bupranolol indications/contra

Stem definitionDrug idCAS RN
beta-adrenoreceptor antagonists 433 14556-46-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • bupranolol
  • (+/-)-Bupranolol
  • bupranol
  • bupranolol hydrochloride
  • bupranolol HCl
An adrenergic-beta-2 antagonist that has been used for cardiac arrhythmia, angina pectoris, hypertension, glaucoma, and as an antithrombotic.
  • Molecular weight: 271.79
  • Formula: C14H22ClNO2
  • CLOGP: 3.10
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 2
  • TPSA: 41.49
  • ALOGS: -3.28
  • ROTB: 6

Drug dosage:

None

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC C07AA19 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS
Beta blocking agents, non-selective
MeSH PA D018663 Adrenergic Agents
MeSH PA D018674 Adrenergic Antagonists
MeSH PA D000319 Adrenergic beta-Antagonists
MeSH PA D000889 Anti-Arrhythmia Agents
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D018377 Neurotransmitter Agents

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Glaucoma indication 23986001 DOID:1686
Hypertensive disorder indication 38341003 DOID:10763

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.31 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Beta-2 adrenergic receptor GPCR ANTAGONIST Ki 9.10 IUPHAR IUPHAR
Beta-1 adrenergic receptor GPCR ANTAGONIST Ki 9 IUPHAR IUPHAR
Beta-3 adrenergic receptor GPCR ANTAGONIST Ki 7.30 IUPHAR

External reference:

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IDSource
550 IUPHAR_LIGAND_ID
N0000166825 NUI
C0006403 UMLSCUI
D01454 KEGG_DRUG
CHEMBL305380 ChEMBL_ID
2475 PUBCHEM_CID
N0000166825 NDFRT
1817 RXNORM
006894 NDDF
858YGI5PIT UNII
3166 INN_ID
CHEBI:135123 CHEBI
D002046 MESH_DESCRIPTOR_UI
15148-80-8 SECONDARY_CAS_RN
DB08808 DRUGBANK_ID

Pharmaceutical products:

None