gabapentin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
gabamimetic agents	1264	60142-96-3

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: gabapentin gabamox gabapen neurontin gabapentine	The mechanism by which gabapentin exerts its analgesic action is unknown, but in animal models of analgesia, gabapentin prevents allodynia (pain-related behavior in response to a normally innocuous stimulus) and hyperalgesia (exaggerated response to painful stimuli). In particular, gabapentin prevents pain-related responses in several models of neuropathic pain in rats or mice (e.g., spinal nerve ligation models, streptozocin-induced diabetes model, spinal cord injury model, acute herpes zoster infection model). Gabapentin also decreases pain-related responses after peripheral inflammation (carrageenan footpad test, late phase of formalin test). Gabapentin did not alter immediate pain-related behaviors (rat tail flick test, formalin footpad acute phase, acetic acid abdominal constriction test, footpad heat irradiation test). The mechanism by which gabapentin exerts its anticonvulsant action is unknown, but in animal test systems designed to detect anticonvulsant activity, gabapentin prevents seizures as do other marketed anticonvulsants. Gabapentin exhibits antiseizure activity in mice and rats in both the maximal electroshock and pentylenetetrazole seizure models and other preclinical models (e.g., strains with genetic epilepsy, etc.). Gabapentin is structurally related to the neurotransmitter GABA (gamma-aminobutyric acid) but it does not modify GABAA or GABAB radioligand binding, it is not converted metabolically into GABA or a GABA agonist, and it is not an inhibitor of GABA uptake or degradation. Gabapentin was tested in radioligand binding assays at concentrations up to 100 uM and did not exhibit affinity for a number of other common receptor sites, including benzodiazepine, glutamate, N-methyl-D-aspartate (NMDA), quisqualate, kainate, strychnine-insensitive or strychnine-sensitive glycine, alpha 1, alpha 2, or beta adrenergic, adenosine A1 or A2, cholinergic muscarinic or nicotinic, dopamine D1 or D2, histamine H1, serotonin S1 or S2, opiate mu, delta or kappa, cannabinoid 1, voltage-sensitive calcium channel sites labeled with nitrendipine or diltiazem, or at voltage-sensitive sodium channel sites labeled with batrachotoxinin A 20-alpha-benzoate. Furthermore, gabapentin did not alter the cellular uptake of dopamine, noradrenaline, or serotonin. In vitro studies with radiolabeled gabapentin have revealed a gabapentin binding site in areas of rat brain including neocortex and hippocampus. A high-affinity binding protein in animal brain tissue has been identified as an auxiliary subunit of voltage-activated calcium channels. Molecular weight: 171.24 Formula: C9H17NO2 CLOGP: -0.66 LIPINSKI: 0 HAC: 3 HDO: 2 TPSA: 63.32 ALOGS: -1.60 ROTB: 3 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

gabapentin
gabamox
gabapen
neurontin
gabapentine

The mechanism by which gabapentin exerts its analgesic action is unknown, but in animal models of analgesia, gabapentin prevents allodynia (pain-related behavior in response to a normally innocuous stimulus) and hyperalgesia (exaggerated response to painful stimuli). In particular, gabapentin prevents pain-related responses in several models of neuropathic pain in rats or mice (e.g., spinal nerve ligation models, streptozocin-induced diabetes model, spinal cord injury model, acute herpes zoster infection model). Gabapentin also decreases pain-related responses after peripheral inflammation (carrageenan footpad test, late phase of formalin test). Gabapentin did not alter immediate pain-related behaviors (rat tail flick test, formalin footpad acute phase, acetic acid abdominal constriction test, footpad heat irradiation test). The mechanism by which gabapentin exerts its anticonvulsant action is unknown, but in animal test systems designed to detect anticonvulsant activity, gabapentin prevents seizures as do other marketed anticonvulsants. Gabapentin exhibits antiseizure activity in mice and rats in both the maximal electroshock and pentylenetetrazole seizure models and other preclinical models (e.g., strains with genetic epilepsy, etc.). Gabapentin is structurally related to the neurotransmitter GABA (gamma-aminobutyric acid) but it does not modify GABAA or GABAB radioligand binding, it is not converted metabolically into GABA or a GABA agonist, and it is not an inhibitor of GABA uptake or degradation. Gabapentin was tested in radioligand binding assays at concentrations up to 100 uM and did not exhibit affinity for a number of other common receptor sites, including benzodiazepine, glutamate, N-methyl-D-aspartate (NMDA), quisqualate, kainate, strychnine-insensitive or strychnine-sensitive glycine, alpha 1, alpha 2, or beta adrenergic, adenosine A1 or A2, cholinergic muscarinic or nicotinic, dopamine D1 or D2, histamine H1, serotonin S1 or S2, opiate mu, delta or kappa, cannabinoid 1, voltage-sensitive calcium channel sites labeled with nitrendipine or diltiazem, or at voltage-sensitive sodium channel sites labeled with batrachotoxinin A 20-alpha-benzoate. Furthermore, gabapentin did not alter the cellular uptake of dopamine, noradrenaline, or serotonin. In vitro studies with radiolabeled gabapentin have revealed a gabapentin binding site in areas of rat brain including neocortex and hippocampus. A high-affinity binding protein in animal brain tissue has been identified as an auxiliary subunit of voltage-activated calcium channels.

Molecular weight: 171.24
Formula: C9H17NO2
CLOGP: -0.66
LIPINSKI: 0
HAC: 3
HDO: 2
TPSA: 63.32
ALOGS: -1.60
ROTB: 3

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
1.80	g	O

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	3	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	10 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	100 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	116.79 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	60 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution)	0.71 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	1.70 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.97 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	5.30 hours	Lombardo F, Berellini G, Obach RS

Approvals:

