fluconazole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
systemic antifungal agents, miconazole derivatives 1187 86386-73-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • fluconazole
  • difluconazole
  • flunazol
  • diflucan
Triazole antifungal agent that is used to treat oropharyngeal CANDIDIASIS and cryptococcal MENINGITIS in AIDS.
  • Molecular weight: 306.28
  • Formula: C13H12F2N6O
  • CLOGP: 0.10
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 1
  • TPSA: 81.65
  • ALOGS: -2.34
  • ROTB: 5
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.20 g O
0.20 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 6 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 75 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 9.33 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 90 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.75 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.31 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.89 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 30 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Jan. 29, 1990 FDA PFIZER

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 610.85 9.91 812 93063 117637 63277510
Drug interaction 382.84 9.91 962 92913 228169 63166978
Candida infection 370.72 9.91 319 93556 28032 63367115
Mucosal inflammation 266.94 9.91 338 93537 46590 63348557
Pemphigus 235.83 9.91 8 93867 183718 63211429
Sepsis 215.84 9.91 604 93271 152519 63242628
Hand deformity 208.03 9.91 6 93869 159451 63235696
Thrombocytopenia 207.91 9.91 591 93284 150566 63244581
Glossodynia 206.77 9.91 15 93860 178861 63216286
Fungal infection 205.60 9.91 263 93612 36611 63358536
Cytokine release syndrome 205.47 9.91 170 93705 14144 63381003
Systemic lupus erythematosus 204.76 9.91 32 93843 208886 63186261
Multiple organ dysfunction syndrome 202.01 9.91 327 93548 56425 63338722
Synovitis 199.05 9.91 22 93853 186896 63208251
Stevens-Johnson syndrome 190.53 9.91 209 93666 24741 63370406
Pancytopenia 185.09 9.91 429 93446 96504 63298643
Oral candidiasis 167.23 9.91 187 93688 22611 63372536
Arthropathy 160.73 9.91 73 93802 234719 63160428
Abdominal discomfort 159.34 9.91 144 93731 320741 63074406
Arthralgia 158.63 9.91 383 93492 569327 62825820
Contraindicated product administered 158.07 9.91 62 93813 217586 63177561
Joint swelling 158.05 9.91 151 93724 327515 63067632
Therapeutic product effect decreased 155.95 9.91 46 93829 193141 63202006
Septic shock 153.41 9.91 318 93557 66311 63328836
Neutropenia 146.63 9.91 579 93296 174426 63220721
Platelet count decreased 141.45 9.91 435 93440 115687 63279460
Cytomegalovirus infection 140.39 9.91 164 93711 20788 63374359
Wound 139.04 9.91 35 93840 163228 63231919
Pyrexia 138.85 9.91 1177 92698 469301 62925846
Female genital tract fistula 136.97 9.91 103 93772 7456 63387691
Alopecia 131.01 9.91 185 93690 337351 63057796
Graft versus host disease 128.91 9.91 95 93780 6668 63388479
Maternal exposure during pregnancy 123.93 9.91 87 93788 219975 63175172
Pathogen resistance 117.76 9.91 88 93787 6310 63388837
Rheumatoid arthritis 116.55 9.91 122 93753 253697 63141450
Aspergillus infection 115.90 9.91 96 93779 7997 63387150
Pericarditis 114.38 9.91 27 93848 131552 63263595
Swelling 113.87 9.91 144 93731 275234 63119913
Neutrophil count decreased 111.31 9.91 253 93622 56153 63338994
Vaginal discharge 109.18 9.91 98 93777 9100 63386047
Mucormycosis 108.51 9.91 62 93813 2809 63392338
Toxic epidermal necrolysis 108.40 9.91 159 93716 25175 63369972
Drug intolerance 107.47 9.91 182 93693 308479 63086668
Discomfort 101.24 9.91 61 93814 167313 63227834
Helicobacter infection 101.09 9.91 10 93865 92775 63302372
Drug resistance 96.77 9.91 143 93732 22790 63372357
Sinusitis fungal 95.62 9.91 49 93826 1782 63393365
Deep vein thrombosis 94.73 9.91 306 93569 83494 63311653
Musculoskeletal stiffness 91.35 9.91 83 93792 184535 63210612
Abortion spontaneous 90.15 9.91 209 93666 46986 63348161
Systemic candida 88.88 9.91 57 93818 3188 63391959
Enterococcal infection 86.08 9.91 80 93795 7768 63387379
Salpingo-oophorectomy unilateral 84.80 9.91 36 93839 845 63394302
Bronchopulmonary aspergillosis 83.30 9.91 82 93793 8553 63386594
Immune reconstitution inflammatory syndrome 82.64 9.91 70 93805 6014 63389133
Fixed eruption 78.24 9.91 37 93838 1127 63394020
Infusion related reaction 76.35 9.91 155 93720 245366 63149781
Peripheral swelling 75.99 9.91 176 93699 265766 63129381
Fall 75.61 9.91 311 93564 392023 63003124
Oesophageal candidiasis 74.56 9.91 64 93811 5599 63389548
Nasopharyngitis 72.86 9.91 168 93707 254089 63141058
Fungaemia 72.81 9.91 45 93830 2358 63392789
Fatigue 72.13 9.91 905 92970 887123 62508024
Mouth ulceration 71.90 9.91 154 93721 32830 63362317
Sputum increased 71.86 9.91 45 93830 2414 63392733
Irritable bowel syndrome 71.43 9.91 17 93858 82395 63312752
Cytomegalovirus viraemia 70.65 9.91 62 93813 5587 63389560
Acute myeloid leukaemia 69.60 9.91 105 93770 17042 63378105
Vaginal flatulence 69.02 9.91 49 93826 3244 63391903
Skin candida 68.68 9.91 38 93837 1617 63393530
Impaired healing 66.86 9.91 34 93841 102508 63292639
Proctitis 66.62 9.91 59 93816 5382 63389765
Plasma cell myeloma 66.38 9.91 157 93718 35748 63359399
Intentional overdose 62.89 9.91 16 93859 74136 63321011
Hepatic enzyme increased 62.65 9.91 128 93747 202200 63192947
Laryngitis fungal 61.72 9.91 18 93857 129 63395018
Embolism venous 61.68 9.91 45 93830 3109 63392038
