aldosterone Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
corticosteroids, except prednisolone derivatives 111 52-39-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • aldosterone
  • aldocorten
  • aldocortene
  • aldocortin
  • electrocortin
A hormone secreted by the ADRENAL CORTEX that regulates electrolyte and water balance by increasing the renal retention of sodium and the excretion of potassium.
  • Molecular weight: 360.45
  • Formula: C21H28O5
  • CLOGP: 1.76
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 2
  • TPSA: 91.67
  • ALOGS: -3.39
  • ROTB: 3

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC H02AA01 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
CORTICOSTEROIDS FOR SYSTEMIC USE
CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
Mineralocorticoids
CHEBI has role CHEBI:75771 mus musculus metabolite
CHEBI has role CHEBI:77746 h. sapiens metabolites

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.58 acidic
pKa2 13.29 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sex hormone-binding globulin Secreted Kd 5.32 CHEMBL
Mineralocorticoid receptor Nuclear hormone receptor EC50 8.42 CHEMBL
Corticosteroid-binding globulin Secreted Ki 6.28 CHEMBL
Mineralocorticoid receptor Transcription factor IC50 7.37 CHEMBL

External reference:

IDSource
4964P6T9RB UNII
N0000167497 NUI
D10528 KEGG_DRUG
C0002006 UMLSCUI
CHEBI:27584 CHEBI
AS4 PDB_CHEM_ID
CHEMBL273453 ChEMBL_ID
DB04630 DRUGBANK_ID
D000450 MESH_DESCRIPTOR_UI
5839 PUBCHEM_CID
483 INN_ID
2872 IUPHAR_LIGAND_ID
1312358 RXNORM
002206 NDDF
22474002 SNOMEDCT_US
42605004 SNOMEDCT_US

Pharmaceutical products:

None