Stem definition | Drug id | CAS RN |
---|---|---|
serotonin and/or norepinephrine reuptake inhibitors, fluoxetine derivatives | 1209 | 54910-89-3 |
Dose | Unit | Route |
---|---|---|
20 | mg | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 15.20 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 1.25 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 4.30 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 60 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Date | Agency | Company | Orphan |
---|---|---|---|
Dec. 29, 1987 | FDA | ELI LILLY AND CO |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Completed suicide | 1502.04 | 9.86 | 1760 | 139140 | 132073 | 56019094 |
Intentional overdose | 873.53 | 9.86 | 961 | 139939 | 67156 | 56084011 |
Toxicity to various agents | 804.63 | 9.86 | 1750 | 139150 | 222814 | 55928353 |
Suicidal ideation | 786.35 | 9.86 | 841 | 140059 | 56901 | 56094266 |
Serotonin syndrome | 599.52 | 9.86 | 511 | 140389 | 25979 | 56125188 |
Drug abuse | 599.36 | 9.86 | 791 | 140109 | 66819 | 56084348 |
Depression | 548.35 | 9.86 | 1317 | 139583 | 178800 | 55972367 |
Suicide attempt | 534.88 | 9.86 | 691 | 140209 | 57145 | 56094022 |
Intentional self-injury | 503.00 | 9.86 | 451 | 140449 | 24541 | 56126626 |
Drug interaction | 480.29 | 9.86 | 1379 | 139521 | 208376 | 55942791 |
Anxiety | 422.89 | 9.86 | 1250 | 139650 | 191922 | 55959245 |
Rheumatoid arthritis | 369.67 | 9.86 | 253 | 140647 | 382351 | 55768816 |
Electrocardiogram QT prolonged | 351.78 | 9.86 | 549 | 140351 | 54039 | 56097128 |
Systemic lupus erythematosus | 340.08 | 9.86 | 30 | 140870 | 180048 | 55971119 |
Tremor | 327.59 | 9.86 | 847 | 140053 | 120242 | 56030925 |
Synovitis | 321.19 | 9.86 | 21 | 140879 | 161284 | 55989883 |
Hand deformity | 306.86 | 9.86 | 6 | 140894 | 134486 | 56016681 |
Agitation | 287.82 | 9.86 | 509 | 140391 | 55527 | 56095640 |
Contraindicated product administered | 285.90 | 9.86 | 59 | 140841 | 186227 | 55964940 |
Drug intolerance | 270.68 | 9.86 | 164 | 140736 | 264654 | 55886513 |
Glossodynia | 256.37 | 9.86 | 38 | 140862 | 152420 | 55998747 |
Joint swelling | 256.01 | 9.86 | 210 | 140690 | 289590 | 55861577 |
Cardio-respiratory arrest | 251.86 | 9.86 | 477 | 140423 | 54844 | 56096323 |
Overdose | 248.72 | 9.86 | 703 | 140197 | 105127 | 56046040 |
Treatment failure | 243.48 | 9.86 | 63 | 140837 | 170329 | 55980838 |
Drug withdrawal syndrome | 242.12 | 9.86 | 311 | 140589 | 25546 | 56125621 |
Infusion related reaction | 228.37 | 9.86 | 119 | 140781 | 208812 | 55942355 |
Wound | 227.91 | 9.86 | 37 | 140863 | 138767 | 56012400 |
Alopecia | 220.28 | 9.86 | 246 | 140654 | 293212 | 55857955 |
Withdrawal syndrome | 216.73 | 9.86 | 249 | 140651 | 18213 | 56132954 |
Cardiac arrest | 209.29 | 9.86 | 580 | 140320 | 85734 | 56065433 |
Pericarditis | 208.70 | 9.86 | 17 | 140883 | 108906 | 56042261 |
Poisoning | 201.92 | 9.86 | 202 | 140698 | 12611 | 56138556 |
Respiratory arrest | 201.40 | 9.86 | 311 | 140589 | 30314 | 56120853 |
Arthropathy | 199.05 | 9.86 | 128 | 140772 | 200147 | 55951020 |
Swelling | 195.70 | 9.86 | 187 | 140713 | 239584 | 55911583 |
Irritability | 192.52 | 9.86 | 299 | 140601 | 29289 | 56121878 |
Rash | 188.66 | 9.86 | 620 | 140280 | 492427 | 55658740 |
Abdominal discomfort | 187.42 | 9.86 | 252 | 140648 | 277022 | 55874145 |
Somnolence | 187.37 | 9.86 | 858 | 140042 | 162555 | 55988612 |
Peripheral swelling | 171.46 | 9.86 | 201 | 140699 | 234525 | 55916642 |
Reversible cerebral vasoconstriction syndrome | 160.46 | 9.86 | 90 | 140810 | 2287 | 56148880 |
Rheumatoid factor positive | 153.90 | 9.86 | 4 | 140896 | 69056 | 56082111 |
Drug ineffective | 151.86 | 9.86 | 1522 | 139378 | 917467 | 55233700 |
Akathisia | 150.52 | 9.86 | 144 | 140756 | 8508 | 56142659 |
Torsade de pointes | 149.76 | 9.86 | 170 | 140730 | 12270 | 56138897 |
Hepatic enzyme increased | 147.72 | 9.86 | 127 | 140773 | 171257 | 55979910 |
Sopor | 146.81 | 9.86 | 219 | 140681 | 20703 | 56130464 |
Therapeutic product effect decreased | 146.74 | 9.86 | 125 | 140775 | 169327 | 55981840 |
Nightmare | 146.05 | 9.86 | 195 | 140705 | 16631 | 56134536 |
Aggression | 142.62 | 9.86 | 222 | 140678 | 21784 | 56129383 |
Helicobacter infection | 141.55 | 9.86 | 11 | 140889 | 73257 | 56077910 |
Disturbance in attention | 141.20 | 9.86 | 275 | 140625 | 32265 | 56118902 |
Duodenal ulcer perforation | 138.66 | 9.86 | 8 | 140892 | 68334 | 56082833 |
Discomfort | 137.54 | 9.86 | 93 | 140807 | 141668 | 56009499 |
Arthralgia | 134.58 | 9.86 | 723 | 140177 | 500946 | 55650221 |
Depressed mood | 133.78 | 9.86 | 287 | 140613 | 36072 | 56115095 |
Product use issue | 132.94 | 9.86 | 162 | 140738 | 185879 | 55965288 |
Infection | 128.17 | 9.86 | 189 | 140711 | 200017 | 55951150 |
Panic attack | 122.49 | 9.86 | 199 | 140701 | 20248 | 56130919 |
Suicidal behaviour | 119.42 | 9.86 | 75 | 140825 | 2358 | 56148809 |
Mania | 116.47 | 9.86 | 144 | 140756 | 11376 | 56139791 |
Poisoning deliberate | 116.41 | 9.86 | 134 | 140766 | 9819 | 56141348 |
Febrile neutropenia | 115.39 | 9.86 | 60 | 140840 | 105485 | 56045682 |
Crying | 111.63 | 9.86 | 196 | 140704 | 21244 | 56129923 |
White blood cell count abnormal | 110.40 | 9.86 | 102 | 140798 | 5765 | 56145402 |
Hypersensitivity | 110.29 | 9.86 | 305 | 140595 | 256103 | 55895064 |
Folliculitis | 109.82 | 9.86 | 7 | 140893 | 54972 | 56096195 |
Product complaint | 109.37 | 9.86 | 141 | 140759 | 11619 | 56139548 |
Mydriasis | 104.94 | 9.86 | 134 | 140766 | 10937 | 56140230 |
Coma | 104.53 | 9.86 | 358 | 140542 | 59297 | 56091870 |
Foetal exposure during pregnancy | 104.38 | 9.86 | 249 | 140651 | 33574 | 56117593 |
Seizure | 103.57 | 9.86 | 600 | 140300 | 124519 | 56026648 |
Blister | 103.52 | 9.86 | 73 | 140827 | 108814 | 56042353 |
Product substitution issue | 99.83 | 9.86 | 151 | 140749 | 14448 | 56136719 |
Lower respiratory tract infection | 98.95 | 9.86 | 85 | 140815 | 114709 | 56036458 |
Muscle injury | 98.33 | 9.86 | 9 | 140891 | 52491 | 56098676 |
Nasopharyngitis | 94.87 | 9.86 | 263 | 140637 | 220696 | 55930471 |
Respiratory depression | 91.32 | 9.86 | 133 | 140767 | 12302 | 56138865 |
Sleep disorder due to general medical condition, insomnia type | 91.31 | 9.86 | 4 | 140896 | 43334 | 56107833 |
Obsessive-compulsive disorder | 88.96 | 9.86 | 74 | 140826 | 3632 | 56147535 |
Stomatitis | 88.60 | 9.86 | 103 | 140797 | 120707 | 56030460 |
Muscle rigidity | 88.54 | 9.86 | 121 | 140779 | 10550 | 56140617 |
Impaired healing | 88.26 | 9.86 | 54 | 140846 | 86787 | 56064380 |
Suspected suicide | 87.64 | 9.86 | 87 | 140813 | 5379 | 56145788 |
Coma scale abnormal | 86.61 | 9.86 | 82 | 140818 | 4781 | 56146386 |
Galactorrhoea | 85.75 | 9.86 | 74 | 140826 | 3821 | 56147346 |
Self-injurious ideation | 85.24 | 9.86 | 60 | 140840 | 2290 | 56148877 |
Dystonia | 82.85 | 9.86 | 127 | 140773 | 12294 | 56138873 |
Insomnia | 82.81 | 9.86 | 788 | 140112 | 191072 | 55960095 |
Tardive dyskinesia | 82.17 | 9.86 | 101 | 140799 | 7930 | 56143237 |
Neutropenia | 81.52 | 9.86 | 171 | 140729 | 157996 | 55993171 |
Muscle twitching | 80.08 | 9.86 | 145 | 140755 | 16097 | 56135070 |
Pneumonia | 79.98 | 9.86 | 644 | 140256 | 406454 | 55744713 |
Depressed level of consciousness | 79.80 | 9.86 | 316 | 140584 | 56117 | 56095050 |
Anger | 77.37 | 9.86 | 119 | 140781 | 11553 | 56139614 |
Mood swings | 75.67 | 9.86 | 144 | 140756 | 16603 | 56134564 |
General physical health deterioration | 73.96 | 9.86 | 201 | 140699 | 169809 | 55981358 |
Restlessness | 73.85 | 9.86 | 188 | 140712 | 26398 | 56124769 |
Miosis | 72.50 | 9.86 | 86 | 140814 | 6506 | 56144661 |
Off label use | 72.31 | 9.86 | 970 | 139930 | 555210 | 55595957 |
Abnormal behaviour | 72.25 | 9.86 | 158 | 140742 | 20114 | 56131053 |
Hyperhidrosis | 71.93 | 9.86 | 442 | 140458 | 93646 | 56057521 |
Bezoar | 71.78 | 9.86 | 44 | 140856 | 1324 | 56149843 |
Gastrointestinal disorder | 70.51 | 9.86 | 108 | 140792 | 112594 | 56038573 |
Tearfulness | 69.92 | 9.86 | 65 | 140835 | 3703 | 56147464 |
Electrocardiogram QRS complex prolonged | 69.72 | 9.86 | 77 | 140823 | 5390 | 56145777 |
Extrapyramidal disorder | 69.63 | 9.86 | 117 | 140783 | 12239 | 56138928 |
Hyperprolactinaemia | 69.57 | 9.86 | 64 | 140836 | 3597 | 56147570 |
Hypertonia neonatal | 68.41 | 9.86 | 25 | 140875 | 219 | 56150948 |
Generalised tonic-clonic seizure | 67.50 | 9.86 | 186 | 140714 | 27380 | 56123787 |
Drug dependence | 66.43 | 9.86 | 163 | 140737 | 22370 | 56128797 |
Pyrexia | 65.60 | 9.86 | 701 | 140199 | 418072 | 55733095 |
Parkinsonism | 64.23 | 9.86 | 98 | 140802 | 9448 | 56141719 |
Myoclonus | 64.14 | 9.86 | 127 | 140773 | 15076 | 56136091 |
Hallucination, auditory | 63.45 | 9.86 | 108 | 140792 | 11416 | 56139751 |
Restless legs syndrome | 62.58 | 9.86 | 134 | 140766 | 16813 | 56134354 |
Emotional distress | 62.43 | 9.86 | 190 | 140710 | 29573 | 56121594 |
Therapeutic product effect incomplete | 62.20 | 9.86 | 106 | 140794 | 105925 | 56045242 |
Pain | 62.20 | 9.86 | 1229 | 139671 | 661955 | 55489212 |
Memory impairment | 62.04 | 9.86 | 400 | 140500 | 86157 | 56065010 |
Mood altered | 61.78 | 9.86 | 116 | 140784 | 13239 | 56137928 |
Intentional product misuse | 61.58 | 9.86 | 274 | 140626 | 51230 | 56099937 |
Intentional product use issue | 59.15 | 9.86 | 99 | 140801 | 99634 | 56051533 |
Therapeutic response unexpected | 58.66 | 9.86 | 131 | 140769 | 16913 | 56134254 |
Dyskinesia | 58.44 | 9.86 | 183 | 140717 | 28925 | 56122242 |
Mobility decreased | 57.12 | 9.86 | 100 | 140800 | 98891 | 56052276 |
Ill-defined disorder | 56.36 | 9.86 | 53 | 140847 | 68490 | 56082677 |
Drug withdrawal syndrome neonatal | 56.34 | 9.86 | 44 | 140856 | 1972 | 56149195 |
Malignant neoplasm progression | 55.83 | 9.86 | 61 | 140839 | 73526 | 56077641 |
Sedation | 55.73 | 9.86 | 203 | 140697 | 34651 | 56116516 |
C-reactive protein increased | 55.64 | 9.86 | 69 | 140831 | 78615 | 56072552 |
Disease progression | 55.62 | 9.86 | 112 | 140788 | 105061 | 56046106 |
Cholecystitis chronic | 54.52 | 9.86 | 92 | 140808 | 9656 | 56141511 |
Confusional state | 53.99 | 9.86 | 775 | 140125 | 207380 | 55943787 |
Exposure during pregnancy | 53.91 | 9.86 | 550 | 140350 | 135792 | 56015375 |
Paranoia | 53.07 | 9.86 | 96 | 140804 | 10648 | 56140519 |
Abnormal dreams | 52.56 | 9.86 | 90 | 140810 | 9559 | 56141608 |
Stress cardiomyopathy | 52.48 | 9.86 | 83 | 140817 | 8253 | 56142914 |
Tic | 52.12 | 9.86 | 35 | 140865 | 1236 | 56149931 |
Hyperreflexia | 52.06 | 9.86 | 65 | 140835 | 5185 | 56145982 |
Hip arthroplasty | 51.92 | 9.86 | 16 | 140884 | 38607 | 56112560 |
Pancytopenia | 51.75 | 9.86 | 89 | 140811 | 88626 | 56062541 |
Myocardial depression | 51.65 | 9.86 | 25 | 140875 | 464 | 56150703 |
Cerebral vasoconstriction | 51.39 | 9.86 | 33 | 140867 | 1079 | 56150088 |
Libido increased | 51.11 | 9.86 | 35 | 140865 | 1277 | 56149890 |
Anaemia | 50.70 | 9.86 | 427 | 140473 | 267084 | 55884083 |
Pulseless electrical activity | 49.95 | 9.86 | 74 | 140826 | 6950 | 56144217 |
Atrial septal defect | 49.84 | 9.86 | 71 | 140829 | 6435 | 56144732 |
Sinus bradycardia | 49.68 | 9.86 | 107 | 140793 | 13479 | 56137688 |
Decorticate posture | 49.50 | 9.86 | 21 | 140879 | 282 | 56150885 |
Clonus | 49.34 | 9.86 | 57 | 140843 | 4192 | 56146975 |
Hostility | 49.09 | 9.86 | 39 | 140861 | 1792 | 56149375 |
Renal impairment | 48.90 | 9.86 | 79 | 140821 | 80634 | 56070533 |
Bradyphrenia | 48.89 | 9.86 | 71 | 140829 | 6549 | 56144618 |
Mucosal inflammation | 48.79 | 9.86 | 23 | 140877 | 42787 | 56108380 |
Platelet count decreased | 48.35 | 9.86 | 123 | 140777 | 106260 | 56044907 |
Sinusitis | 47.79 | 9.86 | 294 | 140606 | 197287 | 55953880 |
Thrombocytopenia | 47.36 | 9.86 | 178 | 140722 | 136046 | 56015121 |
Impulsive behaviour | 46.75 | 9.86 | 35 | 140865 | 1472 | 56149695 |
Maternal exposure during breast feeding | 45.88 | 9.86 | 51 | 140849 | 3596 | 56147571 |
Atrial fibrillation | 44.93 | 9.86 | 132 | 140768 | 108765 | 56042402 |
Accidental death | 44.85 | 9.86 | 37 | 140863 | 1795 | 56149372 |
Persistent genital arousal disorder | 44.80 | 9.86 | 20 | 140880 | 306 | 56150861 |
Major depression | 44.32 | 9.86 | 73 | 140827 | 7511 | 56143656 |
Tachycardia | 43.72 | 9.86 | 431 | 140469 | 105445 | 56045722 |
Depressive symptom | 43.66 | 9.86 | 49 | 140851 | 3492 | 56147675 |
Feeling abnormal | 43.65 | 9.86 | 519 | 140381 | 133083 | 56018084 |
Irritable bowel syndrome | 43.39 | 9.86 | 65 | 140835 | 68393 | 56082774 |
Knee arthroplasty | 42.94 | 9.86 | 29 | 140871 | 44230 | 56106937 |
Amnesia | 42.85 | 9.86 | 229 | 140671 | 46093 | 56105074 |
Alcohol interaction | 42.81 | 9.86 | 40 | 140860 | 2293 | 56148874 |
Blood pressure fluctuation | 42.55 | 9.86 | 24 | 140876 | 40336 | 56110831 |
Long QT syndrome | 42.15 | 9.86 | 45 | 140855 | 3031 | 56148136 |
Mental disorder | 41.63 | 9.86 | 142 | 140758 | 23462 | 56127705 |
Speech disorder | 41.50 | 9.86 | 195 | 140705 | 37298 | 56113869 |
Dyspnoea | 41.00 | 9.86 | 1150 | 139750 | 591427 | 55559740 |
Pre-eclampsia | 40.87 | 9.86 | 75 | 140825 | 8411 | 56142756 |
Dependence | 40.08 | 9.86 | 36 | 140864 | 1961 | 56149206 |
Blood hyposmosis | 40.04 | 9.86 | 10 | 140890 | 17 | 56151150 |
Ventricular fibrillation | 39.75 | 9.86 | 86 | 140814 | 10866 | 56140301 |
Agitation neonatal | 39.36 | 9.86 | 21 | 140879 | 482 | 56150685 |
Hyponatraemia | 38.92 | 9.86 | 409 | 140491 | 101730 | 56049437 |
Fear | 38.91 | 9.86 | 103 | 140797 | 14805 | 56136362 |
Euphoric mood | 38.57 | 9.86 | 51 | 140849 | 4307 | 56146860 |
Maternal drugs affecting foetus | 38.16 | 9.86 | 55 | 140845 | 5038 | 56146129 |
Dysarthria | 37.59 | 9.86 | 197 | 140703 | 39353 | 56111814 |
Unresponsive to stimuli | 37.33 | 9.86 | 168 | 140732 | 31557 | 56119610 |
Diarrhoea | 37.13 | 9.86 | 1268 | 139632 | 637239 | 55513928 |
Anorgasmia | 37.07 | 9.86 | 21 | 140879 | 544 | 56150623 |
Arthritis | 37.01 | 9.86 | 127 | 140773 | 99725 | 56051442 |
Cough | 35.62 | 9.86 | 448 | 140452 | 259513 | 55891654 |
Apathy | 35.44 | 9.86 | 68 | 140832 | 7886 | 56143281 |
Atrioventricular block first degree | 35.41 | 9.86 | 62 | 140838 | 6703 | 56144464 |
Sinus tachycardia | 35.27 | 9.86 | 130 | 140770 | 22314 | 56128853 |
Hallucination, visual | 35.23 | 9.86 | 110 | 140790 | 17358 | 56133809 |
Accidental overdose | 35.13 | 9.86 | 122 | 140778 | 20339 | 56130828 |
Traumatic coma | 34.41 | 9.86 | 11 | 140889 | 61 | 56151106 |
Red blood cell sedimentation rate increased | 34.20 | 9.86 | 25 | 140875 | 36598 | 56114569 |
Cogwheel rigidity | 34.10 | 9.86 | 32 | 140868 | 1845 | 56149322 |
Morbid thoughts | 34.04 | 9.86 | 20 | 140880 | 556 | 56150611 |
Respiration abnormal | 33.91 | 9.86 | 55 | 140845 | 5586 | 56145581 |
Ventricular hypokinesia | 33.89 | 9.86 | 47 | 140853 | 4154 | 56147013 |
Inappropriate antidiuretic hormone secretion | 33.85 | 9.86 | 93 | 140807 | 13663 | 56137504 |
Oculogyric crisis | 33.64 | 9.86 | 29 | 140871 | 1495 | 56149672 |
Mental impairment | 33.31 | 9.86 | 88 | 140812 | 12634 | 56138533 |
Hallucination | 33.30 | 9.86 | 224 | 140676 | 48925 | 56102242 |
Inflammation | 32.84 | 9.86 | 78 | 140822 | 68993 | 56082174 |
Stress | 32.72 | 9.86 | 256 | 140644 | 58654 | 56092513 |
Delusion of grandeur | 32.72 | 9.86 | 13 | 140887 | 146 | 56151021 |
Hypotonia neonatal | 32.43 | 9.86 | 25 | 140875 | 1099 | 56150068 |
Physical assault | 32.33 | 9.86 | 23 | 140877 | 893 | 56150274 |
Lethargy | 32.23 | 9.86 | 230 | 140670 | 51211 | 56099956 |
Cytomegalovirus infection | 31.97 | 9.86 | 5 | 140895 | 19291 | 56131876 |
Antipsychotic drug level increased | 31.93 | 9.86 | 40 | 140860 | 3202 | 56147965 |
Hypertonia | 31.85 | 9.86 | 45 | 140855 | 4047 | 56147120 |
Catatonia | 31.46 | 9.86 | 44 | 140856 | 3920 | 56147247 |
Binge eating | 31.33 | 9.86 | 17 | 140883 | 404 | 56150763 |
Blood prolactin increased | 31.28 | 9.86 | 40 | 140860 | 3269 | 56147898 |
Panic reaction | 31.13 | 9.86 | 43 | 140857 | 3787 | 56147380 |
Blood creatinine increased | 31.08 | 9.86 | 100 | 140800 | 80091 | 56071076 |
Cardiac failure | 30.70 | 9.86 | 104 | 140796 | 81989 | 56069178 |
Heart sounds | 30.57 | 9.86 | 21 | 140879 | 770 | 56150397 |
Herpes zoster | 30.57 | 9.86 | 93 | 140807 | 75796 | 56075371 |
Soft tissue injury | 30.47 | 9.86 | 28 | 140872 | 1571 | 56149596 |
Loss of libido | 30.33 | 9.86 | 25 | 140875 | 1211 | 56149956 |
Psychotic disorder | 30.19 | 9.86 | 128 | 140772 | 23430 | 56127737 |
Abortion missed | 30.10 | 9.86 | 28 | 140872 | 1596 | 56149571 |
Breech presentation | 29.95 | 9.86 | 24 | 140876 | 1117 | 56150050 |