Respiratory symptom 61.51 9.91 46 93829 3301 63391846
Disseminated mucormycosis 61.35 9.91 19 93856 171 63394976
Infective aneurysm 61.29 9.91 23 93852 386 63394761
Aplastic anaemia 60.95 9.91 73 93802 9496 63385651
Torsade de pointes 60.33 9.91 86 93789 13265 63381882
White blood cell count decreased 59.72 9.91 381 93494 138723 63256424
Drug ineffective 59.59 9.91 1139 92736 1043626 62351521
Neutropenic sepsis 58.83 9.91 95 93780 16343 63378804
Anaemia 58.40 9.91 677 93198 292753 63102394
Folliculitis 58.07 9.91 16 93859 70301 63324846
Acute graft versus host disease in skin 58.06 9.91 45 93830 3407 63391740
Respiratory failure 57.46 9.91 300 93575 101558 63293589
Bacterial sepsis 56.78 9.91 47 93828 3911 63391236
Colitis 55.54 9.91 178 93697 48350 63346797
Immune effector cell-associated neurotoxicity syndrome 55.06 9.91 37 93838 2240 63392907
Treatment failure 55.01 9.91 134 93741 198909 63196238
Pneumonia fungal 54.86 9.91 53 93822 5402 63389745
Bone marrow failure 54.06 9.91 128 93747 29162 63365985
Renal failure 53.47 9.91 327 93548 117325 63277822
Pseudomonas infection 53.29 9.91 74 93801 11139 63384008
Hypersensitivity 53.26 9.91 237 93638 292448 63102699
Foetal death 52.99 9.91 73 93802 10907 63384240
Dermatitis bullous 52.71 9.91 64 93811 8444 63386703
Vulvovaginal candidiasis 52.56 9.91 41 93834 3134 63392013
Pain 51.66 9.91 778 93097 739850 62655297
Blood lactate dehydrogenase increased 51.62 9.91 109 93766 23007 63372140
Bacteraemia 51.18 9.91 92 93783 17256 63377891
Suicide attempt 50.04 9.91 14 93861 60904 63334243
Pulmonary embolism 49.71 9.91 319 93556 116365 63278782
Fungal sepsis 49.54 9.91 28 93847 1242 63393905
Hypomagnesaemia 49.20 9.91 122 93753 28615 63366532
Uterine perforation 49.15 9.91 56 93819 6907 63388240
Chronic sinusitis 48.41 9.91 76 93799 12767 63382380
Cytomegalovirus test positive 47.86 9.91 38 93837 2980 63392167
Blood alkaline phosphatase increased 46.82 9.91 155 93720 42812 63352335
Fibromyalgia 46.28 9.91 31 93844 80389 63314758
Drug level increased 45.97 9.91 103 93772 22633 63372514
Agranulocytosis 45.48 9.91 109 93766 25025 63370122
Cystitis haemorrhagic 45.16 9.91 42 93833 4081 63391066
Acute generalised exanthematous pustulosis 45.09 9.91 68 93807 11031 63384116
Blood bilirubin increased 45.04 9.91 139 93736 37001 63358146
Psoriatic arthropathy 44.23 9.91 42 93833 91478 63303669
International normalised ratio increased 44.09 9.91 160 93715 46265 63348882
Dysphagia 43.96 9.91 252 93623 88333 63306814
Diastolic dysfunction 43.92 9.91 51 93824 6420 63388727
Intentional product use issue 43.89 9.91 76 93799 127816 63267331
Injection site pain 43.76 9.91 78 93797 129722 63265425
Neurotoxicity 43.75 9.91 85 93790 16905 63378242
Therapeutic product effect incomplete 43.21 9.91 74 93801 124982 63270165
Radiculopathy 42.69 9.91 58 93817 8553 63386594
Aspartate aminotransferase increased 42.33 9.91 253 93622 90024 63305123
Knee arthroplasty 41.75 9.91 14 93861 54192 63340955
Hepatic function abnormal 41.38 9.91 135 93740 37007 63358140
Cryptococcosis 41.10 9.91 24 93851 1133 63394014
Mobility decreased 40.67 9.91 73 93802 121086 63274061
Acute kidney injury 40.64 9.91 580 93295 262835 63132312
Staphylococcal infection 39.87 9.91 143 93732 41113 63354034
Cutaneous coccidioidomycosis 39.80 9.91 9 93866 18 63395129
Tumour lysis syndrome 39.29 9.91 57 93818 8933 63386214
BK virus infection 39.04 9.91 35 93840 3244 63391903
Drug ineffective for unapproved indication 39.02 9.91 125 93750 33938 63361209
Acute graft versus host disease 38.95 9.91 40 93835 4388 63390759
Ill-defined disorder 38.95 9.91 38 93837 81717 63313430
Device related infection 38.67 9.91 98 93777 23294 63371853
Jarisch-Herxheimer reaction 38.27 9.91 16 93859 361 63394786
Geotrichum infection 37.91 9.91 17 93858 457 63394690
Adverse event 37.60 9.91 27 93848 67532 63327615
Rash erythematous 37.44 9.91 143 93732 42367 63352780
Cholecystitis chronic 37.24 9.91 60 93815 10301 63384846
Klebsiella infection 36.98 9.91 54 93821 8512 63386635
Contusion 36.90 9.91 107 93768 149937 63245210
Alanine aminotransferase increased 36.67 9.91 271 93604 103499 63291648
Tonsillar haemorrhage 36.66 9.91 14 93861 247 63394900
Epstein-Barr virus infection 36.58 9.91 52 93823 7998 63387149
Gastrointestinal fungal infection 36.02 9.91 15 93860 335 63394812
Immunosuppressant drug level increased 35.93 9.91 35 93840 3603 63391544
Hypokalaemia 35.50 9.91 269 93606 103535 63291612
Enterobacter infection 35.23 9.91 28 93847 2199 63392948
Drug reaction with eosinophilia and systemic symptoms 35.04 9.91 120 93755 33716 63361431
Vaginal infection 34.81 9.91 49 93826 7469 63387678
Oral disorder 34.21 9.91 53 93822 8801 63386346
Blood cholesterol increased 34.00 9.91 54 93821 93978 63301169
Rash maculo-papular 33.80 9.91 114 93761 31782 63363365
Gamma-glutamyltransferase increased 33.77 9.91 119 93756 33912 63361235
Nasal polyps 33.53 9.91 43 93832 5996 63389151
Haemophagocytic lymphohistiocytosis 33.47 9.91 58 93817 10569 63384578
Loss of personal independence in daily activities 33.21 9.91 58 93817 97232 63297915
Constipation 32.98 9.91 491 93384 224452 63170695
Injection site erythema 32.77 9.91 45 93830 83129 63312018
Electrocardiogram QT prolonged 32.64 9.91 174 93701 59356 63335791
Dizziness 32.54 9.91 444 93431 429481 62965666
Product use issue 32.48 9.91 192 93683 220328 63174819
Shock haemorrhagic 32.47 9.91 55 93820 9840 63385307
Type 2 diabetes mellitus 32.42 9.91 28 93847 63840 63331307
