fluconazole ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
systemic antifungal agents, miconazole derivatives 1187 86386-73-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • fluconazole
  • difluconazole
  • flunazol
  • diflucan
Triazole antifungal agent that is used to treat oropharyngeal CANDIDIASIS and cryptococcal MENINGITIS in AIDS.
  • Molecular weight: 306.28
  • Formula: C13H12F2N6O
  • CLOGP: 0.10
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 1
  • TPSA: 81.65
  • ALOGS: -2.34
  • ROTB: 5

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.20 g O
0.20 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 1 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 75 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 9.33 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 90 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.75 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.31 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.89 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 30 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Jan. 29, 1990 FDA PFIZER

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 566.68 9.95 735 79496 96932 50427961
Drug interaction 341.50 9.95 883 79348 198738 50326155
Candida infection 320.11 9.95 279 79952 23244 50501649
Mucosal inflammation 224.50 9.95 297 79934 39845 50485048
Contraindicated product administered 191.75 9.95 11 80220 148947 50375946
Sepsis 187.14 9.95 548 79683 132377 50392516
Multiple organ dysfunction syndrome 181.36 9.95 303 79928 50034 50474859
Fungal infection 172.63 9.95 225 80006 29740 50495153
Joint swelling 164.82 9.95 92 80139 245194 50279699
Rheumatoid arthritis 162.60 9.95 59 80172 202491 50322402
Stevens-Johnson syndrome 158.71 9.95 184 80047 21568 50503325
Cytokine release syndrome 158.63 9.95 122 80109 8512 50516381
Pemphigus 157.36 9.95 8 80223 120158 50404735
Thrombocytopenia 155.11 9.95 500 79731 127173 50397720
Pancytopenia 155.06 9.95 383 79848 83647 50441246
Septic shock 149.96 9.95 300 79931 56875 50468018
Neutropenia 144.55 9.95 539 79692 147426 50377467
Systemic lupus erythematosus 137.09 9.95 28 80203 140594 50384299
Hand deformity 136.71 9.95 5 80226 100194 50424699
Drug intolerance 133.55 9.95 92 80139 219012 50305881
Glossodynia 133.40 9.95 14 80217 115555 50409338
Arthralgia 131.93 9.95 315 79916 438387 50086506
Arthropathy 124.99 9.95 47 80184 157859 50367034
Cytomegalovirus infection 121.20 9.95 146 80085 17816 50507077
Pyrexia 117.75 9.95 1015 79216 379188 50145705
Oral candidiasis 114.97 9.95 138 80093 16777 50508116
Therapeutic product effect decreased 113.67 9.95 37 80194 136013 50388880
Graft versus host disease 113.00 9.95 87 80144 6079 50518814
Mucormycosis 107.40 9.95 60 80171 2423 50522470
Abdominal discomfort 105.76 9.95 127 80104 231514 50293379
Platelet count decreased 104.25 9.95 374 79857 100352 50424541
Infusion related reaction 100.90 9.95 73 80158 169484 50355409
Aspergillus infection 99.04 9.95 84 80147 6737 50518156
Toxic epidermal necrolysis 97.37 9.95 142 80089 20850 50504043
Abortion spontaneous 96.40 9.95 208 80023 41564 50483329
Drug ineffective 96.36 9.95 835 79396 818498 49706395
Maternal exposure during pregnancy 94.79 9.95 69 80162 159709 50365184
Pathogen resistance 90.79 9.95 74 80157 5615 50519278
Deep vein thrombosis 87.05 9.95 285 79946 73019 50451874
Systemic candida 85.55 9.95 54 80177 2736 50522157
Alopecia 82.52 9.95 165 80066 244882 50280011
Neutrophil count decreased 81.91 9.95 207 80024 45819 50479074
Bronchopulmonary aspergillosis 81.70 9.95 79 80152 7513 50517380
Wound 81.19 9.95 33 80198 105761 50419132
Fall 79.50 9.95 269 79962 334663 50190230
Immune reconstitution inflammatory syndrome 78.19 9.95 67 80164 5449 50519444
Sinusitis fungal 77.57 9.95 39 80192 1267 50523626
Fixed eruption 77.53 9.95 34 80197 805 50524088
Treatment failure 74.64 9.95 65 80166 137572 50387321
Female genital tract fistula 72.19 9.95 54 80177 3612 50521281
Discomfort 70.76 9.95 42 80189 108338 50416555
Swelling 70.43 9.95 132 80099 200740 50324153
Therapeutic product effect incomplete 69.48 9.95 29 80202 91486 50433407
Drug resistance 69.28 9.95 115 80116 18874 50506019
Hypersensitivity 68.11 9.95 150 80081 215011 50309882
Mouth ulceration 67.48 9.95 142 80089 27882 50497011
Nasopharyngitis 67.44 9.95 127 80104 192800 50332093
Salpingo-oophorectomy unilateral 66.99 9.95 27 80204 514 50524379
Peripheral swelling 65.65 9.95 143 80088 205793 50319100
Fungaemia 64.35 9.95 40 80191 1972 50522921
Fatigue 64.00 9.95 767 79464 706834 49818059
Enterococcal infection 61.80 9.95 65 80166 6833 50518060
Laryngitis fungal 60.48 9.95 18 80213 129 50524764
Cytomegalovirus viraemia 60.33 9.95 54 80177 4655 50520238
Infective aneurysm 60.29 9.95 23 80208 376 50524517
Disseminated mucormycosis 60.00 9.95 18 80213 133 50524760
Acute myeloid leukaemia 57.29 9.95 93 80138 14981 50509912
Sputum increased 56.91 9.95 36 80195 1831 50523062
Pericarditis 56.49 9.95 27 80204 78662 50446231
Torsade de pointes 56.25 9.95 81 80150 11754 50513139
Oesophageal candidiasis 55.69 9.95 53 80178 4941 50519952
Hepatic enzyme increased 54.85 9.95 83 80148 137297 50387596
Skin candida 54.53 9.95 31 80200 1295 50523598
Acute graft versus host disease in skin 54.03 9.95 42 80189 2976 50521917
Intentional overdose 53.96 9.95 16 80215 62488 50462405
Plasma cell myeloma 53.78 9.95 139 80092 31183 50493710
Bacterial sepsis 53.51 9.95 45 80186 3567 50521326
Blood lactate dehydrogenase increased 52.88 9.95 104 80127 19458 50505435
Pulmonary embolism 52.06 9.95 307 79924 101397 50423496
Neutropenic sepsis 52.04 9.95 86 80145 14061 50510832
Musculoskeletal stiffness 51.89 9.95 77 80154 128404 50396489
Respiratory symptom 50.78 9.95 37 80194 2377 50522516
Respiratory failure 50.45 9.95 281 79950 90900 50433993
Uterine perforation 49.71 9.95 56 80175 6359 50518534
Hypomagnesaemia 48.56 9.95 111 80120 23045 50501848
Pneumonia fungal 48.47 9.95 46 80185 4274 50520619
Injury 48.32 9.95 179 80052 48746 50476147
Pain 48.29 9.95 638 79593 578265 49946628
Helicobacter infection 48.19 9.95 10 80221 49692 50475201
Renal failure 47.14 9.95 310 79921 106323 50418570
Embolism venous 47.08 9.95 36 80195 2489 50522404
Bone marrow failure 46.82 9.95 122 80109 27502 50497391
Dermatitis bullous 46.26 9.95 57 80174 7116 50517777
Immune effector cell-associated neurotoxicity syndrome 44.92 9.95 26 80205 1124 50523769
Blood bilirubin increased 44.90 9.95 132 80099 31906 50492987
Fungal sepsis 44.84 9.95 26 80205 1128 50523765
Injection site pain 44.38 9.95 67 80164 110957 50413936
White blood cell count decreased 44.34 9.95 327 79904 116395 50408498
Pseudomonas infection 44.03 9.95 64 80167 9366 50515527
Acute generalised exanthematous pustulosis 43.70 9.95 62 80169 8876 50516017
Suicide attempt 43.30 9.95 14 80217 51718 50473175
Vulvovaginal candidiasis 42.92 9.95 35 80196 2657 50522236
Vaginal discharge 42.77 9.95 47 80184 5193 50519700
Hepatic function abnormal 42.36 9.95 131 80100 32550 50492343
International normalised ratio increased 41.88 9.95 157 80074 42995 50481898
Neurotoxicity 41.84 9.95 80 80151 14660 50510233
Jarisch-Herxheimer reaction 40.99 9.95 16 80215 279 50524614
Acute kidney injury 40.82 9.95 546 79685 227512 50297381
Drug reaction with eosinophilia and systemic symptoms 40.68 9.95 118 80113 28306 50496587
Product use issue 40.39 9.95 113 80118 149362 50375531
Nasal polyps 40.29 9.95 33 80198 2521 50522372
Aspartate aminotransferase increased 40.26 9.95 236 79995 77762 50447131
Cytomegalovirus test positive 39.86 9.95 33 80198 2559 50522334
Bacteraemia 39.34 9.95 77 80154 14356 50510537
Cutaneous coccidioidomycosis 39.18 9.95 9 80222 18 50524875
Cystitis haemorrhagic 38.85 9.95 38 80193 3664 50521229
Immunosuppressant drug level increased 38.80 9.95 35 80196 3047 50521846
Acute graft versus host disease 38.53 9.95 39 80192 3919 50520974
Irritable bowel syndrome 37.93 9.95 17 80214 51424 50473469
Drug level increased 37.82 9.95 90 80141 19178 50505715
Impaired healing 37.76 9.95 33 80198 69753 50455140
Anaemia 37.48 9.95 585 79646 251871 50273022
Cholecystitis chronic 37.22 9.95 60 80171 9609 50515284
Dysphagia 37.12 9.95 230 80001 77288 50447605
Geotrichum infection 36.91 9.95 17 80214 453 50524440
Hypokalaemia 36.60 9.95 252 79979 87740 50437153
Tonsillar haemorrhage 36.47 9.95 14 80217 233 50524660
Staphylococcal infection 35.74 9.95 131 80100 35485 50489408
Injection site erythema 35.30 9.95 40 80191 74896 50449997
Shock haemorrhagic 35.20 9.95 54 80177 8290 50516603
Agranulocytosis 34.67 9.95 93 80138 21328 50503565
Loss of personal independence in daily activities 34.54 9.95 36 80195 70014 50454879
Wrong technique in product usage process 34.17 9.95 23 80208 55487 50469406
Diastolic dysfunction 33.98 9.95 42 80189 5260 50519633
Breast cancer 33.51 9.95 13 80218 42877 50482016
Knee arthroplasty 33.16 9.95 8 80223 35838 50489055
Blood pressure increased 32.83 9.95 105 80126 133027 50391866
Pneumonia 31.89 9.95 805 79426 377596 50147297
Hepatic failure 31.77 9.95 118 80113 32165 50492728
Aplastic anaemia 31.30 9.95 49 80182 7654 50517239
Symmetrical drug-related intertriginous and flexural exanthema 31.30 9.95 14 80217 348 50524545
Mobility decreased 31.22 9.95 49 80182 79899 50444994
Enterobacter infection 31.06 9.95 25 80206 1863 50523030
BK virus infection 31.04 9.95 30 80201 2851 50522042
Toxic neuropathy 30.57 9.95 14 80217 368 50524525
Congenital absence of cranial vault 30.47 9.95 7 80224 14 50524879
Drug abuse 30.37 9.95 30 80201 59816 50465077
Rash maculo-papular 30.19 9.95 102 80129 26539 50498354
Clostridium difficile colitis 29.70 9.95 78 80153 17664 50507229
Psoriatic arthropathy 29.61 9.95 19 80212 47013 50477880
Blood alkaline phosphatase increased 29.59 9.95 128 80103 37398 50487495
Disseminated intravascular coagulation 29.37 9.95 76 80155 17059 50507834
Erythema multiforme 29.31 9.95 52 80179 8998 50515895
Oral disorder 29.27 9.95 48 80183 7796 50517097
Eosinophilia 29.21 9.95 80 80151 18572 50506321
Epstein-Barr virus infection 29.12 9.95 45 80186 6952 50517941
Engraftment syndrome 29.07 9.95 13 80218 323 50524570
Inappropriate schedule of product administration 29.03 9.95 43 80188 71788 50453105
Folliculitis 28.86 9.95 13 80218 39212 50485681
Contusion 28.70 9.95 87 80144 112096 50412797
Vaginal infection 28.65 9.95 42 80189 6194 50518699
Cholestasis 28.56 9.95 97 80134 25304 50499589
Acute myeloid leukaemia recurrent 28.55 9.95 21 80210 1369 50523524
Gastrointestinal fungal infection 28.52 9.95 12 80219 256 50524637
Alanine aminotransferase increased 28.29 9.95 238 79993 88121 50436772
Toxoplasmosis 28.19 9.95 21 80210 1396 50523497
Colitis 27.80 9.95 128 80103 38401 50486492
Neuropathy peripheral 27.55 9.95 254 79977 96503 50428390
Injection site swelling 27.52 9.95 16 80215 41757 50483136
Chronic graft versus host disease 27.46 9.95 28 80203 2839 50522054
Condition aggravated 27.44 9.95 320 79911 296738 50228155
Meningitis cryptococcal 27.43 9.95 19 80212 1126 50523767
Abscess neck 27.18 9.95 15 80216 591 50524302
Toxicity to various agents 26.80 9.95 212 80019 212287 50312606
Red blood cell sedimentation rate increased 26.37 9.95 7 80224 29409 50495484
Headache 26.13 9.95 608 79623 505927 50018966
Hyperbilirubinaemia 26.01 9.95 51 80180 9519 50515374
Tumour lysis syndrome 25.81 9.95 44 80187 7377 50517516
Puerperal pyrexia 25.65 9.95 7 80224 35 50524858
Sepsis syndrome 25.59 9.95 16 80215 797 50524096
Drug eruption 25.54 9.95 89 80142 23517 50501376
Electrocardiogram QT prolonged 25.49 9.95 155 80076 51731 50473162
Klebsiella infection 25.48 9.95 43 80188 7151 50517742
Arthritis 25.36 9.95 63 80168 86658 50438235
Adrenal insufficiency 25.27 9.95 64 80167 14179 50510714
Pain in extremity 25.17 9.95 294 79937 272571 50252322
Encephalopathy 25.07 9.95 113 80118 33598 50491295
Overdose 25.04 9.95 78 80153 99649 50425244
Leukopenia 24.95 9.95 188 80043 67340 50457553
Staphylococcal sepsis 24.84 9.95 42 80189 6994 50517899
Haemophagocytic lymphohistiocytosis 24.68 9.95 47 80184 8586 50516307
Liver abscess 24.24 9.95 25 80206 2568 50522325
Basal cell carcinoma 24.13 9.95 4 80227 23352 50501541