Joint range of motion decreased | 29.88 | 9.86 | 13 | 140887 | 25352 | 56125815 |
Multiple sclerosis relapse | 29.44 | 9.86 | 203 | 140697 | 44700 | 56106467 |
Sternal fracture | 29.39 | 9.86 | 31 | 140869 | 2059 | 56149108 |
Neuropathy peripheral | 29.29 | 9.86 | 145 | 140755 | 102748 | 56048419 |
Migraine | 29.14 | 9.86 | 339 | 140561 | 86458 | 56064709 |
Talipes | 28.95 | 9.86 | 26 | 140874 | 1416 | 56149751 |
Urinary incontinence | 28.55 | 9.86 | 148 | 140752 | 29437 | 56121730 |
Prolonged expiration | 28.51 | 9.86 | 21 | 140879 | 861 | 56150306 |
Bulimia nervosa | 28.47 | 9.86 | 16 | 140884 | 408 | 56150759 |
Myelosuppression | 27.86 | 9.86 | 5 | 140895 | 17450 | 56133717 |
Fatigue | 27.79 | 9.86 | 1654 | 139246 | 786898 | 55364269 |
Burning mouth syndrome | 27.65 | 9.86 | 16 | 140884 | 432 | 56150735 |
Cystostomy | 27.42 | 9.86 | 9 | 140891 | 55 | 56151112 |
Drug level increased | 26.86 | 9.86 | 113 | 140787 | 20612 | 56130555 |
Concussion | 26.84 | 9.86 | 62 | 140838 | 8184 | 56142983 |
Maternal exposure during pregnancy | 26.57 | 9.86 | 325 | 140575 | 189228 | 55961939 |
Flat affect | 26.25 | 9.86 | 24 | 140876 | 1338 | 56149829 |
Drug abuser | 26.14 | 9.86 | 34 | 140866 | 2825 | 56148342 |
Pulmonary valve stenosis | 26.10 | 9.86 | 14 | 140886 | 325 | 56150842 |
Heart disease congenital | 26.04 | 9.86 | 23 | 140877 | 1225 | 56149942 |
Neoplasm progression | 26.03 | 9.86 | 25 | 140875 | 31991 | 56119176 |
Depression suicidal | 25.86 | 9.86 | 26 | 140874 | 1632 | 56149535 |
Musculoskeletal pain | 25.69 | 9.86 | 110 | 140790 | 81042 | 56070125 |
Poor quality sleep | 25.55 | 9.86 | 100 | 140800 | 17655 | 56133512 |
Attention-seeking behaviour | 25.45 | 9.86 | 9 | 140891 | 71 | 56151096 |
Protein C increased | 25.44 | 9.86 | 10 | 140890 | 109 | 56151058 |
Agoraphobia | 25.38 | 9.86 | 14 | 140886 | 344 | 56150823 |
Marital problem | 25.33 | 9.86 | 11 | 140889 | 157 | 56151010 |
Blood lactate dehydrogenase increased | 25.32 | 9.86 | 10 | 140890 | 20665 | 56130502 |
Disinhibition | 25.32 | 9.86 | 19 | 140881 | 802 | 56150365 |
Breast discomfort | 25.28 | 9.86 | 15 | 140885 | 425 | 56150742 |
Thinking abnormal | 25.25 | 9.86 | 68 | 140832 | 9873 | 56141294 |
Persistent foetal circulation | 25.12 | 9.86 | 12 | 140888 | 216 | 56150951 |
Septic shock | 24.90 | 9.86 | 74 | 140826 | 60761 | 56090406 |
Dysphoria | 24.86 | 9.86 | 44 | 140856 | 4798 | 56146369 |
Metabolic acidosis | 24.83 | 9.86 | 180 | 140720 | 40274 | 56110893 |
Erythema | 24.75 | 9.86 | 260 | 140640 | 155679 | 55995488 |
Posture abnormal | 24.71 | 9.86 | 29 | 140871 | 2169 | 56148998 |
Hypothermia | 24.66 | 9.86 | 78 | 140822 | 12392 | 56138775 |
Pleural effusion | 24.60 | 9.86 | 120 | 140780 | 85360 | 56065807 |
Trichotillomania | 24.58 | 9.86 | 10 | 140890 | 120 | 56151047 |
Affect lability | 24.47 | 9.86 | 68 | 140832 | 10057 | 56141110 |
Bone marrow failure | 24.29 | 9.86 | 21 | 140879 | 28265 | 56122902 |
Reduced facial expression | 24.13 | 9.86 | 26 | 140874 | 1770 | 56149397 |
Dissociation | 24.04 | 9.86 | 31 | 140869 | 2554 | 56148613 |
Dizziness | 23.98 | 9.86 | 1161 | 139739 | 374979 | 55776188 |
Self esteem decreased | 23.85 | 9.86 | 16 | 140884 | 564 | 56150603 |
Psychomotor hyperactivity | 23.78 | 9.86 | 66 | 140834 | 9754 | 56141413 |
Gallbladder disorder | 23.64 | 9.86 | 96 | 140804 | 17238 | 56133929 |
Multiple sclerosis | 23.41 | 9.86 | 134 | 140766 | 27668 | 56123499 |
Ventricular tachycardia | 23.37 | 9.86 | 94 | 140806 | 16807 | 56134360 |
White blood cell count decreased | 22.98 | 9.86 | 203 | 140697 | 125787 | 56025380 |
Respiratory disorder neonatal | 22.97 | 9.86 | 19 | 140881 | 925 | 56150242 |
Breast enlargement | 22.95 | 9.86 | 23 | 140877 | 1438 | 56149729 |
Pulmonary valve stenosis congenital | 22.95 | 9.86 | 10 | 140890 | 144 | 56151023 |
Emotional poverty | 22.94 | 9.86 | 13 | 140887 | 337 | 56150830 |
Heart rate | 22.86 | 9.86 | 8 | 140892 | 61 | 56151106 |
Borderline personality disorder | 22.77 | 9.86 | 17 | 140883 | 712 | 56150455 |
Disorientation | 22.53 | 9.86 | 163 | 140737 | 36450 | 56114717 |
Haemoglobin decreased | 22.37 | 9.86 | 221 | 140679 | 133916 | 56017251 |
Developmental delay | 22.30 | 9.86 | 22 | 140878 | 1350 | 56149817 |
Diet failure | 22.17 | 9.86 | 7 | 140893 | 37 | 56151130 |
Hypomania | 21.96 | 9.86 | 42 | 140858 | 4860 | 56146307 |
Food interaction | 21.90 | 9.86 | 17 | 140883 | 755 | 56150412 |
Acute kidney injury | 21.88 | 9.86 | 448 | 140452 | 240315 | 55910852 |
Loss of consciousness | 21.85 | 9.86 | 390 | 140510 | 108959 | 56042208 |
Infantile apnoea | 21.82 | 9.86 | 18 | 140882 | 873 | 56150294 |
Formication | 21.58 | 9.86 | 37 | 140863 | 3933 | 56147234 |
Induced abortion failed | 21.54 | 9.86 | 11 | 140889 | 230 | 56150937 |
Neonatal complications of substance abuse | 21.51 | 9.86 | 5 | 140895 | 5 | 56151162 |
Eye movement disorder | 21.41 | 9.86 | 41 | 140859 | 4748 | 56146419 |
Hyperthermia | 21.38 | 9.86 | 57 | 140843 | 8228 | 56142939 |
Narcolepsy | 21.29 | 9.86 | 21 | 140879 | 1288 | 56149879 |
Sleep-related eating disorder | 21.29 | 9.86 | 17 | 140883 | 787 | 56150380 |
Yawning | 21.17 | 9.86 | 19 | 140881 | 1034 | 56150133 |
Weight increased | 21.04 | 9.86 | 737 | 140163 | 228966 | 55922201 |
Psychomotor retardation | 21.01 | 9.86 | 35 | 140865 | 3634 | 56147533 |
CYP3A4 polymorphism | 20.96 | 9.86 | 8 | 140892 | 80 | 56151087 |
Leukocytosis | 20.91 | 9.86 | 116 | 140784 | 23675 | 56127492 |
Tongue biting | 20.69 | 9.86 | 21 | 140879 | 1333 | 56149834 |
Myasthenic syndrome | 20.67 | 9.86 | 11 | 140889 | 251 | 56150916 |
Neonatal hypoxia | 20.66 | 9.86 | 14 | 140886 | 502 | 56150665 |
Small for dates baby | 20.66 | 9.86 | 34 | 140866 | 3496 | 56147671 |
Dysphemia | 20.57 | 9.86 | 28 | 140872 | 2432 | 56148735 |
Eating disorder symptom | 20.44 | 9.86 | 9 | 140891 | 133 | 56151034 |
Post-traumatic neck syndrome | 20.44 | 9.86 | 25 | 140875 | 1953 | 56149214 |
Patent ductus arteriosus | 20.41 | 9.86 | 36 | 140864 | 3915 | 56147252 |
Aortic bruit | 20.36 | 9.86 | 6 | 140894 | 24 | 56151143 |
Affective disorder | 20.34 | 9.86 | 44 | 140856 | 5559 | 56145608 |
Gestational diabetes | 20.32 | 9.86 | 55 | 140845 | 8009 | 56143158 |
IIIrd nerve paresis | 20.32 | 9.86 | 9 | 140891 | 135 | 56151032 |
Blood pressure systolic increased | 20.31 | 9.86 | 45 | 140855 | 40791 | 56110376 |
Bipolar I disorder | 20.18 | 9.86 | 23 | 140877 | 1667 | 56149500 |
Psoriatic arthropathy | 20.09 | 9.86 | 106 | 140794 | 73902 | 56077265 |
Brugada syndrome | 20.03 | 9.86 | 12 | 140888 | 346 | 56150821 |
Gastric bypass | 20.01 | 9.86 | 22 | 140878 | 1532 | 56149635 |
Homicidal ideation | 19.98 | 9.86 | 23 | 140877 | 1685 | 56149482 |
Posterior segment of eye anomaly congenital | 19.97 | 9.86 | 4 | 140896 | 0 | 56151167 |
Feeling jittery | 19.97 | 9.86 | 71 | 140829 | 11975 | 56139192 |
Alcoholism | 19.78 | 9.86 | 26 | 140874 | 2183 | 56148984 |
Procedural hypertension | 19.77 | 9.86 | 11 | 140889 | 275 | 56150892 |
Plasma cell myeloma | 19.62 | 9.86 | 56 | 140844 | 46590 | 56104577 |
Nervousness | 19.51 | 9.86 | 132 | 140768 | 28883 | 56122284 |
Feeling guilty | 19.47 | 9.86 | 14 | 140886 | 553 | 56150614 |
Ideas of reference | 19.23 | 9.86 | 8 | 140892 | 102 | 56151065 |
Personality change | 19.22 | 9.86 | 44 | 140856 | 5773 | 56145394 |
Bruxism | 19.21 | 9.86 | 31 | 140869 | 3135 | 56148032 |
Cataplexy | 19.18 | 9.86 | 20 | 140880 | 1311 | 56149856 |
Primitive reflex test positive | 19.18 | 9.86 | 5 | 140895 | 11 | 56151156 |
Optic ischaemic neuropathy | 19.06 | 9.86 | 18 | 140882 | 1046 | 56150121 |
Drug tolerance decreased | 19.05 | 9.86 | 5 | 140895 | 13406 | 56137761 |
Electrolyte depletion | 18.89 | 9.86 | 9 | 140891 | 161 | 56151006 |
Gaze palsy | 18.88 | 9.86 | 20 | 140880 | 1335 | 56149832 |
Bone erosion | 18.74 | 9.86 | 7 | 140893 | 14967 | 56136200 |
Acute respiratory distress syndrome | 18.67 | 9.86 | 106 | 140794 | 21820 | 56129347 |
Bradykinesia | 18.64 | 9.86 | 39 | 140861 | 4815 | 56146352 |
Cholecystectomy | 18.63 | 9.86 | 60 | 140840 | 9624 | 56141543 |
Slow response to stimuli | 18.60 | 9.86 | 17 | 140883 | 947 | 56150220 |
Spinal shock | 18.59 | 9.86 | 5 | 140895 | 13 | 56151154 |
Somnambulism | 18.50 | 9.86 | 40 | 140860 | 5052 | 56146115 |
Neuroleptic malignant syndrome | 18.47 | 9.86 | 67 | 140833 | 11411 | 56139756 |
Drug screen positive | 18.46 | 9.86 | 32 | 140868 | 3432 | 56147735 |
Balance disorder | 18.27 | 9.86 | 281 | 140619 | 76239 | 56074928 |
Libido decreased | 18.04 | 9.86 | 26 | 140874 | 2382 | 56148785 |
Intrusive thoughts | 17.99 | 9.86 | 9 | 140891 | 180 | 56150987 |
Atrioventricular block second degree | 17.97 | 9.86 | 33 | 140867 | 3703 | 56147464 |
Drug hypersensitivity | 17.96 | 9.86 | 538 | 140362 | 274667 | 55876500 |
Oppositional defiant disorder | 17.84 | 9.86 | 6 | 140894 | 40 | 56151127 |
Atelectasis neonatal | 17.83 | 9.86 | 5 | 140895 | 16 | 56151151 |
Influenza like illness | 17.78 | 9.86 | 232 | 140668 | 60756 | 56090411 |
Drug eruption | 17.78 | 9.86 | 23 | 140877 | 25740 | 56125427 |
pH body fluid increased | 17.74 | 9.86 | 4 | 140896 | 3 | 56151164 |
Regurgitation | 17.72 | 9.86 | 20 | 140880 | 1434 | 56149733 |
Anterograde amnesia | 17.69 | 9.86 | 13 | 140887 | 531 | 56150636 |
Constipation | 17.68 | 9.86 | 378 | 140522 | 201565 | 55949602 |
Sepsis | 17.66 | 9.86 | 245 | 140655 | 139595 | 56011572 |
Pruritus | 17.57 | 9.86 | 632 | 140268 | 315991 | 55835176 |
Blood pressure measurement | 17.55 | 9.86 | 10 | 140890 | 262 | 56150905 |
Posterior reversible encephalopathy syndrome | 17.54 | 9.86 | 9 | 140891 | 15951 | 56135216 |
Hallucinations, mixed | 17.52 | 9.86 | 36 | 140864 | 4388 | 56146779 |
Sudden onset of sleep | 17.50 | 9.86 | 13 | 140887 | 540 | 56150627 |
Emotional disorder | 17.49 | 9.86 | 69 | 140831 | 12226 | 56138941 |
Prolonged labour | 17.46 | 9.86 | 13 | 140887 | 542 | 56150625 |
Hypercalcaemia | 17.22 | 9.86 | 23 | 140877 | 25388 | 56125779 |
Supraventricular tachyarrhythmia | 17.21 | 9.86 | 7 | 140893 | 84 | 56151083 |
Pre-existing condition improved | 17.20 | 9.86 | 49 | 140851 | 7349 | 56143818 |
Chronic fatigue syndrome | 17.16 | 9.86 | 17 | 140883 | 1048 | 56150119 |
Energy increased | 17.06 | 9.86 | 25 | 140875 | 2325 | 56148842 |
Incubator therapy | 17.00 | 9.86 | 6 | 140894 | 47 | 56151120 |
Serum sickness-like reaction | 17 | 9.86 | 12 | 140888 | 460 | 56150707 |
Road traffic accident | 16.99 | 9.86 | 124 | 140776 | 27803 | 56123364 |
Neonatal asphyxia | 16.80 | 9.86 | 10 | 140890 | 285 | 56150882 |
Congenital brain damage | 16.74 | 9.86 | 4 | 140896 | 5 | 56151162 |
Acute myeloid leukaemia | 16.62 | 9.86 | 11 | 140889 | 16961 | 56134206 |
Liver function test increased | 16.60 | 9.86 | 28 | 140872 | 28105 | 56123062 |
Pulmonary haemosiderosis | 16.59 | 9.86 | 5 | 140895 | 22 | 56151145 |
Prolonged rupture of membranes | 16.58 | 9.86 | 6 | 140894 | 51 | 56151116 |
Bipolar disorder | 16.47 | 9.86 | 49 | 140851 | 7531 | 56143636 |
Placenta praevia | 16.46 | 9.86 | 16 | 140884 | 964 | 56150203 |
Osteonecrosis of jaw | 16.39 | 9.86 | 37 | 140863 | 33321 | 56117846 |
Fibromyalgia | 16.39 | 9.86 | 85 | 140815 | 59518 | 56091649 |
Withdrawal catatonia | 16.38 | 9.86 | 6 | 140894 | 53 | 56151114 |
Disturbance in sexual arousal | 16.37 | 9.86 | 7 | 140893 | 96 | 56151071 |
Injury | 16.35 | 9.86 | 225 | 140675 | 59626 | 56091541 |
Polydactyly | 16.31 | 9.86 | 10 | 140890 | 301 | 56150866 |
Agonal rhythm | 16.24 | 9.86 | 5 | 140895 | 24 | 56151143 |
Tachyphrenia | 16.23 | 9.86 | 18 | 140882 | 1266 | 56149901 |
Foetal arrhythmia | 16.22 | 9.86 | 8 | 140892 | 155 | 56151012 |
Foetal alcohol syndrome | 16.07 | 9.86 | 5 | 140895 | 25 | 56151142 |
Anhedonia | 16.06 | 9.86 | 58 | 140842 | 9856 | 56141311 |
Decreased interest | 16.05 | 9.86 | 28 | 140872 | 3018 | 56148149 |
Paraesthesia | 16.01 | 9.86 | 434 | 140466 | 130080 | 56021087 |
Nystagmus | 15.97 | 9.86 | 41 | 140859 | 5784 | 56145383 |
Obsessive thoughts | 15.96 | 9.86 | 12 | 140888 | 508 | 56150659 |
Cholelithiasis | 15.96 | 9.86 | 160 | 140740 | 39304 | 56111863 |
Hypersomnia | 15.94 | 9.86 | 82 | 140818 | 16259 | 56134908 |
Blunted affect | 15.89 | 9.86 | 9 | 140891 | 233 | 56150934 |
Alcohol withdrawal syndrome | 15.78 | 9.86 | 14 | 140886 | 750 | 56150417 |
Phobia | 15.71 | 9.86 | 10 | 140890 | 322 | 56150845 |
Gait disturbance | 15.70 | 9.86 | 527 | 140373 | 162794 | 55988373 |
Appetite disorder | 15.66 | 9.86 | 44 | 140856 | 6549 | 56144618 |
Eosinophilic pneumonia acute | 15.65 | 9.86 | 10 | 140890 | 324 | 56150843 |
Analgesic drug level increased | 15.63 | 9.86 | 21 | 140879 | 1801 | 56149366 |
Osteoporosis | 15.60 | 9.86 | 72 | 140828 | 51980 | 56099187 |
Anorexia nervosa | 15.59 | 9.86 | 9 | 140891 | 242 | 56150925 |
Staring | 15.58 | 9.86 | 19 | 140881 | 1479 | 56149688 |
Tension | 15.57 | 9.86 | 27 | 140873 | 2897 | 56148270 |
Alcohol use | 15.37 | 9.86 | 22 | 140878 | 2003 | 56149164 |
Tooth hypoplasia | 15.29 | 9.86 | 6 | 140894 | 65 | 56151102 |
Parkinsonian gait | 15.13 | 9.86 | 11 | 140889 | 442 | 56150725 |
Sluggishness | 15.09 | 9.86 | 35 | 140865 | 4633 | 56146534 |
Skin ulcer | 15.06 | 9.86 | 48 | 140852 | 38560 | 56112607 |
Sleep paralysis | 14.96 | 9.86 | 12 | 140888 | 559 | 56150608 |
Oesophageal food impaction | 14.94 | 9.86 | 8 | 140892 | 185 | 56150982 |
Polyneuropathy | 14.88 | 9.86 | 7 | 140893 | 13043 | 56138124 |
Toxic epidermal necrolysis | 14.88 | 9.86 | 20 | 140880 | 22022 | 56129145 |
Creatinine renal clearance decreased | 14.86 | 9.86 | 9 | 140891 | 14550 | 56136617 |
Liver disorder | 14.75 | 9.86 | 59 | 140841 | 44311 | 56106856 |
Microcephaly | 14.72 | 9.86 | 14 | 140886 | 821 | 56150346 |
Umbilical cord around neck | 14.67 | 9.86 | 8 | 140892 | 192 | 56150975 |
Theft | 14.60 | 9.86 | 6 | 140894 | 74 | 56151093 |
Cleft palate | 14.55 | 9.86 | 15 | 140885 | 970 | 56150197 |
Chemical burn | 14.50 | 9.86 | 10 | 140890 | 369 | 56150798 |
Psychotic behaviour | 14.48 | 9.86 | 12 | 140888 | 586 | 56150581 |
Hypoprolactinaemia | 14.46 | 9.86 | 4 | 140896 | 12 | 56151155 |
Hyporesponsive to stimuli | 14.39 | 9.86 | 15 | 140885 | 983 | 56150184 |
Muscle enzyme increased | 14.36 | 9.86 | 7 | 140893 | 132 | 56151035 |
Hypoxic-ischaemic encephalopathy | 14.34 | 9.86 | 31 | 140869 | 3914 | 56147253 |
Feeling of despair | 14.34 | 9.86 | 22 | 140878 | 2131 | 56149036 |
Jaundice neonatal | 14.33 | 9.86 | 14 | 140886 | 849 | 56150318 |
Mononucleosis syndrome | 14.31 | 9.86 | 7 | 140893 | 133 | 56151034 |
Cold agglutinins positive | 14.30 | 9.86 | 5 | 140895 | 38 | 56151129 |
Abortion spontaneous | 14.28 | 9.86 | 170 | 140730 | 43583 | 56107584 |
Heavy menstrual bleeding | 14.22 | 9.86 | 79 | 140821 | 16130 | 56135037 |
Purple glove syndrome | 14.20 | 9.86 | 8 | 140892 | 205 | 56150962 |
Transient aphasia | 14.19 | 9.86 | 5 | 140895 | 39 | 56151128 |
Plasma cell mastitis | 14.19 | 9.86 | 5 | 140895 | 39 | 56151128 |
Hypnopompic hallucination | 14.19 | 9.86 | 5 | 140895 | 39 | 56151128 |
Fall | 14.14 | 9.86 | 1058 | 139842 | 356452 | 55794715 |
Biliary dyskinesia | 14.08 | 9.86 | 24 | 140876 | 2539 | 56148628 |
Increased appetite | 14.06 | 9.86 | 51 | 140849 | 8684 | 56142483 |
Grip strength decreased | 14.04 | 9.86 | 12 | 140888 | 16244 | 56134923 |
Feeling drunk | 14.02 | 9.86 | 30 | 140870 | 3762 | 56147405 |
Negative thoughts | 14.02 | 9.86 | 14 | 140886 | 872 | 56150295 |
Confabulation | 14.00 | 9.86 | 9 | 140891 | 295 | 56150872 |
Basilar migraine | 13.97 | 9.86 | 5 | 140895 | 41 | 56151126 |
Social anxiety disorder | 13.79 | 9.86 | 10 | 140890 | 400 | 56150767 |
Sudden cardiac death | 13.69 | 9.86 | 21 | 140879 | 2033 | 56149134 |
Hypouricaemia | 13.68 | 9.86 | 7 | 140893 | 147 | 56151020 |
Anal incontinence | 13.63 | 9.86 | 64 | 140836 | 12234 | 56138933 |
Foetal monitoring abnormal | 13.63 | 9.86 | 8 | 140892 | 222 | 56150945 |
Dermatillomania | 13.60 | 9.86 | 7 | 140893 | 149 | 56151018 |
Post-traumatic stress disorder | 13.56 | 9.86 | 33 | 140867 | 4505 | 56146662 |
Ventricular arrhythmia | 13.55 | 9.86 | 28 | 140872 | 3426 | 56147741 |
Therapeutic response decreased | 13.53 | 9.86 | 77 | 140823 | 52681 | 56098486 |
Coordination abnormal | 13.49 | 9.86 | 65 | 140835 | 12556 | 56138611 |
Floppy infant | 13.49 | 9.86 | 6 | 140894 | 91 | 56151076 |
Pericardial effusion | 13.47 | 9.86 | 30 | 140870 | 27145 | 56124022 |
Panniculitis | 13.37 | 9.86 | 4 | 140896 | 9838 | 56141329 |
Palmar-plantar erythrodysaesthesia syndrome | 13.34 | 9.86 | 20 | 140880 | 21045 | 56130122 |
Fluid retention | 13.30 | 9.86 | 80 | 140820 | 53998 | 56097169 |