Hepatic failure 32.27 9.91 121 93754 35535 63359612
Acute myeloid leukaemia recurrent 31.39 9.91 23 93852 1600 63393547
Neuropathy peripheral 31.05 9.91 280 93595 113387 63281760
Cholestasis 31.02 9.91 105 93770 29329 63365818
Congenital absence of cranial vault 30.96 9.91 7 93868 14 63395133
Condition aggravated 30.93 9.91 414 93461 401803 62993344
Clostridium difficile colitis 30.76 9.91 83 93792 20486 63374661
Hip arthroplasty 30.75 9.91 16 93859 47630 63347517
Disseminated intravascular coagulation 30.65 9.91 79 93796 18972 63376175
Inappropriate schedule of product administration 30.30 9.91 68 93807 103897 63291250
Breast cancer 30.13 9.91 17 93858 48366 63346781
Dysbiosis 30.11 9.91 18 93857 888 63394259
Erythema multiforme 30.09 9.91 54 93821 10115 63385032
Meningitis cryptococcal 30.04 9.91 21 93854 1356 63393791
Toxic neuropathy 29.99 9.91 14 93861 414 63394733
Hyperbilirubinaemia 29.62 9.91 57 93818 11257 63383890
Tricuspid valve incompetence 29.29 9.91 66 93809 14555 63380592
Nasal abscess 29.13 9.91 11 93864 188 63394959
Chronic graft versus host disease 29.07 9.91 29 93846 3073 63392074
Toxoplasmosis 28.14 9.91 21 93854 1502 63393645
Leukopenia 27.96 9.91 203 93672 77087 63318060
Fungal oesophagitis 27.94 9.91 16 93859 728 63394419
Injection site swelling 27.82 9.91 18 93857 47554 63347593
Symmetrical drug-related intertriginous and flexural exanthema 27.81 9.91 14 93861 490 63394657
Drug abuse 27.81 9.91 40 93835 72478 63322669
Staphylococcal sepsis 27.77 9.91 46 93829 8082 63387065
Engraftment syndrome 27.71 9.91 14 93861 494 63394653
Sinus polyp 27.61 9.91 13 93862 392 63394755
Oral fungal infection 27.33 9.91 28 93847 3063 63392084
Enterococcal sepsis 27.21 9.91 20 93855 1398 63393749
Pneumonia 27.18 9.91 875 93000 455892 62939255
Gastrointestinal disorder 27.14 9.91 101 93774 131138 63264009
Abscess neck 26.69 9.91 15 93860 658 63394489
Blood immunoglobulin M increased 26.27 9.91 18 93857 1125 63394022
Hypertension 26.26 9.91 275 93600 279028 63116119
Blood immunoglobulin A decreased 26.23 9.91 19 93856 1298 63393849
Renal tubular acidosis 26.18 9.91 21 93854 1671 63393476
Puerperal pyrexia 26.14 9.91 7 93868 35 63395112
Emphysema 26.09 9.91 53 93822 10885 63384262
Soft tissue neoplasm 25.93 9.91 8 93867 71 63395076
Basal cell carcinoma 25.83 9.91 5 93870 27986 63367161
Swollen tongue 25.81 9.91 111 93764 34689 63360458
Sleep disorder 25.74 9.91 51 93824 81515 63313632
Eosinophilia 25.60 9.91 83 93792 22673 63372474
Arthritis 25.45 9.91 87 93788 115834 63279313
Candida sepsis 25.44 9.91 19 93856 1361 63393786
Respiratory tract infection fungal 25.41 9.91 13 93862 471 63394676
Wrong technique in product usage process 25.30 9.91 33 93842 62307 63332840
Congestive cardiomyopathy 25.29 9.91 38 93837 6144 63389003
Septic embolus 25.17 9.91 16 93859 881 63394266
Accidental exposure to product 25.07 9.91 5 93870 27400 63367747
Encephalitis fungal 24.93 9.91 7 93868 43 63395104
Stenotrophomonas infection 24.85 9.91 22 93853 2005 63393142
Enterococcal bacteraemia 24.50 9.91 19 93856 1440 63393707
Sepsis syndrome 24.45 9.91 16 93859 926 63394221
Toxicity to various agents 24.24 9.91 241 93634 247009 63148138
Staphylococcal bacteraemia 24.07 9.91 35 93840 5495 63389652
Blood pressure increased 23.90 9.91 141 93734 161921 63233226
Diverticulum 23.88 9.91 54 93821 11937 63383210
Blood pressure systolic increased 23.79 9.91 21 93854 47376 63347771
Neutropenic colitis 23.75 9.91 26 93849 3069 63392078
Liver abscess 23.70 9.91 25 93850 2829 63392318
C-reactive protein abnormal 23.65 9.91 20 93855 46076 63349071
Pleural effusion 23.64 9.91 226 93649 92984 63302163
Fungal endocarditis 23.62 9.91 10 93865 233 63394914
Failure to thrive 23.61 9.91 40 93835 7158 63387989
Adrenal insufficiency 23.56 9.91 69 93806 17846 63377301
Acute graft versus host disease in intestine 23.50 9.91 20 93855 1729 63393418
Focal myositis 23.49 9.91 6 93869 24 63395123
Blast cell count increased 23.48 9.91 12 93863 434 63394713
Pain in extremity 23.41 9.91 347 93528 331139 63064008
Systemic mycosis 23.23 9.91 17 93858 1180 63393967
Venoocclusive liver disease 23.11 9.91 32 93843 4803 63390344
Cytopenia 22.83 9.91 52 93823 11549 63383598
Stem cell transplant 22.79 9.91 20 93855 1802 63393345
Antithrombin III decreased 22.79 9.91 10 93865 255 63394892
Live birth 22.78 9.91 5 93870 25625 63369522
Myelosuppression 22.76 9.91 82 93793 23621 63371526
Temperature regulation disorder 22.71 9.91 36 93839 6096 63389051
Encephalopathy 22.63 9.91 115 93760 38505 63356642
Joint neoplasm 22.60 9.91 7 93868 63 63395084
Nail infection 22.57 9.91 23 93852 2500 63392647
Therapeutic response decreased 22.56 9.91 35 93840 61490 63333657
Nervous system disorder 22.53 9.91 70 93805 18696 63376451
Odynophagia 22.46 9.91 40 93835 7446 63387701
Toxic skin eruption 22.37 9.91 55 93820 12830 63382317
Resorption bone increased 22.28 9.91 17 93858 1257 63393890
Malaise 22.14 9.91 458 93417 415496 62979651
Transplant rejection 21.97 9.91 49 93826 10731 63384416
Diabetic macroangiopathy 21.84 9.91 8 93867 125 63395022
Plasma cell leukaemia 21.82 9.91 16 93859 1114 63394033
Coccidioidomycosis 21.73 9.91 15 93860 949 63394198
Drug eruption 21.65 9.91 92 93783 28602 63366545
Fat necrosis 21.64 9.91 13 93862 647 63394500
Feeling abnormal 21.41 9.91 130 93745 148262 63246885
Oral pain 21.39 9.91 91 93784 28303 63366844
Poor peripheral circulation 21.29 9.91 27 93848 3722 63391425
