fendiline 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 1148 | 13042-18-7 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Coronary vasodilator; inhibits calcium function in muscle cells in excitation-contraction coupling; proposed as antiarrhythmic and antianginal agents.
|
Drug dosage:
None
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | C08EA01 | CARDIOVASCULAR SYSTEM CALCIUM CHANNEL BLOCKERS NON-SELECTIVE CALCIUM CHANNEL BLOCKERS Phenylalkylamine derivatives |
| MeSH PA | D002121 | Calcium Channel Blockers |
| MeSH PA | D000077264 | Calcium-Regulating Hormones and Agents |
| MeSH PA | D002317 | Cardiovascular Agents |
| MeSH PA | D049990 | Membrane Transport Modulators |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Ischemic heart disease | indication | 414545008 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 8.97 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 2B | GPCR | Ki | 5.49 | CHEMBL | |||||
| Extracellular calcium-sensing receptor | GPCR | EC50 | 6 | CHEMBL | |||||
| Sphingomyelin phosphodiesterase | Enzyme | IC50 | 5.25 | CHEMBL | |||||
| Transcriptional activator protein luxR | Unclassified | IC50 | 4.04 | CHEMBL | |||||
| Calmodulin | Cytosolic other | Kd | 6.30 | CHEMBL | |||||
| Extracellular calcium-sensing receptor | GPCR | POSITIVE ALLOSTERIC MODULATOR | EC50 | 4.92 | SCIENTIFIC LITERATURE |
External reference:
| ID | Source |
|---|---|
| N0000166521 | NUI |
| D07185 | KEGG_DRUG |
| 13636-18-5 | SECONDARY_CAS_RN |
| C0015824 | UMLSCUI |
| CHEBI:94434 | CHEBI |
| CHEMBL254832 | ChEMBL_ID |
| CHEMBL1405922 | ChEMBL_ID |
| DB08980 | DRUGBANK_ID |
| D005275 | MESH_DESCRIPTOR_UI |
| 3336 | PUBCHEM_CID |
| 2924 | INN_ID |
| S253D559A8 | UNII |
| 236767 | RXNORM |
| 006773 | NDDF |
| 006774 | NDDF |
Pharmaceutical products:
None