Electrocardiogram repolarisation abnormality | 13.27 | 9.86 | 16 | 140884 | 1231 | 56149936 |
Panic disorder | 13.26 | 9.86 | 23 | 140877 | 2468 | 56148699 |
Amenorrhoea | 13.25 | 9.86 | 51 | 140849 | 8935 | 56142232 |
Amaurosis | 13.17 | 9.86 | 11 | 140889 | 543 | 56150624 |
Device placement issue | 13.14 | 9.86 | 14 | 140886 | 941 | 56150226 |
Osteoarthritis | 13.09 | 9.86 | 133 | 140767 | 80163 | 56071004 |
Pulmonary vasculitis | 13.09 | 9.86 | 6 | 140894 | 98 | 56151069 |
Neonatal disorder | 13.03 | 9.86 | 11 | 140889 | 551 | 56150616 |
Oesophageal adenocarcinoma | 13.03 | 9.86 | 7 | 140893 | 163 | 56151004 |
Jaw clicking | 13.02 | 9.86 | 4 | 140896 | 19 | 56151148 |
Depersonalisation/derealisation disorder | 12.95 | 9.86 | 16 | 140884 | 1263 | 56149904 |
Drug use disorder | 12.94 | 9.86 | 33 | 140867 | 4636 | 56146531 |
Pregnancy with advanced maternal age | 12.91 | 9.86 | 3 | 140897 | 3 | 56151164 |
Craniosynostosis | 12.88 | 9.86 | 7 | 140893 | 167 | 56151000 |
Platelet dysfunction | 12.87 | 9.86 | 6 | 140894 | 102 | 56151065 |
Metastases to bone | 12.87 | 9.86 | 18 | 140882 | 19490 | 56131677 |
Single umbilical artery | 12.78 | 9.86 | 8 | 140892 | 250 | 56150917 |
Peritonitis | 12.77 | 9.86 | 13 | 140887 | 16189 | 56134978 |
Loss of bladder sensation | 12.76 | 9.86 | 5 | 140895 | 54 | 56151113 |
Fear of weight gain | 12.69 | 9.86 | 4 | 140896 | 21 | 56151146 |
General physical condition abnormal | 12.62 | 9.86 | 29 | 140871 | 3814 | 56147353 |
Leukopenia | 12.62 | 9.86 | 115 | 140785 | 70825 | 56080342 |
Potentiating drug interaction | 12.61 | 9.86 | 30 | 140870 | 4036 | 56147131 |
Duodenal ulcer repair | 12.60 | 9.86 | 5 | 140895 | 56 | 56151111 |
Blood pressure diastolic decreased | 12.58 | 9.86 | 18 | 140882 | 19305 | 56131862 |
Bradycardia neonatal | 12.57 | 9.86 | 13 | 140887 | 844 | 56150323 |
Substance abuse | 12.56 | 9.86 | 32 | 140868 | 4493 | 56146674 |
Adverse event | 12.55 | 9.86 | 84 | 140816 | 55292 | 56095875 |
Pleurothotonus | 12.53 | 9.86 | 16 | 140884 | 1305 | 56149862 |
Sensation of blood flow | 12.52 | 9.86 | 5 | 140895 | 57 | 56151110 |
Vertigo | 12.49 | 9.86 | 199 | 140701 | 54373 | 56096794 |
Thrombotic microangiopathy | 12.47 | 9.86 | 4 | 140896 | 9407 | 56141760 |
Bursitis | 12.44 | 9.86 | 32 | 140868 | 27550 | 56123617 |
Accidental exposure to product | 12.39 | 9.86 | 27 | 140873 | 24620 | 56126547 |
Hospitalisation | 12.32 | 9.86 | 124 | 140776 | 74876 | 56076291 |
Tenosynovitis | 12.31 | 9.86 | 8 | 140892 | 12453 | 56138714 |
Ventricular septal defect | 12.26 | 9.86 | 30 | 140870 | 4108 | 56147059 |
Social avoidant behaviour | 12.24 | 9.86 | 24 | 140876 | 2828 | 56148339 |
Infantile vomiting | 12.22 | 9.86 | 6 | 140894 | 115 | 56151052 |
Unmasking of previously unidentified disease | 12.16 | 9.86 | 13 | 140887 | 877 | 56150290 |
Haematotoxicity | 12.15 | 9.86 | 3 | 140897 | 8380 | 56142787 |
Brucellosis | 12.14 | 9.86 | 5 | 140895 | 62 | 56151105 |
Hyperkalaemia | 12.11 | 9.86 | 76 | 140824 | 50789 | 56100378 |
Areflexia | 12.11 | 9.86 | 24 | 140876 | 2851 | 56148316 |
Hepatic function abnormal | 12.10 | 9.86 | 45 | 140855 | 34513 | 56116654 |
Gambling disorder | 12.02 | 9.86 | 15 | 140885 | 1196 | 56149971 |
Economic problem | 11.99 | 9.86 | 19 | 140881 | 1892 | 56149275 |
Musculoskeletal stiffness | 11.97 | 9.86 | 298 | 140602 | 155709 | 55995458 |
Product use in unapproved indication | 11.91 | 9.86 | 265 | 140635 | 140557 | 56010610 |
Blood magnesium decreased | 11.87 | 9.86 | 60 | 140840 | 11814 | 56139353 |
Premature labour | 11.85 | 9.86 | 60 | 140840 | 11822 | 56139345 |
Medical diet | 11.85 | 9.86 | 4 | 140896 | 27 | 56151140 |
Transplant rejection | 11.85 | 9.86 | 5 | 140895 | 9929 | 56141238 |
Device related infection | 11.82 | 9.86 | 23 | 140877 | 21857 | 56129310 |
Swollen tongue | 11.81 | 9.86 | 122 | 140778 | 30202 | 56120965 |
Condition aggravated | 11.79 | 9.86 | 725 | 140175 | 344173 | 55806994 |
Menstruation irregular | 11.74 | 9.86 | 39 | 140861 | 6357 | 56144810 |
Prescribed underdose | 11.73 | 9.86 | 21 | 140879 | 20596 | 56130571 |
Carotid arterial embolus | 11.70 | 9.86 | 3 | 140897 | 6 | 56151161 |
Hyperinsulinism | 11.70 | 9.86 | 3 | 140897 | 6 | 56151161 |
Renal adenoma | 11.70 | 9.86 | 3 | 140897 | 6 | 56151161 |
Vision blurred | 11.69 | 9.86 | 281 | 140619 | 82662 | 56068505 |
Joint hyperextension | 11.61 | 9.86 | 8 | 140892 | 295 | 56150872 |
Pulmonary fibrosis | 11.60 | 9.86 | 37 | 140863 | 29721 | 56121446 |
Antidepressant drug level above therapeutic | 11.51 | 9.86 | 9 | 140891 | 404 | 56150763 |
Ketonuria | 11.49 | 9.86 | 10 | 140890 | 522 | 56150645 |
Cytopenia | 11.49 | 9.86 | 5 | 140895 | 9750 | 56141417 |
Lip dry | 11.46 | 9.86 | 5 | 140895 | 9735 | 56141432 |
Multiple allergies | 11.41 | 9.86 | 6 | 140894 | 10490 | 56140677 |
Spina bifida occulta | 11.38 | 9.86 | 3 | 140897 | 7 | 56151160 |
Autonomic nervous system imbalance | 11.35 | 9.86 | 22 | 140878 | 2571 | 56148596 |
Pulmonary valve incompetence | 11.32 | 9.86 | 15 | 140885 | 1269 | 56149898 |
Hypertonic bladder | 11.30 | 9.86 | 25 | 140875 | 3207 | 56147960 |
Acute stress disorder | 11.29 | 9.86 | 7 | 140893 | 215 | 56150952 |
Hypometabolism | 11.26 | 9.86 | 4 | 140896 | 32 | 56151135 |
Periodic limb movement disorder | 11.26 | 9.86 | 7 | 140893 | 216 | 56150951 |
Dysmorphism | 11.22 | 9.86 | 20 | 140880 | 2193 | 56148974 |
Status migrainosus | 11.20 | 9.86 | 6 | 140894 | 139 | 56151028 |
Hypnagogic hallucination | 11.16 | 9.86 | 6 | 140894 | 140 | 56151027 |
Death of relative | 11.12 | 9.86 | 7 | 140893 | 221 | 56150946 |
Dissociative identity disorder | 11.11 | 9.86 | 5 | 140895 | 78 | 56151089 |
Diverticulitis | 11.10 | 9.86 | 49 | 140851 | 35803 | 56115364 |
Apgar score low | 11.09 | 9.86 | 11 | 140889 | 679 | 56150488 |
Spasmodic dysphonia | 11.06 | 9.86 | 5 | 140895 | 79 | 56151088 |
Congenital multiplex arthrogryposis | 11.05 | 9.86 | 4 | 140896 | 34 | 56151133 |
Pregnancy on oral contraceptive | 11.04 | 9.86 | 13 | 140887 | 976 | 56150191 |
Pleural disorder | 11.02 | 9.86 | 10 | 140890 | 552 | 56150615 |
Pulmonary arterial hypertension | 11.01 | 9.86 | 32 | 140868 | 26471 | 56124696 |
Macular degeneration | 10.99 | 9.86 | 19 | 140881 | 18889 | 56132278 |
Blood triglycerides increased | 10.98 | 9.86 | 58 | 140842 | 11619 | 56139548 |
Postural tremor | 10.98 | 9.86 | 7 | 140893 | 226 | 56150941 |
Lymphocytic hypophysitis | 10.98 | 9.86 | 7 | 140893 | 226 | 56150941 |
Sleep attacks | 10.89 | 9.86 | 5 | 140895 | 82 | 56151085 |
Oedema peripheral | 10.86 | 9.86 | 336 | 140564 | 170918 | 55980249 |
Thought insertion | 10.84 | 9.86 | 3 | 140897 | 9 | 56151158 |
Tooth demineralisation | 10.84 | 9.86 | 3 | 140897 | 9 | 56151158 |
Irregular breathing | 10.84 | 9.86 | 8 | 140892 | 329 | 56150838 |
Personality disorder | 10.82 | 9.86 | 33 | 140867 | 5140 | 56146027 |
Proteinuria | 10.82 | 9.86 | 17 | 140883 | 17553 | 56133614 |
Gingival discomfort | 10.82 | 9.86 | 7 | 140893 | 232 | 56150935 |
Complication of device insertion | 10.76 | 9.86 | 38 | 140862 | 6386 | 56144781 |
Trismus | 10.76 | 9.86 | 26 | 140874 | 3532 | 56147635 |
Respiratory disorder | 10.76 | 9.86 | 46 | 140854 | 33911 | 56117256 |
Treatment noncompliance | 10.76 | 9.86 | 127 | 140773 | 32496 | 56118671 |
Muscle neoplasm | 10.76 | 9.86 | 4 | 140896 | 37 | 56151130 |
Extensor plantar response | 10.74 | 9.86 | 14 | 140886 | 1166 | 56150001 |
Bacteraemia | 10.74 | 9.86 | 14 | 140886 | 15617 | 56135550 |
Blood pressure diastolic abnormal | 10.72 | 9.86 | 8 | 140892 | 11590 | 56139577 |
Cytokine release syndrome | 10.72 | 9.86 | 7 | 140893 | 10868 | 56140299 |
Blood bilirubin increased | 10.68 | 9.86 | 45 | 140855 | 33309 | 56117858 |
Neonatal respiratory distress | 10.67 | 9.86 | 8 | 140892 | 337 | 56150830 |
Superior mesenteric artery syndrome | 10.67 | 9.86 | 5 | 140895 | 86 | 56151081 |
Back pain | 10.65 | 9.86 | 485 | 140415 | 236685 | 55914482 |
Pulmonary artery stenosis congenital | 10.63 | 9.86 | 7 | 140893 | 239 | 56150928 |
Aspiration | 10.61 | 9.86 | 50 | 140850 | 9571 | 56141596 |
Peripheral venous disease | 10.61 | 9.86 | 6 | 140894 | 10073 | 56141094 |
Antisocial personality disorder | 10.60 | 9.86 | 3 | 140897 | 10 | 56151157 |
Joint effusion | 10.59 | 9.86 | 13 | 140887 | 14885 | 56136282 |
Apnoea | 10.59 | 9.86 | 41 | 140859 | 7201 | 56143966 |
Gallbladder neoplasm | 10.57 | 9.86 | 4 | 140896 | 39 | 56151128 |
Dermatitis atopic | 10.56 | 9.86 | 45 | 140855 | 8254 | 56142913 |
Premature rupture of membranes | 10.54 | 9.86 | 31 | 140869 | 4734 | 56146433 |
Oedema | 10.52 | 9.86 | 143 | 140757 | 81777 | 56069390 |
Pelvic pain | 10.52 | 9.86 | 58 | 140842 | 11809 | 56139358 |
Lymphatic system neoplasm | 10.48 | 9.86 | 4 | 140896 | 40 | 56151127 |
Job dissatisfaction | 10.39 | 9.86 | 4 | 140896 | 41 | 56151126 |
Lactation disorder | 10.35 | 9.86 | 8 | 140892 | 353 | 56150814 |
Blood parathyroid hormone decreased | 10.32 | 9.86 | 4 | 140896 | 8360 | 56142807 |
Pyloric stenosis | 10.27 | 9.86 | 8 | 140892 | 357 | 56150810 |
Brain injury | 10.14 | 9.86 | 37 | 140863 | 6318 | 56144849 |
Pulmonary embolism | 10.12 | 9.86 | 345 | 140555 | 106779 | 56044388 |
Derealisation | 10.11 | 9.86 | 13 | 140887 | 1068 | 56150099 |
Basal cell carcinoma | 10.09 | 9.86 | 31 | 140869 | 25190 | 56125977 |
Verbal abuse | 10.08 | 9.86 | 5 | 140895 | 98 | 56151069 |
Skin disorder | 10.06 | 9.86 | 33 | 140867 | 26276 | 56124891 |
Middle insomnia | 10.03 | 9.86 | 54 | 140846 | 10896 | 56140271 |
Neutropenic sepsis | 10.03 | 9.86 | 14 | 140886 | 15171 | 56135996 |
Embolism | 9.99 | 9.86 | 3 | 140897 | 7361 | 56143806 |
Rhabdomyolysis | 9.97 | 9.86 | 150 | 140750 | 40508 | 56110659 |
Ataxia | 9.97 | 9.86 | 66 | 140834 | 14337 | 56136830 |
Micturition urgency | 9.96 | 9.86 | 46 | 140854 | 8735 | 56142432 |
Menstruation normal | 9.95 | 9.86 | 6 | 140894 | 175 | 56150992 |
Skin infection | 9.94 | 9.86 | 11 | 140889 | 13184 | 56137983 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Serotonin syndrome | 945.80 | 10.99 | 533 | 59727 | 18240 | 31618844 |
Suicidal ideation | 449.76 | 10.99 | 443 | 59817 | 35963 | 31601121 |
Completed suicide | 394.59 | 10.99 | 659 | 59601 | 90855 | 31546229 |
Toxicity to various agents | 369.54 | 10.99 | 959 | 59301 | 180528 | 31456556 |
Suicide attempt | 348.76 | 10.99 | 391 | 59869 | 36857 | 31600227 |
Obsessive-compulsive disorder | 334.93 | 10.99 | 171 | 60089 | 4766 | 31632318 |
Intentional overdose | 316.98 | 10.99 | 392 | 59868 | 40997 | 31596087 |
Drug interaction | 289.00 | 10.99 | 961 | 59299 | 207582 | 31429502 |
Depression | 230.32 | 10.99 | 523 | 59737 | 90292 | 31546792 |
Akathisia | 229.16 | 10.99 | 153 | 60107 | 7100 | 31629984 |
Anxiety | 218.46 | 10.99 | 513 | 59747 | 90520 | 31546564 |
Aggression | 182.80 | 10.99 | 285 | 59975 | 37006 | 31600078 |
Agitation | 170.75 | 10.99 | 341 | 59919 | 53828 | 31583256 |
Euphoric mood | 165.64 | 10.99 | 108 | 60152 | 4812 | 31632272 |
Drug abuse | 162.02 | 10.99 | 448 | 59812 | 87310 | 31549774 |
Overdose | 147.25 | 10.99 | 423 | 59837 | 84241 | 31552843 |
Antipsychotic drug level below therapeutic | 146.03 | 10.99 | 73 | 60187 | 1942 | 31635142 |
Therapeutic product effect variable | 136.89 | 10.99 | 69 | 60191 | 1869 | 31635215 |
Drug withdrawal syndrome | 132.93 | 10.99 | 171 | 60089 | 18579 | 31618505 |
Disinhibition | 128.81 | 10.99 | 74 | 60186 | 2619 | 31634465 |
Homicide | 125.51 | 10.99 | 52 | 60208 | 880 | 31636204 |
Febrile neutropenia | 116.53 | 10.99 | 43 | 60217 | 121806 | 31515278 |
Increased appetite | 113.19 | 10.99 | 95 | 60165 | 6249 | 31630835 |
Irritability | 93.27 | 10.99 | 161 | 60099 | 22728 | 31614356 |
Depressed mood | 92.66 | 10.99 | 139 | 60121 | 17436 | 31619648 |
Psychotic disorder | 92.40 | 10.99 | 158 | 60102 | 22135 | 31614949 |
Electrocardiogram QT prolonged | 91.94 | 10.99 | 215 | 60045 | 37772 | 31599312 |
Pneumonia | 89.66 | 10.99 | 332 | 59928 | 334980 | 31302104 |
Drug dependence | 89.63 | 10.99 | 157 | 60103 | 22422 | 31614662 |
Tardive dyskinesia | 84.54 | 10.99 | 76 | 60184 | 5483 | 31631601 |
Obesity | 83.04 | 10.99 | 104 | 60156 | 10996 | 31626088 |
Pyrexia | 80.42 | 10.99 | 302 | 59958 | 303538 | 31333546 |
Anaemia | 79.97 | 10.99 | 180 | 60080 | 213342 | 31423742 |
Paranoia | 77.54 | 10.99 | 98 | 60162 | 10457 | 31626627 |
Malignant neoplasm progression | 76.98 | 10.99 | 27 | 60233 | 78971 | 31558113 |
Sepsis | 76.86 | 10.99 | 106 | 60154 | 151823 | 31485261 |
Mania | 76.80 | 10.99 | 91 | 60169 | 9086 | 31627998 |
Exposure during pregnancy | 76.53 | 10.99 | 88 | 60172 | 8510 | 31628574 |
Sedation | 72.85 | 10.99 | 130 | 60130 | 18835 | 31618249 |
Poisoning | 70.88 | 10.99 | 93 | 60167 | 10298 | 31626786 |
Intentional self-injury | 69.74 | 10.99 | 105 | 60155 | 13210 | 31623874 |
Suicidal behaviour | 67.55 | 10.99 | 39 | 60221 | 1393 | 31635691 |
Intentional product misuse | 63.35 | 10.99 | 187 | 60073 | 37764 | 31599320 |
Hyperreflexia | 62.85 | 10.99 | 49 | 60211 | 2900 | 31634184 |
Tremor | 62.29 | 10.99 | 299 | 59961 | 76121 | 31560963 |
Thrombocytopenia | 62.26 | 10.99 | 110 | 60150 | 142637 | 31494447 |
Victim of child abuse | 60.14 | 10.99 | 31 | 60229 | 881 | 31636203 |
Platelet count decreased | 59.99 | 10.99 | 73 | 60187 | 110362 | 31526722 |
Anger | 58.48 | 10.99 | 88 | 60172 | 11065 | 31626019 |
Drug withdrawal syndrome neonatal | 57.61 | 10.99 | 50 | 60210 | 3442 | 31633642 |
Muscle twitching | 56.66 | 10.99 | 74 | 60186 | 8156 | 31628928 |
Weight increased | 56.07 | 10.99 | 308 | 59952 | 82639 | 31554445 |
Abnormal behaviour | 55.61 | 10.99 | 133 | 60127 | 23695 | 31613389 |
Disease progression | 55.54 | 10.99 | 54 | 60206 | 90410 | 31546674 |
Homicidal ideation | 55.11 | 10.99 | 43 | 60217 | 2548 | 31634536 |
Extrapyramidal disorder | 54.87 | 10.99 | 88 | 60172 | 11690 | 31625394 |
Tic | 54.67 | 10.99 | 38 | 60222 | 1883 | 31635201 |
Sexual dysfunction | 54.66 | 10.99 | 62 | 60198 | 5906 | 31631178 |
General physical health deterioration | 53.55 | 10.99 | 83 | 60177 | 113352 | 31523732 |
Social avoidant behaviour | 53.50 | 10.99 | 45 | 60215 | 2968 | 31634116 |
Affective disorder | 52.75 | 10.99 | 49 | 60211 | 3687 | 31633397 |
Dyskinesia | 51.28 | 10.99 | 119 | 60141 | 20791 | 31616293 |
Diarrhoea | 50.22 | 10.99 | 429 | 59831 | 351980 | 31285104 |
Disturbance in attention | 49.92 | 10.99 | 123 | 60137 | 22327 | 31614757 |
Rheumatoid arthritis | 48.91 | 10.99 | 15 | 60245 | 47794 | 31589290 |
Insomnia | 47.56 | 10.99 | 326 | 59934 | 94510 | 31542574 |
Parasomnia | 47.55 | 10.99 | 20 | 60240 | 352 | 31636732 |
Synaesthesia | 47.41 | 10.99 | 9 | 60251 | 0 | 31637084 |
Hallucination, auditory | 46.35 | 10.99 | 76 | 60184 | 10284 | 31626800 |
Mental disorder | 45.83 | 10.99 | 89 | 60171 | 13745 | 31623339 |
Obsessive-compulsive symptom | 45.64 | 10.99 | 15 | 60245 | 126 | 31636958 |
Asphyxia | 44.80 | 10.99 | 55 | 60205 | 5696 | 31631388 |
Haemoglobin decreased | 44.58 | 10.99 | 92 | 60168 | 112583 | 31524501 |
Antipsychotic drug level increased | 44.34 | 10.99 | 43 | 60217 | 3415 | 31633669 |
Torsade de pointes | 43.18 | 10.99 | 59 | 60201 | 6791 | 31630293 |
Pancytopenia | 43.03 | 10.99 | 62 | 60198 | 87254 | 31549830 |
Renal impairment | 42.86 | 10.99 | 61 | 60199 | 86288 | 31550796 |
Myoclonus | 42.73 | 10.99 | 87 | 60173 | 13903 | 31623181 |
Withdrawal syndrome | 42.05 | 10.99 | 78 | 60182 | 11639 | 31625445 |
Bipolar disorder | 41.66 | 10.99 | 43 | 60217 | 3681 | 31633403 |
Nightmare | 41.33 | 10.99 | 79 | 60181 | 12058 | 31625026 |
Visceral congestion | 40.67 | 10.99 | 20 | 60240 | 513 | 31636571 |
Panic attack | 40.50 | 10.99 | 65 | 60195 | 8638 | 31628446 |
Major depression | 40.34 | 10.99 | 45 | 60215 | 4208 | 31632876 |
Drug abuser | 40.19 | 10.99 | 43 | 60217 | 3837 | 31633247 |
Rash | 40.17 | 10.99 | 222 | 60038 | 201264 | 31435820 |
Atrial fibrillation | 40.05 | 10.99 | 99 | 60161 | 113684 | 31523400 |
Tremor neonatal | 40.02 | 10.99 | 18 | 60242 | 375 | 31636709 |
Generalised tonic-clonic seizure | 39.95 | 10.99 | 105 | 60155 | 19826 | 31617258 |
Infection | 39.56 | 10.99 | 59 | 60201 | 81872 | 31555212 |
Depersonalisation/derealisation disorder | 38.87 | 10.99 | 20 | 60240 | 566 | 31636518 |
Hepatic function abnormal | 38.60 | 10.99 | 15 | 60245 | 41207 | 31595877 |
Respiratory depression | 38.27 | 10.99 | 85 | 60175 | 14425 | 31622659 |
Neutropenia | 36.68 | 10.99 | 140 | 60120 | 140224 | 31496860 |
Prescribed overdose | 36.57 | 10.99 | 64 | 60196 | 9128 | 31627956 |
Maternal drugs affecting foetus | 36.51 | 10.99 | 41 | 60219 | 3862 | 31633222 |