Weight increased 21.29 9.91 265 93610 260527 63134620
Incorrect dose administered 21.15 9.91 35 93840 59933 63335214
Tongue coated 21.14 9.91 17 93858 1358 63393789
Acinetobacter infection 21.06 9.91 18 93857 1565 63393582
Urinary tract infection fungal 21.02 9.91 13 93862 682 63394465
Oesophagitis 20.89 9.91 59 93816 14949 63380198
Disseminated cryptococcosis 20.88 9.91 11 93864 424 63394723
Long QT syndrome 20.86 9.91 25 93850 3254 63391893
Acute lymphocytic leukaemia 20.82 9.91 22 93853 2494 63392653
Injury 20.80 9.91 182 93693 73065 63322082
Viral haemorrhagic cystitis 20.72 9.91 14 93861 855 63394292
Gastrointestinal mucormycosis 20.67 9.91 9 93866 225 63394922
Cystic fibrosis related diabetes 20.57 9.91 6 93869 43 63395104
Disease recurrence 20.48 9.91 89 93786 27941 63367206
Thrombotic microangiopathy 20.41 9.91 47 93828 10514 63384633
Overgrowth fungal 20.36 9.91 7 93868 90 63395057
Candida test positive 20.34 9.91 14 93861 882 63394265
Hysterectomy 20.29 9.91 44 93831 9455 63385692
Anhedonia 20.29 9.91 48 93827 10926 63384221
Lung infiltration 20.27 9.91 57 93818 14406 63380741
Delayed graft function 20.04 9.91 15 93860 1078 63394069
Graft versus host disease in skin 19.89 9.91 23 93852 2882 63392265
Medication error 19.89 9.91 29 93846 52255 63342892
Emotional distress 19.83 9.91 98 93777 32451 63362696
Engraft failure 19.71 9.91 10 93865 356 63394791
Livedo reticularis 19.66 9.91 21 93854 2411 63392736
Herpes simplex 19.64 9.91 40 93835 8231 63386916
Renal abscess 19.49 9.91 13 93862 777 63394370
Adverse drug reaction 19.48 9.91 57 93818 79657 63315490
Leukocytosis 19.45 9.91 83 93792 25852 63369295
Status epilepticus 19.39 9.91 58 93817 15175 63379972
Philadelphia positive acute lymphocytic leukaemia 19.38 9.91 5 93870 21 63395126
Gastritis fungal 19.37 9.91 7 93868 105 63395042
Prothrombin time shortened 19.34 9.91 19 93856 1976 63393171
Blood pressure fluctuation 19.33 9.91 24 93851 46293 63348854
Leukoencephalopathy 19.31 9.91 28 93847 4385 63390762
Hiatus hernia 19.31 9.91 73 93802 21521 63373626
Graft versus host disease in lung 19.30 9.91 10 93865 372 63394775
Post transplant lymphoproliferative disorder 19.28 9.91 30 93845 5001 63390146
Pulmonary infarction 19.23 9.91 22 93853 2725 63392422
Mediastinal effusion 19.18 9.91 6 93869 56 63395091
Generalised oedema 18.99 9.91 59 93816 15759 63379388
Tongue blistering 18.94 9.91 17 93858 1578 63393569
Escherichia infection 18.60 9.91 51 93824 12703 63382444
Respiratory moniliasis 18.60 9.91 8 93867 194 63394953
Pulmonary haemorrhage 18.58 9.91 36 93839 7145 63388002
Renal impairment 18.49 9.91 206 93669 88149 63306998
Skin exfoliation 18.44 9.91 118 93757 42984 63352163
HIV infection 18.35 9.91 10 93865 413 63394734
Abdominal pain upper 18.29 9.91 206 93669 206238 63188909
Injection site bruising 18.25 9.91 21 93854 41889 63353258
Pseudomonal sepsis 18.13 9.91 20 93855 2381 63392766
Necrotising enterocolitis neonatal 18.12 9.91 8 93867 207 63394940
Liver injury 18.11 9.91 39 93836 60481 63334666
Food allergy 18.05 9.91 47 93828 11354 63383793
Mucosal disorder 18.01 9.91 19 93856 2150 63392997
Blastomycosis 17.90 9.91 9 93866 314 63394833
Graft versus host disease in gastrointestinal tract 17.87 9.91 23 93852 3218 63391929
Diffuse large B-cell lymphoma 17.79 9.91 34 93841 6678 63388469
Coagulation factor V level decreased 17.77 9.91 9 93866 319 63394828
Poikiloderma 17.64 9.91 8 93867 221 63394926
Aeromonas infection 17.53 9.91 6 93869 76 63395071
Shock 17.52 9.91 75 93800 23388 63371759
Growth failure 17.49 9.91 9 93866 330 63394817
Septic pulmonary embolism 17.12 9.91 6 93869 82 63395065
Pharyngeal stenosis 17.08 9.91 4 93871 10 63395137
Hepatic artery aneurysm 17.08 9.91 4 93871 10 63395137
General physical health deterioration 17.05 9.91 203 93672 201199 63193948
Cerebral toxoplasmosis 17.00 9.91 13 93862 965 63394182
Hepatitis acute 16.98 9.91 40 93835 9080 63386067
Petechiae 16.83 9.91 52 93823 13845 63381302
Ureaplasma infection 16.76 9.91 11 93864 640 63394507
Swelling face 16.64 9.91 155 93720 63320 63331827
Nightmare 16.55 9.91 4 93871 19190 63375957
Epstein-Barr virus associated lymphoproliferative disorder 16.46 9.91 17 93858 1877 63393270
Blood culture positive 16.45 9.91 27 93848 4708 63390439
Acid base balance abnormal 16.41 9.91 8 93867 261 63394886
Fibrin degradation products increased 16.38 9.91 7 93868 167 63394980
Stoma site candida 16.30 9.91 4 93871 13 63395134
Feeling hot 16.30 9.91 31 93844 50323 63344824
Blood immunoglobulin G increased 16.26 9.91 19 93856 2408 63392739
Arteritis infective 16.24 9.91 5 93870 44 63395103
Red blood cell sedimentation rate increased 16.14 9.91 25 93850 43957 63351190
Restlessness 16.09 9.91 12 93863 29441 63365706
Metabolic acidosis 16.08 9.91 118 93757 44951 63350196
Product dose omission issue 15.93 9.91 247 93628 234066 63161081
Inflammation 15.93 9.91 65 93810 82208 63312939
Angioimmunoblastic T-cell lymphoma 15.92 9.91 6 93869 102 63395045
Acquired macroglossia 15.86 9.91 7 93868 181 63394966
Night sweats 15.85 9.91 30 93845 48784 63346363
Hiccups 15.84 9.91 18 93857 2213 63392934
Lower limb fracture 15.83 9.91 8 93867 24213 63370934
Vulvovaginal mycotic infection 15.76 9.91 29 93846 5537 63389610
Mucosal erosion 15.76 9.91 15 93860 1501 63393646
Purpura senile 15.69 9.91 10 93865 553 63394594
PRIDE syndrome 15.66 9.91 4 93871 16 63395131
Infective chondritis 15.66 9.91 4 93871 16 63395131
Neural tube defect 15.38 9.91 7 93868 195 63394952