Date	Agency	Company	Orphan
Dec. 30, 1993	FDA	PFIZER PHARMS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug hypersensitivity	1542.16	9.81	4613	362821	306074	62815514
Completed suicide	1030.68	9.81	2469	364965	143204	62978384
Pemphigus	1003.52	9.81	11	367423	183715	62937873
Drug ineffective for unapproved indication	958.50	9.81	1082	366352	32981	63088607
Glossodynia	746.54	9.81	82	367352	178794	62942794
Hand deformity	733.98	9.81	48	367386	159409	62962179
Systemic lupus erythematosus	716.95	9.81	165	367269	208753	62912835
Anti-cyclic citrullinated peptide antibody positive	653.93	9.81	3	367431	116209	63005379
Synovitis	585.47	9.81	177	367257	186741	62934847
Pericarditis	584.29	9.81	47	367387	131532	62990056
Contraindicated product administered	582.87	9.81	265	367169	217383	62904205
Maternal exposure during pregnancy	552.83	9.81	292	367142	219770	62901818
Arthropathy	480.80	9.81	392	367042	234400	62887188
Duodenal ulcer perforation	476.98	9.81	5	367429	87204	63034384
Multiple sclerosis relapse	458.46	9.81	924	366510	47554	63074034
Helicobacter infection	435.66	9.81	25	367409	92760	63028828
Rheumatoid factor positive	432.32	9.81	12	367422	84394	63037194
Wound	412.30	9.81	215	367219	163048	62958540
Somnolence	382.16	9.81	2041	365393	176644	62944944
Infusion related reaction	365.39	9.81	534	366900	244987	62876601
Toxicity to various agents	364.13	9.81	2564	364870	244686	62876902
Fall	345.83	9.81	3629	363805	388705	62732883
Hepatic enzyme increased	342.12	9.81	400	367034	201928	62919660
Joint swelling	320.98	9.81	908	366526	326758	62794830
Discomfort	317.63	9.81	300	367134	167074	62954514
Muscle injury	314.95	9.81	15	367419	65330	63056258
Folliculitis	306.90	9.81	27	367407	70290	63051298
Drug abuse	302.44	9.81	1016	366418	71502	63050086
Abdominal discomfort	290.68	9.81	922	366512	319963	62801625
Multiple sclerosis	290.61	9.81	513	366921	23859	63097729
General physical health deterioration	284.21	9.81	454	366980	200948	62920640
Depression	279.99	9.81	2022	365412	194470	62927118
Myoclonus	265.96	9.81	390	367044	15478	63106110
Swelling	250.89	9.81	789	366645	274589	62846999
Feeling abnormal	241.53	9.81	1578	365856	146814	62974774
Alopecia	238.63	9.81	1073	366361	336463	62785125
Therapeutic product effect decreased	237.00	9.81	475	366959	192712	62928876
Sleep disorder due to general medical condition, insomnia type	233.54	9.81	18	367416	52199	63069389
Tremor	226.12	9.81	1424	366010	130815	62990773
Suicidal ideation	213.72	9.81	820	366614	61601	63059987
Hypersensitivity	202.87	9.81	937	366497	291748	62829840
Liver injury	201.11	9.81	51	367383	60469	63061119
Product dose omission issue	198.75	9.81	2152	365282	232161	62889427
Exposure during pregnancy	192.84	9.81	380	367054	155167	62966421
Swollen joint count increased	188.90	9.81	4	367430	36050	63085538
Lower respiratory tract infection	188.68	9.81	296	367138	132011	62989577
Rheumatic fever	181.65	9.81	19	367415	43092	63078496
Irritable bowel syndrome	179.43	9.81	129	367305	82283	63039305
Dizziness	177.36	9.81	3481	363953	426444	62695144
Treatment failure	175.09	9.81	579	366855	198464	62923124
Impaired healing	170.75	9.81	205	367229	102337	63019251
Hallucination	169.85	9.81	698	366736	54119	63067469
Accidental death	164.20	9.81	116	367318	1860	63119728
Memory impairment	161.89	9.81	1096	366338	103162	63018426
Neuropathy peripheral	160.16	9.81	1167	366267	112500	63009088
Drug intolerance	158.55	9.81	1090	366344	307571	62814017
Drug withdrawal syndrome	153.69	9.81	424	367010	26770	63094818
C-reactive protein increased	152.79	9.81	194	367240	94513	63027075
Anxiety	149.86	9.81	1920	365514	215621	62905967
Balance disorder	149.81	9.81	918	366516	83504	63038084
Blister	148.39	9.81	332	367102	129482	62992106
Respiratory arrest	145.56	9.81	468	366966	32177	63089411
Product use issue	144.51	9.81	720	366714	219800	62901788
Withdrawal syndrome	144.37	9.81	342	367092	19655	63101933
Neuralgia	142.35	9.81	400	367034	25526	63096062
Vision blurred	141.90	9.81	965	366469	90959	63030629
Muscle spasms	138.28	9.81	1447	365987	154703	62966885
C-reactive protein abnormal	133.12	9.81	50	367384	46046	63075542
Drug dependence	128.83	9.81	372	367062	24111	63097477
Mental status changes	127.25	9.81	510	366924	39089	63082499
Febrile neutropenia	124.20	9.81	317	367117	118132	63003456
Product complaint	120.86	9.81	244	367190	12565	63109023
Seizure	114.55	9.81	1223	366211	131411	62990177
Cardio-respiratory arrest	111.45	9.81	660	366774	59299	63062289
Rash	111.31	9.81	2437	364997	558434	62563154
Pyrexia	109.63	9.81	1990	365444	468488	62653100
Respiratory depression	108.30	9.81	243	367191	13472	63108116
Rheumatoid arthritis	107.91	9.81	944	366490	252875	62868713
Ill-defined disorder	105.40	9.81	195	367239	81560	63040028
Gait disturbance	102.71	9.81	1559	365875	181619	62939969
Device expulsion	100.64	9.81	38	367396	34884	63086704
Pain in extremity	100.48	9.81	2570	364864	328916	62792672
Migraine	96.35	9.81	968	366466	102378	63019210
Hypoaesthesia	94.72	9.81	1434	366000	166959	62954629
Unresponsive to stimuli	94.22	9.81	417	367017	33399	63088189
Sopor	93.64	9.81	312	367122	21852	63099736
Urinary tract infection	86.39	9.81	2073	365361	262611	62858977
Infection	85.58	9.81	880	366554	228293	62893295
Blood cholesterol increased	85.06	9.81	270	367164	93762	63027826
Dyskinesia	84.94	9.81	389	367045	31613	63089975
Live birth	84.37	9.81	22	367412	25608	63095980
Drug use disorder	81.36	9.81	121	367313	4863	63116725
Hip arthroplasty	80.63	9.81	94	367340	47552	63074036
Lethargy	79.39	9.81	576	366858	55431	63066157
Interstitial lung disease	78.61	9.81	149	367285	61759	63059829
Plasma cell myeloma	75.13	9.81	408	367026	35497	63086091
Type 2 diabetes mellitus	74.88	9.81	161	367273	63707	63057881
Intentional product misuse	74.36	9.81	605	366829	60312	63061276
Cardiac arrest	72.40	9.81	837	366597	91708	63029880
Speech disorder	72.16	9.81	442	366992	40187	63081401
Paraesthesia	71.72	9.81	1292	366142	155674	62965914
Stomatitis	71.54	9.81	489	366945	138236	62983352
Myelosuppression	71.36	9.81	24	367410	23679	63097909
Back pain	69.74	9.81	2012	365422	262133	62859455
Mental disorder	69.49	9.81	316	367118	25603	63095985
Intentional product use issue	69.38	9.81	444	366990	127448	62994140
Bone erosion	69.27	9.81	10	367424	17707	63103881
Inadequate analgesia	68.68	9.81	85	367349	2858	63118730
Head injury	68.30	9.81	327	367107	27069	63094519
Muscular weakness	66.48	9.81	1036	366398	121317	63000271
Knee arthroplasty	65.77	9.81	134	367300	54072	63067516
Cytomegalovirus infection	65.23	9.81	20	367414	20932	63100656
Amnesia	64.61	9.81	546	366888	55039	63066549
Hepatic function abnormal	64.23	9.81	72	367362	37070	63084518
Insomnia	63.70	9.81	1664	365770	213588	62908000
Burning sensation	62.48	9.81	533	366901	53874	63067714
Therapeutic response unexpected	61.38	9.81	243	367191	18516	63103072
Intervertebral disc protrusion	61.30	9.81	286	367148	23423	63098165
Premature baby	60.69	9.81	22	367412	20713	63100875
Muscle twitching	60.55	9.81	250	367184	19418	63102170
Overdose	60.10	9.81	968	366466	114110	63007478
Vertigo	59.73	9.81	569	366865	59318	63062270
Sleep apnoea syndrome	58.91	9.81	328	367106	28805	63092783
Sedation	58.42	9.81	405	367029	38404	63083184
Trigeminal neuralgia	58.25	9.81	86	367348	3433	63118155
Off label use	58.23	9.81	3252	364182	671210	62450378
Influenza like illness	58.03	9.81	617	366817	66207	63055381
Gastrointestinal disorder	57.54	9.81	484	366950	130755	62990833
Feeling drunk	57.06	9.81	93	367341	4049	63117539
Coordination abnormal	56.52	9.81	192	367242	13581	63108007
Crying	56.30	9.81	276	367158	23067	63098521
Urinary incontinence	56.05	9.81	347	367087	31667	63089921
Hypersomnia	55.98	9.81	230	367204	17825	63103763
Hyperhidrosis	55.91	9.81	906	366528	106930	63014658
Back disorder	55.66	9.81	165	367269	10852	63110736
Cardiac failure	55.52	9.81	296	367138	88846	63032742
Full blood count decreased	55.31	9.81	297	367137	25727	63095861
Mucosal inflammation	55.26	9.81	118	367316	46810	63074778
Spinal operation	54.94	9.81	137	367297	8134	63113454
Pancytopenia	54.90	9.81	332	367102	96601	63024987
Malignant neoplasm progression	54.37	9.81	267	367167	81854	63039734
Anaemia	53.77	9.81	1290	366144	292140	62829448
Psoriatic arthropathy	53.67	9.81	310	367124	91210	63030378
Neck pain	53.34	9.81	625	366809	68693	63052895
Macular degeneration	53.24	9.81	38	367396	24338	63097250
Arthralgia	53.24	9.81	2725	364709	566985	62554603
Surgery	52.43	9.81	372	367062	35540	63086048
Death	52.25	9.81	2658	364776	371723	62749865
Pulmonary fibrosis	52.15	9.81	94	367340	39715	63081873
Drug tolerance decreased	52.07	9.81	18	367416	17455	63104133
Anticipatory anxiety	51.94	9.81	49	367385	1202	63120386
Nervousness	51.88	9.81	332	367102	30647	63090941
Confusional state	51.66	9.81	1760	365674	234620	62886968
Foetal exposure during pregnancy	50.98	9.81	66	367368	31896	63089692
Drug-induced liver injury	50.89	9.81	97	367337	40125	63081463
Hallucination, visual	50.78	9.81	234	367200	19064	63102524
Pleural fibrosis	50.63	9.81	80	367354	3392	63118196
Rheumatoid nodule	50.55	9.81	18	367416	17137	63104451
Presbyacusis	50.31	9.81	72	367362	2793	63118795
Nasopharyngitis	49.02	9.81	1109	366325	253148	62868440
Hepatotoxicity	48.94	9.81	87	367347	36954	63084634
Euphoric mood	48.39	9.81	95	367339	4792	63116796
Pregnancy	48.23	9.81	87	367347	36749	63084839
Suspected suicide	48.13	9.81	113	367321	6455	63115133
Therapeutic response decreased	47.40	9.81	189	367245	61336	63060252
Blood magnesium increased	47.09	9.81	72	367362	2966	63118622
Pleural thickening	47.07	9.81	70	367364	2813	63118775
Sinusitis	47.04	9.81	977	366457	225676	62895912
Poisoning	46.88	9.81	180	367254	13520	63108068
Thrombocytopenia	46.80	9.81	605	366829	150552	62971036
Restless legs syndrome	46.06	9.81	221	367213	18310	63103278
Disturbance in attention	45.91	9.81	378	367056	37811	63083777
Diplopia	45.90	9.81	264	367170	23464	63098124
Red blood cell sedimentation rate abnormal	45.67	9.81	29	367405	19753	63101835
Hypercholesterolaemia	45.63	9.81	34	367400	21300	63100288
Breast cancer stage III	45.27	9.81	4	367430	10382	63111206
Ataxia	45.10	9.81	191	367243	15004	63106584
Drug resistance	44.76	9.81	40	367394	22893	63098695
Ankle fracture	44.42	9.81	213	367221	17642	63103946
Myocardial stunning	43.91	9.81	21	367413	152	63121436
Nightmare	43.51	9.81	223	367211	18971	63102617
Pleural effusion	43.02	9.81	339	367095	92871	63028717
Mood altered	42.74	9.81	184	367250	14559	63107029
Multiple organ dysfunction syndrome	42.67	9.81	176	367258	56576	63065012
Drug ineffective	42.17	9.81	5352	362082	1039413	62082175
Anger	40.47	9.81	161	367273	12295	63109293
Impaired driving ability	40.28	9.81	84	367350	4427	63117161
Concussion	39.82	9.81	131	367303	9113	63112475
Hyperaesthesia	39.76	9.81	132	367302	9226	63112362
Limb injury	39.60	9.81	268	367166	25209	63096379
Hypermobility syndrome	39.57	9.81	35	367399	788	63120800
Joint injury	39.55	9.81	300	367134	29272	63092316
Musculoskeletal stiffness	39.43	9.81	792	366642	183826	62937762
Pre-existing condition improved	39.32	9.81	121	367313	8123	63113465
Nausea	38.33	9.81	5569	361865	848902	62272686
Coma	37.65	9.81	552	366882	63812	63057776
Blood lactate dehydrogenase increased	37.63	9.81	47	367387	23069	63098519
Bone marrow failure	37.62	9.81	70	367364	29220	63092368
Agitation	37.56	9.81	519	366915	59238	63062350
Mental impairment	37.54	9.81	172	367262	13979	63107609
Therapy non-responder	37.42	9.81	271	367163	75630	63045958
Accidental poisoning	36.96	9.81	30	367404	598	63120990
Accidental overdose	36.72	9.81	246	367188	23063	63098525
Irritability	36.65	9.81	311	367123	31383	63090205
Depressed level of consciousness	36.16	9.81	532	366902	61546	63060042
Serotonin syndrome	36.16	9.81	287	367147	28395	63093193
Dislocation of vertebra	35.88	9.81	4	367430	8631	63112957
Neutropenia	35.52	9.81	757	366677	174248	62947340
Anaphylactic shock	35.47	9.81	51	367383	23582	63098006
Drug screen positive	35.28	9.81	70	367364	3559	63118029
Brain injury	35.12	9.81	105	367329	6938	63114650
Asthenia	35.10	9.81	2625	364809	380979	62740609
Adjustment disorder with depressed mood	35.07	9.81	8	367426	10196	63111392
Premature delivery	34.94	9.81	77	367357	30204	63091384
Epigastric discomfort	34.69	9.81	102	367332	6678	63114910
Lupus-like syndrome	34.53	9.81	23	367411	15272	63106316
Incoherent	34.36	9.81	79	367355	4451	63117137
Bradyphrenia	33.81	9.81	103	367331	6877	63114711
Premature labour	33.77	9.81	15	367419	12489	63109099
Eosinophilic colitis	33.69	9.81	18	367416	169	63121419
Stiff person syndrome	33.56	9.81	22	367412	310	63121278
Nerve injury	33.48	9.81	130	367304	9816	63111772
Congenital absence of vertebra	33.47	9.81	12	367422	36	63121552
Neovascularisation	33.26	9.81	37	367397	1108	63120480
Injury	33.06	9.81	268	367166	72979	63048609
Deafness neurosensory	32.86	9.81	81	367353	4774	63116814
Dysarthria	32.81	9.81	385	367049	42326	63079262
Cyst	32.79	9.81	165	367269	13934	63107654
Muscle tightness	32.58	9.81	146	367288	11754	63109834
Leukopenia	32.54	9.81	288	367146	77002	63044586
Atrial fibrillation	32.45	9.81	477	366957	116159	63005429
Granuloma skin	32.44	9.81	5	367429	8432	63113156
Pneumocystis jirovecii pneumonia	32.42	9.81	30	367404	16884	63104704
Prescription drug used without a prescription	32.10	9.81	53	367381	2333	63119255
Visual snow syndrome	31.66	9.81	12	367422	44	63121544
Loss of consciousness	31.46	9.81	901	366533	117220	63004368
Encephalopathy	31.40	9.81	352	367082	38268	63083320
Thrombotic microangiopathy	31.26	9.81	11	367423	10550	63111038
Complex regional pain syndrome	31.23	9.81	52	367382	2305	63119283
Limb discomfort	30.96	9.81	285	367149	29431	63092157
Rash maculo-papular	30.68	9.81	89	367345	31807	63089781
Wheezing	30.55	9.81	380	367054	95215	63026373
Thinking abnormal	30.22	9.81	132	367302	10511	63111077
Panniculitis	30.21	9.81	14	367420	11371	63110217
Somatic delusion	30.12	9.81	26	367408	566	63121022
Condition aggravated	30.04	9.81	1965	365469	400252	62721336
Nerve compression	29.96	9.81	118	367316	8969	63112619
Peroneal nerve palsy	29.95	9.81	78	367356	4757	63116831
Haemophagocytic lymphohistiocytosis	29.90	9.81	12	367422	10615	63110973
Visual impairment	29.83	9.81	669	366765	83777	63037811
Hypokalaemia	29.76	9.81	422	367012	103382	63018206
Headache	29.62	9.81	4138	363296	629103	62492485
Body height decreased	29.38	9.81	126	367308	9952	63111636
Intervertebral disc degeneration	29.11	9.81	173	367261	15559	63106029
Dysstasia	29.02	9.81	216	367218	20950	63100638
Diabetic neuropathy	28.83	9.81	68	367366	3896	63117692
X-ray abnormal	28.60	9.81	6	367428	8104	63113484
Tooth loss	28.50	9.81	96	367338	6760	63114828
Thrombosis	28.49	9.81	530	366904	64225	63057363
Hyperreflexia	28.22	9.81	87	367347	5847	63115741
Tinnitus	28.19	9.81	323	367111	35305	63086283
Paranoia	28.10	9.81	138	367296	11541	63110047
Lymphoedema	28.02	9.81	138	367296	11554	63110034
Central nervous system lesion	28.01	9.81	129	367305	10506	63111082
Focal dyscognitive seizures	27.98	9.81	56	367378	2865	63118723
Somatic symptom disorder	27.92	9.81	53	367381	2607	63118981
Paradoxical drug reaction	27.82	9.81	69	367365	4083	63117505
Breast cancer stage II	27.81	9.81	8	367426	8728	63112860
Pituitary tumour benign	27.76	9.81	45	367389	1950	63119638
Pulmonary toxicity	27.73	9.81	10	367424	9445	63112143
Tardive dyskinesia	27.70	9.81	110	367324	8392	63113196
Chorea	27.33	9.81	40	367394	1584	63120004
Foot fracture	27.30	9.81	234	367200	23680	63097908
Neutropenic sepsis	27.20	9.81	33	367401	16405	63105183
Abortion spontaneous	27.05	9.81	161	367273	47034	63074554
Osteonecrosis of jaw	26.98	9.81	108	367326	35015	63086573
Drug diversion	26.46	9.81	30	367404	918	63120670
Congenital thrombocytopenia	26.35	9.81	11	367423	55	63121533
Therapy cessation	26.33	9.81	281	367153	30176	63091412
Gestational diabetes	26.16	9.81	8	367426	8388	63113200
Human epidermal growth factor receptor decreased	26.00	9.81	8	367426	12	63121576
Herpes zoster	25.97	9.81	643	366791	81819	63039769
Asterixis	25.81	9.81	36	367398	1363	63120225
Myoclonic epilepsy	25.77	9.81	34	367400	1220	63120368
Cognitive disorder	25.31	9.81	459	366975	55356	63066232
Dysphemia	25.29	9.81	51	367383	2624	63118964
Mobility decreased	25.19	9.81	522	366912	120637	63000951
Bone cyst	25.02	9.81	46	367388	2208	63119380
Cerebrovascular accident	25.01	9.81	810	366624	107214	63014374
Melaena	24.86	9.81	91	367343	30274	63091314
Hepatic failure	24.72	9.81	114	367320	35542	63086046
Rib deformity	24.63	9.81	17	367417	262	63121326
Eosinophilia	24.54	9.81	60	367374	22696	63098892
Bone density decreased	24.53	9.81	29	367405	14583	63107005
Disorientation	24.53	9.81	342	367092	39110	63082478
Skin reaction	24.37	9.81	30	367404	14819	63106769
Bipolar disorder	24.36	9.81	101	367333	7859	63113729
Substance abuse	24.29	9.81	72	367362	4735	63116853
Injection site mass	24.24	9.81	188	367246	18468	63103120
Illness	24.24	9.81	409	367025	48650	63072938
Skin necrosis	24.16	9.81	27	367407	13923	63107665
Anorgasmia	23.86	9.81	23	367411	580	63121008
Secondary progressive multiple sclerosis	23.80	9.81	35	367399	1392	63120196
Panic attack	23.68	9.81	215	367219	22116	63099472
Drug reaction with eosinophilia and systemic symptoms	23.56	9.81	108	367326	33728	63087860
Agranulocytosis	23.55	9.81	71	367363	25063	63096525
Exposure via ingestion	23.48	9.81	52	367382	2857	63118731
Therapy interrupted	23.37	9.81	289	367145	32166	63089422
Pollakiuria	23.34	9.81	256	367178	27681	63093907
Dry mouth	23.30	9.81	603	366831	77260	63044328
Oesophageal spasm	23.18	9.81	54	367380	3069	63118519
Transaminases increased	23.13	9.81	98	367336	31269	63090319
Blood parathyroid hormone decreased	23.09	9.81	14	367420	9777	63111811
Depressed mood	22.84	9.81	343	367091	39848	63081740
Dysphagia	22.84	9.81	673	366761	87912	63033676
Burns second degree	22.76	9.81	41	367393	1937	63119651
Urticaria	22.65	9.81	759	366675	165043	62956545
Adverse event	22.55	9.81	266	367168	67293	63054295
Red blood cell sedimentation rate increased	22.18	9.81	156	367278	43826	63077762
Micturition urgency	22.02	9.81	112	367322	9499	63112089
Obstructive airways disorder	21.99	9.81	55	367379	20644	63100944
Cervical spinal stenosis	21.96	9.81	43	367391	2165	63119423