Device related infection 24.04 9.95 80 80151 20655 50504238
Respiratory tract infection fungal 23.86 9.95 12 80219 390 50524503
Failure to thrive 23.85 9.95 39 80192 6319 50518574
Accidental exposure to product 23.71 9.95 4 80227 23053 50501840
Candida sepsis 23.48 9.95 18 80213 1249 50523644
Sinus polyp 23.42 9.95 11 80220 307 50524586
Enterococcal sepsis 23.38 9.95 18 80213 1257 50523636
Oral fungal infection 23.23 9.95 24 80207 2471 50522422
Stem cell transplant 23.11 9.95 20 80211 1648 50523245
Focal myositis 23.07 9.95 6 80225 24 50524869
Septic embolus 23.07 9.95 15 80216 800 50524093
Ill-defined disorder 22.79 9.95 32 80199 54622 50470271
Pleural effusion 22.77 9.95 213 80018 81241 50443652
Blood pressure systolic increased 22.76 9.95 14 80217 35435 50489458
Dizziness 22.53 9.95 400 79831 345969 50178924
Encephalitis fungal 22.51 9.95 6 80225 27 50524866
Fungal oesophagitis 22.31 9.95 13 80218 569 50524324
Tricuspid valve incompetence 22.26 9.95 57 80174 12713 50512180
Chronic sinusitis 22.12 9.95 37 80194 6108 50518785
Hypertension 22.10 9.95 221 80010 210982 50313911
Product dose omission issue 21.99 9.95 186 80045 183652 50341241
Acute lymphocytic leukaemia 21.67 9.95 22 80209 2219 50522674
Weight increased 21.65 9.95 210 80021 201681 50323212
HIV infection 21.46 9.95 10 80221 274 50524619
Acute graft versus host disease in intestine 21.40 9.95 19 80212 1620 50523273
Diabetic macroangiopathy 21.36 9.95 8 80223 124 50524769
Disseminated cryptococcosis 21.28 9.95 11 80220 379 50524514
Delayed graft function 21.27 9.95 15 80216 915 50523978
Systemic mycosis 21.25 9.95 16 80215 1081 50523812
Staphylococcal bacteraemia 21.19 9.95 32 80199 4845 50520048
Blast cell count increased 21.13 9.95 11 80220 385 50524508
Prothrombin time shortened 21.12 9.95 19 80212 1648 50523245
Disease recurrence 21.11 9.95 75 80156 20006 50504887
Oral pain 20.99 9.95 87 80144 24946 50499947
Cystic fibrosis related diabetes 20.93 9.95 6 80225 37 50524856
Congestive cardiomyopathy 20.91 9.95 34 80197 5484 50519409
Philadelphia positive acute lymphocytic leukaemia 20.59 9.95 5 80226 14 50524879
Thrombotic microangiopathy 20.53 9.95 44 80187 8747 50516146
Nasal abscess 20.52 9.95 8 80223 139 50524754
Antithrombin III decreased 20.30 9.95 9 80222 219 50524674
Tongue blistering 20.28 9.95 17 80214 1341 50523552
Renal impairment 20.23 9.95 196 80035 75465 50449428
Gastrointestinal mucormycosis 20.18 9.95 9 80222 222 50524671
Tongue coated 20.10 9.95 16 80215 1173 50523720
Plasma cell leukaemia 20.10 9.95 15 80216 1000 50523893
Overgrowth fungal 19.95 9.95 7 80224 89 50524804
Candida test positive 19.91 9.95 14 80217 850 50524043
Feeling abnormal 19.88 9.95 117 80114 125375 50399518
Emotional distress 19.78 9.95 94 80137 28569 50496324
Urinary tract infection fungal 19.67 9.95 12 80219 572 50524321
Necrotising enterocolitis neonatal 19.58 9.95 8 80223 158 50524735
Oesophagitis 19.57 9.95 56 80175 13327 50511566
Acinetobacter infection 19.55 9.95 17 80214 1410 50523483
Lung infiltration 19.55 9.95 56 80175 13337 50511556
Incorrect dose administered 19.54 9.95 29 80202 48385 50476508
Blastomycosis 19.54 9.95 9 80222 240 50524653
Engraft failure 19.47 9.95 10 80221 340 50524553
Vaginal flatulence 19.43 9.95 9 80222 243 50524650
Gastritis fungal 19.40 9.95 7 80224 97 50524796
Graft versus host disease in skin 19.27 9.95 22 80209 2534 50522359
Graft versus host disease in lung 19.26 9.95 10 80221 348 50524545
Mucosal disorder 19.05 9.95 19 80212 1876 50523017
Gastrointestinal disorder 19.01 9.95 81 80150 94375 50430518
Intentional product use issue 18.72 9.95 61 80170 76857 50448036
Generalised oedema 18.69 9.95 56 80175 13675 50511218
Livedo reticularis 18.63 9.95 20 80211 2152 50522741
Therapeutic response decreased 18.39 9.95 29 80202 47202 50477691
Respiratory moniliasis 18.38 9.95 8 80223 186 50524707
Ureaplasma infection 18.37 9.95 11 80220 507 50524386
Nail infection 18.34 9.95 19 80212 1962 50522931
Cytopenia 18.32 9.95 42 80189 8733 50516160
Malaise 18.32 9.95 399 79832 335133 50189760
Long QT syndrome 18.21 9.95 23 80208 2944 50521949
Inhibitory drug interaction 18.17 9.95 20 80211 2213 50522680
Anhedonia 18.16 9.95 44 80187 9480 50515413
Blood pressure fluctuation 18.12 9.95 18 80213 35805 50489088
Herpes simplex 18.07 9.95 37 80194 7125 50517768
Odynophagia 17.98 9.95 35 80196 6497 50518396
Coagulation factor V level decreased 17.94 9.95 9 80222 291 50524602
Adverse event 17.88 9.95 26 80205 43737 50481156
Cerebral toxoplasmosis 17.70 9.95 12 80219 687 50524206
Coccidioidomycosis 17.65 9.95 13 80218 849 50524044
Hepatitis acute 17.62 9.95 39 80192 7922 50516971
Gamma-glutamyltransferase increased 17.52 9.95 93 80138 29530 50495363
Cryptococcosis 17.31 9.95 13 80218 875 50524018
Stenotrophomonas infection 17.27 9.95 17 80214 1652 50523241
Fungal endocarditis 17.21 9.95 8 80223 218 50524675
Venoocclusive liver disease 17.17 9.95 27 80204 4234 50520659
Fibromyalgia 17.15 9.95 28 80203 44950 50479943
Growth failure 17.13 9.95 9 80222 321 50524572
Aeromonas infection 17.12 9.95 6 80225 76 50524817
Pulmonary infarction 17.01 9.95 20 80211 2378 50522515
Proctitis 16.97 9.95 18 80213 1910 50522983
Hip arthroplasty 16.93 9.95 14 80217 30415 50494478
Pulmonary haemorrhage 16.92 9.95 34 80197 6458 50518435
Transplant rejection 16.86 9.95 43 80188 9566 50515327
Hepatic artery aneurysm 16.80 9.95 4 80227 10 50524883
Pharyngeal stenosis 16.80 9.95 4 80227 10 50524883
Poor peripheral circulation 16.80 9.95 23 80208 3185 50521708
Shock 16.71 9.95 71 80160 20579 50504314
Status epilepticus 16.69 9.95 53 80178 13353 50511540
Renal tubular acidosis 16.58 9.95 16 80215 1518 50523375
Acid base balance abnormal 16.53 9.95 8 80223 239 50524654
Sleep disorder 16.44 9.95 42 80189 57241 50467652
Toxic skin eruption 16.38 9.95 47 80184 11204 50513689
Septic pulmonary embolism 16.32 9.95 5 80226 40 50524853
Oral mucosal blistering 16.04 9.95 28 80203 4784 50520109
Stoma site candida 16.03 9.95 4 80227 13 50524880
Posterior reversible encephalopathy syndrome 15.90 9.95 56 80175 14872 50510021
Arteritis infective 15.90 9.95 5 80226 44 50524849
Injection site bruising 15.86 9.95 21 80210 36747 50488146
Pseudomonal sepsis 15.66 9.95 18 80213 2089 50522804
Purpura senile 15.62 9.95 10 80221 519 50524374
Blood culture positive 15.59 9.95 26 80205 4282 50520611
Hiatus hernia 15.57 9.95 64 80167 18280 50506613
Injection site pruritus 15.55 9.95 25 80206 40386 50484507
Capillary leak syndrome 15.51 9.95 17 80214 1873 50523020
Insomnia 15.49 9.95 190 80041 174675 50350218
Viral haemorrhagic cystitis 15.44 9.95 11 80220 682 50524211
Infective chondritis 15.38 9.95 4 80227 16 50524877
PRIDE syndrome 15.38 9.95 4 80227 16 50524877
Epstein-Barr virus associated lymphoproliferative disorder 15.28 9.95 16 80215 1673 50523220
Neural tube defect 15.25 9.95 7 80224 185 50524708
Emphysema 15.24 9.95 40 80191 9053 50515840
Intentional product misuse 15.24 9.95 32 80199 46702 50478191
Post procedural bile leak 15.15 9.95 6 80225 109 50524784
Diverticulum 15.12 9.95 44 80187 10570 50514323
Mediastinal effusion 15.07 9.95 5 80226 53 50524840
Skin exfoliation 15.01 9.95 98 80133 33514 50491379
Off label use 14.93 9.95 608 79623 473818 50051075
Respiratory syncytial virus infection 14.86 9.95 28 80203 5074 50519819
Respiratory tract haemorrhage 14.81 9.95 9 80222 426 50524467
Vulvovaginal pruritus 14.77 9.95 19 80212 2477 50522416
Rhinocerebral mucormycosis 14.75 9.95 7 80224 200 50524693
Post transplant lymphoproliferative disorder 14.72 9.95 25 80206 4179 50520714
Vulvovaginal swelling 14.71 9.95 9 80222 431 50524462
Blood creatinine increased 14.71 9.95 185 80046 75975 50448918
Vulvovaginitis 14.69 9.95 8 80223 307 50524586
Gallbladder disorder 14.68 9.95 59 80172 16683 50508210
Graft versus host disease in gastrointestinal tract 14.65 9.95 20 80211 2761 50522132
Splenic vein thrombosis 14.55 9.95 8 80223 313 50524580
Herpes simplex oesophagitis 14.43 9.95 6 80225 124 50524769
Fat necrosis 14.40 9.95 10 80221 595 50524298
Enterocolitis 14.35 9.95 32 80199 6535 50518358
Central nervous system lymphoma 14.30 9.95 14 80217 1351 50523542
Stress 14.27 9.95 41 80190 53752 50471141
Haemodialysis 14.24 9.95 37 80194 8325 50516568
Oropharyngeal candidiasis 14.21 9.95 12 80219 956 50523937
Fibrin degradation products increased 14.17 9.95 6 80225 130 50524763
Atelectasis 14.16 9.95 62 80169 18208 50506685
Exposure via breast milk 14.13 9.95 15 80216 1593 50523300
Nightmare 14.10 9.95 4 80227 16082 50508811
Cushingoid 14.09 9.95 32 80199 6613 50518280
Nervous system disorder 14.09 9.95 57 80174 16166 50508727
Acinetobacter test positive 14.08 9.95 5 80226 66 50524827
Encephalitis 13.97 9.95 34 80197 7346 50517547
Leukaemia 13.86 9.95 22 80209 3477 50521416
Angina bullosa haemorrhagica 13.84 9.95 6 80225 138 50524755
Right ventricular failure 13.84 9.95 4 80227 15889 50509004
Systemic inflammatory response syndrome 13.83 9.95 27 80204 5022 50519871
Myelosuppression 13.80 9.95 50 80181 13467 50511426
Cushing's syndrome 13.78 9.95 10 80221 638 50524255
Duodenal stenosis 13.73 9.95 9 80222 487 50524406
Neutropenic colitis 13.68 9.95 18 80213 2399 50522494
Intentional self-injury 13.66 9.95 10 80221 23102 50501791
Dysbiosis 13.62 9.95 10 80221 650 50524243
Fungal test positive 13.56 9.95 9 80222 497 50524396
Pneumothorax 13.56 9.95 51 80180 13983 50510910
Restlessness 13.49 9.95 12 80219 25161 50499732
Proteus infection 13.48 9.95 11 80220 836 50524057
Angiodermatitis 13.44 9.95 5 80226 76 50524817
Leukocytosis 13.43 9.95 71 80160 22508 50502385
Streptococcal sepsis 13.39 9.95 15 80216 1692 50523201
Petechiae 13.38 9.95 47 80184 12465 50512428
Enterococcal bacteraemia 13.37 9.95 13 80218 1245 50523648
Cachexia 13.36 9.95 25 80206 4508 50520385
Gait disturbance 13.28 9.95 163 80068 149842 50375051
Metabolic acidosis 13.18 9.95 106 80125 38719 50486174
Flushing 13.15 9.95 58 80173 66957 50457936
Chronic hepatitis C 13.13 9.95 6 80225 157 50524736
Mucosal erosion 13.11 9.95 13 80218 1274 50523619
Xanthopsia 13.09 9.95 6 80225 158 50524735
Tarsal tunnel syndrome 13.05 9.95 9 80222 530 50524363
Poikiloderma 12.92 9.95 6 80225 163 50524730
Diffuse large B-cell lymphoma 12.83 9.95 28 80203 5634 50519259
Vulvovaginal discomfort 12.81 9.95 16 80215 2025 50522868
Hyperhidrosis 12.81 9.95 86 80145 89340 50435553
Live birth 12.77 9.95 5 80226 16403 50508490
Refractory anaemia with an excess of blasts 12.75 9.95 8 80223 401 50524492
Vulvovaginal disorder 12.75 9.95 3 80228 7 50524886
Product deposit 12.72 9.95 6 80225 169 50524724
Drug ineffective for unapproved indication 12.71 9.95 67 80164 21214 50503679
Fungal skin infection 12.69 9.95 22 80209 3737 50521156
Acquired macroglossia 12.69 9.95 6 80225 170 50524723
Withdrawal syndrome 12.67 9.95 6 80225 17584 50507309
Labelled drug-drug interaction medication error 12.66 9.95 41 80190 10436 50514457
Feeling hot 12.65 9.95 27 80204 39175 50485718
Injection site reaction 12.64 9.95 39 80192 49993 50474900
Angioimmunoblastic T-cell lymphoma 12.56 9.95 5 80226 92 50524801
Myocardial infarction 12.56 9.95 86 80145 88941 50435952
Hepatotoxicity 12.53 9.95 80 80151 27146 50497747
Hysterectomy 12.51 9.95 34 80197 7856 50517037
Enterocolitis bacterial 12.34 9.95 6 80225 181 50524712
Rash erythematous 12.29 9.95 96 80135 34756 50490137
Acute sinusitis 12.24 9.95 21 80210 3539 50521354
Dermatitis diaper 12.22 9.95 6 80225 185 50524708
Gallbladder fibrosis 12.20 9.95 3 80228 9 50524884
Palatal oedema 12.05 9.95 8 80223 442 50524451
Cardiomyopathy acute 11.93 9.95 6 80225 195 50524698
Skin maceration 11.92 9.95 4 80227 44 50524849
Hypoglossal nerve paresis 11.87 9.95 5 80226 107 50524786
Mucosal toxicity 11.84 9.95 7 80224 315 50524578
Vomiting projectile 11.80 9.95 12 80219 1212 50523681
Varicella zoster virus infection 11.78 9.95 17 80214 2472 50522421
Liver disorder 11.77 9.95 100 80131 37122 50487771
Jaundice 11.76 9.95 77 80154 26352 50498541
Fracture 11.74 9.95 6 80225 16827 50508066
Extremity necrosis 11.67 9.95 13 80218 1458 50523435
Cytomegalovirus oesophagitis 11.66 9.95 6 80225 205 50524688
Acute respiratory distress syndrome 11.64 9.95 65 80166 21034 50503859