Chorea | 36.25 | 10.99 | 23 | 60237 | 977 | 31636107 |
Acute kidney injury | 36.07 | 10.99 | 349 | 59911 | 279365 | 31357719 |
Clonus | 35.49 | 10.99 | 33 | 60227 | 2486 | 31634598 |
Apathy | 35.21 | 10.99 | 52 | 60208 | 6430 | 31630654 |
Hyperhidrosis | 35.16 | 10.99 | 234 | 60026 | 67159 | 31569925 |
Thinking abnormal | 35.13 | 10.99 | 48 | 60212 | 5525 | 31631559 |
Somnolence | 35.01 | 10.99 | 315 | 59945 | 99130 | 31537954 |
Neuroleptic malignant syndrome | 34.97 | 10.99 | 90 | 60170 | 16779 | 31620305 |
Mucosal inflammation | 34.86 | 10.99 | 11 | 60249 | 34416 | 31602668 |
Blood prolactin increased | 34.64 | 10.99 | 27 | 60233 | 1597 | 31635487 |
Mast cell activation syndrome | 33.88 | 10.99 | 13 | 60247 | 178 | 31636906 |
Abnormal sleep-related event | 33.87 | 10.99 | 17 | 60243 | 456 | 31636628 |
Delusion | 33.60 | 10.99 | 72 | 60188 | 11925 | 31625159 |
Rhabdomyolysis | 33.31 | 10.99 | 221 | 60039 | 63360 | 31573724 |
Seizure | 33.08 | 10.99 | 312 | 59948 | 99456 | 31537628 |
Dyslipidaemia | 32.81 | 10.99 | 50 | 60210 | 6356 | 31630728 |
Stomatitis | 32.78 | 10.99 | 17 | 60243 | 39421 | 31597663 |
Mood swings | 32.59 | 10.99 | 54 | 60206 | 7370 | 31629714 |
Priapism | 32.52 | 10.99 | 42 | 60218 | 4578 | 31632506 |
Product complaint | 32.46 | 10.99 | 46 | 60214 | 5478 | 31631606 |
Hallucination | 32.46 | 10.99 | 174 | 60086 | 46236 | 31590848 |
Drug level increased | 32.28 | 10.99 | 98 | 60162 | 20088 | 31616996 |
Poisoning deliberate | 31.68 | 10.99 | 53 | 60207 | 7291 | 31629793 |
Nervousness | 30.98 | 10.99 | 69 | 60191 | 11731 | 31625353 |
Oral discharge | 30.92 | 10.99 | 11 | 60249 | 120 | 31636964 |
Cytomegalovirus infection | 30.79 | 10.99 | 5 | 60255 | 24702 | 31612382 |
Choreoathetosis | 30.73 | 10.99 | 21 | 60239 | 1012 | 31636072 |
Sleep disorder | 30.70 | 10.99 | 115 | 60145 | 26233 | 31610851 |
Abnormal dreams | 30.26 | 10.99 | 51 | 60209 | 7057 | 31630027 |
Memory impairment | 30.18 | 10.99 | 148 | 60112 | 37982 | 31599102 |
Septic shock | 29.70 | 10.99 | 50 | 60210 | 66108 | 31570976 |
Restless legs syndrome | 29.57 | 10.99 | 53 | 60207 | 7703 | 31629381 |
Persistent foetal circulation | 29.51 | 10.99 | 14 | 60246 | 331 | 31636753 |
Social anxiety disorder | 29.12 | 10.99 | 13 | 60247 | 266 | 31636818 |
Tearfulness | 28.62 | 10.99 | 26 | 60234 | 1901 | 31635183 |
Psychomotor hyperactivity | 28.46 | 10.99 | 56 | 60204 | 8731 | 31628353 |
Child abuse | 28.40 | 10.99 | 14 | 60246 | 361 | 31636723 |
Dissociation | 28.39 | 10.99 | 22 | 60238 | 1290 | 31635794 |
Epidural lipomatosis | 28.34 | 10.99 | 18 | 60242 | 766 | 31636318 |
Bruxism | 28.23 | 10.99 | 24 | 60236 | 1606 | 31635478 |
Serum ferritin abnormal | 28.08 | 10.99 | 12 | 60248 | 220 | 31636864 |
Interstitial lung disease | 27.94 | 10.99 | 46 | 60214 | 61357 | 31575727 |
Huntington's disease | 27.88 | 10.99 | 8 | 60252 | 40 | 31637044 |
Derealisation | 27.78 | 10.99 | 16 | 60244 | 569 | 31636515 |
Impulsive behaviour | 27.65 | 10.99 | 26 | 60234 | 1987 | 31635097 |
Libido decreased | 27.65 | 10.99 | 38 | 60222 | 4398 | 31632686 |
Muscle rigidity | 27.26 | 10.99 | 59 | 60201 | 9838 | 31627246 |
Antidepressant drug level increased | 27.18 | 10.99 | 10 | 60250 | 121 | 31636963 |
Congenital aortic valve stenosis | 27.18 | 10.99 | 10 | 60250 | 121 | 31636963 |
Off label use | 26.83 | 10.99 | 482 | 59778 | 346792 | 31290292 |
Coma | 26.58 | 10.99 | 151 | 60109 | 40999 | 31596085 |
Cardiac failure | 26.33 | 10.99 | 80 | 60180 | 85873 | 31551211 |
Prostate cancer | 26.03 | 10.99 | 20 | 60240 | 37581 | 31599503 |
Accidental death | 25.53 | 10.99 | 26 | 60234 | 2191 | 31634893 |
Cyanosis neonatal | 25.48 | 10.99 | 12 | 60248 | 279 | 31636805 |
Neonatal disorder | 25.44 | 10.99 | 17 | 60243 | 789 | 31636295 |
Cardiac arrest | 25.40 | 10.99 | 270 | 59990 | 88792 | 31548292 |
Accommodation disorder | 25.29 | 10.99 | 11 | 60249 | 211 | 31636873 |
Renal failure | 25.02 | 10.99 | 135 | 60125 | 123195 | 31513889 |
Initial insomnia | 24.59 | 10.99 | 29 | 60231 | 2880 | 31634204 |
Product substitution issue | 24.59 | 10.99 | 55 | 60205 | 9377 | 31627707 |
Gambling disorder | 24.55 | 10.99 | 22 | 60238 | 1580 | 31635504 |
Foetal exposure during pregnancy | 24.46 | 10.99 | 147 | 60113 | 40729 | 31596355 |
Oculogyric crisis | 24.34 | 10.99 | 21 | 60239 | 1434 | 31635650 |
Pulmonary embolism | 24.29 | 10.99 | 77 | 60183 | 81569 | 31555515 |
Alcohol poisoning | 24.18 | 10.99 | 30 | 60230 | 3141 | 31633943 |
Dreamy state | 24.12 | 10.99 | 6 | 60254 | 15 | 31637069 |
Violence-related symptom | 24.05 | 10.99 | 14 | 60246 | 508 | 31636576 |
Antisocial behaviour | 24.04 | 10.99 | 12 | 60248 | 318 | 31636766 |
Obsessive thoughts | 23.83 | 10.99 | 15 | 60245 | 628 | 31636456 |
Herpes zoster | 23.47 | 10.99 | 16 | 60244 | 31977 | 31605107 |
Hyperkalaemia | 23.41 | 10.99 | 55 | 60205 | 64296 | 31572788 |
Plasma cell myeloma | 23.33 | 10.99 | 45 | 60215 | 56486 | 31580598 |
Mood altered | 23.27 | 10.99 | 50 | 60210 | 8296 | 31628788 |
Restlessness | 23.21 | 10.99 | 97 | 60163 | 23264 | 31613820 |
Compulsions | 23.17 | 10.99 | 10 | 60250 | 188 | 31636896 |
Lethargy | 23.14 | 10.99 | 139 | 60121 | 38502 | 31598582 |
Tourette's disorder | 23.11 | 10.99 | 8 | 60252 | 80 | 31637004 |
Electrocardiogram QRS complex prolonged | 23.07 | 10.99 | 34 | 60226 | 4195 | 31632889 |
Juvenile idiopathic arthritis | 23.07 | 10.99 | 22 | 60238 | 1711 | 31635373 |
Feeling jittery | 23.01 | 10.99 | 32 | 60228 | 3745 | 31633339 |
Hostility | 22.87 | 10.99 | 16 | 60244 | 801 | 31636283 |
Pleural effusion | 22.75 | 10.99 | 70 | 60190 | 74850 | 31562234 |
Neuropathy peripheral | 22.75 | 10.99 | 71 | 60189 | 75578 | 31561506 |
Parkinsonism | 22.74 | 10.99 | 47 | 60213 | 7589 | 31629495 |
Schizoaffective disorder | 22.55 | 10.99 | 19 | 60241 | 1256 | 31635828 |
Eye movement disorder | 22.46 | 10.99 | 32 | 60228 | 3829 | 31633255 |
Neonatal respiratory distress syndrome | 22.31 | 10.99 | 32 | 60228 | 3853 | 31633231 |
Bone marrow failure | 21.93 | 10.99 | 13 | 60247 | 27995 | 31609089 |
Disseminated intravascular coagulation | 21.82 | 10.99 | 6 | 60254 | 20531 | 31616553 |
Emotional disorder | 21.47 | 10.99 | 37 | 60223 | 5212 | 31631872 |
Vasoplegia syndrome | 21.40 | 10.99 | 21 | 60239 | 1692 | 31635392 |
Serum serotonin decreased | 21.07 | 10.99 | 4 | 60256 | 0 | 31637084 |
Treatment failure | 21.05 | 10.99 | 28 | 60232 | 40764 | 31596320 |
Hyperdynamic left ventricle | 21.01 | 10.99 | 9 | 60251 | 166 | 31636918 |
Alcoholism | 21.01 | 10.99 | 29 | 60231 | 3370 | 31633714 |
Blunted affect | 20.95 | 10.99 | 11 | 60249 | 325 | 31636759 |
Respiratory arrest | 20.83 | 10.99 | 102 | 60158 | 26155 | 31610929 |
Porphyria acute | 20.82 | 10.99 | 11 | 60249 | 329 | 31636755 |
Flat affect | 20.80 | 10.99 | 15 | 60245 | 788 | 31636296 |
Vascular stenosis | 20.63 | 10.99 | 9 | 60251 | 174 | 31636910 |
Mydriasis | 20.31 | 10.99 | 41 | 60219 | 6511 | 31630573 |
Ascites | 20.31 | 10.99 | 29 | 60231 | 40984 | 31596100 |
Poor quality sleep | 20.27 | 10.99 | 45 | 60215 | 7633 | 31629451 |
Selective mutism | 20.22 | 10.99 | 7 | 60253 | 70 | 31637014 |
Infusion related reaction | 20.05 | 10.99 | 38 | 60222 | 48017 | 31589067 |
Leukaemia | 20.03 | 10.99 | 31 | 60229 | 3994 | 31633090 |
Myocardial infarction | 19.93 | 10.99 | 130 | 60130 | 113324 | 31523760 |
Erythema | 19.83 | 10.99 | 82 | 60178 | 80323 | 31556761 |
White blood cell count decreased | 19.82 | 10.99 | 92 | 60168 | 87306 | 31549778 |
Hypersomnia | 19.71 | 10.99 | 56 | 60204 | 11063 | 31626021 |
Loss of employment | 19.65 | 10.99 | 12 | 60248 | 476 | 31636608 |
Dystonia | 19.61 | 10.99 | 53 | 60207 | 10172 | 31626912 |
Premature baby | 19.53 | 10.99 | 77 | 60183 | 17989 | 31619095 |
Peripheral swelling | 19.49 | 10.99 | 65 | 60195 | 67800 | 31569284 |
Cholinergic syndrome | 19.38 | 10.99 | 12 | 60248 | 488 | 31636596 |
Pain | 19.26 | 10.99 | 245 | 60015 | 186514 | 31450570 |
Tachyphrenia | 19.22 | 10.99 | 17 | 60243 | 1200 | 31635884 |
Yawning | 19.20 | 10.99 | 12 | 60248 | 496 | 31636588 |
Compulsive shopping | 19.13 | 10.99 | 11 | 60249 | 390 | 31636694 |
Negative thoughts | 19.03 | 10.99 | 13 | 60247 | 626 | 31636458 |
Arthralgia | 19.01 | 10.99 | 190 | 60070 | 151234 | 31485850 |
Self-injurious ideation | 18.98 | 10.99 | 19 | 60241 | 1568 | 31635516 |
Hypoglycaemia neonatal | 18.90 | 10.99 | 20 | 60240 | 1762 | 31635322 |
Agitation neonatal | 18.87 | 10.99 | 16 | 60244 | 1067 | 31636017 |
Loss of libido | 18.81 | 10.99 | 23 | 60237 | 2372 | 31634712 |
Somnambulism | 18.64 | 10.99 | 25 | 60235 | 2827 | 31634257 |
Congenital aortic valve incompetence | 18.56 | 10.99 | 8 | 60252 | 150 | 31636934 |
Compulsive hoarding | 18.53 | 10.99 | 5 | 60255 | 19 | 31637065 |
Renal ischaemia | 18.51 | 10.99 | 12 | 60248 | 529 | 31636555 |
Hypomania | 18.43 | 10.99 | 22 | 60238 | 2213 | 31634871 |
Retinal phototoxicity | 18.30 | 10.99 | 4 | 60256 | 4 | 31637080 |
COVID-19 | 18.27 | 10.99 | 49 | 60211 | 54772 | 31582312 |
Pneumocystis jirovecii pneumonia | 18.18 | 10.99 | 6 | 60254 | 18245 | 31618839 |
Pituitary tumour benign | 18.13 | 10.99 | 14 | 60246 | 817 | 31636267 |
Small for dates baby | 17.98 | 10.99 | 28 | 60232 | 3627 | 31633457 |
Neoplasm progression | 17.97 | 10.99 | 8 | 60252 | 20264 | 31616820 |
Condition aggravated | 17.92 | 10.99 | 423 | 59837 | 163586 | 31473498 |
Haematochezia | 17.77 | 10.99 | 31 | 60229 | 40433 | 31596651 |
Colitis | 17.75 | 10.99 | 23 | 60237 | 33864 | 31603220 |
Anaphylactic reaction | 17.71 | 10.99 | 18 | 60242 | 29535 | 31607549 |
Dyspnoea | 17.62 | 10.99 | 508 | 59752 | 342971 | 31294113 |
Gastrointestinal haemorrhage | 17.49 | 10.99 | 89 | 60171 | 82460 | 31554624 |
Chronic actinic dermatitis | 17.43 | 10.99 | 5 | 60255 | 25 | 31637059 |
C-reactive protein increased | 17.35 | 10.99 | 42 | 60218 | 48608 | 31588476 |
Tumour lysis syndrome | 17.30 | 10.99 | 4 | 60256 | 15381 | 31621703 |
Urinary tract discomfort | 17.25 | 10.99 | 7 | 60253 | 112 | 31636972 |
Cognitive disorder | 17.12 | 10.99 | 93 | 60167 | 24830 | 31612254 |
Lymphocyte count decreased | 17.01 | 10.99 | 9 | 60251 | 20640 | 31616444 |
Hypersexuality | 17.00 | 10.99 | 17 | 60243 | 1401 | 31635683 |
Cough | 16.98 | 10.99 | 169 | 60091 | 134645 | 31502439 |
Coagulation factor VII level decreased | 16.92 | 10.99 | 7 | 60253 | 118 | 31636966 |
Liver disorder | 16.79 | 10.99 | 19 | 60241 | 29688 | 31607396 |
Physical deconditioning | 16.65 | 10.99 | 14 | 60246 | 923 | 31636161 |
Alcohol use | 16.62 | 10.99 | 25 | 60235 | 3142 | 31633942 |
Secondary hypogonadism | 16.60 | 10.99 | 9 | 60251 | 284 | 31636800 |
Neutrophil count decreased | 16.59 | 10.99 | 40 | 60220 | 46354 | 31590730 |
Hyperprolactinaemia | 16.29 | 10.99 | 17 | 60243 | 1474 | 31635610 |
Joint swelling | 16.16 | 10.99 | 50 | 60210 | 53381 | 31583703 |
Pupil fixed | 16.09 | 10.99 | 18 | 60242 | 1689 | 31635395 |
Renal artery thrombosis | 16.07 | 10.99 | 9 | 60251 | 303 | 31636781 |
Miosis | 16.01 | 10.99 | 44 | 60216 | 8526 | 31628558 |
Multiple organ dysfunction syndrome | 15.93 | 10.99 | 71 | 60189 | 68132 | 31568952 |
Feeling abnormal | 15.86 | 10.99 | 172 | 60088 | 56830 | 31580254 |
Feeling guilty | 15.83 | 10.99 | 9 | 60251 | 312 | 31636772 |
Basilar migraine | 15.80 | 10.99 | 4 | 60256 | 11 | 31637073 |
Dysphoria | 15.68 | 10.99 | 20 | 60240 | 2152 | 31634932 |
Decreased interest | 15.59 | 10.99 | 20 | 60240 | 2165 | 31634919 |
Palmar-plantar erythrodysaesthesia syndrome | 15.58 | 10.99 | 5 | 60255 | 15478 | 31621606 |
Muscle necrosis | 15.55 | 10.99 | 13 | 60247 | 850 | 31636234 |
Erectile dysfunction | 15.45 | 10.99 | 75 | 60185 | 19160 | 31617924 |
Tension | 15.37 | 10.99 | 19 | 60241 | 1982 | 31635102 |
Phobia | 15.34 | 10.99 | 7 | 60253 | 151 | 31636933 |
Dissociative disorder | 15.25 | 10.99 | 8 | 60252 | 236 | 31636848 |
Congenital hand malformation | 15.24 | 10.99 | 11 | 60249 | 579 | 31636505 |
Coma uraemic | 15.21 | 10.99 | 5 | 60255 | 42 | 31637042 |
Exposure via ingestion | 15.18 | 10.99 | 19 | 60241 | 2006 | 31635078 |
Autonomic nervous system imbalance | 15.17 | 10.99 | 21 | 60239 | 2446 | 31634638 |
Transposition of the great vessels | 15.14 | 10.99 | 10 | 60250 | 455 | 31636629 |
Blood cholesterol increased | 15.14 | 10.99 | 68 | 60192 | 16825 | 31620259 |
Hyperbilirubinaemia neonatal | 15.10 | 10.99 | 12 | 60248 | 730 | 31636354 |
Spina bifida | 15.01 | 10.99 | 9 | 60251 | 345 | 31636739 |
Cataplexy | 14.90 | 10.99 | 9 | 60251 | 350 | 31636734 |
Creatinine urine decreased | 14.81 | 10.99 | 5 | 60255 | 46 | 31637038 |
Pyloric stenosis | 14.74 | 10.99 | 12 | 60248 | 756 | 31636328 |
Mutism | 14.66 | 10.99 | 12 | 60248 | 762 | 31636322 |
Respiratory failure | 14.58 | 10.99 | 123 | 60137 | 101326 | 31535758 |
Cerebrovascular stenosis | 14.56 | 10.99 | 6 | 60254 | 100 | 31636984 |
Salivary hypersecretion | 14.55 | 10.99 | 40 | 60220 | 7752 | 31629332 |
Eye colour change | 14.54 | 10.99 | 8 | 60252 | 260 | 31636824 |
Dysphemia | 14.50 | 10.99 | 16 | 60244 | 1478 | 31635606 |
Ear discomfort | 14.49 | 10.99 | 20 | 60240 | 2324 | 31634760 |
Bronchopulmonary aspergillosis | 14.45 | 10.99 | 4 | 60256 | 13630 | 31623454 |
Post 5-alpha-reductase inhibitor syndrome | 14.40 | 10.99 | 6 | 60254 | 103 | 31636981 |
Intentional product use issue | 14.35 | 10.99 | 47 | 60213 | 49300 | 31587784 |
Blood glucose fluctuation | 14.16 | 10.99 | 26 | 60234 | 3849 | 31633235 |
Bipolar I disorder | 14.13 | 10.99 | 12 | 60248 | 802 | 31636282 |
Feeling drunk | 14.05 | 10.99 | 17 | 60243 | 1734 | 31635350 |
Tongue injury | 14.04 | 10.99 | 6 | 60254 | 110 | 31636974 |
Blood luteinising hormone decreased | 13.94 | 10.99 | 6 | 60254 | 112 | 31636972 |
Otosalpingitis | 13.94 | 10.99 | 4 | 60256 | 20 | 31637064 |
Alpha 2 globulin decreased | 13.94 | 10.99 | 4 | 60256 | 20 | 31637064 |
Crying | 13.88 | 10.99 | 32 | 60228 | 5565 | 31631519 |
Disorientation | 13.82 | 10.99 | 103 | 60157 | 30641 | 31606443 |
Sex hormone binding globulin decreased | 13.78 | 10.99 | 4 | 60256 | 21 | 31637063 |
Free androgen index decreased | 13.78 | 10.99 | 4 | 60256 | 21 | 31637063 |
Delayed sleep phase | 13.73 | 10.99 | 3 | 60257 | 3 | 31637081 |
Blood creatine phosphokinase MB | 13.73 | 10.99 | 3 | 60257 | 3 | 31637081 |
Blood creatinine increased | 13.72 | 10.99 | 106 | 60154 | 88972 | 31548112 |
Hypogonadism male | 13.70 | 10.99 | 8 | 60252 | 292 | 31636792 |
Myelodysplastic syndrome | 13.63 | 10.99 | 10 | 60250 | 19241 | 31617843 |
Viral acanthoma | 13.62 | 10.99 | 4 | 60256 | 22 | 31637062 |
Androgen insensitivity syndrome | 13.62 | 10.99 | 4 | 60256 | 22 | 31637062 |
Bone marrow oedema | 13.48 | 10.99 | 10 | 60250 | 549 | 31636535 |
Self-medication | 13.47 | 10.99 | 19 | 60241 | 2252 | 31634832 |
Panic disorder | 13.47 | 10.99 | 14 | 60246 | 1208 | 31635876 |
Tinnitus | 13.47 | 10.99 | 64 | 60196 | 16211 | 31620873 |
Marital problem | 13.34 | 10.99 | 5 | 60255 | 64 | 31637020 |
Pruritus | 13.33 | 10.99 | 163 | 60097 | 125004 | 31512080 |
Testicular microlithiasis | 13.33 | 10.99 | 4 | 60256 | 24 | 31637060 |
Treatment noncompliance | 13.27 | 10.99 | 89 | 60171 | 25595 | 31611489 |
Hypertonia neonatal | 13.24 | 10.99 | 9 | 60251 | 430 | 31636654 |
Urine calcium/creatinine ratio increased | 13.19 | 10.99 | 4 | 60256 | 25 | 31637059 |
Dehydroepiandrosterone decreased | 13.19 | 10.99 | 4 | 60256 | 25 | 31637059 |
Logorrhoea | 13.17 | 10.99 | 19 | 60241 | 2300 | 31634784 |
Confusional state | 13.09 | 10.99 | 339 | 59921 | 132995 | 31504089 |
Suspected suicide | 13.09 | 10.99 | 26 | 60234 | 4081 | 31633003 |
Economic problem | 13.01 | 10.99 | 14 | 60246 | 1257 | 31635827 |
Faecal calprotectin | 12.93 | 10.99 | 4 | 60256 | 27 | 31637057 |
Fear | 12.86 | 10.99 | 45 | 60215 | 9929 | 31627155 |
Blood triglycerides increased | 12.82 | 10.99 | 55 | 60205 | 13342 | 31623742 |
Arnold-Chiari malformation | 12.82 | 10.99 | 8 | 60252 | 330 | 31636754 |
Hypothalamic pituitary adrenal axis suppression | 12.80 | 10.99 | 6 | 60254 | 138 | 31636946 |
Hospitalisation | 12.78 | 10.99 | 50 | 60210 | 49757 | 31587327 |
Oedema | 12.75 | 10.99 | 40 | 60220 | 42521 | 31594563 |
Hepatic failure | 12.66 | 10.99 | 27 | 60233 | 32675 | 31604409 |
Cytokine release syndrome | 12.64 | 10.99 | 8 | 60252 | 16634 | 31620450 |
Blood lactate dehydrogenase increased | 12.63 | 10.99 | 12 | 60248 | 20327 | 31616757 |
Product prescribing error | 12.62 | 10.99 | 72 | 60188 | 19570 | 31617514 |
Testis cancer | 12.62 | 10.99 | 14 | 60246 | 1301 | 31635783 |
Heart rate abnormal | 12.54 | 10.99 | 16 | 60244 | 1722 | 31635362 |
