
Implant site inflammation 10.84 9.79 10 549826 279 110039184
Pregnancy with contraceptive device 10.82 9.79 3 549833 3904 110035559
Joint stiffness 10.81 9.79 253 549583 66990 109972473
Aortic valve stenosis 10.75 9.79 61 549775 6289 110033174
Burning mouth syndrome 10.71 9.79 15 549821 666 110038797
Gastric bypass 10.69 9.79 23 549813 1446 110038017
Pruritus allergic 10.68 9.79 25 549811 1663 110037800
Blood ethanol 10.68 9.79 7 549829 116 110039347
Erythema 10.67 9.79 1277 548559 290170 109749293
Cerebrospinal fluid leakage 10.65 9.79 29 549807 2119 110037344
Acute myocardial infarction 10.65 9.79 326 549510 83451 109956012
Skin lesion 10.62 9.79 334 549502 51297 109988166
Benign bone neoplasm 10.62 9.79 7 549829 117 110039346
Wrong patient received product 10.57 9.79 63 549773 6611 110032852
Blood thyroid stimulating hormone normal 10.57 9.79 7 549829 118 110039345
Clumsiness 10.57 9.79 42 549794 3738 110035725
Gastrooesophageal reflux disease 10.56 9.79 761 549075 179215 109860248
Confabulation 10.56 9.79 13 549823 508 110038955
Disturbance in social behaviour 10.55 9.79 6 549830 5052 110034411
Dermatitis bullous 10.52 9.79 48 549788 17481 110021982
Stress urinary incontinence 10.50 9.79 27 549809 1906 110037557
Malignant polyp 10.50 9.79 8 549828 170 110039293
Pancreatitis chronic 10.45 9.79 47 549789 4418 110035045
Cryoglobulinaemia 10.45 9.79 21 549815 1258 110038205
Hyperphosphataemia 10.43 9.79 126 549710 16255 110023208
Delirium 10.43 9.79 793 549043 134232 109905231
Maternal exposure during breast feeding 10.43 9.79 4 549832 4234 110035229
Manipulation 10.41 9.79 6 549830 78 110039385
Benign neoplasm of spinal cord 10.41 9.79 3 549833 4 110039459
Camptodactyly congenital 10.41 9.79 3 549833 4 110039459
White blood cell count increased 10.40 9.79 385 549451 96457 109943006
Metastases to lymph nodes 10.37 9.79 39 549797 14993 110024470
Spinal nerve stimulator implantation 10.37 9.79 7 549829 122 110039341
Renal tubular disorder 10.36 9.79 13 549823 7416 110032047
Coronary artery disease 10.20 9.79 445 549391 71245 109968218
Pharyngeal swelling 10.20 9.79 98 549738 11934 110027529
Retching 10.19 9.79 164 549672 22518 110016945
Wrong product administered 10.16 9.79 91 549745 10869 110028594
Post procedural drainage 10.13 9.79 7 549829 127 110039336
Vascular stent thrombosis 10.12 9.79 4 549832 4157 110035306
Systemic infection 10.10 9.79 21 549815 9798 110029665
Caesarean section 10.10 9.79 35 549801 13782 110025681
Myoclonic dystonia 10.09 9.79 6 549830 83 110039380
Administration site swelling 10.08 9.79 14 549822 617 110038846
Antipsychotic drug level increased 10.08 9.79 12 549824 7003 110032460
Hip surgery 10.07 9.79 44 549792 4086 110035377
Obliterative bronchiolitis 10.05 9.79 3 549833 3720 110035743
Anion gap 10.04 9.79 27 549809 1958 110037505
CYP2D6 polymorphism 10.02 9.79 6 549830 84 110039379
Radiation pneumonitis 10.02 9.79 5 549831 4531 110034932
Granuloma 10.02 9.79 20 549816 9470 110029993
Initial insomnia 10.01 9.79 87 549749 10302 110029161
Visual field tests abnormal 10.01 9.79 4 549832 21 110039442
Pain in jaw 9.99 9.79 329 549507 50848 109988615
Extremity contracture 9.99 9.79 25 549811 1736 110037727
Intercepted medication error 9.97 9.79 20 549816 1196 110038267
Postmortem blood drug level 9.97 9.79 10 549826 310 110039153
Tooth disorder 9.96 9.79 204 549632 29305 110010158
Detoxification 9.96 9.79 6 549830 85 110039378
Urine bilirubin increased 9.94 9.79 7 549829 131 110039332
Rash erythematous 9.94 9.79 500 549336 81332 109958131
Postmortem blood drug level abnormal 9.92 9.79 14 549822 626 110038837
Dysgraphia 9.90 9.79 48 549788 4657 110034806
Internal hernia 9.89 9.79 5 549831 49 110039414
Blood glucose increased 9.88 9.79 776 549060 131720 109907743
Sluggishness 9.87 9.79 68 549768 7499 110031964
Hypoproteinaemia 9.86 9.79 9 549827 5936 110033527
Retroplacental haematoma 9.81 9.79 7 549829 134 110039329
Multifocal motor neuropathy 9.81 9.79 7 549829 134 110039329
Psoriasis 9.81 9.79 816 549020 139177 109900286
Loss of control of legs 9.80 9.79 28 549808 2104 110037359
Infection reactivation 9.80 9.79 4 549832 4077 110035386

