naftifine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1872 65472-88-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • naftifine
  • naftifine hydrochloride
  • naftifungin
  • naftifine HCl
  • naftifin
allylamine der; RN given refers to unlabeled parent cpd
  • Molecular weight: 287.41
  • Formula: C21H21N
  • CLOGP: 5.52
  • LIPINSKI: 1
  • HAC: 1
  • HDO: 0
  • TPSA: 3.24
  • ALOGS: -6.10
  • ROTB: 5

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Feb. 29, 1988 FDA MERZ PHARMS

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D01AE22 DERMATOLOGICALS
ANTIFUNGALS FOR DERMATOLOGICAL USE
ANTIFUNGALS FOR TOPICAL USE
Other antifungals for topical use
FDA CS M0000751 Allylamine
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000935 Antifungal Agents
CHEBI has role CHEBI:59285 squalene monooxygenase inhibitors
CHEBI has role CHEBI:83317 sterol biosynthesis inhibitors
FDA EPC N0000175874 Allylamine Antifungal

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Tinea pedis indication 6020002 DOID:12403
Tinea corporis indication 84849002
Tinea cruris indication 399029005
Pityriasis versicolor off-label use 56454009 DOID:9060




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.87 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
2% NAFTIN SEBELA IRELAND LTD N204286 June 27, 2013 RX GEL TOPICAL 9161914 Jan. 31, 2033 TREATMENT OF FUNGAL INFECTIONS

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase Enzyme Ki 5.82 CHEMBL
Squalene monooxygenase Enzyme WOMBAT-PK
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 6.06 CHEMBL
Squalene epoxidase Enzyme INHIBITOR CHEMBL CHEMBL
C-8 sterol isomerase Enzyme Ki 6.51 CHEMBL
Squalene monooxygenase Enzyme IC50 6.50 CHEMBL
Dehydrosqualene desaturase Enzyme IC50 6.53 CHEMBL

External reference:

IDSource
4019850 VUID
N0000171577 NUI
D00883 KEGG_DRUG
65473-14-5 SECONDARY_CAS_RN
4019526 VANDF
4019850 VANDF
C0068367 UMLSCUI
CHEBI:7451 CHEBI
CHEMBL626 ChEMBL_ID
DB00735 DRUGBANK_ID
CHEMBL1200493 ChEMBL_ID
C029178 MESH_SUPPLEMENTAL_RECORD_UI
47641 PUBCHEM_CID
4588 INN_ID
4FB1TON47A UNII
31476 RXNORM
234377 MMSL
5146 MMSL
002929 NDDF
002930 NDDF
13800009 SNOMEDCT_US
372655002 SNOMEDCT_US
47408003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
NAFTIFINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0115-1510 GEL 10 mg TOPICAL ANDA 17 sections
NAFTIFINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0115-1512 CREAM 20 mg TOPICAL ANDA 23 sections
Naftin HUMAN PRESCRIPTION DRUG LABEL 1 0259-4126 CREAM 10 mg TOPICAL NDA 19 sections
Naftifine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 51672-1362 CREAM 10 mg TOPICAL ANDA 19 sections
Naftifine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 51672-1368 CREAM 20 mg TOPICAL ANDA 25 sections
Naftifine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 51672-1376 GEL 20 mg TOPICAL ANDA 25 sections
Naftifine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 51672-1376 GEL 20 mg TOPICAL ANDA 25 sections
Naftin HUMAN PRESCRIPTION DRUG LABEL 1 54766-770 GEL 10 mg TOPICAL NDA 19 sections
Naftin HUMAN PRESCRIPTION DRUG LABEL 1 54766-772 GEL 2 g TOPICAL NDA 26 sections
Naftin HUMAN PRESCRIPTION DRUG LABEL 1 54868-2185 GEL 10 mg TOPICAL NDA 19 sections
Naftin HUMAN PRESCRIPTION DRUG LABEL 1 54868-2240 CREAM 10 mg TOPICAL NDA 19 sections
Naftifine hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 70700-161 CREAM 20 mg TOPICAL ANDA 24 sections