Staphylococcus test positive 11.59 9.95 20 80211 3386 50521507
Renal abscess 11.56 9.95 9 80222 639 50524254
CSF culture positive 11.54 9.95 3 80228 12 50524881
Anal candidiasis 11.54 9.95 3 80228 12 50524881
Ileus paralytic 11.52 9.95 22 80209 4028 50520865
Out of specification test results 11.50 9.95 5 80226 116 50524777
Central nervous system leukaemia 11.50 9.95 5 80226 116 50524777
Biliary dyskinesia 11.46 9.95 17 80214 2533 50522360
SJS-TEN overlap 11.39 9.95 6 80225 215 50524678
Subdiaphragmatic abscess 11.39 9.95 4 80227 51 50524842
Hypoalbuminaemia 11.39 9.95 38 80193 9822 50515071
Hallucination, tactile 11.32 9.95 6 80225 218 50524675
Haemorrhage 11.27 9.95 132 80099 53309 50471584
Gastrointestinal necrosis 11.22 9.95 17 80214 2581 50522312
Opsoclonus myoclonus 11.19 9.95 5 80226 124 50524769
Malnutrition 11.18 9.95 46 80185 13143 50511750
Citrobacter test positive 11.16 9.95 3 80228 14 50524879
Pain in jaw 11.16 9.95 28 80203 38400 50486493
Rhinorrhoea 11.15 9.95 43 80188 51540 50473353
Immunosuppressant drug level decreased 11.14 9.95 10 80221 865 50524028
Idiopathic intracranial hypertension 11.05 9.95 16 80215 2333 50522560
Splenic infarction 11.05 9.95 13 80218 1547 50523346
Acute febrile neutrophilic dermatosis 11.00 9.95 17 80214 2625 50522268
Diabetic hyperosmolar coma 10.96 9.95 7 80224 362 50524531
CD4 lymphocytes decreased 10.91 9.95 12 80219 1327 50523566
Disease progression 10.90 9.95 213 80018 95653 50429240
Impaired work ability 10.88 9.95 4 80227 13636 50511257
Enterobacter test positive 10.84 9.95 6 80225 238 50524655
Vaginal mucosal blistering 10.83 9.95 3 80228 16 50524877
Foetal death 10.79 9.95 33 80198 8147 50516746
Vulvovaginal erythema 10.79 9.95 6 80225 240 50524653
Oliguria 10.70 9.95 33 80198 8183 50516710
Vulvovaginal burning sensation 10.68 9.95 13 80218 1602 50523291
Eczema 10.63 9.95 67 80164 22635 50502258
Heparin-induced thrombocytopenia 10.62 9.95 21 80210 3944 50520949
Urinary tract infection enterococcal 10.62 9.95 16 80215 2418 50522475
Lymphopenia 10.61 9.95 51 80180 15570 50509323
Balance disorder 10.55 9.95 67 80164 70523 50454370
Perihepatic abscess 10.54 9.95 3 80228 18 50524875
Thrombocytosis 10.53 9.95 24 80207 4972 50519921
Clostridial infection 10.53 9.95 21 80210 3969 50520924
Thrombophlebitis 10.51 9.95 21 80210 3972 50520921
Cholelithiasis 10.45 9.95 99 80132 37874 50487019
Coagulation time prolonged 10.45 9.95 11 80220 1157 50523736
Road traffic accident 10.41 9.95 14 80217 24338 50500555
Herpes simplex viraemia 10.40 9.95 5 80226 147 50524746
Heart rate decreased 10.29 9.95 27 80204 36470 50488423
Marrow hyperplasia 10.26 9.95 8 80223 569 50524324
Mastitis fungal 10.18 9.95 4 80227 71 50524822
Dehydration 10.17 9.95 315 79916 152134 50372759
Blood cholesterol increased 10.12 9.95 49 80182 55166 50469727
Genital haemorrhage 10.10 9.95 28 80203 6546 50518347
Low cardiac output syndrome 10.09 9.95 6 80225 273 50524620
Lichenification 10.07 9.95 7 80224 417 50524476
Lymphadenopathy 10.07 9.95 89 80142 33410 50491483
Herpes dermatitis 10.02 9.95 3 80228 22 50524871
Pneumonia influenzal 10.02 9.95 12 80219 1455 50523438
Aplasia 9.98 9.95 20 80211 3793 50521100
Eye disorder 9.96 9.95 9 80222 18730 50506163
Medication error 9.96 9.95 27 80204 36077 50488816
Hepatorenal failure 9.95 9.95 8 80223 595 50524298

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 451.06 10.46 861 65608 111379 29396679
Immune reconstitution inflammatory syndrome 261.58 10.46 182 66287 7620 29500438
Candida infection 258.13 10.46 238 66231 14987 29493071
Pyrexia 226.85 10.46 1255 65214 286367 29221691
Pancytopenia 195.70 10.46 516 65953 82652 29425406
Drug interaction 177.61 10.46 894 65575 196491 29311567
Mucormycosis 167.48 10.46 118 66351 5040 29503018
Cytokine release syndrome 164.52 10.46 174 66295 12945 29495113
Neutropenia 160.60 10.46 653 65816 131058 29377000
Multiple organ dysfunction syndrome 154.95 10.46 398 66071 62718 29445340
Sepsis 153.54 10.46 681 65788 142001 29366057
Drug abuse 146.87 10.46 8 66461 79875 29428183
Completed suicide 146.46 10.46 16 66453 90230 29417828
Septic shock 139.84 10.46 381 66088 62179 29445879
Graft versus host disease 139.42 10.46 138 66331 9490 29498568
Toxic epidermal necrolysis 129.61 10.46 181 66288 17972 29490086
Platelet count decreased 120.44 10.46 510 65959 104162 29403896
Aspergillus infection 119.83 10.46 133 66336 10448 29497610
Pathogen resistance 111.39 10.46 113 66356 8003 29500055
Enterococcal infection 109.63 10.46 113 66356 8155 29499903
Thrombocytopenia 105.44 10.46 588 65881 134235 29373823
Fungal infection 92.58 10.46 133 66336 13552 29494506
Fall 91.84 10.46 161 66308 177017 29331041
Cytomegalovirus infection 91.50 10.46 177 66292 23038 29485020
Neutrophil count decreased 91.04 10.46 259 66210 43308 29464750
Bronchopulmonary aspergillosis 89.48 10.46 124 66345 12220 29495838
Mucosal inflammation 88.86 10.46 210 66259 31385 29476673
Meningitis cryptococcal 87.26 10.46 56 66413 2044 29506014
Drug resistance 84.61 10.46 164 66305 21376 29486682
Systemic candida 84.27 10.46 61 66408 2719 29505339
Arthralgia 79.69 10.46 119 66350 139498 29368560
Disseminated intravascular coagulation 78.33 10.46 152 66317 19828 29488230
Dyspnoea 76.54 10.46 427 66042 326305 29181753
Myocardial infarction 75.39 10.46 82 66387 110214 29397844
Oral candidiasis 75.17 10.46 106 66363 10616 29497442
Product dose omission issue 71.17 10.46 67 66402 96316 29411742
Hepatotoxicity 67.70 10.46 134 66335 17733 29490325
Intentional overdose 64.62 10.46 6 66463 38522 29469536
Blood bilirubin increased 64.58 10.46 195 66274 33698 29474360
Aplastic anaemia 64.53 10.46 82 66387 7428 29500630
Torsade de pointes 64.10 10.46 77 66392 6584 29501474
Peripheral swelling 63.38 10.46 32 66437 63707 29444351
Immunosuppressant drug level increased 62.94 10.46 65 66404 4700 29503358
White blood cell count decreased 62.69 10.46 360 66109 83002 29425056
Dizziness 62.44 10.46 218 66251 189466 29318592
Candida sepsis 62.21 10.46 36 66433 1087 29506971
Pseudomonas infection 59.97 10.46 96 66373 10756 29497302
Acute myeloid leukaemia 59.17 10.46 121 66348 16392 29491666
Cryptococcosis 57.28 10.46 42 66427 1910 29506148
Acinetobacter infection 57.25 10.46 33 66436 989 29507069
Fatigue 56.07 10.46 450 66019 316371 29191687
Joint swelling 55.54 10.46 21 66448 49609 29458449
Overdose 52.70 10.46 61 66408 79758 29428300
Oesophageal candidiasis 52.06 10.46 53 66416 3768 29504290
Pain 51.82 10.46 204 66265 171228 29336830
Encephalitis 51.79 10.46 68 66401 6362 29501696
Acute graft versus host disease in skin 51.72 10.46 58 66411 4606 29503452
Cytomegalovirus viraemia 51.15 10.46 67 66402 6253 29501805
Pneumonia 50.60 10.46 1004 65465 319168 29188890
Stevens-Johnson syndrome 50.05 10.46 113 66356 16384 29491674
Cytomegalovirus chorioretinitis 49.84 10.46 48 66421 3190 29504868
Alanine aminotransferase increased 49.22 10.46 300 66169 70644 29437414
Respiratory failure 49.13 10.46 380 66089 96751 29411307
Cardiac failure congestive 48.98 10.46 60 66409 76521 29431537
Bone marrow failure 48.64 10.46 154 66315 27295 29480763
Death 48.37 10.46 514 65955 341570 29166488
Wrong technique in product usage process 47.48 10.46 7 66462 31421 29476637
Fungaemia 46.80 10.46 39 66430 2142 29505916
Rheumatoid arthritis 46.69 10.46 8 66461 32144 29475914
Tumour lysis syndrome 46.54 10.46 99 66370 13785 29494273
Electrocardiogram QT prolonged 45.34 10.46 181 66288 35956 29472102
Toxicity to various agents 44.98 10.46 219 66250 173442 29334616
Acute graft versus host disease 44.46 10.46 60 66409 5764 29502294
Lymphocyte count decreased 43.62 10.46 118 66351 19153 29488905
Drug level increased 43.50 10.46 116 66353 18671 29489387
Plasma cell myeloma 43.48 10.46 182 66287 36933 29471125
Nasopharyngitis 43.40 10.46 42 66427 59623 29448435
Cystitis haemorrhagic 43.40 10.46 54 66415 4788 29503270
Therapeutic product effect incomplete 43.36 10.46 17 66452 39288 29468770
Insomnia 42.94 10.46 84 66385 88677 29419381
Venoocclusive liver disease 42.13 10.46 64 66405 6853 29501205
Pain in extremity 41.85 10.46 119 66350 110314 29397744
Gait disturbance 41.33 10.46 63 66406 73286 29434772
HIV infection 40.63 10.46 28 66441 1153 29506905
Aspartate aminotransferase increased 40.43 10.46 251 66218 59474 29448584
Staphylococcal infection 40.39 10.46 151 66318 29089 29478969
Pruritus genital 40.09 10.46 21 66448 519 29507539
Systemic mycosis 40.07 10.46 29 66440 1292 29506766
Intentional product misuse 39.90 10.46 14 66455 34647 29473411
Cerebrovascular accident 39.66 10.46 70 66399 76841 29431217
Pseudomembranous colitis 39.03 10.46 38 66431 2559 29505499
Bacteraemia 39.02 10.46 102 66367 16221 29491837
Neurotoxicity 38.78 10.46 95 66374 14518 29493540
Agranulocytosis 38.71 10.46 117 66352 20223 29487835
Drug reaction with eosinophilia and systemic symptoms 38.20 10.46 144 66325 27848 29480210
Clostridium test positive 37.63 10.46 34 66435 2083 29505975
Fusarium infection 37.55 10.46 25 66444 972 29507086
Injection site pain 37.53 10.46 13 66456 32433 29475625
Hyperferritinaemia 36.60 10.46 17 66452 321 29507737
Anxiety 36.14 10.46 87 66382 85278 29422780
Chest pain 35.90 10.46 130 66339 111843 29396215
Feeling abnormal 35.50 10.46 42 66427 54403 29453655
Suicidal ideation 35.15 10.46 17 66452 34699 29473359
Pneumonia fungal 34.55 10.46 53 66416 5724 29502334
Aplasia 34.33 10.46 44 66425 4019 29504039
Blood lactate dehydrogenase increased 34.23 10.46 108 66361 19101 29488957
Acute myocardial infarction 34.19 10.46 35 66434 48403 29459655
Trichosporon infection 34.09 10.46 20 66449 620 29507438
Fungal skin infection 34.02 10.46 34 66435 2364 29505694
Porphyria acute 34.00 10.46 14 66455 195 29507863
Inappropriate schedule of product administration 33.88 10.46 30 66439 44442 29463616
Stomatitis 33.80 10.46 169 66300 36944 29471114
Depression 33.55 10.46 90 66379 85057 29423001
Chronic graft versus host disease 33.05 10.46 43 66426 3986 29504072
Toxic neuropathy 32.90 10.46 17 66452 408 29507650
Acquired immunodeficiency syndrome 32.83 10.46 17 66452 410 29507648
Leukopenia 32.49 10.46 224 66245 54979 29453079
Acute myeloid leukaemia recurrent 32.45 10.46 29 66440 1751 29506307
Hyperbilirubinaemia 32.36 10.46 90 66379 14844 29493214
Clostridium difficile colitis 32.03 10.46 83 66386 13129 29494929
Graft versus host disease in gastrointestinal tract 31.90 10.46 38 66431 3220 29504838
Liver disorder 31.66 10.46 135 66334 27614 29480444
Hyperhidrosis 31.27 10.46 61 66408 64479 29443579
Penis injury 31.11 10.46 14 66455 245 29507813
Hepatic function abnormal 31.10 10.46 172 66297 39087 29468971
Memory impairment 31.06 10.46 22 66447 36448 29471610
Hypoalbuminaemia 30.60 10.46 70 66399 10235 29497823
Epidermolysis bullosa 30.33 10.46 11 66458 106 29507952
Encephalitis viral 30.19 10.46 23 66446 1109 29506949
Immune effector cell-associated neurotoxicity syndrome 30.13 10.46 26 66443 1498 29506560
Penile haemorrhage 29.89 10.46 18 66451 586 29507472
Acute respiratory distress syndrome 29.67 10.46 116 66353 22819 29485239
Bacterial infection 29.02 10.46 79 66390 12869 29495189
Drug intolerance 28.77 10.46 40 66429 48339 29459719
Long QT syndrome 28.39 10.46 30 66439 2228 29505830
Differentiation syndrome 28.34 10.46 22 66447 1091 29506967
Portal fibrosis 28.24 10.46 14 66455 307 29507751
Cachexia 28.24 10.46 51 66418 6298 29501760
Stem cell transplant 27.87 10.46 28 66441 1959 29506099
Blood pressure increased 27.59 10.46 80 66389 73723 29434335
Phalangeal hypoplasia 27.21 10.46 9 66460 64 29507994
Aggression 27.04 10.46 24 66445 35517 29472541
Device related infection 27.03 10.46 87 66382 15549 29492509
Headache 26.74 10.46 256 66213 173751 29334307
Prostate cancer 26.61 10.46 12 66457 25515 29482543
Weight increased 26.60 10.46 86 66383 76581 29431477
Blood alkaline phosphatase increased 26.32 10.46 130 66339 28276 29479782
Abdominal discomfort 26.16 10.46 42 66427 47861 29460197
Arthropathy 26.05 10.46 8 66461 21546 29486512
Stress 25.93 10.46 8 66461 21482 29486576
Cerebral toxoplasmosis 25.68 10.46 23 66446 1393 29506665
Blood corticosterone increased 25.50 10.46 5 66464 0 29508058
Aspartate aminotransferase 25.36 10.46 9 66460 81 29507977