Atrial conduction time prolongation | 12.52 | 10.99 | 3 | 60257 | 6 | 31637078 |
Alpha globulin increased | 12.52 | 10.99 | 3 | 60257 | 6 | 31637078 |
Thrombosis | 12.45 | 10.99 | 44 | 60216 | 45107 | 31591977 |
Atrial septal defect | 12.39 | 10.99 | 35 | 60225 | 6892 | 31630192 |
Retrograde ejaculation | 12.37 | 10.99 | 8 | 60252 | 351 | 31636733 |
Wrong drug | 12.32 | 10.99 | 5 | 60255 | 80 | 31637004 |
Cerebral infarction | 12.24 | 10.99 | 19 | 60241 | 25958 | 31611126 |
Full blood count abnormal | 12.23 | 10.99 | 8 | 60252 | 16339 | 31620745 |
Dry mouth | 12.19 | 10.99 | 84 | 60176 | 24374 | 31612710 |
Death | 12.19 | 10.99 | 561 | 59699 | 360008 | 31277076 |
Panic reaction | 12.13 | 10.99 | 14 | 60246 | 1358 | 31635726 |
Candida infection | 12.10 | 10.99 | 8 | 60252 | 16250 | 31620834 |
Cyclothymic disorder | 12.05 | 10.99 | 5 | 60255 | 85 | 31636999 |
Blood urea increased | 12.05 | 10.99 | 23 | 60237 | 28989 | 31608095 |
Blood bilirubin increased | 12.01 | 10.99 | 31 | 60229 | 35105 | 31601979 |
Speech disorder | 11.99 | 10.99 | 83 | 60177 | 24118 | 31612966 |
Dyspnoea exertional | 11.99 | 10.99 | 36 | 60224 | 38801 | 31598283 |
Cardiac failure congestive | 11.97 | 10.99 | 95 | 60165 | 79292 | 31557792 |
Locked-in syndrome | 11.95 | 10.99 | 7 | 60253 | 257 | 31636827 |
Urinary retention | 11.93 | 10.99 | 107 | 60153 | 33618 | 31603466 |
Thought insertion | 11.92 | 10.99 | 3 | 60257 | 8 | 31637076 |
Self esteem decreased | 11.91 | 10.99 | 9 | 60251 | 508 | 31636576 |
Arthropathy | 11.91 | 10.99 | 17 | 60243 | 24034 | 31613050 |
Staring | 11.89 | 10.99 | 14 | 60246 | 1388 | 31635696 |
Nausea | 11.89 | 10.99 | 472 | 59788 | 307475 | 31329609 |
Therapeutic response unexpected | 11.88 | 10.99 | 41 | 60219 | 8983 | 31628101 |
Chronic kidney disease | 11.87 | 10.99 | 35 | 60225 | 37940 | 31599144 |
Inflammatory bowel disease | 11.84 | 10.99 | 19 | 60241 | 2524 | 31634560 |
Psychiatric symptom | 11.83 | 10.99 | 22 | 60238 | 3289 | 31633795 |
Sleep apnoea syndrome | 11.79 | 10.99 | 68 | 60192 | 18557 | 31618527 |
Abdominal distension | 11.69 | 10.99 | 53 | 60207 | 50631 | 31586453 |
Cortisol increased | 11.69 | 10.99 | 6 | 60254 | 169 | 31636915 |
Mental status changes | 11.66 | 10.99 | 112 | 60148 | 35856 | 31601228 |
Drooling | 11.60 | 10.99 | 21 | 60239 | 3074 | 31634010 |
Sinus tachycardia | 11.47 | 10.99 | 60 | 60200 | 15789 | 31621295 |
Mixed delusion | 11.47 | 10.99 | 4 | 60256 | 41 | 31637043 |
Coordination abnormal | 11.40 | 10.99 | 35 | 60225 | 7216 | 31629868 |
Haemophagocytic lymphohistiocytosis | 11.35 | 10.99 | 4 | 60256 | 11674 | 31625410 |
Carbon monoxide poisoning | 11.30 | 10.99 | 5 | 60255 | 100 | 31636984 |
Gastric hypomotility | 11.26 | 10.99 | 5 | 60255 | 101 | 31636983 |
Water intoxication | 11.22 | 10.99 | 8 | 60252 | 413 | 31636671 |
Galactorrhoea | 11.22 | 10.99 | 8 | 60252 | 413 | 31636671 |
COVID-19 pneumonia | 11.21 | 10.99 | 5 | 60255 | 12650 | 31624434 |
Genital anaesthesia | 11.20 | 10.99 | 3 | 60257 | 11 | 31637073 |
Thyroxine free abnormal | 11.20 | 10.99 | 3 | 60257 | 11 | 31637073 |
Ankyloglossia congenital | 11.19 | 10.99 | 7 | 60253 | 290 | 31636794 |
Productive cough | 11.15 | 10.99 | 30 | 60230 | 33510 | 31603574 |
Peripheral venous disease | 11.07 | 10.99 | 18 | 60242 | 2418 | 31634666 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Completed suicide | 1913.89 | 9.82 | 2458 | 158087 | 224677 | 70543222 |
Serotonin syndrome | 1399.10 | 9.82 | 979 | 159566 | 41135 | 70726764 |
Intentional overdose | 1112.86 | 9.82 | 1239 | 159306 | 97196 | 70670703 |
Toxicity to various agents | 1093.83 | 9.82 | 2562 | 157983 | 379610 | 70388289 |
Suicidal ideation | 980.20 | 9.82 | 985 | 159560 | 68611 | 70699288 |
Suicide attempt | 714.15 | 9.82 | 890 | 159655 | 78620 | 70689279 |
Drug abuse | 678.01 | 9.82 | 1204 | 159341 | 146052 | 70621847 |
Drug interaction | 674.65 | 9.82 | 2144 | 158401 | 379297 | 70388602 |
Depression | 607.13 | 9.82 | 1370 | 159175 | 197604 | 70570295 |
Anxiety | 490.36 | 9.82 | 1345 | 159200 | 218985 | 70548914 |
Intentional self-injury | 480.61 | 9.82 | 467 | 160078 | 31183 | 70736716 |
Electrocardiogram QT prolonged | 419.44 | 9.82 | 710 | 159835 | 82807 | 70685092 |
Overdose | 394.25 | 9.82 | 1053 | 159492 | 168692 | 70599207 |
Rheumatoid arthritis | 343.65 | 9.82 | 116 | 160429 | 291689 | 70476210 |
Agitation | 333.72 | 9.82 | 686 | 159859 | 92689 | 70675210 |
Tremor | 317.45 | 9.82 | 921 | 159624 | 154703 | 70613196 |
Poisoning | 299.65 | 9.82 | 310 | 160235 | 22312 | 70745587 |
Drug withdrawal syndrome | 286.77 | 9.82 | 362 | 160183 | 32353 | 70735546 |
Respiratory arrest | 260.79 | 9.82 | 451 | 160094 | 53482 | 70714417 |
Cardiac arrest | 249.84 | 9.82 | 863 | 159682 | 158971 | 70608928 |
Obsessive-compulsive disorder | 236.64 | 9.82 | 149 | 160396 | 5221 | 70762678 |
Synovitis | 233.19 | 9.82 | 15 | 160530 | 129213 | 70638686 |
Febrile neutropenia | 227.24 | 9.82 | 89 | 160456 | 204229 | 70563670 |
Akathisia | 226.35 | 9.82 | 202 | 160343 | 12091 | 70755808 |
Cardio-respiratory arrest | 223.92 | 9.82 | 615 | 159930 | 100062 | 70667837 |
Aggression | 214.73 | 9.82 | 390 | 160155 | 48056 | 70719843 |
Contraindicated product administered | 203.08 | 9.82 | 31 | 160514 | 134581 | 70633318 |
Irritability | 201.16 | 9.82 | 332 | 160213 | 37893 | 70730006 |
Torsade de pointes | 199.15 | 9.82 | 225 | 160320 | 17891 | 70750008 |
Withdrawal syndrome | 192.45 | 9.82 | 259 | 160286 | 24645 | 70743254 |
Somnolence | 183.01 | 9.82 | 967 | 159578 | 214639 | 70553260 |
Suicidal behaviour | 182.12 | 9.82 | 103 | 160442 | 2953 | 70764946 |
Depressed mood | 181.94 | 9.82 | 343 | 160202 | 43477 | 70724422 |
Joint swelling | 180.55 | 9.82 | 184 | 160361 | 253027 | 70514872 |
Hand deformity | 172.53 | 9.82 | 5 | 160540 | 86477 | 70681422 |
Infusion related reaction | 170.93 | 9.82 | 119 | 160426 | 197415 | 70570484 |
Drug intolerance | 166.65 | 9.82 | 159 | 160386 | 225528 | 70542371 |
Pneumonia | 157.74 | 9.82 | 754 | 159791 | 595478 | 70172421 |
Reversible cerebral vasoconstriction syndrome | 155.98 | 9.82 | 89 | 160456 | 2596 | 70765303 |
Poisoning deliberate | 153.03 | 9.82 | 191 | 160354 | 16869 | 70751030 |
Systemic lupus erythematosus | 152.48 | 9.82 | 24 | 160521 | 101878 | 70666021 |
Tardive dyskinesia | 147.86 | 9.82 | 145 | 160400 | 9784 | 70758115 |
Mania | 145.68 | 9.82 | 187 | 160358 | 16987 | 70750912 |
Treatment failure | 141.19 | 9.82 | 75 | 160470 | 144067 | 70623832 |
Pericarditis | 138.61 | 9.82 | 15 | 160530 | 84690 | 70683209 |
Rash | 138.27 | 9.82 | 640 | 159905 | 509922 | 70257977 |
Peripheral swelling | 135.91 | 9.82 | 203 | 160342 | 236360 | 70531539 |
Nightmare | 135.28 | 9.82 | 206 | 160339 | 21950 | 70745949 |
Disturbance in attention | 134.54 | 9.82 | 299 | 160246 | 42595 | 70725304 |
Anaemia | 132.94 | 9.82 | 468 | 160077 | 402955 | 70364944 |
Coma | 130.62 | 9.82 | 481 | 160064 | 91363 | 70676536 |
Respiratory depression | 129.74 | 9.82 | 215 | 160330 | 24616 | 70743283 |
Panic attack | 128.52 | 9.82 | 201 | 160344 | 21918 | 70745981 |
Drug dependence | 128.31 | 9.82 | 270 | 160275 | 37051 | 70730848 |
Infection | 127.88 | 9.82 | 174 | 160371 | 210611 | 70557288 |
Intentional product misuse | 126.17 | 9.82 | 432 | 160113 | 79163 | 70688736 |
Sopor | 125.17 | 9.82 | 241 | 160304 | 31026 | 70736873 |
Mydriasis | 124.81 | 9.82 | 168 | 160377 | 15985 | 70751914 |
Pyrexia | 123.97 | 9.82 | 835 | 159710 | 606117 | 70161782 |
Muscle twitching | 123.40 | 9.82 | 186 | 160359 | 19641 | 70748258 |
Seizure | 118.77 | 9.82 | 749 | 159796 | 177213 | 70590686 |
Wound | 114.77 | 9.82 | 40 | 160505 | 98692 | 70669207 |
General physical health deterioration | 112.40 | 9.82 | 228 | 160317 | 235803 | 70532096 |
Malignant neoplasm progression | 111.14 | 9.82 | 69 | 160476 | 121670 | 70646229 |
Homicide | 108.47 | 9.82 | 53 | 160492 | 1117 | 70766782 |
Thrombocytopenia | 106.34 | 9.82 | 240 | 160305 | 238870 | 70529029 |
Swelling | 106.13 | 9.82 | 164 | 160381 | 188375 | 70579524 |
Neutropenia | 104.97 | 9.82 | 270 | 160275 | 256886 | 70511013 |
Arthropathy | 104.67 | 9.82 | 111 | 160434 | 149946 | 70617953 |
Abnormal behaviour | 102.22 | 9.82 | 236 | 160309 | 34473 | 70733426 |
Crying | 102.07 | 9.82 | 177 | 160368 | 21022 | 70746877 |
Arthralgia | 101.95 | 9.82 | 694 | 159851 | 502696 | 70265203 |
Platelet count decreased | 101.30 | 9.82 | 154 | 160391 | 178068 | 70589831 |
Pancytopenia | 100.76 | 9.82 | 116 | 160429 | 150991 | 70616908 |
Off label use | 100.27 | 9.82 | 1138 | 159407 | 741922 | 70025977 |
Generalised tonic-clonic seizure | 99.10 | 9.82 | 261 | 160284 | 41400 | 70726499 |
Extrapyramidal disorder | 96.98 | 9.82 | 171 | 160374 | 20579 | 70747320 |
Muscle rigidity | 96.78 | 9.82 | 161 | 160384 | 18489 | 70749410 |
Paranoia | 96.16 | 9.82 | 154 | 160391 | 17134 | 70750765 |
Dystonia | 94.18 | 9.82 | 164 | 160381 | 19542 | 70748357 |
Therapeutic product effect decreased | 94.05 | 9.82 | 111 | 160434 | 142907 | 70624992 |
Myoclonus | 93.32 | 9.82 | 193 | 160352 | 26162 | 70741737 |
Helicobacter infection | 93.27 | 9.82 | 9 | 160536 | 55647 | 70712252 |
Hyperreflexia | 93.20 | 9.82 | 99 | 160446 | 7343 | 70760556 |
Restless legs syndrome | 92.85 | 9.82 | 157 | 160388 | 18271 | 70749628 |
Rheumatoid factor positive | 92.35 | 9.82 | 4 | 160541 | 48396 | 70719503 |
Hepatic enzyme increased | 91.79 | 9.82 | 133 | 160412 | 156857 | 70611042 |
Alopecia | 90.89 | 9.82 | 196 | 160349 | 198294 | 70569605 |
Euphoric mood | 90.48 | 9.82 | 94 | 160451 | 6795 | 70761104 |
Sedation | 89.82 | 9.82 | 271 | 160274 | 46460 | 70721439 |
Self-injurious ideation | 88.98 | 9.82 | 68 | 160477 | 3270 | 70764629 |
Disease progression | 88.43 | 9.82 | 136 | 160409 | 156536 | 70611363 |
Stomatitis | 87.47 | 9.82 | 97 | 160448 | 128414 | 70639485 |
Tic | 87.10 | 9.82 | 62 | 160483 | 2671 | 70765228 |
Coma scale abnormal | 86.14 | 9.82 | 99 | 160446 | 8017 | 70759882 |
Dyskinesia | 85.44 | 9.82 | 245 | 160300 | 40829 | 70727070 |
Electrocardiogram QRS complex prolonged | 85.10 | 9.82 | 108 | 160437 | 9698 | 70758201 |
Hyperhidrosis | 84.77 | 9.82 | 549 | 159996 | 131037 | 70636862 |
Anger | 84.70 | 9.82 | 140 | 160405 | 15992 | 70751907 |
Psychotic disorder | 84.44 | 9.82 | 231 | 160314 | 37470 | 70730429 |
Galactorrhoea | 83.92 | 9.82 | 66 | 160479 | 3312 | 70764587 |
Clonus | 83.17 | 9.82 | 86 | 160459 | 6182 | 70761717 |
Nasopharyngitis | 82.67 | 9.82 | 244 | 160301 | 221962 | 70545937 |
Glossodynia | 81.77 | 9.82 | 47 | 160498 | 86440 | 70681459 |
Restlessness | 81.62 | 9.82 | 245 | 160300 | 41883 | 70726016 |
Renal impairment | 81.18 | 9.82 | 125 | 160420 | 143812 | 70624087 |
Sepsis | 80.90 | 9.82 | 283 | 160262 | 244262 | 70523637 |
Tearfulness | 79.81 | 9.82 | 76 | 160469 | 4944 | 70762955 |
Miosis | 78.96 | 9.82 | 126 | 160419 | 13975 | 70753924 |
Hallucination, auditory | 77.97 | 9.82 | 145 | 160400 | 18183 | 70749716 |
Mucosal inflammation | 77.97 | 9.82 | 28 | 160517 | 67822 | 70700077 |
Atrial fibrillation | 77.17 | 9.82 | 191 | 160354 | 184157 | 70583742 |
Drug ineffective | 76.46 | 9.82 | 1586 | 158959 | 938166 | 69829733 |
Diarrhoea | 75.76 | 9.82 | 1283 | 159262 | 782058 | 69985841 |
Mental disorder | 75.57 | 9.82 | 185 | 160360 | 28055 | 70739844 |
Mood swings | 74.48 | 9.82 | 142 | 160403 | 18144 | 70749755 |
Acute kidney injury | 72.76 | 9.82 | 705 | 159840 | 473919 | 70293980 |
Duodenal ulcer perforation | 72.16 | 9.82 | 14 | 160531 | 51098 | 70716801 |
C-reactive protein increased | 71.35 | 9.82 | 87 | 160458 | 110430 | 70657469 |
Parkinsonism | 71.24 | 9.82 | 126 | 160419 | 15199 | 70752700 |
Depressed level of consciousness | 70.56 | 9.82 | 387 | 160158 | 87044 | 70680855 |
Abdominal discomfort | 69.93 | 9.82 | 250 | 160295 | 214408 | 70553491 |
Abnormal dreams | 69.61 | 9.82 | 102 | 160443 | 10501 | 70757398 |
Accidental death | 69.54 | 9.82 | 63 | 160482 | 3845 | 70764054 |
Insomnia | 67.47 | 9.82 | 772 | 159773 | 217034 | 70550865 |
Lower respiratory tract infection | 67.20 | 9.82 | 93 | 160452 | 111820 | 70656079 |
Discomfort | 67.02 | 9.82 | 84 | 160461 | 105352 | 70662547 |
Impulsive behaviour | 66.68 | 9.82 | 53 | 160492 | 2701 | 70765198 |
Product substitution issue | 66.04 | 9.82 | 136 | 160409 | 18377 | 70749522 |
Confusional state | 63.75 | 9.82 | 950 | 159595 | 283448 | 70484451 |
Bezoar | 63.73 | 9.82 | 48 | 160497 | 2258 | 70765641 |
Cytomegalovirus infection | 62.65 | 9.82 | 8 | 160537 | 39750 | 70728149 |
Memory impairment | 62.42 | 9.82 | 391 | 160154 | 92250 | 70675649 |
Antipsychotic drug level increased | 62.24 | 9.82 | 69 | 160476 | 5371 | 70762528 |
Hypersensitivity | 62.08 | 9.82 | 288 | 160257 | 229524 | 70538375 |
Sleep disorder due to general medical condition, insomnia type | 61.98 | 9.82 | 5 | 160540 | 35727 | 70732172 |
Folliculitis | 61.51 | 9.82 | 11 | 160534 | 42559 | 70725340 |
Hallucination | 61.16 | 9.82 | 337 | 160208 | 75923 | 70691976 |
Intentional product use issue | 60.67 | 9.82 | 112 | 160433 | 120030 | 70647869 |
Cardiac failure | 60.63 | 9.82 | 148 | 160397 | 143393 | 70624506 |
Mood altered | 59.92 | 9.82 | 122 | 160423 | 16353 | 70751546 |
Drug abuser | 59.68 | 9.82 | 70 | 160475 | 5794 | 70762105 |
Disinhibition | 59.42 | 9.82 | 46 | 160499 | 2255 | 70765644 |
Product complaint | 58.72 | 9.82 | 102 | 160443 | 12129 | 70755770 |
Hostility | 58.06 | 9.82 | 45 | 160500 | 2210 | 70765689 |
Blister | 57.93 | 9.82 | 86 | 160459 | 100440 | 70667459 |
Emotional distress | 57.30 | 9.82 | 200 | 160345 | 36988 | 70730911 |
Homicidal ideation | 56.07 | 9.82 | 52 | 160493 | 3271 | 70764628 |
C-reactive protein abnormal | 55.67 | 9.82 | 10 | 160535 | 38569 | 70729330 |
Muscle injury | 55.50 | 9.82 | 10 | 160535 | 38484 | 70729415 |
Impaired healing | 55.30 | 9.82 | 52 | 160493 | 74322 | 70693577 |
Affective disorder | 55.07 | 9.82 | 76 | 160469 | 7403 | 70760496 |
Social avoidant behaviour | 54.90 | 9.82 | 60 | 160485 | 4596 | 70763303 |
Victim of child abuse | 54.24 | 9.82 | 31 | 160514 | 907 | 70766992 |
Cholecystitis chronic | 54.18 | 9.82 | 85 | 160460 | 9291 | 70758608 |
Myocardial depression | 52.76 | 9.82 | 25 | 160520 | 491 | 70767408 |
Major depression | 52.73 | 9.82 | 80 | 160465 | 8494 | 70759405 |
Septic shock | 52.06 | 9.82 | 110 | 160435 | 112148 | 70655751 |
Pain | 51.92 | 9.82 | 1058 | 159487 | 627758 | 70140141 |
Libido increased | 51.86 | 9.82 | 39 | 160506 | 1830 | 70766069 |
Drug level increased | 51.82 | 9.82 | 191 | 160354 | 36278 | 70731621 |
Apathy | 51.65 | 9.82 | 95 | 160450 | 11813 | 70756086 |
Dissociation | 51.57 | 9.82 | 50 | 160495 | 3326 | 70764573 |
Stress cardiomyopathy | 50.99 | 9.82 | 85 | 160460 | 9777 | 70758122 |
Decorticate posture | 50.63 | 9.82 | 21 | 160524 | 296 | 70767603 |
Haemoglobin decreased | 50.28 | 9.82 | 266 | 160279 | 204893 | 70563006 |
Mobility decreased | 50.26 | 9.82 | 98 | 160447 | 102901 | 70664998 |
Myelosuppression | 50.18 | 9.82 | 5 | 160540 | 30140 | 70737759 |
Gastrointestinal disorder | 50.00 | 9.82 | 102 | 160443 | 105325 | 70662574 |
Feeling abnormal | 49.83 | 9.82 | 517 | 160028 | 141802 | 70626097 |
Blood creatinine increased | 49.63 | 9.82 | 162 | 160383 | 142839 | 70625060 |
Neuroleptic malignant syndrome | 49.20 | 9.82 | 150 | 160395 | 25857 | 70742042 |
Herpes zoster | 49.03 | 9.82 | 73 | 160472 | 85162 | 70682737 |
Blood prolactin increased | 48.90 | 9.82 | 51 | 160494 | 3703 | 70764196 |
Hyperprolactinaemia | 48.82 | 9.82 | 55 | 160490 | 4358 | 70763541 |
Nervousness | 48.50 | 9.82 | 168 | 160377 | 30952 | 70736947 |
Thinking abnormal | 48.36 | 9.82 | 93 | 160452 | 11958 | 70755941 |
Obsessive-compulsive symptom | 47.89 | 9.82 | 18 | 160527 | 192 | 70767707 |
Hepatic function abnormal | 47.73 | 9.82 | 50 | 160495 | 67946 | 70699953 |
Product use issue | 47.69 | 9.82 | 227 | 160318 | 179710 | 70588189 |
Oculogyric crisis | 47.04 | 9.82 | 43 | 160502 | 2655 | 70765244 |
Speech disorder | 46.39 | 9.82 | 232 | 160313 | 50348 | 70717551 |
Migraine | 46.25 | 9.82 | 301 | 160244 | 71937 | 70695962 |
Dyspnoea | 46.02 | 9.82 | 1360 | 159185 | 768700 | 69999199 |
Fear | 45.10 | 9.82 | 126 | 160419 | 20685 | 70747214 |
Cough | 44.59 | 9.82 | 496 | 160049 | 324881 | 70443018 |
Erythema | 44.43 | 9.82 | 267 | 160278 | 199296 | 70568603 |
Psychomotor hyperactivity | 44.41 | 9.82 | 104 | 160441 | 15329 | 70752570 |
Persistent genital arousal disorder | 43.74 | 9.82 | 19 | 160526 | 302 | 70767597 |
Pleural effusion | 43.73 | 9.82 | 154 | 160391 | 132710 | 70635189 |