Device difficult to use	21.91	9.81	25	367409	12771	63108817
Ascites	21.76	9.81	142	367292	40586	63081002
Psychomotor hyperactivity	21.52	9.81	120	367314	10543	63111045
Chronic obstructive pulmonary disease	21.32	9.81	494	366940	62192	63059396
Diffuse axonal injury	21.27	9.81	11	367423	96	63121492
Foot deformity	21.17	9.81	86	367348	27767	63093821
Hypopnoea	21.16	9.81	59	367375	3747	63117841
Constipation	20.98	9.81	1542	365892	223401	62898187
Blood pressure systolic abnormal	20.98	9.81	28	367406	13358	63108230
Creatinine renal clearance decreased	20.92	9.81	39	367395	16269	63105319
Pneumonia	20.84	9.81	2981	364453	453786	62667802
Transplant rejection	20.80	9.81	19	367415	10761	63110827
Somnambulism	20.78	9.81	75	367359	5468	63116120
Sensory disturbance	20.76	9.81	143	367291	13529	63108059
Stress	20.63	9.81	522	366912	66645	63054943
Metastases to liver	20.59	9.81	69	367365	23570	63098018
Cytomegalovirus viraemia	20.29	9.81	4	367430	5645	63115943
Psychotic disorder due to a general medical condition	20.19	9.81	15	367419	261	63121327
Low birth weight baby	20.14	9.81	8	367426	7121	63114467
Hypokinesia	20.13	9.81	144	367290	13792	63107796
Autonomic nervous system imbalance	20.13	9.81	48	367386	2770	63118818
Haematotoxicity	19.98	9.81	15	367419	9361	63112227
Bronchitis	19.90	9.81	899	366535	124036	62997552
Device adhesion issue	19.87	9.81	3	367431	5138	63116450
Cystitis	19.84	9.81	437	366997	54554	63067034
Myelodysplastic syndrome	19.83	9.81	42	367392	16712	63104876
Pruritus	19.72	9.81	1812	365622	359641	62761947
Metabolic encephalopathy	19.61	9.81	76	367358	5733	63115855
Dental caries	19.60	9.81	118	367316	10661	63110927
Drug titration error	19.58	9.81	24	367410	799	63120789
Jaundice	19.41	9.81	95	367339	29156	63092432
Hypertension	19.41	9.81	1373	366061	277930	62843658
Joint destruction	19.40	9.81	6	367428	6246	63115342
Arteriovenous malformation	19.37	9.81	31	367403	1329	63120259
JC polyomavirus test positive	19.18	9.81	32	367402	1421	63120167
Fatigue	19.15	9.81	5586	361848	882442	62239146
Pulmonary aplasia	19.12	9.81	6	367428	10	63121578
Foetal growth restriction	18.96	9.81	10	367424	7543	63114045
Anal incontinence	18.87	9.81	139	367295	13437	63108151
Device use error	18.86	9.81	5	367429	5756	63115832
Urinary retention	18.56	9.81	262	367172	30039	63091549
Spinal disorder	18.39	9.81	109	367325	9793	63111795
Spinal osteoarthritis	18.28	9.81	158	367276	16028	63105560
Facial pain	18.19	9.81	114	367320	10447	63111141
Toxic skin eruption	18.18	9.81	29	367405	12856	63108732
Toxic epidermal necrolysis	18.16	9.81	80	367354	25254	63096334
Blood potassium decreased	18.15	9.81	343	367091	41683	63079905
Hepatocellular injury	18.13	9.81	89	367345	27292	63094296
Hip fracture	18.12	9.81	255	367179	29219	63092369
Chronic sinusitis	18.04	9.81	29	367405	12814	63108774
White blood cell count decreased	18.01	9.81	981	366453	138123	62983465
Jaundice cholestatic	17.95	9.81	10	367424	7314	63114274
Drug abuser	17.95	9.81	47	367387	2876	63118712
Persistent depressive disorder	17.87	9.81	26	367408	1024	63120564
Laboratory test abnormal	17.84	9.81	236	367198	26676	63094912
Economic problem	17.75	9.81	37	367397	1949	63119639
Glycosylated haemoglobin decreased	17.68	9.81	19	367415	547	63121041
Facial spasm	17.63	9.81	21	367413	678	63120910
Sacroiliitis	17.63	9.81	50	367384	3207	63118381
Lip dry	17.31	9.81	40	367394	15430	63106158
Atonic urinary bladder	17.17	9.81	9	367425	81	63121507
Acute myeloid leukaemia	17.11	9.81	47	367387	17100	63104488
Acute respiratory distress syndrome	17.06	9.81	74	367360	23460	63098128
Bronchiectasis	17.06	9.81	43	367391	16099	63105489
Influenza	17.02	9.81	781	366653	107941	63013647
Septic shock	16.99	9.81	277	367157	66352	63055236
Bladder disorder	16.95	9.81	99	367335	8847	63112741
Maternal exposure timing unspecified	16.90	9.81	10	367424	7077	63114511
Psoriasis	16.88	9.81	639	366795	86318	63035270
Grip strength decreased	16.82	9.81	69	367365	22218	63099370
Hot flush	16.73	9.81	401	367033	50758	63070830
Head banging	16.71	9.81	16	367418	400	63121188
Drug screen false positive	16.69	9.81	23	367411	861	63120727
Subdural hygroma	16.67	9.81	13	367421	244	63121344
Osteosclerosis	16.66	9.81	55	367379	3833	63117755
Pulmonary tuberculosis	16.65	9.81	3	367431	4514	63117074
Erythema	16.64	9.81	839	366595	174912	62946676
Generalised tonic-clonic seizure	16.63	9.81	248	367186	28768	63092820
Gastrointestinal motility disorder	16.50	9.81	66	367368	5053	63116535
Lung disorder	16.49	9.81	257	367177	62004	63059584
Abortion induced	16.49	9.81	21	367413	10221	63111367
Epistaxis	16.42	9.81	309	367125	72416	63049172
Maternal exposure before pregnancy	16.41	9.81	12	367422	7591	63113997
Alcoholism	16.40	9.81	34	367400	1784	63119804
Blood potassium increased	16.33	9.81	170	367264	18139	63103449
Ligament sprain	16.09	9.81	128	367306	12672	63108916
Breast cancer stage I	16.04	9.81	10	367424	6879	63114709
Accidental exposure to product	15.97	9.81	93	367341	27312	63094276
Breakthrough pain	15.86	9.81	27	367407	1219	63120369
Diarrhoea	15.81	9.81	4505	362929	710861	62410727
Hyponatraemia	15.81	9.81	510	366924	111390	63010198
Nerve block	15.76	9.81	21	367413	761	63120827
Hostility	15.72	9.81	34	367400	1838	63119750
Blood lactic acid	15.71	9.81	9	367425	98	63121490
Cerebral infarction	15.62	9.81	78	367356	23815	63097773
Progressive multiple sclerosis	15.62	9.81	26	367408	1152	63120436
Cellulitis	15.61	9.81	601	366833	81357	63040231
Product use in unapproved indication	15.59	9.81	1221	366213	177859	62943729
Disorganised speech	15.56	9.81	27	367407	1238	63120350
Oesophageal obstruction	15.54	9.81	18	367416	564	63121024
Dependence	15.51	9.81	36	367398	2041	63119547
Pregnancy with contraceptive device	15.50	9.81	4	367430	4690	63116898
Unintentional medical device removal	15.50	9.81	8	367426	6107	63115481
Pre-eclampsia	15.47	9.81	18	367416	9115	63112473
Hyperbilirubinaemia	15.47	9.81	26	367408	11288	63110300
Stillbirth	15.44	9.81	10	367424	6740	63114848
Osteoporosis	15.42	9.81	236	367198	57102	63064486
Caesarean section	15.33	9.81	49	367385	16983	63104605
Genital haemorrhage	15.28	9.81	12	367422	7320	63114268
Seasonal allergy	15.28	9.81	187	367247	20763	63100825
Fluid retention	15.26	9.81	453	366981	59233	63062355
Basal cell carcinoma	15.25	9.81	97	367337	27894	63093694
Deprescribing error	15.24	9.81	6	367428	25	63121563
Nervous system disorder	15.24	9.81	171	367263	18595	63102993
Ejection fraction decreased	15.13	9.81	72	367362	22260	63099328
Tuberculosis	15.11	9.81	26	367408	11185	63110403
Dry eye	15.05	9.81	325	367109	40436	63081152
Postmortem blood drug level increased	15.00	9.81	18	367416	586	63121002
Postmortem blood drug level abnormal	14.82	9.81	14	367420	344	63121244
Abnormal dreams	14.81	9.81	108	367326	10408	63111180
Bradycardia	14.77	9.81	317	367117	72910	63048678
Medication overuse headache	14.74	9.81	21	367413	811	63120777
Pineal gland cyst	14.74	9.81	5	367429	12	63121576
Paralysis	14.71	9.81	103	367331	9797	63111791
Inflammation	14.67	9.81	363	367071	81910	63039678
Oesophageal pain	14.67	9.81	51	367383	3650	63117938
Sleep talking	14.59	9.81	23	367411	973	63120615
Cholestasis	14.55	9.81	105	367329	29329	63092259
Gastrointestinal toxicity	14.52	9.81	14	367420	7727	63113861
Intentional self-injury	14.51	9.81	219	367215	25468	63096120
Rib fracture	14.50	9.81	197	367237	22400	63099188
Spinal stenosis	14.48	9.81	141	367293	14784	63106804
Myotonia	14.44	9.81	10	367424	155	63121433
Kidney infection	14.44	9.81	201	367233	22975	63098613
Liver function test increased	14.37	9.81	121	367313	32690	63088898
Injection site induration	14.31	9.81	97	367337	9129	63112459
Graft versus host disease	14.18	9.81	11	367423	6752	63114836
Polyarthritis	14.16	9.81	23	367411	10123	63111465
Post herpetic neuralgia	14.16	9.81	36	367398	2163	63119425
Aphasia	14.13	9.81	269	367165	32731	63088857
Wrong patient received product	14.08	9.81	36	367398	2171	63119417
Electroencephalogram abnormal	14.03	9.81	50	367384	3622	63117966
Febrile bone marrow aplasia	14.03	9.81	13	367421	7312	63114276
Disturbance in social behaviour	13.99	9.81	3	367431	3990	63117598
Product availability issue	13.98	9.81	54	367380	4067	63117521
Toxicologic test abnormal	13.98	9.81	19	367415	702	63120886
Ageusia	13.96	9.81	131	367303	13597	63107991
Septic encephalopathy	13.89	9.81	8	367426	88	63121500
Facet joint syndrome	13.89	9.81	31	367403	12107	63109481
Oligohydramnios	13.80	9.81	10	367424	6356	63115232
Skin toxicity	13.80	9.81	5	367429	4709	63116879
Cytokine release syndrome	13.72	9.81	40	367394	14274	63107314
Intervertebral disc disorder	13.70	9.81	60	367374	4783	63116805
Mucocutaneous haemorrhage	13.66	9.81	8	367426	91	63121497
Myocardial infarction	13.63	9.81	708	366726	99185	63022403
Hypoxic-ischaemic encephalopathy	13.60	9.81	55	367379	4232	63117356
Carpal tunnel syndrome	13.57	9.81	182	367252	20635	63100953
Allodynia	13.54	9.81	20	367414	799	63120789
Hepatitis	13.53	9.81	156	367278	39632	63081956
Femoral artery dissection	13.48	9.81	6	367428	36	63121552
Drug eruption	13.40	9.81	104	367330	28590	63092998
Blood iron abnormal	13.40	9.81	3	367431	3873	63117715
Impaired gastric emptying	13.36	9.81	104	367330	10228	63111360
Pancreatitis chronic	13.31	9.81	38	367396	2446	63119142
Colitis	13.30	9.81	199	367235	48329	63073259
Shock haemorrhagic	13.29	9.81	23	367411	9872	63111716
Central nervous system infection	13.28	9.81	19	367415	737	63120851
Lymphoma	13.24	9.81	32	367402	12155	63109433
Post procedural infection	13.19	9.81	96	367338	9246	63112342
Disseminated intravascular coagulation	13.15	9.81	61	367373	18990	63102598
Post procedural complication	13.15	9.81	154	367280	16920	63104668
Hyperprolactinaemia	13.15	9.81	51	367383	3849	63117739
Tonic clonic movements	13.14	9.81	27	367407	1408	63120180
Dysgraphia	13.10	9.81	45	367389	3201	63118387
Drug screen negative	13.07	9.81	12	367422	284	63121304
Phobia	13.07	9.81	13	367421	341	63121247
Decreased interest	13.03	9.81	45	367389	3209	63118379
Pharyngitis	13.03	9.81	66	367368	20077	63101511
Peritonitis	13.02	9.81	53	367381	17101	63104487
Malignant urinary tract neoplasm	13.00	9.81	4	367430	6	63121582
Hyperacusis	13.00	9.81	34	367400	2079	63119509
Flushing	12.99	9.81	545	366889	74542	63047046
Acute generalised exanthematous pustulosis	12.99	9.81	28	367406	11071	63110517
Haemolysis	12.97	9.81	12	367422	6756	63114832
Peripheral venous disease	12.92	9.81	46	367388	15431	63106157
Osteopenia	12.90	9.81	173	367261	19612	63101976
Urinary occult blood positive	12.90	9.81	7	367427	68	63121520
Hepatitis C virus test positive	12.89	9.81	8	367426	102	63121486
Neurogenic bladder	12.79	9.81	45	367389	3240	63118348
Formication	12.78	9.81	54	367380	4237	63117351
Eyelid myoclonus	12.75	9.81	8	367426	104	63121484
Lung adenocarcinoma stage I	12.67	9.81	5	367429	21	63121567
Hereditary angioedema	12.63	9.81	81	367353	7481	63114107
Heteroplasia	12.63	9.81	4	367430	7	63121581
Schizophrenia	12.59	9.81	24	367410	9928	63111660
Conversion disorder	12.55	9.81	30	367404	1734	63119854
Normal newborn	12.52	9.81	18	367416	8323	63113265
Ligamentum flavum hypertrophy	12.47	9.81	3	367431	0	63121588
Pharyngeal neoplasm	12.47	9.81	3	367431	0	63121588
CSF neutrophil count increased	12.47	9.81	3	367431	0	63121588
Muscle relaxant drug level above therapeutic	12.47	9.81	3	367431	0	63121588
Glossopharyngeal neuralgia	12.47	9.81	3	367431	0	63121588
Epidermal naevus	12.47	9.81	3	367431	0	63121588
Turbinectomy	12.47	9.81	3	367431	0	63121588
Epstein-Barr virus infection	12.45	9.81	17	367417	8033	63113555
Night sweats	12.42	9.81	203	367231	48611	63072977
Transient ischaemic attack	12.37	9.81	296	367138	37457	63084131
Stereotypy	12.36	9.81	14	367420	428	63121160
Breast swelling	12.34	9.81	26	367408	1380	63120208
Blood potassium abnormal	12.34	9.81	38	367396	2552	63119036
Vascular malformation	12.30	9.81	13	367421	367	63121221
Posterior reversible encephalopathy syndrome	12.29	9.81	55	367379	17290	63104298
Prophylaxis	12.28	9.81	4	367430	8	63121580
Hepatitis cholestatic	12.26	9.81	13	367421	6865	63114723
Spinal cord injury	12.23	9.81	20	367414	873	63120715
Gait inability	12.22	9.81	397	367037	52562	63069026
Drug effective for unapproved indication	12.17	9.81	45	367389	3319	63118269
Neuroma	12.15	9.81	14	367420	436	63121152
Urinary hesitation	12.15	9.81	35	367399	2265	63119323
Incorrect route of product administration	12.13	9.81	101	367333	27351	63094237
Blood bilirubin increased	12.10	9.81	147	367287	36993	63084595
Product physical issue	12.09	9.81	59	367375	4921	63116667
Parapsoriasis	12.07	9.81	8	367426	115	63121473
Neutrophil count decreased	12.02	9.81	242	367192	56164	63065424
Sciatic nerve injury	12.01	9.81	15	367419	509	63121079
Vertebral foraminal stenosis	12.01	9.81	21	367413	969	63120619
Slow speech	11.97	9.81	27	367407	1502	63120086
Metastases to lung	11.95	9.81	36	367398	12714	63108874
Substance use	11.94	9.81	15	367419	512	63121076
Cardiotoxicity	11.90	9.81	19	367415	8419	63113169
Tooth disorder	11.88	9.81	229	367205	27928	63093660
Unevaluable event	11.81	9.81	385	367049	51001	63070587
Nephrogenic systemic fibrosis	11.81	9.81	55	367379	4501	63117087
Feeling of despair	11.79	9.81	35	367399	2304	63119284
Metabolic surgery	11.78	9.81	24	367410	1244	63120344
Respiratory rate decreased	11.73	9.81	46	367388	3489	63118099
Upper airway resistance syndrome	11.68	9.81	4	367430	10	63121578
Proteinuria	11.68	9.81	64	367370	19081	63102507
Internal hernia	11.64	9.81	6	367428	52	63121536
Naevus haemorrhage	11.61	9.81	8	367426	123	63121465
Movement disorder	11.59	9.81	183	367251	21478	63100110
Pharyngeal swelling	11.58	9.81	70	367364	6334	63115254
Paranasal cyst	11.56	9.81	13	367421	394	63121194
Face oedema	11.56	9.81	69	367365	20143	63101445
Narcolepsy	11.54	9.81	25	367409	1353	63120235
Connective tissue inflammation	11.54	9.81	6	367428	53	63121535
Dysphoria	11.47	9.81	58	367376	4908	63116680
Abnormal behaviour	11.46	9.81	181	367253	21245	63100343
Gastrointestinal haemorrhage	11.46	9.81	370	367064	80806	63040782
Urine amphetamine positive	11.44	9.81	6	367428	54	63121534
Increased tendency to bruise	11.40	9.81	102	367332	10450	63111138
Hepatic cirrhosis	11.38	9.81	90	367344	24644	63096944
Abdominal pain	11.38	9.81	1506	365928	291950	62829638
Metastases to bone	11.37	9.81	73	367361	20946	63100642
Neuromyelitis optica spectrum disorder	11.35	9.81	21	367413	1013	63120575
Intentional underdose	11.29	9.81	30	367404	1852	63119736
Alanine aminotransferase abnormal	11.25	9.81	6	367428	4498	63117090
Disease progression	11.24	9.81	588	366846	122170	62999418
Vulvar basal cell carcinoma	11.23	9.81	5	367429	30	63121558
Band sensation	11.22	9.81	19	367415	854	63120734
Proctitis	11.22	9.81	9	367425	5432	63116156
Congenital neuropathy	11.16	9.81	4	367430	12	63121576
Gastroschisis	11.15	9.81	13	367421	410	63121178
Face injury	11.13	9.81	43	367391	3239	63118349
Wrist fracture	11.12	9.81	124	367310	13463	63108125
Tumour lysis syndrome	11.09	9.81	22	367412	8968	63112620
Snoring	11.09	9.81	51	367383	4151	63117437
Injection site atrophy	11.06	9.81	16	367418	627	63120961
Prescribed underdose	11.06	9.81	114	367320	29575	63092013
Decubitus ulcer	11.01	9.81	101	367333	10419	63111169
Malignant polyp	10.98	9.81	9	367425	182	63121406
Pericardial effusion	10.96	9.81	116	367318	29942	63091646
Application site vesicles	10.86	9.81	25	367409	1410	63120178
Blood glucose decreased	10.83	9.81	176	367258	20776	63100812
Product adhesion issue	10.82	9.81	55	367379	4664	63116924
Blood pressure systolic increased	10.81	9.81	201	367233	47196	63074392
Pallor	10.73	9.81	119	367315	30449	63091139
Device dislocation	10.72	9.81	96	367338	25609	63095979
Dyspnoea	10.71	9.81	3546	363888	657767	62463821
Hepatitis acute	10.68	9.81	23	367411	9097	63112491
Unintended pregnancy	10.66	9.81	12	367422	6167	63115421
Concomitant disease aggravated	10.65	9.81	23	367411	9089	63112499
Peripheral swelling	10.65	9.81	1362	366072	264580	62857008
Tendon injury	10.62	9.81	30	367404	1920	63119668
Hypertonic bladder	10.57	9.81	45	367389	3543	63118045
Breast pain	10.53	9.81	87	367347	8711	63112877
Application site burn	10.52	9.81	18	367416	816	63120772
Femur fracture	10.51	9.81	174	367260	41582	63080006
Neck surgery	10.51	9.81	29	367405	1831	63119757
Dysphonia	10.50	9.81	355	367079	47259	63074329
Enamel anomaly	10.49	9.81	4	367430	15	63121573
Feeling of body temperature change	10.48	9.81	56	367378	4841	63116747
Uterine perforation	10.48	9.81	15	367419	6948	63114640
Screaming	10.47	9.81	42	367392	3220	63118368
Diabetic gastropathy	10.41	9.81	3	367431	3	63121585
Nervous system cyst	10.41	9.81	3	367431	3	63121585
Premature ageing	10.41	9.81	3	367431	3	63121585
Symptom masked	10.40	9.81	17	367417	742	63120846
Cervicogenic headache	10.29	9.81	4	367430	16	63121572
Graft versus host disease in gastrointestinal tract	10.26	9.81	3	367431	3238	63118350
Empty sella syndrome	10.25	9.81	5	367429	38	63121550
Ulcer	10.24	9.81	99	367335	26008	63095580
Fear of injection	10.23	9.81	16	367418	7148	63114440
Bladder spasm	10.22	9.81	28	367406	1760	63119828
Neurosis	10.19	9.81	10	367424	258	63121330
Myocardial oedema	10.16	9.81	9	367425	203	63121385
Product administration interrupted	10.15	9.81	55	367379	4781	63116807
Nerve root injury	10.14	9.81	5	367429	39	63121549
Toe operation	10.12	9.81	17	367417	759	63120829
Prescribed overdose	10.08	9.81	138	367296	34015	63087573
Suicide attempt	10.06	9.81	440	366994	60478	63061110
CSF white blood cell count increased	10.04	9.81	5	367429	40	63121548
Uveitis	10.02	9.81	38	367396	12515	63109073
Emotional disorder	10.01	9.81	120	367314	13259	63108329
Retroplacental haematoma	10.00	9.81	8	367426	156	63121432
Radiation necrosis	9.97	9.81	12	367422	392	63121196
Subileus	9.96	9.81	3	367431	3176	63118412
Gastric bypass	9.94	9.81	28	367406	1789	63119799
Hypoventilation	9.93	9.81	54	367380	4700	63116888
Lid lag	9.92	9.81	4	367430	18	63121570
Gout	9.91	9.81	119	367315	13152	63108436
Paraplegia	9.89	9.81	36	367398	2636	63118952
Inability to afford medication	9.88	9.81	33	367401	2314	63119274
Sudden onset of sleep	9.86	9.81	14	367420	539	63121049
Cardiogenic shock	9.84	9.81	62	367372	17870	63103718
CD8 lymphocytes decreased	9.83	9.81	8	367426	160	63121428
Aspergillus infection	9.82	9.81	20	367414	8073	63113515

