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fructose 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 1252 | 6347-01-9 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A monosaccharide in sweet fruits and honey that is soluble in water, alcohol, or ether. It is used as a preservative and an intravenous infusion in parenteral feeding.
|
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 24 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,AXL,BRAF,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,ERBB2,GRK2,ITK,MAP2K6,MAP3K21,MAPK10,MAPK7,NTRK2,PDK2,PDK4,PIK3CD,PRKDC,SIK2,STK33,TEK | 25 | |||
| kinase-selectivity-class | ACVRL1,AURKB,AXL,BMX,BRAF,CDK1,CDK2,CDK4,CDK6,CDK7,CDK8,CDK9,CHUK,DYRK1A,EPHB4,IGF1R,INSR,IRAK1,IRAK3,IRAK4,KIT,MAP2K6,MAP3K14,MAP3K21,PDK1,PIK3CD,PIK3CG,PRKDC,SYK,TEK,TGFBR1,ZAP70 | 32 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Vaginal flatulence | 382.76 | 275.67 | 88 | 2968 | 12550 | 90612841 |
| Proctitis | 366.26 | 275.67 | 88 | 2968 | 15171 | 90610220 |
| Female genital tract fistula | 357.47 | 275.67 | 89 | 2967 | 17779 | 90607612 |
| Radiculopathy | 349.39 | 275.67 | 88 | 2968 | 18417 | 90606974 |
| Vaginal discharge | 344.98 | 275.67 | 88 | 2968 | 19376 | 90606015 |
| Chronic sinusitis | 332.15 | 275.67 | 89 | 2967 | 23713 | 90601678 |
| Paraesthesia oral | 311.48 | 275.67 | 90 | 2966 | 31569 | 90593822 |
| Macular degeneration | 299.61 | 275.67 | 91 | 2965 | 37879 | 90587512 |
| Oral candidiasis | 292.73 | 275.67 | 88 | 2968 | 35367 | 90590024 |
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Vaginal flatulence | 398.45 | 227.62 | 87 | 2957 | 12057 | 110574198 |
| Female genital tract fistula | 377.09 | 227.62 | 88 | 2956 | 16431 | 110569824 |
| Proctitis | 369.69 | 227.62 | 87 | 2957 | 16840 | 110569415 |
| Vaginal discharge | 364.81 | 227.62 | 87 | 2957 | 17821 | 110568434 |
| Radiculopathy | 358.18 | 227.62 | 87 | 2957 | 19249 | 110567006 |
| Macular degeneration | 353.39 | 227.62 | 88 | 2956 | 21571 | 110564684 |
| Chronic sinusitis | 340.56 | 227.62 | 88 | 2956 | 24996 | 110561259 |
| Paraesthesia oral | 319.47 | 227.62 | 89 | 2955 | 33582 | 110552673 |
| Oral candidiasis | 285.83 | 227.62 | 87 | 2957 | 44673 | 110541582 |
| Frequent bowel movements | 249.75 | 227.62 | 88 | 2956 | 71302 | 110514953 |
| Colitis ulcerative | 239.10 | 227.62 | 87 | 2957 | 77276 | 110508979 |
| Procedural pain | 230.65 | 227.62 | 70 | 2974 | 35495 | 110550760 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | V06DC02 | VARIOUS GENERAL NUTRIENTS OTHER NUTRIENTS Carbohydrates |
| MeSH PA | D005421 | Flavoring Agents |
| MeSH PA | D005503 | Food Additives |
| MeSH PA | D013549 | Sweetening Agents |
| CHEBI has role | CHEBI:78675 | fundamental metabolite |
| CHEBI has role | CHEBI:50505 | sweetening agent |
Related Drugs by ATC class:
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 12.38 | acidic |
| pKa2 | 13.19 | acidic |
| pKa3 | 13.63 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Glycine receptor subunit alpha-1 | Ion channel | EC50 | 4.90 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4018693 | VUID |
| N0000147002 | NUI |
| D00114 | KEGG_DRUG |
| 4018693 | VANDF |
| C0016745 | UMLSCUI |
| CHEBI:28645 | CHEBI |