Klebsiella infection 25.32 10.46 53 66416 7296 29500762
Toxoplasmosis 25.31 10.46 21 66448 1146 29506912
Musculoskeletal pain 25.27 10.46 17 66452 28936 29479122
CD4 lymphocytes decreased 25.18 10.46 24 66445 1574 29506484
Bacterial sepsis 25.16 10.46 41 66428 4662 29503396
Malaise 24.86 10.46 234 66235 159368 29348690
Fungal test positive 24.86 10.46 15 66454 490 29507568
Angina pectoris 24.78 10.46 16 66453 27834 29480224
Enterococcal sepsis 24.51 10.46 23 66446 1479 29506579
Wound dehiscence 24.44 10.46 32 66437 2985 29505073
Foetal exposure during pregnancy 24.44 10.46 24 66445 33843 29474215
Coagulopathy 24.33 10.46 92 66377 17815 29490243
Musculoskeletal stiffness 24.30 10.46 29 66440 37429 29470629
Hepatic failure 24.25 10.46 137 66332 31375 29476683
Chronic obstructive pulmonary disease 24.21 10.46 34 66435 40921 29467137
Enterococcal bacteraemia 24.11 10.46 23 66446 1510 29506548
Adenovirus infection 24.10 10.46 39 66430 4408 29503650
Infection 23.99 10.46 271 66198 76480 29431578
C-reactive protein increased 23.94 10.46 176 66293 44087 29463971
Pulmonary mucormycosis 23.58 10.46 15 66454 539 29507519
Chest discomfort 23.56 10.46 42 66427 45941 29462117
Wound infection fungal 23.40 10.46 7 66462 34 29508024
Drug dependence 23.26 10.46 9 66460 20972 29487086
Cough 23.23 10.46 178 66291 126549 29381509
Haemodynamic instability 23.05 10.46 54 66415 8019 29500039
Cardiac disorder 22.97 10.46 30 66439 37233 29470825
Encephalitis fungal 22.27 10.46 10 66459 174 29507884
Pulmonary haemorrhage 22.23 10.46 58 66411 9212 29498846
Asthma 22.18 10.46 26 66443 33823 29474235
Drug-induced liver injury 22.16 10.46 102 66367 21553 29486505
Loss of personal independence in daily activities 22.12 10.46 15 66454 25425 29482633
Blood culture positive 21.95 10.46 38 66431 4539 29503519
Kaposi's sarcoma 21.86 10.46 17 66452 845 29507213
Staphylococcal sepsis 21.82 10.46 56 66413 8806 29499252
Hospitalisation 21.81 10.46 44 66425 45944 29462114
Coccidioidomycosis 21.69 10.46 15 66454 621 29507437
Adrenal suppression 21.64 10.46 14 66455 518 29507540
Ocular icterus 21.59 10.46 28 66441 2587 29505471
Stiff person syndrome 21.54 10.46 8 66461 83 29507975
Gallstone ileus 21.41 10.46 6 66463 22 29508036
Osteoarthritis 21.38 10.46 7 66462 18096 29489962
Stenotrophomonas test positive 21.36 10.46 11 66458 262 29507796
Acute generalised exanthematous pustulosis 21.30 10.46 42 66427 5541 29502517
Blood pressure fluctuation 21.29 10.46 9 66460 19885 29488173
Adrenal insufficiency 21.21 10.46 64 66405 11050 29497008
Therapeutic product effect decreased 21.10 10.46 21 66448 29430 29478628
Arthritis fungal 20.96 10.46 8 66461 90 29507968
Hypokalaemia 20.86 10.46 188 66281 50015 29458043
Psoriasis 20.85 10.46 25 66444 32202 29475856
Atelectasis 20.85 10.46 79 66390 15313 29492745
Aortoenteric fistula 20.65 10.46 8 66461 94 29507964
Muscle spasms 20.55 10.46 76 66393 65006 29443052
Myalgia 20.50 10.46 91 66378 73928 29434130
Pseudomonal sepsis 20.49 10.46 29 66440 2913 29505145
Fluorosis 20.45 10.46 7 66462 56 29508002
Sleep apnoea syndrome 20.44 10.46 7 66462 17592 29490466
Anterior displaced anus 20.40 10.46 4 66465 0 29508058
Central venous pressure increased 20.37 10.46 5 66464 9 29508049
Coronary artery disease 20.35 10.46 43 66426 44147 29463911
Road traffic accident 20.25 10.46 5 66464 15556 29492502
Graft versus host disease in skin 20.20 10.46 31 66438 3348 29504710
Sedation 20.08 10.46 7 66462 17398 29490660
Dysbiosis 20.05 10.46 12 66457 386 29507672
Neutropenic sepsis 20.04 10.46 65 66404 11662 29496396
Engraftment syndrome 20.03 10.46 16 66453 827 29507231
Mycobacterium avium complex infection 19.85 10.46 25 66444 2244 29505814
Gastrooesophageal reflux disease 19.78 10.46 25 66444 31471 29476587
Syncope 19.67 10.46 105 66364 81266 29426792
Heart rate irregular 19.63 10.46 3 66466 13114 29494944
Engraft failure 19.54 10.46 12 66457 405 29507653
Skin necrosis 19.48 10.46 38 66431 4974 29503084
Cholestasis 19.39 10.46 104 66365 23358 29484700
Haematotoxicity 19.33 10.46 45 66424 6654 29501404
Gamma-glutamyltransferase increased 19.11 10.46 114 66355 26623 29481435
Heart rate decreased 18.74 10.46 17 66452 24895 29483163
Cytomegalovirus test positive 18.52 10.46 30 66439 3393 29504665
Respiratory tract infection fungal 18.52 10.46 14 66455 667 29507391
Acute kidney injury 18.51 10.46 750 65719 264517 29243541
Jaundice 18.50 10.46 121 66348 29175 29478883
Acute lymphocytic leukaemia 18.42 10.46 26 66443 2605 29505453
Hyperadrenocorticism 18.32 10.46 7 66462 79 29507979
Therapy cessation 18.15 10.46 5 66464 14457 29493601
Hypertension 18.13 10.46 171 66298 116443 29391615
Secondary adrenocortical insufficiency 18.11 10.46 17 66452 1094 29506964
Irritability 18.04 10.46 14 66455 22138 29485920
Incorrect dose administered 17.93 10.46 29 66440 32955 29475103
Hepatic cytolysis 17.78 10.46 50 66419 8297 29499761
Mobility decreased 17.77 10.46 19 66450 25761 29482297
Hepatic necrosis 17.77 10.46 30 66439 3512 29504546
Vision blurred 17.75 10.46 40 66429 40136 29467922
Elbow synostosis 17.70 10.46 5 66464 19 29508039
Blast cell count increased 17.70 10.46 16 66453 981 29507077
Odynophagia 17.65 10.46 35 66434 4635 29503423
Enterococcus test positive 17.57 10.46 14 66455 721 29507337
Oral mucosal erythema 17.55 10.46 11 66458 385 29507673
Eschar 17.39 10.46 13 66456 609 29507449
Choreoathetosis 17.38 10.46 16 66453 1004 29507054
Opportunistic infection 17.34 10.46 19 66450 1470 29506588
Blood glucose increased 17.26 10.46 71 66398 58913 29449145
Disseminated cryptococcosis 17.26 10.46 17 66452 1161 29506897
Flushing 17.20 10.46 24 66445 28968 29479090
Systemic inflammatory response syndrome 17.07 10.46 40 66429 5941 29502117
Rash maculo-papular 17 10.46 103 66366 24186 29483872
Nephropathy toxic 16.94 10.46 58 66411 10698 29497360
Haemophagocytic lymphohistiocytosis 16.86 10.46 57 66412 10447 29497611
Idiosyncratic drug reaction 16.81 10.46 11 66458 415 29507643
Bradycardia 16.81 10.46 83 66386 65546 29442512
Intracranial pressure increased 16.80 10.46 29 66440 3456 29504602
IVth nerve paralysis 16.71 10.46 7 66462 102 29507956
Synostosis 16.65 10.46 7 66462 103 29507955
Escherichia sepsis 16.65 10.46 31 66438 3918 29504140
Brachycephaly 16.44 10.46 6 66463 59 29507999
Pulmonary alveolar haemorrhage 16.42 10.46 41 66428 6339 29501719
Swelling face 16.39 10.46 13 66456 20337 29487721
Geotrichum infection 16.38 10.46 11 66458 434 29507624
Enterobacter test positive 16.11 10.46 8 66461 176 29507882
Diabetic ketoacidosis 16.07 10.46 8 66461 16065 29491993
Dermatitis 15.92 10.46 46 66423 7752 29500306
Acute hepatic failure 15.90 10.46 61 66408 11891 29496167
Back pain 15.89 10.46 150 66319 102134 29405924
Swollen tongue 15.85 10.46 4 66465 12262 29495796
Hepatic enzyme increased 15.83 10.46 130 66339 33669 29474389
Dyspnoea exertional 15.58 10.46 37 66432 36453 29471605
SARS-CoV-2 sepsis 15.53 10.46 7 66462 123 29507935
Unevaluable event 15.53 10.46 27 66442 29824 29478234
Klebsiella sepsis 15.44 10.46 19 66450 1665 29506393
Pneumonia pseudomonal 15.38 10.46 27 66442 3260 29504798
Anticonvulsant drug level abnormal 15.31 10.46 5 66464 34 29508024
Mycetoma mycotic 15.23 10.46 6 66463 74 29507984
Anger 15.18 10.46 3 66466 10887 29497171
Renal impairment 15.16 10.46 262 66207 81071 29426987
Pseudomonas test positive 15.15 10.46 14 66455 883 29507175
HIV associated nephropathy 15.05 10.46 9 66460 289 29507769
Streptococcal infection 15.04 10.46 32 66437 4456 29503602
Oedema 15.01 10.46 148 66321 40335 29467723
Familial periodic paralysis 15.01 10.46 6 66463 77 29507981
Nosocomial infection 15.01 10.46 15 66454 1043 29507015
Congenital foot malformation 14.97 10.46 10 66459 391 29507667
Neurological symptom 14.90 10.46 27 66442 3343 29504715
Meningitis coccidioides 14.88 10.46 4 66465 12 29508046
Mediastinitis 14.88 10.46 12 66457 629 29507429
Culture stool positive 14.87 10.46 8 66461 209 29507849
Generalised oedema 14.87 10.46 57 66412 11108 29496950
Hypertransaminasaemia 14.82 10.46 28 66441 3578 29504480
Respiratory distress 14.78 10.46 123 66346 31983 29476075
Mucosal infection 14.70 10.46 8 66461 214 29507844
Oropharyngeal candidiasis 14.68 10.46 12 66457 641 29507417
Prostatic specific antigen increased 14.59 10.46 5 66464 12559 29495499
Faeces pale 14.55 10.46 16 66453 1243 29506815
Hepatomegaly 14.46 10.46 50 66419 9267 29498791
Cytomegalovirus enterocolitis 14.34 10.46 13 66456 800 29507258
Contraindicated product administered 14.30 10.46 12 66457 18254 29489804
Cytomegalovirus test 14.29 10.46 5 66464 43 29508015
Sputum purulent 14.15 10.46 10 66459 429 29507629
Epstein-Barr viraemia 14.12 10.46 14 66455 964 29507094
Osteonecrosis of jaw 14 10.46 10 66459 16500 29491558
Gastrointestinal wall thinning 14.00 10.46 4 66465 16 29508042
Angioedema 13.91 10.46 32 66437 31883 29476175
Product prescribing error 13.84 10.46 12 66457 17964 29490094
Application site haematoma 13.71 10.46 5 66464 49 29508009
Cytopenia 13.68 10.46 51 66418 9808 29498250
Sleep disorder 13.67 10.46 21 66448 24365 29483693
Trichoglossia 13.65 10.46 6 66463 99 29507959
Arthritis 13.59 10.46 22 66447 24997 29483061
Stenotrophomonas infection 13.58 10.46 18 66451 1699 29506359
Hepatocellular injury 13.57 10.46 88 66381 21155 29486903
Gram stain positive 13.44 10.46 6 66463 103 29507955
Organ failure 13.36 10.46 19 66450 1917 29506141
Meningism 13.33 10.46 7 66462 174 29507884
Peritoneal candidiasis 13.28 10.46 4 66465 20 29508038
Type 2 diabetes mellitus 13.22 10.46 7 66462 13574 29494484
Pleural effusion 13.17 10.46 231 66238 71677 29436381
Drug ineffective for unapproved indication 13.13 10.46 65 66404 14149 29493909
Transplant rejection 13.07 10.46 48 66421 9164 29498894
Renal failure 13.05 10.46 354 66115 118245 29389813
Product administration error 13.04 10.46 8 66461 14302 29493756
Viraemia 13.03 10.46 14 66455 1060 29506998
Product quality issue 13.00 10.46 10 66459 15885 29492173
Balance disorder 12.94 10.46 40 66429 36130 29471928
Ventricular tachycardia 12.91 10.46 91 66378 22483 29485575
Myelodysplastic syndrome 12.80 10.46 76 66393 17718 29490340
Staphylococcal bacteraemia 12.79 10.46 40 66429 7039 29501019
Premature baby 12.75 10.46 12 66457 17268 29490790
Dysarthria 12.68 10.46 32 66437 30879 29477179
Klebsiella bacteraemia 12.68 10.46 14 66455 1093 29506965
Brain abscess 12.67 10.46 22 66447 2633 29505425
Respiratory paralysis 12.66 10.46 5 66464 62 29507996
Hepatitis fulminant 12.59 10.46 26 66443 3545 29504513
Viral test positive 12.54 10.46 7 66462 197 29507861
Mycobacterial infection 12.49 10.46 18 66451 1838 29506220
Multiple sclerosis relapse 12.49 10.46 5 66464 11414 29496644
Blood creatine phosphokinase increased 12.48 10.46 48 66421 40596 29467462
Chronic lymphocytic leukaemia 12.28 10.46 26 66443 3607 29504451
Contusion 12.14 10.46 33 66436 31062 29476996
Streptococcal bacteraemia 12.11 10.46 17 66452 1694 29506364
Venoocclusive disease 12.07 10.46 21 66448 2518 29505540
Psychotic disorder 11.92 10.46 17 66452 20337 29487721
Macule 11.90 10.46 13 66456 1003 29507055
Ischaemic hepatitis 11.89 10.46 16 66453 1532 29506526
Nasal congestion 11.84 10.46 15 66454 18864 29489194
Citrobacter infection 11.83 10.46 9 66460 433 29507625
End stage AIDS 11.79 10.46 4 66465 31 29508027
Haemodialysis 11.79 10.46 49 66420 9905 29498153
Lung neoplasm malignant 11.78 10.46 9 66460 14348 29493710
Somnolence 11.69 10.46 145 66324 93810 29414248
Prothrombin time prolonged 11.69 10.46 45 66424 8787 29499271
Paraesthesia 11.65 10.46 72 66397 53773 29454285
Liver transplant rejection 11.65 10.46 18 66451 1956 29506102
Rhinorrhoea 11.62 10.46 19 66450 21500 29486558
Hepatitis cholestatic 11.59 10.46 38 66431 6855 29501203
Monocytopenia 11.52 10.46 5 66464 80 29507978
Periorbital cellulitis 11.51 10.46 7 66462 232 29507826
Angina unstable 11.49 10.46 5 66464 10860 29497198
Cholangitis infective 11.46 10.46 7 66462 234 29507824
Chronic hepatitis C 11.45 10.46 8 66461 337 29507721
Therapeutic response decreased 11.41 10.46 24 66445 24687 29483371
COVID-19 11.40 10.46 42 66427 35972 29472086
Metastases to bone 11.39 10.46 4 66465 9894 29498164