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug hypersensitivity	835.75	10.48	1581	197799	78948	34678603
Completed suicide	558.23	10.48	1518	197862	96650	34660901
Drug ineffective for unapproved indication	423.68	10.48	596	198784	23119	34734432
Myoclonus	296.15	10.48	392	198988	14333	34743218
Somnolence	242.00	10.48	1262	198118	109854	34647697
Toxicity to various agents	236.44	10.48	1950	197430	198412	34559139
Sedation	183.24	10.48	384	198996	20622	34736929
Drug withdrawal syndrome	179.38	10.48	368	199012	19466	34738085
Drug dependence	168.98	10.48	405	198975	23812	34733739
Drug abuse	159.34	10.48	1039	198341	98057	34659494
Interstitial lung disease	156.17	10.48	89	199291	65193	34692358
Fall	144.25	10.48	1779	197601	201106	34556445
Multiple sclerosis relapse	138.55	10.48	260	199120	12873	34744678
Euphoric mood	135.33	10.48	164	199216	5477	34752074
Confusional state	122.04	10.48	1308	198072	142852	34614699
Febrile neutropenia	112.82	10.48	401	198979	136448	34621103
Neuropathy peripheral	112.58	10.48	837	198543	82426	34675125
Depression	111.50	10.48	940	198440	96158	34661393
Therapeutic product effect variable	110.58	10.48	100	199280	2356	34755195
Obsessive-compulsive disorder	107.07	10.48	145	199235	5419	34752132
Memory impairment	106.86	10.48	510	198870	42808	34714743
Hypoaesthesia	105.96	10.48	656	198724	60788	34696763
Withdrawal syndrome	103.20	10.48	223	199157	12232	34745319
Mental status changes	101.77	10.48	459	198921	37624	34719927
Pyrexia	101.36	10.48	1316	198064	331697	34425854
Hepatic function abnormal	101.14	10.48	64	199316	44299	34713252
Insomnia	99.94	10.48	968	198412	102939	34654612
Antipsychotic drug level below therapeutic	99.82	10.48	96	199284	2451	34755100
Pain in extremity	98.39	10.48	1129	198251	125384	34632167
Tremor	98.26	10.48	806	198574	81781	34675770
Disinhibition	98.04	10.48	106	199274	3120	34754431
Pain	95.62	10.48	1669	197711	203006	34554545
Cytomegalovirus infection	95.20	10.48	17	199363	26118	34731433
Anaemia	89.87	10.48	874	198506	232461	34525090
Nightmare	87.07	10.48	228	199152	14163	34743388
Gait disturbance	85.73	10.48	801	198579	84339	34673212
Respiratory arrest	84.91	10.48	351	199029	27692	34729859
Cardiac failure	83.70	10.48	255	199125	90993	34666558
C-reactive protein increased	83.15	10.48	112	199268	53986	34703565
Thrombocytopenia	80.46	10.48	541	198839	155706	34601845
Renal impairment	79.15	10.48	275	199105	94238	34663313
Muscle spasticity	78.21	10.48	129	199251	5759	34751792
Balance disorder	77.08	10.48	445	198935	40209	34717342
Drug resistance	75.00	10.48	27	199353	25900	34731651
Dizziness	73.01	10.48	1695	197685	216826	34540725
Increased appetite	72.12	10.48	142	199238	7287	34750264
Plasma cell myeloma	71.94	10.48	448	198932	41589	34715962
Neuralgia	71.44	10.48	219	199161	14894	34742657
Intervertebral disc degeneration	70.13	10.48	129	199251	6288	34751263
Muscle spasms	69.28	10.48	693	198687	74308	34683243
Right atrial hypertrophy	69.25	10.48	48	199332	757	34756794
Neutropenia	69.16	10.48	567	198813	156211	34601340
Mucosal inflammation	67.83	10.48	72	199308	38550	34719001
Overdose	67.79	10.48	806	198574	90253	34667298
Multiple sclerosis	66.93	10.48	129	199251	6516	34751035
Alanine aminotransferase increased	66.41	10.48	237	199143	80578	34676973
Anxiety	64.59	10.48	858	198522	98570	34658981
Hallucination	61.96	10.48	504	198876	50994	34706557
Appendicolith	61.23	10.48	145	199235	8456	34749095
Septic shock	60.13	10.48	209	199171	71625	34685926
Accidental death	59.88	10.48	72	199308	2384	34755167
Respiratory depression	58.67	10.48	215	199165	16030	34741521
Dysarthria	58.46	10.48	369	199011	34413	34723138
Product complaint	57.68	10.48	113	199267	5777	34751774
Disseminated intravascular coagulation	56.20	10.48	27	199353	21789	34735762
Myelosuppression	55.83	10.48	20	199360	19245	34738306
Intentional product misuse	55.75	10.48	448	198932	45163	34712388
Suicidal ideation	55.66	10.48	408	198972	39980	34717571
Feeling abnormal	54.44	10.48	576	198804	62659	34694892
Bronchial secretion retention	52.98	10.48	54	199326	1482	34756069
Prescription drug used without a prescription	50.65	10.48	62	199318	2092	34755459
Bronchial wall thickening	48.84	10.48	49	199331	1319	34756232
Bone marrow failure	48.66	10.48	57	199323	29196	34728355
Haemophagocytic lymphohistiocytosis	48.21	10.48	8	199372	12965	34744586
Ataxia	47.24	10.48	180	199200	13673	34743878
Drug reaction with eosinophilia and systemic symptoms	47.11	10.48	72	199308	32940	34724611
Constipation	46.41	10.48	1065	198315	135917	34621634
Right ventricular hypertrophy	45.91	10.48	50	199330	1484	34756067
Burning sensation	45.65	10.48	217	199163	18177	34739374
Back disorder	45.06	10.48	110	199270	6541	34751010
Myokymia	42.65	10.48	17	199363	75	34757476
Depressed level of consciousness	42.55	10.48	402	198978	42439	34715112
Appendicitis	42.22	10.48	182	199198	14625	34742926
Relapsing-remitting multiple sclerosis	41.95	10.48	40	199340	1010	34756541
Needle fatigue	41.90	10.48	37	199343	844	34756707
Amnesia	41.08	10.48	276	199104	26287	34731264
Serotonin syndrome	40.96	10.48	223	199157	19710	34737841
Fatigue	40.93	10.48	2541	196839	368112	34389439
Sleep apnoea syndrome	40.85	10.48	226	199154	20095	34737456
Malignant neoplasm progression	40.83	10.48	314	199066	87732	34669819
Infusion related reaction	40.70	10.48	160	199220	52897	34704654
Neutrophil count decreased	39.27	10.48	154	199226	50950	34706601
Melaena	39.16	10.48	90	199290	35290	34722261
Hypokalaemia	38.88	10.48	185	199195	58029	34699522
Aspergillus infection	38.56	10.48	11	199369	12243	34745308
Obstruction	38.05	10.48	61	199319	2658	34754893
Bronchopulmonary aspergillosis	37.98	10.48	18	199362	14641	34742910
Aspartate aminotransferase increased	37.75	10.48	229	199151	67554	34689997
Disease progression	37.73	10.48	414	198966	107663	34649888
General physical health deterioration	37.70	10.48	510	198870	127759	34629792
Vision blurred	37.38	10.48	414	198966	45549	34712002
Gait spastic	36.84	10.48	38	199342	1058	34756493
Eosinophilia	36.64	10.48	58	199322	26164	34731387
Metabolic acidosis	35.93	10.48	128	199252	43552	34713999
Hyperreflexia	35.73	10.48	65	199315	3141	34754410
Hepatic failure	35.72	10.48	91	199289	34440	34723111
Colitis	35.66	10.48	104	199276	37646	34719905
Dyspnoea	35.55	10.48	1772	197608	375010	34382541
Inadequate analgesia	35.31	10.48	62	199318	2913	34754638
Toxic epidermal necrolysis	35.12	10.48	43	199337	21603	34735948
Acute kidney injury	34.95	10.48	1404	197976	303584	34453967
Paraesthesia	34.55	10.48	536	198844	63636	34693915
Antidepressant drug level above therapeutic	34.55	10.48	20	199360	226	34757325
Aortic valve stenosis	34.27	10.48	58	199322	2645	34754906
Sopor	33.71	10.48	148	199232	11988	34745563
Multiple organ dysfunction syndrome	33.67	10.48	277	199103	76289	34681262
Congenital multiplex arthrogryposis	33.42	10.48	13	199367	53	34757498
Accidental poisoning	33.30	10.48	31	199349	759	34756792
Cerebral haemorrhage	33.19	10.48	96	199284	34841	34722710
Pulmonary function test abnormal	33.09	10.48	56	199324	2554	34754997
Haematotoxicity	32.91	10.48	4	199376	8190	34749361
Gastrointestinal haemorrhage	32.87	10.48	334	199046	88143	34669408
Synovitis	32.45	10.48	20	199360	14046	34743505
Erectile dysfunction	32.26	10.48	215	199165	20422	34737129
Pneumonitis	32.24	10.48	93	199287	33785	34723766
Blood bilirubin increased	31.64	10.48	112	199268	38184	34719367
Nervousness	31.49	10.48	149	199231	12457	34745094
Jaundice	31.47	10.48	86	199294	31796	34725755
Asterixis	31.47	10.48	37	199343	1196	34756355
Proteinuria	31.35	10.48	36	199344	18606	34738945
Renal failure	31.23	10.48	540	198840	130017	34627534
Pleural effusion	31.05	10.48	306	199074	81240	34676311
Victim of child abuse	30.90	10.48	32	199348	895	34756656
Off label use	30.69	10.48	2022	197358	417502	34340049
Contraindicated product administered	30.50	10.48	47	199333	21434	34736117
Irritability	30.42	10.48	243	199137	24447	34733104
Sweat gland disorder	30.22	10.48	14	199366	95	34757456
Analgesic drug level above therapeutic	30.11	10.48	20	199360	293	34757258
Parasomnia	29.94	10.48	22	199358	382	34757169
Delirium	29.94	10.48	383	198997	43608	34713943
Lethargy	29.69	10.48	362	199018	40760	34716791
Hallucination, visual	29.42	10.48	188	199192	17603	34739948
Haematochezia	29.28	10.48	151	199229	46383	34711168
Transaminases increased	29.06	10.48	69	199311	26754	34730797
Graft versus host disease	28.92	10.48	12	199368	10557	34746994
Gait inability	28.76	10.48	210	199170	20548	34737003
Gamma-glutamyltransferase increased	28.74	10.48	79	199301	29152	34728399
Hyperaesthesia	28.66	10.48	74	199306	4556	34752995
Full blood count decreased	28.61	10.48	189	199191	17899	34739652
Akathisia	28.17	10.48	106	199274	8003	34749548
Pneumocystis jirovecii pneumonia	28.11	10.48	43	199337	19667	34737884
Product dose omission issue	27.99	10.48	887	198493	118824	34638727
Hypernatraemia	27.89	10.48	7	199373	8483	34749068
Back pain	27.85	10.48	900	198480	120889	34636662
Hypertonic bladder	27.72	10.48	43	199337	1821	34755730
Erythema	27.53	10.48	349	199031	88431	34669120
Adverse drug reaction	27.49	10.48	272	199108	29070	34728481
Muscle twitching	27.40	10.48	124	199256	10174	34747377
Pathogen resistance	27.21	10.48	10	199370	9472	34748079
Labelled drug-drug interaction medication error	27.19	10.48	27	199353	14912	34742639
Mood altered	27.05	10.48	112	199268	8840	34748711
Post transplant lymphoproliferative disorder	26.68	10.48	3	199377	6525	34751026
Blood lactate dehydrogenase increased	26.65	10.48	57	199323	22933	34734618
Disorientation	26.56	10.48	298	199082	32890	34724661
Suspected suicide	26.48	10.48	73	199307	4675	34752876
Acute myocardial infarction	26.12	10.48	189	199191	53530	34704021
Product used for unknown indication	25.93	10.48	30	199350	953	34756598
Diabetic neuropathy	25.90	10.48	67	199313	4130	34753421
Spinal operation	25.87	10.48	54	199326	2890	34754661
Nerve injury	25.83	10.48	60	199320	3455	34754096
Dyskinesia	25.68	10.48	217	199163	22196	34735355
Acute respiratory distress syndrome	25.67	10.48	70	199310	25899	34731652
Sciatica	25.54	10.48	84	199296	5930	34751621
Cardio-respiratory arrest	25.44	10.48	450	198930	54823	34702728
Circulatory collapse	25.37	10.48	51	199329	20987	34736564
Peripheral swelling	25.24	10.48	593	198787	75948	34681603
Delirium tremens	25.17	10.48	24	199356	606	34756945
Pulmonary alveolar haemorrhage	25.05	10.48	6	199374	7506	34750045
Epistaxis	25.03	10.48	212	199168	58039	34699512
Bradyphrenia	25.02	10.48	72	199308	4726	34752825
Coordination abnormal	24.98	10.48	98	199282	7546	34750005
Posterior reversible encephalopathy syndrome	24.62	10.48	13	199367	9941	34747610
Myocarditis	24.59	10.48	25	199355	13657	34743894
Stress	24.51	10.48	273	199107	30074	34727477
Urinary incontinence	24.49	10.48	188	199192	18686	34738865
Agranulocytosis	24.46	10.48	63	199317	23758	34733793
Atrial fibrillation	24.43	10.48	522	198858	121871	34635680
Drug tolerance	24.33	10.48	52	199328	2830	34754721
Hostility	24.27	10.48	27	199353	821	34756730
Monoparesis	24.19	10.48	46	199334	2300	34755251
Pancytopenia	23.91	10.48	390	198990	94767	34662784
Shock haemorrhagic	23.72	10.48	18	199362	11336	34746215
Cholangitis	23.56	10.48	10	199370	8679	34748872
Venoocclusive liver disease	23.54	10.48	8	199372	7958	34749593
Drug eruption	23.35	10.48	49	199331	19849	34737702
Tooth disorder	23.21	10.48	123	199257	10759	34746792
Anaphylactic reaction	23.15	10.48	100	199280	32201	34725350
Anger	23.11	10.48	131	199249	11753	34745798
Head titubation	23.10	10.48	19	199361	392	34757159
Prostate cancer	23.10	10.48	132	199248	39517	34718034
Rash maculo-papular	22.98	10.48	84	199296	28367	34729184
Phantom limb syndrome	22.89	10.48	16	199364	256	34757295
Blood creatine phosphokinase increased	22.70	10.48	156	199224	44701	34712850
Nephropathy toxic	22.62	10.48	23	199357	12565	34744986
Restless legs syndrome	22.54	10.48	101	199279	8253	34749298
Dry mouth	22.41	10.48	267	199113	29898	34727653
Sedation complication	22.36	10.48	38	199342	1739	34755812
Anorgasmia	22.34	10.48	26	199354	831	34756720
Acute myeloid leukaemia	22.28	10.48	44	199336	18226	34739325
Cerebral infarction	22.21	10.48	81	199299	27374	34730177
Agitation	22.20	10.48	455	198925	56944	34700607
Foetal exposure during pregnancy	22.12	10.48	127	199253	37974	34719577
Encephalopathy neonatal	22.01	10.48	9	199371	43	34757508
Angioedema	22.00	10.48	124	199256	37250	34720301
Epstein-Barr virus infection	21.96	10.48	8	199372	7620	34749931
Hepatic enzyme increased	21.76	10.48	132	199248	38948	34718603
Acute hepatic failure	21.75	10.48	29	199351	14045	34743506
Tumour lysis syndrome	21.75	10.48	40	199340	17019	34740532
Suicidal behaviour	21.52	10.48	34	199346	1463	34756088
Neonatal toxicity	21.51	10.48	8	199372	28	34757523
Hypoacusis	21.50	10.48	163	199217	16138	34741413
Inflammation	21.27	10.48	86	199294	28209	34729342
Prescribed overdose	21.12	10.48	118	199262	10529	34747022
Ventricular tachycardia	21.12	10.48	79	199301	26500	34731051
Alcoholism	21.12	10.48	50	199330	2915	34754636
Epidural lipomatosis	21.09	10.48	28	199352	1026	34756525
Drug screen negative	21.03	10.48	13	199367	167	34757384
Haemolysis	20.87	10.48	10	199370	8084	34749467
Intervertebral disc protrusion	20.87	10.48	112	199268	9844	34747707
Transplant rejection	20.72	10.48	17	199363	10294	34747257
Drug tolerance increased	20.68	10.48	19	199361	457	34757094
Ischaemic stroke	20.53	10.48	46	199334	18204	34739347
Thrombosis	20.52	10.48	403	198977	50055	34707496
Bradypnoea	20.47	10.48	48	199332	2781	34754770
Child abuse	20.44	10.48	18	199362	409	34757142
Pulmonary toxicity	20.32	10.48	5	199375	6142	34751409
Personality disorder	20.32	10.48	29	199351	1139	34756412
Personality change	20.25	10.48	70	199310	5069	34752482
Liver disorder	20.24	10.48	108	199272	32889	34724662
Nephrolithiasis	20.18	10.48	263	199117	30070	34727481
Chest X-ray abnormal	20.10	10.48	63	199317	4335	34753216
Obesity	20.02	10.48	134	199246	12744	34744807
Cough	19.40	10.48	681	198699	149459	34608092
Haemoglobin decreased	18.94	10.48	534	198846	120238	34637313
Mental impairment	18.91	10.48	112	199268	10210	34747341
Nephrotic syndrome	18.87	10.48	9	199371	7294	34750257
Conversion disorder	18.83	10.48	16	199364	346	34757205
Treatment failure	18.72	10.48	173	199207	46524	34711027
Tuberculosis	18.70	10.48	13	199367	8564	34748987
Lower respiratory tract infection	18.61	10.48	105	199275	31532	34726019
Hyperbilirubinaemia	18.51	10.48	43	199337	16800	34740751
Pneumothorax	18.47	10.48	52	199328	19040	34738511
Palmar-plantar erythrodysaesthesia syndrome	18.36	10.48	43	199337	16752	34740799
Impaired driving ability	18.32	10.48	44	199336	2589	34754962
Immune reconstitution inflammatory syndrome	18.15	10.48	14	199366	8745	34748806
Mucosal atrophy	18.08	10.48	9	199371	73	34757478
Brief psychotic disorder with marked stressors	18.08	10.48	13	199367	218	34757333
Allodynia	18.07	10.48	23	199357	808	34756743
Hypomagnesaemia	17.99	10.48	64	199316	21787	34735764
Cytomegalovirus viraemia	17.94	10.48	10	199370	7420	34750131
Lumbar radiculopathy	17.79	10.48	23	199357	821	34756730
Haematuria	17.77	10.48	191	199189	49875	34707676
Affective disorder	17.72	10.48	60	199320	4300	34753251
Dysphoria	17.69	10.48	40	199340	2262	34755289
Facial wasting	17.49	10.48	11	199369	146	34757405
Ear deformity acquired	17.43	10.48	5	199375	5	34757546
Neoplasm progression	17.40	10.48	71	199309	23229	34734322
Distributive shock	17.37	10.48	28	199352	1226	34756325
Osteomyelitis	17.32	10.48	154	199226	15982	34741569
Opisthotonus	17.17	10.48	17	199363	450	34757101
Aggression	17.14	10.48	315	199065	38649	34718902
Quality of life decreased	17.10	10.48	56	199324	3945	34753606
Blood pressure fluctuation	16.99	10.48	80	199300	25169	34732382
Hepatotoxicity	16.98	10.48	64	199316	21421	34736130
Violence-related symptom	16.97	10.48	18	199362	518	34757033
Localised infection	16.94	10.48	164	199216	17423	34740128
Cytokine release syndrome	16.90	10.48	70	199310	22807	34734744
Bladder cancer	16.75	10.48	43	199337	16235	34741316
Idiopathic neutropenia	16.69	10.48	4	199376	0	34757551
Precancerous skin lesion	16.63	10.48	19	199361	595	34756956
Rectal haemorrhage	16.61	10.48	148	199232	40101	34717450
Cerebral disorder	16.55	10.48	42	199338	2559	34754992
Hepatitis	16.52	10.48	75	199305	23829	34733722
Road traffic accident	16.46	10.48	162	199218	17288	34740263
Intentional product use issue	16.43	10.48	241	199139	59575	34697976
Panic attack	16.42	10.48	101	199279	9331	34748220
Sleep disorder	16.41	10.48	263	199117	31425	34726126
Cognitive disorder	16.34	10.48	242	199138	28451	34729100
Amphetamines positive	16.30	10.48	12	199368	209	34757342
Heat exhaustion	16.28	10.48	11	199369	166	34757385
Stiff person syndrome	16.23	10.48	9	199371	93	34757458
Autoimmune haemolytic anaemia	16.21	10.48	3	199377	4493	34753058
Acute coronary syndrome	16.19	10.48	33	199347	13512	34744039
Binocular eye movement disorder	16.17	10.48	8	199372	64	34757487
Left ventricular dysfunction	16.11	10.48	20	199360	9987	34747564
Hyperthyroidism	16.10	10.48	22	199358	10544	34747007
Therapeutic response unexpected	16.07	10.48	103	199277	9654	34747897
Hypoalbuminaemia	16.01	10.48	28	199352	12146	34745405
Encephalitis	15.90	10.48	11	199369	7266	34750285
Mucormycosis	15.85	10.48	7	199373	5935	34751616
Breakthrough pain	15.83	10.48	18	199362	561	34756990
Hypersomnia	15.77	10.48	123	199257	12284	34745267
Acute graft versus host disease in skin	15.76	10.48	5	199375	5196	34752355
Degenerative bone disease	15.76	10.48	8	199372	68	34757483
Metastases to liver	15.73	10.48	34	199346	13629	34743922
Muscular weakness	15.70	10.48	535	198845	72362	34685189
Hyperhidrosis	15.67	10.48	553	198827	75139	34682412
Thinking abnormal	15.66	10.48	73	199307	6064	34751487
Metabolic encephalopathy	15.66	10.48	57	199323	4235	34753316
Blood creatinine increased	15.64	10.48	417	198963	94559	34662992
Oesophageal carcinoma	15.61	10.48	18	199362	9286	34748265
Drug use disorder	15.58	10.48	56	199324	4135	34753416
Loss of proprioception	15.53	10.48	15	199365	385	34757166
Seizure	15.49	10.48	739	198641	104118	34653433
Lung disorder	15.48	10.48	125	199255	34571	34722980
Pulmonary tuberculosis	15.46	10.48	4	199376	4750	34752801
Migraine	15.40	10.48	160	199220	17318	34740233
Gingival atrophy	15.30	10.48	7	199373	46	34757505
Blood pressure systolic increased	15.28	10.48	73	199307	22879	34734672
Spinal stenosis	15.20	10.48	65	199315	5204	34752347
Myasthenia gravis	15.18	10.48	79	199301	6861	34750690
Stomatitis	15.16	10.48	162	199218	42352	34715199
Central nervous system lesion	15.14	10.48	75	199305	6388	34751163
Diastolic dysfunction	15.11	10.48	73	199307	6154	34751397
Foetal disorder	15.10	10.48	21	199359	805	34756746
Stevens-Johnson syndrome	15.07	10.48	55	199325	18584	34738967
Leukaemia	15.03	10.48	59	199321	4544	34753007
Back injury	15.03	10.48	54	199326	3987	34753564
Haemorrhage intracranial	15.01	10.48	44	199336	15902	34741649
Anaphylactic shock	14.99	10.48	44	199336	15897	34741654
Feeding intolerance	14.97	10.48	10	199370	148	34757403
Inflammatory marker increased	14.95	10.48	5	199375	5023	34752528
Dysphemia	14.90	10.48	30	199350	1565	34755986
Acute pulmonary oedema	14.88	10.48	12	199368	7331	34750220
Peritonitis	14.80	10.48	46	199334	16319	34741232
Radiculopathy	14.76	10.48	42	199338	2739	34754812
Oxygen saturation decreased	14.72	10.48	217	199163	53601	34703950
Muscle tightness	14.67	10.48	61	199319	4823	34752728
Oesophageal mucosa erythema	14.62	10.48	6	199374	29	34757522
Hepatocellular injury	14.58	10.48	71	199309	22140	34735411
Colitis ulcerative	14.54	10.48	47	199333	16473	34741078
Tubulointerstitial nephritis	14.51	10.48	66	199314	20958	34736593
Hypometabolism	14.34	10.48	9	199371	119	34757432
Feeling drunk	14.32	10.48	33	199347	1890	34755661
Schizophrenia	14.29	10.48	17	199363	8649	34748902
Tachycardia	14.27	10.48	371	199009	84401	34673150
Respiratory disorder	14.19	10.48	59	199321	19205	34738346
Cardiac failure acute	14.19	10.48	24	199356	10546	34747005
Artery dissection	14.15	10.48	9	199371	122	34757429
Ventricular hypokinesia	14.10	10.48	7	199373	5545	34752006
Rhabdomyolysis	14.09	10.48	289	199091	67874	34689677
Drug abuser	14.00	10.48	52	199328	3902	34753649
Fear of weight gain	13.94	10.48	4	199376	4	34757547
Alcohol withdrawal syndrome	13.94	10.48	28	199352	1458	34756093
Anal abscess	13.86	10.48	10	199370	6463	34751088
Candida infection	13.85	10.48	53	199327	17662	34739889
Musculoskeletal disorder	13.83	10.48	71	199309	6133	34751418
Fibromyalgia	13.80	10.48	44	199336	3056	34754495
Adrenal insufficiency	13.78	10.48	38	199342	14009	34743542
Intentional underdose	13.76	10.48	18	199362	650	34756901
Oropharyngeal oedema	13.70	10.48	8	199372	92	34757459
Large intestine perforation	13.68	10.48	17	199363	8486	34749065
Blood phosphorus increased	13.65	10.48	83	199297	7638	34749913
Cardiac arrest	13.63	10.48	675	198705	95484	34662067
Fungal infection	13.57	10.48	46	199334	15889	34741662
Enterococcal infection	13.56	10.48	20	199360	9286	34748265
Abnormal labour affecting foetus	13.55	10.48	5	199375	17	34757534
Second primary malignancy	13.51	10.48	15	199365	7871	34749680
Hypertriglyceridaemia	13.48	10.48	17	199363	8431	34749120
Nocturia	13.41	10.48	102	199278	10108	34747443
Haemorrhage	13.41	10.48	209	199171	51161	34706390
Micturition urgency	13.40	10.48	73	199307	6452	34751099
Toxic skin eruption	13.39	10.48	28	199352	11357	34746194
Neurogenic bladder	13.38	10.48	31	199349	1782	34755769
Graft versus host disease in skin	13.36	10.48	3	199377	3922	34753629
Gastrointestinal adenocarcinoma	13.35	10.48	7	199373	64	34757487
Tracheobronchitis bacterial	13.33	10.48	5	199375	18	34757533
Ejection fraction decreased	13.30	10.48	60	199320	19094	34738457
Product communication issue	13.28	10.48	14	199366	400	34757151
Uveitis	13.28	10.48	14	199366	7521	34750030
Body height decreased	13.16	10.48	50	199330	3793	34753758
Drug withdrawal syndrome neonatal	13.15	10.48	48	199332	3571	34753980
Polyneuropathy in malignant disease	13.09	10.48	11	199369	234	34757317
Abnormal sleep-related event	13.08	10.48	15	199365	472	34757079
Immature granulocyte percentage increased	13.06	10.48	4	199376	6	34757545
Enthesopathy	13.01	10.48	5	199375	4608	34752943
Hypotension	12.97	10.48	1088	198292	220561	34536990
Neutrophil count increased	12.96	10.48	52	199328	17094	34740457
Neutropenic sepsis	12.95	10.48	38	199342	13729	34743822
Free androgen index decreased	12.93	10.48	5	199375	20	34757531
Slow speech	12.93	10.48	24	199356	1178	34756373
Sleep attacks	12.93	10.48	9	199371	143	34757408
Bipolar I disorder	12.90	10.48	19	199361	768	34756783
Hypertransaminasaemia	12.89	10.48	8	199372	5598	34751953
Blood urea increased	12.82	10.48	111	199269	30253	34727298
Implant site inflammation	12.79	10.48	8	199372	105	34757446
Rales	12.75	10.48	23	199357	9860	34747691
Hepatitis fulminant	12.75	10.48	4	199376	4186	34753365
Rheumatoid arthritis	12.73	10.48	148	199232	38090	34719461
Blood alkaline phosphatase increased	12.71	10.48	115	199265	31060	34726491
Gastric cancer	12.59	10.48	11	199369	6458	34751093
Electric shock	12.56	10.48	9	199371	150	34757401
Pulmonary fibrosis	12.55	10.48	58	199322	18338	34739213
Cholestasis	12.53	10.48	96	199284	26852	34730699
Traumatic amputation	12.52	10.48	3	199377	0	34757551
Nasal odour	12.52	10.48	3	199377	0	34757551
Severe myoclonic epilepsy of infancy	12.52	10.48	3	199377	0	34757551
Benign neoplasm of spinal cord	12.52	10.48	3	199377	0	34757551
Pancreatic fibrosis	12.52	10.48	3	199377	0	34757551
Opiates positive	12.51	10.48	16	199364	565	34756986
Pneumonia bacterial	12.50	10.48	31	199349	11841	34745710
Abnormal behaviour	12.47	10.48	206	199174	24763	34732788
Dependence	12.42	10.48	23	199357	1127	34756424
Swelling	12.39	10.48	323	199057	42043	34715508
Systemic candida	12.38	10.48	3	199377	3723	34753828
Nerve compression	12.35	10.48	44	199336	3235	34754316
Foot fracture	12.35	10.48	59	199321	4952	34752599
Cardiogenic shock	12.34	10.48	217	199163	26401	34731150
Open angle glaucoma	12.31	10.48	9	199371	155	34757396
Rib fracture	12.30	10.48	131	199249	14269	34743282
Lymphocyte count decreased	12.29	10.48	77	199303	22545	34735006
Cellulitis	12.26	10.48	392	198988	52559	34704992
Major depression	12.13	10.48	55	199325	4517	34753034
Diarrhoea	12.12	10.48	1997	197383	387915	34369636
Herpes zoster	12.10	10.48	269	199111	34130	34723421
Retinal haemorrhage	12.07	10.48	7	199373	5082	34752469
Nephrogenic systemic fibrosis	12.01	10.48	50	199330	3955	34753596
Chronic graft versus host disease	11.91	10.48	5	199375	4368	34753183
Neck surgery	11.82	10.48	13	199367	390	34757161
Pseudomonas infection	11.77	10.48	34	199346	12348	34745203
Teeth brittle	11.72	10.48	6	199374	52	34757499
Asphyxia	11.71	10.48	13	199367	6822	34750729
Movement disorder	11.69	10.48	114	199266	12134	34745417
Application site hypersensitivity	11.61	10.48	8	199372	125	34757426
Electrocardiogram QT prolonged	11.59	10.48	164	199216	40788	34716763
Intervertebral disc injury	11.59	10.48	5	199375	28	34757523
Sensory loss	11.58	10.48	55	199325	4604	34752947
Infective pulmonary exacerbation of cystic fibrosis	11.58	10.48	13	199367	6788	34750763
Joint hyperextension	11.44	10.48	8	199372	128	34757423
Complications of transplanted kidney	11.43	10.48	6	199374	4603	34752948
Adenovirus infection	11.42	10.48	8	199372	5249	34752302
Neutropenia neonatal	11.40	10.48	17	199363	695	34756856
Arrhythmia	11.38	10.48	140	199240	35668	34721883
Multiple-drug resistance	11.34	10.48	8	199372	5231	34752320
Trigeminal neuralgia	11.34	10.48	23	199357	1206	34756345
Systemic infection	11.23	10.48	8	199372	5204	34752347
White blood cell count increased	11.23	10.48	166	199214	40985	34716566
Post laminectomy syndrome	11.18	10.48	9	199371	180	34757371
Polyarthritis	11.12	10.48	6	199374	4534	34753017
Mouth ulceration	11.11	10.48	33	199347	11877	34745674
Carcinogenicity	11.08	10.48	6	199374	59	34757492
Thoracic vertebral fracture	11.07	10.48	28	199352	1702	34755849
Malaise	11.04	10.48	911	198469	184914	34572637
Hyperuricaemia	11.04	10.48	18	199362	8025	34749526
Developmental hip dysplasia	11.03	10.48	11	199369	294	34757257
Mental disorder	11.02	10.48	134	199246	15075	34742476
Decreased interest	10.97	10.48	34	199346	2326	34755225
Immunosuppressant drug level increased	10.95	10.48	11	199369	6044	34751507
Hypogammaglobulinaemia	10.93	10.48	17	199363	7723	34749828
Intestinal perforation	10.89	10.48	22	199358	9038	34748513
Platelet count decreased	10.84	10.48	565	198815	119152	34638399
Surgery	10.82	10.48	126	199254	14031	34743520
Seborrhoeic keratosis	10.81	10.48	23	199357	1248	34756303
Peripheral vascular disorder	10.79	10.48	57	199323	4979	34752572
Blood pressure decreased	10.77	10.48	218	199162	51297	34706254
Cyanosis	10.76	10.48	37	199343	12727	34744824
Hypotony maculopathy	10.75	10.48	4	199376	14	34757537
Multiple cardiac defects	10.74	10.48	6	199374	63	34757488
Arteriospasm coronary	10.71	10.48	3	199377	3379	34754172
Incision site complication	10.70	10.48	11	199369	305	34757246
Postmortem blood drug level	10.69	10.48	9	199371	192	34757359
Colorectal cancer	10.67	10.48	7	199373	4754	34752797
Electrocardiogram abnormal	10.66	10.48	23	199357	9224	34748327
Hypocalcaemia	10.61	10.48	88	199292	24201	34733350
Lipodystrophy acquired	10.52	10.48	3	199377	3341	34754210
Hyperglycaemia	10.51	10.48	160	199220	39320	34718231
Narcolepsy	10.50	10.48	14	199366	515	34757036
Spinal fusion surgery	10.50	10.48	20	199360	1001	34756550
Myocardial infarction	10.49	10.48	574	198806	120511	34637040

