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enflurane 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| halogenated compounds used as general inhalation anaesthetics | 1009 | 13838-16-9 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
An extremely stable inhalation anesthetic that allows rapid adjustments of anesthesia depth with little change in pulse or respiratory rate.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,JAK3,MAP2K6,MAP3K7,MAPK7,MAPKAPK2,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PIK3CD,PIK3CG,PRKDC,STK33,SYK,TEK | 33 | |||
| kinase-selectivity-class | PDK1,PDK2 | 2 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 1 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Aug. 28, 1972 | FDA | BAXTER HLTHCARE |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | N01AB04 | NERVOUS SYSTEM ANESTHETICS ANESTHETICS, GENERAL Halogenated hydrocarbons |
| MeSH PA | D000777 | Anesthetics |
| MeSH PA | D002492 | Central Nervous System Depressants |
| MeSH PA | D018685 | Anesthetics, Inhalation |
| CHEBI has role | CHEBI:38867 | anaesthetic |
| FDA EPC | N0000175681 | General Anesthetic |
| FDA PE | N0000175975 | General Anesthesia |
Related Drugs by ATC class:
N01AB Halogenated hydrocarbons 6 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| General anesthesia | indication | 50697003 | |
| Hyperkalemia | contraindication | 14140009 | |
| Duchenne muscular dystrophy | contraindication | 76670001 | DOID:11723 |
| Seizure disorder | contraindication | 128613002 | |
| Malignant hyperthermia | contraindication | 405501007 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Glycine receptor subunit alpha-1 | Ion channel | POSITIVE MODULATOR | WOMBAT-PK | CHEMBL | |||||
| Potassium channel subfamily K member 2 | Ion channel | OPENER | CHEMBL | CHEMBL | |||||
| Potassium channel subfamily K member 3 | Ion channel | OPENER | CHEMBL | CHEMBL | |||||
| Potassium channel subfamily K member 9 | Ion channel | OPENER | CHEMBL | CHEMBL | |||||
| Potassium channel subfamily K member 10 | Ion channel | OPENER | CHEMBL | CHEMBL | |||||
| Potassium channel subfamily K member 18 | Ion channel | OPENER | CHEMBL | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4019106 | VUID |
| N0000147363 | NUI |
| D00543 | KEGG_DRUG |
| 4019106 | VANDF |
| C0014277 | UMLSCUI |
| CHEBI:4792 | CHEBI |
| CHEMBL1257 | ChEMBL_ID |
| DB00228 | DRUGBANK_ID |
| D004737 | MESH_DESCRIPTOR_UI |
| 3226 | PUBCHEM_CID |
| 3015 | INN_ID |
| 7175 | IUPHAR_LIGAND_ID |
| 91I69L5AY5 | UNII |
| 204234 | RXNORM |
| 1631 | MMSL |
| 3821 | MMSL |
| 7410 | MMSL |
| d00937 | MMSL |
| 001390 | NDDF |
| 32313007 | SNOMEDCT_US |
| 387176008 | SNOMEDCT_US |
Pharmaceutical products:
None