Long QT syndrome | 43.61 | 9.82 | 57 | 160488 | 5270 | 70762629 |
Parasomnia | 43.24 | 9.82 | 22 | 160523 | 507 | 70767392 |
Neuropathy peripheral | 43.18 | 9.82 | 145 | 160400 | 126751 | 70641148 |
Bone marrow failure | 43.05 | 9.82 | 29 | 160516 | 48981 | 70718918 |
Sinus bradycardia | 42.60 | 9.82 | 134 | 160411 | 23489 | 70744410 |
Blood pressure fluctuation | 41.86 | 9.82 | 43 | 160502 | 58969 | 70708930 |
Cerebral vasoconstriction | 41.78 | 9.82 | 30 | 160515 | 1310 | 70766589 |
Poor quality sleep | 40.98 | 9.82 | 120 | 160425 | 20229 | 70747670 |
Plasma cell myeloma | 40.84 | 9.82 | 64 | 160481 | 73137 | 70694762 |
Dependence | 40.77 | 9.82 | 37 | 160508 | 2263 | 70765636 |
Synaesthesia | 40.75 | 9.82 | 8 | 160537 | 0 | 70767899 |
Blood hyposmosis | 40.68 | 9.82 | 10 | 160535 | 18 | 70767881 |
Arthritis | 40.60 | 9.82 | 102 | 160443 | 97878 | 70670021 |
Physical assault | 39.81 | 9.82 | 31 | 160514 | 1533 | 70766366 |
Hyperkalaemia | 38.92 | 9.82 | 118 | 160427 | 106473 | 70661426 |
Morbid thoughts | 38.47 | 9.82 | 23 | 160522 | 733 | 70767166 |
Atrioventricular block first degree | 38.44 | 9.82 | 83 | 160462 | 11590 | 70756309 |
Neoplasm progression | 38.09 | 9.82 | 28 | 160517 | 45200 | 70722699 |
Increased appetite | 37.89 | 9.82 | 78 | 160467 | 10535 | 70757364 |
Anorgasmia | 37.81 | 9.82 | 26 | 160519 | 1059 | 70766840 |
Bradyphrenia | 37.78 | 9.82 | 75 | 160470 | 9871 | 70758028 |
Libido decreased | 37.78 | 9.82 | 51 | 160494 | 4865 | 70763034 |
Alcohol poisoning | 37.76 | 9.82 | 48 | 160497 | 4317 | 70763582 |
Bruxism | 37.10 | 9.82 | 44 | 160501 | 3685 | 70764214 |
Eye movement disorder | 36.97 | 9.82 | 63 | 160482 | 7377 | 70760522 |
Sinus tachycardia | 36.53 | 9.82 | 163 | 160382 | 33750 | 70734149 |
Reduced facial expression | 36.24 | 9.82 | 35 | 160510 | 2317 | 70765582 |
Tachycardia | 35.62 | 9.82 | 530 | 160015 | 158016 | 70609883 |
White blood cell count decreased | 35.61 | 9.82 | 232 | 160313 | 169909 | 70597990 |
Prostate cancer | 35.56 | 9.82 | 13 | 160532 | 31150 | 70736749 |
Amnesia | 35.04 | 9.82 | 220 | 160325 | 51935 | 70715964 |
Blood lactate dehydrogenase increased | 34.78 | 9.82 | 18 | 160527 | 35109 | 70732790 |
Cogwheel rigidity | 34.57 | 9.82 | 38 | 160507 | 2930 | 70764969 |
Ill-defined disorder | 34.37 | 9.82 | 44 | 160501 | 54697 | 70713202 |
Bipolar I disorder | 34.30 | 9.82 | 31 | 160514 | 1886 | 70766013 |
Flat affect | 34.21 | 9.82 | 31 | 160514 | 1892 | 70766007 |
Suspected suicide | 34.02 | 9.82 | 67 | 160478 | 8767 | 70759132 |
Inappropriate antidiuretic hormone secretion | 33.99 | 9.82 | 123 | 160422 | 23153 | 70744746 |
Derealisation | 33.89 | 9.82 | 28 | 160517 | 1508 | 70766391 |
Panic reaction | 33.88 | 9.82 | 45 | 160500 | 4226 | 70763673 |
Yawning | 33.47 | 9.82 | 26 | 160519 | 1281 | 70766618 |
Asphyxia | 33.44 | 9.82 | 73 | 160472 | 10269 | 70757630 |
Huntington's disease | 33.44 | 9.82 | 8 | 160537 | 12 | 70767887 |
Binge eating | 33.38 | 9.82 | 18 | 160527 | 469 | 70767430 |
Feeling guilty | 33.27 | 9.82 | 22 | 160523 | 839 | 70767060 |
Drug hypersensitivity | 33.26 | 9.82 | 407 | 160138 | 262052 | 70505847 |
Traumatic coma | 33.13 | 9.82 | 10 | 160535 | 50 | 70767849 |
Mental impairment | 33.08 | 9.82 | 100 | 160445 | 17155 | 70750744 |
Therapeutic product effect incomplete | 33.08 | 9.82 | 149 | 160396 | 119733 | 70648166 |
Marital problem | 32.96 | 9.82 | 14 | 160531 | 210 | 70767689 |
Alcoholism | 32.47 | 9.82 | 45 | 160500 | 4400 | 70763499 |
Unresponsive to stimuli | 32.40 | 9.82 | 215 | 160330 | 51716 | 70716183 |
Foetal exposure during pregnancy | 32.37 | 9.82 | 51 | 160494 | 5594 | 70762305 |
Ascites | 32.32 | 9.82 | 65 | 160480 | 67482 | 70700417 |
Bipolar disorder | 32.12 | 9.82 | 60 | 160485 | 7548 | 70760351 |
Violence-related symptom | 31.98 | 9.82 | 20 | 160525 | 692 | 70767207 |
Obsessive thoughts | 31.72 | 9.82 | 23 | 160522 | 1020 | 70766879 |
Hallucination, visual | 31.60 | 9.82 | 141 | 160404 | 29196 | 70738703 |
Borderline personality disorder | 31.21 | 9.82 | 21 | 160524 | 825 | 70767074 |
Soft tissue injury | 31.11 | 9.82 | 28 | 160517 | 1694 | 70766205 |
Lethargy | 31.05 | 9.82 | 283 | 160262 | 74967 | 70692932 |
Hypomania | 30.94 | 9.82 | 52 | 160493 | 6020 | 70761879 |
Heart sounds | 30.91 | 9.82 | 20 | 160525 | 735 | 70767164 |
Abnormal sleep-related event | 30.72 | 9.82 | 21 | 160524 | 847 | 70767052 |
Pulseless electrical activity | 30.61 | 9.82 | 82 | 160463 | 13133 | 70754766 |
Social anxiety disorder | 30.35 | 9.82 | 17 | 160528 | 478 | 70767421 |
Multiple sclerosis relapse | 29.86 | 9.82 | 183 | 160362 | 42834 | 70725065 |
Tension | 29.79 | 9.82 | 41 | 160504 | 3983 | 70763916 |
Dysarthria | 29.72 | 9.82 | 242 | 160303 | 62071 | 70705828 |
Staring | 29.57 | 9.82 | 32 | 160513 | 2424 | 70765475 |
Emotional disorder | 29.57 | 9.82 | 81 | 160464 | 13145 | 70754754 |
Dysphoria | 29.13 | 9.82 | 43 | 160502 | 4455 | 70763444 |
Rhabdomyolysis | 28.97 | 9.82 | 338 | 160207 | 95422 | 70672477 |
Visceral congestion | 28.88 | 9.82 | 20 | 160525 | 824 | 70767075 |
Inflammation | 28.77 | 9.82 | 87 | 160458 | 78578 | 70689321 |
Red blood cell sedimentation rate increased | 28.74 | 9.82 | 27 | 160518 | 38615 | 70729284 |
Delusion | 28.60 | 9.82 | 102 | 160443 | 19063 | 70748836 |
Negative thoughts | 28.52 | 9.82 | 24 | 160521 | 1326 | 70766573 |
Dysphemia | 28.41 | 9.82 | 36 | 160509 | 3227 | 70764672 |
Basilar migraine | 28.31 | 9.82 | 9 | 160536 | 55 | 70767844 |
Initial insomnia | 28.21 | 9.82 | 51 | 160494 | 6258 | 70761641 |
Weight increased | 28.14 | 9.82 | 733 | 159812 | 241598 | 70526301 |
Tachyphrenia | 28.13 | 9.82 | 28 | 160517 | 1923 | 70765976 |
Multiple organ dysfunction syndrome | 28.10 | 9.82 | 138 | 160407 | 108377 | 70659522 |
Hypersomnia | 28.04 | 9.82 | 107 | 160438 | 20657 | 70747242 |
Accidental overdose | 28.01 | 9.82 | 155 | 160390 | 34966 | 70732933 |
Hyponatraemia | 27.77 | 9.82 | 513 | 160032 | 159574 | 70608325 |
Cataplexy | 27.69 | 9.82 | 21 | 160524 | 998 | 70766901 |
Respiration abnormal | 27.58 | 9.82 | 53 | 160492 | 6811 | 70761088 |
Loss of libido | 27.42 | 9.82 | 31 | 160514 | 2466 | 70765433 |
Depressive symptom | 27.25 | 9.82 | 45 | 160500 | 5136 | 70762763 |
Aspergillus infection | 27.19 | 9.82 | 4 | 160541 | 17864 | 70750035 |
Influenza like illness | 27.11 | 9.82 | 246 | 160299 | 65085 | 70702814 |
Carbon monoxide poisoning | 27.04 | 9.82 | 13 | 160532 | 264 | 70767635 |
Catatonia | 26.98 | 9.82 | 58 | 160487 | 8075 | 70759824 |
Depersonalisation/derealisation disorder | 26.91 | 9.82 | 26 | 160519 | 1722 | 70766177 |
Sinusitis | 26.40 | 9.82 | 250 | 160295 | 168945 | 70598954 |
Liver disorder | 26.36 | 9.82 | 63 | 160482 | 61505 | 70706394 |
Oxygen saturation decreased | 26.30 | 9.82 | 155 | 160390 | 116274 | 70651625 |
Blunted affect | 26.18 | 9.82 | 15 | 160530 | 441 | 70767458 |
Obesity | 26.12 | 9.82 | 125 | 160420 | 26646 | 70741253 |
Antipsychotic drug level below therapeutic | 26.11 | 9.82 | 20 | 160525 | 965 | 70766934 |
Multiple sclerosis | 26.09 | 9.82 | 120 | 160425 | 25165 | 70742734 |
Prolonged expiration | 25.97 | 9.82 | 20 | 160525 | 973 | 70766926 |
Blood bilirubin increased | 25.88 | 9.82 | 61 | 160484 | 59840 | 70708059 |
Transplant rejection | 25.60 | 9.82 | 5 | 160540 | 18166 | 70749733 |
Sternal fracture | 25.49 | 9.82 | 29 | 160516 | 2322 | 70765577 |
Ventricular hypokinesia | 25.46 | 9.82 | 57 | 160488 | 8155 | 70759744 |
Somnambulism | 25.42 | 9.82 | 44 | 160501 | 5216 | 70762683 |
Musculoskeletal stiffness | 25.39 | 9.82 | 213 | 160332 | 147547 | 70620352 |
Decreased interest | 25.39 | 9.82 | 35 | 160510 | 3406 | 70764493 |
Antidepressant drug level increased | 25.15 | 9.82 | 14 | 160531 | 389 | 70767510 |
Treatment noncompliance | 25.05 | 9.82 | 186 | 160359 | 46388 | 70721511 |
Thrombotic microangiopathy | 24.96 | 9.82 | 5 | 160540 | 17843 | 70750056 |
Self esteem decreased | 24.85 | 9.82 | 19 | 160526 | 914 | 70766985 |
Bulimia nervosa | 24.60 | 9.82 | 12 | 160533 | 252 | 70767647 |
Burning mouth syndrome | 24.60 | 9.82 | 15 | 160530 | 496 | 70767403 |
Disorientation | 24.49 | 9.82 | 219 | 160326 | 57704 | 70710195 |
Epidural lipomatosis | 24.43 | 9.82 | 19 | 160526 | 938 | 70766961 |
Coordination abnormal | 24.40 | 9.82 | 86 | 160459 | 15980 | 70751919 |
Tumour lysis syndrome | 24.22 | 9.82 | 9 | 160536 | 21351 | 70746548 |
Posture abnormal | 24.19 | 9.82 | 35 | 160510 | 3561 | 70764338 |
Cytokine release syndrome | 24.14 | 9.82 | 15 | 160530 | 26452 | 70741447 |
Heart rate | 24.00 | 9.82 | 8 | 160537 | 58 | 70767841 |
Serum serotonin decreased | 23.99 | 9.82 | 6 | 160539 | 12 | 70767887 |
Palmar-plantar erythrodysaesthesia syndrome | 23.86 | 9.82 | 20 | 160525 | 30227 | 70737672 |
Breast discomfort | 23.72 | 9.82 | 13 | 160532 | 350 | 70767549 |
Bacteraemia | 23.59 | 9.82 | 19 | 160526 | 29290 | 70738609 |
Sleep disorder | 23.58 | 9.82 | 252 | 160293 | 69620 | 70698279 |
Neutrophil count decreased | 23.56 | 9.82 | 103 | 160442 | 83453 | 70684446 |
Cystostomy | 23.53 | 9.82 | 8 | 160537 | 62 | 70767837 |
Protein C increased | 23.46 | 9.82 | 9 | 160536 | 102 | 70767797 |
Priapism | 23.39 | 9.82 | 37 | 160508 | 4073 | 70763826 |
Drug screen positive | 23.35 | 9.82 | 45 | 160500 | 5795 | 70762104 |
Gastrointestinal haemorrhage | 23.20 | 9.82 | 199 | 160346 | 137209 | 70630690 |
Compulsive shopping | 23.11 | 9.82 | 17 | 160528 | 771 | 70767128 |
Therapeutic response unexpected | 23.04 | 9.82 | 92 | 160453 | 18139 | 70749760 |
Anterograde amnesia | 22.96 | 9.82 | 16 | 160529 | 666 | 70767233 |
Diet failure | 22.87 | 9.82 | 7 | 160538 | 37 | 70767862 |
Hip arthroplasty | 22.79 | 9.82 | 18 | 160527 | 28022 | 70739877 |
Polyneuropathy | 22.69 | 9.82 | 10 | 160535 | 21405 | 70746494 |
Haemophagocytic lymphohistiocytosis | 22.69 | 9.82 | 8 | 160537 | 19604 | 70748295 |
Irritable bowel syndrome | 22.60 | 9.82 | 51 | 160494 | 50799 | 70717100 |
Formication | 22.57 | 9.82 | 39 | 160506 | 4618 | 70763281 |
Sleep-related eating disorder | 22.40 | 9.82 | 16 | 160529 | 693 | 70767206 |
Pneumocystis jirovecii pneumonia | 22.39 | 9.82 | 21 | 160524 | 30061 | 70737838 |
Hypertonia | 22.31 | 9.82 | 47 | 160498 | 6451 | 70761448 |
Choreoathetosis | 22.31 | 9.82 | 22 | 160523 | 1494 | 70766405 |
Musculoskeletal pain | 22.17 | 9.82 | 117 | 160428 | 90210 | 70677689 |
Disseminated intravascular coagulation | 22.15 | 9.82 | 26 | 160519 | 33572 | 70734327 |
Trichotillomania | 22.10 | 9.82 | 10 | 160535 | 176 | 70767723 |
Hyporesponsive to stimuli | 21.93 | 9.82 | 24 | 160521 | 1841 | 70766058 |
Autonomic nervous system imbalance | 21.90 | 9.82 | 37 | 160508 | 4302 | 70763597 |
Oral discharge | 21.80 | 9.82 | 11 | 160534 | 249 | 70767650 |
Heart rate decreased | 21.68 | 9.82 | 70 | 160475 | 61945 | 70705954 |
Blood pressure diastolic decreased | 21.66 | 9.82 | 16 | 160529 | 25764 | 70742135 |
Sluggishness | 21.60 | 9.82 | 44 | 160501 | 5899 | 70762000 |
Product use in unapproved indication | 21.52 | 9.82 | 335 | 160210 | 207143 | 70560756 |
Chorea | 21.47 | 9.82 | 25 | 160520 | 2053 | 70765846 |
Graft versus host disease | 21.45 | 9.82 | 4 | 160541 | 15019 | 70752880 |
Urinary incontinence | 21.43 | 9.82 | 153 | 160392 | 37689 | 70730210 |
Foetal arrhythmia | 21.21 | 9.82 | 7 | 160538 | 49 | 70767850 |
Blood pressure systolic increased | 21.17 | 9.82 | 63 | 160482 | 57196 | 70710703 |
Tourette's disorder | 21.15 | 9.82 | 8 | 160537 | 87 | 70767812 |
Jaundice neonatal | 21.07 | 9.82 | 9 | 160536 | 137 | 70767762 |
Exposure via ingestion | 21.05 | 9.82 | 39 | 160506 | 4876 | 70763023 |
Stress | 21.05 | 9.82 | 241 | 160304 | 67725 | 70700174 |
Haematotoxicity | 20.95 | 9.82 | 3 | 160542 | 13671 | 70754228 |
Panic disorder | 20.93 | 9.82 | 29 | 160516 | 2835 | 70765064 |
Osteonecrosis of jaw | 20.89 | 9.82 | 38 | 160507 | 40964 | 70726935 |
Post-traumatic neck syndrome | 20.83 | 9.82 | 24 | 160521 | 1949 | 70765950 |
Myelodysplastic syndrome | 20.79 | 9.82 | 22 | 160523 | 29763 | 70738136 |
Single umbilical artery | 20.71 | 9.82 | 5 | 160540 | 8 | 70767891 |
Child abuse | 20.70 | 9.82 | 12 | 160533 | 361 | 70767538 |
Hallucinations, mixed | 20.68 | 9.82 | 45 | 160500 | 6317 | 70761582 |
Dreamy state | 20.40 | 9.82 | 7 | 160538 | 56 | 70767843 |
Agitation neonatal | 20.37 | 9.82 | 4 | 160541 | 0 | 70767899 |
Phobia | 20.34 | 9.82 | 12 | 160533 | 373 | 70767526 |
Economic problem | 20.28 | 9.82 | 25 | 160520 | 2179 | 70765720 |
Ideas of reference | 20.23 | 9.82 | 9 | 160536 | 152 | 70767747 |
Alcohol use | 20.17 | 9.82 | 37 | 160508 | 4590 | 70763309 |
Pathogen resistance | 20.15 | 9.82 | 3 | 160542 | 13276 | 70754623 |
Patent ductus arteriosus | 20.08 | 9.82 | 8 | 160537 | 101 | 70767798 |
Personality disorder | 20.07 | 9.82 | 41 | 160504 | 5507 | 70762392 |
Alcohol interaction | 20.03 | 9.82 | 37 | 160508 | 4616 | 70763283 |
Analgesic drug level increased | 19.78 | 9.82 | 26 | 160519 | 2417 | 70765482 |
Thought insertion | 19.56 | 9.82 | 6 | 160539 | 32 | 70767867 |
IIIrd nerve paresis | 19.41 | 9.82 | 9 | 160536 | 168 | 70767731 |
Genital anaesthesia | 19.37 | 9.82 | 5 | 160540 | 12 | 70767887 |
Oedema | 19.33 | 9.82 | 146 | 160399 | 103435 | 70664464 |
Accommodation disorder | 19.29 | 9.82 | 13 | 160532 | 512 | 70767387 |
Acute myeloid leukaemia | 19.29 | 9.82 | 25 | 160520 | 30915 | 70736984 |
Depression suicidal | 19.28 | 9.82 | 28 | 160517 | 2859 | 70765040 |
Respiratory disorder | 19.27 | 9.82 | 37 | 160508 | 39086 | 70728813 |
Feeling drunk | 19.14 | 9.82 | 35 | 160510 | 4332 | 70763567 |
Hospitalisation | 19.14 | 9.82 | 109 | 160436 | 82459 | 70685440 |
CYP3A4 polymorphism | 19.03 | 9.82 | 7 | 160538 | 70 | 70767829 |
Bronchopulmonary aspergillosis | 19.02 | 9.82 | 12 | 160533 | 20990 | 70746909 |
Oedema peripheral | 18.97 | 9.82 | 383 | 160162 | 227708 | 70540191 |
Concussion | 18.91 | 9.82 | 52 | 160493 | 8457 | 70759442 |
Drug eruption | 18.90 | 9.82 | 38 | 160507 | 39458 | 70728441 |
Metabolic acidosis | 18.88 | 9.82 | 254 | 160291 | 74092 | 70693807 |
Vision blurred | 18.84 | 9.82 | 311 | 160234 | 94673 | 70673226 |
Agoraphobia | 18.74 | 9.82 | 13 | 160532 | 537 | 70767362 |
Loss of consciousness | 18.64 | 9.82 | 473 | 160072 | 155243 | 70612656 |
Hypoalbuminaemia | 18.63 | 9.82 | 10 | 160535 | 19112 | 70748787 |
Induced abortion failed | 18.49 | 9.82 | 9 | 160536 | 188 | 70767711 |
Mental status changes | 18.32 | 9.82 | 221 | 160324 | 62880 | 70705019 |
Injury | 18.29 | 9.82 | 227 | 160318 | 65018 | 70702881 |
Serum sickness-like reaction | 18.28 | 9.82 | 13 | 160532 | 559 | 70767340 |
Gallbladder disorder | 18.23 | 9.82 | 84 | 160461 | 17628 | 70750271 |
Knee arthroplasty | 18.19 | 9.82 | 31 | 160514 | 34270 | 70733629 |
Feeling of despair | 18.12 | 9.82 | 26 | 160519 | 2625 | 70765274 |
Sexual dysfunction | 18.12 | 9.82 | 44 | 160501 | 6637 | 70761262 |
Blood urea increased | 18.09 | 9.82 | 49 | 160496 | 45860 | 70722039 |
Diffuse large B-cell lymphoma | 18.04 | 9.82 | 4 | 160541 | 13298 | 70754601 |
Myocardial infarction | 17.84 | 9.82 | 277 | 160268 | 171368 | 70596531 |
Colitis | 17.78 | 9.82 | 79 | 160466 | 63735 | 70704164 |
Retinal phototoxicity | 17.61 | 9.82 | 4 | 160541 | 4 | 70767895 |
Enterocolitis | 17.57 | 9.82 | 4 | 160541 | 13062 | 70754837 |
Psoriatic arthropathy | 17.56 | 9.82 | 81 | 160464 | 64690 | 70703209 |
Cardiac failure congestive | 17.54 | 9.82 | 209 | 160336 | 135248 | 70632651 |
Peritonitis | 17.51 | 9.82 | 20 | 160525 | 26139 | 70741760 |
Tenosynovitis | 17.41 | 9.82 | 5 | 160540 | 13971 | 70753928 |
Hypercalcaemia | 17.40 | 9.82 | 32 | 160513 | 34353 | 70733546 |
Anaphylactic reaction | 17.36 | 9.82 | 99 | 160446 | 74875 | 70693024 |
Serum ferritin abnormal | 17.35 | 9.82 | 11 | 160534 | 390 | 70767509 |
Pupil fixed | 17.33 | 9.82 | 29 | 160516 | 3345 | 70764554 |
Joint range of motion decreased | 17.31 | 9.82 | 20 | 160525 | 26006 | 70741893 |
Chronic actinic dermatitis | 17.27 | 9.82 | 5 | 160540 | 21 | 70767878 |
Drooling | 17.16 | 9.82 | 38 | 160507 | 5398 | 70762501 |
Neonatal seizure | 17.14 | 9.82 | 4 | 160541 | 5 | 70767894 |
Amenorrhoea | 17.07 | 9.82 | 44 | 160501 | 6886 | 70761013 |
Posterior reversible encephalopathy syndrome | 17.06 | 9.82 | 18 | 160527 | 24384 | 70743515 |
Proteinuria | 17.04 | 9.82 | 25 | 160520 | 29349 | 70738550 |
Pseudomonas infection | 17.00 | 9.82 | 11 | 160534 | 18983 | 70748916 |
Cytopenia | 16.97 | 9.82 | 9 | 160536 | 17314 | 70750585 |
Bladder cancer | 16.83 | 9.82 | 9 | 160536 | 17233 | 70750666 |
Pruritus | 16.82 | 9.82 | 626 | 159919 | 344934 | 70422965 |
Narcolepsy | 16.72 | 9.82 | 17 | 160528 | 1198 | 70766701 |
