enflurane Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
halogenated compounds used as general inhalation anaesthetics 1009 13838-16-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • enflurane
  • (+/-)-Enflurane
  • efrane
  • ethrane
  • methylflurether
An extremely stable inhalation anesthetic that allows rapid adjustments of anesthesia depth with little change in pulse or respiratory rate.
  • Molecular weight: 184.49
  • Formula: C3H2ClF5O
  • CLOGP: 2.46
  • LIPINSKI: 0
  • HAC: 1
  • HDO: 0
  • TPSA: 9.23
  • ALOGS: -1.67
  • ROTB: 3

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Aug. 28, 1972 FDA BAXTER HLTHCARE

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC N01AB04 NERVOUS SYSTEM
ANESTHETICS
ANESTHETICS, GENERAL
Halogenated hydrocarbons
FDA PE N0000175975 General Anesthesia
FDA EPC N0000175681 General Anesthetic
MeSH PA D000777 Anesthetics
MeSH PA D018685 Anesthetics, Inhalation
CHEBI has role CHEBI:38867 anaesthetic
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
General anesthesia indication 50697003
Hyperkalemia contraindication 14140009
Duchenne muscular dystrophy contraindication 76670001 DOID:11723
Seizure disorder contraindication 128613002
Malignant hyperthermia contraindication 405501007

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Potassium channel subfamily K member 10 Ion channel OPENER CHEMBL CHEMBL
Potassium channel subfamily K member 18 Ion channel OPENER CHEMBL CHEMBL
Potassium channel subfamily K member 3 Ion channel OPENER CHEMBL CHEMBL
Potassium channel subfamily K member 9 Ion channel OPENER CHEMBL CHEMBL
Potassium channel subfamily K member 2 Ion channel OPENER CHEMBL CHEMBL
Glycine receptor subunit alpha-1 Ion channel POSITIVE MODULATOR WOMBAT-PK CHEMBL

External reference:

IDSource
D004737 MESH_DESCRIPTOR_UI
4019106 VUID
N0000147363 NUI
C0014277 UMLSCUI
D00543 KEGG_DRUG
32313007 SNOMEDCT_US
3821 MMSL
3920 RXNORM
387176008 SNOMEDCT_US
7410 MMSL
d00937 MMSL
4019106 VANDF
001390 NDDF
91I69L5AY5 UNII
3015 INN_ID
3226 PUBCHEM_CID
CHEBI:4792 CHEBI
CHEMBL1257 ChEMBL_ID
DB00228 DRUGBANK_ID
7175 IUPHAR_LIGAND_ID

Pharmaceutical products:

None