Inhibitory drug interaction 15.37 9.91 20 93855 2829 63392318
Hypoglossal nerve paresis 15.35 9.91 6 93869 113 63395034
Immunodeficiency 15.33 9.91 65 93810 20189 63374958
Refractory anaemia with an excess of blasts 15.16 9.91 9 93866 438 63394709
Oral mucosal blistering 15.15 9.91 29 93846 5704 63389443
Grip strength decreased 15.11 9.91 7 93868 22280 63372867
Respiratory tract haemorrhage 15.00 9.91 9 93866 447 63394700
Blood creatinine increased 14.97 9.91 197 93678 87647 63307500
Disseminated coccidioidomycosis 14.93 9.91 5 93870 59 63395088
Secondary amyloidosis 14.93 9.91 6 93869 122 63395025
Splenic vein thrombosis 14.84 9.91 8 93867 323 63394824
Vulvovaginal pruritus 14.81 9.91 21 93854 3222 63391925
Vulvovaginitis 14.71 9.91 8 93867 329 63394818
Dyspnoea 14.71 9.91 814 93061 660499 62734648
Varicella zoster virus infection 14.70 9.91 19 93856 2670 63392477
Bone erosion 14.68 9.91 4 93871 17713 63377434
Acute sinusitis 14.64 9.91 23 93852 3864 63391283
Leukaemia 14.62 9.91 24 93851 4184 63390963
Rhinorrhoea 14.53 9.91 49 93826 65528 63329619
Sleep apnoea syndrome 14.52 9.91 83 93792 29050 63366097
Acute respiratory distress syndrome 14.44 9.91 71 93804 23463 63371684
Injection site pruritus 14.41 9.91 28 93847 45088 63350059
Upper respiratory tract infection 14.40 9.91 185 93690 81862 63313285
Capillary leak syndrome 14.37 9.91 17 93858 2183 63392964
Systemic inflammatory response syndrome 14.32 9.91 28 93847 5593 63389554
Haemodialysis 14.29 9.91 37 93838 8910 63386237
Joint stiffness 14.25 9.91 25 93850 41844 63353303
Angina bullosa haemorrhagica 14.25 9.91 6 93869 138 63395009
Posterior reversible encephalopathy syndrome 14.18 9.91 57 93818 17288 63377859
Enterocolitis 14.13 9.91 34 93841 7824 63387323
Colitis ulcerative 14.12 9.91 76 93799 26015 63369132
Primary adrenal insufficiency 14.09 9.91 6 93869 142 63395005
Metapneumovirus pneumonia 14.05 9.91 4 93871 26 63395121
Wound infection fungal 14.05 9.91 6 93869 143 63395004
Right ventricular failure 14.02 9.91 4 93871 17184 63377963
Central nervous system lymphoma 14.00 9.91 14 93861 1488 63393659
Post procedural bile leak 13.97 9.91 6 93869 145 63395002
Cushing's syndrome 13.89 9.91 10 93865 677 63394470
Gait disturbance 13.88 9.91 189 93686 182989 63212158
Angiodermatitis 13.78 9.91 5 93870 76 63395071
Leukaemic infiltration extramedullary 13.72 9.91 5 93870 77 63395070
Lichenoid keratosis 13.72 9.91 15 93860 1768 63393379
Acinetobacter test positive 13.60 9.91 5 93870 79 63395068
Duodenal stenosis 13.57 9.91 9 93866 533 63394614
Fracture 13.52 9.91 6 93869 19578 63375569
Oropharyngeal candidiasis 13.51 9.91 12 93863 1099 63394048
Vulvovaginal swelling 13.43 9.91 9 93866 542 63394605
Intentional self-injury 13.35 9.91 11 93864 25676 63369471
Vulvovaginal discomfort 13.31 9.91 17 93858 2361 63392786
Insomnia 13.28 9.91 231 93644 215021 63180126
Fungal test positive 13.27 9.91 9 93866 553 63394594
Road traffic accident 13.27 9.91 21 93854 36611 63358536
Gingival ulceration 13.25 9.91 11 93864 919 63394228
Erythema 13.25 9.91 347 93528 175404 63219743
Staphylococcus test positive 13.24 9.91 22 93853 3874 63391273
Foot deformity 13.20 9.91 13 93862 27840 63367307
Gallbladder disorder 13.14 9.91 59 93816 18783 63376364
Tarsal tunnel syndrome 13.10 9.91 9 93866 565 63394582
Jaundice 13.08 9.91 81 93794 29170 63365977
Dehydration 12.99 9.91 342 93533 173012 63222135
Fungal skin infection 12.98 9.91 24 93851 4598 63390549
Rash morbilliform 12.98 9.91 20 93855 3305 63391842
Abdominal pain 12.98 9.91 544 93331 292912 63102235
Vulvovaginal disorder 12.95 9.91 3 93872 7 63395140
Immunosuppressant drug level decreased 12.91 9.91 11 93864 952 63394195
Herpes simplex oesophagitis 12.80 9.91 6 93869 179 63394968
Cachexia 12.78 9.91 27 93848 5699 63389448
CD4 lymphocytes decreased 12.75 9.91 13 93862 1414 63393733
Heliotrope rash 12.74 9.91 6 93869 181 63394966
Chronic hepatitis C 12.71 9.91 6 93869 182 63394965
Streptococcal sepsis 12.65 9.91 15 93860 1931 63393216
Anencephaly 12.60 9.91 7 93868 300 63394847
Joint dislocation 12.60 9.91 6 93869 18794 63376353
Lymphopenia 12.49 9.91 57 93818 18270 63376877
Pulmonary fibrosis 12.46 9.91 25 93850 39784 63355363
Encephalitis 12.45 9.91 35 93840 8845 63386302
Cushingoid 12.45 9.91 34 93841 8451 63386696
Gallbladder fibrosis 12.41 9.91 3 93872 9 63395138
Eczema 12.36 9.91 86 93789 32205 63362942
Rhinocerebral mucormycosis 12.32 9.91 8 93867 457 63394690
Respiratory syncytial virus infection 12.23 9.91 30 93845 6988 63388159
Skin maceration 12.20 9.91 4 93871 44 63395103
Haemorrhage 12.19 9.91 141 93734 60881 63334266
Skin hyperpigmentation 12.17 9.91 27 93848 5894 63389253
Xanthopsia 12.16 9.91 6 93869 201 63394946
Dermatitis diaper 12.03 9.91 6 93869 206 63394941
Herpes simplex viraemia 12.02 9.91 7 93868 329 63394818
Ileus paralytic 12.00 9.91 23 93852 4528 63390619
Exposure via breast milk 11.98 9.91 15 93860 2042 63393105
Atelectasis 11.91 9.91 63 93812 21420 63373727
Heparin-induced thrombocytopenia 11.89 9.91 23 93852 4559 63390588
Brain oedema 11.88 9.91 47 93828 14148 63380999
Meningitis 11.79 9.91 30 93845 7147 63388000
Memory impairment 11.78 9.91 98 93777 104160 63290987
Acute febrile neutrophilic dermatosis 11.77 9.91 18 93857 2956 63392191
CSF culture positive 11.74 9.91 3 93872 12 63395135
Epidermolysis 11.74 9.91 9 93866 670 63394477
Therapy non-responder 11.74 9.91 65 93810 75836 63319311
