butenafine indications/contra

Stem definitionDrug idCAS RN
444 101828-21-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • KP-363
  • KP 363
  • butenafine
  • butenafine hydrochloride
  • butenafine HCl
studied on experimental dermatophytosis
  • Molecular weight: 317.48
  • Formula: C23H27N
  • CLOGP: 6.74
  • LIPINSKI: 1
  • HAC: 1
  • HDO: 0
  • TPSA: 3.24
  • ALOGS: -6.62
  • ROTB: 5

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
Oct. 18, 1996 FDA MYLAN

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC D01AE23 DERMATOLOGICALS
ANTIFUNGALS FOR DERMATOLOGICAL USE
ANTIFUNGALS FOR TOPICAL USE
Other antifungals for topical use
FDA EPC N0000175875 Benzylamine Antifungal
FDA Chemical/Ingredient N0000007566 Benzylamines
CHEBI has role CHEBI:86327 antifungal drug
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000935 Antifungal Agents

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Tinea pedis indication 6020002 DOID:12403
Pityriasis versicolor indication 56454009 DOID:9060
Tinea corporis indication 84849002 DOID:12179
Tinea cruris indication 399029005

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.59 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 5.78 DRUG MATRIX
Sodium-dependent serotonin transporter Transporter Ki 6.12 DRUG MATRIX
Sodium-dependent noradrenaline transporter Transporter Ki 5.41 DRUG MATRIX
Cytochrome P450 2D6 Enzyme IC50 6.52 DRUG MATRIX
Acetylcholinesterase Enzyme IC50 5.16 DRUG MATRIX
Alpha-2A adrenergic receptor GPCR Ki 5.86 DRUG MATRIX
Squalene epoxidase Enzyme INHIBITOR CHEMBL CHEMBL
Membrane-associated progesterone receptor component 1 Membrane receptor Ki 6.80 DRUG MATRIX
Enoyl-[acyl-carrier-protein] reductase [NADH] Enzyme IC50 4.12 CHEMBL
Squalene monooxygenase Enzyme IC50 7.35 WOMBAT-PK

External reference:

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IDSource
4024054 VUID
N0000022059 NUI
C0107497 UMLSCUI
D01093 KEGG_DRUG
DB01091 DRUGBANK_ID
CHEMBL990 ChEMBL_ID
4024054 VANDF
N0000022059 NDFRT
N0000006118 NDFRT
4313 MMSL
47461 RXNORM
108923003 SNOMEDCT_US
373449007 SNOMEDCT_US
006293 NDDF
91Y494NL0X UNII
6550 INN_ID
2484 PUBCHEM_CID
CHEMBL1200397 ChEMBL_ID
C067594 MESH_SUPPLEMENTAL_RECORD_UI
101827-46-7 SECONDARY_CAS_RN
CHEBI:3238 CHEBI

Pharmaceutical products:

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ProductCategoryIngredientsNDCFormQuantityRoute MarketingLabel
Athletes Foot HUMAN OTC DRUG LABEL 1 0363-2100 CREAM 10 mg TOPICAL ANDA 10 sections
Jock Itch HUMAN OTC DRUG LABEL 1 0363-2101 CREAM 10 mg TOPICAL ANDA 10 sections
MENTAX HUMAN PRESCRIPTION DRUG LABEL 1 0378-6151 CREAM 10 mg TOPICAL NDA 12 sections
Lotrimin Ultra HUMAN OTC DRUG LABEL 1 11523-4338 CREAM 1 g TOPICAL NDA 9 sections
Lotrimin Ultra HUMAN OTC DRUG LABEL 1 11523-4339 CREAM 1 g TOPICAL NDA 9 sections
Lotrimin Ultra HUMAN OTC DRUG LABEL 1 11523-7154 CREAM 10 mg TOPICAL NDA 10 sections
Lotrimin Ultra Jock Itch HUMAN OTC DRUG LABEL 1 11523-7155 CREAM 10 mg TOPICAL NDA 10 sections
Athletes Foot HUMAN OTC DRUG LABEL 1 11673-016 CREAM 10 mg TOPICAL ANDA 10 sections
Athletes Foot HUMAN OTC DRUG LABEL 1 11822-2100 CREAM 10 mg TOPICAL ANDA 10 sections
Athletes Foot HUMAN OTC DRUG LABEL 1 36800-049 CREAM 10 mg TOPICAL ANDA 10 sections
Athletes Foot HUMAN OTC DRUG LABEL 1 51672-2100 CREAM 10 mg TOPICAL ANDA 10 sections
Jock Itch HUMAN OTC DRUG LABEL 1 51672-2101 CREAM 10 mg TOPICAL ANDA 10 sections
Lotrimin Ultra HUMAN OTC DRUG LABEL 1 69213-4339 CREAM 1 g TOPICAL NDA 9 sections
Athletes Foot HUMAN OTC DRUG LABEL 1 69842-986 CREAM 10 mg TOPICAL ANDA 10 sections