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug hypersensitivity	2540.28	9.73	5353	443473	293563	79001999
Completed suicide	1640.48	9.73	4002	444824	241765	79053797
Drug ineffective for unapproved indication	1265.07	9.73	1501	447325	49737	79245825
Toxicity to various agents	622.37	9.73	4281	444545	417259	78878303
Myoclonus	579.00	9.73	746	448080	26914	79268648
Somnolence	522.92	9.73	2692	446134	236289	79059273
Pemphigus	510.55	9.73	10	448816	99572	79195990
Multiple sclerosis relapse	465.94	9.73	894	447932	45639	79249923
Drug abuse	427.36	9.73	1932	446894	160759	79134803
Synovitis	410.47	9.73	167	448659	150567	79144995
Hand deformity	384.05	9.73	62	448764	103857	79191705
Fall	377.52	9.73	4299	444527	483330	78812232
Pericarditis	363.93	9.73	72	448754	104164	79191398
Glossodynia	335.35	9.73	84	448742	103253	79192309
Duodenal ulcer perforation	330.29	9.73	9	448817	66202	79229360
Systemic lupus erythematosus	318.96	9.73	141	448685	121008	79174554
Depression	315.72	9.73	2196	446630	214594	79080968
Contraindicated product administered	314.33	9.73	255	448571	157283	79138279
Maternal exposure during pregnancy	309.18	9.73	193	448633	136345	79159217
Rheumatoid factor positive	288.27	9.73	11	448815	59828	79235734
Helicobacter infection	282.78	9.73	31	448795	69673	79225889
Drug withdrawal syndrome	266.46	9.73	598	448228	34120	79261442
Hepatic enzyme increased	260.32	9.73	390	448436	182220	79113342
Drug dependence	258.55	9.73	652	448174	40117	79255445
Respiratory arrest	253.85	9.73	807	448019	56743	79238819
Tremor	251.14	9.73	1729	447097	168354	79127208
Infusion related reaction	243.77	9.73	588	448238	229649	79065913
Arthropathy	238.45	9.73	393	448433	176718	79118844
Multiple sclerosis	234.05	9.73	437	448389	21845	79273717
Mental status changes	228.32	9.73	862	447964	66097	79229465
Withdrawal syndrome	219.03	9.73	474	448352	26380	79269182
Accidental death	215.85	9.73	185	448641	4106	79291456
Interstitial lung disease	215.09	9.73	190	448636	112410	79183152
C-reactive protein increased	214.17	9.73	246	448580	128781	79166781
General physical health deterioration	211.29	9.73	815	448011	274423	79021139
Feeling abnormal	205.97	9.73	1568	447258	157631	79137931
Suicidal ideation	205.08	9.73	913	447913	75427	79220135
Febrile neutropenia	200.69	9.73	649	448177	230350	79065212
Dizziness	196.73	9.73	4102	444724	522339	78773223
Muscle injury	195.96	9.73	22	448804	48539	79247023
Memory impairment	195.00	9.73	1185	447641	110549	79185013
Hallucination	192.13	9.73	973	447853	84772	79210790
Sedation	191.14	9.73	685	448141	51210	79244352
Joint swelling	188.34	9.73	909	447917	287737	79007825
Pyrexia	183.81	9.73	2702	446124	676007	78619555
Sleep disorder due to general medical condition, insomnia type	182.84	9.73	17	448809	43539	79252023
Folliculitis	181.63	9.73	44	448782	55336	79240226
Confusional state	162.15	9.73	2602	446224	315395	78980167
Wound	160.83	9.73	253	448573	115926	79179636
Respiratory depression	159.89	9.73	427	448399	27203	79268359
Cardio-respiratory arrest	154.73	9.73	1094	447732	107416	79188146
Hepatic function abnormal	152.53	9.73	113	448713	72994	79222568
Muscle spasms	151.06	9.73	1576	447250	173154	79122408
Exposure during pregnancy	150.95	9.73	209	448617	100923	79194639
Cytomegalovirus infection	147.68	9.73	30	448796	42614	79252948
Discomfort	147.46	9.73	303	448523	125314	79170248
Balance disorder	147.03	9.73	1007	447819	97850	79197712
Anxiety	145.41	9.73	2082	446744	246430	79049132
Vision blurred	144.82	9.73	1057	447769	104841	79190721
Hypersensitivity	144.40	9.73	874	447952	261365	79034197
C-reactive protein abnormal	142.73	9.73	47	448779	48320	79247242
Pain in extremity	142.38	9.73	2860	445966	361678	78933884
Neuralgia	138.05	9.73	458	448368	32926	79262636
Therapeutic product effect decreased	137.02	9.73	468	448358	163395	79132167
Gait disturbance	135.47	9.73	1773	447053	205733	79089829
Lower respiratory tract infection	129.69	9.73	339	448487	128881	79166681
Product dose omission issue	129.32	9.73	2034	446792	245503	79050059
Sopor	128.68	9.73	444	448382	32566	79262996
Anaemia	125.36	9.73	1757	447069	443258	78852304
Myelosuppression	119.18	9.73	39	448787	40257	79255305
Overdose	116.93	9.73	1566	447260	182640	79112922
Intentional product misuse	116.73	9.73	926	447900	94239	79201323
Cardiac failure	113.95	9.73	466	448360	154376	79141186
Hypoaesthesia	111.89	9.73	1520	447306	177832	79117730
Swollen joint count increased	111.16	9.73	4	448822	22923	79272639
Irritable bowel syndrome	110.66	9.73	112	448714	62129	79233433
Thrombocytopenia	106.28	9.73	967	447859	264292	79031270
Neuropathy peripheral	106.26	9.73	1240	447586	140065	79155497
Mucosal inflammation	101.38	9.73	168	448658	75412	79220150
Impaired healing	100.70	9.73	214	448612	87441	79208121
Nightmare	99.20	9.73	346	448480	25515	79270047
Lethargy	99.14	9.73	790	448036	80502	79215060
Insomnia	97.10	9.73	1928	446898	243242	79052320
Rheumatic fever	96.85	9.73	21	448805	28504	79267058
Drug resistance	95.05	9.73	60	448766	42153	79253409
Cardiac arrest	92.06	9.73	1420	447406	170676	79124886
Neutropenia	90.04	9.73	1111	447715	286599	79008963
Drug use disorder	90.01	9.73	169	448657	8482	79287080
Sleep apnoea syndrome	88.13	9.73	423	448403	36055	79259507
Migraine	87.16	9.73	813	448013	86680	79208882
Inadequate analgesia	86.31	9.73	118	448708	4511	79291051
Bone marrow failure	85.25	9.73	97	448729	51010	79244552
Depressed level of consciousness	84.05	9.73	873	447953	95779	79199783
Liver injury	82.48	9.73	119	448707	56495	79239067
Plasma cell myeloma	82.44	9.73	548	448278	52711	79242851
Urinary tract infection	81.12	9.73	2071	446755	272441	79023121
Product complaint	81.00	9.73	210	448616	13139	79282423
Abdominal discomfort	78.89	9.73	967	447859	249760	79045802
Ataxia	77.72	9.73	313	448513	24726	79270836
Dysarthria	76.98	9.73	647	448179	66975	79228587
Serotonin syndrome	76.27	9.73	474	448352	44553	79251009
Dyskinesia	75.01	9.73	470	448356	44303	79251259
Mood altered	74.81	9.73	246	448580	17601	79277961
Burning sensation	74.35	9.73	575	448251	58057	79237505
Hallucination, visual	73.70	9.73	372	448454	32357	79263205
Intervertebral disc degeneration	72.94	9.73	225	448601	15560	79280002
Pancytopenia	72.69	9.73	590	448236	165155	79130407
Malignant neoplasm progression	72.31	9.73	458	448368	135532	79160030
Death	71.41	9.73	3884	444942	562630	78732932
Suspected suicide	71.11	9.73	173	448653	10403	79285159
Haemophagocytic lymphohistiocytosis	68.45	9.73	19	448807	21818	79273744
Euphoric mood	68.36	9.73	141	448685	7585	79287977
Ill-defined disorder	68.25	9.73	170	448656	65705	79229857
Intentional product use issue	67.85	9.73	539	448287	151573	79143989
Right atrial hypertrophy	66.94	9.73	46	448780	725	79294837
Crying	66.76	9.73	282	448544	22761	79272801
Muscle twitching	66.34	9.73	296	448530	24468	79271094
Unresponsive to stimuli	66.30	9.73	539	448287	55249	79240313
Seizure	65.93	9.73	1458	447368	187376	79108186
Alopecia	65.88	9.73	911	447915	230444	79065118
Mental disorder	65.10	9.73	348	448478	30954	79264608
Hyperaesthesia	64.86	9.73	183	448643	12039	79283523
Nervousness	64.47	9.73	364	448462	33051	79262511
Drug reaction with eosinophilia and systemic symptoms	63.33	9.73	170	448656	64074	79231488
Fatigue	62.37	9.73	6056	442770	923671	78371891
Hypokalaemia	62.13	9.73	515	448311	143525	79152037
Device expulsion	62.13	9.73	34	448792	25827	79269735
Back disorder	62.07	9.73	174	448652	11404	79284158
Appendicolith	61.96	9.73	144	448682	8407	79287155
Multiple organ dysfunction syndrome	61.88	9.73	409	448417	119837	79175725
Spinal operation	61.44	9.73	137	448689	7780	79287782
Bone erosion	60.88	9.73	13	448813	17834	79277728
Therapeutic response unexpected	60.85	9.73	248	448578	19698	79275864
Head injury	60.57	9.73	389	448437	36980	79258582
Infection	60.47	9.73	976	447850	240736	79054826
Treatment failure	60.47	9.73	640	448186	169846	79125716
Amnesia	59.85	9.73	580	448246	62477	79233085
Blister	59.67	9.73	410	448416	119066	79176496
Septic shock	59.08	9.73	426	448400	122375	79173187
Blood lactate dehydrogenase increased	58.38	9.73	81	448745	39089	79256473
Swelling	58.30	9.73	863	447963	215848	79079714
Irritability	58.13	9.73	414	448412	40730	79254832
Melaena	57.87	9.73	164	448662	60726	79234836
Intervertebral disc protrusion	57.85	9.73	275	448551	23346	79272216
Live birth	57.47	9.73	17	448809	18727	79276835
Coordination abnormal	57.44	9.73	221	448605	17091	79278471
Speech disorder	57.30	9.73	512	448314	53933	79241629
Pneumocystis jirovecii pneumonia	57.21	9.73	59	448767	32449	79263113
Urinary incontinence	56.85	9.73	410	448416	40499	79255063
Anticipatory anxiety	56.71	9.73	50	448776	1154	79294408
Back pain	56.66	9.73	2170	446656	302010	78993552
Paraesthesia	56.45	9.73	1345	447481	174978	79120584
Pleural effusion	55.79	9.73	535	448291	144727	79150835
Accidental poisoning	55.51	9.73	57	448769	1600	79293962
Rash	55.46	9.73	2675	446151	575683	78719879
Stomatitis	55.31	9.73	543	448283	146214	79149348
Hepatic failure	54.47	9.73	170	448656	61042	79234520
Atrial fibrillation	54.28	9.73	785	448041	197101	79098461
Muscular weakness	53.58	9.73	1233	447593	159496	79136066
Eosinophilia	53.51	9.73	109	448717	45236	79250326
Stiff person syndrome	53.22	9.73	29	448797	293	79295269
Bradyphrenia	52.30	9.73	155	448671	10485	79285077
Colitis	51.81	9.73	224	448602	73083	79222479
Agitation	51.47	9.73	818	448008	98897	79196665
Feeling drunk	51.37	9.73	94	448732	4625	79290937
Hepatotoxicity	51.28	9.73	135	448691	51217	79244345
Disseminated intravascular coagulation	50.59	9.73	77	448749	35765	79259797
Renal impairment	50.18	9.73	607	448219	157176	79138386
Drug intolerance	50.16	9.73	1118	447708	263001	79032561
Presbyacusis	49.88	9.73	68	448758	2592	79292970
Anger	49.69	9.73	210	448616	16952	79278610
Rash maculo-papular	49.02	9.73	157	448669	55921	79239641
Rheumatoid arthritis	48.16	9.73	854	447972	207616	79087946
Nasopharyngitis	47.83	9.73	1076	447750	252805	79042757
Restless legs syndrome	47.10	9.73	231	448595	19861	79275701
Hypersomnia	46.88	9.73	255	448571	22831	79272731
Post transplant lymphoproliferative disorder	46.74	9.73	5	448821	11459	79284103
Psoriatic arthropathy	46.61	9.73	253	448573	77746	79217816
Transaminases increased	46.54	9.73	143	448683	51600	79243962
Anaphylactic shock	46.44	9.73	82	448744	35914	79259648
Rheumatoid nodule	46.34	9.73	20	448806	17418	79278144
Asterixis	46.00	9.73	66	448760	2641	79292921
Poisoning	45.95	9.73	271	448555	25001	79270561
Toxic epidermal necrolysis	45.44	9.73	116	448710	44465	79251097
Acute graft versus host disease	45.38	9.73	3	448823	10164	79285398
Gait spastic	45.31	9.73	44	448782	1153	79294409
Constipation	45.29	9.73	1987	446839	281063	79014499
Aspergillus infection	44.86	9.73	26	448800	19135	79276427
Jaundice	44.81	9.73	152	448674	53197	79242365
Trigeminal neuralgia	44.60	9.73	76	448750	3533	79292029
Agranulocytosis	44.50	9.73	119	448707	44911	79250651
Osteonecrosis of jaw	44.42	9.73	112	448714	43114	79252448
Red blood cell sedimentation rate abnormal	44.24	9.73	32	448794	20931	79274631
Alanine aminotransferase increased	44.19	9.73	646	448180	161924	79133638
Myocardial stunning	44.01	9.73	22	448804	183	79295379
Right ventricular hypertrophy	43.78	9.73	50	448776	1587	79293975
Graft versus host disease	43.63	9.73	15	448811	15011	79280551
Off label use	43.60	9.73	4457	444369	902758	78392804
Anorgasmia	43.58	9.73	44	448782	1210	79294352
Therapeutic response decreased	43.25	9.73	211	448615	66642	79228920
Transplant rejection	43.25	9.73	28	448798	19409	79276153
Hyperhidrosis	42.68	9.73	1136	447690	150356	79145206
Hyperreflexia	42.03	9.73	123	448703	8262	79287300
Disorientation	42.00	9.73	539	448287	62237	79233325
Pulmonary fibrosis	41.78	9.73	119	448707	43993	79251569
Blood bilirubin increased	41.72	9.73	211	448615	66021	79229541
Accidental overdose	41.54	9.73	372	448454	39209	79256353
Impaired driving ability	41.23	9.73	93	448733	5322	79290240
Diplopia	41.21	9.73	326	448500	33140	79262422
Pleural thickening	41.16	9.73	66	448760	2916	79292646
Myokymia	41.06	9.73	18	448808	107	79295455
Leukopenia	41.05	9.73	438	448388	116075	79179487
Neutrophil count decreased	40.93	9.73	335	448491	93624	79201938
Haematotoxicity	40.92	9.73	18	448808	15501	79280061
Vertigo	40.81	9.73	580	448246	68502	79227060
Pleural fibrosis	40.40	9.73	79	448747	4088	79291474
Proteinuria	40.19	9.73	76	448750	32426	79263136
Relapsing-remitting multiple sclerosis	39.96	9.73	46	448780	1473	79294089
Premature delivery	39.72	9.73	44	448782	23423	79272139
Hip arthroplasty	39.65	9.73	89	448737	35667	79259895
Joint injury	39.55	9.73	307	448519	31028	79264534
Delirium	39.53	9.73	683	448143	83944	79211618
Venoocclusive liver disease	39.29	9.73	9	448817	11762	79283800
Erythema	39.09	9.73	957	447869	222333	79073229
Acute respiratory distress syndrome	38.78	9.73	123	448703	43944	79251618
Drug-induced liver injury	38.66	9.73	216	448610	65901	79229661
Cytomegalovirus viraemia	38.64	9.73	12	448814	12809	79282753
Bronchopulmonary aspergillosis	38.63	9.73	41	448785	22253	79273309
Surgery	38.62	9.73	316	448510	32450	79263112
Thrombotic microangiopathy	38.53	9.73	34	448792	20135	79275427
Nausea	37.70	9.73	6033	442793	951163	78344399
Cytomegalovirus infection reactivation	37.68	9.73	3	448823	8713	79286849
Needle fatigue	37.65	9.73	35	448791	867	79294695
Lymphoedema	37.59	9.73	154	448672	12259	79283303
Somatic symptom disorder	37.58	9.73	58	448768	2479	79293083
Sinusitis	37.54	9.73	826	448000	194675	79100887
Neck pain	37.54	9.73	615	448211	74802	79220760
Full blood count decreased	37.39	9.73	269	448557	26550	79269012
Gastrointestinal disorder	36.65	9.73	476	448350	121729	79173833
Acute myeloid leukaemia	36.64	9.73	74	448752	30811	79264751
Epistaxis	36.21	9.73	427	448399	111088	79184474
Ankle fracture	36.20	9.73	190	448636	16779	79278783
Influenza like illness	36.16	9.73	586	448240	71121	79224441
Mental impairment	35.82	9.73	206	448620	18830	79276732
Knee arthroplasty	35.79	9.73	124	448702	43124	79252438
Shock haemorrhagic	35.76	9.73	36	448790	20024	79275538
Therapeutic product effect variable	35.64	9.73	50	448776	1959	79293603
Pulmonary toxicity	35.63	9.73	14	448812	12900	79282662
Headache	35.48	9.73	4200	444626	649572	78645990
Chorea	35.44	9.73	55	448771	2362	79293200
Stress	35.22	9.73	637	448189	78975	79216587
Muscle tightness	35.07	9.73	155	448671	12759	79282803
Neovascularisation	34.96	9.73	39	448787	1206	79294356
Visual snow syndrome	34.80	9.73	13	448813	47	79295515
Pregnancy	34.79	9.73	61	448765	26790	79268772
Disturbance in attention	34.75	9.73	438	448388	50363	79245199
Injection site mass	34.50	9.73	213	448613	19971	79275591
Hostility	34.48	9.73	53	448773	2257	79293305
Prescription drug used without a prescription	34.33	9.73	73	448753	4012	79291550
Somatic delusion	34.18	9.73	30	448796	688	79294874
Diabetic neuropathy	33.90	9.73	94	448732	6122	79289440
Complex regional pain syndrome	33.44	9.73	49	448777	1999	79293563
Blood magnesium increased	33.42	9.73	66	448760	3440	79292122
Erectile dysfunction	33.24	9.73	167	448659	14497	79281065
Panniculitis	33.17	9.73	14	448812	12357	79283205
