ethylestrenol Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
anabolic steroids 1094 965-90-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • orabolin
  • ethylestrenol
  • estrenolethyl
  • ethylnandrol
An anabolic steroid with some progestational activity and little androgenic effect.
  • Molecular weight: 288.48
  • Formula: C20H32O
  • CLOGP: 6.09
  • LIPINSKI: 1
  • HAC: 1
  • HDO: 1
  • TPSA: 20.23
  • ALOGS: -5.53
  • ROTB: 1

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
2 mg O

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
May 28, 1964 FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC A14AB02 ALIMENTARY TRACT AND METABOLISM
ANABOLIC AGENTS FOR SYSTEMIC USE
ANABOLIC STEROIDS
Estren derivatives
MeSH PA D045930 Anabolic Agents
MeSH PA D006728 Hormones

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Androgen receptor Nuclear hormone receptor AGONIST CHEMBL CHEMBL
Sodium-dependent noradrenaline transporter Transporter Ki 5.68 DRUG MATRIX
Muscarinic acetylcholine receptor M2 GPCR Ki 6.98 DRUG MATRIX
Estrogen receptor Nuclear hormone receptor Ki 6.49 DRUG MATRIX
Sodium-dependent serotonin transporter Transporter Ki 7.37 DRUG MATRIX
Cytochrome P450 2C19 Enzyme IC50 5.89 DRUG MATRIX
Acetylcholinesterase Enzyme IC50 5.19 DRUG MATRIX
Androgen receptor Transcription factor Ki 7.74 DRUG MATRIX
Progesterone receptor Transcription factor Ki 7.59 DRUG MATRIX

External reference:

IDSource
4018517 VUID
N0000146839 NUI
D01414 KEGG_DRUG
4018517 VANDF
C0015099 UMLSCUI
CHEBI:31578 CHEBI
CHEMBL1200623 ChEMBL_ID
DB01493 DRUGBANK_ID
D005032 MESH_DESCRIPTOR_UI
13765 PUBCHEM_CID
6948 IUPHAR_LIGAND_ID
1107 INN_ID
ADC79EK5Q8 UNII
4162 RXNORM
001251 NDDF
126170002 SNOMEDCT_US
80618000 SNOMEDCT_US

Pharmaceutical products:

None