Renal tubular disorder 11.71 9.91 17 93858 2665 63392482
Myocardial infarction 11.70 9.91 93 93782 99800 63295347
Out of specification test results 11.67 9.91 5 93870 120 63395027
Subdiaphragmatic abscess 11.66 9.91 4 93871 51 63395096
Urinary tract infection enterococcal 11.56 9.91 17 93858 2696 63392451
Hepatotoxicity 11.55 9.91 94 93781 36947 63358200
Biliary dyskinesia 11.49 9.91 17 93858 2712 63392435
Hypoalbuminaemia 11.47 9.91 41 93834 11764 63383383
Pain in jaw 11.44 9.91 30 93845 43466 63351681
Extremity necrosis 11.43 9.91 13 93862 1600 63393547
Thrombophlebitis 11.42 9.91 22 93853 4346 63390801
Proteus infection 11.42 9.91 11 93864 1117 63394030
Vomiting projectile 11.40 9.91 12 93863 1354 63393793
Pneumothorax 11.40 9.91 51 93824 16210 63378937
Diabetic hyperosmolar coma 11.39 9.91 7 93868 363 63394784
Genital haemorrhage 11.38 9.91 30 93845 7302 63387845
Citrobacter test positive 11.37 9.91 3 93872 14 63395133
Joint range of motion decreased 11.37 9.91 19 93856 32409 63362738
Thrombocytosis 11.36 9.91 26 93849 5792 63389355
Clostridial infection 11.34 9.91 22 93853 4370 63390777
Myelodysplastic syndrome 11.34 9.91 52 93823 16702 63378445
Rheumatic disorder 11.33 9.91 18 93857 3054 63392093
Hypercholesterolaemia 11.26 9.91 9 93866 21325 63373822
Mucosal toxicity 11.24 9.91 7 93868 372 63394775
Transferrin decreased 11.18 9.91 6 93869 240 63394907
Gastrointestinal necrosis 11.16 9.91 17 93858 2781 63392366
Coma 11.15 9.91 53 93822 64311 63330836
Multiple-drug resistance 11.10 9.91 24 93851 5146 63390001
Impaired work ability 11.08 9.91 6 93869 17469 63377678
Product deposit 11.05 9.91 6 93869 246 63394901
Vaginal mucosal blistering 11.04 9.91 3 93872 16 63395131
Central nervous system leukaemia 11.03 9.91 5 93870 138 63395009
Enterobacter test positive 11.02 9.91 6 93869 247 63394900
SJS-TEN overlap 11.00 9.91 7 93868 386 63394761
Oliguria 10.97 9.91 34 93841 9067 63386080
Encephalitis cytomegalovirus 10.96 9.91 8 93867 553 63394594
Acute lymphocytic leukaemia recurrent 10.82 9.91 15 93860 2254 63392893
Cardiomyopathy acute 10.81 9.91 6 93869 257 63394890
Enterocolitis bacterial 10.79 9.91 6 93869 258 63394889
Adenovirus reactivation 10.77 9.91 5 93870 146 63395001
Perihepatic abscess 10.74 9.91 3 93872 18 63395129
Flushing 10.71 9.91 66 93809 75021 63320126
Cytomegalovirus oesophagitis 10.70 9.91 6 93869 262 63394885
Stress 10.68 9.91 57 93818 67110 63328037
Underdose 10.67 9.91 15 93860 27441 63367706
Palatal oedema 10.66 9.91 8 93867 577 63394570
Pathological fracture 10.65 9.91 33 93842 8801 63386346
Lymphadenopathy 10.63 9.91 95 93780 38363 63356784
Gingival blister 10.61 9.91 4 93871 68 63395079
Opsoclonus myoclonus 10.58 9.91 5 93870 152 63394995
Idiopathic intracranial hypertension 10.57 9.91 17 93858 2914 63392233
Muscle spasticity 10.53 9.91 10 93865 21784 63373363
Splenic infarction 10.52 9.91 13 93862 1746 63393401
Anal candidiasis 10.35 9.91 3 93872 21 63395126
Obstructive airways disorder 10.34 9.91 59 93816 20640 63374507
Disease progression 10.32 9.91 246 93629 122512 63272635
Mastitis fungal 10.30 9.91 4 93871 74 63395073
Nasal congestion 10.28 9.91 56 93819 65604 63329543
Lip dry 10.27 9.91 5 93870 15465 63379682
Thrombophlebitis septic 10.26 9.91 5 93870 163 63394984
Allergy test positive 10.25 9.91 8 93867 612 63394535
Injection site urticaria 10.21 9.91 4 93871 14069 63381078
Blister 10.17 9.91 133 93742 129681 63265466
Apraxia 10.16 9.91 13 93862 1808 63393339
Vulvovaginal erythema 10.11 9.91 6 93869 292 63394855
Lupus-like syndrome 10.07 9.91 5 93870 15290 63379857
Lichenification 10.06 9.91 7 93868 449 63394698
Rash macular 10.01 9.91 64 93811 23300 63371847
Malnutrition 10.00 9.91 47 93828 15251 63379896
Blood chloride decreased 9.99 9.91 24 93851 5518 63389629
Herpes virus infection 9.95 9.91 24 93851 5532 63389615
Liver function test increased 9.93 9.91 21 93854 32790 63362357
Clostridium difficile infection 9.92 9.91 77 93798 29845 63365302
Mycobacterium avium complex infection 9.92 9.91 17 93858 3071 63392076

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 493.19 10.76 962 72189 135887 34747893
Immune reconstitution inflammatory syndrome 315.82 10.76 208 72943 8551 34875229
Candida infection 285.81 10.76 261 72890 17454 34866326
Pyrexia 239.86 10.76 1346 71805 331667 34552113
Drug interaction 211.07 10.76 983 72168 224963 34658817
Pancytopenia 201.66 10.76 543 72608 94614 34789166
Mucormycosis 194.73 10.76 133 73018 5809 34877971
Cytokine release syndrome 175.96 10.76 228 72923 22649 34861131
Neutropenia 167.99 10.76 711 72440 156067 34727713
Drug abuse 158.62 10.76 13 73138 99083 34784697
Graft versus host disease 155.56 10.76 148 73003 10421 34873359
Multiple organ dysfunction syndrome 151.28 10.76 426 72725 76140 34807640
Completed suicide 148.83 10.76 16 73135 98152 34785628
Septic shock 146.18 10.76 404 72747 71430 34812350
Sepsis 145.32 10.76 711 72440 165850 34717930
Pathogen resistance 141.88 10.76 134 73017 9348 34874432
Aspergillus infection 133.69 10.76 146 73005 12108 34871672
Platelet count decreased 129.72 10.76 545 72606 119172 34764608
Toxic epidermal necrolysis 127.86 10.76 190 72961 21456 34862324
Aplastic anaemia 122.42 10.76 125 73026 9591 34874189
Neutrophil count decreased 119.77 10.76 303 72848 50801 34832979
Enterococcal infection 115.94 10.76 119 73032 9187 34874593
Mucosal inflammation 115.60 10.76 252 72899 38370 34845410
Thrombocytopenia 115.45 10.76 637 72514 155610 34728170