Epstein-Barr virus infection	33.13	9.73	20	448806	14396	79281166
Alcoholism	33.00	9.73	68	448758	3655	79291907
Hypermobility syndrome	32.76	9.73	26	448800	516	79295046
Cystitis haemorrhagic	32.71	9.73	6	448820	9166	79286396
Obsessive-compulsive disorder	32.69	9.73	90	448736	5837	79289725
Coma	32.57	9.73	769	448057	99880	79195682
Arthralgia	32.41	9.73	2774	446052	569029	78726533
Tumour lysis syndrome	32.29	9.73	53	448773	23886	79271676
Central nervous system lesion	32.27	9.73	155	448671	13213	79282349
Pain	32.26	9.73	4475	444351	699327	78596235
Encephalopathy	32.22	9.73	546	448280	66851	79228711
Dysstasia	31.85	9.73	266	448560	27480	79268082
Muscle spasticity	31.45	9.73	218	448608	21257	79274305
Toxic skin eruption	31.36	9.73	48	448778	22245	79273317
Posterior reversible encephalopathy syndrome	31.15	9.73	63	448763	26218	79269344
Neutropenic sepsis	31.13	9.73	66	448760	26998	79268564
Appendicitis	31.00	9.73	212	448614	20582	79274980
Paranoia	30.70	9.73	201	448625	19231	79276331
Disease progression	30.68	9.73	796	448030	183566	79111996
Blood cholesterol increased	30.60	9.73	312	448514	83408	79212154
Bronchial wall thickening	30.53	9.73	54	448772	2587	79292975
Victim of child abuse	30.52	9.73	32	448794	921	79294641
Incoherent	30.44	9.73	104	448722	7588	79287974
Panic attack	30.42	9.73	237	448589	23979	79271583
Cholangitis	30.39	9.73	17	448809	12759	79282803
Product use issue	30.31	9.73	924	447902	208898	79086664
Limb injury	30.21	9.73	276	448550	29252	79266310
Gastrointestinal haemorrhage	30.14	9.73	618	448208	147101	79148461
Pathogen resistance	30.13	9.73	22	448804	14320	79281242
Drug abuser	29.94	9.73	88	448738	5925	79289637
Cerebral infarction	29.64	9.73	144	448682	45532	79250030
Hypertonic bladder	29.62	9.73	70	448756	4131	79291431
Nerve injury	29.62	9.73	118	448708	9274	79286288
Drug screen positive	29.49	9.73	88	448738	5975	79289587
Myocarditis	29.43	9.73	48	448778	21685	79273877
Inflammation	29.29	9.73	362	448464	93391	79202171
Thinking abnormal	29.21	9.73	149	448677	13012	79282550
Lung disorder	29.12	9.73	301	448525	80256	79215306
Metastases to liver	28.60	9.73	74	448752	28240	79267322
Pulmonary tuberculosis	28.36	9.73	5	448821	7860	79287702
Dry mouth	28.32	9.73	672	448154	87347	79208215
Drug eruption	28.22	9.73	139	448687	43796	79251766
Dysphemia	27.84	9.73	61	448765	3423	79292139
Haemolysis	27.77	9.73	19	448807	12793	79282769
Cerebral haemorrhage	27.76	9.73	200	448626	57473	79238089
Allodynia	27.74	9.73	40	448786	1608	79293954
Pituitary tumour benign	27.65	9.73	51	448775	2525	79293037
Gamma-glutamyltransferase increased	27.61	9.73	187	448639	54493	79241069
Therapy non-responder	27.50	9.73	360	448466	91945	79203617
Therapy cessation	27.49	9.73	328	448498	37234	79258328
Labelled drug-drug interaction medication error	27.37	9.73	73	448753	27577	79267985
Cytokine release syndrome	27.31	9.73	107	448719	35891	79259671
Autonomic nervous system imbalance	27.24	9.73	72	448754	4558	79291004
Acute kidney injury	27.19	9.73	2535	446291	516869	78778693
Drug tolerance decreased	27.14	9.73	20	448806	12958	79282604
Cellulitis	27.13	9.73	805	448021	108255	79187307
Epidural lipomatosis	27.08	9.73	34	448792	1194	79294368
Hepatocellular injury	27.01	9.73	157	448669	47436	79248126
Pneumonitis	26.96	9.73	216	448610	60644	79234918
Lupus-like syndrome	26.91	9.73	23	448803	13834	79281728
Device adhesion issue	26.63	9.73	4	448822	7071	79288491
Gait inability	26.61	9.73	473	448353	58444	79237118
Micturition urgency	26.60	9.73	141	448685	12500	79283062
Blood parathyroid hormone decreased	26.57	9.73	13	448813	10523	79285039
Metabolic encephalopathy	26.54	9.73	112	448714	9035	79286527
Adjustment disorder with depressed mood	26.51	9.73	9	448817	9077	79286485
Skin necrosis	26.36	9.73	38	448788	18049	79277513
Pulmonary function test abnormal	25.98	9.73	66	448760	4078	79291484
Nerve compression	25.94	9.73	112	448714	9127	79286435
Bradypnoea	25.89	9.73	84	448742	5968	79289594
Tooth loss	25.71	9.73	93	448733	6982	79288580
Burns second degree	25.69	9.73	50	448776	2578	79292984
Hyperbilirubinaemia	25.60	9.73	63	448763	24455	79271107
Spinal osteoarthritis	25.48	9.73	173	448653	16754	79278808
Hip fracture	25.39	9.73	275	448551	30486	79265076
Graft versus host disease in gastrointestinal tract	25.34	9.73	3	448823	6353	79289209
Antipsychotic drug level below therapeutic	25.29	9.73	33	448793	1205	79294357
Focal dyscognitive seizures	25.29	9.73	59	448767	3453	79292109
Rib deformity	25.27	9.73	16	448810	218	79295344
Tuberculosis	25.17	9.73	29	448797	15169	79280393
Transplant dysfunction	25.17	9.73	5	448821	7216	79288346
Prostate cancer	25.16	9.73	99	448727	33169	79262393
Tardive dyskinesia	25.11	9.73	122	448704	10449	79285113
Device difficult to use	25.05	9.73	23	448803	13362	79282200
Haemoglobin decreased	24.98	9.73	1009	447817	221110	79074452
Bone density decreased	24.90	9.73	23	448803	13324	79282238
Dyspnoea	24.83	9.73	4345	444481	852680	78442882
Acute coronary syndrome	24.76	9.73	51	448775	21082	79274480
Type 2 diabetes mellitus	24.72	9.73	204	448622	56918	79238644
Cardiac failure acute	24.53	9.73	43	448783	18886	79276676
Pre-existing condition improved	24.51	9.73	78	448748	5485	79290077
Loss of consciousness	24.25	9.73	1167	447659	166776	79128786
Slow speech	24.05	9.73	47	448779	2431	79293131
Pollakiuria	23.95	9.73	318	448508	36999	79258563
Haematochezia	23.90	9.73	348	448478	87297	79208265
Parasomnia	23.87	9.73	22	448804	539	79295023
Breast cancer stage II	23.76	9.73	8	448818	8112	79287450
Bipolar disorder	23.64	9.73	96	448730	7611	79287951
Hypercholesterolaemia	23.61	9.73	60	448766	23035	79272527
Concussion	23.53	9.73	111	448715	9392	79286170
Acute graft versus host disease in skin	23.38	9.73	7	448819	7651	79287911
Foot fracture	23.27	9.73	207	448619	21774	79273788
Limb discomfort	23.23	9.73	285	448541	32565	79262997
Exposure via ingestion	23.21	9.73	73	448753	5101	79290461
Pseudomonas infection	23.20	9.73	52	448774	20851	79274711
Epigastric discomfort	23.16	9.73	97	448729	7799	79287763
Cognitive disorder	23.15	9.73	536	448290	69390	79226172
Quality of life decreased	23.15	9.73	118	448708	10302	79285260
Complications of transplanted kidney	23.06	9.73	4	448822	6362	79289200
Blood creatine phosphokinase increased	23.05	9.73	249	448577	65841	79229721
Chronic graft versus host disease	23.00	9.73	5	448821	6776	79288786
Tinnitus	22.99	9.73	364	448462	43969	79251593
Schizophrenia	22.94	9.73	32	448794	15408	79280154
Liver disorder	22.85	9.73	279	448547	72138	79223424
Rales	22.82	9.73	49	448777	19952	79275610
Peritonitis	22.79	9.73	81	448745	27955	79267607
Hepatitis	22.78	9.73	202	448624	55525	79240037
Conversion disorder	22.75	9.73	39	448787	1822	79293740
Acute myocardial infarction	22.75	9.73	301	448525	76735	79218827
Diffuse axonal injury	22.74	9.73	12	448814	113	79295449
Oesophageal spasm	22.67	9.73	56	448770	3400	79292162
Circulatory collapse	22.60	9.73	122	448704	37546	79258016
Device use error	22.59	9.73	6	448820	7095	79288467
Acute hepatic failure	22.53	9.73	90	448736	30023	79265539
Analgesic drug level above therapeutic	22.42	9.73	20	448806	469	79295093
Cyst	22.38	9.73	144	448682	13696	79281866
Dysphoria	22.36	9.73	68	448758	4666	79290896
Alanine aminotransferase abnormal	22.27	9.73	11	448815	8856	79286706
Decreased interest	22.27	9.73	58	448768	3639	79291923
Oesophageal carcinoma	22.01	9.73	18	448808	11066	79284496
Tubulointerstitial nephritis	21.76	9.73	126	448700	38109	79257453
Angioedema	21.76	9.73	299	448527	75736	79219826
Blood pressure systolic abnormal	21.61	9.73	40	448786	17207	79278355
Skin toxicity	21.36	9.73	10	448816	8304	79287258
Colorectal cancer	21.31	9.73	11	448815	8636	79286926
Cholestasis	21.25	9.73	189	448637	51920	79243642
Dependence	21.19	9.73	44	448782	2378	79293184
Ischaemic stroke	21.18	9.73	105	448721	33026	79262536
Product used for unknown indication	21.07	9.73	34	448792	1510	79294052
Hypomagnesaemia	21.00	9.73	166	448660	46745	79248817
Gastric cancer	20.88	9.73	16	448810	10163	79285399
Rib fracture	20.87	9.73	245	448581	27702	79267860
Phantom limb syndrome	20.86	9.73	17	448809	351	79295211
Red blood cell sedimentation rate increased	20.84	9.73	162	448664	45780	79249782
Blood pressure systolic increased	20.79	9.73	259	448567	66727	79228835
Congenital multiplex arthrogryposis	20.77	9.73	7	448819	17	79295545
Stevens-Johnson syndrome	20.76	9.73	132	448694	39034	79256528
Ejection fraction decreased	20.74	9.73	112	448714	34465	79261097
Spinal stenosis	20.65	9.73	156	448670	15635	79279927
Obstruction	20.64	9.73	65	448761	4545	79291017
Gestational diabetes	20.63	9.73	5	448821	6288	79289274
Palmar-plantar erythrodysaesthesia syndrome	20.61	9.73	106	448720	33028	79262534
Child abuse	20.57	9.73	18	448808	411	79295151
Condition aggravated	20.54	9.73	2488	446338	498636	78796926
Deafness neurosensory	20.43	9.73	85	448741	6813	79288749
Antidepressant drug level above therapeutic	20.41	9.73	22	448804	654	79294908
Skin reaction	20.37	9.73	37	448789	16031	79279531
Disorganised speech	20.36	9.73	40	448786	2077	79293485
Unintentional medical device removal	20.25	9.73	9	448817	7703	79287859
Uveitis	20.24	9.73	40	448786	16790	79278772
Premature labour	20.20	9.73	11	448815	8379	79287183
Breakthrough pain	20.03	9.73	31	448795	1328	79294234
Persistent depressive disorder	19.92	9.73	29	448797	1176	79294386
Aspartate aminotransferase increased	19.90	9.73	611	448215	138030	79157532
Abnormal dreams	19.87	9.73	121	448705	11291	79284271
Psychotic disorder due to a general medical condition	19.86	9.73	15	448811	276	79295286
Hepatitis fulminant	19.83	9.73	8	448818	7254	79288308
Sweat gland disorder	19.76	9.73	13	448813	190	79295372
Sensory disturbance	19.75	9.73	149	448677	14928	79280634
Depressed mood	19.74	9.73	383	448443	48097	79247465
Dermatitis exfoliative generalised	19.73	9.73	8	448818	7233	79288329
Sacroiliitis	19.71	9.73	56	448770	3698	79291864
Creatinine renal clearance decreased	19.71	9.73	49	448777	18953	79276609
Duodenal ulcer	19.61	9.73	39	448787	16330	79279232
Psychomotor hyperactivity	19.59	9.73	162	448664	16687	79278875
Subileus	19.53	9.73	4	448822	5650	79289912
Neurogenic bladder	19.42	9.73	60	448766	4152	79291410
Developmental hip dysplasia	19.41	9.73	13	448813	196	79295366
Granuloma skin	19.36	9.73	14	448812	9160	79286402
Disinhibition	19.10	9.73	44	448782	2554	79293008
Violence-related symptom	19.00	9.73	22	448804	709	79294853
Bladder cancer	18.99	9.73	52	448774	19474	79276088
Herpes zoster	18.98	9.73	671	448155	92412	79203150
Breast cancer stage I	18.92	9.73	7	448819	6693	79288869
Cough	18.90	9.73	1792	447034	364997	78930565
Abnormal behaviour	18.87	9.73	299	448527	36122	79259440
Nephrotic syndrome	18.86	9.73	21	448805	11153	79284409
Delirium tremens	18.83	9.73	22	448804	716	79294846
Autoimmune haemolytic anaemia	18.74	9.73	12	448814	8368	79287194
Asthenia	18.68	9.73	3213	445613	508476	78787086
Intentional self-injury	18.67	9.73	271	448555	32148	79263414
Nephropathy toxic	18.67	9.73	56	448770	20363	79275199
Abortion spontaneous	18.58	9.73	94	448732	29413	79266149
Pruritus	18.42	9.73	1942	446884	392706	78902856
X-ray abnormal	18.33	9.73	5	448821	5808	79289754
Lip dry	18.24	9.73	37	448789	15381	79280181
Somnambulism	18.14	9.73	72	448754	5649	79289913
Secondary progressive multiple sclerosis	18.04	9.73	30	448796	1367	79294195
Enterocolitis	17.88	9.73	34	448792	14478	79281084
Haematuria	17.84	9.73	276	448550	68560	79227002
Drug effective for unapproved indication	17.82	9.73	74	448752	5927	79289635
Osteosclerosis	17.79	9.73	56	448770	3915	79291647
Graft versus host disease in skin	17.74	9.73	6	448820	6067	79289495
Respiratory disorder	17.72	9.73	164	448662	44692	79250870
Vascular malformation	17.70	9.73	16	448810	382	79295180
Pneumonia bacterial	17.69	9.73	53	448773	19278	79276284
Endophthalmitis	17.68	9.73	7	448819	6421	79289141
Aggression	17.61	9.73	393	448433	50565	79244997
Anal abscess	17.60	9.73	16	448810	9339	79286223
Thrombosis	17.58	9.73	608	448218	83492	79212070
Body height decreased	17.57	9.73	95	448731	8485	79287077
Renal failure	17.55	9.73	938	447888	200030	79095532
Wheezing	17.52	9.73	511	448315	116153	79179409
Hyperthyroidism	17.50	9.73	65	448761	22144	79273418
Ear deformity acquired	17.49	9.73	5	448821	5	79295557
Blood pressure fluctuation	17.48	9.73	269	448557	66876	79228686
Haemorrhage	17.47	9.73	385	448441	90733	79204829
Polyarthritis	17.43	9.73	26	448800	12176	79283386
Micrognathia	17.41	9.73	6	448820	16	79295546
Visual impairment	17.29	9.73	658	448168	91473	79204089
Inflammatory marker increased	17.25	9.73	21	448805	10719	79284843
Hypertension	17.21	9.73	1616	447210	329376	78966186
Long QT syndrome	17.20	9.73	6	448820	5949	79289613
Jaundice cholestatic	17.15	9.73	23	448803	11261	79284301
Lumbar radiculopathy	17.12	9.73	36	448790	1963	79293599
Blood pressure increased	17.09	9.73	994	447832	210366	79085196
Injury	17.08	9.73	320	448506	77176	79218386
Hyperuricaemia	16.99	9.73	25	448801	11774	79283788
Product physical issue	16.93	9.73	57	448769	4128	79291434
Brain injury	16.92	9.73	117	448709	11400	79284162
Snoring	16.81	9.73	69	448757	5497	79290065
Nephrogenic systemic fibrosis	16.78	9.73	74	448752	6086	79289476
Idiopathic neutropenia	16.74	9.73	4	448822	0	79295562
Hyperacusis	16.73	9.73	38	448788	2185	79293377
Asphyxia	16.71	9.73	25	448801	11695	79283867
Chest X-ray abnormal	16.63	9.73	88	448738	7795	79287767
Metabolic acidosis	16.61	9.73	346	448480	82183	79213379
Arteriovenous malformation	16.61	9.73	33	448793	1728	79293834
Binocular eye movement disorder	16.60	9.73	10	448816	124	79295438
Eosinophilic colitis	16.56	9.73	17	448809	477	79295085
Chronic sinusitis	16.51	9.73	30	448796	12996	79282566
Ligament sprain	16.49	9.73	131	448695	13333	79282229
Fluid retention	16.48	9.73	512	448314	69297	79226265
Sports injury	16.47	9.73	11	448815	165	79295397
Hypothyroidism	16.47	9.73	202	448624	52190	79243372
Urticaria	16.44	9.73	863	447963	184338	79111224
Adenovirus infection	16.43	9.73	14	448812	8433	79287129
Injection site induration	16.40	9.73	103	448723	9716	79285846
Drug diversion	16.35	9.73	27	448799	1223	79294339
Autoimmune disorder	16.34	9.73	44	448782	16568	79278994
Immunosuppressant drug level increased	16.32	9.73	16	448810	9011	79286551
Colitis microscopic	16.31	9.73	22	448804	10746	79284816
Fear of injection	16.31	9.73	11	448815	7463	79288099
Cervical spinal stenosis	16.30	9.73	39	448787	2320	79293242
Affective disorder	16.29	9.73	91	448735	8228	79287334
Drug tolerance increased	16.27	9.73	19	448807	618	79294944
Facial spasm	16.24	9.73	21	448805	760	79294802
Facial pain	16.15	9.73	122	448704	12228	79283334
Neutropenic colitis	16.06	9.73	6	448820	5701	79289861
Increased appetite	16.04	9.73	119	448707	11859	79283703
Urinary retention	16.03	9.73	425	448401	56205	79239357
Aphasia	16.02	9.73	360	448466	46372	79249190
Cystitis	15.88	9.73	399	448427	52333	79243229
Pre-eclampsia	15.86	9.73	10	448816	7031	79288531
Respiratory rate decreased	15.84	9.73	65	448761	5178	79290384
Pericardial effusion	15.80	9.73	175	448651	46062	79249500
Deprescribing error	15.79	9.73	6	448820	23	79295539
