ethyl biscoumacetate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
anticoagulants, dicoumarol derivatives 1091 548-00-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • carbethoxydicoumarol
  • ethyldicoumarol
  • ethyl biscoumacetate
  • neodicoumarin
  • neodicoumarol
  • neodicumarinum
  • neodicumarol
  • trombarin
  • trombolysan
  • tromexan ethyl acetate
A coumarin that is used as an anticoagulant. It has actions similar to those of WARFARIN. (From Martindale, The Extra Pharmacopoeia, 30th ed, p226)
  • Molecular weight: 408.36
  • Formula: C22H16O8
  • CLOGP: 3.15
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 2
  • TPSA: 119.36
  • ALOGS: -3.78
  • ROTB: 5

Drug dosage:

DoseUnitRoute
0.60 g O

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 41.98 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC B01AA08 BLOOD AND BLOOD FORMING ORGANS
ANTITHROMBOTIC AGENTS
ANTITHROMBOTIC AGENTS
Vitamin K antagonists
MeSH PA D000925 Anticoagulants
MeSH PA D006401 Hematologic Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.31 acidic
pKa2 7.26 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Vitamin K epoxide reductase complex subunit 1 Enzyme WOMBAT-PK

External reference:

IDSource
D07131 KEGG_DRUG
C0015056 UMLSCUI
CHEBI:135659 CHEBI
CHEMBL2106261 ChEMBL_ID
CHEMBL81697 ChEMBL_ID
D005017 MESH_DESCRIPTOR_UI
DB08794 DRUGBANK_ID
54685524 PUBCHEM_CID
325 INN_ID
08KL644731 UNII
002083 NDDF
51739000 SNOMEDCT_US

Pharmaceutical products:

None