ftivazide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
1253 149-17-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • anhydrous ftivazide
  • ftivazide
  • ftivazid
  • N-Isonicotinamido-3-methoxy-4-hydroxybenzalimine
  • phthivazid
  • phthivazide
  • vanillaberon
  • vanizide
  • Molecular weight: 271.28
  • Formula: C14H13N3O3
  • CLOGP: 1.54
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 2
  • TPSA: 83.81
  • ALOGS: -3.14
  • ROTB: 4

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,ALK,AURKA,AURKB,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,CHEK1,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK1,GRK2,GRK3,GSK3B,ITK,JAK1,JAK2,KIT,MAP2K6,MAP3K1,MAP3K21,MAP3K7,MAP4K1,MAPK1,MAPK12,MAPK7,MAPK9,MAPKAPK2,MARK4,MTOR,NTRK2,PAK4,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIK3CD,PIK3CG,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1 58
kinase-selectivity-class ACVR2A,ACVR2B,ALK,AXL,BRAF,CAMK2B,CAMK2D,CDK1,CDK9,DDR1,DYRK1B,EPHB4,ERBB2,ERBB4,GRK2,GSK3B,IRAK1,IRAK3,JAK1,MAP2K3,MAP2K6,MAP3K21,MAP4K1,MAP4K3,MAPK7,MARK4,MINK1,PIK3CB,PIK3CD,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TNIK,TTK,ULK1,ULK2 41
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC J04AC02 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIMYCOBACTERIALS
DRUGS FOR TREATMENT OF TUBERCULOSIS
Hydrazides
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000960 Hypolipidemic Agents
MeSH PA D000963 Antimetabolites
MeSH PA D000995 Antitubercular Agents
MeSH PA D054872 Fatty Acid Synthesis Inhibitors

Related Drugs by ATC class:

J04AC Hydrazides 1 drug
isoniazid

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Tuberculosis indication 56717001




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.51 acidic
pKa2 10.3 acidic
pKa3 4.53 Basic
pKa4 3.56 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Myeloperoxidase Enzyme IC50 6.34 CHEMBL

External reference:

IDSource
C0086317 UMLSCUI
CHEMBL2105120 ChEMBL_ID
135412163 PUBCHEM_CID
1087 INN_ID
40Q4C3O4V0 UNII
D007538 MESH_DESCRIPTOR_UI
CHEBI:135117 CHEBI

Pharmaceutical products:

None