Dermatitis exfoliative 11.33 10.46 36 66433 6389 29501669
Obesity 11.32 10.46 4 66465 9859 29498199
Accidental exposure to product 11.29 10.46 5 66464 10748 29497310
T-cell lymphoma recurrent 11.27 10.46 4 66465 36 29508022
Central nervous system lesion 11.23 10.46 33 66436 5615 29502443
Hyperleukocytosis 11.21 10.46 16 66453 1619 29506439
Graft versus host disease in liver 11.19 10.46 13 66456 1073 29506985
Superinfection fungal 11.16 10.46 3 66466 9 29508049
Pleocytosis 11.16 10.46 9 66460 472 29507586
Gastroduodenal ulcer 11.14 10.46 8 66461 352 29507706
Dystonia 11.11 10.46 4 66465 9745 29498313
HIV wasting syndrome 11.08 10.46 5 66464 88 29507970
Basal cell carcinoma 11.06 10.46 13 66456 16897 29491161
Accidental overdose 11.01 10.46 14 66455 17579 29490479
Urinary tract candidiasis 11.01 10.46 6 66463 161 29507897
Hypophosphataemia 11.00 10.46 41 66428 7883 29500175
Laryngitis fungal 10.90 10.46 4 66465 40 29508018
Eyelid ptosis congenital 10.88 10.46 5 66464 92 29507966
Candida test positive 10.81 10.46 8 66461 369 29507689
Hypersensitivity 10.80 10.46 72 66397 52831 29455227
Cardio-respiratory arrest 10.77 10.46 68 66401 50533 29457525
Hyperthyroidism 10.76 10.46 3 66466 8605 29499453
Herpes zoster reactivation 10.73 10.46 7 66462 263 29507795
Hyperuricaemia 10.72 10.46 37 66432 6852 29501206
Gastroenteritis cryptosporidial 10.71 10.46 6 66463 170 29507888
Polyomavirus viraemia 10.71 10.46 10 66459 639 29507419
Diffuse alopecia 10.70 10.46 3 66466 11 29508047
Heart rate increased 10.70 10.46 48 66421 38890 29469168
Anaemia 10.69 10.46 553 65916 200398 29307660
Epstein-Barr virus infection 10.66 10.46 36 66433 6593 29501465
Acute graft versus host disease in intestine 10.66 10.46 19 66450 2322 29505736
Oesophagitis 10.64 10.46 54 66415 11869 29496189
Pseudomonal bacteraemia 10.63 10.46 12 66457 960 29507098
Delusion 10.60 10.46 6 66463 11210 29496848
Spinal cord injury thoracic 10.60 10.46 5 66464 98 29507960
Erectile dysfunction 10.59 10.46 15 66454 17994 29490064
Nephrolithiasis 10.57 10.46 26 66443 25308 29482750
Device malfunction 10.57 10.46 3 66466 8504 29499554
Drug withdrawal syndrome 10.56 10.46 15 66454 17969 29490089
Injection site swelling 10.50 10.46 4 66465 9413 29498645

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 831.47 9.68 1372 121916 186285 64189159
Candida infection 533.16 9.68 458 122830 30961 64344483
Drug interaction 452.47 9.68 1619 121669 360464 64014980
Completed suicide 354.57 9.68 18 123270 224396 64151048
Pancytopenia 332.44 9.68 800 122488 142509 64232935
Immune reconstitution inflammatory syndrome 319.94 9.68 232 123056 12238 64363206
Multiple organ dysfunction syndrome 298.93 9.68 623 122665 100790 64274654
Cytokine release syndrome 290.70 9.68 272 123016 20557 64354887
Pyrexia 288.64 9.68 1939 121349 556705 63818739
Sepsis 282.82 9.68 1025 122263 229316 64146128
Mucosal inflammation 279.65 9.68 460 122828 62124 64313320
Mucormycosis 260.73 9.68 167 123121 7174 64368270
Neutropenia 254.34 9.68 1018 122270 238606 64136838
Septic shock 252.39 9.68 596 122692 104841 64270603
Thrombocytopenia 229.66 9.68 941 122347 222860 64152584
Pathogen resistance 219.14 9.68 186 123102 12357 64363087
Graft versus host disease 215.44 9.68 192 123096 13621 64361823
Arthralgia 213.69 9.68 322 122966 441938 63933506
Fungal infection 213.27 9.68 294 122994 33957 64341487
Platelet count decreased 202.85 9.68 743 122545 166968 64208476
Joint swelling 202.73 9.68 79 123209 215303 64160141
Rheumatoid arthritis 185.85 9.68 43 123245 164251 64211193
Cytomegalovirus infection 183.36 9.68 286 123002 36913 64338531
Aspergillus infection 180.41 9.68 188 123100 16191 64359253
Toxic epidermal necrolysis 179.38 9.68 283 123005 36883 64338561
Synovitis 174.11 9.68 3 123285 99087 64276357
Fall 166.36 9.68 342 122946 416484 63958960
Stevens-Johnson syndrome 165.58 9.68 261 123027 33988 64341456
Enterococcal infection 159.66 9.68 163 123125 13703 64361741
Systemic candida 159.59 9.68 109 123179 5220 64370224
Drug abuse 159.26 9.68 30 123258 132344 64243100
Bronchopulmonary aspergillosis 155.19 9.68 187 123101 18898 64356546
Neutrophil count decreased 140.76 9.68 394 122894 76802 64298642
Drug intolerance 132.99 9.68 99 123189 187893 64187551
Contraindicated product administered 132.81 9.68 23 123265 107806 64267638
Oral candidiasis 132.26 9.68 191 123097 23021 64352423
Arthropathy 132.21 9.68 34 123254 120933 64254511
Drug resistance 124.27 9.68 233 123055 34869 64340575
Peripheral swelling 120.70 9.68 133 123155 209020 64166424
Meningitis cryptococcal 110.70 9.68 70 123218 2939 64372505
Therapeutic product effect decreased 110.65 9.68 41 123247 115310 64260134
Nasopharyngitis 110.60 9.68 127 123161 195946 64179498
Torsade de pointes 109.51 9.68 150 123138 17213 64358231
Intentional overdose 108.99 9.68 20 123268 89924 64285520
Fatigue 107.51 9.68 916 122372 747814 63627630
Hand deformity 105.98 9.68 3 123285 62768 64312676
Immunosuppressant drug level increased 105.53 9.68 97 123191 7162 64368282
Plasma cell myeloma 105.35 9.68 256 123032 45819 64329625
Acute graft versus host disease 101.35 9.68 105 123183 8979 64366465
Abdominal discomfort 100.78 9.68 120 123168 182202 64193242
Suicide attempt 99.71 9.68 10 123278 70997 64304447
Acute myeloid leukaemia 98.09 9.68 183 123105 27280 64348164
Blood bilirubin increased 91.71 9.68 280 123008 57273 64318171
Pseudomonas infection 90.21 9.68 139 123149 17744 64357700
Pemphigus 89.42 9.68 7 123281 60694 64314750
Infusion related reaction 89.03 9.68 110 123178 164357 64211087
White blood cell count decreased 88.95 9.68 561 122727 157276 64218168
Acute graft versus host disease in skin 88.93 9.68 86 123202 6769 64368675
Aplastic anaemia 87.40 9.68 120 123168 13800 64361644
Respiratory failure 87.21 9.68 567 122721 160616 64214828
Pain 87.21 9.68 660 122628 552851 63822593
Drug level increased 86.88 9.68 198 123090 33998 64341446
Systemic lupus erythematosus 86.36 9.68 21 123267 77591 64297853
Cytomegalovirus viraemia 86.24 9.68 105 123183 10723 64364721
Disseminated intravascular coagulation 85.19 9.68 190 123098 32158 64343286
Therapeutic product effect incomplete 84.80 9.68 46 123242 103436 64272008
Neurotoxicity 83.75 9.68 171 123117 27233 64348211
Fungaemia 80.59 9.68 63 123225 3722 64371722
Injection site pain 79.62 9.68 58 123230 111350 64264094
Dizziness 77.50 9.68 493 122795 429670 63945774
Staphylococcal infection 77.44 9.68 243 123045 50435 64325009
Bone marrow failure 77.06 9.68 234 123054 47718 64327726
Cystitis haemorrhagic 76.50 9.68 85 123203 7871 64367573
Musculoskeletal stiffness 74.79 9.68 75 123213 123131 64252313
Cryptococcosis 74.65 9.68 53 123235 2702 64372742
Drug reaction with eosinophilia and systemic symptoms 73.87 9.68 250 123038 53967 64321477
Glossodynia 72.98 9.68 17 123271 64679 64310765
Blood pressure increased 72.61 9.68 137 123151 172415 64203029
Fixed eruption 71.47 9.68 47 123241 2112 64373332
Hepatotoxicity 70.89 9.68 202 123086 39760 64335684
Blood lactate dehydrogenase increased 70.56 9.68 179 123109 32899 64342545
Candida sepsis 70.12 9.68 47 123241 2181 64373263
Tumour lysis syndrome 70.00 9.68 130 123158 19310 64356134
Overdose 69.53 9.68 124 123164 159442 64216002
Oesophageal candidiasis 69.21 9.68 81 123207 7936 64367508
Pneumonia 68.97 9.68 1474 121814 558102 63817342
Maternal exposure during pregnancy 68.40 9.68 50 123238 95834 64279610
Toxicity to various agents 67.83 9.68 412 122876 363101 64012343
Product dose omission issue 66.85 9.68 173 123115 194574 64180870
Laryngitis fungal 66.55 9.68 20 123268 120 64375324
Bacteraemia 66.35 9.68 154 123134 26757 64348687
Pneumonia fungal 65.75 9.68 83 123205 8794 64366650
Bacterial sepsis 65.47 9.68 76 123212 7381 64368063
Dyspnoea 64.76 9.68 976 122312 717698 63657746
Myocardial infarction 64.34 9.68 138 123150 165683 64209761
Agranulocytosis 63.73 9.68 189 123099 38040 64337404
Sinusitis fungal 63.54 9.68 40 123248 1666 64373778
Aspartate aminotransferase increased 63.31 9.68 419 122869 119369 64256075
Wound 62.65 9.68 34 123254 76443 64299001
Discomfort 61.94 9.68 39 123249 80839 64294605
Acinetobacter infection 61.86 9.68 45 123243 2384 64373060
Alanine aminotransferase increased 61.63 9.68 466 122822 138565 64236879
Hepatic function abnormal 61.56 9.68 265 123023 64048 64311396
Immune effector cell-associated neurotoxicity syndrome 61.42 9.68 46 123242 2549 64372895
Hypersensitivity 61.12 9.68 183 123105 196269 64179175
Acute generalised exanthematous pustulosis 60.95 9.68 102 123186 13956 64361488
Clostridium difficile colitis 60.88 9.68 150 123138 27073 64348371
Swelling 60.79 9.68 135 123153 160083 64215361
Deep vein thrombosis 60.56 9.68 376 122912 104806 64270638
Leukopenia 60.24 9.68 365 122923 100877 64274567
Wrong technique in product usage process 59.16 9.68 25 123263 64949 64310495
Chronic graft versus host disease 58.54 9.68 66 123222 6210 64369234
Pain in extremity 58.37 9.68 340 122948 302745 64072699
Venoocclusive liver disease 57.91 9.68 83 123205 9932 64365512
Headache 57.80 9.68 691 122597 528776 63846668
Salpingo-oophorectomy unilateral 57.76 9.68 25 123263 471 64374973
Electrocardiogram QT prolonged 56.88 9.68 301 122987 79147 64296297
Neutropenic sepsis 56.09 9.68 132 123156 23140 64352304
Toxic neuropathy 55.07 9.68 28 123260 768 64374676
Mouth ulceration 54.65 9.68 161 123127 32283 64343161
Skin candida 53.78 9.68 36 123252 1667 64373777
Hyperbilirubinaemia 52.99 9.68 122 123166 21083 64354361
Encephalitis 52.90 9.68 90 123198 12481 64362963
Systemic mycosis 52.37 9.68 40 123248 2283 64373161
Hepatic failure 52.06 9.68 227 123061 55167 64320277
Klebsiella infection 51.86 9.68 92 123196 13189 64362255
Inappropriate schedule of product administration 51.75 9.68 60 123228 92226 64283218
Geotrichum infection 51.31 9.68 28 123260 890 64374554
Mobility decreased 50.12 9.68 54 123234 85786 64289658
Loss of personal independence in daily activities 50.11 9.68 39 123249 72415 64303029
Infective aneurysm 49.69 9.68 27 123261 851 64374593
Alopecia 49.64 9.68 157 123131 165533 64209911
Intentional product misuse 48.64 9.68 40 123248 72255 64303189
Pruritus genital 48.26 9.68 28 123260 1004 64374440
Renal failure 48.04 9.68 545 122743 181143 64194301
Acute kidney injury 47.34 9.68 1158 122130 448082 63927362
Hypomagnesaemia 47.13 9.68 168 123120 37208 64338236
Malaise 46.76 9.68 508 122780 395739 63979705
Feeling abnormal 46.35 9.68 118 123170 133484 64241960
Long QT syndrome 46.17 9.68 53 123235 5086 64370358
Acute myeloid leukaemia recurrent 46.01 9.68 40 123248 2744 64372700
Device related infection 46.00 9.68 146 123142 30480 64344964
Weight increased 45.64 9.68 231 123057 213117 64162327
Uterine perforation 45.64 9.68 56 123232 5764 64369680
Female genital tract fistula 45.57 9.68 39 123249 2619 64372825
Helicobacter infection 45.47 9.68 9 123279 38353 64337091
Injection site erythema 45.41 9.68 41 123247 70759 64304685
Cholestasis 43.79 9.68 186 123102 44686 64330758
Engraftment syndrome 43.73 9.68 27 123261 1086 64374358
Duodenal ulcer perforation 43.47 9.68 7 123281 34618 64340826
Injection site swelling 42.60 9.68 13 123275 41340 64334104
Contusion 42.42 9.68 97 123191 113868 64261576
Graft versus host disease in gastrointestinal tract 42.40 9.68 53 123235 5559 64369885
Psoriatic arthropathy 42.14 9.68 15 123273 43266 64332178
Stem cell transplant 42.04 9.68 42 123246 3439 64372005
Penis injury 41.87 9.68 14 123274 124 64375320
HIV infection 41.61 9.68 25 123263 957 64374487
Dermatitis bullous 41.40 9.68 79 123209 11975 64363469
Rash maculo-papular 41.39 9.68 189 123099 46837 64328607
Cytomegalovirus test positive 41.16 9.68 50 123238 5094 64370350
Blood alkaline phosphatase increased 40.81 9.68 214 123074 56065 64319379
Renal impairment 40.79 9.68 416 122872 134601 64240843
Aplasia 40.76 9.68 58 123230 6895 64368549
Insomnia 40.74 9.68 217 123071 197619 64177825
Gait disturbance 40.56 9.68 180 123108 171975 64203469
Hypokalaemia 39.94 9.68 382 122906 121521 64253923
Hyperhidrosis 39.82 9.68 115 123173 124805 64250639
Blood pressure fluctuation 39.73 9.68 25 123263 51846 64323598
Hypertension 39.34 9.68 312 122976 258949 64116495
Respiratory tract infection fungal 39.16 9.68 25 123263 1067 64374377