Movement disorder	15.75	9.73	228	448598	27031	79268531
Pallor	15.75	9.73	193	448633	49869	79245693
Platelet count decreased	15.64	9.73	916	447910	193748	79101814
Hypoxic-ischaemic encephalopathy	15.62	9.73	86	448740	7734	79287828
Rectal haemorrhage	15.62	9.73	319	448507	75981	79219581
Myelodysplastic syndrome	15.61	9.73	103	448723	30198	79265364
Laboratory test abnormal	15.58	9.73	233	448593	27815	79267747
Hypokinesia	15.55	9.73	170	448656	18890	79276672
Tendonitis	15.53	9.73	75	448751	23755	79271807
Eyelid myoclonus	15.48	9.73	9	448817	104	79295458
Kidney transplant rejection	15.46	9.73	21	448805	10225	79285337
Tenosynovitis	15.44	9.73	41	448785	15513	79280049
Joint destruction	15.42	9.73	7	448819	5918	79289644
Mouth ulceration	15.33	9.73	140	448686	38254	79257308
Mucormycosis	15.33	9.73	15	448811	8454	79287108
Head banging	15.28	9.73	17	448809	524	79295038
Hypopnoea	15.27	9.73	65	448761	5264	79290298
Monoparesis	15.26	9.73	49	448777	3462	79292100
Product communication issue	15.22	9.73	24	448802	1045	79294517
Myoclonic epilepsy	15.19	9.73	34	448792	1936	79293626
Sensory loss	15.15	9.73	125	448701	12866	79282696
Arthrofibrosis	15.12	9.73	9	448817	109	79295453
Lactic acidosis	15.05	9.73	292	448534	70067	79225495
Tachyphrenia	15.04	9.73	35	448791	2045	79293517
Organising pneumonia	14.96	9.73	24	448802	10915	79284647
Spinal disorder	14.94	9.73	104	448722	10156	79285406
Brief psychotic disorder with marked stressors	14.89	9.73	13	448813	296	79295266
Congenital neuropathy	14.88	9.73	5	448821	12	79295550
Pulmonary alveolar haemorrhage	14.87	9.73	26	448800	11431	79284131
Atonic urinary bladder	14.84	9.73	8	448818	79	79295483
Cytomegalovirus colitis	14.83	9.73	4	448822	4681	79290881
Drug screen negative	14.78	9.73	13	448813	299	79295263
Alcohol withdrawal syndrome	14.72	9.73	34	448792	1977	79293585
Systemic infection	14.70	9.73	20	448806	9732	79285830
Teeth brittle	14.62	9.73	16	448810	484	79295078
Human herpesvirus 6 infection	14.52	9.73	6	448820	5364	79290198
Acute pulmonary oedema	14.52	9.73	37	448789	14193	79281369
Systemic candida	14.46	9.73	10	448816	6696	79288866
Hypernatraemia	14.42	9.73	38	448788	14413	79281149
Radiation necrosis	14.35	9.73	15	448811	430	79295132
Anal incontinence	14.34	9.73	161	448665	18007	79277555
Oropharyngeal oedema	14.33	9.73	15	448811	431	79295131
Post laminectomy syndrome	14.29	9.73	13	448813	313	79295249
Self-medication	14.24	9.73	62	448764	5070	79290492
Lip oedema	14.19	9.73	9	448817	6307	79289255
Postmortem blood drug level increased	14.15	9.73	20	448806	789	79294773
Decreased appetite	14.14	9.73	1699	447127	340719	78954843
Hypercalcaemia	14.13	9.73	143	448683	38287	79257275
Abnormal sleep-related event	14.13	9.73	21	448805	868	79294694
Paranasal cyst	14.08	9.73	15	448811	440	79295122
Rapid eye movements sleep abnormal	13.97	9.73	12	448814	267	79295295
Musculoskeletal stiffness	13.97	9.73	824	448002	174184	79121378
Febrile bone marrow aplasia	13.96	9.73	33	448793	12987	79282575
Gastrointestinal toxicity	13.95	9.73	15	448811	8094	79287468
Mobility decreased	13.94	9.73	554	448272	121621	79173941
Acute generalised exanthematous pustulosis	13.92	9.73	50	448776	17204	79278358
Stress cardiomyopathy	13.90	9.73	26	448800	11140	79284422
Hot flush	13.90	9.73	406	448420	54471	79241091
JC polyomavirus test positive	13.90	9.73	29	448797	1573	79293989
Blood pressure decreased	13.87	9.73	440	448386	99026	79196536
Product use in unapproved indication	13.87	9.73	1611	447215	248748	79046814
Encephalitis	13.84	9.73	40	448786	14720	79280842
Hypometabolism	13.83	9.73	9	448817	129	79295433
Face oedema	13.82	9.73	97	448729	28039	79267523
Cardiac failure chronic	13.80	9.73	26	448800	11109	79284453
Colitis ulcerative	13.73	9.73	127	448699	34615	79260947
Haemolytic uraemic syndrome	13.70	9.73	4	448822	4445	79291117
Acute graft versus host disease in intestine	13.67	9.73	3	448823	4038	79291524
Varicella zoster virus infection	13.67	9.73	4	448822	4437	79291125
Clonus	13.52	9.73	75	448751	6765	79288797
Gout	13.52	9.73	205	448621	24544	79271018
Urine amphetamine positive	13.51	9.73	8	448818	96	79295466
Atrioventricular block complete	13.49	9.73	48	448778	16562	79279000
Formication	13.42	9.73	60	448766	4963	79290599
Opisthotonus	13.37	9.73	18	448808	678	79294884
Myofascial pain syndrome	13.35	9.73	33	448793	2004	79293558
Substance use	13.34	9.73	21	448805	913	79294649
Hypoalbuminaemia	13.32	9.73	68	448758	21229	79274333
Tachycardia	13.31	9.73	842	447984	176926	79118636
Lumbar spinal stenosis	13.30	9.73	62	448764	5220	79290342
Bronchial secretion retention	13.30	9.73	52	448774	4052	79291510
Large intestine perforation	13.28	9.73	40	448786	14527	79281035
Osteopenia	13.28	9.73	160	448666	18204	79277358
Parosmia	13.26	9.73	76	448750	6938	79288624
Caesarean section	13.25	9.73	32	448794	12503	79283059
Stillbirth	13.25	9.73	3	448823	3952	79291610
Hypoacusis	13.24	9.73	241	448585	29909	79265653
Aortic valve stenosis	13.23	9.73	62	448764	5232	79290330
Bone cyst	13.22	9.73	46	448780	3387	79292175
Cerebral disorder	13.22	9.73	64	448762	5474	79290088
Osteomyelitis	13.16	9.73	259	448567	32606	79262956
Dry eye	13.14	9.73	286	448540	36645	79258917
Peroneal nerve palsy	13.13	9.73	68	448758	5974	79289588
Breath sounds abnormal	13.11	9.73	46	448780	15938	79279624
Spinal cord injury	13.10	9.73	25	448801	1270	79294292
Nocturia	13.05	9.73	126	448700	13555	79282007
Erythema multiforme	13.05	9.73	53	448773	17598	79277964
Accidental exposure to product	13.04	9.73	113	448713	31209	79264353
Eyelid oedema	12.90	9.73	37	448789	13650	79281912
Oesophageal pain	12.89	9.73	53	448773	4226	79291336
Generalised tonic-clonic seizure	12.85	9.73	331	448495	43579	79251983
Carpal tunnel syndrome	12.78	9.73	167	448659	19361	79276201
Liver function test abnormal	12.77	9.73	271	448555	64204	79231358
Disturbance in social behaviour	12.74	9.73	6	448820	4964	79290598
Myopathy	12.67	9.73	66	448760	20497	79275065
Cytomegalovirus test positive	12.65	9.73	9	448817	5938	79289624
Liver function test increased	12.64	9.73	153	448673	39620	79255942
Lymphoproliferative disorder	12.61	9.73	8	448818	5607	79289955
Diffuse large B-cell lymphoma recurrent	12.57	9.73	4	448822	4203	79291359
Basal cell carcinoma	12.56	9.73	142	448684	37233	79258329
CSF neutrophil count increased	12.56	9.73	3	448823	0	79295562
Blood potassium	12.56	9.73	3	448823	0	79295562
Turbinectomy	12.56	9.73	3	448823	0	79295562
Tinel's sign	12.56	9.73	3	448823	0	79295562
Ligamentum flavum hypertrophy	12.56	9.73	3	448823	0	79295562
Muscle relaxant drug level above therapeutic	12.56	9.73	3	448823	0	79295562
Ulcer	12.53	9.73	108	448718	29864	79265698
Femoral artery dissection	12.53	9.73	6	448820	45	79295517
Haemorrhage intracranial	12.52	9.73	91	448735	26102	79269460
Toe operation	12.52	9.73	16	448810	572	79294990
Abortion induced	12.40	9.73	13	448813	7096	79288466
Prophylaxis	12.39	9.73	4	448822	8	79295554
Gingival atrophy	12.34	9.73	7	448819	77	79295485
Anosognosia	12.32	9.73	3	448823	3761	79291801
Feeling of body temperature change	12.32	9.73	61	448765	5265	79290297
Haematoma	12.30	9.73	213	448613	51982	79243580
Toxicologic test abnormal	12.24	9.73	25	448801	1335	79294227
Bladder disorder	12.24	9.73	91	448735	9074	79286488
Cytopenia	12.24	9.73	66	448760	20317	79275245
Cerebrovascular accident	12.21	9.73	1024	447802	154268	79141294
Immune-mediated enterocolitis	12.12	9.73	6	448820	4824	79290738
Concomitant disease aggravated	12.12	9.73	36	448790	13131	79282431
Carotid artery disease	12.11	9.73	34	448792	2230	79293332
Metastases to bone	12.10	9.73	84	448742	24343	79271219
Cytomegalovirus chorioretinitis	12.09	9.73	8	448818	5482	79290080
Vertebral foraminal stenosis	12.09	9.73	23	448803	1166	79294396
Vascular stent thrombosis	12.06	9.73	3	448823	3707	79291855
Intercepted medication error	12.06	9.73	20	448806	909	79294653
Left ventricular dysfunction	12.01	9.73	62	448764	19299	79276263
Narcolepsy	12.01	9.73	24	448802	1262	79294300
Product adhesion issue	11.99	9.73	38	448788	2666	79292896
Pneumatosis intestinalis	11.96	9.73	11	448815	6386	79289176
Drug screen false positive	11.96	9.73	22	448804	1087	79294475
Drug level below therapeutic	11.94	9.73	23	448803	9747	79285815
Infective pulmonary exacerbation of cystic fibrosis	11.93	9.73	35	448791	12816	79282746
Gastrointestinal inflammation	11.85	9.73	15	448811	7529	79288033
Shock	11.84	9.73	173	448653	43375	79252187
Naevus haemorrhage	11.81	9.73	8	448818	123	79295439
Pregnancy with contraceptive device	11.79	9.73	3	448823	3651	79291911
Blood potassium decreased	11.75	9.73	344	448482	46168	79249394
Progressive multiple sclerosis	11.71	9.73	23	448803	1194	79294368
Subarachnoid haemorrhage	11.70	9.73	85	448741	24380	79271182
Polyneuropathy in malignant disease	11.69	9.73	11	448815	277	79295285
Dermatitis bullous	11.68	9.73	41	448785	14204	79281358
Disability	11.68	9.73	53	448773	17067	79278495
Band sensation	11.65	9.73	18	448808	770	79294792
Metastases to peritoneum	11.64	9.73	5	448821	4367	79291195
Musculoskeletal chest pain	11.61	9.73	200	448626	24564	79270998
Hypertensive urgency	11.60	9.73	15	448811	543	79295019
Bronchospasm	11.58	9.73	87	448739	24772	79270790
Scleritis	11.57	9.73	5	448821	4351	79291211
Nerve block	11.56	9.73	17	448809	696	79294866
Pharyngitis	11.56	9.73	76	448750	22299	79273263
Granuloma	11.54	9.73	18	448808	8279	79287283
Visual field tests abnormal	11.52	9.73	4	448822	11	79295551
Heteroplasia	11.52	9.73	4	448822	11	79295551
Blood potassium increased	11.49	9.73	230	448596	29045	79266517
Dissociation	11.48	9.73	49	448777	3972	79291590
Bone contusion	11.47	9.73	23	448803	1212	79294350
Oral herpes	11.45	9.73	99	448727	27355	79268207
Radiculopathy	11.44	9.73	87	448739	8737	79286825
Lipodystrophy acquired	11.43	9.73	5	448821	4320	79291242
Ejaculation delayed	11.41	9.73	9	448817	177	79295385
Respiratory tract infection	11.37	9.73	199	448627	48490	79247072
Vulvar basal cell carcinoma	11.37	9.73	5	448821	30	79295532
Lymphoma	11.35	9.73	55	448771	17405	79278157
Diffuse large B-cell lymphoma	11.34	9.73	33	448793	12116	79283446
Sciatic nerve injury	11.32	9.73	15	448811	556	79295006
Second primary malignancy	11.31	9.73	42	448784	14308	79281254
Radiation pneumonitis	11.29	9.73	4	448822	3929	79291633
Intentional underdose	11.29	9.73	34	448792	2320	79293242
Application site vesicles	11.27	9.73	25	448801	1415	79294147
Retinal haemorrhage	11.26	9.73	18	448808	8199	79287363
Myotonia	11.26	9.73	10	448816	233	79295329
Neuropathic arthropathy	11.23	9.73	12	448814	353	79295209
Atrioventricular block	11.12	9.73	41	448785	14000	79281562
Gait apraxia	11.10	9.73	5	448821	32	79295530
Substance abuse	11.08	9.73	99	448727	10427	79285135
Nasal polyps	11.07	9.73	15	448811	7312	79288250
Essential hypertension	11.06	9.73	65	448761	5988	79289574
Immune effector cell-associated neurotoxicity syndrome	11.00	9.73	10	448816	5838	79289724
Medication overuse headache	11.00	9.73	19	448807	893	79294669
Libido decreased	10.96	9.73	59	448767	5262	79290300
Skin plaque	10.92	9.73	28	448798	10717	79284845
Bacteraemia	10.92	9.73	125	448701	32699	79262863
Adrenal insufficiency	10.89	9.73	105	448721	28382	79267180
Breast disorder	10.89	9.73	31	448795	2050	79293512
Arrhythmia	10.87	9.73	262	448564	61010	79234552
Open angle glaucoma	10.87	9.73	13	448813	434	79295128
Nystagmus	10.86	9.73	94	448732	9810	79285752
Intra-abdominal haemorrhage	10.86	9.73	6	448820	4534	79291028
Tendon injury	10.85	9.73	31	448795	2054	79293508
Muscle contractions involuntary	10.85	9.73	46	448780	3719	79291843
Pneumonia fungal	10.79	9.73	30	448796	11180	79284382
Lymphadenopathy	10.78	9.73	223	448603	53024	79242538
Subdural haematoma	10.73	9.73	119	448707	31315	79264247
Protein C deficiency	10.73	9.73	5	448821	35	79295527
Leg amputation	10.72	9.73	45	448781	3621	79291941
Injection site reaction	10.69	9.73	393	448433	54392	79241170
Hepatitis acute	10.67	9.73	48	448778	15494	79280068
Mitral valve prolapse	10.65	9.73	31	448795	2076	79293486
Nitrite urine present	10.62	9.73	22	448804	1187	79294375
Lung adenocarcinoma stage I	10.61	9.73	5	448821	36	79295526
Free androgen index decreased	10.59	9.73	4	448822	15	79295547
Panic disorder	10.59	9.73	39	448787	2953	79292609
Pustular psoriasis	10.59	9.73	7	448819	4799	79290763
Blood potassium abnormal	10.56	9.73	40	448786	3070	79292492
Paradoxical drug reaction	10.56	9.73	73	448753	7112	79288450
Screaming	10.53	9.73	47	448779	3886	79291676
Retinal deposits	10.51	9.73	8	448818	149	79295413
Acute myeloid leukaemia recurrent	10.50	9.73	3	448823	3380	79292182
Peritoneal carcinoma metastatic	10.49	9.73	3	448823	3	79295559
Sleep disorder due to a general medical condition	10.47	9.73	43	448783	14234	79281328
Grip strength decreased	10.45	9.73	76	448750	21793	79273769
Neck surgery	10.41	9.73	28	448798	1791	79293771
Suicidal behaviour	10.41	9.73	41	448785	3206	79292356
Neuromyelitis optica spectrum disorder	10.40	9.73	20	448806	1022	79294540
CD8 lymphocytes decreased	10.39	9.73	10	448816	259	79295303
International normalised ratio increased	10.36	9.73	381	448445	84340	79211222
Ascites	10.35	9.73	335	448491	75227	79220335
Glycosylated haemoglobin decreased	10.33	9.73	16	448810	686	79294876
Hospice care	10.31	9.73	96	448730	10228	79285334
Genital haemorrhage	10.29	9.73	12	448814	6243	79289319
Intervertebral disc disorder	10.28	9.73	54	448772	4771	79290791
Crepitations	10.26	9.73	26	448800	9991	79285571
Application site burn	10.26	9.73	18	448808	857	79294705
Blood phosphorus increased	10.22	9.73	96	448730	10251	79285311
Pineal gland cyst	10.21	9.73	4	448822	17	79295545
Feeling of despair	10.18	9.73	37	448789	2784	79292778
Bradycardia	10.16	9.73	642	448184	134915	79160647
Infected skin ulcer	10.15	9.73	42	448784	3359	79292203
Upper respiratory tract inflammation	10.14	9.73	5	448821	4030	79291532
Hypocalcaemia	10.13	9.73	209	448617	49715	79245847
Implant site inflammation	10.11	9.73	10	448816	268	79295294
Amphetamines positive	10.10	9.73	11	448815	331	79295231
Renal tubular disorder	10.08	9.73	13	448813	6473	79289089
Camptodactyly congenital	10.04	9.73	3	448823	4	79295558
Benign neoplasm of spinal cord	10.04	9.73	3	448823	4	79295558
Sleep paralysis	10.04	9.73	15	448811	623	79294939
Alcohol interaction	10.01	9.73	54	448772	4820	79290742
Pulmonary renal syndrome	10	9.73	15	448811	625	79294937
Post herpetic neuralgia	9.99	9.73	35	448791	2586	79292976
Hepatitis cholestatic	9.99	9.73	42	448784	13810	79281752
Post procedural infection	9.97	9.73	103	448723	11281	79284281
Face injury	9.97	9.73	44	448782	3620	79291942
Cortisol abnormal	9.92	9.73	6	448820	75	79295487
Heat exhaustion	9.92	9.73	11	448815	338	79295224
Gastrointestinal necrosis	9.91	9.73	10	448816	5555	79290007
Transplant failure	9.90	9.73	7	448819	4634	79290928
Drug tolerance	9.87	9.73	83	448743	8592	79286970
Abnormal weight gain	9.82	9.73	35	448791	2609	79292953
Nail disorder	9.79	9.73	34	448792	11818	79283744
Blood thyroid stimulating hormone normal	9.79	9.73	7	448819	118	79295444
Accident	9.78	9.73	84	448742	8747	79286815
Thyroiditis	9.76	9.73	7	448819	4598	79290964
Medical induction of coma	9.74	9.73	7	448819	119	79295443