| BDF | PDB_CHEM_ID |
| CHEMBL1232863 | ChEMBL_ID |
| DB04173 | DRUGBANK_ID |
| D005632 | MESH_DESCRIPTOR_UI |
| 2723872 | PUBCHEM_CID |
| 6YSS42VSEV | UNII |
| 4570 | RXNORM |
| NOCODE | MMSL |
| 000918 | NDDF |
| 002606 | NDDF |
| 39860005 | SNOMEDCT_US |
| 58202007 | SNOMEDCT_US |
| 57-48-7 | SECONDARY_CAS_RN |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Walgreen Anti Nausea Cherry Flavor | HUMAN OTC DRUG LABEL | 3 | 0363-7080 | SOLUTION | 1.87 g | ORAL | unapproved drug other | 13 sections |
| WALGREENCHILDREN ANTI NAUSEA | HUMAN OTC DRUG LABEL | 3 | 0363-7081 | SOLUTION | 1.87 g | ORAL | Unapproved drug other | 13 sections |
| Anti Nausea | HUMAN OTC DRUG LABEL | 3 | 0536-1302 | LIQUID | 1.87 g | ORAL | Unapproved drug other | 13 sections |
| Anti Nausea | HUMAN OTC DRUG LABEL | 3 | 0536-1302 | LIQUID | 1.87 g | ORAL | Unapproved drug other | 13 sections |
| Kroger Anti Nausea Cherry Flavor | HUMAN OTC DRUG LABEL | 3 | 30142-708 | LIQUID | 1.87 g | ORAL | unapproved drug other | 13 sections |
| Anti Nausea Liquid | HUMAN OTC DRUG LABEL | 3 | 36800-708 | SOLUTION | 1.87 g | ORAL | Unapproved drug other | 13 sections |
| Anti Nausea Liquid | HUMAN OTC DRUG LABEL | 3 | 36800-708 | SOLUTION | 1.87 g | ORAL | Unapproved drug other | 13 sections |
| HEB Anti Nausea | HUMAN OTC DRUG LABEL | 3 | 37808-883 | LIQUID | 1.87 g | ORAL | unapproved drug other | 13 sections |
| Meijer Anti Nausea | HUMAN OTC DRUG LABEL | 3 | 41250-495 | LIQUID | 1.87 g | ORAL | Unapproved drug other | 13 sections |
| Meijer Anti Nausea | HUMAN OTC DRUG LABEL | 3 | 41250-495 | LIQUID | 1.87 g | ORAL | Unapproved drug other | 13 sections |
| Good Neighbor Anti NauseaCherry Flavor | HUMAN OTC DRUG LABEL | 3 | 46122-729 | LIQUID | 1.87 g | ORAL | Unapproved drug other | 13 sections |
| Nauzene | HUMAN OTC DRUG LABEL | 3 | 52389-172 | SYRUP | 4.17 g | ORAL | OTC monograph not final | 14 sections |
| Discount Drug Mart nausea control Cherry Flavor | HUMAN OTC DRUG LABEL | 3 | 53943-708 | SOLUTION | 1.87 g | ORAL | unapproved drug other | 13 sections |
| Anti Nausea Liquid Cherry Flavor | HUMAN OTC DRUG LABEL | 3 | 63868-704 | SOLUTION | 1.87 g | ORAL | unapproved drug other | 13 sections |
| Best Choice Anti NauseaCherry Flavor | HUMAN OTC DRUG LABEL | 3 | 63941-708 | LIQUID | 1.87 g | ORAL | Unapproved drug other | 13 sections |
| Emetrol Cherry | HUMAN OTC DRUG LABEL | 3 | 65197-201 | SOLUTION | 1.87 g | ORAL | unapproved drug other | 13 sections |
| Emetrol Children Mixed Berry | HUMAN OTC DRUG LABEL | 3 | 65197-202 | SOLUTION | 1.87 g | ORAL | unapproved drug other | 14 sections |
| Premier Value Nausea ControlCherry Flavor | HUMAN OTC DRUG LABEL | 3 | 68016-807 | SOLUTION | 1.87 g | ORAL | Unapproved drug other | 13 sections |
| CVS Anti Nausea Cherry Flavor | HUMAN OTC DRUG LABEL | 3 | 69842-708 | LIQUID | 1.87 g | ORAL | unapproved drug other | 13 sections |
| Anti Nausea | HUMAN OTC DRUG LABEL | 3 | 70000-0052 | LIQUID | 1.87 g | ORAL | Unapproved drug other | 13 sections |
| Anti Nausea | HUMAN OTC DRUG LABEL | 3 | 70000-0052 | LIQUID | 1.87 g | ORAL | Unapproved drug other | 13 sections |
| QUALITY CHOICE Anti-Nausea | HUMAN OTC DRUG LABEL | 3 | 83324-217 | SOLUTION | 1.87 g | ORAL | unapproved drug other | 13 sections |