alexidine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	113	22573-93-9

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

alexidine
bisguadine
bisguanidine
alexidine dihydrochloride

until June 1975 was mistakenly treated as synonym for chlorhexidine; RN given refers to parent cpd

Molecular weight: 508.80
Formula: C26H56N10
CLOGP: 6.15
LIPINSKI: 3
HAC: 10
HDO: 10
TPSA: 167.58
ALOGS: -4.27
ROTB: 19

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
CHEBI has role	CHEBI:33282	bactericides

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	11.68	Basic
pKa2	11.08	Basic
pKa3	2.68	Basic
pKa4	2.08	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Toll-like receptor 9	Membrane receptor	Q9NR96	TLR9_HUMAN		IC50	5.21		CHEMBL
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1	Enzyme	Q8WUK0	PTPM1_HUMAN	INHIBITOR	IC50	7.97		SCIENTIFIC LITERATURE
Replicase polyprotein 1ab	Enzyme		R1AB_CVHSA		IC50	4.75		CHEMBL
Beta-lactamase	Enzyme		Q932Y6_PSEAI		IC50	5.28		CHEMBL

External reference:

ID	Source
D02804	KEGG_DRUG
C0051146	UMLSCUI
CHEBI:53661	CHEBI
CHEMBL1195210	ChEMBL_ID
C001570	MESH_SUPPLEMENTAL_RECORD_UI
2632	INN_ID
1715-30-6	SECONDARY_CAS_RN
GVN71CAL3G	UNII
2090	PUBCHEM_CID
CHEMBL1487183	ChEMBL_ID
CHEMBL554041	ChEMBL_ID

Pharmaceutical products:

None