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Trismus	42.20	24.61	17	323	129	89323

Pharmacologic Action:

Source	Code	Description
ATC	N02BF01	NERVOUS SYSTEM ANALGESICS OTHER ANALGESICS AND ANTIPYRETICS Gabapentinoids
FDA PE	N0000008486	Decreased Central Nervous System Disorganized Electrical Activity
MeSH PA	D000700	Analgesics
MeSH PA	D014151	Anti-Anxiety Agents
MeSH PA	D000927	Anticonvulsants
MeSH PA	D018692	Antimanic Agents
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D002492	Central Nervous System Depressants
MeSH PA	D018691	Excitatory Amino Acid Antagonists
MeSH PA	D018377	Neurotransmitter Agents
MeSH PA	D018373	Peripheral Nervous System Agents
MeSH PA	D011619	Psychotropic Drugs
MeSH PA	D018689	Sensory System Agents
MeSH PA	D014149	Tranquilizing Agents
FDA EPC	N0000175753	Anti-epileptic Agent
CHEBI has role	CHEBI:35623	anticonvulsants
CHEBI has role	CHEBI:35703	Xenobiotic
CHEBI has role	CHEBI:38215	calcium channel blockers
CHEBI has role	CHEBI:78298	environmental contaminants

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Postherpetic neuralgia	indication	2177002
Restless legs	indication	32914008	DOID:0050425
Partial Epilepsy Treatment Adjunct	indication
Alcohol use disorder	off-label use	7200002
Menopausal night sweats	off-label use	42984000
Chronic cough	off-label use	68154008
Chronic pain	off-label use	82423001
Insomnia	off-label use	193462001
Anxiety disorder	off-label use	197480006	DOID:2030
Menopausal flushing	off-label use	198436008
Fibromyalgia	off-label use	203082005	DOID:631
Neuropathic pain	off-label use	247398009
Chronic pruritus	off-label use	418363000
Refractory pruritis	off-label use	418363000
Post-stroke nausea	off-label use	422587007
Essential tremor	off-label use	609558009	DOID:4990
Intractable hiccups	off-label use	716771000
Acute postoperative pain	off-label use	107401000119105
Suicidal thoughts	contraindication	6471006
Depressive disorder	contraindication	35489007
Kidney disease	contraindication	90708001	DOID:557

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	4.02	acidic
pKa2	10.31	Basic

Orange Book patent data (new drug applications)

Formulation strength	Trade name	Applicant	Application number	Approval date	Type	Dose form	Route	Patent number	Patent expiration date	Patent use
300MG	GRALISE	ALMATICA	N022544	Jan. 28, 2011	RX	TABLET	ORAL	7438927	Feb. 26, 2024	TREATMENT WITH GABAPENTIN, INCLUDING TREATMENT OF NEUROPATHIC PAIN, INCLUDING NEUROPATHIC PAIN ASSOCIATED WITH POSTHERPETIC NEURALGIA
600MG	GRALISE	ALMATICA	N022544	Jan. 28, 2011	RX	TABLET	ORAL	7438927	Feb. 26, 2024	TREATMENT WITH GABAPENTIN, INCLUDING TREATMENT OF NEUROPATHIC PAIN, INCLUDING NEUROPATHIC PAIN ASSOCIATED WITH POSTHERPETIC NEURALGIA

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Voltage-dependent calcium channel subunit alpha-2/delta-2	Ion channel	Q9NY47	CA2D2_HUMAN	MODULATOR	IC50	6.93	SCIENTIFIC LITERATURE	SCIENTIFIC LITERATURE
Voltage-dependent calcium channel subunit alpha-2/delta-1	Ion channel	P54289	CA2D1_HUMAN	MODULATOR	IC50	7.26	WOMBAT-PK	CHEMBL
Adenosine receptor A1	GPCR	P30542	AA1R_HUMAN				WOMBAT-PK
Gamma-aminobutyric acid type B receptor subunit 2	GPCR	O75899	GABR2_HUMAN				WOMBAT-PK
Glutamate receptor ionotropic, NMDA 3A	Ion channel	Q8TCU5	NMD3A_HUMAN				WOMBAT-PK
Large neutral amino acids transporter small subunit 1	Transporter	Q01650	LAT1_HUMAN		IC50	4.52	WOMBAT-PK
Sodium channel protein type 5 subunit alpha	Ion channel	Q14524	SCN5A_HUMAN				WOMBAT-PK
Potassium voltage-gated channel subfamily KQT member 3	Ion channel	O43525	KCNQ3_HUMAN	ACTIVATOR	EC50	8.28	IUPHAR
Potassium voltage-gated channel subfamily KQT member 5	Ion channel	Q9NR82	KCNQ5_HUMAN	ACTIVATOR	EC50	8.72	IUPHAR
Alpha-2A adrenergic receptor	GPCR	P08913	ADA2A_HUMAN				WOMBAT-PK
Voltage-dependent calcium channel subunit alpha-2/delta-1	Ion channel		CA2D1_MOUSE		Ki	6.92	CHEMBL
Uncharacterized protein; Voltage-dependent calcium channel alpha-2 delta subunit	Ion channel		O77773_PIG		IC50	7.15	CHEMBL

External reference:

ID	Source
4020833	VUID
N0000148345	NUI
D00332	KEGG_DRUG
4020833	VANDF
C0060926	UMLSCUI
CHEBI:42797	CHEBI
GBN	PDB_CHEM_ID
CHEMBL940	ChEMBL_ID
DB00996	DRUGBANK_ID
D000077206	MESH_DESCRIPTOR_UI
3446	PUBCHEM_CID
5094	INN_ID
C081867	MESH_SUPPLEMENTAL_RECORD_UI
5483	IUPHAR_LIGAND_ID
6CW7F3G59X	UNII
196498	RXNORM
2269	MMSL
4770	MMSL
60712	MMSL
d03182	MMSL
004415	NDDF
108402001	SNOMEDCT_US
386845007	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Neurontin	HUMAN PRESCRIPTION DRUG LABEL	1	0071-0401	TABLET, FILM COATED	800 mg	ORAL	NDA	31 sections
Neurontin	HUMAN PRESCRIPTION DRUG LABEL	1	0071-0401	TABLET, FILM COATED	800 mg	ORAL	NDA	31 sections
Neurontin	HUMAN PRESCRIPTION DRUG LABEL	1	0071-0401	TABLET, FILM COATED	800 mg	ORAL	NDA	31 sections
Neurontin	HUMAN PRESCRIPTION DRUG LABEL	1	0071-0513	TABLET, FILM COATED	600 mg	ORAL	NDA	31 sections
Neurontin	HUMAN PRESCRIPTION DRUG LABEL	1	0071-0513	TABLET, FILM COATED	600 mg	ORAL	NDA	31 sections
Neurontin	HUMAN PRESCRIPTION DRUG LABEL	1	0071-0513	TABLET, FILM COATED	600 mg	ORAL	NDA	31 sections
Neurontin	HUMAN PRESCRIPTION DRUG LABEL	1	0071-0803	CAPSULE	100 mg	ORAL	NDA	31 sections
Neurontin	HUMAN PRESCRIPTION DRUG LABEL	1	0071-0803	CAPSULE	100 mg	ORAL	NDA	31 sections
Neurontin	HUMAN PRESCRIPTION DRUG LABEL	1	0071-0803	CAPSULE	100 mg	ORAL	NDA	31 sections
Neurontin	HUMAN PRESCRIPTION DRUG LABEL	1	0071-0805	CAPSULE	300 mg	ORAL	NDA	31 sections
Neurontin	HUMAN PRESCRIPTION DRUG LABEL	1	0071-0805	CAPSULE	300 mg	ORAL	NDA	31 sections
Neurontin	HUMAN PRESCRIPTION DRUG LABEL	1	0071-0805	CAPSULE	300 mg	ORAL	NDA	31 sections
Neurontin	HUMAN PRESCRIPTION DRUG LABEL	1	0071-0806	CAPSULE	400 mg	ORAL	NDA	31 sections
Neurontin	HUMAN PRESCRIPTION DRUG LABEL	1	0071-0806	CAPSULE	400 mg	ORAL	NDA	31 sections
Neurontin	HUMAN PRESCRIPTION DRUG LABEL	1	0071-0806	CAPSULE	400 mg	ORAL	NDA	31 sections
Neurontin	HUMAN PRESCRIPTION DRUG LABEL	1	0071-2012	SOLUTION	250 mg	ORAL	NDA	31 sections
Neurontin	HUMAN PRESCRIPTION DRUG LABEL	1	0071-2012	SOLUTION	250 mg	ORAL	NDA	31 sections
Neurontin	HUMAN PRESCRIPTION DRUG LABEL	1	0071-2012	SOLUTION	250 mg	ORAL	NDA	31 sections
Gabapentin	HUMAN PRESCRIPTION DRUG LABEL	1	0228-2636	TABLET, FILM COATED	600 mg	ORAL	ANDA	26 sections
Gabapentin	HUMAN PRESCRIPTION DRUG LABEL	1	0228-2636	TABLET, FILM COATED	600 mg	ORAL	ANDA	26 sections
Gabapentin	HUMAN PRESCRIPTION DRUG LABEL	1	0228-2637	TABLET, FILM COATED	800 mg	ORAL	ANDA	26 sections
Gabapentin	HUMAN PRESCRIPTION DRUG LABEL	1	0228-2637	TABLET, FILM COATED	800 mg	ORAL	ANDA	26 sections
GABAPENTIN	HUMAN PRESCRIPTION DRUG LABEL	1	0440-5562	TABLET, FILM COATED	600 mg	ORAL	ANDA	24 sections
GABAPENTIN	HUMAN PRESCRIPTION DRUG LABEL	1	0440-5563	TABLET, FILM COATED	800 mg	ORAL	ANDA	24 sections
Gabapentin	HUMAN PRESCRIPTION DRUG LABEL	1	0440-7559	CAPSULE	300 mg	ORAL	ANDA	14 sections
Gabapentin	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8132	TABLET	800 mg	ORAL	ANDA	29 sections
Gabapentin	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8132	TABLET	800 mg	ORAL	ANDA	29 sections
Gabapentin	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8230	CAPSULE	100 mg	ORAL	ANDA	29 sections
Gabapentin	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8231	CAPSULE	300 mg	ORAL	ANDA	29 sections
Gabapentin	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8232	CAPSULE	400 mg	ORAL	ANDA	29 sections