aldosterone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| corticosteroids, except prednisolone derivatives | 111 | 52-39-1 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A hormone secreted by the ADRENAL CORTEX that regulates electrolyte and water balance by increasing the renal retention of sodium and the excretion of potassium.
|
Drug dosage:
None
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | H02AA01 | SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS CORTICOSTEROIDS FOR SYSTEMIC USE CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN Mineralocorticoids |
| CHEBI has role | CHEBI:75771 | Mus musculus metabolites |
| CHEBI has role | CHEBI:77746 | Homo sapiens metabolite |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 12.58 | acidic |
| pKa2 | 13.29 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Mineralocorticoid receptor | Nuclear hormone receptor | EC50 | 8.42 | CHEMBL | |||||
| Corticosteroid-binding globulin | Secreted | Ki | 6.28 | CHEMBL | |||||
| Sex hormone-binding globulin | Secreted | Kd | 5.32 | CHEMBL | |||||
| Mineralocorticoid receptor | Transcription factor | IC50 | 7.37 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| N0000167497 | NUI |
| D10528 | KEGG_DRUG |
| 1312358 | RXNORM |
| C0002006 | UMLSCUI |
| CHEBI:27584 | CHEBI |
| AS4 | PDB_CHEM_ID |
| CHEMBL273453 | ChEMBL_ID |
| DB04630 | DRUGBANK_ID |
| D000450 | MESH_DESCRIPTOR_UI |
| 5839 | PUBCHEM_CID |
| 2872 | IUPHAR_LIGAND_ID |
| 483 | INN_ID |
| 4964P6T9RB | UNII |
| 22474002 | SNOMEDCT_US |
| 42605004 | SNOMEDCT_US |
| 002206 | NDDF |
Pharmaceutical products:
None