Liver disorder 38.77 9.68 203 123085 53148 64322296
C-reactive protein abnormal 38.50 9.68 5 123283 29042 64346402
Arthritis 38.45 9.68 63 123225 83751 64291693
Toxoplasmosis 38.16 9.68 34 123254 2410 64373034
Cerebral toxoplasmosis 38.03 9.68 30 123258 1796 64373648
Impaired healing 37.62 9.68 36 123252 60437 64315007
Enterococcal sepsis 37.57 9.68 34 123254 2460 64372984
Cutaneous coccidioidomycosis 37.50 9.68 9 123279 18 64375426
Cachexia 37.48 9.68 65 123223 9152 64366292
Adrenal insufficiency 37.31 9.68 111 123177 22376 64353068
Eosinophilia 37.28 9.68 158 123130 37918 64337526
Pericarditis 36.86 9.68 39 123249 62477 64312967
Enterobacter infection 36.42 9.68 40 123248 3656 64371788
Breast cancer 36.36 9.68 6 123282 29142 64346302
Blood pressure systolic increased 36.30 9.68 25 123263 49428 64326016
Irritable bowel syndrome 36.30 9.68 13 123275 37356 64338088
Clostridium test positive 36.23 9.68 42 123246 4073 64371371
Haemophagocytic lymphohistiocytosis 36.21 9.68 94 123194 17515 64357929
Trichosporon infection 35.97 9.68 22 123266 870 64374574
Dysphagia 35.62 9.68 336 122952 106476 64268968
Penile haemorrhage 35.56 9.68 18 123270 489 64374955
Musculoskeletal pain 35.55 9.68 63 123225 81231 64294213
Disseminated mucormycosis 35.53 9.68 18 123270 490 64374954
Stress 35.42 9.68 38 123250 60496 64314948
Odynophagia 35.37 9.68 65 123223 9576 64365868
Disseminated cryptococcosis 35.37 9.68 27 123261 1540 64373904
Flushing 35.26 9.68 60 123228 78588 64296856
Graft versus host disease in skin 34.94 9.68 47 123241 5300 64370144
Pulmonary haemorrhage 34.51 9.68 77 123211 13032 64362412
Fungal test positive 34.26 9.68 22 123266 949 64374495
Blood culture positive 33.99 9.68 57 123231 7811 64367633
Acute respiratory distress syndrome 33.90 9.68 156 123132 38779 64336665
Gastrointestinal fungal infection 33.89 9.68 16 123272 372 64375072
Ileus paralytic 33.77 9.68 59 123229 8356 64367088
Epstein-Barr virus infection 33.61 9.68 74 123214 12414 64363030
Memory impairment 33.47 9.68 71 123217 85611 64289833
Bradycardia 33.34 9.68 115 123173 118104 64257340
Pseudomembranous colitis 33.33 9.68 44 123244 4872 64370572
Adenovirus infection 33.28 9.68 54 123234 7201 64368243
Blast cell count increased 33.27 9.68 24 123264 1255 64374189
Embolism venous 32.91 9.68 37 123251 3470 64371974
Acute lymphocytic leukaemia 32.58 9.68 41 123247 4330 64371114
Rhinorrhoea 32.54 9.68 40 123248 59929 64315515
Suicidal ideation 32.44 9.68 48 123240 66494 64308950
Cardiac failure congestive 32.30 9.68 134 123154 130446 64244998
International normalised ratio increased 32.10 9.68 260 123028 78907 64296537
Product use issue 32.01 9.68 165 123123 151550 64223894
Staphylococcal sepsis 32.00 9.68 74 123214 12825 64362619
Hyperferritinaemia 31.99 9.68 17 123271 512 64374932
Shock haemorrhagic 31.86 9.68 87 123201 16704 64358740
Enterococcal bacteraemia 31.69 9.68 31 123257 2474 64372970
Mucosal disorder 31.68 9.68 34 123254 3028 64372416
Systemic inflammatory response syndrome 31.42 9.68 64 123224 10171 64365273
Pleural effusion 31.36 9.68 375 122913 126184 64249260
Hypoalbuminaemia 31.01 9.68 89 123199 17585 64357859
Knee arthroplasty 30.63 9.68 7 123281 26992 64348452
Cough 30.38 9.68 401 122887 301747 64073697
Cytomegalovirus chorioretinitis 30.31 9.68 42 123246 4870 64370574
Cytopenia 30.20 9.68 81 123207 15390 64360054
Vulvovaginal candidiasis 30.06 9.68 28 123260 2102 64373342
Respiratory symptom 30.01 9.68 33 123255 3020 64372424
Transplant rejection 29.92 9.68 87 123201 17314 64358130
Staphylococcal bacteraemia 29.74 9.68 63 123225 10292 64365152
Engraft failure 29.70 9.68 17 123271 594 64374850
Accidental exposure to product 29.58 9.68 7 123281 26357 64349087
Erythema multiforme 29.44 9.68 81 123207 15620 64359824
Osteonecrosis of jaw 29.41 9.68 20 123268 39805 64335639
Sleep disorder 29.18 9.68 43 123245 59666 64315778
Differentiation syndrome 28.99 9.68 27 123261 2027 64373417
Fusarium infection 28.92 9.68 24 123264 1545 64373899
Sputum increased 28.54 9.68 35 123253 3600 64371844
Incorrect dose administered 28.50 9.68 45 123243 60720 64314724
Nervous system disorder 28.47 9.68 103 123185 22975 64352469
Red blood cell sedimentation rate increased 28.46 9.68 12 123276 31223 64344221
Dysbiosis 28.45 9.68 19 123269 876 64374568
Intentional self-injury 28.38 9.68 10 123278 29034 64346410
Muscle spasms 28.29 9.68 156 123132 140867 64234577
Jaundice 28.27 9.68 174 123114 48338 64327106
Stenotrophomonas infection 28.06 9.68 32 123256 3048 64372396
Haemodialysis 28.05 9.68 84 123204 16993 64358451
Basal cell carcinoma 27.86 9.68 12 123276 30826 64344618
Jarisch-Herxheimer reaction 27.85 9.68 17 123271 670 64374774
Oropharyngeal candidiasis 27.56 9.68 23 123265 1492 64373952
Heart rate decreased 27.56 9.68 39 123249 55028 64320416
Fungal skin infection 27.49 9.68 41 123247 5084 64370360
Encephalopathy 27.08 9.68 199 123089 58620 64316824
Acute myocardial infarction 27.04 9.68 58 123230 69660 64305784
Nightmare 26.91 9.68 4 123284 20989 64354455
Anaemia 26.83 9.68 929 122359 377751 63997693
Enterobacter test positive 26.83 9.68 14 123274 406 64375038
Symmetrical drug-related intertriginous and flexural exanthema 26.81 9.68 16 123272 605 64374839
Atelectasis 26.58 9.68 113 123175 27153 64348291
Coagulopathy 26.40 9.68 126 123162 31794 64343650
Blood corticosterone increased 26.31 9.68 5 123283 0 64375444
Poisoning 26.21 9.68 5 123283 21874 64353570
Death 26.05 9.68 713 122575 481992 63893452
Myalgia 25.88 9.68 187 123101 158430 64217014
Pseudomonal sepsis 25.80 9.68 40 123248 5132 64370312
Neutrophilic dermatosis 25.80 9.68 15 123273 540 64374904
Gamma-glutamyltransferase increased 25.80 9.68 170 123118 48340 64327104
Disease recurrence 25.79 9.68 124 123164 31386 64344058
Fungal sepsis 25.76 9.68 23 123265 1635 64373809
Fungal oesophagitis 25.49 9.68 17 123271 782 64374662
Toxic skin eruption 25.45 9.68 88 123200 19196 64356248
Philadelphia positive acute lymphocytic leukaemia 25.44 9.68 8 123280 57 64375387
Post procedural bile leak 25.42 9.68 13 123275 361 64375083
Candida test positive 25.40 9.68 19 123269 1051 64374393
Injection site pruritus 25.35 9.68 21 123267 37805 64337639
Epidermolysis bullosa 25.33 9.68 11 123277 209 64375235
Fibromyalgia 25.00 9.68 19 123269 35712 64339732
Mycobacterium avium complex infection 24.78 9.68 34 123254 3906 64371538
Haematotoxicity 24.65 9.68 67 123221 12829 64362615
Pneumonia pseudomonal 24.57 9.68 38 123250 4865 64370579
Coronary artery disease 24.51 9.68 49 123239 60384 64315060
Pain in jaw 24.50 9.68 25 123263 40730 64334714
Sepsis syndrome 24.45 9.68 20 123268 1261 64374183
Somnolence 24.40 9.68 260 123028 203385 64172059
Myelodysplastic syndrome 24.38 9.68 111 123177 27468 64347976
Haemodynamic instability 24.16 9.68 73 123215 14839 64360605
Therapeutic response decreased 24.14 9.68 39 123249 52149 64323295
Intentional product use issue 24.12 9.68 97 123191 95267 64280177
Cholecystitis chronic 23.83 9.68 54 123234 9233 64366211
Tonsillar haemorrhage 23.77 9.68 11 123277 244 64375200
Lymphocyte count decreased 23.73 9.68 146 123142 40553 64334891
Cerebrovascular accident 23.52 9.68 160 123128 137423 64238021
Chronic hepatitis C 23.46 9.68 14 123274 529 64374915
Injection site bruising 23.40 9.68 21 123267 36352 64339092
Abscess neck 23.36 9.68 18 123270 1041 64374403
Respiratory moniliasis 23.29 9.68 11 123277 256 64375188
Gastrointestinal mucormycosis 23.25 9.68 12 123276 340 64375104
Diastolic dysfunction 23.22 9.68 52 123236 8823 64366621
Nephropathy toxic 23.18 9.68 80 123208 17434 64358010
Graft versus host disease in lung 23.02 9.68 16 123272 788 64374656
Stenotrophomonas test positive 23.02 9.68 12 123276 347 64375097
Intracranial pressure increased 23.01 9.68 45 123243 6944 64368500
Vaginal discharge 22.93 9.68 33 123255 3964 64371480
Pulmonary mucormycosis 22.88 9.68 16 123272 796 64374648
Thrombotic microangiopathy 22.85 9.68 77 123211 16578 64358866
Blood creatinine increased 22.60 9.68 375 122913 135407 64240037
Coccidioidomycosis 22.55 9.68 18 123270 1096 64374348
Acute graft versus host disease in intestine 22.48 9.68 31 123257 3578 64371866
Neuropathy peripheral 22.38 9.68 332 122956 117193 64258251
Nasal polyps 22.35 9.68 31 123257 3598 64371846
Drug ineffective for unapproved indication 22.30 9.68 118 123170 31015 64344429
Hypertensive crisis 22.22 9.68 4 123284 18244 64357200
Encephalitis viral 22.15 9.68 25 123263 2355 64373089
Extravasation blood 22.12 9.68 12 123276 377 64375067
Proteus infection 22.04 9.68 21 123267 1622 64373822
Focal myositis 21.96 9.68 6 123282 24 64375420
Road traffic accident 21.96 9.68 16 123272 30729 64344715
Acquired immunodeficiency syndrome 21.94 9.68 10 123278 214 64375230
Vaginal infection 21.73 9.68 36 123252 4884 64370560
Oral fungal infection 21.69 9.68 28 123260 3033 64372411
Growth failure 21.68 9.68 10 123278 220 64375224
Generalised oedema 21.56 9.68 88 123200 20765 64354679
Joint stiffness 21.49 9.68 16 123272 30388 64345056
Drug-induced liver injury 21.26 9.68 160 123128 47483 64327961
Ill-defined disorder 21.26 9.68 32 123256 44020 64331424
Nasal congestion 21.22 9.68 52 123236 59606 64315838
Fracture 21.00 9.68 5 123283 18750 64356694
Limb discomfort 20.94 9.68 13 123275 27162 64348282
Exposure via breast milk 20.88 9.68 15 123273 779 64374665
Nosocomial infection 20.85 9.68 25 123263 2512 64372932
Oral disorder 20.84 9.68 50 123238 8871 64366573
Pseudomonas test positive 20.74 9.68 20 123268 1568 64373876
Oesophagitis 20.59 9.68 89 123199 21541 64353903
Irritability 20.48 9.68 24 123264 36722 64338722
Multiple-drug resistance 20.37 9.68 41 123247 6461 64368983
Sinus polyp 20.34 9.68 12 123276 444 64375000
Bacterial infection 20.28 9.68 98 123190 24852 64350592
Balance disorder 20.21 9.68 87 123201 83839 64291605
Aortoenteric fistula 20.14 9.68 8 123280 120 64375324
Sedation 20.12 9.68 30 123258 41432 64334012
Klebsiella sepsis 20.11 9.68 25 123263 2607 64372837
Arthritis fungal 20.08 9.68 8 123280 121 64375323
BK virus infection 20.03 9.68 44 123244 7368 64368076
Neurological symptom 19.99 9.68 42 123246 6822 64368622
Right ventricular failure 19.97 9.68 8 123280 21463 64353981
Portal fibrosis 19.91 9.68 13 123275 577 64374867
Wound infection fungal 19.90 9.68 9 123279 189 64375255
Liver abscess 19.88 9.68 36 123252 5244 64370200
Porphyria acute 19.85 9.68 14 123274 706 64374738
Medication error 19.85 9.68 41 123247 49925 64325519
Adverse event 19.72 9.68 28 123260 39461 64335983
Myelosuppression 19.66 9.68 94 123194 23736 64351708
Injection site reaction 19.65 9.68 37 123251 46627 64328817
Musculoskeletal disorder 19.61 9.68 5 123283 17901 64357543
Skin lesion 19.49 9.68 128 123160 36354 64339090
Feeling hot 19.41 9.68 36 123252 45627 64329817
Ventricular tachycardia 19.40 9.68 122 123166 34143 64341301
Aspartate aminotransferase 19.31 9.68 9 123279 203 64375241
Cushingoid 19.28 9.68 44 123244 7559 64367885
Metabolic acidosis 19.25 9.68 214 123074 70744 64304700
Diabetic macroangiopathy 19.07 9.68 8 123280 139 64375305
Fluorosis 19.04 9.68 7 123281 84 64375360
Septic embolus 19.00 9.68 20 123268 1742 64373702
Influenza like illness 18.79 9.68 58 123230 61644 64313800
Dysarthria 18.70 9.68 55 123233 59351 64316093
Streptococcal infection 18.65 9.68 43 123245 7436 64368008
Injury 18.59 9.68 176 123112 55816 64319628
Hepatocellular injury 18.57 9.68 149 123139 45086 64330358
Nasal abscess 18.52 9.68 8 123280 150 64375294
Choreoathetosis 18.48 9.68 18 123270 1429 64374015
CD4 lymphocytes decreased 18.40 9.68 23 123265 2412 64373032
Wound dehiscence 18.35 9.68 37 123251 5837 64369607
Overgrowth fungal 18.33 9.68 7 123281 94 64375350
Drug dependence 18.30 9.68 22 123266 33290 64342154
Tongue blistering 18.26 9.68 17 123271 1276 64374168
Nail infection 18.22 9.68 20 123268 1827 64373617
Oral pain 18.21 9.68 102 123186 27391 64348053
Gastrointestinal disorder 18.12 9.68 99 123189 89610 64285834
Psoriasis 18.09 9.68 73 123215 71630 64303814
Diffuse large B-cell lymphoma 18.01 9.68 52 123236 10309 64365135
Angina pectoris 17.90 9.68 37 123251 45044 64330400
Hepatitis fulminant 17.82 9.68 38 123250 6236 64369208