Systemic candida 109.46 10.76 78 73073 3648 34880132
Cytomegalovirus infection 109.01 10.76 196 72955 25939 34857841
Meningitis cryptococcal 106.38 10.76 65 73086 2339 34881441
Drug resistance 95.08 10.76 184 72967 25743 34858037
Fall 94.89 10.76 175 72976 202710 34681070
Bronchopulmonary aspergillosis 92.84 10.76 133 73018 14526 34869254
Arthralgia 90.33 10.76 135 73016 169906 34713874
Fungal infection 90.01 10.76 137 73014 15798 34867982
Disseminated intravascular coagulation 86.40 10.76 160 72991 21656 34862124
Dyspnoea 85.19 10.76 453 72698 376329 34507451
Oral candidiasis 79.83 10.76 112 73039 11998 34871782
Acute myeloid leukaemia 78.72 10.76 139 73012 18131 34865649
Hepatotoxicity 74.56 10.76 149 73002 21336 34862444
Tumour lysis syndrome 73.78 10.76 130 73021 16929 34866851
Myocardial infarction 72.51 10.76 88 73063 120997 34762783
Pseudomonas infection 72.12 10.76 108 73043 12274 34871506
White blood cell count decreased 70.96 10.76 390 72761 95055 34788725
Torsade de pointes 70.25 10.76 81 73070 7128 34876652
Blood bilirubin increased 69.68 10.76 207 72944 38089 34845691
Intentional overdose 69.10 10.76 6 73145 43668 34840112
Peripheral swelling 69.06 10.76 37 73114 76504 34807276
Joint swelling 66.89 10.76 21 73130 59869 34823911
Product dose omission issue 66.52 10.76 92 73059 119619 34764161
Fatigue 65.89 10.76 480 72671 370173 34513607
Dizziness 64.19 10.76 238 72913 218283 34665497
Pain 64.06 10.76 217 72934 204458 34679322
Cytomegalovirus viraemia 63.37 10.76 78 73073 7352 34876428
Acinetobacter infection 62.18 10.76 36 73115 1171 34882609
Respiratory failure 60.66 10.76 412 72739 108160 34775620
Cryptococcosis 60.59 10.76 46 73105 2373 34881407
Candida sepsis 60.25 10.76 36 73115 1243 34882537
Immunosuppressant drug level increased 58.95 10.76 68 73083 5987 34877793
Encephalitis 58.24 10.76 74 73077 7203 34876577
Fungaemia 58.15 10.76 46 73105 2522 34881258
Neurotoxicity 57.88 10.76 121 73030 17889 34865891
Stevens-Johnson syndrome 57.32 10.76 123 73028 18516 34865264
Acute graft versus host disease 56.65 10.76 69 73082 6434 34877346
Pneumonia 56.50 10.76 1068 72083 361559 34522221
Oesophageal candidiasis 56.18 10.76 57 73094 4339 34879441
Overdose 55.75 10.76 65 73086 90994 34792786
Electrocardiogram QT prolonged 53.60 10.76 198 72953 40754 34843026
Acute graft versus host disease in skin 53.33 10.76 60 73091 5141 34878639
Bone marrow failure 52.15 10.76 157 72994 29096 34854684
Staphylococcal infection 52.11 10.76 169 72982 32591 34851189
Bacteraemia 51.57 10.76 122 73029 19595 34864185
Rheumatoid arthritis 51.39 10.76 9 73142 38229 34845551
Alanine aminotransferase increased 50.82 10.76 316 72835 80499 34803281
Drug level increased 49.64 10.76 129 73022 21967 34861813
Inappropriate schedule of product administration 49.40 10.76 35 73116 62261 34821519
Death 49.15 10.76 565 72586 397484 34486296
Toxicity to various agents 49.04 10.76 234 72917 200128 34683652
HIV infection 48.74 10.76 32 73119 1307 34882473
Cytomegalovirus chorioretinitis 48.56 10.76 48 73103 3541 34880239
Nasopharyngitis 48.40 10.76 45 73106 69923 34813857
Intentional product misuse 47.46 10.76 18 73133 45593 34838187
Wrong technique in product usage process 47.22 10.76 9 73142 35977 34847803
Lymphocyte count decreased 46.71 10.76 128 73023 22494 34861286
Insomnia 46.41 10.76 92 73059 103815 34779965
Systemic mycosis 46.37 10.76 33 73118 1540 34882240
Clostridium difficile colitis 46.31 10.76 102 73049 15628 34868152
Prostate cancer 45.91 10.76 13 73138 39636 34844144
Plasma cell myeloma 45.12 10.76 191 72960 41846 34841934
Pain in extremity 44.58 10.76 127 73024 126386 34757394
Cardiac failure congestive 44.26 10.76 66 73085 83204 34800576
Venoocclusive liver disease 42.89 10.76 67 73084 7899 34875881
Pseudomembranous colitis 42.81 10.76 40 73111 2751 34881029
Drug reaction with eosinophilia and systemic symptoms 42.68 10.76 159 72992 32853 34850927
Gait disturbance 41.92 10.76 71 73080 85069 34798711
Anxiety 41.90 10.76 91 73060 99337 34784443
Agranulocytosis 41.66 10.76 127 73024 23694 34860086
Blood lactate dehydrogenase increased 41.55 10.76 124 73027 22866 34860914
Feeling abnormal 41.05 10.76 43 73108 63192 34820588
Aspartate aminotransferase increased 40.71 10.76 262 72889 67521 34816259
Fusarium infection 40.48 10.76 27 73124 1133 34882647
Suicidal ideation 40.28 10.76 17 73134 40371 34843409
Leukopenia 40.27 10.76 247 72904 62609 34821171
Chest pain 39.88 10.76 134 73017 126628 34757152
Cystitis haemorrhagic 39.64 10.76 54 73097 5625 34878155
Stomatitis 39.47 10.76 185 72966 42329 34841451
Human ehrlichiosis 39.32 10.76 18 73133 354 34883426
Depression 39.18 10.76 91 73060 97007 34786773
Immune effector cell-associated neurotoxicity syndrome 38.35 10.76 43 73108 3670 34880110
Haemophagocytic lymphohistiocytosis 38.05 10.76 84 73067 12889 34870891
Therapeutic product effect incomplete 38.00 10.76 30 73121 50511 34833269
Cerebrovascular accident 37.09 10.76 76 73075 84735 34799045
Drug intolerance 37.01 10.76 42 73109 59528 34824252
Acute myeloid leukaemia recurrent 37.00 10.76 33 73118 2137 34881643
Hyperhidrosis 36.46 10.76 64 73087 75628 34808152
Injection site pain 36.44 10.76 18 73133 38987 34844793
Memory impairment 36.14 10.76 23 73128 43295 34840485
Periorbital cellulitis 35.69 10.76 16 73135 299 34883481
Aplasia 35.68 10.76 46 73105 4542 34879238
Hyperbilirubinaemia 35.46 10.76 96 73055 16747 34867033
Trichosporon infection 35.46 10.76 21 73130 713 34883067