Liver function test increased | 16.68 | 9.82 | 32 | 160513 | 33815 | 70734084 |
Breast enlargement | 16.61 | 9.82 | 18 | 160527 | 1366 | 70766533 |
Supraventricular tachyarrhythmia | 16.60 | 9.82 | 7 | 160538 | 103 | 70767796 |
Neutropenic sepsis | 16.60 | 9.82 | 19 | 160526 | 24811 | 70743088 |
Anhedonia | 16.60 | 9.82 | 70 | 160475 | 14143 | 70753756 |
Dehydroepiandrosterone decreased | 16.56 | 9.82 | 5 | 160540 | 25 | 70767874 |
Complication of device insertion | 16.52 | 9.82 | 37 | 160508 | 5295 | 70762604 |
Pituitary tumour benign | 16.49 | 9.82 | 24 | 160521 | 2455 | 70765444 |
Psychomotor retardation | 16.41 | 9.82 | 38 | 160507 | 5560 | 70762339 |
Gambling disorder | 16.27 | 9.82 | 21 | 160524 | 1917 | 70765982 |
Antisocial personality disorder | 16.25 | 9.82 | 5 | 160540 | 27 | 70767872 |
Ventricular fibrillation | 16.16 | 9.82 | 111 | 160434 | 27000 | 70740899 |
Cerebral infarction | 16.13 | 9.82 | 47 | 160498 | 42962 | 70724937 |
Diverticulitis | 16.10 | 9.82 | 45 | 160500 | 41689 | 70726210 |
Oesophageal food impaction | 16.07 | 9.82 | 10 | 160535 | 343 | 70767556 |
Cholecystectomy | 16.06 | 9.82 | 49 | 160496 | 8448 | 70759451 |
Hypnopompic hallucination | 16.05 | 9.82 | 6 | 160539 | 63 | 70767836 |
Breath sounds abnormal | 16 | 9.82 | 5 | 160540 | 13226 | 70754673 |
Tinnitus | 15.92 | 9.82 | 138 | 160407 | 36038 | 70731861 |
Secondary hypogonadism | 15.89 | 9.82 | 10 | 160535 | 350 | 70767549 |
Agranulocytosis | 15.89 | 9.82 | 43 | 160502 | 40255 | 70727644 |
Appetite disorder | 15.80 | 9.82 | 43 | 160502 | 6952 | 70760947 |
Disturbance in sexual arousal | 15.78 | 9.82 | 8 | 160537 | 183 | 70767716 |
Interstitial lung disease | 15.76 | 9.82 | 156 | 160389 | 104529 | 70663370 |
Confabulation | 15.76 | 9.82 | 11 | 160534 | 459 | 70767440 |
Antisocial behaviour | 15.70 | 9.82 | 12 | 160533 | 577 | 70767322 |
Constipation | 15.70 | 9.82 | 443 | 160102 | 251995 | 70515904 |
Device placement issue | 15.70 | 9.82 | 14 | 160531 | 837 | 70767062 |
Rash maculo-papular | 15.69 | 9.82 | 60 | 160485 | 50485 | 70717414 |
Swollen tongue | 15.62 | 9.82 | 140 | 160405 | 36906 | 70730993 |
Renal failure | 15.56 | 9.82 | 318 | 160227 | 188752 | 70579147 |
Parkinsonian gait | 15.51 | 9.82 | 14 | 160531 | 850 | 70767049 |
Gastric bypass | 15.50 | 9.82 | 16 | 160529 | 1148 | 70766751 |
Spinal shock | 15.40 | 9.82 | 5 | 160540 | 33 | 70767866 |
Respiratory failure | 15.35 | 9.82 | 279 | 160266 | 168456 | 70599443 |
Drug-induced liver injury | 15.32 | 9.82 | 70 | 160475 | 56043 | 70711856 |
Sleep paralysis | 15.31 | 9.82 | 12 | 160533 | 599 | 70767300 |
Feeling jittery | 15.19 | 9.82 | 59 | 160486 | 11484 | 70756415 |
Selective mutism | 15.19 | 9.82 | 6 | 160539 | 74 | 70767825 |
Transaminases increased | 15.13 | 9.82 | 55 | 160490 | 46963 | 70720936 |
Hypoplastic left heart syndrome | 15.11 | 9.82 | 4 | 160541 | 11 | 70767888 |
Therapeutic product effect variable | 15.10 | 9.82 | 19 | 160526 | 1691 | 70766208 |
Energy increased | 15.10 | 9.82 | 25 | 160520 | 2859 | 70765040 |
Self-medication | 15.10 | 9.82 | 32 | 160513 | 4411 | 70763488 |
Cellulitis | 15.07 | 9.82 | 147 | 160398 | 98781 | 70669118 |
Sudden onset of sleep | 15.04 | 9.82 | 12 | 160533 | 615 | 70767284 |
Micturition urgency | 15.03 | 9.82 | 58 | 160487 | 11256 | 70756643 |
Nystagmus | 15.01 | 9.82 | 51 | 160494 | 9304 | 70758595 |
Mast cell activation syndrome | 15.00 | 9.82 | 12 | 160533 | 617 | 70767282 |
Blood magnesium decreased | 14.99 | 9.82 | 70 | 160475 | 14771 | 70753128 |
Fatigue | 14.94 | 9.82 | 1636 | 158909 | 822683 | 69945216 |
Dizziness | 14.94 | 9.82 | 1232 | 159313 | 462909 | 70304990 |
Delusion of grandeur | 14.93 | 9.82 | 14 | 160531 | 893 | 70767006 |
Slow response to stimuli | 14.90 | 9.82 | 19 | 160526 | 1714 | 70766185 |
Cytomegalovirus viraemia | 14.90 | 9.82 | 4 | 160541 | 11681 | 70756218 |
Dermatillomania | 14.85 | 9.82 | 8 | 160537 | 208 | 70767691 |
Tubulointerstitial nephritis | 14.84 | 9.82 | 33 | 160512 | 33043 | 70734856 |
Hypersexuality | 14.82 | 9.82 | 18 | 160527 | 1545 | 70766354 |
Death of relative | 14.82 | 9.82 | 8 | 160537 | 209 | 70767690 |
Personality change | 14.80 | 9.82 | 49 | 160496 | 8821 | 70759078 |
Autism spectrum disorder | 14.78 | 9.82 | 15 | 160530 | 1055 | 70766844 |
Asthenia | 14.68 | 9.82 | 867 | 159678 | 456799 | 70311100 |
Atrioventricular block second degree | 14.65 | 9.82 | 41 | 160504 | 6737 | 70761162 |
Haematochezia | 14.60 | 9.82 | 101 | 160444 | 72980 | 70694919 |
Blood pressure measurement | 14.59 | 9.82 | 10 | 160535 | 405 | 70767494 |
Locked-in syndrome | 14.58 | 9.82 | 12 | 160533 | 643 | 70767256 |
Pregnancy on oral contraceptive | 14.51 | 9.82 | 13 | 160532 | 782 | 70767117 |
COVID-19 pneumonia | 14.48 | 9.82 | 17 | 160528 | 21952 | 70745947 |
Resting tremor | 14.47 | 9.82 | 17 | 160528 | 1409 | 70766490 |
Bradycardia | 14.46 | 9.82 | 377 | 160168 | 124238 | 70643661 |
Incubator therapy | 14.46 | 9.82 | 5 | 160540 | 41 | 70767858 |
Attention deficit hyperactivity disorder | 14.46 | 9.82 | 25 | 160520 | 2962 | 70764937 |
Logorrhoea | 14.41 | 9.82 | 30 | 160515 | 4084 | 70763815 |
Skin ulcer | 14.40 | 9.82 | 58 | 160487 | 48087 | 70719812 |
Hypoprolactinaemia | 14.39 | 9.82 | 4 | 160541 | 14 | 70767885 |
Atrial septal defect | 14.39 | 9.82 | 19 | 160526 | 1774 | 70766125 |
Hyperthermia | 14.26 | 9.82 | 75 | 160470 | 16596 | 70751303 |
Coma uraemic | 14.25 | 9.82 | 5 | 160540 | 43 | 70767856 |
Large intestine perforation | 14.24 | 9.82 | 6 | 160539 | 13189 | 70754710 |
Body temperature decreased | 14.22 | 9.82 | 27 | 160518 | 28645 | 70739254 |
Eating disorder | 14.18 | 9.82 | 81 | 160464 | 18484 | 70749415 |
Jaw clicking | 14.17 | 9.82 | 4 | 160541 | 15 | 70767884 |
Grip strength decreased | 14.15 | 9.82 | 9 | 160536 | 15676 | 70752223 |
Metastases to lung | 14.15 | 9.82 | 10 | 160535 | 16474 | 70751425 |
Exposure during pregnancy | 14.14 | 9.82 | 278 | 160267 | 87439 | 70680460 |
Post 5-alpha-reductase inhibitor syndrome | 14.13 | 9.82 | 6 | 160539 | 90 | 70767809 |
Pulmonary haemosiderosis | 14.06 | 9.82 | 5 | 160540 | 45 | 70767854 |
Pneumothorax | 14.03 | 9.82 | 23 | 160522 | 25823 | 70742076 |
Creatinine renal clearance decreased | 14.03 | 9.82 | 11 | 160534 | 17189 | 70750710 |
Anorexia nervosa | 14.03 | 9.82 | 8 | 160537 | 233 | 70767666 |
Pericardial effusion | 14.02 | 9.82 | 48 | 160497 | 41728 | 70726171 |
Basal cell carcinoma | 14.02 | 9.82 | 35 | 160510 | 33663 | 70734236 |
Alcohol withdrawal syndrome | 14.00 | 9.82 | 19 | 160526 | 1822 | 70766077 |
Fluid retention | 13.99 | 9.82 | 85 | 160460 | 63300 | 70704599 |
Balance disorder | 13.98 | 9.82 | 284 | 160261 | 89844 | 70678055 |
Osteoporosis | 13.96 | 9.82 | 60 | 160485 | 48847 | 70719052 |
Bradykinesia | 13.94 | 9.82 | 43 | 160502 | 7459 | 70760440 |
Tongue biting | 13.93 | 9.82 | 19 | 160526 | 1830 | 70766069 |
Therapy change | 13.93 | 9.82 | 40 | 160505 | 6669 | 70761230 |
Foetal monitoring abnormal | 13.89 | 9.82 | 7 | 160538 | 158 | 70767741 |
Productive cough | 13.87 | 9.82 | 112 | 160433 | 78225 | 70689674 |
Salivary hypersecretion | 13.83 | 9.82 | 62 | 160483 | 12863 | 70755036 |
Impulse-control disorder | 13.80 | 9.82 | 18 | 160527 | 1661 | 70766238 |
Pulmonary arterial hypertension | 13.76 | 9.82 | 34 | 160511 | 32821 | 70735078 |
Vaginal haemorrhage | 13.76 | 9.82 | 86 | 160459 | 20266 | 70747633 |
Blood test abnormal | 13.68 | 9.82 | 8 | 160537 | 14582 | 70753317 |
Cold agglutinins positive | 13.68 | 9.82 | 5 | 160540 | 49 | 70767850 |
Hypoxic-ischaemic encephalopathy | 13.68 | 9.82 | 42 | 160503 | 7266 | 70760633 |
Gestational diabetes | 13.66 | 9.82 | 37 | 160508 | 5964 | 70761935 |
Myasthenic syndrome | 13.62 | 9.82 | 12 | 160533 | 706 | 70767193 |
Chemical burn | 13.61 | 9.82 | 10 | 160535 | 453 | 70767446 |
Prolonged rupture of membranes | 13.59 | 9.82 | 5 | 160540 | 50 | 70767849 |
Road traffic accident | 13.58 | 9.82 | 129 | 160416 | 34553 | 70733346 |
Enuresis | 13.58 | 9.82 | 24 | 160521 | 2893 | 70765006 |
Asthma | 13.56 | 9.82 | 192 | 160353 | 120601 | 70647298 |
Haemorrhage intracranial | 13.50 | 9.82 | 22 | 160523 | 24755 | 70743144 |
Loss of personal independence in daily activities | 13.43 | 9.82 | 125 | 160420 | 84785 | 70683114 |
Compulsions | 13.43 | 9.82 | 9 | 160536 | 351 | 70767548 |
Candida infection | 13.43 | 9.82 | 37 | 160508 | 34436 | 70733463 |
Ventricular hypertrophy | 13.42 | 9.82 | 39 | 160506 | 6545 | 70761354 |
Heart disease congenital | 13.42 | 9.82 | 11 | 160534 | 586 | 70767313 |
Mutism | 13.38 | 9.82 | 20 | 160525 | 2096 | 70765803 |
Skin cancer | 13.31 | 9.82 | 7 | 160538 | 13529 | 70754370 |
Appendicitis | 13.28 | 9.82 | 11 | 160534 | 16722 | 70751177 |
Thrombosis | 13.26 | 9.82 | 108 | 160437 | 75297 | 70692602 |
Abortion spontaneous | 13.26 | 9.82 | 104 | 160441 | 26375 | 70741524 |
Umbilical cord around neck | 13.25 | 9.82 | 4 | 160541 | 20 | 70767879 |
Renal disorder | 13.22 | 9.82 | 43 | 160502 | 37966 | 70729933 |
Purple glove syndrome | 13.19 | 9.82 | 8 | 160537 | 262 | 70767637 |
Klebsiella infection | 13.17 | 9.82 | 8 | 160537 | 14284 | 70753615 |
Hyperdynamic left ventricle | 13.14 | 9.82 | 9 | 160536 | 364 | 70767535 |
Premature baby | 13.14 | 9.82 | 26 | 160519 | 3413 | 70764486 |
Decreased appetite | 13.12 | 9.82 | 560 | 159985 | 304220 | 70463679 |
Electrolyte depletion | 13.12 | 9.82 | 9 | 160536 | 365 | 70767534 |
Joint hyperextension | 13.11 | 9.82 | 8 | 160537 | 265 | 70767634 |
Pain in extremity | 13.07 | 9.82 | 608 | 159937 | 327474 | 70440425 |
Blood pressure increased | 12.98 | 9.82 | 326 | 160219 | 188191 | 70579708 |
Venoocclusive liver disease | 12.98 | 9.82 | 4 | 160541 | 10674 | 70757225 |
Panniculitis | 12.97 | 9.82 | 4 | 160541 | 10672 | 70757227 |
Dissociative disorder | 12.96 | 9.82 | 10 | 160535 | 488 | 70767411 |
Antidepressant drug level above therapeutic | 12.95 | 9.82 | 11 | 160534 | 616 | 70767283 |
Blood creatine phosphokinase MB | 12.94 | 9.82 | 4 | 160541 | 22 | 70767877 |
Haemolysis | 12.88 | 9.82 | 5 | 160540 | 11546 | 70756353 |
Cholangitis | 12.87 | 9.82 | 5 | 160540 | 11544 | 70756355 |
Ventricular arrhythmia | 12.84 | 9.82 | 43 | 160502 | 7787 | 70760112 |
Gastric disorder | 12.80 | 9.82 | 36 | 160509 | 33286 | 70734613 |
Status migrainosus | 12.78 | 9.82 | 5 | 160540 | 60 | 70767839 |
Dissociative identity disorder | 12.63 | 9.82 | 5 | 160540 | 62 | 70767837 |
Blood triglycerides increased | 12.62 | 9.82 | 82 | 160463 | 19582 | 70748317 |
Multiple system atrophy | 12.62 | 9.82 | 9 | 160536 | 389 | 70767510 |
Cataract | 12.60 | 9.82 | 74 | 160471 | 55571 | 70712328 |
Ventricular tachycardia | 12.58 | 9.82 | 132 | 160413 | 36291 | 70731608 |
Faecal calprotectin | 12.51 | 9.82 | 4 | 160541 | 25 | 70767874 |
Blood potassium decreased | 12.50 | 9.82 | 149 | 160396 | 42272 | 70725627 |
Second primary malignancy | 12.46 | 9.82 | 7 | 160538 | 13044 | 70754855 |
Procedural hypertension | 12.44 | 9.82 | 8 | 160537 | 291 | 70767608 |
Brugada syndrome | 12.43 | 9.82 | 14 | 160531 | 1109 | 70766790 |
Vascular stenosis | 12.37 | 9.82 | 10 | 160535 | 522 | 70767377 |
Back pain | 12.35 | 9.82 | 495 | 160050 | 270657 | 70497242 |
Urinary retention | 12.34 | 9.82 | 177 | 160368 | 52343 | 70715556 |
Enterococcal infection | 12.31 | 9.82 | 9 | 160536 | 14573 | 70753326 |
Intrusive thoughts | 12.24 | 9.82 | 9 | 160536 | 408 | 70767491 |
Blood pressure systolic abnormal | 12.22 | 9.82 | 7 | 160538 | 12902 | 70754997 |
Compulsive hoarding | 12.21 | 9.82 | 5 | 160540 | 68 | 70767831 |
Device related infection | 12.20 | 9.82 | 35 | 160510 | 32150 | 70735749 |
Haemorrhage | 12.16 | 9.82 | 126 | 160419 | 83689 | 70684210 |
End stage renal disease | 12.11 | 9.82 | 5 | 160540 | 11128 | 70756771 |
Hypothermia | 12.09 | 9.82 | 84 | 160461 | 20510 | 70747389 |
Metastases to bone | 12.07 | 9.82 | 20 | 160525 | 22356 | 70745543 |
Red blood cell count decreased | 12.01 | 9.82 | 69 | 160476 | 52092 | 70715807 |
Tremor neonatal | 12.00 | 9.82 | 3 | 160542 | 6 | 70767893 |
Apgar score low | 12.00 | 9.82 | 3 | 160542 | 6 | 70767893 |
Right aortic arch | 12.00 | 9.82 | 3 | 160542 | 6 | 70767893 |
Acquired cardiac septal defect | 12.00 | 9.82 | 3 | 160542 | 6 | 70767893 |
Lumbar radiculopathy | 11.88 | 9.82 | 18 | 160527 | 1908 | 70765991 |
Coagulation factor VII level decreased | 11.88 | 9.82 | 7 | 160538 | 217 | 70767682 |
Plasma cell mastitis | 11.88 | 9.82 | 4 | 160541 | 30 | 70767869 |
Electrocardiogram repolarisation abnormality | 11.86 | 9.82 | 18 | 160527 | 1911 | 70765988 |
Toxic skin eruption | 11.85 | 9.82 | 17 | 160528 | 20145 | 70747754 |
Appendicitis perforated | 11.84 | 9.82 | 23 | 160522 | 2980 | 70764919 |
Agonal rhythm | 11.83 | 9.82 | 5 | 160540 | 74 | 70767825 |
Duodenal ulcer repair | 11.77 | 9.82 | 5 | 160540 | 75 | 70767824 |
Muscle necrosis | 11.76 | 9.82 | 15 | 160530 | 1353 | 70766546 |
Intervertebral disc displacement | 11.74 | 9.82 | 9 | 160536 | 435 | 70767464 |
Disability | 11.70 | 9.82 | 10 | 160535 | 14973 | 70752926 |
Bursitis | 11.65 | 9.82 | 27 | 160518 | 26646 | 70741253 |
Enthesopathy | 11.64 | 9.82 | 5 | 160540 | 10864 | 70757035 |
Grandiosity | 11.62 | 9.82 | 10 | 160535 | 570 | 70767329 |
Cardiomegaly | 11.53 | 9.82 | 95 | 160450 | 24450 | 70743449 |
Cholinergic syndrome | 11.47 | 9.82 | 12 | 160533 | 874 | 70767025 |
Chronic fatigue syndrome | 11.47 | 9.82 | 14 | 160531 | 1208 | 70766691 |
Persecutory delusion | 11.46 | 9.82 | 29 | 160516 | 4488 | 70763411 |
Placenta praevia | 11.45 | 9.82 | 11 | 160534 | 723 | 70767176 |
Food interaction | 11.45 | 9.82 | 16 | 160529 | 1577 | 70766322 |
Premature labour | 11.45 | 9.82 | 42 | 160503 | 7958 | 70759941 |
Stereotypy | 11.34 | 9.82 | 12 | 160533 | 886 | 70767013 |
Accidental poisoning | 11.32 | 9.82 | 16 | 160529 | 1594 | 70766305 |
Hypogammaglobulinaemia | 11.29 | 9.82 | 6 | 160539 | 11532 | 70756367 |
Renal artery thrombosis | 11.28 | 9.82 | 9 | 160536 | 461 | 70767438 |
Hypnagogic hallucination | 11.28 | 9.82 | 6 | 160539 | 152 | 70767747 |
Cerebrovascular stenosis | 11.28 | 9.82 | 6 | 160539 | 152 | 70767747 |
Theft | 11.23 | 9.82 | 7 | 160538 | 241 | 70767658 |
Epistaxis | 11.21 | 9.82 | 164 | 160381 | 102463 | 70665436 |
Rabbit syndrome | 11.19 | 9.82 | 8 | 160537 | 347 | 70767552 |
Psychotic behaviour | 11.15 | 9.82 | 13 | 160532 | 1069 | 70766830 |
Pulmonary valve stenosis | 11.15 | 9.82 | 4 | 160541 | 37 | 70767862 |
Medical diet | 11.14 | 9.82 | 3 | 160542 | 9 | 70767890 |
Neonatal respiratory distress syndrome | 11.12 | 9.82 | 7 | 160538 | 245 | 70767654 |
Gout | 11.12 | 9.82 | 22 | 160523 | 22984 | 70744915 |
Oral candidiasis | 11.11 | 9.82 | 25 | 160520 | 24927 | 70742972 |
Exposure via inhalation | 11.10 | 9.82 | 5 | 160540 | 87 | 70767812 |
Regurgitation | 11.07 | 9.82 | 19 | 160526 | 2237 | 70765662 |
Maternal drugs affecting foetus | 11.06 | 9.82 | 16 | 160529 | 1628 | 70766271 |
Vasoplegia syndrome | 11.04 | 9.82 | 23 | 160522 | 3133 | 70764766 |
Accidental exposure to product | 11.00 | 9.82 | 30 | 160515 | 28021 | 70739878 |
Developmental delay | 11.00 | 9.82 | 13 | 160532 | 1085 | 70766814 |
Pre-eclampsia | 10.98 | 9.82 | 36 | 160509 | 6449 | 70761450 |
Alpha 1 globulin increased | 10.95 | 9.82 | 5 | 160540 | 90 | 70767809 |
Chronic kidney disease | 10.95 | 9.82 | 87 | 160458 | 60970 | 70706929 |
Dyspnoea exertional | 10.94 | 9.82 | 119 | 160426 | 78311 | 70689588 |
Hyperinsulinism | 10.90 | 9.82 | 3 | 160542 | 10 | 70767889 |
Peripheral sensory neuropathy | 10.86 | 9.82 | 7 | 160538 | 12103 | 70755796 |
Heavy menstrual bleeding | 10.85 | 9.82 | 57 | 160488 | 12608 | 70755291 |
Acute psychosis | 10.84 | 9.82 | 26 | 160519 | 3890 | 70764009 |
Osteonecrosis | 10.84 | 9.82 | 32 | 160513 | 29128 | 70738771 |
Gaze palsy | 10.83 | 9.82 | 21 | 160524 | 2717 | 70765182 |
Transient aphasia | 10.77 | 9.82 | 6 | 160539 | 167 | 70767732 |
Legal problem | 10.74 | 9.82 | 6 | 160539 | 168 | 70767731 |
Withdrawal catatonia | 10.74 | 9.82 | 6 | 160539 | 168 | 70767731 |
Anal incontinence | 10.73 | 9.82 | 69 | 160476 | 16421 | 70751478 |
Prostatic specific antigen increased | 10.71 | 9.82 | 4 | 160541 | 9462 | 70758437 |
Colitis ulcerative | 10.70 | 9.82 | 40 | 160505 | 33883 | 70734016 |
Loss of bladder sensation | 10.70 | 9.82 | 5 | 160540 | 95 | 70767804 |
Head deformity | 10.70 | 9.82 | 4 | 160541 | 42 | 70767857 |
Febrile bone marrow aplasia | 10.66 | 9.82 | 7 | 160538 | 11984 | 70755915 |
Full blood count abnormal | 10.66 | 9.82 | 40 | 160505 | 33838 | 70734061 |
