enflurane Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
halogenated compounds used as general inhalation anaesthetics 1009 13838-16-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • enflurane
  • (+/-)-Enflurane
  • efrane
  • ethrane
  • methylflurether
An extremely stable inhalation anesthetic that allows rapid adjustments of anesthesia depth with little change in pulse or respiratory rate.
  • Molecular weight: 184.49
  • Formula: C3H2ClF5O
  • CLOGP: 2.46
  • LIPINSKI: 0
  • HAC: 1
  • HDO: 0
  • TPSA: 9.23
  • ALOGS: -1.67
  • ROTB: 3

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Aug. 28, 1972 FDA BAXTER HLTHCARE

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC N01AB04 NERVOUS SYSTEM
ANESTHETICS
ANESTHETICS, GENERAL
Halogenated hydrocarbons
FDA EPC N0000175681 General Anesthetic
CHEBI has role CHEBI:38867 anaesthetic
MeSH PA D000777 Anesthetics
MeSH PA D018685 Anesthetics, Inhalation
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
FDA PE N0000175975 General Anesthesia

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
General anesthesia indication 50697003
Hyperkalemia contraindication 14140009
Duchenne muscular dystrophy contraindication 76670001 DOID:11723
Seizure disorder contraindication 128613002
Malignant hyperthermia contraindication 405501007

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Potassium channel subfamily K member 10 Ion channel OPENER CHEMBL CHEMBL
Potassium channel subfamily K member 18 Ion channel OPENER CHEMBL CHEMBL
Potassium channel subfamily K member 3 Ion channel OPENER CHEMBL CHEMBL
Potassium channel subfamily K member 9 Ion channel OPENER CHEMBL CHEMBL
Potassium channel subfamily K member 2 Ion channel OPENER CHEMBL CHEMBL
Glycine receptor subunit alpha-1 Ion channel POSITIVE MODULATOR WOMBAT-PK CHEMBL

External reference:

IDSource
4019106 VUID
N0000147363 NUI
D00543 KEGG_DRUG
4019106 VANDF
C4256131 UMLSCUI
CHEBI:4792 CHEBI
CHEMBL1257 ChEMBL_ID
DB00228 DRUGBANK_ID
D004737 MESH_DESCRIPTOR_UI
3226 PUBCHEM_CID
7175 IUPHAR_LIGAND_ID
3015 INN_ID
91I69L5AY5 UNII
204234 RXNORM
1631 MMSL
3821 MMSL
7410 MMSL
d00937 MMSL
001390 NDDF
32313007 SNOMEDCT_US
387176008 SNOMEDCT_US

Pharmaceutical products:

None