Hepatic function abnormal 35.46 10.76 185 72966 44178 34839602
Stress 35.04 10.76 10 73141 30337 34853443
Pneumonia fungal 34.51 10.76 57 73094 7043 34876737
Abdominal discomfort 34.21 10.76 45 73106 59790 34823990
Acquired immunodeficiency syndrome 33.66 10.76 18 73133 500 34883280
Fungal skin infection 33.38 10.76 34 73117 2600 34881180
Hyperferritinaemia 33.20 10.76 17 73134 431 34883349
Arthropathy 32.71 10.76 8 73143 26899 34856881
Chronic graft versus host disease 32.69 10.76 43 73108 4330 34879450
Hepatitis cholestatic 32.36 10.76 59 73092 7888 34875892
Graft versus host disease in gastrointestinal tract 31.95 10.76 39 73112 3644 34880136
Penis injury 31.56 10.76 14 73137 255 34883525
Loss of personal independence in daily activities 31.47 10.76 15 73136 33164 34850616
Phalangeal hypoplasia 31.07 10.76 10 73141 70 34883710
Klebsiella infection 30.60 10.76 60 73091 8471 34875309
Coagulopathy 30.49 10.76 101 73050 19688 34864092
Epidermolysis bullosa 30.48 10.76 11 73140 113 34883667
Hepatic failure 30.41 10.76 148 73003 34383 34849397
Encephalitis viral 30.25 10.76 23 73128 1189 34882591
Acute respiratory distress syndrome 30.23 10.76 121 73030 25848 34857932
Rhinovirus infection 30.19 10.76 41 73110 4258 34879522
Weight increased 30.17 10.76 97 73054 92936 34790844
Chest discomfort 30.17 10.76 42 73109 54488 34829292
Acute myocardial infarction 30.10 10.76 41 73110 53678 34830102
Musculoskeletal stiffness 30.00 10.76 32 73119 46648 34837132
Penile haemorrhage 29.93 10.76 18 73133 629 34883151
Blood pressure increased 29.89 10.76 90 73061 88012 34795768
Bacterial infection 29.86 10.76 91 73060 16972 34866808
Chronic obstructive pulmonary disease 29.84 10.76 35 73116 48883 34834897
Nocardiosis 29.77 10.76 39 73112 3912 34879868
Toxic neuropathy 29.67 10.76 17 73134 542 34883238
Device related infection 29.30 10.76 91 73060 17146 34866634
Cerebral toxoplasmosis 29.00 10.76 26 73125 1695 34882085
Portal fibrosis 28.70 10.76 14 73137 319 34883461
Brain abscess 28.59 10.76 34 73117 3091 34880689
Blood alkaline phosphatase increased 28.45 10.76 135 73016 31040 34852740
Intracranial pressure increased 28.20 10.76 38 73113 3917 34879863
Porphyria acute 28.15 10.76 14 73137 333 34883447
Psoriatic arthropathy 28.09 10.76 4 73147 19794 34863986
Bacterial sepsis 28.05 10.76 44 73107 5206 34878574
Liver disorder 28.04 10.76 140 73011 32857 34850923
COVID-19 27.93 10.76 77 73074 77473 34806307
Drug-induced liver injury 27.89 10.76 127 73024 28705 34855075
Stem cell transplant 27.82 10.76 28 73123 2111 34881669
Headache 27.79 10.76 277 72874 200358 34683422
Asthma 27.68 10.76 29 73122 42627 34841153
Cachexia 27.56 10.76 52 73099 7134 34876646
Coccidioidomycosis 27.12 10.76 18 73133 749 34883031
Angina pectoris 27.06 10.76 16 73135 31347 34852433
Cholestasis 27.04 10.76 120 73031 26828 34856952
Aggression 27.00 10.76 25 73126 38939 34844841
Differentiation syndrome 26.79 10.76 23 73128 1415 34882365
Clostridium test positive 26.77 10.76 34 73117 3308 34880472
Musculoskeletal pain 26.62 10.76 17 73134 31946 34851834
Aortoenteric fistula 26.39 10.76 10 73141 119 34883661
Heart rate decreased 26.28 10.76 17 73134 31728 34852052
Cough 26.27 10.76 195 72956 149945 34733835
Hypoalbuminaemia 26.24 10.76 70 73081 12104 34871676
Blood corticosterone increased 25.86 10.76 5 73146 0 34883780
Malaise 25.13 10.76 258 72893 185567 34698213
Engraftment syndrome 25.06 10.76 19 73132 978 34882802
Systemic inflammatory response syndrome 25.06 10.76 48 73103 6661 34877119
Enterococcal bacteraemia 24.98 10.76 25 73126 1872 34881908
Haemodynamic instability 24.98 10.76 59 73092 9464 34874316
CD4 lymphocytes decreased 24.89 10.76 24 73127 1717 34882063
Stiff person syndrome 24.89 10.76 9 73142 93 34883687
Long QT syndrome 24.83 10.76 30 73121 2773 34881007
Blood pressure fluctuation 24.59 10.76 11 73140 25238 34858542
Acute kidney injury 24.47 10.76 822 72329 304166 34579614
Fungal test positive 24.47 10.76 15 73136 543 34883237
Drug dependence 24.46 10.76 10 73141 24207 34859573
Toxoplasmosis 24.42 10.76 21 73130 1295 34882485
Cytomegalovirus test positive 24.22 10.76 35 73116 3851 34879929
Sedation 24.11 10.76 7 73144 20999 34862781
Cardiac disorder 24.07 10.76 33 73118 43093 34840687
Adenovirus infection 23.95 10.76 41 73110 5216 34878564
Wound dehiscence 23.90 10.76 32 73119 3279 34880501
Infection 23.85 10.76 293 72858 90622 34793158
Aspartate aminotransferase 23.84 10.76 9 73142 106 34883674
Enterococcal sepsis 23.81 10.76 23 73128 1649 34882131
Oropharyngeal candidiasis 23.57 10.76 17 73134 810 34882970
Hypertension 23.49 10.76 178 72973 136265 34747515
Osteoarthritis 23.47 10.76 7 73144 20635 34863145
Wound infection fungal 23.41 10.76 7 73144 37 34883743
Therapeutic product effect decreased 23.25 10.76 23 73128 34720 34849060
Hospitalisation 23.20 10.76 53 73098 56849 34826931
Trichoglossia 23.02 10.76 12 73139 316 34883464
Heart rate irregular 22.88 10.76 3 73148 15804 34867976
Syncope 22.80 10.76 106 73045 91345 34792435
Blood culture positive 22.71 10.76 38 73113 4745 34879035
Encephalitis fungal 22.60 10.76 10 73141 181 34883599
Kaposi's sarcoma 22.58 10.76 17 73134 866 34882914
Graft versus host disease in skin 22.52 10.76 34 73117 3891 34879889
Neuroleptic malignant syndrome 22.46 10.76 5 73146 17929 34865851
Pulmonary mucormycosis 22.10 10.76 16 73135 767 34883013
Pulmonary haemorrhage 21.96 10.76 59 73092 10245 34873535
Gallstone ileus 21.83 10.76 6 7314