Full blood count decreased | 10.62 | 9.82 | 24 | 160521 | 23894 | 70744005 |
Colorectal cancer | 10.61 | 9.82 | 3 | 160542 | 8467 | 70759432 |
Metastases to central nervous system | 10.61 | 9.82 | 11 | 160534 | 15023 | 70752876 |
Hypervolaemia | 10.56 | 9.82 | 50 | 160495 | 39656 | 70728243 |
Squamous cell carcinoma of skin | 10.54 | 9.82 | 8 | 160537 | 12704 | 70755195 |
Lymphatic system neoplasm | 10.53 | 9.82 | 4 | 160541 | 44 | 70767855 |
Melanocytic hyperplasia | 10.48 | 9.82 | 3 | 160542 | 12 | 70767887 |
Cushingoid | 10.45 | 9.82 | 3 | 160542 | 8385 | 70759514 |
Sleep attacks | 10.42 | 9.82 | 6 | 160539 | 178 | 70767721 |
Toxic epidermal necrolysis | 10.41 | 9.82 | 50 | 160495 | 39507 | 70728392 |
Eye colour change | 10.41 | 9.82 | 8 | 160537 | 388 | 70767511 |
Drug withdrawal syndrome neonatal | 10.40 | 9.82 | 7 | 160538 | 275 | 70767624 |
Maternal exposure during pregnancy | 10.40 | 9.82 | 191 | 160354 | 115154 | 70652745 |
Device expulsion | 10.39 | 9.82 | 86 | 160459 | 22160 | 70745739 |
Hypertriglyceridaemia | 10.36 | 9.82 | 7 | 160538 | 11804 | 70756095 |
Affect lability | 10.35 | 9.82 | 48 | 160497 | 10098 | 70757801 |
Gastric hypomotility | 10.33 | 9.82 | 6 | 160539 | 181 | 70767718 |
Skin necrosis | 10.32 | 9.82 | 13 | 160532 | 16278 | 70751621 |
Uterine hypertonus | 10.31 | 9.82 | 7 | 160538 | 279 | 70767620 |
Haematuria | 10.31 | 9.82 | 93 | 160452 | 63480 | 70704419 |
Trismus | 10.23 | 9.82 | 30 | 160515 | 5061 | 70762838 |
Biliary dyskinesia | 10.23 | 9.82 | 19 | 160526 | 2380 | 70765519 |
Drug resistance | 10.21 | 9.82 | 48 | 160497 | 38142 | 70729757 |
Gastrointestinal hypermotility | 10.18 | 9.82 | 7 | 160538 | 285 | 70767614 |
Menstruation irregular | 10.16 | 9.82 | 28 | 160517 | 4560 | 70763339 |
Osteoarthritis | 10.14 | 9.82 | 113 | 160432 | 74034 | 70693865 |
Platelet count increased | 10.14 | 9.82 | 19 | 160526 | 20254 | 70747645 |
Blood uric acid increased | 10.10 | 9.82 | 4 | 160541 | 9125 | 70758774 |
Blood pressure decreased | 10.08 | 9.82 | 146 | 160399 | 91369 | 70676530 |
Skin infection | 10.06 | 9.82 | 13 | 160532 | 16099 | 70751800 |
Imprisonment | 10.03 | 9.82 | 9 | 160536 | 542 | 70767357 |
Clostridium difficile colitis | 9.95 | 9.82 | 33 | 160512 | 28963 | 70738936 |
Alpha 2 globulin decreased | 9.94 | 9.82 | 3 | 160542 | 15 | 70767884 |
Sex hormone binding globulin decreased | 9.94 | 9.82 | 3 | 160542 | 15 | 70767884 |
Pregnancy with contraceptive patch | 9.94 | 9.82 | 3 | 160542 | 15 | 70767884 |
Testicular microlithiasis | 9.94 | 9.82 | 3 | 160542 | 15 | 70767884 |
Otosalpingitis | 9.94 | 9.82 | 3 | 160542 | 15 | 70767884 |
Internal haemorrhage | 9.94 | 9.82 | 3 | 160542 | 8113 | 70759786 |
Metastases to liver | 9.91 | 9.82 | 28 | 160517 | 25850 | 70742049 |
Blood glucose fluctuation | 9.91 | 9.82 | 34 | 160511 | 6233 | 70761666 |
Blood parathyroid hormone decreased | 9.90 | 9.82 | 4 | 160541 | 9020 | 70758879 |
Localised infection | 9.88 | 9.82 | 40 | 160505 | 33118 | 70734781 |
Bradypnoea | 9.87 | 9.82 | 31 | 160514 | 5428 | 70762471 |
Hypoglycaemia neonatal | 9.87 | 9.82 | 4 | 160541 | 53 | 70767846 |
Optic ischaemic neuropathy | 9.87 | 9.82 | 20 | 160525 | 2672 | 70765227 |
Foetal alcohol syndrome | 9.87 | 9.82 | 4 | 160541 | 53 | 70767846 |
Lung disorder | 9.86 | 9.82 | 105 | 160440 | 69379 | 70698520 |
Alanine aminotransferase abnormal | 9.83 | 9.82 | 3 | 160542 | 8056 | 70759843 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Feeling jittery | 45.63 | 22.91 | 18 | 774 | 44 | 88956 |
Exposure during pregnancy | 32.11 | 22.91 | 48 | 744 | 1286 | 87714 |
Hypertonia neonatal | 27.90 | 22.91 | 23 | 769 | 304 | 88696 |
Tremor neonatal | 22.95 | 22.91 | 13 | 779 | 87 | 88913 |
Source | Code | Description |
---|---|---|
ATC | N06AB03 | NERVOUS SYSTEM PSYCHOANALEPTICS ANTIDEPRESSANTS Selective serotonin reuptake inhibitors |
ATC | N06CA03 | NERVOUS SYSTEM PSYCHOANALEPTICS PSYCHOLEPTICS AND PSYCHOANALEPTICS IN COMBINATION Antidepressants in combination with psycholeptics |
FDA MoA | N0000000109 | Serotonin Uptake Inhibitors |
CHEBI has role | CHEBI:35469 | antidepressants |
CHEBI has role | CHEBI:35703 | Xenobiotic |
CHEBI has role | CHEBI:50949 | SSRI |
CHEBI has role | CHEBI:78298 | environmental contaminants |
CHEBI has role | CHEBI:88188 | allergenic drug |
MeSH PA | D000928 | Antidepressive Agents |
MeSH PA | D018687 | Antidepressive Agents, Second-Generation |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D065690 | Cytochrome P-450 CYP2D6 Inhibitors |
MeSH PA | D065607 | Cytochrome P-450 Enzyme Inhibitors |
MeSH PA | D004791 | Enzyme Inhibitors |
MeSH PA | D049990 | Membrane Transport Modulators |
MeSH PA | D065606 | Metabolic Side Effects of Drugs and Substances |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D014179 | Neurotransmitter Uptake Inhibitors |
MeSH PA | D011619 | Psychotropic Drugs |
MeSH PA | D018490 | Serotonin Agents |
MeSH PA | D017367 | Serotonin Uptake Inhibitors |
FDA EPC | N0000175696 | Serotonin Reuptake Inhibitor |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Premenstrual dysphoric disorder | indication | 596004 | |
Depressive disorder | indication | 35489007 | |
Bulimia nervosa | indication | 78004001 | |
Bipolar affective disorder, current episode depression | indication | 191627008 | DOID:3312 |
Obsessive-compulsive disorder | indication | 191736004 | DOID:10933 |
Major depressive disorder | indication | 370143000 | |
Panic disorder | indication | 371631005 | DOID:594 |
Posttraumatic stress disorder | off-label use | 47505003 | DOID:2055 |
Postpartum depression | off-label use | 58703003 | DOID:9478 |
Cataplexy and narcolepsy | off-label use | 193042000 | |
Menopausal flushing | off-label use | 198436008 | |
Fibromyalgia | off-label use | 203082005 | DOID:631 |
Seasonal affective disorder | off-label use | 247803002 | |
Suicidal thoughts | contraindication | 6471006 | |
Weight gain finding | contraindication | 8943002 | |
Sinus tachycardia | contraindication | 11092001 | |
Hypercholesterolemia | contraindication | 13644009 | |
Bipolar disorder | contraindication | 13746004 | DOID:3312 |
Neuroleptic malignant syndrome | contraindication | 15244003 | DOID:14464 |
Senile dementia | contraindication | 15662003 | |
Agranulocytosis | contraindication | 17182001 | DOID:12987 |
Lowered convulsive threshold | contraindication | 19260006 | |
Cirrhosis of liver | contraindication | 19943007 | DOID:5082 |
Myocardial infarction | contraindication | 22298006 | DOID:5844 |
Hypovolemia | contraindication | 28560003 | |
Orthostatic hypotension | contraindication | 28651003 | |
Dehydration | contraindication | 34095006 | |
Upper gastrointestinal hemorrhage | contraindication | 37372002 | |
Conduction disorder of the heart | contraindication | 44808001 | |
Low blood pressure | contraindication | 45007003 | |
Bradycardia | contraindication | 48867003 | |
Syndrome of inappropriate vasopressin secretion | contraindication | 55004003 | DOID:3401 |
Paralytic ileus | contraindication | 55525008 | DOID:8442 |
Hyperlipidemia | contraindication | 55822004 | DOID:1168 |
Anorexia nervosa | contraindication | 56882008 | DOID:8689 |
Abnormal sexual function | contraindication | 56925008 | |
Hepatic failure | contraindication | 59927004 | |
Cerebrovascular disease | contraindication | 62914000 | DOID:6713 |
Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Hyperglycemia | contraindication | 80394007 | DOID:4195 |
Heart failure | contraindication | 84114007 | DOID:6000 |
Epilepsy | contraindication | 84757009 | DOID:1826 |
Leukopenia | contraindication | 84828003 | DOID:615 |
Hyponatremia | contraindication | 89627008 | |
Tardive dyskinesia | contraindication | 102449007 | |
Seizure disorder | contraindication | 128613002 | |
Liver function tests abnormal | contraindication | 166603001 | |
Cerebrovascular accident | contraindication | 230690007 | |
Mania | contraindication | 231494001 | |
Hypomania | contraindication | 231496004 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Metabolic syndrome X | contraindication | 237602007 | DOID:14221 |
Hyperprolactinemia | contraindication | 237662005 | DOID:12700 |
Transient ischemic attack | contraindication | 266257000 | DOID:224 |
Esophageal dysmotility | contraindication | 266434009 | DOID:9192 |
Benign prostatic hyperplasia | contraindication | 266569009 | |
Hypertriglyceridemia | contraindication | 302870006 | |
Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
Serotonin syndrome | contraindication | 371089000 | |
At risk for aspiration | contraindication | 371736008 | |
Angle-closure glaucoma | contraindication | 392291006 | DOID:13550 |
Myocardial ischemia | contraindication | 414795007 | DOID:3393 |
Obesity | contraindication | 414916001 | DOID:9970 |
Carcinoma of female breast | contraindication | 447782002 | |
Smokes tobacco daily | contraindication | 449868002 |
Species | Use | Relation |
---|---|---|
Dogs | Separation anxiety | Indication |
Product | Applicant | Ingredients |
---|---|---|
Reconcile | Pegasus Laboratories Inc. | 1 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 9.32 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Sodium-dependent serotonin transporter | Transporter | INHIBITOR | Kd | 9.09 | WOMBAT-PK | CHEMBL | |||
Alpha-2A adrenergic receptor | GPCR | Ki | 8.20 | CHEMBL | |||||
Sigma non-opioid intracellular receptor 1 | Membrane receptor | IC50 | 6.07 | CHEMBL | |||||
Potassium voltage-gated channel subfamily H member 2 | Ion channel | IC50 | 6.16 | WOMBAT-PK | |||||
Sodium-dependent noradrenaline transporter | Transporter | Kd | 6.62 | WOMBAT-PK | |||||
5-hydroxytryptamine receptor 2A | GPCR | Ki | 6.61 | WOMBAT-PK | |||||
5-hydroxytryptamine receptor 2B | GPCR | ANTAGONIST | Ki | 5.30 | IUPHAR | ||||
5-hydroxytryptamine receptor 2C | GPCR | Ki | 6.40 | WOMBAT-PK | |||||
5-hydroxytryptamine receptor 6 | GPCR | Ki | 6.11 | CHEMBL | |||||
Alpha-1A adrenergic receptor | GPCR | Ki | 5.70 | PDSP | |||||
Alpha-2B adrenergic receptor | GPCR | Ki | 6.16 | DRUG MATRIX | |||||
D(3) dopamine receptor | GPCR | Ki | 5.70 | WOMBAT-PK | |||||
Histamine H1 receptor | GPCR | Ki | 5.96 | WOMBAT-PK | |||||
Muscarinic acetylcholine receptor M1 | GPCR | Ki | 6.05 | WOMBAT-PK | |||||
Muscarinic acetylcholine receptor M2 | GPCR | Ki | 5.57 | PDSP | |||||
Muscarinic acetylcholine receptor M3 | GPCR | Ki | 6 | WOMBAT-PK | |||||
Muscarinic acetylcholine receptor M4 | GPCR | Ki | 5.54 | PDSP | |||||
Muscarinic acetylcholine receptor M5 | GPCR | Ki | 5.57 | PDSP | |||||
Sodium-dependent dopamine transporter | Transporter | Kd | 5.44 | WOMBAT-PK | |||||
Cytochrome P450 2D6 | Enzyme | IC50 | 6.16 | DRUG MATRIX | |||||
Acetylcholinesterase | Enzyme | IC50 | 6.89 | CHEMBL | |||||
Potassium channel subfamily K member 2 | Ion channel | IC50 | 4.85 | CHEMBL | |||||
Histamine H3 receptor | GPCR | Ki | 5.14 | CHEMBL | |||||
Equilibrative nucleoside transporter 4 | Transporter | INHIBITOR | Ki | 4.64 | IUPHAR | ||||
Beta-1 adrenergic receptor | GPCR | Ki | 5.36 | WOMBAT-PK | |||||
Sodium-dependent serotonin transporter | Transporter | Ki | 8.70 | CHEMBL | |||||
Sodium-dependent dopamine transporter | Transporter | Ki | 6.11 | CHEMBL | |||||
5-hydroxytryptamine receptor 2A | GPCR | ANTAGONIST | Ki | 6.50 | IUPHAR | ||||
Sigma non-opioid intracellular receptor 1 | Membrane receptor | Ki | 6.62 | CHEMBL | |||||
Transporter | Transporter | Ki | 6.84 | CHEMBL | |||||
Sodium-dependent dopamine transporter | Transporter | Ki | 7.97 | CHEMBL | |||||
Sodium-dependent noradrenaline transporter | Transporter | Ki | 7.07 | CHEMBL | |||||
5-hydroxytryptamine receptor 2C | GPCR | Ki | 6.96 | CHEMBL | |||||
5-hydroxytryptamine receptor 6 | GPCR | ANTAGONIST | Ki | 5.80 | IUPHAR | ||||
Transporter | Transporter | Ki | 6.80 | CHEMBL | |||||
Serotonin 1 (5-HT1) receptor | GPCR | IC50 | 7.82 | CHEMBL | |||||
Adrenergic receptor alpha-2 | GPCR | Ki | 5.72 | CHEMBL | |||||
Adrenergic receptor alpha-1 | GPCR | Ki | 6.22 | CHEMBL | |||||
Potassium voltage-gated channel subfamily C member 1 | Ion channel | IC50 | 4.88 | CHEMBL | |||||
G protein-activated inward rectifier potassium channel 2 | Ion channel | GATING INHIBITOR | IC50 | 4.80 | IUPHAR | ||||
Sigma intracellular receptor 2 | Unclassified | Ki | 4.79 | CHEMBL |
ID | Source |
---|---|
D00326 | KEGG_DRUG |
56296-78-7 | SECONDARY_CAS_RN |
4019389 | VANDF |
4019761 | VANDF |
C0016365 | UMLSCUI |
CHEBI:5118 | CHEBI |
RFX | PDB_CHEM_ID |
CHEMBL1201082 | ChEMBL_ID |
CHEMBL153036 | ChEMBL_ID |
CHEMBL41 | ChEMBL_ID |
DB00472 | DRUGBANK_ID |
D005473 | MESH_DESCRIPTOR_UI |
3386 | PUBCHEM_CID |
203 | IUPHAR_LIGAND_ID |
3883 | INN_ID |
01K63SUP8D | UNII |
227224 | RXNORM |
17711 | MMSL |
28237 | MMSL |
37675 | MMSL |
4091 | MMSL |
41730 | MMSL |
4746 | MMSL |
d00236 | MMSL |
001514 | NDDF |
004613 | NDDF |
372767007 | SNOMEDCT_US |
53640004 | SNOMEDCT_US |
75115009 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Symbyax | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0002-3230 | CAPSULE | 25 mg | ORAL | NDA | 34 sections |
Symbyax | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0002-3231 | CAPSULE | 25 mg | ORAL | NDA | 34 sections |
Fluoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-0807 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 32 sections |
Fluoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-0807 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 32 sections |
Fluoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-5262 | TABLET, FILM COATED | 60 mg | ORAL | ANDA | 32 sections |
Fluoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-5262 | TABLET, FILM COATED | 60 mg | ORAL | ANDA | 32 sections |
Olanzapine and Fluoxetine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-5503 | CAPSULE | 25 mg | ORAL | ANDA | 32 sections |
Olanzapine and Fluoxetine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-5504 | CAPSULE | 25 mg | ORAL | ANDA | 32 sections |
Olanzapine and Fluoxetine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-5505 | CAPSULE | 50 mg | ORAL | ANDA | 32 sections |
Olanzapine and Fluoxetine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-5506 | CAPSULE | 25 mg | ORAL | ANDA | 32 sections |
Olanzapine and Fluoxetine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-5507 | CAPSULE | 50 mg | ORAL | ANDA | 32 sections |
Fluoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-7188 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 32 sections |
Fluoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-7188 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 32 sections |
Fluoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-7198 | CAPSULE | 40 mg | ORAL | ANDA | 31 sections |
Fluoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-7198 | CAPSULE | 40 mg | ORAL | ANDA | 31 sections |
Fluoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0121-0721 | SOLUTION | 20 mg | ORAL | ANDA | 33 sections |
Fluoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0121-0721 | SOLUTION | 20 mg | ORAL | ANDA | 33 sections |
Fluoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0121-4721 | SOLUTION | 20 mg | ORAL | ANDA | 33 sections |
Fluoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0121-4721 | SOLUTION | 20 mg | ORAL | ANDA | 33 sections |
Fluoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-1384 | CAPSULE | 10 mg | ORAL | ANDA | 33 sections |
Fluoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-7625 | CAPSULE | 20 mg | ORAL | ANDA | 32 sections |
Fluoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-7625 | CAPSULE | 20 mg | ORAL | ANDA | 32 sections |
Fluoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-7638 | CAPSULE | 10 mg | ORAL | ANDA | 32 sections |
Fluoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8093 | CAPSULE | 10 mg | ORAL | ANDA | 32 sections |
Fluoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8093 | CAPSULE | 10 mg | ORAL | ANDA | 32 sections |
Fluoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8183 | CAPSULE | 40 mg | ORAL | ANDA | 33 sections |
Prozac | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0777-3104 | CAPSULE | 10 mg | ORAL | NDA | 35 sections |
Prozac | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0777-3105 | CAPSULE | 20 mg | ORAL | NDA | 35 sections |
Prozac | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0777-3107 | CAPSULE | 40 mg | ORAL | NDA | 35 sections |
Fluoxetine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-2822 | CAPSULE | 20 mg | ORAL | ANDA | 31 sections |