dimetotiazine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1235 7456-24-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • dimetotiazine mesilate
  • fonazine mesylate
  • fonazine
  • dimethiotazine
  • dimethothiazine
  • dimetotiazine
has considerable antiemetic & serotonin antagonistic action used mainly in allergic skin conditions; minor descriptor (75-84); on-line & Index Medicus search PHENOTHIAZINES (75-84); RN given refers to parent cpd
  • Molecular weight: 391.55
  • Formula: C19H25N3O2S2
  • CLOGP: 3.23
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 0
  • TPSA: 43.86
  • ALOGS: -3.78
  • ROTB: 4

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N02CX05 NERVOUS SYSTEM
ANALGESICS
ANTIMIGRAINE PREPARATIONS
Other antimigraine preparations
MeSH PA D018494 Histamine Agents
MeSH PA D006633 Histamine Antagonists
MeSH PA D006634 Histamine H1 Antagonists
MeSH PA D018377 Neurotransmitter Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.19 Basic
pKa2 3.06 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D07854 KEGG_DRUG
13115-40-7 SECONDARY_CAS_RN
C0118092 UMLSCUI
CHEBI:135616 CHEBI
CHEMBL346977 ChEMBL_ID
CHEMBL2104669 ChEMBL_ID
DB08967 DRUGBANK_ID
C100113 MESH_SUPPLEMENTAL_RECORD_UI
3089 PUBCHEM_CID
50138 RXNORM
003519 NDDF
003520 NDDF
2034 INN_ID
B28V86NGNK UNII

Pharmaceutical products:

None