Encephalitis fungal 17.82 9.68 8 123280 165 64375279
Peripheral sensory neuropathy 17.78 9.68 55 123233 11323 64364121
Pneumonia influenzal 17.76 9.68 23 123265 2499 64372945
Pulmonary embolism 17.74 9.68 385 122903 145971 64229473
Enterococcus test positive 17.67 9.68 19 123269 1696 64373748
Oxygen saturation decreased 17.65 9.68 126 123162 107050 64268394
Drug eruption 17.64 9.68 124 123164 36012 64339432
Mycetoma mycotic 17.63 9.68 7 123281 105 64375339
Dystonia 17.59 9.68 7 123281 18858 64356586
Virologic failure 17.56 9.68 27 123261 3439 64372005
Cardio-respiratory arrest 17.53 9.68 113 123175 98280 64277164
Venoocclusive disease 17.39 9.68 29 123259 3956 64371488
Nocardiosis 17.31 9.68 32 123256 4735 64370709
Restlessness 17.24 9.68 31 123257 39754 64335690
Multiple sclerosis relapse 16.99 9.68 33 123255 41102 64334342
Neutropenic colitis 16.95 9.68 31 123257 4550 64370894
Epstein-Barr viraemia 16.93 9.68 19 123269 1778 64373666
Back pain 16.91 9.68 357 122931 249814 64125630
Injection site mass 16.78 9.68 6 123282 17264 64358180
Blood cholesterol increased 16.76 9.68 45 123243 50021 64325423
T-cell lymphoma recurrent 16.71 9.68 6 123282 67 64375377
Hot flush 16.68 9.68 40 123248 46195 64329249
Inhibitory drug interaction 16.64 9.68 27 123261 3600 64371844
Asthma 16.64 9.68 110 123178 95115 64280329
Skin oedema 16.63 9.68 17 123271 1431 64374013
SARS-CoV-2 sepsis 16.46 9.68 7 123281 126 64375318
Colitis 16.39 9.68 178 123110 58496 64316948
Acanthosis 16.34 9.68 10 123278 396 64375048
HIV associated nephropathy 16.33 9.68 9 123279 292 64375152
Injection site warmth 16.29 9.68 3 123285 13459 64361985
Mediastinitis 16.22 9.68 13 123275 796 64374648
Pulmonary infarction 16.19 9.68 25 123263 3197 64372247
Respiratory distress 16.15 9.68 162 123126 52169 64323275
Fluid retention 16.12 9.68 59 123229 59547 64315897
Dry eye 16.12 9.68 19 123269 29000 64346444
Puerperal pyrexia 16.10 9.68 5 123283 34 64375410
Disease progression 16.01 9.68 369 122919 141311 64234133
Angioimmunoblastic T-cell lymphoma 15.96 9.68 10 123278 413 64375031
Hyperadrenocorticism 15.92 9.68 9 123279 307 64375137
Weight decreased 15.91 9.68 420 122868 285319 64090125
Acid base balance abnormal 15.89 9.68 9 123279 308 64375136
Cytomegalovirus gastroenteritis 15.83 9.68 10 123278 419 64375025
Limb injury 15.81 9.68 13 123275 23492 64351952
Withdrawal syndrome 15.79 9.68 13 123275 23479 64351965
Tongue coated 15.79 9.68 15 123273 1155 64374289
Vulvovaginal disorder 15.79 9.68 3 123285 0 64375444
Leukaemia recurrent 15.74 9.68 22 123266 2572 64372872
Chronic lymphocytic leukaemia 15.71 9.68 29 123259 4286 64371158
Depression 15.69 9.68 251 123037 183040 64192404
Arteritis infective 15.68 9.68 6 123282 81 64375363
Culture stool positive 15.65 9.68 11 123277 552 64374892
Plasma cell leukaemia 15.64 9.68 17 123271 1536 64373908
Hepatitis cholestatic 15.63 9.68 55 123233 12100 64363344
Paraesthesia 15.60 9.68 173 123115 134349 64241095
Prothrombin time shortened 15.58 9.68 23 123265 2826 64372618
Bursitis 15.58 9.68 11 123277 21474 64353970
Antithrombin III decreased 15.58 9.68 10 123278 431 64375013
Abdominal pain upper 15.55 9.68 238 123050 174792 64200652
Asthenia 15.43 9.68 665 122623 427379 63948065
Macule 15.36 9.68 21 123267 2405 64373039
Cerebral fungal infection 15.33 9.68 9 123279 330 64375114
Influenza 15.31 9.68 130 123158 106401 64269043
Cognitive disorder 15.25 9.68 54 123234 55033 64320411
Type 2 diabetes mellitus 15.20 9.68 26 123262 33994 64341450
Genital haemorrhage 15.17 9.68 33 123255 5489 64369955
Respiratory syncytial virus infection 15.15 9.68 39 123249 7229 64368215
Abscess 15.10 9.68 75 123213 19229 64356215
Brain abscess 15.10 9.68 28 123260 4153 64371291
Urinary tract infection fungal 15.08 9.68 13 123275 882 64374562
Coagulation factor V level decreased 15.03 9.68 11 123277 588 64374856
Hyperleukocytosis 14.99 9.68 19 123269 2021 64373423
Blood glucose increased 14.86 9.68 118 123170 97955 64277489
Anaphylactic reaction 14.86 9.68 74 123214 68590 64306854
Cytomegalovirus oesophagitis 14.85 9.68 11 123277 599 64374845
Anal candidiasis 14.84 9.68 4 123284 15 64375429
Hepatic cirrhosis 14.84 9.68 17 123271 26281 64349163
IVth nerve paralysis 14.82 9.68 7 123281 163 64375281
Epidermolysis 14.81 9.68 10 123278 470 64374974
Stiff person syndrome 14.67 9.68 8 123280 254 64375190
PRIDE syndrome 14.64 9.68 4 123284 16 64375428
Lymphadenopathy 14.64 9.68 145 123143 46541 64328903
Rhinocerebral mucormycosis 14.64 9.68 10 123278 479 64374965
Presyncope 14.62 9.68 28 123260 35061 64340383
Throat irritation 14.61 9.68 25 123263 32686 64342758
Clostridial infection 14.53 9.68 31 123257 5088 64370356
Prostate cancer 14.53 9.68 10 123278 19785 64355659
Mastitis fungal 14.45 9.68 4 123284 17 64375427
Cytomegalovirus test 14.42 9.68 5 123283 50 64375394
Central nervous system leukaemia 14.27 9.68 9 123279 376 64375068
Rash erythematous 14.27 9.68 149 123139 48484 64326960
Pharyngeal stenosis 14.26 9.68 4 123284 18 64375426
Lung neoplasm malignant 14.26 9.68 12 123276 21436 64354008
Acute febrile neutrophilic dermatosis 14.23 9.68 24 123264 3305 64372139
Device malfunction 14.20 9.68 8 123280 17625 64357819
Adrenal suppression 14.20 9.68 15 123273 1312 64374132
Chest pain 14.17 9.68 343 122945 235637 64139807
Lung infiltration 14.16 9.68 78 123210 20811 64354633
Heart rate irregular 14.13 9.68 19 123269 27394 64348050
Gastrointestinal wall thinning 14.09 9.68 4 123284 19 64375425
Dermatitis 14.07 9.68 70 123218 17959 64357485
Vulvovaginitis 14.07 9.68 8 123280 276 64375168
Product storage error 14.06 9.68 4 123284 13314 64362130
Epstein-Barr virus associated lymphoproliferative disorder 14.02 9.68 23 123265 3096 64372348
Mediastinal effusion 13.99 9.68 5 123283 55 64375389
Gastritis fungal 13.97 9.68 7 123281 186 64375258
Product prescribing error 13.96 9.68 29 123259 35240 64340204
Blood beta-D-glucan increased 13.94 9.68 10 123278 518 64374926
Peritoneal candidiasis 13.92 9.68 4 123284 20 64375424
Osteoarthritis 13.85 9.68 68 123220 63268 64312176
Pulmonary cavitation 13.85 9.68 15 123273 1350 64374094
Blood sodium decreased 13.71 9.68 100 123188 29382 64346062
Vaginal mucosal blistering 13.71 9.68 3 123285 3 64375441
Infection 13.68 9.68 456 122832 184424 64191020
Unevaluable event 13.64 9.68 50 123238 50439 64325005
Petechiae 13.62 9.68 71 123217 18555 64356889
Gallstone ileus 13.60 9.68 4 123284 22 64375422
Shock 13.60 9.68 122 123166 38118 64337326
Chest discomfort 13.59 9.68 149 123139 115957 64259487
Staphylococcus test positive 13.58 9.68 32 123256 5613 64369831
Hypophosphataemia 13.58 9.68 60 123228 14660 64360784
Platelet transfusion 13.52 9.68 17 123271 1794 64373650
Ocular icterus 13.48 9.68 30 123258 5068 64370376
Respiratory paralysis 13.45 9.68 5 123283 62 64375382
Product administration error 13.41 9.68 20 123268 27623 64347821
Bronchitis 13.35 9.68 138 123150 108605 64266839
Middle insomnia 13.35 9.68 4 123284 12873 64362571
Pulmonary alveolar haemorrhage 13.34 9.68 45 123243 9693 64365751
Dementia 13.34 9.68 12 123276 20754 64354690
Ischaemic hepatitis 13.34 9.68 23 123265 3223 64372221
Liver transplant rejection 13.32 9.68 22 123266 2977 64372467
Anticonvulsant drug level abnormal 13.24 9.68 5 123283 65 64375379
Underdose 13.21 9.68 18 123270 25811 64349633
Posterior reversible encephalopathy syndrome 13.17 9.68 82 123206 22864 64352580
Bone erosion 13.17 9.68 3 123285 11592 64363852
Product substitution issue 13.14 9.68 9 123279 17852 64357592
Mucosal infection 13.08 9.68 9 123279 436 64375008
Eye irritation 13.05 9.68 7 123281 15849 64359595
Central nervous system lesion 13.05 9.68 51 123237 11798 64363646
Heart rate increased 13.05 9.68 123 123165 98552 64276892
HIV-associated neurocognitive disorder 13.04 9.68 8 123280 318 64375126
Aggression 13.01 9.68 45 123243 46187 64329257
Ureaplasma infection 13.00 9.68 11 123277 727 64374717
Faeces pale 12.99 9.68 20 123268 2551 64372893
Adverse drug reaction 12.96 9.68 44 123244 45420 64330024
Streptococcal bacteraemia 12.96 9.68 22 123266 3045 64372399
Hip arthroplasty 12.94 9.68 13 123275 21338 64354106
Skin exfoliation 12.92 9.68 137 123151 44748 64330696
Anger 12.88 9.68 7 123281 15734 64359710
Interstitial lung disease 12.85 9.68 122 123166 97610 64277834
Gram stain positive 12.85 9.68 6 123282 136 64375308
Muscle spasticity 12.81 9.68 8 123280 16661 64358783
Cerebral aspergillosis 12.81 9.68 16 123272 1677 64373767
Hepatomegaly 12.79 9.68 65 123223 16817 64358627
Gastrointestinal necrosis 12.78 9.68 29 123259 4963 64370481
Autoimmune haemolytic anaemia 12.77 9.68 36 123252 7040 64368404
Oedema genital 12.74 9.68 9 123279 455 64374989
Application site haematoma 12.71 9.68 5 123283 73 64375371
Organ failure 12.71 9.68 24 123264 3609 64371835
Cardiovascular insufficiency 12.68 9.68 20 123268 2604 64372840
Angiodermatitis 12.65 9.68 5 123283 74 64375370
Angioedema 12.60 9.68 68 123220 61753 64313691
Hepatosplenomegaly 12.54 9.68 30 123258 5313 64370131
Fat necrosis 12.54 9.68 11 123277 764 64374680
Blood albumin decreased 12.54 9.68 76 123212 20997 64354447
Erythroblast count increased 12.50 9.68 3 123285 6 64375438
Cushing's syndrome 12.47 9.68 12 123276 939 64374505
Chronic obstructive pulmonary disease 12.45 9.68 82 123206 70966 64304478
Infective chondritis 12.43 9.68 4 123284 31 64375413
Hysterectomy 12.42 9.68 29 123259 5056 64370388
Hallucination, tactile 12.42 9.68 9 123279 474 64374970
Leukaemia 12.41 9.68 29 123259 5059 64370385
Citrobacter infection 12.37 9.68 11 123277 778 64374666
Graft versus host disease in liver 12.36 9.68 15 123273 1526 64373918
Injection site haemorrhage 12.34 9.68 17 123271 24261 64351183
Chronic sinusitis 12.34 9.68 33 123255 6259 64369185
Blastomycosis 12.24 9.68 9 123279 485 64374959
Cytomegalovirus enterocolitis 12.21 9.68 14 123274 1341 64374103
Kidney transplant rejection 12.20 9.68 43 123245 9468 64365976
Cardiac disorder 12.16 9.68 60 123228 55756 64319688
Drug withdrawal syndrome 12.16 9.68 26 123262 31265 64344179
Gastrooesophageal reflux disease 12.16 9.68 101 123187 83042 64292402
Brain oedema 12.12 9.68 78 123210 21997 64353447
Impaired work ability 12.12 9.68 7 123281 15212 64360232
Pneumonia klebsiella 12.11 9.68 25 123263 4012 64371432
Klebsiella test positive 12.09 9.68 14 123274 1356 64374088
Delusion 12.07 9.68 10 123278 18004 64357440
Sopor 12.07 9.68 24 123264 29637 64345807
Tarsal tunnel syndrome 12.06 9.68 9 123279 496 64374948
Hypoxia 12.03 9.68 236 123052 87913 64287531
Hepatic artery aneurysm 12.01 9.68 4 123284 35 64375409
Aplasia pure red cell 11.99 9.68 35 123253 6979 64368465
Purpura senile 11.96 9.68 9 123279 502 64374942
Herpes simplex oesophagitis 11.96 9.68 7 123281 255 64375189
Superinfection bacterial 11.94 9.68 13 123275 1177 64374267
Metastases to liver 11.93 9.68 17 123271 23924 64351520
Immunosuppressant drug level decreased 11.93 9.68 16 123272 1799 64373645
Retroviral infection 11.90 9.68 3 123285 8 64375436
Graft loss 11.89 9.68 12 123276 995 64374449
Meningitis 11.87 9.68 39 123249 8290 64367154
Enterocolitis 11.86 9.68 50 123238 11968 64363476
Fibrin degradation products increased 11.82 9.68 7 123281 261 64375183
Metastases to bone 11.76 9.68 13 123275 20422 64355022
Dermatitis exfoliative 11.76 9.68 45 123243 10307 64365137
Folliculitis 11.68 9.68 25 123263 30052 64345392
Migraine 11.67 9.68 71 123217 62606 64312838
Osteomyelitis fungal 11.65 9.68 7 123281 268 64375176
Blood fibrinogen increased 11.65 9.68 15 123273 1621 64373823
Gallbladder fibrosis 11.64 9.68 3 123285 9 64375435
Psychotic disorder 11.63 9.68 31 123257 34547 64340897
Hospitalisation 11.62 9.68 90 123198 75117 64300327
Duodenal stenosis 11.60 9.68 10 123278 678 64374766
Periostitis 11.57 9.68 9 123279 528 64374916
Viral test positive 11.55 9.68 8 123280 392 64375052
Escherichia sepsis 11.54 9.68 35 123253 7130 64368314
Respiratory arrest 11.52 9.68 57 123231 52928 64322516
Secondary adrenocortical insufficiency 11.51 9.68 18 123270 2327 64373117
Pneumonia cryptococcal 11.51 9.68 13 123275 1226 64374218
Prothrombin time prolonged 11.50 9.68 60 123228 15681 64359763
Cystic fibrosis related diabetes 11.47 9.68 6 123282 175 64375269