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Trismus 50.34 28.57 21 455 157 113320
Muscle tone disorder 29.33 28.57 12 464 84 113393

Pharmacologic Action:

SourceCodeDescription
ATC N02BF01 NERVOUS SYSTEM
ANALGESICS
OTHER ANALGESICS AND ANTIPYRETICS
Gabapentinoids
FDA PE N0000008486 Decreased Central Nervous System Disorganized Electrical Activity
MeSH PA D000700 Analgesics
MeSH PA D000927 Anticonvulsants
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014151 Anti-Anxiety Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018689 Sensory System Agents
MeSH PA D018691 Excitatory Amino Acid Antagonists
MeSH PA D018692 Antimanic Agents
CHEBI has role CHEBI:35469 antidepressant
CHEBI has role CHEBI:35474 anxiolytic drug
CHEBI has role CHEBI:35476 antipsychotic agent
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35623 anticonvulsant
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:35705 immunosuppressive agent
CHEBI has role CHEBI:38215 calcium channel blocker
CHEBI has role CHEBI:62868 hepatoprotective agent
CHEBI has role CHEBI:63726 neuroprotective agent
CHEBI has role CHEBI:64946 anti-HIV agent
CHEBI has role CHEBI:73336 vulnerary
CHEBI has role CHEBI:75835 anti-anaemic agent
CHEBI has role CHEBI:78298 environmental contaminant

Related Drugs by ATC class:

N02BF Gabapentinoids 2 drugs
mirogabalinpregabalin

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Postherpetic neuralgia indication 2177002
Restless legs indication 32914008 DOID:0050425
Partial Epilepsy Treatment Adjunct indication
Alcohol use disorder off-label use 7200002
Menopausal night sweats off-label use 42984000
Chronic cough off-label use 68154008
Chronic pain off-label use 82423001
Insomnia off-label use 193462001
Anxiety disorder off-label use 197480006 DOID:2030
Menopausal flushing off-label use 198436008
Fibromyalgia off-label use 203082005 DOID:631
Neuropathic pain off-label use 247398009
Chronic pruritus off-label use 418363000
Refractory pruritis off-label use 418363000
Post-stroke nausea off-label use 422587007
Essential tremor off-label use 609558009 DOID:4990
Intractable hiccups off-label use 716771000
Acute postoperative pain off-label use 107401000119105
Suicidal thoughts contraindication 6471006
Depressive disorder contraindication 35489007
Kidney disease contraindication 90708001 DOID:557




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.02 acidic
pKa2 10.31 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Voltage-dependent calcium channel subunit alpha-2/delta-2 Ion channel MODULATOR IC50 6.93 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Voltage-dependent calcium channel subunit alpha-2/delta-1 Ion channel MODULATOR IC50 7.26 WOMBAT-PK CHEMBL
Adenosine receptor A1 GPCR WOMBAT-PK
Gamma-aminobutyric acid type B receptor subunit 2 GPCR WOMBAT-PK
Glutamate receptor ionotropic, NMDA 3A Ion channel WOMBAT-PK
Large neutral amino acids transporter small subunit 1 Transporter IC50 4.52 WOMBAT-PK
Sodium channel protein type 5 subunit alpha Ion channel WOMBAT-PK
Potassium voltage-gated channel subfamily KQT member 3 Ion channel ACTIVATOR EC50 8.28 IUPHAR
Potassium voltage-gated channel subfamily KQT member 5 Ion channel ACTIVATOR EC50 8.72 IUPHAR
Alpha-2A adrenergic receptor GPCR WOMBAT-PK
Voltage-dependent calcium channel subunit alpha-2/delta-1 Ion channel Ki 6.92 CHEMBL
Uncharacterized protein; Voltage-dependent calcium channel alpha-2 delta subunit Ion channel IC50 7.15 CHEMBL

External reference:

IDSource
4020833 VUID
N0000148345 NUI
D00332 KEGG_DRUG
4020833 VANDF
C0060926 UMLSCUI
CHEBI:42797 CHEBI
GBN PDB_CHEM_ID
CHEMBL940 ChEMBL_ID
DB00996 DRUGBANK_ID
D000077206 MESH_DESCRIPTOR_UI
3446 PUBCHEM_CID
5094 INN_ID
5483 IUPHAR_LIGAND_ID
C081867 MESH_SUPPLEMENTAL_RECORD_UI
6CW7F3G59X UNII
196498 RXNORM
2269 MMSL
4770 MMSL
60712 MMSL
d03182 MMSL
004415 NDDF
108402001 SNOMEDCT_US
386845007 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Neurontin HUMAN PRESCRIPTION DRUG LABEL 1 0071-0401 TABLET, FILM COATED 800 mg ORAL NDA 30 sections
Neurontin HUMAN PRESCRIPTION DRUG LABEL 1 0071-0513 TABLET, FILM COATED 600 mg ORAL NDA 30 sections
Neurontin HUMAN PRESCRIPTION DRUG LABEL 1 0071-0803 CAPSULE 100 mg ORAL NDA 30 sections
Neurontin HUMAN PRESCRIPTION DRUG LABEL 1 0071-0805 CAPSULE 300 mg ORAL NDA 30 sections
Neurontin HUMAN PRESCRIPTION DRUG LABEL 1 0071-0806 CAPSULE 400 mg ORAL NDA 30 sections
Neurontin HUMAN PRESCRIPTION DRUG LABEL 1 0071-2012 SOLUTION 250 mg ORAL NDA 30 sections
Gabapentin HUMAN PRESCRIPTION DRUG LABEL 1 0121-1067 SOLUTION 250 mg ORAL ANDA 24 sections
Gabapentin HUMAN PRESCRIPTION DRUG LABEL 1 0121-2134 SOLUTION 250 mg ORAL ANDA 24 sections
Gabapentin HUMAN PRESCRIPTION DRUG LABEL 1 0121-4067 SOLUTION 250 mg ORAL ANDA 24 sections
GABAPENTIN HUMAN PRESCRIPTION DRUG LABEL 1 0440-5562 TABLET, FILM COATED 600 mg ORAL ANDA 24 sections
GABAPENTIN HUMAN PRESCRIPTION DRUG LABEL 1 0440-5563 TABLET, FILM COATED 800 mg ORAL ANDA 24 sections
Gabapentin HUMAN PRESCRIPTION DRUG LABEL 1 0440-7559 CAPSULE 300 mg ORAL ANDA 14 sections
Gabapentin HUMAN PRESCRIPTION DRUG LABEL 1 0480-3494 CAPSULE 100 mg ORAL ANDA 27 sections
Gabapentin HUMAN PRESCRIPTION DRUG LABEL 1 0480-3495 CAPSULE 300 mg ORAL ANDA 27 sections
Gabapentin HUMAN PRESCRIPTION DRUG LABEL 1 0480-3496 CAPSULE 400 mg ORAL ANDA 27 sections
Gabapentin HUMAN PRESCRIPTION DRUG LABEL 1 0904-6665 CAPSULE 100 mg ORAL ANDA 30 sections
Gabapentin HUMAN PRESCRIPTION DRUG LABEL 1 0904-6666 CAPSULE 300 mg ORAL ANDA 30 sections
Gabapentin HUMAN PRESCRIPTION DRUG LABEL 1 0904-6667 CAPSULE 400 mg ORAL ANDA 30 sections
Gabapentin HUMAN PRESCRIPTION DRUG LABEL 1 0904-6823 TABLET, FILM COATED 600 mg ORAL ANDA 30 sections
Gabapentin HUMAN PRESCRIPTION DRUG LABEL 1 0904-7108 TABLET, FILM COATED 800 mg ORAL ANDA 30 sections
Gabapentin Human Prescription Drug Label 1 0904-7613 CAPSULE 100 mg ORAL ANDA 30 sections
Gabapentin Human Prescription Drug Label 1 0904-7614 CAPSULE 300 mg ORAL ANDA 30 sections
Gabapentin Human Prescription Drug Label 1 0904-7615 CAPSULE 400 mg ORAL ANDA 30 sections
Gabapentin HUMAN PRESCRIPTION DRUG LABEL 1 10135-644 CAPSULE 100 mg ORAL ANDA 30 sections
Gabapentin HUMAN PRESCRIPTION DRUG LABEL 1 10135-645 CAPSULE 300 mg ORAL ANDA 30 sections
Gabapentin HUMAN PRESCRIPTION DRUG LABEL 1 10135-646 CAPSULE 400 mg ORAL ANDA 30 sections
Gabapentin HUMAN PRESCRIPTION DRUG LABEL 1 10135-647 TABLET 600 mg ORAL ANDA 30 sections
Gabapentin HUMAN PRESCRIPTION DRUG LABEL 1 10135-648 TABLET 800 mg ORAL ANDA 30 sections
Gabapentin HUMAN PRESCRIPTION DRUG LABEL 1 10544-011 CAPSULE 300 mg ORAL ANDA 23 sections
Gabapentin Human Prescription Drug Label 1 10544-185 CAPSULE 100 mg ORAL ANDA 26 sections