exatecan 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antineoplastics, topoisomerase I inhibitors | 1120 | 171335-80-1 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
DX-8951a is hydrochloride & DX-895If is methanesulfonate; exatecan mesylate is a synonym for DX-8951f; structure given in first and second source
|
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| Vd (Volume of distribution) | 0.44 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 0.96 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 6.70 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D000970 | Antineoplastic Agents |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D059004 | Topoisomerase I Inhibitors |
| MeSH PA | D059003 | Topoisomerase Inhibitors |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 10.46 | acidic |
| pKa2 | 7.84 | Basic |
| pKa3 | 0.14 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| C0965941 | UMLSCUI |
| CHEBI:135709 | CHEBI |
| CHEMBL1614650 | ChEMBL_ID |
| DB12185 | DRUGBANK_ID |
| C095887 | MESH_SUPPLEMENTAL_RECORD_UI |
| 7887 | INN_ID |
| 197720-53-9 | SECONDARY_CAS_RN |
| OC71PP0F89 | UNII |
| 151115 | PUBCHEM_CID |
| CHEMBL3989759 | ChEMBL_ID |
Pharmaceutical products:
None