Pulmonary fibrosis 11.46 9.68 25 123263 29853 64345591
Vulvovaginal pruritus 11.45 9.68 16 123272 1870 64373574
Loss of consciousness 11.45 9.68 207 123081 148158 64227286
Lichenification 11.43 9.68 10 123278 692 64374752
Stoma site candida 11.41 9.68 3 123285 10 64375434
Ankle fracture 11.39 9.68 7 123281 14703 64360741
Drug level above therapeutic 11.39 9.68 34 123254 6867 64368577
Splenic vein thrombosis 11.38 9.68 10 123278 696 64374748
Red blood cell schistocytes present 11.38 9.68 9 123279 541 64374903
Necrotising retinitis 11.34 9.68 12 123276 1051 64374393
Hyperuricaemia 11.33 9.68 44 123244 10147 64365297
Herpes simplex 11.32 9.68 45 123243 10491 64364953
Escherichia bacteraemia 11.27 9.68 29 123259 5374 64370070
Neuroleptic malignant syndrome 11.26 9.68 19 123269 24977 64350467
Rash pustular 11.26 9.68 43 123245 9842 64365602
Flatulence 11.24 9.68 33 123255 35633 64339811
Syncope 11.22 9.68 223 123065 157412 64218032
Gallbladder disorder 11.15 9.68 63 123225 16967 64358477
Sinusitis 11.14 9.68 204 123084 145724 64229720
Renal abscess 11.06 9.68 11 123277 896 64374548
Meningitis coccidioides 11.03 9.68 4 123284 46 64375398
Skin maceration 11.03 9.68 4 123284 46 64375398
Stomatitis 11.03 9.68 281 123007 109324 64266120
Nausea 11.00 9.68 1325 121963 784475 63590969
Poor quality sleep 10.97 9.68 12 123276 18939 64356505
Blood pressure diastolic decreased 10.95 9.68 16 123272 22285 64353159
Vertigo 10.91 9.68 67 123221 58944 64316500
Eye disorder 10.86 9.68 12 123276 18857 64356587
Hypoglossal nerve paresis 10.84 9.68 5 123283 110 64375334
Splenomegaly 10.83 9.68 65 123223 17896 64357548
Visual impairment 10.82 9.68 90 123198 73987 64301457
Renal tubular acidosis 10.82 9.68 20 123268 2959 64372485
Xanthopsia 10.82 9.68 7 123281 306 64375138
Rhinovirus infection 10.80 9.68 31 123257 6125 64369319
Transmission of an infectious agent via transplant 10.79 9.68 3 123285 13 64375431
Red cell distribution width increased 10.79 9.68 5 123283 12304 64363140
Pulmonary arterial hypertension 10.78 9.68 20 123268 25347 64350097
Joint injury 10.75 9.68 17 123271 22930 64352514
Angina bullosa haemorrhagica 10.74 9.68 6 123282 200 64375244
Eschar 10.73 9.68 12 123276 1119 64374325
Scopulariopsis infection 10.68 9.68 5 123283 114 64375330
Vulvovaginal discomfort 10.67 9.68 14 123274 1541 64373903
Head injury 10.63 9.68 30 123258 32812 64342632
Hepatic necrosis 10.61 9.68 38 123250 8435 64367009
Hepatic cytolysis 10.58 9.68 54 123234 13995 64361449
Vulvovaginal swelling 10.58 9.68 7 123281 318 64375126
Prescribed overdose 10.57 9.68 14 123274 20317 64355127
Acquired macroglossia 10.55 9.68 6 123282 207 64375237
Emphysema 10.54 9.68 54 123234 14015 64361429
Escherichia infection 10.53 9.68 57 123231 15111 64360333
Tendonitis 10.51 9.68 14 123274 20268 64355176
Premature delivery 10.51 9.68 12 123276 18577 64356867
Anxiety 10.47 9.68 301 122987 202348 64173096
Thrombophlebitis 10.43 9.68 29 123259 5625 64369819
Carpal tunnel syndrome 10.35 9.68 9 123279 15819 64359625
Anaphylactic shock 10.34 9.68 27 123261 30301 64345143
Spinal cord injury thoracic 10.33 9.68 5 123283 123 64375321
Bone marrow disorder 10.30 9.68 19 123269 2806 64372638
Chronic graft versus host disease in skin 10.29 9.68 13 123275 1378 64374066
Sputum abnormal 10.28 9.68 11 123277 976 64374468
Aeromonas infection 10.27 9.68 7 123281 334 64375110
Lymphopenia 10.25 9.68 84 123204 25573 64349871
Blood chloride increased 10.25 9.68 26 123262 4777 64370667
SJS-TEN overlap 10.23 9.68 8 123280 473 64374971
Peripheral sensorimotor neuropathy 10.21 9.68 18 123270 2567 64372877
Klebsiella bacteraemia 10.17 9.68 17 123271 2323 64373121
Idiosyncratic drug reaction 10.16 9.68 12 123276 1187 64374257
Acanthamoeba infection 10.15 9.68 8 123280 478 64374966
Vision blurred 10.14 9.68 117 123171 90199 64285245
Iatrogenic infection 10.13 9.68 4 123284 59 64375385
Nephrolithiasis 10.08 9.68 46 123242 43637 64331807
Foot deformity 10.06 9.68 10 123278 16494 64358950
Haemorrhage 10.02 9.68 210 123078 79141 64296303
Trichoglossia 10.01 9.68 7 123281 348 64375096
Allergic transfusion reaction 10.01 9.68 4 123284 61 64375383
Autonomic neuropathy 10.01 9.68 14 123274 1638 64373806
Muscle necrosis 9.97 9.68 12 123276 1211 64374233
Osteopenia 9.96 9.68 9 123279 15531 64359913
Gastric disorder 9.95 9.68 26 123262 29171 64346273
Myocarditis toxoplasmal 9.95 9.68 4 123284 62 64375382
Urinary tract candidiasis 9.93 9.68 9 123279 652 64374792
Seasonal allergy 9.91 9.68 5 123283 11721 64363723
Fungal endocarditis 9.90 9.68 8 123280 496 64374948
Streptococcal sepsis 9.90 9.68 17 123271 2375 64373069
Oral mucosal erythema 9.90 9.68 14 123274 1655 64373789
Multiple sclerosis 9.89 9.68 13 123275 18928 64356516
Pulmonary hilum mass 9.84 9.68 6 123282 236 64375208
Chronic myeloid leukaemia transformation 9.84 9.68 6 123282 236 64375208
Cardiomyopathy acute 9.84 9.68 6 123282 236 64375208
Refractory anaemia with an excess of blasts 9.84 9.68 10 123278 836 64374608
Infection in an immunocompromised host 9.83 9.68 11 123277 1026 64374418
Blood fibrinogen decreased 9.81 9.68 13 123275 1445 64373999
Product use in unapproved indication 9.80 9.68 422 122866 176196 64199248
Mania 9.78 9.68 10 123278 16276 64359168
Hepatitis acute 9.76 9.68 51 123237 13338 64362106
Emotional disorder 9.76 9.68 6 123282 12601 64362843
Heparin-induced thrombocytopenia 9.75 9.68 37 123251 8442 64367002

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 59.06 40.24 34 200 883 83561

Pharmacologic Action:

SourceCodeDescription
ATC D01AC15 DERMATOLOGICALS
ANTIFUNGALS FOR DERMATOLOGICAL USE
ANTIFUNGALS FOR TOPICAL USE
Imidazole and triazole derivatives
ATC J01RA07 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
COMBINATIONS OF ANTIBACTERIALS
Combinations of antibacterials
ATC J02AC01 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIMYCOTICS FOR SYSTEMIC USE
ANTIMYCOTICS FOR SYSTEMIC USE
Triazole and tetrazole derivatives
FDA CS M0002083 Azoles
FDA EPC N0000175487 Azole Antifungal
FDA MoA N0000182140 Cytochrome P450 2C19 Inhibitors
FDA MoA N0000182141 Cytochrome P450 3A4 Inhibitors
FDA MoA N0000185504 Cytochrome P450 2C9 Inhibitors
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:50183 P450 inhibitors
CHEBI has role CHEBI:78298 environmental contaminants
MeSH PA D058888 14-alpha Demethylase Inhibitors
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000935 Antifungal Agents
MeSH PA D065689 Cytochrome P-450 CYP2C19 Inhibitors
MeSH PA D065688 Cytochrome P-450 CYP2C9 Inhibitors
MeSH PA D065607 Cytochrome P-450 Enzyme Inhibitors
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D006727 Hormone Antagonists
MeSH PA D065606 Metabolic Side Effects of Drugs and Substances
MeSH PA D065088 Steroid Synthesis Inhibitors

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Cryptococcal meningitis indication 14232007
Candidiasis of the esophagus indication 20639004 DOID:13146
Mucocutaneous candidiasis indication 29147005
Disseminated candidiasis indication 70572005
Candidal vulvovaginitis indication 72605008 DOID:2272
Candidiasis of mouth indication 79740000 DOID:14262
Candidal septicemia indication 187022007
Candidemia indication 432261003
Prevention of Disseminated Candidiasis indication
Candidal Urinary Tract Infection indication
Oropharyngeal Candidiasis indication
Tinea capitis off-label use 5441008
Tinea pedis off-label use 6020002 DOID:12403
Histoplasmosis off-label use 12962009 DOID:1731
Tinea manus off-label use 48971001 DOID:13369
Pityriasis versicolor off-label use 56454009 DOID:9060
Blastomycosis off-label use 69996000 DOID:12663
Tinea corporis off-label use 84849002
Disseminated coccidioidomycosis off-label use 85055004
Cutaneous leishmaniasis off-label use 240637006 DOID:9111
Tinea cruris off-label use 399029005
Onychomycosis due to dermatophyte off-label use 402134005
Pulmonary coccidioidomycosis off-label use 417018008
Onychomycosis due to Candida off-label use
Prevention of Vulvovaginal Candidiasis off-label use
Kidney disease contraindication 90708001 DOID:557
Prolonged QT interval contraindication 111975006
Disease of liver contraindication 235856003 DOID:409
Pregnancy, function contraindication 289908002
Congenital long QT syndrome contraindication 442917000




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.55 acidic
pKa2 1.84 Basic
pKa3 1.24 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Cytochrome P450 2C9 Enzyme IC50 4.54 CHEMBL
Cytochrome P450 2C19 Enzyme IC50 5.09 CHEMBL
Lanosterol 14-alpha demethylase Enzyme Kd 4.40 CHEMBL
Cytochrome P450 3A4 Enzyme IC50 5.10 CHEMBL
Lanosterol 14-alpha demethylase Enzyme INHIBITOR IC50 6.70 WOMBAT-PK CHEMBL
Lanosterol 14-alpha demethylase Enzyme Kd 6.70 CHEMBL
14-alpha sterol demethylase Cyp51A Enzyme Kd 4.92 CHEMBL
14-alpha sterol demethylase Enzyme Kd 5.39 CHEMBL
Mycocyclosin synthase Enzyme Kd 5.22 CHEMBL
Sterol 14-alpha demethylase Enzyme IC50 6.06 CHEMBL

External reference:

IDSource
4019493 VUID
N0000147613 NUI
D00322 KEGG_DRUG
4019493 VANDF
C0016277 UMLSCUI
CHEBI:46081 CHEBI
TPF PDB_CHEM_ID
CHEMBL106 ChEMBL_ID
DB00196 DRUGBANK_ID
D015725 MESH_DESCRIPTOR_UI
3365 PUBCHEM_CID
5851 INN_ID
8VZV102JFY UNII
202813 RXNORM
3884 MMSL
4732 MMSL
59176 MMSL
d00071 MMSL
003534 NDDF
31865003 SNOMEDCT_US
387174006 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Diflucan HUMAN PRESCRIPTION DRUG LABEL 1 0049-3410 TABLET 50 mg ORAL NDA 27 sections
Diflucan HUMAN PRESCRIPTION DRUG LABEL 1 0049-3410 TABLET 50 mg ORAL NDA 27 sections
Diflucan HUMAN PRESCRIPTION DRUG LABEL 1 0049-3420 TABLET 100 mg ORAL NDA 27 sections
Diflucan HUMAN PRESCRIPTION DRUG LABEL 1 0049-3420 TABLET 100 mg ORAL NDA 27 sections
Diflucan HUMAN PRESCRIPTION DRUG LABEL 1 0049-3430 TABLET 200 mg ORAL NDA 27 sections
Diflucan HUMAN PRESCRIPTION DRUG LABEL 1 0049-3430 TABLET 200 mg ORAL NDA 27 sections
Diflucan HUMAN PRESCRIPTION DRUG LABEL 1 0049-3440 POWDER, FOR SUSPENSION 350 mg ORAL NDA 27 sections
Diflucan HUMAN PRESCRIPTION DRUG LABEL 1 0049-3440 POWDER, FOR SUSPENSION 350 mg ORAL NDA 27 sections
Diflucan HUMAN PRESCRIPTION DRUG LABEL 1 0049-3450 POWDER, FOR SUSPENSION 1400 mg ORAL NDA 27 sections
Diflucan HUMAN PRESCRIPTION DRUG LABEL 1 0049-3450 POWDER, FOR SUSPENSION 1400 mg ORAL NDA 27 sections
Diflucan HUMAN PRESCRIPTION DRUG LABEL 1 0049-3500 TABLET 150 mg ORAL NDA 27 sections
Diflucan HUMAN PRESCRIPTION DRUG LABEL 1 0049-3500 TABLET 150 mg ORAL NDA 27 sections
Fluconazole HUMAN PRESCRIPTION DRUG LABEL 1 0143-9666 INJECTION 2 mg INTRAVENOUS ANDA 21 sections
Fluconazole HUMAN PRESCRIPTION DRUG LABEL 1 0143-9667 INJECTION 2 mg INTRAVENOUS ANDA 21 sections
Fluconazole HUMAN PRESCRIPTION DRUG LABEL 1 0143-9668 INJECTION 2 mg INTRAVENOUS ANDA 21 sections
Fluconazole HUMAN PRESCRIPTION DRUG LABEL 1 0143-9669 INJECTION 2 mg INTRAVENOUS ANDA 21 sections
Fluconazole HUMAN PRESCRIPTION DRUG LABEL 1 0143-9899 INJECTION 2 mg INTRAVENOUS ANDA 21 sections
Fluconazole HUMAN PRESCRIPTION DRUG LABEL 1 0172-5410 TABLET 50 mg ORAL ANDA 13 sections
Fluconazole HUMAN PRESCRIPTION DRUG LABEL 1 0172-5410 TABLET 50 mg ORAL ANDA 13 sections
Fluconazole HUMAN PRESCRIPTION DRUG LABEL 1 0172-5411 TABLET 100 mg ORAL ANDA 13 sections
Fluconazole HUMAN PRESCRIPTION DRUG LABEL 1 0172-5411 TABLET 100 mg ORAL ANDA 13 sections
Fluconazole HUMAN PRESCRIPTION DRUG LABEL 1 0172-5412 TABLET 150 mg ORAL ANDA 13 sections
Fluconazole HUMAN PRESCRIPTION DRUG LABEL 1 0172-5412 TABLET 150 mg ORAL ANDA 13 sections
Fluconazole HUMAN PRESCRIPTION DRUG LABEL 1 0172-5413 TABLET 200 mg ORAL ANDA 13 sections
Fluconazole HUMAN PRESCRIPTION DRUG LABEL 1 0172-5413 TABLET 200 mg ORAL ANDA 13 sections
Fluconazole HUMAN PRESCRIPTION DRUG LABEL 1 0338-6045 INJECTION, SOLUTION 400 mg INTRAVENOUS ANDA 26 sections
Fluconazole HUMAN PRESCRIPTION DRUG LABEL 1 0338-6046 INJECTION, SOLUTION 200 mg INTRAVENOUS ANDA 26 sections
Fluconazole in Sodium Chloride HUMAN PRESCRIPTION DRUG LABEL 1 0409-4688 INJECTION, SOLUTION 2 mg INTRAVENOUS ANDA 25 sections
Fluconazole in Sodium Chloride HUMAN PRESCRIPTION DRUG LABEL 1 0409-4688 INJECTION, SOLUTION 2 mg INTRAVENOUS ANDA 25 sections
Fluconazole HUMAN PRESCRIPTION DRUG LABEL 1 0904-6500 TABLET 100 mg ORAL ANDA 25 sections